psnGPCR

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Orange: nodes, hubs and links specific of ox2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ox2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ox2_off Int. Strength	ox2_on Int. Strength	ox2_off Hub1?	ox2_on Hub1?	ox2_off Hub2?	ox2_on Hub2?	ConSurf1	ConSurf2
1	NT.D33	NT.D35	ox2_off	100	0	No	No	No	No	7	4
2	NT.E37	NT.Y34	ox2_off	100	0	No	No	No	No	4	9
3	NT.E37	NT.L40	ox2_off	100	0	No	No	No	No	4	4
4	NT.E38	NT.R41	ox2_off	100	0	Yes	No	No	No	6	5
5	E1x49	NT.E38	ox2_off	100	0	Yes	No	Yes	No	5	6
6	E1x51	NT.E38	ox2_off	100	0	No	No	Yes	No	4	6
7	E2.T208	NT.E38	ox2_off	100	0	No	No	Yes	No	3	6
8	NT.F39	NT.L43	ox2_off	100	0	No	No	No	No	5	8
9	NT.R45	NT.Y42	ox2_off	100	0	Yes	No	Yes	No	6	4
10	NT.E46	NT.Y42	ox2_off	100	0	No	No	Yes	No	7	4
11	2x66	NT.Y42	ox2_off	100	0	Yes	No	Yes	No	5	4
12	E1x49	NT.R45	ox2_off	100	0	Yes	No	Yes	No	5	6
13	E2.T205	NT.R45	ox2_off	100	0	No	No	Yes	No	3	6
14	E2.F207	NT.R45	ox2_off	100	0	Yes	Yes	Yes	No	3	6
15	NT.L48	NT.Y47	ox2_off	100	0	No	No	No	No	4	5
16	7x27	NT.H49	ox2_off	100	0	No	Yes	No	No	1	4
17	1x31	NT.K51	ox2_off	100	0	Yes	No	Yes	No	4	4
18	2x67	NT.K51	ox2_off	100	0	No	No	Yes	No	4	4
19	1x35	1x39	ox2_off	100	0	No	No	Yes	Yes	5	7
20	1x35	2x65	ox2_off	100	0	No	No	No	No	5	5
21	1x39	2x60	ox2_off	100	0	Yes	Yes	Yes	No	7	7
22	1x43	2x54	ox2_off	100	0	No	Yes	No	No	6	7
23	1x49	7x50	ox2_off	100	0	No	No	No	No	8	9
24	1x53	7x50	ox2_off	100	0	No	No	No	No	9	9
25	1x53	8x50	ox2_off	100	0	No	No	Yes	Yes	9	8
26	1x54	1x58	ox2_off	100	0	No	No	No	No	6	3
27	1x55	1x59	ox2_off	100	0	No	No	No	No	5	6
28	1x56	8x53	ox2_off	100	0	No	No	Yes	Yes	8	7
29	1x58	2x44	ox2_off	100	0	No	No	No	No	3	6
30	8x49	I1x50	ox2_off	100	0	No	No	Yes	Yes	7	8
31	2x38	3x49	ox2_off	100	0	No	No	No	No	6	9
32	2x38	4x42	ox2_off	100	0	No	No	No	No	6	7
33	2x39	3x50	ox2_off	100	0	No	No	No	No	8	9
34	2x39	6x37	ox2_off	100	0	No	No	Yes	No	8	8
35	2x40	8x50	ox2_off	100	0	No	No	Yes	Yes	9	8
36	2x42	3x42	ox2_off	100	0	Yes	Yes	No	No	8	7
37	2x43	7x53	ox2_off	100	0	No	No	Yes	Yes	8	9
38	2x46	3x39	ox2_off	100	0	No	Yes	No	No	9	9
39	2x49	3x35	ox2_off	100	0	No	No	No	No	8	5
40	2x52	2x551	ox2_off	100	0	No	No	Yes	No	6	5
41	2x53	2x56	ox2_off	100	0	No	No	No	No	7	7
42	2x551	2x56	ox2_off	100	0	Yes	No	No	No	5	7
43	2x551	3x31	ox2_off	100	0	Yes	No	No	No	5	5
44	2x59	E1x52	ox2_off	100	0	No	No	No	No	4	6
45	2x60	2x64	ox2_off	100	0	Yes	No	No	No	7	5
46	2x62	E1x52	ox2_off	100	0	No	No	No	No	4	6
47	2x66	E1x51	ox2_off	100	0	Yes	No	No	No	5	4
48	3x28	E1x50	ox2_off	100	0	No	No	Yes	Yes	5	7
49	3x22	3x26	ox2_off	100	0	No	No	No	No	4	6
50	3x22	E2.C193	ox2_off	100	0	No	No	No	No	4	4
