psnGPCR

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Orange: nodes, hubs and links specific of muscarinic_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of muscarinic_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	muscarinic_off Int. Strength	muscarinic_on Int. Strength	muscarinic_off Hub1?	muscarinic_on Hub1?	muscarinic_off Hub2?	muscarinic_on Hub2?	ConSurf1	ConSurf2
1	1x50	2x47	muscarinic_off	100	0	No	No	No	No	9	9
2	1x53	7x53	muscarinic_off	100	0	No	No	Yes	Yes	9	9
3	1x55	8x57	muscarinic_off	100	0	No	No	No	No	6	7
4	2x40	I1x50	muscarinic_off	100	0	Yes	Yes	Yes	No	9	9
5	8x53	I1x50	muscarinic_off	100	0	No	No	Yes	No	8	9
6	2x42	3x46	muscarinic_off	100	0	Yes	Yes	No	No	8	9
7	2x43	7x53	muscarinic_off	100	0	No	No	Yes	Yes	8	9
8	2x45	4x50	muscarinic_off	100	0	No	No	No	No	9	9
9	2x46	3x39	muscarinic_off	100	0	No	No	No	No	9	9
10	2x46	3x42	muscarinic_off	100	0	No	No	No	No	9	9
11	2x52	3x31	muscarinic_off	100	0	No	No	No	No	8	6
12	2x53	7x42	muscarinic_off	100	0	No	Yes	Yes	Yes	8	9
13	2x60	7x35	muscarinic_off	100	0	Yes	Yes	No	No	8	6
14	3x28	3x32	muscarinic_off	100	0	Yes	Yes	Yes	No	7	9
15	3x29	E2x50	muscarinic_off	100	0	No	No	No	No	7	9
16	3x36	6x48	muscarinic_off	100	0	No	No	Yes	Yes	8	9
17	3x39	7x45	muscarinic_off	100	0	No	No	Yes	No	9	9
18	3x43	6x44	muscarinic_off	100	0	No	No	Yes	Yes	9	9
19	3x44	5x50	muscarinic_off	100	0	No	No	No	No	7	9
20	3x44	5x54	muscarinic_off	100	0	No	No	No	No	7	9
21	3x48	3x52	muscarinic_off	100	0	No	No	Yes	No	7	6
22	3x50	5x61	muscarinic_off	100	0	Yes	No	No	No	9	9
23	3x50	6x30	muscarinic_off	100	0	Yes	No	Yes	No	9	9
24	3x50	6x33	muscarinic_off	100	0	Yes	No	No	No	9	8
25	3x52	3x56	muscarinic_off	100	0	Yes	No	Yes	No	6	7
26	3x53	I2x57	muscarinic_off	100	0	No	No	Yes	Yes	8	8
27	4x57	E2	muscarinic_off	100	0	Yes	Yes	Yes	Yes	8	5
28	4x68	E2	muscarinic_off	100	0	No	No	Yes	Yes	4	5
29	5x43	E2	muscarinic_off	100	0	No	No	Yes	Yes	9	5
30	5x41	5x45	muscarinic_off	100	0	No	No	No	No	7	7
31	5x43	Lig	muscarinic_off	100	0	No	No	Yes	Yes	9	0
32	5x48	6x52	muscarinic_off	100	0	No	Yes	No	No	8	7
33	5x54	6x41	muscarinic_off	100	0	No	No	No	No	9	8
34	5x58	5x62	muscarinic_off	100	0	No	Yes	No	No	9	8
35	5x58	6x38	muscarinic_off	100	0	No	Yes	No	No	9	7
36	5x62	5x63	muscarinic_off	100	0	No	No	No	No	8	5
37	6x37	6x41	muscarinic_off	100	0	No	No	No	No	9	8
38	6x40	7x49	muscarinic_off	100	0	No	Yes	No	No	9	9
39	6x44	7x45	muscarinic_off	100	0	Yes	Yes	Yes	No	9	9
40	6x51	7x34	muscarinic_off	100	0	No	Yes	Yes	No	8	6
41	6x52	Lig	muscarinic_off	100	0	No	No	Yes	Yes	7	0
42	6x54	7x34	muscarinic_off	100	0	No	No	Yes	No	7	6
43	8x50	8x54	muscarinic_off	100	0	Yes	Yes	Yes	No	9	9
44	3x32	7x38	muscarinic_off	100	0	Yes	No	Yes	Yes	9	7
45	4x64	4x67	muscarinic_off	100	0	No	No	No	No	6	5
46	5x40	6x55	muscarinic_off	100	0	No	No	No	No	8	8
47	2x39	3x50	muscarinic_off	100	0	No	No	Yes	No	9	9
48	5x36	5x37	muscarinic_off	100	0	No	No	No	No	7	4
49	5x64	5x67	muscarinic_off	100	0	No	No	No	No	7	6
50	5x51	6x45	muscarinic_off	60	0	No	No	No	No	7	7
51	8x51	8x55	muscarinic_off	46.6667	0	No	No	No	No	9	7
52	5x59	5x60	muscarinic_off	26.6667	0	No	No	No	No	4	6
53	8x59	CT	muscarinic_off	26.6667	0	No	No	Yes	Yes	4	0
54	3x50	6x34	muscarinic_off	60	0	Yes	No	No	No	9	8
55	3x41	4x49	muscarinic_off	26.6667	0	No	No	No	No	8	8
56	1x47	2x51	muscarinic_off	60	0	No	No	No	No	7	8
57	1x31	NT	muscarinic_off	40	0	No	Yes	No	No	5	4
58	3x54	5x61	muscarinic_off	46.6667	0	No	No	No	No	8	9
59	1x52	8x58	muscarinic_off	33.3333	0	No	No	No	No	8	8
60	1x54	2x51	muscarinic_off	60	0	No	No	No	No	7	8
61	6x39	7x52	muscarinic_off	40	0	No	No	No	No	8	9
62	5x53	5x57	muscarinic_off	0	0	No	No	Yes	No	7	8
63	7x54	8x54	muscarinic_off	20	0	No	No	Yes	No	8	9
64	6x29	6x30	muscarinic_off	26.6667	0	No	No	Yes	No	7	9
65	6x32	8x47	muscarinic_off	26.6667	0	No	No	No	No	9	9
66	1x56	8x57	muscarinic_off	40	0	No	No	No	No	9	7
67	5x42	5x45	muscarinic_off	26.6667	0	No	No	No	No	6	7
68	4x52	4x56	muscarinic_off	6.66667	0	No	No	No	No	6	8
69	5x68	6x30	muscarinic_off	20	0	No	No	Yes	No	8	9
70	4x63	4x66	muscarinic_off	13.3333	0	No	No	No	No	7	6
71	5x68	6x31	muscarinic_off	20	0	No	No	No	No	8	7
72	3x21	E1x50	muscarinic_off	0	0	No	No	Yes	Yes	7	9
