psnGPCR

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Orange: nodes, hubs and links specific of nk1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of nk1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	nk1_off Int. Strength	nk1_on Int. Strength	nk1_off Hub1?	nk1_on Hub1?	nk1_off Hub2?	nk1_on Hub2?	ConSurf1	ConSurf2
1	1x39	7x38	nk1_off	100	0	No	No	No	Yes	7	5
2	1x50	2x47	nk1_off	100	0	Yes	No	No	No	9	9
3	1x53	7x53	nk1_off	100	0	No	No	Yes	No	8	9
4	1x54	2x44	nk1_off	100	0	No	No	No	No	7	6
5	1x57	8x50	nk1_off	100	0	No	No	Yes	Yes	7	9
6	2x41	I1x51	nk1_off	100	0	Yes	No	Yes	No	5	6
7	2x38	3x49	nk1_off	100	0	No	No	No	No	6	9
8	2x38	4x42	nk1_off	100	0	No	No	No	No	6	7
9	2x39	3x46	nk1_off	100	0	No	No	No	No	8	9
10	2x39	3x49	nk1_off	100	0	No	No	No	No	8	9
11	2x39	3x50	nk1_off	100	0	No	No	No	No	8	9
12	2x50	3x39	nk1_off	100	0	Yes	Yes	No	No	9	9
13	2x56	3x27	nk1_off	100	0	No	No	Yes	No	5	4
14	2x57	3x31	nk1_off	100	0	Yes	Yes	No	No	6	4
15	2x67	E1x51	nk1_off	100	0	Yes	No	Yes	No	5	2
16	3x28	E1x50	nk1_off	100	0	Yes	Yes	Yes	Yes	5	8
17	E1x51	E1x52	nk1_off	100	0	Yes	No	Yes	Yes	2	7
18	3x28	3x29	nk1_off	100	0	Yes	Yes	Yes	No	5	5
19	3x29	4x61	nk1_off	100	0	Yes	No	Yes	Yes	5	6
20	3x30	4x57	nk1_off	100	0	No	No	No	No	6	7
21	3x30	4x62	nk1_off	100	0	No	No	No	No	6	5
22	3x32	Lig	nk1_off	100	0	No	No	Yes	Yes	6	0
23	3x33	5x43	nk1_off	100	0	Yes	Yes	Yes	No	5	5
24	3x36	5x461	nk1_off	100	0	No	No	Yes	No	7	6
25	3x36	Lig	nk1_off	100	0	No	No	Yes	Yes	7	0
26	3x37	3x41	nk1_off	100	0	Yes	No	Yes	No	7	5
27	3x37	4x53	nk1_off	100	0	Yes	No	No	No	7	8
28	3x40	3x41	nk1_off	100	0	No	Yes	Yes	No	7	5
29	3x41	3x44	nk1_off	100	0	Yes	No	No	No	5	7
30	3x41	5x50	nk1_off	100	0	Yes	No	No	No	5	9
31	3x43	6x44	nk1_off	100	0	No	No	Yes	No	8	9
32	3x47	5x54	nk1_off	100	0	No	No	No	No	9	8
33	3x49	3x50	nk1_off	100	0	No	No	No	No	9	9
34	3x50	3x53	nk1_off	100	0	No	No	No	No	9	8
35	3x51	3x56	nk1_off	100	0	Yes	Yes	Yes	Yes	8	6
36	3x52	I2.R141	nk1_off	100	0	No	No	No	Yes	5	5
37	4x56	5x46	nk1_off	100	0	No	No	No	No	5	4
38	4x64	E2.W184	nk1_off	100	0	No	No	Yes	Yes	5	5
39	4x65	E2x52	nk1_off	100	0	No	Yes	Yes	No	5	4
40	E2.T171	E2.V178	nk1_off	100	0	No	No	No	No	5	4
41	E2.E172	E2.E183	nk1_off	100	0	No	No	Yes	No	3	3
42	E2.E183	E2x51	nk1_off	100	0	Yes	No	No	No	3	4
43	E2x52	Lig	nk1_off	100	0	Yes	No	Yes	Yes	4	0
44	5x36	Lig	nk1_off	100	0	Yes	No	Yes	Yes	4	0
45	5x40	5x44	nk1_off	100	0	Yes	No	No	No	5	6
46	5x40	6x56	nk1_off	100	0	Yes	No	No	No	5	5
47	5x40	Lig	nk1_off	100	0	Yes	No	Yes	Yes	5	0
48	5x43	Lig	nk1_off	100	0	Yes	No	Yes	Yes	5	0
49	5x461	Lig	nk1_off	100	0	Yes	No	Yes	Yes	6	0
50	5x47	5x51	nk1_off	100	0	Yes	No	No	No	8	6
51	5x54	6x41	nk1_off	100	0	No	No	No	No	8	8
52	5x58	6x38	nk1_off	100	0	No	Yes	No	No	9	5
53	5x65	6x31	nk1_off	100	0	No	No	Yes	No	8	5
54	6x28	6x31	nk1_off	100	0	No	No	Yes	No	4	5
55	6x32	8x48	nk1_off	100	0	No	No	No	No	8	4
56	6x36	7x53	nk1_off	100	0	No	Yes	Yes	No	8	9
57	6x36	8x47	nk1_off	100	0	No	Yes	No	No	8	8
58	6x37	6x40	nk1_off	100	0	No	Yes	No	No	8	7
59	6x39	7x52	nk1_off	100	0	No	No	No	No	5	8
60	6x40	7x49	nk1_off	100	0	No	No	No	No	7	9
61	6x40	7x52	nk1_off	100	0	No	No	No	No	7	8
62	6x43	7x52	nk1_off	100	0	No	No	No	No	6	8
63	6x47	7x45	nk1_off	100	0	No	No	No	No	8	9
64	6x48	Lig	nk1_off	100	0	Yes	Yes	Yes	Yes	8	0
65	6x52	Lig	nk1_off	100	0	Yes	Yes	Yes	Yes	7	0
66	6x57	6x58	nk1_off	100	0	No	No	No	No	4	4
67	E3.L279	E3.Y278	nk1_off	100	0	No	No	No	Yes	2	2
68	7x39	7x43	nk1_off	100	0	Yes	No	No	No	5	5
69	7x47	7x48	nk1_off	100	0	No	No	No	No	7	5
70	8x48	8x49	nk1_off	100	0	No	No	No	No	4	6
71	2x57	3x27	nk1_off	100	0	Yes	Yes	Yes	No	6	4
72	2x50	6x44	nk1_off	100	0	Yes	Yes	Yes	No	9	9
73	2x62	3x28	nk1_off	100	0	Yes	No	Yes	Yes	6	5
74	2x64	E1x51	nk1_off	100	0	No	Yes	Yes	No	4	2
75	3x22	E1x52	nk1_off	100	0	No	No	Yes	Yes	3	7
76	E3.D276	E3.Y278	nk1_off	100	0	No	No	No	Yes	1	2
77	6x25	6x28	nk1_off	33.3333	0	No	No	No	No	3	4
78	5x61	6x34	nk1_off	33.3333	0	No	Yes	No	No	8	6
79	2x41	4x39	nk1_off	33.3333	0	Yes	No	No	No	5	2
80	1x35	7x39	nk1_off	33.3333	0	Yes	No	Yes	No	4	5
81	I2.Q139	I2.R141	nk1_off	33.3333	0	No	No	No	Yes	4	5
82	5x36	E2.E183	nk1_off	33.3333	0	Yes	No	Yes	No	4	3
83	3x54	3x55	nk1_off	0	0	No	No	Yes	Yes	8	7
84	8x49	I1x50	nk1_off	33.3333	0	No	No	No	No	6	7
85	E1x49	E2.R177	nk1_off	33.3333	0	No	No	Yes	Yes	4	2
86	1x28	NT.Q27	nk1_off	33.3333	0	No	No	No	Yes	2	4
87	2x49	4x50	nk1_off	0	0	No	No	Yes	No	8	9
88	4x45	4x49	nk1_off	0	0	No	No	No	No	5	7
89	6x28	6x32	nk1_off	33.3333	0	No	No	No	No	4	8
90	E2.E186	E2.W184	nk1_off	33.3333	0	No	No	Yes	Yes	3	5
91	3x48	I2.R141	nk1_off	33.3333	0	No	No	No	Yes	5	5
92	I1x49	I1x51	nk1_off	33.3333	0	No	No	Yes	No	5	6
93	2x48	2x53	nk1_off	33.3333	0	Yes	No	Yes	Yes	6	7
94	2x53	3x31	nk1_off	33.3333	0	Yes	Yes	No	No	7	4
95	1x34	1x35	nk1_off	33.3333	0	No	No	Yes	No	4	4