51	3x32	7x42	ox2_off	100	0	No	Yes	Yes	Yes	7	7
52	3x33	5x43	ox2_off	100	0	Yes	No	Yes	No	6	5
53	3x36	6x48	ox2_off	100	0	No	No	Yes	Yes	6	7
54	3x38	4x53	ox2_off	100	0	No	No	No	No	7	8
55	3x44	5x54	ox2_off	100	0	No	No	No	No	7	8
56	3x46	6x37	ox2_off	100	0	No	No	Yes	No	8	8
57	3x49	3x50	ox2_off	100	0	No	No	No	No	9	9
58	3x50	3x53	ox2_off	100	0	No	No	No	No	9	8
59	3x52	3x56	ox2_off	100	0	Yes	Yes	Yes	No	4	6
60	3x52	I2x53	ox2_off	100	0	Yes	Yes	No	No	4	7
61	3x54	5x64	ox2_off	100	0	No	No	No	No	8	5
62	3x54	5x65	ox2_off	100	0	No	No	No	Yes	8	8
63	3x54	6x30	ox2_off	100	0	No	No	No	No	8	8
64	3x55	5x60	ox2_off	100	0	No	No	No	No	7	5
65	3x56	I2x51	ox2_off	100	0	Yes	No	No	No	6	7
66	3x56	I2x53	ox2_off	100	0	Yes	No	No	No	6	7
67	I2x51	I2x53	ox2_off	100	0	No	No	No	No	7	7
68	4x61	E2x52	ox2_off	100	0	Yes	No	Yes	Yes	6	4
69	4x61	Lig	ox2_off	100	0	Yes	No	Yes	Yes	6	0
70	E2.R213	E2.S194	ox2_off	100	0	No	No	No	No	4	3
71	E2.R213	E2x51	ox2_off	100	0	No	No	No	No	4	5
72	5x34	5x38	ox2_off	100	0	No	No	No	No	4	4
73	5x58	6x38	ox2_off	100	0	Yes	Yes	No	No	9	6
74	5x63	5x67	ox2_off	100	0	No	No	No	No	4	5
75	5x63	5x68	ox2_off	100	0	No	No	No	No	4	7
76	5x65	5x66	ox2_off	100	0	No	Yes	Yes	No	8	5
77	5x69	6x27	ox2_off	100	0	No	No	No	No	5	4
78	6x28	6x32	ox2_off	100	0	No	No	No	No	5	8
79	6x35	7x56	ox2_off	100	0	No	No	No	No	8	7
80	6x36	7x53	ox2_off	100	0	No	No	Yes	Yes	8	9
81	6x39	7x52	ox2_off	100	0	No	No	No	No	6	8
82	6x39	7x56	ox2_off	100	0	No	No	No	No	6	7
83	6x40	7x49	ox2_off	100	0	No	No	No	Yes	8	9
84	6x42	6x46	ox2_off	100	0	No	No	No	No	4	5
85	6x44	7x45	ox2_off	100	0	Yes	Yes	Yes	No	9	9
86	6x47	7x40	ox2_off	100	0	No	No	No	No	8	8
87	6x57	E3.M332	ox2_off	100	0	No	No	No	No	5	3
88	7x34	7x38	ox2_off	100	0	Yes	Yes	Yes	Yes	4	5
89	7x39	7x40	ox2_off	100	0	Yes	Yes	No	No	5	8
90	7x53	8x50	ox2_off	100	0	Yes	Yes	Yes	Yes	9	8
91	7x54	7x55	ox2_off	100	0	No	No	No	No	7	5
92	7x54	8x51	ox2_off	100	0	No	No	No	No	7	8
93	7x54	8x54	ox2_off	100	0	No	No	No	Yes	7	7
94	8x50	8x54	ox2_off	100	0	Yes	Yes	No	Yes	8	7
95	8x59	CT.H387	ox2_off	100	0	No	No	No	No	4	5
96	8x60	CT.H388	ox2_off	100	0	No	No	No	No	9	4
97	8x61	8x62	ox2_off	100	0	No	No	No	No	3	1
98	NT.L48	NT.W44	ox2_off	100	0	No	No	No	No	4	7
99	NT.E46	NT.K51	ox2_off	100	0	No	No	Yes	No	7	4
100	1x32	NT.E46	ox2_off	100	0	No	No	No	No	7	7
101	2x41	I1x51	ox2_off	100	0	No	No	No	No	4	8
102	3x41	5x50	ox2_off	100	0	No	No	No	No	6	9
103	5x40	6x55	ox2_off	100	0	No	No	No	No	6	7
104	5x64	5x68	ox2_off	100	0	No	No	No	No	5	7
105	5x71	6x23	ox2_off	100	0	Yes	No	No	No	0	0
106	6x20	6x23	ox2_off	100	0	No	No	No	No	0	0
107	E2.F207	E2.V209	ox2_off	50	0	Yes	Yes	No	No	3	5
108	7x34	E3.F333	ox2_off	50	0	Yes	Yes	No	No	4	4