73	5x69	6x24	muscarinic_off	20	0	No	No	No	No	5	0
74	1x27	NT	muscarinic_off	20	0	No	No	No	No	0	4
75	E1x49	E2	muscarinic_off	0	0	No	No	Yes	Yes	4	5
76	6x49	6x53	muscarinic_off	0	0	No	No	No	No	7	7
77	5x44	Lig	muscarinic_off	0	0	No	No	Yes	Yes	8	0
78	7x43	7x48	muscarinic_off	0	0	No	No	No	No	6	6
79	6x26	6x30	muscarinic_off	20	0	No	No	Yes	No	5	9
80	1x39	1x40	muscarinic_off	20	0	Yes	No	No	No	7	4
81	6x27	6x30	muscarinic_off	20	0	No	No	Yes	No	4	9
82	5x51	5x55	muscarinic_off	0	0	No	No	No	No	7	6
83	4x38	4x39	muscarinic_off	20	0	No	No	No	No	9	5
84	1x41	1x45	muscarinic_off	20	0	No	No	No	No	5	5
85	1x35	1x39	muscarinic_off	0	0	No	No	Yes	No	6	7
86	4x69	E2	muscarinic_off	20	0	No	No	Yes	Yes	5	5
87	7x32	7x36	muscarinic_off	0	0	No	No	No	No	4	5
88	4x44	4x48	muscarinic_off	20	0	No	No	No	No	4	4
89	6x36	7x53	muscarinic_off	20	0	No	No	Yes	Yes	9	9
90	I2x53	I2x54	muscarinic_off	20	0	Yes	Yes	No	No	9	7
91	1x31	1x35	muscarinic_off	6.66667	0	No	Yes	No	No	5	6
92	1x58	2x44	muscarinic_off	20	0	No	No	No	No	5	7
93	5x69	6x27	muscarinic_off	20	0	No	No	No	No	5	4
94	5x65	5x68	muscarinic_off	20	0	No	No	No	No	8	8
95	6x32	8x48	muscarinic_off	20	0	No	No	No	No	9	5
96	6x25	6x27	muscarinic_off	20	0	No	No	No	No	5	4
97	7x55	7x56	muscarinic_off	0	0	No	No	No	No	7	9
98	1x30	1x34	muscarinic_off	0	0	No	No	No	No	3	3
99	1x29	1x33	muscarinic_off	20	0	No	No	No	No	5	6
100	1x29	NT	muscarinic_off	20	0	No	No	No	No	5	4
101	8x59	8x61	muscarinic_off	0	0	No	No	No	No	4	0
102	2x67	E1x49	muscarinic_off	0	0	No	No	No	No	6	4
103	8x60	CT	muscarinic_off	0	0	No	No	Yes	Yes	0	0
104	1x28	1x31	Shared	100	25	No	No	No	Yes	5	5
105	1x32	2x65	Shared	100	6.25	No	No	No	Yes	4	6
106	1x34	1x38	Shared	100	43.75	No	No	No	No	3	4
107	1x39	2x61	Shared	100	100	Yes	No	No	No	7	7
108	1x39	7x39	Shared	100	100	Yes	No	Yes	Yes	7	9
109	1x43	2x58	Shared	100	100	No	No	No	No	8	9
110	1x46	2x57	Shared	100	100	No	No	Yes	Yes	8	9
111	1x46	7x47	Shared	100	100	No	No	No	No	8	7
112	1x50	2x50	Shared	100	100	No	No	Yes	Yes	9	9
113	1x50	7x50	Shared	100	100	No	No	No	No	9	9
114	1x52	8x54	Shared	100	100	No	No	Yes	No	8	9
115	1x54	2x44	Shared	100	100	No	No	No	No	7	7
116	1x56	8x53	Shared	100	100	No	No	No	No	9	8
117	1x56	8x54	Shared	100	56.25	No	No	Yes	No	9	9
118	1x57	2x44	Shared	100	100	Yes	Yes	No	No	8	7
119	1x60	I1x49	Shared	100	100	Yes	Yes	No	No	8	6
120	1x60	I1x50	Shared	100	100	Yes	Yes	Yes	No	8	9
121	1x60	8x53	Shared	100	100	Yes	Yes	No	No	8	8
122	I1x48	I1x51	Shared	100	100	No	No	No	No	8	8
123	8x49	I1x50	Shared	100	100	No	No	Yes	No	7	9
124	8x50	I1x50	Shared	100	100	Yes	Yes	Yes	No	9	9
125	2x37	2x40	Shared	100	100	No	No	Yes	Yes	8	9
126	2x38	I2x57	Shared	100	100	No	No	Yes	Yes	7	8
127	2x39	I2x57	Shared	100	100	No	No	Yes	Yes	9	8
128	2x40	8x50	Shared	100	100	Yes	Yes	Yes	Yes	9	9
129	2x41	4x39	Shared	100	0	No	No	No	No	8	5
130	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	8
131	2x42	3x49	Shared	100	100	Yes	Yes	No	Yes	8	9
132	2x42	4x46	Shared	100	100	Yes	Yes	Yes	Yes	8	9
133	2x45	3x42	Shared	100	100	No	No	No	No	9	9
134	2x45	4x46	Shared	100	100	No	No	Yes	Yes	9	9
135	2x50	3x39	Shared	100	31.25	Yes	Yes	No	No	9	9
136	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	9
137	2x50	7x49	Shared	100	100	Yes	Yes	No	No	9	9
138	2x53	2x56	Shared	100	100	No	Yes	No	No	8	8
139	2x53	7x46	Shared	100	100	No	Yes	No	No	8	9
140	2x54	2x57	Shared	100	50	No	No	Yes	Yes	8	9
141	2x55	2x551	Shared	100	62.5	No	No	No	No	5	5
142	2x551	3x31	Shared	100	43.75	No	No	No	No	5	6
143	2x56	3x32	Shared	100	100	No	No	Yes	No	8	9
144	2x56	7x42	Shared	100	100	No	No	Yes	Yes	8	9
145	2x57	7x39	Shared	100	100	Yes	Yes	Yes	Yes	9	9
146	2x57	7x42	Shared	100	100	Yes	Yes	Yes	Yes	9	9
147	2x59	3x28	Shared	100	100	No	No	Yes	Yes	7	7
148	2x60	2x64	Shared	100	100	Yes	Yes	No	No	8	7
149	2x60	3x28	Shared	100	100	Yes	Yes	Yes	Yes	8	7
150	2x60	7x38	Shared	100	100	Yes	Yes	Yes	Yes	8	7
151	2x60	7x39	Shared	100	100	Yes	Yes	Yes	Yes	8	9
152	2x60	7x42	Shared	100	100	Yes	Yes	Yes	Yes	8	9
153	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	7	9
154	2x66	E1x49	Shared	100	50	No	Yes	No	No	6	4
155	2x66	E1x51	Shared	100	25	No	Yes	No	No	6	4
156	E1x50	E1x52	Shared	100	100	Yes	Yes	No	No	9	8
157	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	9