96	5x40	5x41	nk1_off	33.3333	0	Yes	No	No	No	5	5
97	5x31	5x32	nk1_off	33.3333	0	No	No	No	No	1	3
98	6x58	E3.D276	nk1_off	33.3333	0	No	No	No	No	4	1
99	3x23	3x24	nk1_off	33.3333	0	No	No	No	No	3	5
100	2x67	7x31	nk1_off	33.3333	0	Yes	No	No	Yes	5	4
101	7x33	7x37	nk1_off	33.3333	0	No	No	No	No	5	6
102	3x37	4x52	nk1_off	0	0	Yes	No	No	No	7	4
103	5x62	5x66	nk1_off	0	0	No	No	No	No	5	4
104	E3.L277	E3.L279	nk1_off	33.3333	0	No	No	No	No	5	2
105	6x27	6x31	nk1_off	33.3333	0	No	No	Yes	No	2	5
106	5x68	6x27	nk1_off	33.3333	0	No	No	No	No	5	2
107	2x38	I2.L142	nk1_off	0	0	No	No	No	No	6	6
108	1x31	NT.V26	nk1_off	33.3333	0	Yes	Yes	No	No	2	1
109	E2.M174	E2.R177	nk1_off	0	0	No	No	Yes	Yes	1	2
110	7x29	7x32	nk1_off	0	0	No	No	No	Yes	3	1
111	1x46	2x55	nk1_off	0	0	No	No	No	No	8	4
112	6x24	6x31	nk1_off	0	0	No	No	Yes	No	2	5
113	4x43	4x47	nk1_off	0	0	No	No	No	No	2	3
114	5x59	5x60	nk1_off	0	0	No	No	No	No	3	4
115	1x44	1x45	nk1_off	0	0	No	No	No	No	4	4
116	7x55	7x56	nk1_off	0	0	No	No	No	No	6	7
117	8x53	8x56	nk1_off	0	0	No	No	No	No	6	3
118	7x30	7x33	nk1_off	33.3333	0	No	No	No	No	4	5
119	1x41	7x47	nk1_off	0	0	No	No	No	No	5	7
120	E3.K281	E3.L277	nk1_off	0	0	No	No	No	No	2	5
121	8x57	8x58	nk1_off	0	0	No	No	No	No	4	6
122	4x54	4x55	nk1_off	0	0	No	No	No	No	4	4
123	8x51	8x55	nk1_off	0	0	No	No	No	No	8	5
124	5x55	5x59	nk1_off	0	0	No	No	No	No	4	3
125	1x37	1x40	nk1_off	0	0	No	No	No	No	5	4
126	7x51	7x55	nk1_off	0	0	No	No	No	No	7	6
127	5x63	5x67	nk1_off	0	0	No	No	No	No	3	4
128	1x32	1x33	nk1_off	0	0	No	No	No	No	3	4
129	8x56	CT.R321	nk1_off	0	0	No	No	No	No	3	5
130	1x28	1x31	Shared	100	100	No	No	Yes	Yes	2	2
131	1x35	7x35	Shared	100	100	Yes	No	No	No	4	3
132	1x39	2x62	Shared	100	100	No	No	Yes	No	7	6
133	1x39	7x39	Shared	100	100	No	No	Yes	No	7	5
134	1x42	7x39	Shared	100	100	No	No	Yes	No	7	5
135	1x45	7x47	Shared	100	100	No	No	No	No	4	7
136	1x46	7x46	Shared	100	100	No	No	No	No	8	9
137	1x49	7x50	Shared	100	100	No	No	No	No	8	9
138	1x50	2x50	Shared	100	100	Yes	No	Yes	Yes	9	9
139	1x50	2x51	Shared	100	50	Yes	No	No	No	9	7
140	1x50	7x50	Shared	100	100	Yes	No	No	No	9	9
141	1x52	8x54	Shared	100	100	No	No	No	Yes	6	6
142	1x54	2x48	Shared	100	100	No	No	Yes	No	7	6
143	1x55	1x59	Shared	100	100	No	Yes	No	No	4	4
144	1x56	8x53	Shared	100	100	No	Yes	No	No	8	6
145	1x56	8x54	Shared	100	50	No	Yes	No	Yes	8	6
146	1x57	2x40	Shared	100	100	No	No	No	No	7	8
147	1x57	2x44	Shared	100	100	No	No	No	No	7	6
148	1x58	I1x51	Shared	100	100	No	No	Yes	No	2	6
149	1x58	2x44	Shared	100	0	No	No	No	No	2	6
150	1x60	I1x50	Shared	100	50	No	Yes	No	No	5	7
151	I1x48	I1x51	Shared	100	100	No	No	Yes	No	6	6
152	2x37	2x40	Shared	100	100	No	No	No	No	7	8
153	2x41	4x42	Shared	100	100	Yes	No	No	No	5	7
154	2x42	3x45	Shared	100	100	Yes	Yes	No	No	7	7
155	2x42	4x42	Shared	100	100	Yes	Yes	No	No	7	7
156	2x42	4x45	Shared	100	100	Yes	Yes	No	No	7	5
157	2x42	4x46	Shared	100	100	Yes	Yes	No	No	7	8
158	2x43	7x53	Shared	100	100	No	No	Yes	No	8	9
159	2x45	3x42	Shared	100	100	No	No	No	No	9	8
160	2x45	4x46	Shared	100	100	No	No	No	No	9	8
161	2x45	4x50	Shared	100	100	No	No	Yes	No	9	9
162	2x46	2x50	Shared	100	100	No	Yes	Yes	Yes	9	9
163	2x46	3x43	Shared	100	50	No	Yes	No	No	9	8
164	2x48	2x52	Shared	100	100	Yes	No	No	No	6	6
165	2x48	4x50	Shared	100	50	Yes	No	Yes	No	6	9
166	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	9
167	2x50	7x49	Shared	100	100	Yes	Yes	No	No	9	9
168	2x53	3x35	Shared	100	0	Yes	Yes	No	No	7	8
169	2x57	2x61	Shared	100	100	Yes	Yes	No	Yes	6	6
170	2x57	3x32	Shared	100	100	Yes	Yes	No	No	6	6
171	2x58	7x42	Shared	100	100	No	No	No	Yes	7	7
172	2x60	E1x52	Shared	100	100	No	No	Yes	Yes	5	7
173	2x60	3x24	Shared	100	100	No	No	No	No	5	5
174	2x61	3x28	Shared	100	100	No	Yes	Yes	Yes	6	5
175	2x62	2x66	Shared	100	100	Yes	No	No	No	6	5
176	2x63	E1x52	Shared	100	100	No	No	Yes	Yes	4	7
177	2x64	E1x50	Shared	100	100	No	Yes	Yes	Yes	4	8
178	2x66	2x67	Shared	100	100	No	No	Yes	No	5	5
179	2x67	E1x49	Shared	100	100	Yes	No	No	No	5	4
180	E1x49	E1x51	Shared	100	100	No	No	Yes	No	4	2
181	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
182	3x25	E1x50	Shared	100	100	No	Yes	Yes	Yes	9	8
183	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	8	9
184	3x24	3x27	Shared	100	100	No	No	Yes	No	5	4
185	3x25	E2x50	Shared	100	100	No	Yes	No	No	9	9
186	3x27	3x31	Shared	100	100	Yes	No	No	No	4	4
187	3x29	4x65	Shared	100	100	Yes	No	No	Yes	5	5
188	3x29	E2x52	Shared	100	100	Yes	No	Yes	No	5	4
189	3x30	4x54	Shared	100	100	No	No	No	No	6	4
190	3x33	4x61	Shared	100	100	Yes	Yes	Yes	Yes	5	6
191	3x33	Lig	Shared	100	100	Yes	Yes	Yes	Yes	5	0
192	3x36	6x48	Shared	100	100	No	No	Yes	Yes	7	8
193	3x37	5x461	Shared	100	100	Yes	No	Yes	No	7	6
194	3x38	4x50	Shared	100	100	No	No	Yes	No	7	9
195	3x40	5x50	Shared	100	50	No	Yes	No	No	7	9
196	3x40	6x44	Shared	100	100	No	Yes	Yes	No	7	9