109	NT.H49	NT.L48	ox2_off	50	0	No	No	No	No	4	4
110	6x30	I2x52	ox2_off	50	0	No	No	No	No	8	5
111	NT.F39	NT.Y42	ox2_off	0	0	No	No	Yes	No	5	4
112	2x51	2x55	ox2_off	0	0	No	No	No	No	7	4
113	1x52	8x58	ox2_off	50	0	Yes	No	No	No	6	5
114	2x55	2x551	ox2_off	0	0	No	No	Yes	No	4	5
115	5x51	5x55	ox2_off	0	0	No	No	No	No	6	5
116	6x33	6x37	ox2_off	0	0	No	No	Yes	No	8	8
117	1x36	1x40	ox2_off	0	0	No	No	No	No	5	3
118	1x36	2x65	ox2_off	0	0	No	No	No	No	5	5
119	6x53	6x57	ox2_off	0	0	No	No	No	No	5	5
120	4x39	4x43	ox2_off	50	0	No	No	No	No	3	4
121	8x58	8x62	ox2_off	50	0	No	No	No	No	5	1
122	4x41	I2.S164	ox2_off	50	0	No	No	No	No	7	5
123	1x57	8x50	ox2_off	0	0	No	No	Yes	Yes	7	8
124	NT.D36	NT.E37	ox2_off	50	0	No	No	No	No	5	4
125	5x66	6x34	ox2_off	0	0	Yes	No	No	No	5	7
126	1x42	7x47	ox2_off	0	0	No	No	No	No	7	5
127	1x31	1x34	ox2_off	50	0	Yes	No	No	No	4	6
128	5x66	6x35	ox2_off	0	0	Yes	No	No	No	5	8
129	NT.T32	NT.Y34	ox2_off	50	0	No	No	No	No	5	9
130	8x51	8x55	ox2_off	50	0	No	No	No	No	8	5
131	3x47	5x57	ox2_off	0	0	No	No	No	No	8	5
132	3x55	5x61	ox2_off	50	0	No	No	No	No	7	9
133	2x63	E1x50	ox2_off	0	0	No	No	Yes	Yes	5	7
134	1x44	1x48	ox2_off	0	0	No	No	No	No	4	4
135	8x63	CT.V386	ox2_off	50	0	No	No	No	No	4	3
136	4x59	4x63	ox2_off	0	0	No	No	No	No	5	5
137	E2.A206	E2.F197	ox2_off	50	0	No	No	No	No	4	2
138	CT.H387	CT.V386	ox2_off	50	0	No	No	No	No	5	3
139	7x33	7x36	ox2_off	0	0	No	No	No	No	5	4
140	5x70	6x31	ox2_off	50	0	No	No	No	No	0	5
141	3x41	5x46	ox2_off	50	0	No	No	No	No	6	4
142	E2.P198	E2.V196	ox2_off	0	0	No	No	No	No	2	3
143	5x70	5x71	ox2_off	50	0	No	No	Yes	No	0	0
144	5x71	6x24	ox2_off	50	0	Yes	No	No	No	0	0
145	5x71	6x27	ox2_off	50	0	Yes	No	No	No	0	4
146	1x31	NT.E52	ox2_off	50	0	Yes	No	No	No	4	3
147	1x51	1x55	ox2_off	0	0	No	No	No	No	4	5
148	1x52	8x57	ox2_off	0	0	Yes	No	No	No	6	6
149	E2.K203	E2.T204	ox2_off	0	0	No	Yes	No	No	3	3
150	7x26	E3.E337	ox2_off	0	0	No	No	No	No	3	2
151	E2.F197	E2.T195	ox2_off	0	0	No	No	No	No	2	2
152	4x38	4x41	ox2_off	0	0	No	No	No	No	5	7
153	1x31	7x28	ox2_off	0	0	Yes	No	No	No	4	1
154	5x71	5x72	ox2_off	0	0	Yes	No	No	No	0	0
155	8x63	CT.G385	ox2_off	0	0	No	No	No	No	4	1
156	6x43	7x48	ox2_off	0	0	No	No	No	No	6	6
157	6x20	6x22	ox2_off	0	0	No	No	No	No	0	0
158	6x21	6x25	ox2_off	0	0	No	No	No	No	0	3
159	7x30	E3.T336	ox2_off	0	0	No	No	No	No	5	4
160	1x41	1x45	ox2_off	0	0	No	No	No	No	3	5
161	7x28	7x32	ox2_off	0	0	No	No	No	No	1	1
162	8x53	8x56	ox2_off	0	0	Yes	Yes	No	No	7	4
163	8x56	CT.H387	ox2_off	0	0	No	No	No	No	4	5
164	8x60	CT.G385	ox2_off	0	0	No	No	No	No	9	1
165	NT.L40	NT.L43	ox2_off	0	0	No	No	No	No	4	8
166	NT.D33	NT.D36	ox2_off	0	0	No	No	No	No	7	5
167	E2.L206	NT.R41	ox2_off	0	0	No	No	No	No	0	5