158	3x28	E1x50	Shared	100	100	Yes	Yes	Yes	Yes	7	9
159	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	9	9
160	3x24	E1x52	Shared	100	100	No	No	No	No	6	8
161	3x22	E2	Shared	100	100	No	No	Yes	Yes	4	5
162	3x23	3x27	Shared	100	0	No	No	No	No	4	6
163	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
164	3x26	4x65	Shared	100	100	No	No	No	No	7	7
165	3x26	E2	Shared	100	100	No	No	Yes	Yes	7	5
166	3x29	E2x52	Shared	100	100	No	No	Yes	Yes	7	7
167	3x32	7x42	Shared	100	100	Yes	No	Yes	Yes	9	9
168	3x32	Lig	Shared	100	100	Yes	No	Yes	Yes	9	0
169	3x33	4x57	Shared	100	100	Yes	Yes	Yes	Yes	8	8
170	3x33	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
171	3x33	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
172	3x36	Lig	Shared	100	100	No	No	Yes	Yes	8	0
173	3x37	4x53	Shared	100	100	No	Yes	No	No	9	9
174	3x37	4x57	Shared	100	100	No	Yes	Yes	Yes	9	8
175	3x38	4x50	Shared	100	100	No	No	No	No	8	9
176	3x47	5x54	Shared	100	31.25	No	No	No	No	9	9
177	3x48	5x57	Shared	100	100	No	No	Yes	No	7	8
178	3x49	I2x53	Shared	100	100	No	Yes	Yes	Yes	9	9
179	3x49	I2x57	Shared	100	100	No	Yes	Yes	Yes	9	8
180	3x51	3x52	Shared	100	100	Yes	Yes	Yes	No	9	6
181	3x51	3x55	Shared	100	100	Yes	Yes	No	No	9	8
182	3x51	5x57	Shared	100	100	Yes	Yes	Yes	No	9	8
183	3x51	5x60	Shared	100	100	Yes	Yes	No	No	9	6
184	3x52	I2x53	Shared	100	100	Yes	No	Yes	Yes	6	9
185	3x53	I2x53	Shared	100	75	No	No	Yes	Yes	8	9
186	3x55	3x56	Shared	100	31.25	No	No	Yes	No	8	7
187	I2x53	I2x57	Shared	100	100	Yes	Yes	Yes	Yes	9	8
188	4x38	4x41	Shared	100	25	No	No	No	No	9	8
189	4x54	4x58	Shared	100	100	No	No	No	No	5	6
190	4x57	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
191	4x60	E2	Shared	100	18.75	No	No	Yes	Yes	7	5
192	4x61	E2x52	Shared	100	100	No	No	Yes	Yes	8	7
193	4x62	4x63	Shared	100	50	No	Yes	No	No	6	7
194	4x64	4x68	Shared	100	100	No	No	No	No	6	4
195	4x64	E2	Shared	100	100	No	No	Yes	Yes	6	5
196	4x65	4x66	Shared	100	100	No	No	No	No	7	6
197	4x65	E2	Shared	100	100	No	No	Yes	Yes	7	5
198	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	5	5
199	E2	E2x51	Shared	100	100	Yes	Yes	No	No	5	4
200	E2	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	5	7
201	5x40	E2	Shared	100	100	No	No	Yes	Yes	8	5
202	5x36	5x38	Shared	100	31.25	No	No	No	No	7	4
203	5x36	5x39	Shared	100	100	No	No	No	No	7	8
204	5x41	6x56	Shared	100	100	No	No	No	No	7	7
205	5x461	Lig	Shared	100	37.5	No	No	Yes	Yes	8	0
206	5x47	5x48	Shared	100	100	Yes	Yes	No	Yes	9	8
207	5x47	5x51	Shared	100	100	Yes	Yes	No	No	9	7
208	5x47	6x44	Shared	100	100	Yes	Yes	Yes	Yes	9	9
209	5x47	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	9
210	5x47	6x52	Shared	100	100	Yes	Yes	No	No	9	7
211	5x49	5x50	Shared	100	25	No	No	No	No	7	9
212	5x59	5x63	Shared	100	100	No	No	No	No	4	5
213	6x40	7x53	Shared	100	100	No	Yes	Yes	Yes	9	9
214	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	9
215	6x47	6x48	Shared	100	100	No	No	Yes	Yes	9	9
216	6x47	7x45	Shared	100	100	No	No	Yes	No	9	9
217	6x48	7x41	Shared	100	100	Yes	Yes	No	No	9	8
218	6x48	7x45	Shared	100	100	Yes	Yes	Yes	No	9	9
219	6x48	Lig	Shared	100	100	Yes	Yes	Yes	Yes	9	0
220	6x50	7x40	Shared	100	31.25	No	No	No	No	9	8
221	6x51	7x38	Shared	100	100	No	Yes	Yes	Yes	8	7
222	6x51	Lig	Shared	100	100	No	Yes	Yes	Yes	8	0
223	6x54	E3	Shared	100	25	No	No	Yes	Yes	7	5
224	6x57	E3	Shared	100	100	No	No	Yes	Yes	7	5
225	6x58	7x34	Shared	100	100	No	No	Yes	No	4	6
226	6x59	6x60	Shared	100	100	No	Yes	No	No	7	7
227	6x61	E3	Shared	100	100	No	No	Yes	Yes	7	5
228	7x34	E3	Shared	100	100	Yes	No	Yes	Yes	6	5
229	7x30	7x33	Shared	100	100	No	No	No	No	7	5
230	7x38	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
231	7x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	9	9
232	7x41	Lig	Shared	100	100	No	No	Yes	Yes	8	0
233	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	9	0
234	7x45	7x49	Shared	100	100	Yes	No	No	No	9	9
235	8x47	8x49	Shared	100	100	No	No	No	No	9	7
236	8x47	8x50	Shared	100	100	No	No	Yes	Yes	9	9
237	2x64	7x35	Shared	100	100	No	No	No	No	7	6
238	3x28	3x29	Shared	100	100	Yes	Yes	No	No	7	7
239	3x33	7x38	Shared	100	100	Yes	Yes	Yes	Yes	8	7
240	5x41	6x59	Shared	100	100	No	No	No	Yes	7	7