197	3x44	5x54	Shared	100	100	No	No	No	No	7	8
198	3x47	5x58	Shared	100	100	No	No	No	Yes	9	9
199	3x51	3x55	Shared	100	100	Yes	Yes	Yes	Yes	8	7
200	3x51	5x56	Shared	100	100	Yes	Yes	No	No	8	4
201	3x51	5x60	Shared	100	100	Yes	Yes	No	No	8	4
202	3x54	5x61	Shared	100	100	No	No	No	Yes	8	8
203	3x55	3x56	Shared	100	100	Yes	Yes	Yes	Yes	7	6
204	3x55	5x64	Shared	100	100	Yes	Yes	No	No	7	5
205	3x56	I2.Q139	Shared	100	100	Yes	Yes	No	No	6	4
206	4x59	4x60	Shared	100	100	No	No	No	No	4	8
207	4x59	4x63	Shared	100	100	No	No	No	No	4	4
208	4x60	5x39	Shared	100	100	No	No	Yes	Yes	8	6
209	4x61	5x39	Shared	100	100	Yes	Yes	Yes	Yes	6	6
210	4x61	Lig	Shared	100	100	Yes	Yes	Yes	Yes	6	0
211	4x63	4x64	Shared	100	100	No	No	No	No	4	5
212	4x64	E2.P185	Shared	100	100	No	No	No	No	5	4
213	E2.M174	E2.P175	Shared	100	100	No	No	No	No	1	2
214	E2.R177	E2.S176	Shared	100	100	Yes	Yes	No	No	2	5
215	E2.R177	E2.V179	Shared	100	100	Yes	Yes	No	No	2	3
216	E2.W184	E2x52	Shared	100	100	Yes	Yes	Yes	No	5	4
217	E2.P185	E2.W184	Shared	100	100	No	No	Yes	Yes	4	5
218	5x36	E2.W184	Shared	100	100	Yes	No	Yes	Yes	4	5
219	5x39	E2.W184	Shared	100	100	Yes	Yes	Yes	Yes	6	5
220	5x32	5x34	Shared	100	100	No	No	No	No	3	1
221	5x37	6x59	Shared	100	100	No	No	No	No	3	5
222	5x39	5x43	Shared	100	100	Yes	Yes	Yes	No	6	5
223	5x40	6x59	Shared	100	100	Yes	No	No	No	5	5
224	5x44	6x52	Shared	100	100	No	No	Yes	Yes	6	7
225	5x44	6x56	Shared	100	100	No	No	No	No	6	5
226	5x461	6x52	Shared	100	100	Yes	No	Yes	Yes	6	7
227	5x47	5x48	Shared	100	100	Yes	No	No	No	8	4
228	5x47	6x49	Shared	100	100	Yes	No	No	No	8	5
229	5x47	6x52	Shared	100	100	Yes	No	Yes	Yes	8	7
230	5x56	5x60	Shared	100	100	No	No	No	No	4	4
231	5x58	6x37	Shared	100	100	No	Yes	No	Yes	9	8
232	5x66	6x31	Shared	100	100	No	No	Yes	No	4	5
233	6x36	7x56	Shared	100	100	No	Yes	No	No	8	7
234	6x43	7x48	Shared	100	100	No	No	No	No	6	5
235	6x44	6x48	Shared	100	100	Yes	No	Yes	Yes	9	8
236	6x47	7x40	Shared	100	50	No	No	No	No	8	7
237	6x48	6x51	Shared	100	100	Yes	Yes	Yes	Yes	8	7
238	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
239	6x48	7x45	Shared	100	100	Yes	Yes	No	No	8	9
240	6x50	7x37	Shared	100	50	No	No	No	No	9	6
241	6x51	6x52	Shared	100	100	Yes	Yes	Yes	Yes	7	7
242	6x51	6x55	Shared	100	100	Yes	Yes	No	No	7	6
243	6x51	7x41	Shared	100	100	Yes	Yes	No	No	7	7
244	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
245	6x54	6x55	Shared	100	100	No	Yes	No	No	4	6
246	6x54	7x34	Shared	100	100	No	Yes	No	Yes	4	5
247	6x55	Lig	Shared	100	100	No	No	Yes	Yes	6	0
248	7x34	7x38	Shared	100	100	No	Yes	No	Yes	5	5
249	7x43	7x48	Shared	100	100	No	No	No	No	5	5
250	7x49	7x53	Shared	100	100	No	No	Yes	No	9	9
251	7x53	8x50	Shared	100	100	Yes	No	Yes	Yes	9	9
252	7x54	8x54	Shared	100	100	No	No	No	Yes	7	6
253	8x47	8x49	Shared	100	100	No	No	No	No	8	6
254	8x47	8x50	Shared	100	100	No	No	Yes	Yes	8	9
255	8x48	8x51	Shared	100	100	No	No	No	No	4	8
256	1x28	1x30	Shared	100	100	No	No	No	No	2	1
257	1x30	1x31	Shared	100	100	No	No	Yes	Yes	1	2
258	4x61	E2x52	Shared	100	100	Yes	Yes	Yes	No	6	4
259	5x35	E2.P185	Shared	100	50	No	No	No	No	4	4
260	5x66	6x35	Shared	33.3333	0	No	No	No	No	4	6
261	1x38	7x39	Shared	66.6667	0	No	No	Yes	No	4	5
262	4x38	4x41	Shared	33.3333	0	No	No	No	No	7	4
263	5x65	6x30	Shared	66.6667	100	No	No	No	No	8	7
264	5x49	5x50	Shared	33.3333	0	No	No	No	No	5	9
265	6x50	7x40	Shared	33.3333	50	No	No	No	No	9	7
266	5x35	E2.H187	Shared	33.3333	100	No	No	No	No	4	2
267	3x33	4x57	Shared	33.3333	50	Yes	Yes	No	No	5	7
268	3x51	5x57	Shared	33.3333	100	Yes	Yes	No	No	8	7
269	1x43	2x58	Shared	66.6667	50	No	No	No	No	6	7
270	1x55	1x60	Shared	33.3333	100	No	Yes	No	Yes	4	5
271	5x33	5x36	Shared	33.3333	100	No	No	Yes	No	2	4
272	1x48	1x49	Shared	66.6667	0	No	No	No	No	4	8
273	3x26	4x65	Shared	33.3333	100	No	No	No	Yes	6	5
274	5x65	6x34	Shared	33.3333	0	No	No	No	No	8	6
275	4x56	5x43	Shared	33.3333	100	No	No	Yes	No	5	5
276	1x56	8x50	Shared	0	100	No	Yes	Yes	Yes	8	9
277	2x53	7x42	Shared	66.6667	100	Yes	Yes	No	Yes	7	7
278	6x49	6x53	Shared	66.6667	100	No	No	No	No	5	6
279	E2.E183	E2.T170	Shared	33.3333	100	Yes	No	No	No	3	4
280	3x25	E2.T171	Shared	0	50	No	Yes	No	No	9	5
281	2x68	E2.R177	Shared	33.3333	100	No	Yes	Yes	Yes	4	2
282	6x61	E3.P275	Shared	33.3333	0	No	No	No	No	4	3
283	1x43	2x59	Shared	66.6667	50	No	No	No	No	6	8
284	4x38	4x40	Shared	33.3333	0	No	No	No	No	7	4
285	E2.T173	E2.V178	Shared	33.3333	100	No	No	No	No	2	4
286	5x51	6x45	Shared	33.3333	0	No	No	No	No	6	5
287	1x32	2x66	Shared	33.3333	100	No	No	No	No	3	5
288	5x31	E2.H187	Shared	33.3333	100	No	No	No	No	1	2
289	4x48	4x52	Shared	0	50	No	No	No	No	3	4
290	2x41	4x43	Shared	33.3333	100	Yes	No	No	No	5	2
291	1x46	2x54	Shared	33.3333	0	No	No	No	No	8	6
292	1x31	7x32	Shared	33.3333	100	Yes	Yes	No	Yes	2	1
293	3x44	5x53	Shared	0	100	No	No	No	No	7	6