168	1x33	1x34	Shared	100	100	No	Yes	No	No	4	6
169	1x39	2x57	Shared	100	100	Yes	Yes	Yes	Yes	7	7
170	1x39	2x61	Shared	100	100	Yes	Yes	No	No	7	6
171	1x39	7x39	Shared	100	100	Yes	Yes	Yes	Yes	7	5
172	1x39	7x42	Shared	100	100	Yes	Yes	Yes	Yes	7	7
173	1x42	7x39	Shared	100	100	No	No	Yes	Yes	7	5
174	1x43	2x57	Shared	100	100	No	Yes	Yes	Yes	6	7
175	1x45	7x47	Shared	100	0	No	No	No	No	5	5
176	1x46	2x54	Shared	100	100	No	No	No	No	8	7
177	1x50	2x47	Shared	100	100	No	Yes	No	No	9	9
178	1x50	2x50	Shared	100	100	No	Yes	No	Yes	9	9
179	1x50	7x50	Shared	100	100	No	Yes	No	No	9	9
180	1x52	8x54	Shared	100	100	Yes	No	No	Yes	6	7
181	1x53	2x47	Shared	100	100	No	No	No	No	9	9
182	1x57	2x44	Shared	100	100	No	No	No	No	7	6
183	1x58	I1x51	Shared	100	0	No	No	No	No	3	8
184	1x60	I1x49	Shared	100	100	No	Yes	No	No	6	5
185	1x60	I1x50	Shared	100	100	No	Yes	Yes	Yes	6	8
186	1x60	8x53	Shared	100	100	No	Yes	Yes	Yes	6	7
187	I1x48	I1x51	Shared	100	100	No	No	No	No	7	8
188	8x50	I1x50	Shared	100	100	Yes	Yes	Yes	Yes	8	8
189	8x53	I1x50	Shared	100	100	Yes	Yes	Yes	Yes	7	8
190	2x37	2x40	Shared	100	100	No	No	No	No	7	9
191	2x38	I2.S164	Shared	100	66.6667	No	No	No	No	6	5
192	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	6
193	2x42	3x46	Shared	100	100	Yes	Yes	No	No	8	8
194	2x42	4x45	Shared	100	100	Yes	Yes	No	No	8	6
195	2x42	4x46	Shared	100	100	Yes	Yes	No	No	8	8
196	2x45	3x42	Shared	100	100	No	No	No	No	9	7
197	2x45	4x46	Shared	100	100	No	No	No	No	9	8
198	2x45	4x50	Shared	100	100	No	No	No	No	9	9
199	2x46	3x43	Shared	100	100	No	Yes	No	No	9	9
200	2x50	7x46	Shared	100	100	No	Yes	No	No	9	9
201	2x53	3x35	Shared	100	33.3333	No	No	No	No	7	5
202	2x56	3x32	Shared	100	100	No	No	No	Yes	7	7
203	2x57	2x58	Shared	100	66.6667	Yes	Yes	No	No	7	8
204	2x57	7x42	Shared	100	100	Yes	Yes	Yes	Yes	7	7
205	2x60	7x38	Shared	100	100	Yes	No	Yes	Yes	7	5
206	2x60	7x42	Shared	100	100	Yes	No	Yes	Yes	7	7
207	2x60	Lig	Shared	100	100	Yes	No	Yes	Yes	7	0
208	2x62	2x66	Shared	100	33.3333	No	No	Yes	No	4	5
209	2x64	7x35	Shared	100	100	No	No	No	No	5	4
210	2x64	7x38	Shared	100	100	No	No	Yes	Yes	5	5
211	2x66	E1x49	Shared	100	100	Yes	No	Yes	No	5	5
212	2x67	7x27	Shared	100	100	No	No	No	Yes	4	1
213	E1x49	E1x51	Shared	100	100	Yes	No	No	No	5	4
214	E1x49	E2.F207	Shared	100	100	Yes	No	Yes	Yes	5	3
215	E1x50	E1x52	Shared	100	100	Yes	Yes	No	No	7	6
216	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	7
217	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	7	9
218	3x22	E2.E192	Shared	100	100	No	No	No	No	4	5
219	3x24	3x28	Shared	100	100	No	Yes	No	No	5	5
220	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
221	3x26	E2.E192	Shared	100	33.3333	No	No	No	No	6	5