241	7x31	7x35	Shared	100	25	No	No	No	No	4	6
242	7x38	7x42	Shared	100	100	Yes	Yes	Yes	Yes	7	9
243	1x57	I1x51	Shared	100	50	Yes	Yes	No	No	8	8
244	1x57	2x41	Shared	100	56.25	Yes	Yes	No	No	8	8
245	8x48	8x51	Shared	100	25	No	No	No	No	5	9
246	2x63	E2	Shared	100	100	No	No	Yes	Yes	7	5
247	1x59	CT	Shared	100	25	No	No	Yes	Yes	7	0
248	8x48	8x52	Shared	100	25	No	No	No	No	5	6
249	1x51	2x51	Shared	60	37.5	No	No	No	No	6	8
250	3x40	5x50	Shared	66.6667	31.25	No	No	No	No	9	9
251	3x56	I2x52	Shared	53.3333	100	Yes	No	No	No	7	6
252	1x43	2x57	Shared	40	18.75	No	No	Yes	Yes	8	9
253	1x35	2x65	Shared	40	6.25	No	No	No	Yes	6	6
254	1x49	7x50	Shared	60	25	No	No	No	No	9	9
255	3x37	3x41	Shared	40	100	No	Yes	No	No	9	8
256	7x30	E3	Shared	60	31.25	No	No	Yes	Yes	7	5
257	3x41	4x52	Shared	40	0	No	No	No	No	8	6
258	1x42	7x39	Shared	60	100	No	No	Yes	Yes	6	9
259	1x57	2x40	Shared	40	25	Yes	Yes	Yes	Yes	8	9
260	3x45	4x45	Shared	20	31.25	No	No	No	No	8	8
261	2x42	4x42	Shared	40	12.5	Yes	Yes	No	No	8	8
262	8x56	CT	Shared	40	25	No	No	Yes	Yes	6	0
263	6x49	6x50	Shared	40	31.25	No	No	No	No	7	9
264	2x52	3x35	Shared	40	100	No	No	No	No	8	7
265	3x34	4x54	Shared	26.6667	25	No	No	No	No	8	5
266	5x56	5x60	Shared	60	6.25	No	No	No	No	5	6
267	2x40	2x43	Shared	46.6667	43.75	Yes	Yes	No	No	9	8
268	4x38	4x40	Shared	20	100	No	No	No	No	9	5
269	5x39	E2	Shared	26.6667	100	No	No	Yes	Yes	8	5
270	6x36	7x56	Shared	40	6.25	No	No	No	No	9	9
271	3x47	5x57	Shared	6.66667	100	No	No	Yes	No	9	8
272	1x47	2x55	Shared	40	0	No	No	No	No	7	5
273	6x43	7x48	Shared	46.6667	0	No	No	No	No	8	6
274	6x42	6x46	Shared	26.6667	6.25	No	No	No	No	7	5
275	1x45	7x47	Shared	6.66667	0	No	No	No	No	5	7
276	3x30	4x62	Shared	46.6667	18.75	No	No	No	Yes	8	6
277	2x49	4x50	Shared	0	0	No	No	No	No	9	9
278	5x45	5x48	Shared	40	100	No	No	No	Yes	7	8
279	1x54	2x48	Shared	6.66667	0	No	No	No	No	7	7
280	2x62	2x66	Shared	40	6.25	No	No	No	Yes	5	6
281	6x45	6x49	Shared	0	100	No	No	No	No	7	7
282	7x39	7x43	Shared	26.6667	31.25	Yes	Yes	No	No	9	6
283	6x40	7x52	Shared	26.6667	31.25	No	Yes	No	No	9	9
284	3x54	5x64	Shared	0	25	No	No	No	No	8	7
285	1x60	CT	Shared	20	25	Yes	Yes	Yes	Yes	8	0
286	6x54	7x37	Shared	6.66667	0	No	No	No	No	7	6
287	6x38	6x42	Shared	20	0	No	No	No	No	7	7
288	4x51	4x55	Shared	6.66667	0	No	No	No	No	5	5
289	4x58	4x59	Shared	13.3333	6.25	No	No	No	No	6	8
290	5x62	5x66	Shared	20	100	No	No	No	Yes	8	7
291	4x41	I2x56	Shared	33.3333	18.75	No	No	No	No	8	6
292	4x46	4x47	Shared	53.3333	0	Yes	Yes	No	No	9	4
293	1x44	1x48	Shared	20	0	No	No	No	No	6	5
294	7x51	7x55	Shared	6.66667	25	No	No	No	No	7	7
295	6x32	6x35	Shared	33.3333	18.75	No	No	No	No	9	8
296	1x48	1x52	Shared	0	0	No	No	No	No	5	8
297	3x56	I2x50	Shared	0	0	Yes	No	No	No	7	9
298	1x36	2x65	Shared	0	0	No	No	No	Yes	5	6
299	3x34	4x53	Shared	0	25	No	No	No	No	8	9
300	4x43	4x46	Shared	33.3333	25	No	No	Yes	Yes	4	9
301	1x38	1x42	Shared	0	0	No	No	No	No	4	6
302	1x33	1x37	Shared	6.66667	0	No	No	No	No	6	4
303	7x36	7x37	Shared	0	0	No	No	No	No	5	6
304	3x27	4x62	Shared	0	6.25	No	No	No	Yes	6	6
305	4x54	4x55	Shared	0	0	No	No	No	No	5	5
306	4x48	4x52	Shared	20	25	No	No	No	No	4	6
307	5x52	5x56	Shared	0	0	No	No	No	No	5	5
308	6x28	6x31	Shared	6.66667	6.25	No	No	No	No	5	7
309	I2x51	I2x52	Shared	0	6.25	No	No	No	No	7	6
310	I2x55	I2x56	Shared	0	0	No	No	No	No	5	6
311	1x29	1x30	muscarinic_on	0	100	No	No	No	No	5	3
312	1x30	1x31	muscarinic_on	0	100	No	No	No	Yes	3	5
313	2x39	3x49	muscarinic_on	0	100	No	No	No	Yes	9	9
314	2x46	2x50	muscarinic_on	0	100	No	No	Yes	Yes	9	9
315	2x46	3x43	muscarinic_on	0	100	No	No	No	No	9	9
316	2x46	7x49	muscarinic_on	0	100	No	No	No	No	9	9
317	2x53	3x35	muscarinic_on	0	100	No	Yes	No	No	8	7
318	2x53	3x36	muscarinic_on	0	100	No	Yes	No	No	8	8
319	3x33	6x51	muscarinic_on	0	100	Yes	Yes	No	Yes	8	8
320	3x40	6x48	muscarinic_on	0	100	No	No	Yes	Yes	9	9
321	3x42	4x50	muscarinic_on	0	100	No	No	No	No	9	9
322	3x43	7x53	muscarinic_on	0	100	No	No	Yes	Yes	9	9
323	3x44	3x48	muscarinic_on	0	100	No	No	No	No	7	7
324	3x44	5x53	muscarinic_on	0	100	No	No	No	No	7	7
325	3x46	3x50	muscarinic_on	0	100	No	No	Yes	No	9	9
326	3x46	7x53	muscarinic_on	0	100	No	No	Yes	Yes	9	9
327	3x47	5x58	muscarinic_on	0	100	No	No	No	Yes	9	9
328	3x50	5x58	muscarinic_on	0	100	Yes	No	No	Yes	9	9