294	6x60	6x61	Shared	33.3333	100	No	No	No	No	5	4
295	3x21	E1x50	Shared	0	0	No	No	Yes	Yes	8	8
296	1x36	2x62	Shared	0	0	No	No	Yes	No	6	6
297	3x34	4x53	Shared	0	0	No	No	No	No	5	8
298	I2.P140	I2.Q139	Shared	0	50	No	No	No	No	6	4
299	4x41	I2.L142	Shared	33.3333	0	No	No	No	No	4	6
300	4x51	4x55	Shared	0	0	No	No	No	No	3	4
301	2x65	7x34	Shared	0	0	No	No	No	Yes	5	5
302	1x35	7x36	Shared	0	0	Yes	No	No	No	4	5
303	1x55	8x57	Shared	33.3333	0	No	Yes	No	No	4	4
304	7x30	E3.Y278	Shared	0	100	No	No	No	Yes	4	2
305	5x38	5x42	Shared	0	0	No	No	No	No	4	4
306	1x47	2x55	Shared	0	0	No	Yes	No	No	6	4
307	1x35	7x32	Shared	0	100	Yes	No	No	Yes	4	1
308	6x38	6x42	Shared	0	0	No	No	No	No	5	4
309	1x47	1x51	Shared	0	0	No	Yes	No	No	6	4
310	5x34	5x38	Shared	0	0	No	No	No	No	1	4
311	5x41	5x45	Shared	0	0	No	No	No	No	5	4
312	3x56	I2.P137	Shared	0	0	Yes	Yes	No	No	6	8
313	6x33	6x37	Shared	0	50	No	No	No	Yes	7	8
314	6x61	E3.L277	Shared	0	50	No	No	No	No	4	5
315	7x29	E3.K280	Shared	0	100	No	No	No	No	3	4
316	4x44	4x48	Shared	0	0	No	No	No	No	3	3
317	5x59	5x63	Shared	0	0	No	No	No	No	3	3
318	6x26	6x27	Shared	0	50	No	No	No	No	4	2
319	8x52	8x55	Shared	0	50	No	No	No	No	4	5
320	NT.F25	NT.N23	nk1_on	0	100	No	Yes	No	No	6	0
321	NT.N23	NT.V26	nk1_on	0	100	No	No	No	No	0	1
322	E2.R177	NT.N23	nk1_on	0	100	Yes	Yes	No	No	2	0
323	NT.F25	NT.Q24	nk1_on	0	100	No	Yes	No	No	6	0
324	E3.K281	NT.Q24	nk1_on	0	100	No	No	No	No	2	0
325	Lig	NT.Q24	nk1_on	0	100	Yes	Yes	No	No	0	0
326	2x68	NT.F25	nk1_on	0	100	No	Yes	No	Yes	4	6
327	7x31	NT.F25	nk1_on	0	100	No	Yes	No	Yes	4	6
328	Lig	NT.F25	nk1_on	0	100	Yes	Yes	No	Yes	0	6
329	2x67	NT.V26	nk1_on	0	100	Yes	No	No	No	5	1
330	1x31	NT.Q27	nk1_on	0	100	Yes	Yes	No	Yes	2	4
331	1x32	NT.Q27	nk1_on	0	100	No	No	No	Yes	3	4
332	7x31	NT.Q27	nk1_on	0	100	No	Yes	No	Yes	4	4
333	7x32	NT.Q27	nk1_on	0	100	No	Yes	No	Yes	1	4
334	1x39	7x35	nk1_on	0	100	No	No	No	No	7	3
335	1x46	7x47	nk1_on	0	100	No	No	No	No	8	7
336	1x53	8x50	nk1_on	0	100	No	No	Yes	Yes	8	9
337	1x55	1x56	nk1_on	0	100	No	Yes	No	Yes	4	8
338	1x59	1x60	nk1_on	0	100	No	No	No	Yes	4	5
339	2x37	2x39	nk1_on	0	100	No	No	No	No	7	8
340	2x38	2x41	nk1_on	0	100	No	No	Yes	No	6	5
341	2x38	I2.R141	nk1_on	0	100	No	No	No	Yes	6	5
342	2x39	I2.R141	nk1_on	0	100	No	No	No	Yes	8	5
343	2x42	3x49	nk1_on	0	100	Yes	Yes	No	No	7	9
344	2x46	3x42	nk1_on	0	100	No	Yes	No	No	9	8
345	2x46	7x49	nk1_on	0	100	No	Yes	No	No	9	9
346	2x53	3x36	nk1_on	0	100	Yes	Yes	No	No	7	7
347	2x56	3x31	nk1_on	0	100	No	No	No	No	5	4
348	2x57	3x28	nk1_on	0	100	Yes	Yes	Yes	Yes	6	5
349	2x57	7x38	nk1_on	0	100	Yes	Yes	No	Yes	6	5
350	2x57	7x42	nk1_on	0	100	Yes	Yes	No	Yes	6	7
351	2x60	3x28	nk1_on	0	100	No	No	Yes	Yes	5	5
352	2x61	7x34	nk1_on	0	100	No	Yes	No	Yes	6	5
353	2x61	7x38	nk1_on	0	100	No	Yes	No	Yes	6	5
354	2x61	Lig	nk1_on	0	100	No	Yes	Yes	Yes	6	0
355	2x64	2x68	nk1_on	0	100	No	Yes	No	Yes	4	4
356	2x64	E2.V179	nk1_on	0	100	No	Yes	No	No	4	3
357	2x64	Lig	nk1_on	0	100	No	Yes	Yes	Yes	4	0
358	2x68	Lig	nk1_on	0	100	No	Yes	Yes	Yes	4	0
359	3x24	E1x52	nk1_on	0	100	No	No	Yes	Yes	5	7
360	3x22	E2.T171	nk1_on	0	100	No	No	No	No	3	5
361	3x25	4x65	nk1_on	0	100	No	Yes	No	Yes	9	5
362	3x28	3x32	nk1_on	0	100	Yes	Yes	No	No	5	6
363	3x29	Lig	nk1_on	0	100	Yes	No	Yes	Yes	5	0
364	3x31	3x32	nk1_on	0	100	No	No	No	No	4	6
365	3x33	3x37	nk1_on	0	100	Yes	Yes	Yes	No	5	7
366	3x37	4x56	nk1_on	0	100	Yes	No	No	No	7	5
367	3x40	6x48	nk1_on	0	100	No	Yes	Yes	Yes	7	8
368	3x46	3x50	nk1_on	0	100	No	No	No	No	9	9
369	3x48	3x52	nk1_on	0	100	No	No	No	No	5	5
370	3x49	I2.R141	nk1_on	0	100	No	No	No	Yes	9	5
371	3x50	5x58	nk1_on	0	100	No	No	No	Yes	9	9
372	3x52	3x56	nk1_on	0	100	No	No	Yes	Yes	5	6
373	3x55	5x60	nk1_on	0	100	Yes	Yes	No	No	7	4
374	E2.E172	Lig	nk1_on	0	100	No	No	Yes	Yes	3	0
375	E2.V179	Lig	nk1_on	0	100	No	No	Yes	Yes	3	0
376	E2x51	Lig	nk1_on	0	100	No	No	Yes	Yes	4	0
377	E2.E183	Lig	nk1_on	0	100	Yes	No	Yes	Yes	3	0
378	5x34	E2.H187	nk1_on	0	100	No	No	No	No	1	2
379	5x36	6x59	nk1_on	0	100	Yes	No	No	No	4	5
380	5x39	5x40	nk1_on	0	100	Yes	Yes	Yes	No	6	5
381	5x51	6x44	nk1_on	0	100	No	No	Yes	No	6	9
382	5x54	5x58	nk1_on	0	100	No	No	No	Yes	8	9
383	5x58	6x41	nk1_on	0	100	No	Yes	No	No	9	8
384	5x61	6x37	nk1_on	0	100	No	Yes	No	Yes	8	8
385	5x62	6x34	nk1_on	0	100	No	No	No	No	5	6
386	5x66	6x34	nk1_on	0	100	No	No	No	No	4	6
387	6x32	7x56	nk1_on	0	100	No	No	No	No	8	7
388	6x35	6x38	nk1_on	0	100	No	No	No	No	6	5
389	6x36	7x52	nk1_on	0	100	No	Yes	No	No	8	8
390	6x54	E3.Y278	nk1_on	0	100	No	Yes	No	Yes	4	2
391	6x54	7x30	nk1_on	0	100	No	Yes	No	No	4	4
392	6x54	7x37	nk1_on	0	100	No	Yes	No	No	4	6
393	6x57	E3.Y278	nk1_on	0	100	No	No	No	Yes	4	2
394	6x58	E3.Y278	nk1_on	0	100	No	No	No	Yes	4	2
395	E3.D276	E3.K280	nk1_on	0	100	No	No	No	No	1	4
396	E3.L279	Lig	nk1_on	0	100	No	No	Yes	Yes	2	0
397	7x29	7x33	nk1_on	0	100	No	No	No	No	3	5