222	3x28	3x29	Shared	100	100	No	No	No	No	5	5
223	3x29	4x65	Shared	100	100	No	No	No	No	5	6
224	3x29	Lig	Shared	100	100	No	No	Yes	Yes	5	0
225	3x30	3x34	Shared	100	100	No	No	No	No	6	5
226	3x30	4x62	Shared	100	100	No	No	No	No	6	6
227	3x32	Lig	Shared	100	100	No	Yes	Yes	Yes	7	0
228	3x33	4x57	Shared	100	100	Yes	No	Yes	Yes	6	7
229	3x33	4x61	Shared	100	100	Yes	No	Yes	No	6	6
230	3x33	Lig	Shared	100	100	Yes	No	Yes	Yes	6	0
231	3x34	4x57	Shared	100	100	No	No	Yes	Yes	5	7
232	3x36	Lig	Shared	100	100	No	No	Yes	Yes	6	0
233	3x37	4x53	Shared	100	100	No	No	No	No	7	8
234	3x38	4x49	Shared	100	100	No	No	No	No	7	6
235	3x38	4x50	Shared	100	100	No	No	No	No	7	9
236	3x40	5x50	Shared	100	100	No	No	No	No	8	9
237	3x41	4x49	Shared	100	100	No	No	No	No	6	6
238	3x43	6x44	Shared	100	100	No	No	Yes	Yes	9	9
239	3x47	5x58	Shared	100	100	No	No	Yes	Yes	8	9
240	3x48	3x52	Shared	100	33.3333	No	No	Yes	Yes	6	4
241	3x49	I2.S164	Shared	100	100	No	No	No	No	9	5
242	3x51	3x52	Shared	100	100	Yes	Yes	Yes	Yes	8	4
243	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	7
244	3x51	3x56	Shared	100	100	Yes	Yes	Yes	No	8	6
245	3x51	5x57	Shared	100	100	Yes	Yes	No	No	8	5
246	3x51	5x60	Shared	100	100	Yes	Yes	No	No	8	5
247	3x56	I2x50	Shared	100	0	Yes	No	No	No	6	9
248	4x56	4x57	Shared	100	66.6667	No	No	Yes	Yes	5	7
249	4x57	5x43	Shared	100	100	Yes	Yes	Yes	No	7	5
250	4x59	4x60	Shared	100	100	No	No	No	No	5	6
251	4x60	5x39	Shared	100	100	No	No	No	Yes	6	8
252	4x61	5x39	Shared	100	100	Yes	No	No	Yes	6	8
253	4x64	E2x52	Shared	100	100	No	No	Yes	Yes	6	4
254	4x64	E2.W214	Shared	100	100	No	No	Yes	Yes	6	4
255	E2.E192	E2.R213	Shared	100	100	No	No	No	No	5	4
256	E2.T195	E2.T208	Shared	100	100	No	No	No	No	2	3
257	E2.F207	E2.V196	Shared	100	100	Yes	Yes	No	No	3	3
258	6x59	E2x51	Shared	100	100	Yes	Yes	No	No	4	5
259	E2.W214	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	4	4
260	5x40	E2x52	Shared	100	100	No	No	Yes	Yes	6	4
261	6x59	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	4	4
262	5x36	E2.W214	Shared	100	100	No	No	Yes	Yes	5	4
263	5x39	E2.W214	Shared	100	100	No	Yes	Yes	Yes	8	4
264	5x40	6x59	Shared	100	100	No	No	Yes	Yes	6	4
265	5x41	6x60	Shared	100	0	No	No	No	Yes	5	5
266	5x43	5x461	Shared	100	100	Yes	No	No	No	5	6
267	5x43	Lig	Shared	100	100	Yes	No	Yes	Yes	5	0
268	5x44	5x47	Shared	100	100	Yes	Yes	Yes	Yes	6	8
269	5x44	5x48	Shared	100	0	Yes	Yes	No	No	6	5
270	5x44	6x52	Shared	100	100	Yes	Yes	No	No	6	6
271	5x44	6x56	Shared	100	100	Yes	Yes	No	No	6	6
272	5x47	5x51	Shared	100	100	Yes	Yes	No	No	8	6
273	5x47	6x49	Shared	100	100	Yes	Yes	No	No	8	6
274	5x47	6x52	Shared	100	100	Yes	Yes	No	No	8	6
275	5x54	6x41	Shared	100	100	No	No	No	Yes	8	8