329	3x50	7x53	muscarinic_on	0	100	Yes	No	Yes	Yes	9	9
330	4x56	4x57	muscarinic_on	0	100	No	No	Yes	Yes	8	8
331	4x57	5x43	muscarinic_on	0	100	Yes	Yes	No	No	8	9
332	4x64	5x36	muscarinic_on	0	100	No	No	No	No	6	7
333	5x40	6x59	muscarinic_on	0	100	No	No	No	Yes	8	7
334	5x48	6x56	muscarinic_on	0	100	No	Yes	No	No	8	7
335	5x51	6x44	muscarinic_on	0	100	No	No	Yes	Yes	7	9
336	5x55	6x41	muscarinic_on	0	100	No	No	No	No	6	8
337	5x58	6x37	muscarinic_on	0	100	No	Yes	No	No	9	9
338	5x58	6x40	muscarinic_on	0	100	No	Yes	No	Yes	9	9
339	5x58	6x41	muscarinic_on	0	100	No	Yes	No	No	9	8
340	5x62	6x34	muscarinic_on	0	100	No	No	No	No	8	8
341	5x65	6x33	muscarinic_on	0	100	No	No	No	No	8	8
342	5x66	6x30	muscarinic_on	0	100	No	Yes	Yes	No	7	9
343	6x51	6x52	muscarinic_on	0	100	No	Yes	No	No	8	7
344	6x51	6x55	muscarinic_on	0	100	No	Yes	No	No	8	8
345	6x58	E3	muscarinic_on	0	100	No	No	Yes	Yes	4	5
346	E3	E3	muscarinic_on	0	100	Yes	Yes	Yes	Yes	5	5
347	7x34	7x38	muscarinic_on	0	100	Yes	No	Yes	Yes	6	7
348	7x55	8x54	muscarinic_on	0	100	No	No	Yes	No	7	9
349	8x52	8x55	muscarinic_on	0	100	No	No	No	No	6	7
350	3x37	Lig	muscarinic_on	0	100	No	Yes	Yes	Yes	9	0
351	3x40	6x44	muscarinic_on	0	100	No	No	Yes	Yes	9	9
352	6x30	6x31	muscarinic_on	0	100	Yes	No	No	No	9	7
353	CT	CT	muscarinic_on	0	100	Yes	Yes	Yes	Yes	0	0
354	I2x52	I2x56	muscarinic_on	0	56.25	No	No	No	No	6	6
355	1x50	2x51	muscarinic_on	0	37.5	No	No	No	No	9	8
356	5x47	6x49	muscarinic_on	0	62.5	Yes	Yes	No	No	9	7
357	5x37	6x59	muscarinic_on	0	50	No	No	No	Yes	4	7
358	1x53	2x47	muscarinic_on	0	0	No	No	No	No	9	9
359	7x54	8x50	muscarinic_on	0	50	No	No	Yes	Yes	8	9
360	3x53	I2x54	muscarinic_on	0	25	No	No	No	No	8	7
361	1x37	1x41	muscarinic_on	0	25	No	No	No	No	4	5
362	3x51	5x61	muscarinic_on	0	37.5	Yes	Yes	No	No	9	9
363	2x38	4x39	muscarinic_on	0	50	No	No	No	No	7	5
364	3x26	4x62	muscarinic_on	0	31.25	No	No	No	Yes	7	6
365	2x61	2x65	muscarinic_on	0	25	No	No	No	Yes	7	6
366	E1x50	E1x51	muscarinic_on	0	50	Yes	Yes	No	No	9	4
367	1x40	1x43	muscarinic_on	0	31.25	No	No	No	No	4	8
368	3x55	5x64	muscarinic_on	0	25	No	No	No	No	8	7
369	1x54	2x47	muscarinic_on	0	0	No	No	No	No	7	9
370	7x48	7x52	muscarinic_on	0	31.25	No	No	No	No	6	9
371	1x57	1x58	muscarinic_on	0	25	Yes	Yes	No	No	8	5
372	4x40	4x44	muscarinic_on	0	31.25	No	No	No	No	5	4
373	5x68	5x72	muscarinic_on	0	37.5	No	No	No	No	8	0
374	2x52	2x551	muscarinic_on	0	37.5	No	No	No	No	8	5
375	3x45	4x49	muscarinic_on	0	0	No	No	No	No	8	8
376	6x36	6x40	muscarinic_on	0	0	No	No	No	Yes	9	9
377	5x62	6x37	muscarinic_on	0	25	No	No	No	No	8	9
378	5x65	5x66	muscarinic_on	0	25	No	No	No	Yes	8	7
379	8x58	CT	muscarinic_on	0	25	No	No	Yes	Yes	8	0
380	4x67	4x68	muscarinic_on	0	25	No	No	No	No	5	4
381	5x48	6x53	muscarinic_on	0	0	No	Yes	No	No	8	7
382	6x34	6x38	muscarinic_on	0	6.25	No	No	No	No	8	7
383	5x44	5x48	muscarinic_on	0	0	No	No	No	Yes	8	8
384	3x21	3x24	muscarinic_on	0	0	No	No	No	No	7	6
385	1x55	1x59	muscarinic_on	0	6.25	No	No	No	No	6	7
386	5x41	5x42	muscarinic_on	0	0	No	No	No	No	7	6
387	5x67	5x69	muscarinic_on	0	0	No	No	No	No	6	5
388	6x35	6x36	muscarinic_on	0	25	No	No	No	No	8	9
389	8x55	8x58	muscarinic_on	0	18.75	No	No	No	No	7	8
390	5x68	5x69	muscarinic_on	0	0	No	No	No	No	8	5
391	8x55	8x59	muscarinic_on	0	25	No	No	No	No	7	4
392	1x52	8x57	muscarinic_on	0	25	No	No	No	No	8	7
393	4x68	4x69	muscarinic_on	0	0	No	No	No	No	4	5
394	7x32	7x35	muscarinic_on	0	0	No	No	No	No	4	6
395	5x66	5x68	muscarinic_on	0	12.5	No	Yes	No	No	7	8
396	5x67	6x29	muscarinic_on	0	6.25	No	No	No	No	6	7
397	2x66	2x67	muscarinic_on	0	0	No	Yes	No	No	6	6
398	6x27	6x31	muscarinic_on	0	0	No	No	No	No	4	7
399	5x67	5x71	muscarinic_on	0	0	No	No	No	No	6	0
400	4x56	5x46	muscarinic_on	0	0	No	No	No	No	8	6
401	6x25	6x26	muscarinic_on	0	0	No	No	No	No	5	5
402	6x26	6x27	muscarinic_on	0	0	No	No	No	No	5	4
403	1x34	1x37	muscarinic_on	0	0	No	No	No	No	3	4
404	5x63	5x66	muscarinic_on	0	6.25	No	No	No	Yes	5	7
405	8x56	8x60	muscarinic_on	0	0	No	No	No	No	6	0
406	5x69	5x70	muscarinic_on	0	0	No	No	No	No	5	0
407	1x31	1x32	muscarinic_on	0	0	No	Yes	No	No	5	4
408	1x26	1x31	muscarinic_on	0	6.25	No	No	No	Yes	0	5
409	6x35	6x39	muscarinic_on	0	0	No	No	No	No	8	8
