Orange: nodes, hubs and links specific of npy1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of npy1_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner npy1_off Avg Int. Strength npy1_on Avg Int. Strength npy1_off Num Of Links npy1_on Num Of Links ConSurf
12x61 npy1_off9.306255.64436
23x30 npy1_off6.9187510.43436
33x39 npy1_off4.756254.89419
43x41 npy1_off6.2615.81333537
53x50 npy1_off7.211256.2439
6E2.Q201 npy1_off6.39753.905423
75x39 npy1_off12.04259.32436
85x461 npy1_off5.1612511.2426
96x36 npy1_off5.41259.9418
106x37 npy1_off4.557511.72418
116x58 npy1_off7.12624.11514
128x58 npy1_off2.4651.195425
131x39 Shared10.7726.244557
141x50 Shared4.036259.268459
152x57 Shared5.5797.7567
16E1x50 Shared9.60411.6275548
17E1x52 Shared9.913758.584457
183x32 Shared5.5298.462556
193x49 Shared6.046675.24648
204x61 Shared7.736257.03445
21E2.F202 Shared7.15810.82545
225x36 Shared7.29212.3625544
235x47 Shared6.7557.798458
246x48 Shared8.1287.838558
256x54 Shared9.511257.11445
26E3.H290 Shared8.264.7025444
277x38 Shared9.25.3275446
287x53 Shared9.223753.845469
298x50 Shared5.6876.175548
30Lig Shared9.1057719.004413390
312x42 npy1_on5.27754.835247
322x46 npy1_on5.71756.934259
332x551 npy1_on4.566.1275145
342x59 npy1_on7.8959.405346
353x28 npy1_on7.319.16155
363x51 npy1_on8.806675.985347
373x55 npy1_on8.7555.55356
38E2.M179 npy1_on7.383335.685344
39E2.P183 npy1_on4.845.415241
40E2.Y192 npy1_on1.7255.26141
41E2x51 npy1_on5.596675.745343
42E2x52 npy1_on4.933338.3575344
435x57 npy1_on5.592.8225147
445x58 npy1_on5.243338.038359
456x26 npy1_on1.70758.85244
466x60 npy1_on8.95755.1725244
477x52 npy1_on5.166.382358
488x54 npy1_on4.56751.862255
   
Orange: nodes, hubs and links specific of npy1_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of npy1_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner npy1_off Recurrence npy1_on Recurrence npy1_off Hub1? npy1_on Hub1? npy1_off Hub2? npy1_on Hub2? ConSurf1 ConSurf2
11x32 2x65 npy1_off16.12630NoNoNoNo34
22x61 2x65 npy1_off18.0952.11941YesNoNoNo64
31x39 2x61 npy1_off27.77934.21902YesYesYesNo76
41x39 7x38 npy1_off28.50623.8455YesYesYesYes76
57x34 7x38 npy1_off20.81190NoNoYesYes56
66x58 7x30 npy1_off17.32560YesNoNoNo43
77x27 7x30 npy1_off15.59030NoNoNoNo13
87x27 NT.N30 npy1_off11.70070NoNoNoNo16
97x34 Lig npy1_off19.58081.04131NoNoYesYes50
106x58 Lig npy1_off23.00341.04697YesNoYesYes40
111x32 NT.L35 npy1_off12.15710NoNoNoNo33
121x28 NT.L35 npy1_off10.15657.22694NoNoNoNo43
133x32 7x42 npy1_off46.13430YesYesNoNo67
143x32 Lig npy1_off40.61554.42841YesYesYesYes60
151x39 7x39 npy1_off12.15711.06112YesYesNoNo75
161x50 7x50 npy1_off10.28921.06112YesYesNoNo99
171x50 2x50 npy1_off91.55217.32598YesYesNoNo99