276	5x58	6x37	Shared	100	100	Yes	Yes	Yes	No	9	8
277	5x58	6x41	Shared	100	100	Yes	Yes	No	Yes	9	8
278	5x62	5x66	Shared	100	100	No	No	Yes	No	6	5
279	5x66	6x31	Shared	100	100	Yes	No	No	No	5	5
280	6x27	6x31	Shared	100	100	No	No	No	No	4	5
281	6x32	6x35	Shared	100	100	No	No	No	No	8	8
282	6x36	7x56	Shared	100	100	No	No	No	No	8	7
283	6x40	7x52	Shared	100	100	No	No	No	No	8	8
284	6x43	7x52	Shared	100	0	No	No	No	No	6	8
285	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	7
286	6x47	7x45	Shared	100	100	No	No	Yes	No	8	9
287	6x48	7x41	Shared	100	100	Yes	Yes	No	No	7	7
288	6x48	7x45	Shared	100	100	Yes	Yes	Yes	No	7	9
289	6x51	7x37	Shared	100	100	No	Yes	No	No	7	6
290	6x51	Lig	Shared	100	100	No	Yes	Yes	Yes	7	0
291	6x54	7x34	Shared	100	100	No	No	Yes	Yes	5	4
292	6x55	Lig	Shared	100	100	No	No	Yes	Yes	7	0
293	6x58	6x59	Shared	100	100	No	No	Yes	Yes	3	4
294	6x58	7x34	Shared	100	100	No	No	Yes	Yes	3	4
295	E3.F333	E3.M332	Shared	100	100	No	No	No	No	4	3
296	7x30	E3.F333	Shared	100	100	No	No	No	No	5	4
297	7x26	7x29	Shared	100	100	No	No	No	No	3	4
298	7x27	7x31	Shared	100	100	No	Yes	No	No	1	3
299	7x36	7x40	Shared	100	100	No	No	No	No	4	8
300	7x38	Lig	Shared	100	100	Yes	Yes	Yes	Yes	5	0
301	7x39	7x43	Shared	100	100	Yes	Yes	No	No	5	4
302	7x45	7x49	Shared	100	100	Yes	No	No	Yes	9	9
303	7x49	7x53	Shared	100	100	No	Yes	Yes	Yes	9	9
304	8x47	8x50	Shared	100	33.3333	No	No	Yes	Yes	8	8
305	8x48	8x51	Shared	100	100	No	No	No	No	5	8
306	8x52	8x55	Shared	100	33.3333	No	No	No	No	5	5
307	1x32	NT.K51	Shared	100	33.3333	No	No	Yes	No	7	4
308	5x59	5x63	Shared	100	0	No	No	No	No	2	4
309	6x26	6x30	Shared	100	100	No	No	No	No	4	8
310	3x30	4x54	Shared	50	0	No	No	No	No	6	4
311	3x40	6x44	Shared	50	100	No	No	Yes	Yes	8	9
312	6x60	6x61	Shared	50	100	No	Yes	No	No	5	3
313	1x54	2x48	Shared	50	0	No	No	No	No	6	5
314	5x51	6x45	Shared	0	0	No	No	No	No	6	5
315	7x51	7x55	Shared	50	33.3333	No	No	No	No	6	5
316	4x47	4x51	Shared	0	0	No	No	No	No	3	3
317	3x27	3x31	Shared	0	33.3333	No	No	No	No	4	5
318	1x47	2x55	Shared	0	33.3333	No	No	No	No	6	4
319	1x48	1x52	Shared	0	33.3333	No	No	Yes	No	4	6
320	3x21	E1x50	Shared	0	0	No	No	Yes	Yes	8	7
321	6x50	7x37	Shared	50	100	No	No	No	No	9	6
322	6x49	6x50	Shared	50	100	No	No	No	No	6	9
323	7x29	7x33	Shared	0	0	No	No	No	No	4	5
324	6x56	6x60	Shared	50	0	No	No	No	Yes	6	5
325	4x52	4x56	Shared	0	0	No	No	No	No	5	5
326	5x35	E2.W214	Shared	0	0	No	No	Yes	Yes	3	4
327	4x51	4x55	Shared	0	0	No	No	No	No	3	3
328	5x45	5x48	Shared	0	0	No	No	No	No	4	5
329	E2.G215	E2.G216	Shared	0	0	No	No	No	No	4	5
330	1x37	1x38	Shared	0	0	No	No	No	No	4	4
331	5x49	5x50	Shared	0	0	No	No	No	No	5	9