410	1x27	1x31	muscarinic_on	0	0	No	No	No	Yes	0	5

Orange: nodes, hubs and links specific of muscarinic_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of muscarinic_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	muscarinic_off Avg Int. Strength	muscarinic_on Avg Int. Strength	muscarinic_off Num Of Links	muscarinic_on Num Of Links	ConSurf
1	1x39	muscarinic_off	0	0	4	2	7
2	I1x50	muscarinic_off	80	37.5	5	3	9
3	3x32	muscarinic_off	93.3333	12.5	5	3	9
4	3x50	muscarinic_off	40	0	5	3	9
5	3x52	muscarinic_off	40	0	4	2	6
6	3x56	muscarinic_off	0	0	4	3	7
7	5x57	muscarinic_off	0	0	4	3	8
8	6x30	muscarinic_off	0	0	5	2	9
9	7x34	muscarinic_off	100	0	4	3	6
10	7x45	muscarinic_off	80	25	5	3	9
11	8x54	muscarinic_off	20	12.5	4	3	9
12	1x57	Shared	13.3333	12.5	4	5	8
13	1x60	Shared	20	25	4	4	8
14	2x40	Shared	40	37.5	5	4	9
15	2x42	Shared	93.3333	50	5	4	8
16	2x50	Shared	86.6667	62.5	4	5	9
17	2x57	Shared	53.3333	12.5	5	5	9
18	2x60	Shared	80	68.75	6	5	8
19	E1x50	Shared	100	87.5	6	6	9
20	3x28	Shared	93.3333	75	5	4	7
21	3x33	Shared	93.3333	68.75	4	5	8
22	3x51	Shared	80	62.5	4	5	9
23	I2x53	Shared	53.3333	75	5	4	9
24	I2x57	Shared	100	100	5	4	8
25	4x46	Shared	20	0	4	4	9
26	4x57	Shared	73.3333	100	4	5	8
27	E2	Shared	100	100	17	12	5
28	E2x52	Shared	100	12.5	4	4	7
29	5x47	Shared	100	100	5	6	9
30	6x44	Shared	86.6667	75	4	4	9
31	6x48	Shared	100	100	7	7	9
32	E3	Shared	100	68.75	5	8	5
33	7x38	Shared	80	68.75	6	6	7
34	7x39	Shared	60	75	6	6	9
35	7x42	Shared	100	100	8	7	9
36	7x53	Shared	33.3333	87.5	4	4	9
37	8x50	Shared	100	50	4	4	9
38	Lig	Shared	100	100	13	11	0
39	CT	Shared	20	25	5	6	0
40	1x31	muscarinic_on	0	0	3	5	5
41	2x53	muscarinic_on	26.6667	0	3	4	8
42	2x65	muscarinic_on	0	0	3	4	6
43	2x66	muscarinic_on	0	0	3	4	6
44	3x37	muscarinic_on	40	56.25	3	4	9
45	3x49	muscarinic_on	40	50	3	4	9
46	4x62	muscarinic_on	0	0	3	4	6
47	5x48	muscarinic_on	0	37.5	3	5	8
48	5x58	muscarinic_on	0	68.75	2	5	9
49	5x66	muscarinic_on	0	0	1	5	7
50	6x40	muscarinic_on	0	0	3	4	9
51	6x51	muscarinic_on	40	75	3	5	8
52	6x59	muscarinic_on	0	12.5	2	4	7

Orange: nodes, hubs and links specific of muscarinic_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of muscarinic_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	muscarinic_off Recurrence	muscarinic_on Recurrence	muscarinic_off Hub1?	muscarinic_on Hub1?	muscarinic_off Hub2?	muscarinic_on Hub2?	ConSurf1	ConSurf2
1	1x31	1x35	muscarinic_off	11.7496	0	No	Yes	No	No	5	6
2	1x35	1x39	muscarinic_off	18.3958	0	No	No	Yes	No	6	7
3	2x53	7x42	muscarinic_off	22.2242	0	No	Yes	Yes	Yes	8	9
4	2x50	7x49	muscarinic_off	31.0489	1.22648	Yes	Yes	No	No	9	9
5	6x40	7x49	muscarinic_off	87.7326	0	No	Yes	No	No	9	9
6	2x43	7x53	muscarinic_off	77.4615	0	No	No	Yes	Yes	8	9
7	2x40	2x43	muscarinic_off	76.2437	1.09696	Yes	Yes	No	No	9	8
8	8x50	8x54	muscarinic_off	13.8067	0	Yes	Yes	Yes	No	9	9
9	1x57	2x44	muscarinic_off	18.9315	5.4534	Yes	Yes	No	No	8	7
10	1x54	2x44	muscarinic_off	15.853	4.37018	No	No	No	No	7	7
11	2x40	I1x50	muscarinic_off	19.8243	0	Yes	Yes	Yes	No	9	9
12	2x50	3x39	muscarinic_off	33.3524	0.904649	Yes	Yes	No	No	9	9
13	2x46	3x39	muscarinic_off	100	0	No	No	No	No	9	9
14	2x46	3x42	muscarinic_off	99	0	No	No	No	No	9	9
15	2x45	3x42	muscarinic_off	97.9929	4.37018	No	No	No	No	9	9
16	2x45	4x46	muscarinic_off	93.8931	5.4534	No	No	Yes	Yes	9	9
17	2x42	4x46	muscarinic_off	90.7432	8.67953	Yes	Yes	Yes	Yes	8	9
18	3x49	I2x57	muscarinic_off	26.9883	1.20489	No	Yes	Yes	Yes	9	8
19	3x39	7x45	muscarinic_off	72.4367	0	No	No	Yes	No	9	9
20	2x39	I2x57	muscarinic_off	25.9955	0.902686	No	No	Yes	Yes	9	8
21	1x54	2x51	muscarinic_off	12.7388	0	No	No	No	No	7	8
22	4x57	Lig	muscarinic_off	37.4308	2.6904	Yes	Yes	Yes	Yes	8	0
23	4x57	E2	muscarinic_off	26.3812	0	Yes	Yes	Yes	Yes	8	5
24	E1x49	E2	muscarinic_off	10.0211	0	No	No	Yes	Yes	4	5
25	5x43	Lig	muscarinic_off	24.5706	0	No	No	Yes	Yes	9	0
26	5x43	E2	muscarinic_off	23.8491	0	No	No	Yes	Yes	9	5
27	4x65	E2	muscarinic_off	13.6495	1.825	No	No	Yes	Yes	7	5
28	4x65	4x66	muscarinic_off	11.9389	1.0165	No	No	No	No	7	6
29	3x37	4x57	muscarinic_off	15.2959	0.731961	No	Yes	Yes	Yes	9	8
30	3x48	3x52	muscarinic_off	15.878	0	No	No	Yes	No	7	6