398	7x31	7x32	nk1_on	0	100	No	Yes	No	Yes	4	1
399	7x31	Lig	nk1_on	0	100	No	Yes	Yes	Yes	4	0
400	7x34	Lig	nk1_on	0	100	No	Yes	Yes	Yes	5	0
401	7x38	7x42	nk1_on	0	100	No	Yes	No	Yes	5	7
402	8x54	8x58	nk1_on	0	100	No	Yes	No	No	6	6
403	Lig	Lig	nk1_on	0	100	Yes	Yes	Yes	Yes	0	0
404	2x57	Lig	nk1_on	0	100	Yes	Yes	Yes	Yes	6	0
405	3x28	Lig	nk1_on	0	100	Yes	Yes	Yes	Yes	5	0
406	4x42	I2.R141	nk1_on	0	100	No	No	No	Yes	7	5
407	6x57	E3.L277	nk1_on	0	50	No	No	No	No	4	5
408	8x48	8x52	nk1_on	0	50	No	No	No	No	4	4
409	E2.E172	E2.M174	nk1_on	0	50	No	No	No	No	3	1
410	3x39	3x40	nk1_on	0	50	No	No	No	Yes	9	7
411	2x53	7x46	nk1_on	0	50	Yes	Yes	No	No	7	9
412	1x60	8x56	nk1_on	0	50	No	Yes	No	No	5	3
413	2x43	3x46	nk1_on	0	50	No	No	No	No	8	9
414	5x61	5x65	nk1_on	0	50	No	Yes	No	No	8	8
415	6x36	6x37	nk1_on	0	50	No	Yes	No	Yes	8	8
416	4x62	4x65	nk1_on	0	0	No	No	No	Yes	5	5
417	7x54	8x51	nk1_on	0	50	No	No	No	No	7	8
418	3x30	4x59	nk1_on	0	50	No	No	No	No	6	4
419	8x49	I1x49	nk1_on	0	50	No	No	No	No	6	5
420	6x54	7x33	nk1_on	0	0	No	Yes	No	No	4	5
421	1x53	2x47	nk1_on	0	0	No	No	No	No	8	9
422	2x38	4x39	nk1_on	0	0	No	No	No	No	6	2
423	6x43	6x47	nk1_on	0	0	No	No	No	No	6	8
424	3x51	5x61	nk1_on	0	0	Yes	Yes	No	Yes	8	8
425	3x48	I2.L142	nk1_on	0	50	No	No	No	No	5	6
426	3x41	4x49	nk1_on	0	0	Yes	No	No	No	5	7
427	3x41	5x461	nk1_on	0	0	Yes	No	Yes	No	5	6
428	3x34	4x54	nk1_on	0	0	No	No	No	No	5	4
429	6x36	6x40	nk1_on	0	0	No	Yes	No	No	8	7
430	6x23	6x26	nk1_on	0	50	No	No	No	No	0	4
431	E2.E172	E2.T173	nk1_on	0	50	No	No	No	No	3	2
432	5x55	6x41	nk1_on	0	0	No	No	No	No	4	8
433	3x38	4x53	nk1_on	0	0	No	No	No	No	7	8
434	3x41	5x46	nk1_on	0	0	Yes	No	No	No	5	4
435	2x49	3x39	nk1_on	0	0	No	No	No	No	8	9
436	6x23	6x25	nk1_on	0	0	No	No	No	No	0	3
437	6x32	7x55	nk1_on	0	0	No	No	No	No	8	6
438	1x40	1x44	nk1_on	0	0	No	No	No	No	4	4
439	1x41	1x42	nk1_on	0	50	No	No	No	No	5	7
440	5x41	6x56	nk1_on	0	0	No	No	No	No	5	5
441	6x26	6x30	nk1_on	0	0	No	No	No	No	4	7
442	1x30	1x34	nk1_on	0	0	No	No	No	No	1	4
443	1x47	2x54	nk1_on	0	0	No	Yes	No	No	6	6
444	1x51	2x51	nk1_on	0	0	No	No	No	No	4	7
445	1x47	2x51	nk1_on	0	0	No	Yes	No	No	6	7
446	1x43	1x44	nk1_on	0	0	No	No	No	No	6	4
447	1x44	1x48	nk1_on	0	0	No	No	No	No	4	4
448	4x40	4x44	nk1_on	0	0	No	No	No	No	4	3
449	6x39	6x43	nk1_on	0	0	No	No	No	No	5	6
450	4x52	4x55	nk1_on	0	0	No	No	No	No	4	4
451	E2.E183	E2.E186	nk1_on	0	0	Yes	No	No	No	3	3

Orange: nodes, hubs and links specific of nk1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of nk1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	nk1_off Avg Int. Strength	nk1_on Avg Int. Strength	nk1_off Num Of Links	nk1_on Num Of Links	ConSurf
1	1x35	nk1_off	0	0	5	3	4
2	1x50	nk1_off	33.3333	50	4	3	9
3	I1x51	nk1_off	0	0	4	2	6
4	2x41	nk1_off	33.3333	0	4	3	5
5	2x48	nk1_off	0	0	4	3	6
6	2x62	nk1_off	33.3333	0	4	3	6
7	2x67	nk1_off	0	0	4	3	5
8	E1x51	nk1_off	0	0	4	1	2
9	3x27	nk1_off	0	50	4	2	4
10	3x29	nk1_off	66.6667	0	4	3	5
11	3x37	nk1_off	0	0	4	3	7
12	3x41	nk1_off	100	0	4	3	5
13	4x50	nk1_off	33.3333	50	4	3	9
14	E2x52	nk1_off	33.3333	0	5	3	4
15	E2.E183	nk1_off	0	0	4	3	3
16	5x36	nk1_off	33.3333	0	4	3	4
17	5x40	nk1_off	33.3333	0	5	2	5
18	5x43	nk1_off	33.3333	0	4	2	5
19	5x461	nk1_off	66.6667	0	4	3	6
20	5x47	nk1_off	100	50	4	3	8
21	6x31	nk1_off	0	0	5	1	5
22	6x44	nk1_off	0	0	4	3	9
23	7x39	nk1_off	66.6667	0	5	3	5
24	7x53	nk1_off	100	0	5	3	9
25	1x31	Shared	0	50	4	4	2
26	2x42	Shared	100	100	4	5	7
27	2x50	Shared	66.6667	100	6	4	9
28	2x53	Shared	33.3333	50	4	4	7
29	2x57	Shared	33.3333	50	4	6	6
30	E1x50	Shared	100	100	6	5	8
31	E1x52	Shared	66.6667	50	5	4	7
32	3x28	Shared	66.6667	100	4	5	5
33	3x33	Shared	33.3333	100	4	4	5
34	3x51	Shared	33.3333	50	5	5	8
35	3x55	Shared	33.3333	100	4	4	7
36	3x56	Shared	33.3333	0	4	4	6
37	4x61	Shared	100	50	5	4	6
38	E2.R177	Shared	0	0	5	4	2
39	E2.W184	Shared	66.6667	100	6	4	5
40	5x39	Shared	66.6667	100	4	5	6
41	6x48	Shared	100	100	6	6	8
42	6x51	Shared	100	100	5	5	7
43	6x52	Shared	66.6667	100	5	4	7
44	8x50	Shared	66.6667	50	4	4	9
45	Lig	Shared	100	100	13	21	0
46	NT.F25	nk1_on	0	100	0	5	6
47	NT.Q27	nk1_on	0	100	1	4	4
48	1x47	nk1_on	0	0	2	4	6
49	1x55	nk1_on	0	0	3	4	4
50	1x56	nk1_on	0	0	3	4	8
51	1x60	nk1_on	0	50	2	4	5
52	2x46	nk1_on	33.3333	0	2	4	9
53	2x61	nk1_on	0	100	2	5	6
54	2x64	nk1_on	0	50	2	4	4
55	2x68	nk1_on	0	100	1	4	4
56	3x25	nk1_on	0	50	3	4	9
57	3x40	nk1_on	0	0	3	4	7
58	I2.R141	nk1_on	0	0	3	4	5
59	4x65	nk1_on	0	0	3	4	5
60	5x58	nk1_on	66.6667	50	3	5	9
61	5x61	nk1_on	0	0	2	4	8
62	6x36	nk1_on	0	0	3	4	8
63	6x37	nk1_on	0	0	3	4	8
64	6x54	nk1_on	0	100	2	6	4
65	E3.Y278	nk1_on	0	50	3	4	2
66	7x31	nk1_on	0	0	1	4	4
67	7x32	nk1_on	0	0	3	4	1
68	7x34	nk1_on	0	50	3	5	5
69	7x38	nk1_on	66.6667	50	2	4	5
70	7x42	nk1_on	0	50	2	4	7
71	8x54	nk1_on	0	50	3	4	6