182x50 3x39 npy1_off94.61930NoNoYesNo99
193x39 6x44 npy1_off1000YesNoNoNo99
203x32 6x48 npy1_off61.48050YesYesYesYes68
211x50 2x47 npy1_off75.57972.11375YesYesNoNo99
221x53 7x53 npy1_off23.82060NoNoYesYes99
232x40 7x53 npy1_off62.01650NoNoYesYes89
241x57 2x40 npy1_off67.19550NoNoNoNo78
251x57 2x44 npy1_off68.89364.13979NoNoNoNo75
261x54 2x44 npy1_off70.58110NoNoNoNo75
271x54 2x47 npy1_off73.92411.06112NoNoNoNo79
281x53 8x50 npy1_off21.8360NoNoYesYes98
298x47 8x49 npy1_off10.25744.11432NoNoNoNo86
306x36 8x47 npy1_off23.99040YesNoNoNo88
316x36 7x53 npy1_off37.25660YesNoYesYes89
322x39 3x49 npy1_off46.95681.37804NoNoYesYes78
332x39 6x37 npy1_off48.23560NoNoYesNo78
343x46 6x37 npy1_off57.60680NoNoYesNo88
352x42 3x45 npy1_off59.9318.23147NoYesNoNo77
363x45 4x49 npy1_off62.21286.87323NoNoNoNo77
373x41 4x49 npy1_off63.37495.50934YesNoNoNo77
383x41 5x461 npy1_off56.37040YesNoYesNo76
393x36 5x461 npy1_off60.02120NoNoYesNo76
404x38 4x41 npy1_off11.03741.3837NoNoNoNo74
413x49 4x41 npy1_off12.39060YesYesNoNo84
423x38 4x50 npy1_off14.51311.3837NoNoNoNo79
432x49 3x38 npy1_off16.07320NoNoNoNo87
442x49 3x35 npy1_off10.91540NoNoNoNo88
452x53 3x35 npy1_off11.8442.26655NoNoNoNo78
462x53 3x32 npy1_off13.12820NoNoYesYes76
472x57 2x58 npy1_off25.35951.06112YesYesNoNo78
482x58 2x59 npy1_off23.90020NoNoNoYes86
49E2x52 Lig npy1_off42.15975.99887NoYesYesYes40
504x65 E2x52 npy1_off36.2591.03848NoNoNoYes54
514x65 E2x50 npy1_off37.68110NoNoNoNo59
52E1x50 E2x50 npy1_off27.43430YesYesNoNo89
53E1x50 E1x52 npy1_off25.93799.47934YesYesYesYes87
54E1x51 E1x52 npy1_off40.53598.53707NoNoYesYes27
552x67 E2.K195 npy1_off29.88060NoNoNoNo43
56E1x49 E2.K195 npy1_off36.65690NoNoNoNo53
57E1x49 E1x51 npy1_off37.97290NoNoNoNo52
584x61 Lig npy1_off19.88336.0498YesYesYesYes50
593x34 4x57 npy1_off11.5844.17374NoNoNoNo57
603x33 4x57 npy1_off13.47846.22807NoNoNoNo47
613x33 4x61 npy1_off15.36220.135823NoNoYesYes45
623x40 6x44 npy1_off25.64610NoNoNoNo79
633x41 5x50 npy1_off24.66970YesNoNoNo79
643x41 3x44 npy1_off15.64870YesNoNoNo77
653x49 I2.W148 npy1_off29.610YesYesNoNo85
663x55 3x56 npy1_off21.08784.12564NoYesNoNo66
673x52 3x56 npy1_off25.44974.06621NoNoNoNo46
683x52 I2.W148 npy1_off28.30460NoNoNoNo45
693x55 5x64 npy1_off10.53865.35937NoYesNoNo65
70E2.F202 E2x52 npy1_off15.7234.09451YesYesNoYes54
712x67 E2.V187 npy1_off27.17430NoNoNoNo42
72E2.V187 NT.F28 npy1_off24.58480NoNoNoNo26
73E2.F184 NT.F28 npy1_off23.27410NoNoNoNo16
74E2.F184 E2x51 npy1_off20.36080NoNoNoYes13
75E2.V197 E2x51 npy1_off13.32451.05546NoNoNoYes43
76E2.P183 E2.V197 npy1_off11.81750.950764NoYesNoNo14
77E2.P183 E2.T180 npy1_off10.29980NoYesNoNo13
785x36 6x59 npy1_off20.9180.0311262YesYesNoNo44
796x59 Lig npy1_off22.43571.01868NoNoYesYes40