332	5x48	5x52	Shared	50	100	No	No	No	No	5	4
333	1x51	2x51	Shared	0	0	No	No	No	No	4	7
334	2x41	4x43	Shared	0	33.3333	No	No	No	No	4	4
335	4x48	4x52	Shared	0	0	No	No	No	No	3	5
336	NT.H49	NT.P50	Shared	0	0	No	No	No	No	4	5
337	3x44	5x53	Shared	0	33.3333	No	No	No	No	7	7
338	4x38	4x40	Shared	0	100	No	No	No	No	5	5
339	1x38	7x39	Shared	0	0	No	No	Yes	Yes	4	5
340	E2.G215	E2.W214	Shared	0	0	No	No	Yes	Yes	4	4
341	4x40	4x44	Shared	0	100	No	No	No	No	5	3
342	E3.A334	E3.H335	Shared	0	33.3333	No	No	No	No	2	1
343	5x34	5x35	Shared	0	33.3333	No	No	No	No	4	3
344	1x35	7x35	ox2_on	0	100	No	No	No	No	5	4
345	1x39	7x35	ox2_on	0	100	Yes	Yes	No	No	7	4
346	1x43	1x47	ox2_on	0	100	No	Yes	No	No	6	6
347	1x50	2x51	ox2_on	0	100	No	Yes	No	No	9	7
348	1x53	7x54	ox2_on	0	100	No	No	No	No	9	7
349	1x56	8x54	ox2_on	0	100	No	No	No	Yes	8	7
350	1x58	1x59	ox2_on	0	100	No	No	No	No	3	6
351	1x60	8x57	ox2_on	0	100	No	Yes	No	No	6	6
352	2x37	2x39	ox2_on	0	100	No	No	No	No	7	8
353	2x43	7x54	ox2_on	0	100	No	No	No	No	8	7
354	2x46	2x50	ox2_on	0	100	No	Yes	No	Yes	9	9
355	2x46	3x42	ox2_on	0	100	No	Yes	No	No	9	7
356	2x46	7x49	ox2_on	0	100	No	Yes	No	Yes	9	9
357	2x50	7x49	ox2_on	0	100	No	Yes	No	Yes	9	9
358	2x52	3x35	ox2_on	0	100	No	No	No	No	6	5
359	2x53	7x46	ox2_on	0	100	No	No	No	No	7	9
360	2x56	7x42	ox2_on	0	100	No	No	Yes	Yes	7	7
361	2x63	Lig	ox2_on	0	100	No	No	Yes	Yes	5	0
362	2x67	7x31	ox2_on	0	100	No	No	No	No	4	3
363	E1x50	Lig	ox2_on	0	100	Yes	Yes	Yes	Yes	7	0
364	3x24	E1x52	ox2_on	0	100	No	Yes	No	No	5	6
365	3x28	3x32	ox2_on	0	100	No	No	No	Yes	5	7
366	3x37	4x57	ox2_on	0	100	No	No	Yes	Yes	7	7
367	3x40	6x48	ox2_on	0	100	No	No	Yes	Yes	8	7
368	3x43	7x53	ox2_on	0	100	No	No	Yes	Yes	9	9
369	3x45	4x49	ox2_on	0	100	No	No	No	No	6	6
370	3x46	3x50	ox2_on	0	100	No	No	No	No	8	9
371	3x46	7x53	ox2_on	0	100	No	No	Yes	Yes	8	9
372	3x50	5x58	ox2_on	0	100	No	No	Yes	Yes	9	9
373	3x50	7x53	ox2_on	0	100	No	No	Yes	Yes	9	9
374	3x52	I2.K163	ox2_on	0	100	Yes	Yes	No	No	4	5
375	3x52	4x41	ox2_on	0	100	Yes	Yes	No	No	4	7
376	3x54	5x61	ox2_on	0	100	No	No	No	No	8	9
377	3x56	I2x52	ox2_on	0	100	Yes	No	No	No	6	5
378	I2.K163	I2x52	ox2_on	0	100	No	No	No	No	5	5
379	4x41	I2.K163	ox2_on	0	100	No	No	No	No	7	5
380	4x43	4x44	ox2_on	0	100	No	No	No	No	4	3
381	4x63	4x64	ox2_on	0	100	No	No	No	No	5	6
382	4x65	E2x52	ox2_on	0	100	No	No	Yes	Yes	6	4
383	E2.F197	E2.L206	ox2_on	0	100	No	No	No	No	2	0
384	E2.K203	E2.P198	ox2_on	0	100	No	Yes	No	No	3	2
385	7x27	E2.K203	ox2_on	0	100	No	Yes	No	Yes	1	3
386	7x27	E2.F207	ox2_on	0	100	No	Yes	Yes	Yes	1	3
387	5x39	5x40	ox2_on	0	100	No	Yes	No	No	8	6
388	5x54	5x58	ox2_on	0	100	No	No	Yes	Yes	8	9
389	5x54	6x44	ox2_on	0	100	No	No	Yes	Yes	8	9