Orange: nodes, hubs and links specific of nk1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of nk1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	nk1_off Recurrence	nk1_on Recurrence	nk1_off Hub1?	nk1_on Hub1?	nk1_off Hub2?	nk1_on Hub2?	ConSurf1	ConSurf2
1	1x35	7x39	nk1_off	22.5351	0	Yes	No	Yes	No	4	5
2	1x39	7x39	nk1_off	29.3254	6.36579	No	No	Yes	No	7	5
3	1x39	2x62	nk1_off	23.1586	0.369627	No	No	Yes	No	7	6
4	7x39	7x43	nk1_off	19.3692	0	Yes	No	No	No	5	5
5	7x43	7x48	nk1_off	18.9308	2.19951	No	No	No	No	5	5
6	6x43	7x48	nk1_off	19.7353	4.39445	No	No	No	No	6	5
7	6x43	7x52	nk1_off	20.5278	0	No	No	No	No	6	8
8	6x40	7x52	nk1_off	22.4587	0	No	No	No	No	7	8
9	6x40	7x49	nk1_off	29.2892	0	No	No	No	No	7	9
10	2x62	3x28	nk1_off	37.9219	0	Yes	No	Yes	Yes	6	5
11	2x61	3x28	nk1_off	11.1107	1.05412	No	Yes	Yes	Yes	6	5
12	2x57	2x61	nk1_off	11.6095	1.19558	Yes	Yes	No	Yes	6	6
13	2x57	3x31	nk1_off	27.0888	0	Yes	Yes	No	No	6	4
14	2x53	3x31	nk1_off	33.7463	0	Yes	Yes	No	No	7	4
15	2x48	2x53	nk1_off	31.743	0	Yes	No	Yes	Yes	6	7
16	1x54	2x48	nk1_off	19.5181	1.18189	No	No	Yes	No	7	6
17	1x54	2x44	nk1_off	19.321	0	No	No	No	No	7	6
18	1x57	8x50	nk1_off	28.5289	0	No	No	Yes	Yes	7	9
19	6x36	7x53	nk1_off	43.7508	0	No	Yes	Yes	No	8	9
20	6x36	8x47	nk1_off	40.078	0	No	Yes	No	No	8	8
21	8x47	8x49	nk1_off	91.5081	2.71516	No	No	No	No	8	6
22	8x49	I1x50	nk1_off	13.4438	0	No	No	No	No	6	7
23	1x60	I1x50	nk1_off	11.1871	1.46938	No	Yes	No	No	5	7
24	8x47	8x50	nk1_off	55.1269	4.17085	No	No	Yes	Yes	8	9
25	1x58	2x44	nk1_off	17.0763	7.60245	No	No	No	No	2	6
26	1x58	I1x51	nk1_off	15.9459	5.07895	No	No	Yes	No	2	6
27	2x41	I1x51	nk1_off	12.5548	0	Yes	No	Yes	No	5	6
28	2x48	4x50	nk1_off	16.7746	3.90162	Yes	No	Yes	No	6	9
29	2x38	4x42	nk1_off	12.4422	0	No	No	No	No	6	7
30	3x28	3x29	nk1_off	62.0862	0	Yes	Yes	Yes	No	5	5
31	3x29	4x61	nk1_off	31.0471	0	Yes	No	Yes	Yes	5	6
32	6x48	Lig	nk1_off	84.0903	0	Yes	Yes	Yes	Yes	8	0
33	6x44	6x48	nk1_off	88.4187	4.45834	Yes	No	Yes	Yes	9	8
34	E2x52	Lig	nk1_off	41.671	0	Yes	No	Yes	Yes	4	0
35	2x50	6x44	nk1_off	90.43	0	Yes	Yes	Yes	No	9	9
36	2x57	3x32	nk1_off	20.7209	6.84494	Yes	Yes	No	No	6	6
37	3x28	E1x50	nk1_off	35.9548	0	Yes	Yes	Yes	Yes	5	8
38	E1x50	E1x52	nk1_off	11.2836	2.29534	Yes	Yes	Yes	Yes	8	7
39	2x62	2x66	nk1_off	20.3548	3.46354	Yes	No	No	No	6	5
40	2x66	2x67	nk1_off	12.8082	0.556722	No	No	Yes	No	5	5
41	5x461	Lig	nk1_off	15.7287	0	Yes	No	Yes	Yes	6	0
42	3x37	5x461	nk1_off	15.5598	3.23994	Yes	No	Yes	No	7	6
43	3x37	3x41	nk1_off	12.1566	0	Yes	No	Yes	No	7	5
44	3x40	6x44	nk1_off	11.3842	0.0638861	No	Yes	Yes	No	7	9
45	8x48	8x49	nk1_off	77.8632	0	No	No	No	No	4	6
46	6x32	8x48	nk1_off	69.7735	0	No	No	No	No	8	4
47	6x28	6x32	nk1_off	68.1846	0	No	No	No	No	4	8
48	6x28	6x31	nk1_off	64.0814	0	No	No	Yes	No	4	5
49	5x65	6x31	nk1_off	48.236	0	No	No	Yes	No	8	5
50	5x61	6x34	nk1_off	41.8239	0	No	Yes	No	No	8	6
51	3x54	5x61	nk1_off	39.6717	1.44656	No	No	No	Yes	8	8
52	3x54	3x55	nk1_off	37.95	0	No	No	Yes	Yes	8	7
53	3x51	5x60	nk1_off	11.3802	1.38724	Yes	Yes	No	No	8	4
54	3x56	I2.Q139	nk1_off	11.4003	2.94332	Yes	Yes	No	No	6	4
55	5x36	Lig	nk1_off	21.449	0	Yes	No	Yes	Yes	4	0
56	5x36	E2.W184	nk1_off	13.9587	7.27845	Yes	No	Yes	Yes	4	5
57	E1x49	E2.R177	nk1_off	19.9847	0	No	No	Yes	Yes	4	2
58	5x31	E2.H187	nk1_off	12.4663	3.76472	No	No	No	No	1	2
59	5x40	Lig	nk1_off	11.871	0	Yes	No	Yes	Yes	5	0
60	6x52	Lig	nk1_off	13.295	0	Yes	Yes	Yes	Yes	7	0
61	5x47	6x52	nk1_off	15.2741	6.01898	Yes	No	Yes	Yes	8	7
62	6x48	7x45	nk1_off	29.4783	1.51501	Yes	Yes	No	No	8	9
63	6x47	7x45	nk1_off	27.668	0	No	No	No	No	8	9
64	7x33	7x37	nk1_off	20.3468	0	No	No	No	No	5	6
65	7x30	7x33	nk1_off	18.4963	0	No	No	No	No	4	5
66	7x30	E3.Y278	nk1_off	16.6057	0.0273798	No	No	No	Yes	4	2
67	3x32	Lig	nk1_off	21.2197	0	No	No	Yes	Yes	6	0
68	E1x49	E1x51	nk1_off	15.7891	1.72492	No	No	Yes	No	4	2
69	E1x51	E1x52	nk1_off	11.6175	0	Yes	No	Yes	Yes	2	7
70	1x35	7x32	Shared	14.6667	12.1338	Yes	No	No	Yes	4	1
71	2x50	7x49	Shared	87.8354	68.7825	Yes	Yes	No	No	9	9
72	7x49	7x53	Shared	100	84.5213	No	No	Yes	No	9	9
73	7x53	8x50	Shared	56.8205	29.2872	Yes	No	Yes	Yes	9	9
74	1x57	2x44	Shared	26.6101	10.1168	No	No	No	No	7	6
75	2x45	4x50	Shared	13.5766	11.8737	No	No	Yes	No	9	9
76	2x45	4x46	Shared	11.4526	38.5918	No	No	No	No	9	8
77	2x42	4x46	Shared	10.3866	37.5148	Yes	Yes	No	No	7	8
78	4x61	Lig	Shared	30.3954	40.7456	Yes	Yes	Yes	Yes	6	0
79	3x29	E2x52	Shared	31.4534	15.4696	Yes	No	Yes	No	5	4
80	6x54	7x34	Shared	11.9675	28.2057	No	Yes	No	Yes	4	5
81	6x54	6x55	Shared	13.7335	15.1273	No	Yes	No	No	4	6
82	6x55	Lig	Shared	10.0205	13.6077	No	No	Yes	Yes	6	0
83	6x48	6x51	Shared	10.1935	18.0798	Yes	Yes	Yes	Yes	8	7
84	5x65	6x34	Shared	43.972	10.1214	No	No	No	No	8	6
85	3x51	3x55	Shared	17.9171	23.5192	Yes	Yes	Yes	Yes	8	7
86	3x55	3x56	Shared	15.6804	20.9911	Yes	Yes	Yes	Yes	7	6