805x36 5x37 npy1_off11.48850YesYesNoNo43
815x47 6x52 npy1_off12.88411.04697YesYesNoNo88
826x52 Lig npy1_off14.68290NoNoYesYes80
836x32 8x47 npy1_off12.30030NoNoNoNo78
846x36 6x40 npy1_off10.28920YesNoNoNo87
858x50 8x54 npy1_off12.07750YesYesNoYes85
868x54 8x58 npy1_off10.28924.13979NoYesYesNo55
871x39 2x57 npy1_off16.13164.50198YesYesYesYes77
887x38 7x42 npy1_off11.69010YesYesNoNo67
892x59 E1x52 npy1_off21.33724.82739NoYesYesYes67
903x40 5x50 npy1_off24.2774.16242NoNoNoNo79
912x57 7x42 Shared35.351699.9491YesYesNoNo77
926x44 6x48 Shared80.440419.9179NoNoYesYes98
933x36 6x48 Shared34.587427.2524NoNoYesYes78
943x36 Lig Shared79.20430.6338NoNoYesYes70
952x42 3x46 Shared58.774230.4556NoYesNoNo78
967x38 Lig npy1_on095.399YesYesYesYes60
972x57 7x38 npy1_on095.1896YesYesYesYes76
987x55 8x54 npy1_on013.4748NoNoNoYes65
997x51 7x55 npy1_on2.0748214.8048NoNoNoNo66
1007x51 7x52 npy1_on016.129NoNoNoYes68
1016x40 7x52 npy1_on8.2515323.9587NoNoNoYes78
1026x40 7x53 npy1_on025.232NoNoYesYes79
1032x46 7x53 npy1_on049.3435NoYesYesYes99
1042x46 7x49 npy1_on2.0748250.6338NoYesNoNo99
1052x50 7x49 npy1_on099.6944NoNoNoNo99
1062x50 7x46 npy1_on2.0748299.9887NoNoNoNo98
1077x42 7x46 npy1_on0100NoNoNoNo78
1083x43 7x53 npy1_on048.6616NoNoYesYes89
1093x43 7x49 npy1_on048.9955NoNoNoNo89
1101x57 2x43 npy1_on020.2009NoNoNoNo78
1112x43 7x53 npy1_on2.053621.5025NoNoYesYes89
1121x57 8x50 npy1_on014.9349NoNoYesYes78
1133x46 7x53 npy1_on029.8783NoNoYesYes89
1142x42 4x46 npy1_on012.2722NoYesNoNo77
1153x28 Lig npy1_on025.348NoYesYesYes50
1163x28 E1x50 npy1_on014.9491NoYesYesYes58
1172x63 E1x50 npy1_on1.9156314.6435NoNoYesYes68
1182x63 Lig npy1_on015.4301NoNoYesYes60
1193x25 E1x50 npy1_on2.0642118.8144NoNoYesYes98
1203x25 E2.M179 npy1_on9.3605715.0736NoNoNoYes94
1213x50 7x53 npy1_on032.06YesNoYesYes99
1223x47 5x58 npy1_on1.6078527.7419NoNoNoYes99
1233x50 5x58 npy1_on032.708YesNoNoYes99
1243x51 5x57 npy1_on021.378NoYesNoYes77
1253x47 5x57 npy1_on026.528NoNoNoYes97
1263x51 3x55 npy1_on9.5144613.3616NoYesNoYes76
1275x44 5x47 npy1_on010.2122NoNoYesYes68
1285x47 5x51 npy1_on3.7304318.0277YesYesNoNo86
1295x51 6x44 npy1_on018.9757NoNoNoNo69

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
7x28NT.C33Shared6.377.280112
1x392x57Shared5.2757.030122
1x397x38Shared8.1654.360121
2x533x32npy1_off7.16500021
2x577x42Shared12.01516.960122
2x603x28npy1_off7.3100111
2x607x38Shared11.6355.480111
2x63E1x50Shared13.50513.50112
2x647x31npy1_off4.3900021
2x67E2.T188npy1_off4.33500011
3x294x61Shared6.55.780021
3x294x65Shared1514.210022
3x326x48npy1_off7.1200112
3x327x42npy1_off4.0800112
3x32LigShared5.46513.150110
3x334x57Shared6.893.440112
3x334x61Shared5.599.780111
3x366x48Shared10.577.050112
3x36LigShared8.686.030110