31	3x48	5x57	muscarinic_off	14.4709	3.28892	No	No	Yes	No	7	8
32	3x47	5x54	muscarinic_off	20.6707	1.09892	No	No	No	No	9	9
33	3x44	5x54	muscarinic_off	11.8531	0	No	No	No	No	7	9
34	2x39	3x50	muscarinic_off	24.5348	0	No	No	Yes	No	9	9
35	3x50	6x30	muscarinic_off	14.9923	0	Yes	No	Yes	No	9	9
36	3x51	5x60	muscarinic_off	16.5351	3.28892	Yes	Yes	No	No	9	6
37	5x45	5x48	muscarinic_off	10.3032	0.896799	No	No	No	Yes	7	8
38	5x47	5x51	muscarinic_off	15.7209	0.904649	Yes	Yes	No	No	9	7
39	5x59	5x60	muscarinic_off	12.1103	0	No	No	No	No	4	6
40	5x59	5x63	muscarinic_off	10.621	1.09892	No	No	No	No	4	5
41	5x51	6x45	muscarinic_off	11.2639	0	No	No	No	No	7	7
42	6x51	Lig	muscarinic_off	13.4495	1.38935	No	Yes	Yes	Yes	8	0
43	6x51	7x34	muscarinic_off	15.928	0	No	Yes	Yes	No	8	6
44	8x47	8x50	muscarinic_off	10.8568	2.1429	No	No	Yes	Yes	9	9
45	6x44	7x45	muscarinic_off	10.2318	0	Yes	Yes	Yes	No	9	9
46	1x39	7x39	Shared	23.1992	16.4014	Yes	No	Yes	Yes	7	9
47	7x39	7x42	Shared	33.4167	23.2677	Yes	Yes	Yes	Yes	9	9
48	2x53	7x46	Shared	22.8849	28.6407	No	Yes	No	No	8	9
49	2x50	7x46	Shared	22.8456	28.8801	Yes	Yes	No	No	9	9
50	6x40	7x53	Shared	84.1898	51.5591	No	Yes	Yes	Yes	9	9
51	2x40	8x50	Shared	25.1812	28.2933	Yes	Yes	Yes	Yes	9	9
52	7x42	Lig	Shared	34.9452	27.1885	Yes	Yes	Yes	Yes	9	0
53	6x48	Lig	Shared	82.3649	62.7053	Yes	Yes	Yes	Yes	9	0
54	6x48	7x45	Shared	86.854	69.8365	Yes	Yes	Yes	No	9	9
55	7x45	7x49	Shared	62.6335	70.5351	Yes	No	No	No	9	9
56	1x57	2x40	Shared	33.5095	31.2486	Yes	Yes	Yes	Yes	8	9
57	1x60	I1x50	Shared	11.3746	22.4435	Yes	Yes	Yes	No	8	9
58	2x42	3x49	Shared	85.2612	13.9406	Yes	Yes	No	Yes	8	9
59	1x57	2x41	Shared	10.7318	39.9027	Yes	Yes	No	No	8	8
60	3x49	I2x53	Shared	57.4301	14.5745	No	Yes	Yes	Yes	9	9
61	3x52	I2x53	Shared	56.8515	60.1798	Yes	No	Yes	Yes	6	9
62	3x47	5x57	Shared	23.5956	78.6809	No	No	Yes	No	9	8
63	3x51	3x52	Shared	33.131	61.0334	Yes	Yes	Yes	No	9	6
64	3x51	5x57	Shared	15.0423	75.5882	Yes	Yes	Yes	No	9	8
65	5x47	6x48	Shared	13.5031	11.2934	Yes	Yes	Yes	Yes	9	9
66	2x57	7x42	Shared	13.3388	10.0453	Yes	Yes	Yes	Yes	9	9
67	2x61	2x65	muscarinic_on	0	13.7581	No	No	No	Yes	7	6
68	1x39	2x61	muscarinic_on	1.78565	15.2122	Yes	No	No	No	7	7
69	2x56	7x42	muscarinic_on	0.60355	23.8623	No	No	Yes	Yes	8	9
70	2x53	2x56	muscarinic_on	0.846398	24.5668	No	Yes	No	No	8	8
71	2x46	2x50	muscarinic_on	0	30.3989	No	No	Yes	Yes	9	9
72	2x46	3x43	muscarinic_on	0	99.9804	No	No	No	No	9	9
73	3x43	7x53	muscarinic_on	0	100	No	No	Yes	Yes	9	9
74	3x50	7x53	muscarinic_on	0	48.0288	Yes	No	Yes	Yes	9	9
75	3x50	5x58	muscarinic_on	0	48.0955	Yes	No	No	Yes	9	9
76	3x47	5x58	muscarinic_on	0	80.2037	No	No	No	Yes	9	9
77	I2x53	I2x57	muscarinic_on	3.14632	43.0189	Yes	Yes	Yes	Yes	9	8
78	2x38	I2x57	muscarinic_on	1.54994	42.5479	No	No	Yes	Yes	7	8
79	2x38	4x39	muscarinic_on	0	41.7826	No	No	No	No	7	5
80	2x41	4x39	muscarinic_on	9.15682	40.8446	No	No	No	No	8	5
81	8x50	I1x50	muscarinic_on	0.474983	24.4157	Yes	Yes	Yes	No	9	9
82	2x46	7x49	muscarinic_on	0	69.5245	No	No	No	No	9	9
83	5x58	6x40	muscarinic_on	0	49.6693	No	Yes	No	Yes	9	9
84	2x60	3x28	muscarinic_on	3.17489	24.9593	Yes	Yes	Yes	Yes	8	7
85	2x60	7x38	muscarinic_on	6.20335	12.5905	Yes	Yes	Yes	Yes	8	7
86	3x28	E1x50	muscarinic_on	7.08903	20.6519	Yes	Yes	Yes	Yes	7	9
87	E2	E2x52	muscarinic_on	1.53209	20.5852	Yes	Yes	Yes	Yes	5	7
88	3x33	E2x52	muscarinic_on	4.06771	21.1798	Yes	Yes	Yes	Yes	8	7
89	3x33	Lig	muscarinic_on	3.65701	16.8253	Yes	Yes	Yes	Yes	8	0
90	3x51	3x55	muscarinic_on	1.82136	13.817	Yes	Yes	No	No	9	8
91	3x55	3x56	muscarinic_on	1.75351	10.6615	No	No	Yes	No	8	7
92	5x58	6x37	muscarinic_on	0	23.5248	No	Yes	No	No	9	9
93	5x62	6x37	muscarinic_on	0	22.5142	No	No	No	No	8	9
94	5x62	5x66	muscarinic_on	1.53566	17.4022	No	No	No	Yes	8	7
95	1x60	CT	muscarinic_on	8.42827	11.1913	Yes	Yes	Yes	Yes	8	0
96	2x60	7x42	muscarinic_on	6.0605	18.9721	Yes	Yes	Yes	Yes	8	9
97	7x38	Lig	muscarinic_on	4.3177	16.2425	Yes	Yes	Yes	Yes	7	0

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x53	2x56	Shared	6.604	4.4525	1	0	2	2
2x53	7x42	muscarinic_off	5.23933	0	1	0	2	1
2x56	3x32	Shared	10.7013	10.0325	1	1	2	1
2x56	7x42	Shared	7.03733	5.24813	1	1	2	1
2x57	7x39	Shared	5.97	7.48687	1	1	2	2