87	E2.W184	E2x52	Shared	17.6435	27.503	Yes	Yes	Yes	No	5	4
88	E2.P185	E2.W184	Shared	19.7554	31.4046	No	No	Yes	Yes	4	5
89	5x35	E2.P185	Shared	17.3981	25.7826	No	No	No	No	4	4
90	5x35	E2.H187	Shared	14.9362	22.4742	No	No	No	No	4	2
91	6x47	7x40	Shared	25.8498	10.9245	No	No	No	No	8	7
92	6x50	7x40	Shared	24.0235	13.083	No	No	No	No	9	7
93	6x50	7x37	Shared	22.1891	15.2323	No	No	No	No	9	6
94	7x31	NT.Q27	nk1_on	0	13.5165	No	Yes	No	Yes	4	4
95	7x31	7x32	nk1_on	0	19.3712	No	Yes	No	Yes	4	1
96	2x53	7x46	nk1_on	0	100	Yes	Yes	No	No	7	9
97	2x53	7x42	nk1_on	4.90366	84.3023	Yes	Yes	No	Yes	7	7
98	2x57	7x42	nk1_on	0	71.8901	Yes	Yes	No	Yes	6	7
99	2x57	Lig	nk1_on	0	69.7545	Yes	Yes	Yes	Yes	6	0
100	2x50	7x46	nk1_on	9.94006	96.1395	Yes	Yes	No	No	9	9
101	1x56	8x54	nk1_on	4.28014	11.2987	No	Yes	No	Yes	8	6
102	1x56	8x50	nk1_on	9.61422	21.8399	No	Yes	Yes	Yes	8	9
103	2x45	3x42	nk1_on	1.24703	42.6394	No	No	No	No	9	8
104	2x46	3x42	nk1_on	0	43.6388	No	Yes	No	No	9	8
105	2x46	2x50	nk1_on	2.38143	29.1366	No	Yes	Yes	Yes	9	9
106	1x57	2x40	nk1_on	2.5705	12.6312	No	No	No	No	7	8
107	2x37	2x40	nk1_on	1.28726	15.1364	No	No	No	No	7	8
108	2x37	2x39	nk1_on	0	17.628	No	No	No	No	7	8
109	2x39	I2.R141	nk1_on	0	20.0876	No	No	No	Yes	8	5
110	3x49	I2.R141	nk1_on	0	13.6625	No	No	No	Yes	9	5
111	2x42	3x49	nk1_on	0	14.6527	Yes	Yes	No	No	7	9
112	4x42	I2.R141	nk1_on	0	13.5119	No	No	No	Yes	7	5
113	2x42	4x42	nk1_on	9.53779	19.5628	Yes	Yes	No	No	7	7
114	3x36	6x48	nk1_on	1.78205	17.2264	No	No	Yes	Yes	7	8
115	6x51	Lig	nk1_on	1.46426	16.0035	Yes	Yes	Yes	Yes	7	0
116	7x34	7x38	nk1_on	9.21598	15.8027	No	Yes	No	Yes	5	5
117	7x34	Lig	nk1_on	0	14.566	No	Yes	Yes	Yes	5	0
118	2x64	E1x50	nk1_on	9.77111	10.596	No	Yes	Yes	Yes	4	8
119	2x64	Lig	nk1_on	0	10.9565	No	Yes	Yes	Yes	4	0
120	3x29	Lig	nk1_on	0	23.0446	Yes	No	Yes	Yes	5	0
121	4x61	E2x52	nk1_on	0.506859	15.0817	Yes	Yes	Yes	No	6	4
122	4x61	5x39	nk1_on	4.94388	26.7728	Yes	Yes	Yes	Yes	6	6
123	6x51	6x52	nk1_on	6.07024	17.8744	Yes	Yes	Yes	Yes	7	7
124	3x50	5x58	nk1_on	0	62.5262	No	No	No	Yes	9	9
125	3x46	3x50	nk1_on	0	63.3568	No	No	No	No	9	9
126	2x43	3x46	nk1_on	0	64.2055	No	No	No	No	8	9
127	2x43	7x53	nk1_on	1.63321	65.0406	No	No	Yes	No	8	9
128	3x48	3x52	nk1_on	0	14.1462	No	No	No	No	5	5
129	3x52	3x56	nk1_on	0	15.5334	No	No	Yes	Yes	5	6
130	3x51	5x61	nk1_on	0	28.7989	Yes	Yes	No	Yes	8	8
131	5x61	6x37	nk1_on	0	46.6597	No	Yes	No	Yes	8	8
132	5x58	6x37	nk1_on	6.32367	55.6083	No	Yes	No	Yes	9	8
133	5x39	E2.W184	nk1_on	1.05797	15.2186	Yes	Yes	Yes	Yes	6	5
134	5x34	E2.H187	nk1_on	0	15.0178	No	No	No	No	1	2
135	5x61	5x65	nk1_on	0	18.0068	No	Yes	No	No	8	8
136	6x54	7x37	nk1_on	0	17.3725	No	Yes	No	No	4	6
137	6x57	E3.Y278	nk1_on	0	10.9108	No	No	No	Yes	4	2
138	6x54	E3.Y278	nk1_on	0	14.5569	No	Yes	No	Yes	4	2
139	4x38	4x41	nk1_on	2.59463	10.1533	No	No	No	No	7	4
140	4x41	I2.L142	nk1_on	3.88189	11.5679	No	No	No	No	4	6
141	3x48	I2.L142	nk1_on	0	12.7498	No	No	No	No	5	6
142	7x31	Lig	nk1_on	0	33.2892	No	Yes	Yes	Yes	4	0
143	2x53	3x36	nk1_on	0	17.1534	Yes	Yes	No	No	7	7
144	7x38	7x42	nk1_on	0	15.7981	No	Yes	No	Yes	5	7
145	2x46	7x49	nk1_on	0	16.5556	No	Yes	No	No	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x57	2x61	Shared	4.08667	8.175	5	1	1	1
2x57	3x31	nk1_off	6.04	0	5	1	1	2
2x57	3x32	Shared	7.6	4.89	5	1	1	1
2x61	3x28	Shared	8.92667	10.2	0	1	1	1
2x64	E1x50	Shared	8.03667	10.13	0	1	1	2
2x67	E1x51	nk1_off	7.26	0	7	0	2	2
3x28	E1x50	nk1_off	7.40667	0	0	1	1	2
3x27	3x31	Shared	12.1467	8.035	5	0	2	2
3x28	3x29	nk1_off	8.08	0	0	1	1	1
3x29	4x61	nk1_off	6.6	0	1	1	1	1
3x29	4x65	Shared	5.46333	5.96	1	1	1	2
3x29	E2x52	Shared	6.61	4.245	1	1	1	1
3x32	Lig	nk1_off	11.4233	0	0	1	1	0
3x33	4x61	Shared	5.49	5.49	1	1	1	1
3x33	5x43	nk1_off	4.61	0	1	1	1	1
3x33	Lig	Shared	7.31667	9.705	1	1	1	0
3x36	5x461	nk1_off	6.05667	0	1	0	1	1
3x36	6x48	Shared	6.03	4.29	1	0	1	1
3x36	Lig	nk1_off	4.78667	0	1	0	1	0
3x37	3x41	nk1_off	18.0467	0	0	0	2	2
3x37	5x461	Shared	3.77	10.675	0	0	2	1
3x40	3x41	nk1_off	3.59333	0	8	1	2	2
3x40	6x44	Shared	10.4667	5.025	8	1	2	2
4x61	5x39	Shared	7.51333	12.965	1	1	1	2
4x61	Lig	Shared	19.2133	8.84	1	1	1	0
4x65	E2x52	nk1_off	4.64333	0	1	0	2	1
E2.E172	E2.E183	nk1_off	3.80667	0	0	1	1	1
E2.R177	E2.V179	Shared	3.48667	4.575	0	0	2	1
E2.E183	E2x51	nk1_off	5.86	0	0	1	1	1
E2.W184	E2x52	Shared	6.65333	13.51	1	0	2	1
E2x52	Lig	nk1_off	3.64333	0	1	0	1	0
5x36	E2.W184	Shared	14.1767	17.45	0	0	1	2
5x39	E2.W184	Shared	5.46667	10.61	0	0	2	2
5x36	Lig	nk1_off	4.18667	0	0	0	1	0
5x39	5x43	Shared	5.88667	6.94	0	0	2	1
5x40	5x44	nk1_off	3.65333	0	1	0	1	2
5x40	6x56	nk1_off	4.71667	0	1	0	1	2
5x40	6x59	Shared	6.53333	14.155	1	0	1	2
5x40	Lig	nk1_off	13.9967	0	1	0	1	0
5x43	Lig	nk1_off	3.71	0	1	0	1	0
5x44	6x52	Shared	9.12667	10.95	1	0	2	1
5x44	6x56	Shared	5.40333	5.16	1	0	2	2