3x375x461npy1_off7.79500021
3x415x461npy1_off6.5700021
4x615x39Shared9.87.220112
4x61LigShared9.0555.340110
4x65E2x52Shared4.573.920021
E2.E182E2.T180npy1_off5.64500112
E2.P183E2.V197Shared6.1855.30112
E2.F184E2x51npy1_off4.82500111
E2.D190E2.K193npy1_off4.8400112
E2.V197E2x51Shared7.8653.930121
E2.Q201E2x51Shared4.13.510021
E2.F202E2x52Shared5.3758.361121
E2x52LigShared4.8558.050110
5x36E2.F202Shared8.5519.241112
5x39E2.F202npy1_off5.67500022
5x335x36npy1_off8.3401111
5x33E3.H290npy1_off10.71501112
5x366x59Shared4.174.761111
5x36E3.H290npy1_off12.97501112
5x376x60Shared13.677.970022
5x395x43npy1_off11.1400021
5x406x59Shared12.28513.011111
5x40LigShared7.3059.061110
5x476x52Shared7.4918.730821
6x516x55Shared6.8658.240021
6x52Lignpy1_off10.13500010
6x546x58npy1_off12.32501111
6x547x33Shared6.72.441112
6x547x34Shared9.64512.861111
6x54LigShared9.3757.481110
6x55LigShared24.0920.350110
6x58E3.I292npy1_off4.39501011
6x587x30npy1_off9.61501011
6x58LigShared7.98524.111010
6x59LigShared13.788.341110
7x277x29npy1_off4.38500012
7x277x30npy1_off12.3200011
7x347x38npy1_off4.52501111
7x34LigShared13.02520.271110
7x387x42npy1_off12.47500112
7x27NT.N30npy1_off4.38500012
7x28NT.N30npy1_off4.72500112
3x365x461npy1_off4.11500111
E2.E182E2.Q185npy1_off7.0100112
E2.K193E2.K195npy1_off9.3400722
2x563x32Shared3.8157.630021
NT.D32NT.H34npy1_off3.7800112
E2.F184NT.F28npy1_off3.7500111
2x67E2.V187npy1_off3.6500011
E2.P183E2.T180npy1_off3.49500112
2x67E2.K195npy1_off3.45500012
E2.E182NT.N22npy1_off3.28500112
E2.V187NT.F28npy1_off3.27500011
NT.C33NT.D31npy1_off3.1100022
E2.F184E2.L189npy1_off3.04500112
6x61E3.I292npy1_off2.83500021
E3.A294Lignpy1_off2.60500010
5x365x37npy1_off2.42501112
E2.A191E2.D190npy1_off2.31500021
4x565x461npy1_off2.16500021
6x56Lignpy1_off2.0200010
NT.D31NT.D32npy1_off1.99500021
5x33NT.Q24npy1_off1.9601112
E2.D190E2.Y192npy1_off1.72500111
E2.V187NT.E29npy1_off1.42500011
6x576x58npy1_off1.3100021
E2.D190NT.F28npy1_on07.170111
LigNT.F28npy1_on09.281101
E2.Y192NT.E29npy1_on08.980111
LigNT.E29npy1_on032.541101
NT.D31NT.N30npy1_on09.420022
NT.D32NT.L35npy1_on010.860112
LigNT.D32npy1_on09.531101
2x532x56npy1_on06.830022
2x533x36npy1_on04.610021
2x5512x59npy1_on07.460122
2x5513x28npy1_on08.410121
2x5513x32npy1_on04.080121
2x577x38npy1_on03.860121
2x593x28npy1_on015.710121
2x603x32npy1_on04.250111
2x60Lignpy1_on016.150110
2x63Lignpy1_on022.270110
2x67Lignpy1_on013.680010
3x28E1x50npy1_on04.520112
3x283x32npy1_on013.20111
3x28Lignpy1_on03.960110
3x33Lignpy1_on05.470110
E2.E182E2.P183npy1_on07.860111
E2.E182Lignpy1_on08.10110
E2.P183E2x51npy1_on04.330111
E2.P183Lignpy1_on04.170110
E2.F184E2.K195npy1_on04.960112
E2.F184E2.V197npy1_on011.80112
E2.F184Lignpy1_on010.090110