2x57	7x42	Shared	6.386	6.88125	1	1	2	1
2x60	3x28	Shared	6.48267	4.62375	1	1	2	2
2x60	7x38	Shared	18.532	12.7031	1	1	2	1
2x60	7x39	Shared	3.69667	3.765	1	1	2	2
2x60	7x42	Shared	6.46933	4.37625	1	1	2	1
3x28	3x32	muscarinic_off	8.188	0	0	0	2	1
3x32	7x42	Shared	9.5	10.0575	1	1	1	1
3x32	Lig	Shared	4.62467	7.51	1	1	1	0
3x33	4x57	Shared	14.018	14.9419	1	1	1	1
3x33	E2x52	Shared	9.26667	7.51062	1	1	1	2
3x33	Lig	Shared	19.9613	10.3237	1	1	1	0
3x36	6x48	muscarinic_off	4.77733	0	1	0	1	1
3x36	Lig	Shared	8.93133	8.43188	1	0	1	0
3x37	4x53	Shared	8.308	6.19438	0	1	1	2
3x37	4x57	Shared	9.21	8.6875	0	1	1	1
4x57	E2	muscarinic_off	4.43333	0	1	1	1	2
4x57	Lig	Shared	5.61933	9.99375	1	1	1	0
E2	E2	Shared	52.488	32.1738	1	1	2	2
E2	E2x52	Shared	16.3533	12.6237	1	1	2	2
5x43	E2	muscarinic_off	4.86067	0	1	0	1	2
5x43	Lig	muscarinic_off	3.98	0	1	0	1	0
5x461	Lig	Shared	4.47733	2.57812	0	0	1	0
5x47	5x48	Shared	7.42667	9.35	1	1	2	2
5x47	6x44	Shared	4.57467	4.02	1	1	2	2
5x47	6x48	Shared	5.546	5.5125	1	1	2	1
5x47	6x52	Shared	25.214	18.6519	1	1	2	1
5x48	6x52	muscarinic_off	4.186	0	1	0	2	1
6x44	6x48	Shared	18.106	7.8925	1	1	2	1
6x44	7x45	muscarinic_off	4.66933	0	1	1	2	2
6x47	6x48	Shared	4.608	4.6225	1	1	2	1
6x47	7x45	Shared	7.99333	8.6825	1	1	2	2
6x48	7x41	Shared	13.146	9.22437	1	1	1	1
6x48	7x45	Shared	7.006	9.8875	1	1	1	2
6x48	Lig	Shared	12.672	11.2625	1	1	1	0
6x51	7x34	muscarinic_off	6.62267	0	1	1	1	2
6x51	7x38	Shared	7.678	4.46875	1	1	1	1
6x51	Lig	Shared	14.524	10.6175	1	1	1	0
6x52	Lig	muscarinic_off	10.4173	0	1	0	1	0
7x38	Lig	Shared	15.8667	9.70437	1	1	1	0
7x39	7x42	Shared	5.07933	8.80125	1	1	2	1
7x41	Lig	Shared	6.13067	5.67688	1	1	1	0
7x42	Lig	Shared	4.47733	4.84438	1	1	1	0
3x32	7x38	muscarinic_off	4.67667	0	1	1	1	1
3x33	7x38	Shared	4.10267	5.08875	1	1	1	1
7x38	7x42	Shared	7.61333	5.27375	1	1	1	1
3x37	3x41	Shared	3.356	5.74062	0	1	1	2
5x44	Lig	muscarinic_off	2.13733	0	0	0	1	0
2x53	3x36	muscarinic_on	0	3.57812	1	0	2	1
3x33	6x51	muscarinic_on	0	5.33437	1	1	1	1
3x40	6x48	muscarinic_on	0	5.055	0	1	2	1
4x56	4x57	muscarinic_on	0	5.33812	0	0	2	1
4x57	5x43	muscarinic_on	0	7.3525	1	1	1	1
6x51	6x52	muscarinic_on	0	5.95938	1	1	1	1
6x51	6x55	muscarinic_on	0	5.75875	1	1	1	2
7x34	7x38	muscarinic_on	0	4.15937	1	1	2	1
3x37	Lig	muscarinic_on	0	4.76437	0	1	1	0
3x40	6x44	muscarinic_on	0	4.42438	0	1	2	2
5x44	5x48	muscarinic_on	0	1.33312	0	0	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	muscarinic_off	m2_off m3_off m4_off m5_off m1_off
	muscarinic_on	m2_on m3_on m4_on m1_on

Network Difference
Value	muscarinic_off	muscarinic_on
I_min	3.59133	3.57188
Number of Linked Nodes	271	273
Number of Specific Nodes	3 (1.11%)	5 (1.83%)
Number of Shared Nodes	268 (98.89%)	268 (98.17%)
Number of Links	310	307
Number of Specific Links	103 (33.23%)	100 (32.57%)
Number of Shared Links	207 (66.77%)	207 (67.43%)
Number of Hubs	39	41
Number of Specific Hubs	11 (28.21%)	13 (31.71%)
Number of Shared Hubs	28 (71.79%)	28 (68.29%)
Average % Shared Neighbours (Jaccard)	54.73
Average % Shared Neighbours (Otsuka)	62.76
Average % Shared Neighbours (Overlap Coefficient)	70.66
Average % Shared Cliques (k3-6)	60.42
Graphlets Similarity	0.725053

Paths Difference
Value	muscarinic_off	muscarinic_on
Number Of Nodes in MetaPath	64	50
Specific Nodes in MetaPath	33 (51.56%)	19 (38.00%)
Shared Nodes in MetaPath	268 (98.89%)	268 (98.89%)
Number Of Links MetaPath	66	52
Specific Links in MetaPath	45 (68.18%)	31 (59.62%)
Shared Links in MetaPath	207 (66.77%)	207 (66.77%)
Number of Shortest Paths	64249	75378
Length Of Smallest Path	3	3
Average Path Length	14.2415	17.6795
Length of Longest Path	34	38
Minimum Path Strength	0.834	0.21375
Average Path Strength	6.38463	6.31527
Maximum Path Strength	19.307	14.6159
Minimum Path Correlation	0.700667	0.7
Average Path Correlation	0.908729	0.9215
Maximum Path Correlation	0.988	0.98875
Minimum % Of Corr. Nodes	4.16667	3.0303
Average % Of Corr. Nodes	42.0574	37.8142
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	45.3838	45.9298
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download muscarinic_off_on.zip<

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