5x461	6x52	Shared	3.97667	4.64	1	0	1	1
5x461	Lig	nk1_off	5.25667	0	1	0	1	0
5x47	6x52	Shared	6.89667	9.255	0	0	2	1
6x44	6x48	Shared	10.3567	7.015	0	1	2	1
6x48	6x51	Shared	8.68667	10.52	1	1	1	1
6x48	7x41	Shared	5.18667	5.835	1	1	1	2
6x48	7x45	Shared	6.58667	4.94	1	1	1	2
6x48	Lig	nk1_off	5.60667	0	1	1	1	0
6x51	6x52	Shared	3.77	4.525	1	1	1	1
6x51	6x55	Shared	8.93333	11.255	1	1	1	1
6x51	7x41	Shared	4.62333	4.855	1	1	1	2
6x51	Lig	Shared	19.1133	5.595	1	1	1	0
6x52	Lig	nk1_off	5.50333	0	1	0	1	0
6x54	6x55	Shared	8.93333	9.11	0	1	2	1
6x54	7x34	Shared	7.56333	9.8	0	1	2	1
6x55	Lig	Shared	18.56	11.95	1	1	1	0
E3.L279	E3.Y278	nk1_off	8.98667	0	0	0	1	2
7x34	7x38	Shared	9.98	7.18	0	1	1	2
2x57	3x27	nk1_off	4.83333	0	5	1	1	2
4x61	E2x52	Shared	4.11667	4.8	1	1	1	1
2x62	3x28	nk1_off	3.77	0	0	0	2	1
2x64	E1x51	nk1_off	4.63333	0	0	1	1	2
3x33	4x57	Shared	3.25	3.25	1	1	1	2
5x33	5x36	Shared	3.15	8.775	0	0	2	1
4x56	5x43	Shared	2.98	3.725	0	0	2	1
5x36	E2.E183	nk1_off	2.96	0	0	0	1	1
2x53	7x42	Shared	2.88667	5.055	0	0	2	2
E2.E183	E2.T170	Shared	2.82	11.285	0	1	1	2
2x68	E2.R177	Shared	2.81333	8.44	0	1	1	2
E2.E186	E2.W184	nk1_off	2.54333	0	0	0	2	2
2x53	3x31	nk1_off	2.48667	0	0	0	2	2
5x40	5x41	nk1_off	2.21	0	1	0	1	2
2x67	7x31	nk1_off	2.06	0	7	0	2	1
E3.L277	E3.L279	nk1_off	1.84667	0	0	0	2	1
2x65	7x34	Shared	1.33333	2.67	0	0	2	1
E2.M174	E2.R177	nk1_off	1.24	0	0	0	2	2
E3.K281	E3.L277	nk1_off	0.94	0	0	0	2	2
NT.F25	NT.N23	nk1_on	0	6.04	0	1	1	2
E2.R177	NT.N23	nk1_on	0	13.86	0	0	2	2
NT.F25	NT.Q24	nk1_on	0	11.71	0	1	1	1
E3.K281	NT.Q24	nk1_on	0	7.46	0	0	2	1
Lig	NT.Q24	nk1_on	0	7.68	1	1	0	1
2x68	NT.F25	nk1_on	0	7.855	0	1	1	1
7x31	NT.F25	nk1_on	0	8.785	0	1	1	1
Lig	NT.F25	nk1_on	0	14.47	1	1	0	1
7x31	NT.Q27	nk1_on	0	12.8	0	1	1	2
7x32	NT.Q27	nk1_on	0	3.84	0	1	2	2
2x53	3x36	nk1_on	0	7.605	0	0	2	1
2x57	3x28	nk1_on	0	5.74	5	1	1	1
2x57	7x38	nk1_on	0	3.505	5	1	1	2
2x57	7x42	nk1_on	0	3.505	5	1	1	2
2x60	3x28	nk1_on	0	13.145	0	1	2	1
2x61	7x34	nk1_on	0	6.395	0	1	1	1
2x61	7x38	nk1_on	0	4.91	0	1	1	2
2x61	Lig	nk1_on	0	5.83	0	1	1	0
2x64	2x68	nk1_on	0	5.235	0	1	1	1
2x64	E2.V179	nk1_on	0	4.415	0	1	1	1
2x64	Lig	nk1_on	0	7.855	0	1	1	0
2x68	Lig	nk1_on	0	13.29	0	1	1	0
3x28	3x32	nk1_on	0	6.865	0	1	1	1
3x29	Lig	nk1_on	0	5.495	1	1	1	0
3x31	3x32	nk1_on	0	5.78	5	0	2	1
3x33	3x37	nk1_on	0	5.02	1	1	1	2
3x37	4x56	nk1_on	0	9.745	0	0	2	2
3x40	6x48	nk1_on	0	5.875	8	1	2	1
E2.E172	Lig	nk1_on	0	4.89	0	1	1	0
E2.V179	Lig	nk1_on	0	9.18	0	1	1	0
E2x51	Lig	nk1_on	0	12.685	0	0	1	0
E2.E183	Lig	nk1_on	0	3.49	0	1	1	0
5x36	6x59	nk1_on	0	9.54	0	0	1	2
5x39	5x40	nk1_on	0	5.445	0	0	2	1
6x54	E3.Y278	nk1_on	0	12.895	0	1	2	2
E3.L279	Lig	nk1_on	0	11	0	0	1	0
7x31	7x32	nk1_on	0	5.12	0	1	1	2
7x31	Lig	nk1_on	0	4.685	0	1	1	0
7x34	Lig	nk1_on	0	11.845	0	1	1	0
7x38	7x42	nk1_on	0	6.5	0	1	2	2
2x57	Lig	nk1_on	0	5.135	5	1	1	0
3x28	Lig	nk1_on	0	5.775	0	1	1	0
E2.E172	E2.M174	nk1_on	0	3.385	0	1	1	2
3x41	5x461	nk1_on	0	2.42	8	0	2	1
E2.E172	E2.T173	nk1_on	0	2.115	0	1	1	2
5x41	6x56	nk1_on	0	1.43	0	0	2	2
E2.E183	E2.E186	nk1_on	0	0.635	0	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	nk1_off	6J20-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
	nk1_on	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2

Network Difference
Value	nk1_off	nk1_on
I_min	3.48	3.46
Number of Linked Nodes	282	275
Number of Specific Nodes	11 (3.90%)	4 (1.45%)
Number of Shared Nodes	271 (96.10%)	271 (98.55%)
Number of Links	319	322
Number of Specific Links	129 (40.44%)	132 (40.99%)
Number of Shared Links	190 (59.56%)	190 (59.01%)
Number of Hubs	45	47
Number of Specific Hubs	24 (53.33%)	26 (55.32%)
Number of Shared Hubs	21 (46.67%)	21 (44.68%)
Average % Shared Neighbours (Jaccard)	48.05
Average % Shared Neighbours (Otsuka)	57.99
Average % Shared Neighbours (Overlap Coefficient)	67.58
Average % Shared Cliques (k3-6)	53.33
Graphlets Similarity	0.665193

Paths Difference
Value	nk1_off	nk1_on
Number Of Nodes in MetaPath	89	70
Specific Nodes in MetaPath	48 (53.93%)	29 (41.43%)
Shared Nodes in MetaPath	271 (96.10%)	271 (96.10%)
Number Of Links MetaPath	93	76
Specific Links in MetaPath	69 (74.19%)	52 (68.42%)
Shared Links in MetaPath	190 (59.56%)	190 (59.56%)
Number of Shortest Paths	66539	53261
Length Of Smallest Path	3	3
Average Path Length	13.9813	13.226
Length of Longest Path	34	37
Minimum Path Strength	0.523333	0.7975
Average Path Strength	5.84809	6.34686
Maximum Path Strength	19.1633	18.8675
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.915899	0.92027
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.44828	3.57143
Average % Of Corr. Nodes	42.428	47.638
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	44.9906	46.0462
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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