E2.L189E2.Q185npy1_on014.640722
E2.K193E2.Q185npy1_on09.490722
E2.N186E2.T188npy1_on010.240111
E2.N186Lignpy1_on013.710110
E2.V187Lignpy1_on04.430010
E2.T188Lignpy1_on020.650110
E2.K193E2.L189npy1_on07.050722
E2.D190Lignpy1_on09.20110
E2.K195E2.Y192npy1_on05.970021
E2.Y192Lignpy1_on04.760110
E2x51Lignpy1_on011.210110
5x36E2x52npy1_on013.11111
5x336x61npy1_on013.461112
5x36Lignpy1_on012.351110
5x435x46npy1_on04.150112
5x435x461npy1_on06.650111
5x43Lignpy1_on04.680110
5x445x47npy1_on03.520822
5x446x56npy1_on05.90821
5x461Lignpy1_on015.750110
6x547x30npy1_on05.661111
6x566x60npy1_on04.850012
6x57E3.H290npy1_on08.30022
6x60E3.H290npy1_on04.230022
E3.I292Lignpy1_on06.240010
7x27Lignpy1_on010.950010
7x28Lignpy1_on08.850110
7x30Lignpy1_on013.810110
7x31Lignpy1_on09.540010
7x38Lignpy1_on07.610110
7x30E3.A294npy1_on02.930111
3x373x41npy1_on02.590022
NT.F28NT.N30npy1_on02.420112
4x564x57npy1_on01.630022
E2.A191E2.Y192npy1_on01.330021
5x33Lignpy1_on01.151110

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
npy1_off 5ZBH-Y1-BMS-193885
5ZBQ-Y1-UR-MK-299
npy1_on 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
Network Difference
Value npy1_off npy1_on
Imin 4.055 3.52
Number of Linked Nodes 302 288
Number of Specific Nodes 23 (7.62%) 9  (3.13%)
Number of Shared Nodes 279 (92.38%) 279  (96.88%)
Number of Links 314 320
Number of Specific Links 162 (51.59%) 168  (52.50%)
Number of Shared Links 152 (48.41%) 152  (47.50%)
Number of Hubs 30 36
Number of Specific Hubs 12 (40.00%) 18  (50.00%)
Number of Shared Hubs 18 (60.00%) 18  (50.00%)
Average % Shared Neighbours (Jaccard) 35.35
Average % Shared Neighbours (Otsuka) 43.68
Average % Shared Neighbours (Overlap Coefficient) 51.84
Average % Shared Cliques (k3-6) 76.97
Graphlets Similarity 0.485178
Paths Difference
Value npy1_off npy1_on
Number Of Nodes in MetaPath 91 38
Specific Nodes in MetaPath 73 (80.22%) 20  (52.63%)
Shared Nodes in MetaPath 279 (92.38%) 279  (92.38%)
Number Of Links MetaPath 95 39
Specific Links in MetaPath 90 (94.74%) 34  (87.18%)
Shared Links in MetaPath 152 (48.41%) 152  (48.41%)
Number of Shortest Paths 50010 57143
Length Of Smallest Path 3 3
Average Path Length 15.0685 13.4174
Length of Longest Path 39 28
Minimum Path Strength 0.77 1.12
Average Path Strength 6.62589 6.84853
Maximum Path Strength 18.935 28.325
Minimum Path Correlation 0.7 0.7
Average Path Correlation 0.930356 0.940375
Maximum Path Correlation 0.99 0.99
Minimum % Of Corr. Nodes 2.77778 5.55556
Average % Of Corr. Nodes 52.4243 59.4621
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 33.4083 41.7015
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download npy1_off_on.zip<



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.