390	5x55	6x41	ox2_on	0	100	No	No	No	Yes	5	8
391	5x62	6x34	ox2_on	0	100	No	No	No	No	6	7
392	5x62	6x38	ox2_on	0	100	No	No	No	No	6	6
393	5x65	6x30	ox2_on	0	100	No	Yes	No	No	8	8
394	6x40	7x53	ox2_on	0	100	No	No	Yes	Yes	8	9
395	6x50	7x40	ox2_on	0	100	No	No	No	No	9	8
396	6x51	7x38	ox2_on	0	100	No	Yes	Yes	Yes	7	5
397	6x51	7x41	ox2_on	0	100	No	Yes	No	No	7	7
398	7x31	Lig	ox2_on	0	100	No	No	Yes	Yes	3	0
399	7x38	7x42	ox2_on	0	100	Yes	Yes	Yes	Yes	5	7
400	7x52	7x53	ox2_on	0	100	No	No	Yes	Yes	8	9
401	7x54	8x50	ox2_on	0	100	No	No	Yes	Yes	7	8
402	7x55	8x50	ox2_on	0	100	No	No	Yes	Yes	5	8
403	8x49	8x53	ox2_on	0	100	No	No	Yes	Yes	7	7
404	6x25	6x28	ox2_on	0	100	No	No	No	No	3	5
405	7x27	Lig	ox2_on	0	100	No	Yes	Yes	Yes	1	0
406	7x34	Lig	ox2_on	0	100	Yes	Yes	Yes	Yes	4	0
407	1x28	7x28	ox2_on	0	100	No	No	No	No	0	1
408	E2	E2.R213	ox2_on	0	100	No	No	No	No	0	4
409	8x54	8x58	ox2_on	0	100	No	Yes	No	No	7	5
410	5x37	6x60	ox2_on	0	33.3333	No	No	No	Yes	4	5
411	3x44	5x50	ox2_on	0	66.6667	No	No	No	No	7	9
412	2x50	3x39	ox2_on	0	66.6667	No	Yes	No	No	9	9
413	2x61	2x65	ox2_on	0	33.3333	No	No	No	No	6	5
414	2x40	2x43	ox2_on	0	33.3333	No	No	No	No	9	8
415	2x49	3x38	ox2_on	0	66.6667	No	No	No	No	8	7
416	2x42	4x42	ox2_on	0	0	Yes	Yes	No	No	8	7
417	I2x50	I2x51	ox2_on	0	66.6667	No	No	No	No	9	7
418	7x30	7x34	ox2_on	0	0	No	No	Yes	Yes	5	4
419	E2.F207	E2.T208	ox2_on	0	33.3333	Yes	Yes	No	No	3	3
420	7x27	E3.T336	ox2_on	0	33.3333	No	Yes	No	No	1	4
421	8x55	8x59	ox2_on	0	33.3333	No	No	No	No	5	4
422	5x65	6x33	ox2_on	0	33.3333	No	Yes	No	No	8	8
423	6x57	6x61	ox2_on	0	33.3333	No	No	No	No	5	3
424	1x29	1x31	ox2_on	0	33.3333	No	No	Yes	No	0	4
425	5x61	6x37	ox2_on	0	33.3333	No	No	Yes	No	9	8
426	5x61	5x65	ox2_on	0	33.3333	No	No	No	Yes	9	8
427	6x49	6x53	ox2_on	0	33.3333	No	No	No	No	6	5
428	6x38	6x41	ox2_on	0	0	No	No	No	Yes	6	8
429	1x48	1x49	ox2_on	0	33.3333	No	No	No	No	4	8
430	3x48	5x53	ox2_on	0	33.3333	No	No	No	No	6	7
431	1x54	2x47	ox2_on	0	33.3333	No	No	No	No	6	9
432	1x33	1x35	ox2_on	0	33.3333	No	Yes	No	No	4	5
433	2x38	4x39	ox2_on	0	33.3333	No	No	No	No	6	3
434	2x41	4x42	ox2_on	0	33.3333	No	No	No	No	4	7
435	7x55	8x54	ox2_on	0	33.3333	No	No	No	Yes	5	7
436	E2.V209	Lig	ox2_on	0	33.3333	No	No	Yes	Yes	5	0
437	1x57	I1x50	ox2_on	0	33.3333	No	No	Yes	Yes	7	8
438	E2.F197	E2.G199	ox2_on	0	33.3333	No	No	No	No	2	0
439	3x23	3x24	ox2_on	0	33.3333	No	No	No	Yes	3	5
440	1x47	2x54	ox2_on	0	0	No	No	No	No	6	7
441	6x32	6x36	ox2_on	0	33.3333	No	No	No	No	8	8
442	E2.L206	E2.T195	ox2_on	0	33.3333	No	No	No	No	0	2
443	2x551	3x32	ox2_on	0	33.3333	Yes	No	No	Yes	5	7
444	E2.K203	E2.L200	ox2_on	0	33.3333	No	Yes	No	No	3	0
445	5x64	5x65	ox2_on	0	33.3333	No	No	No	Yes	5	8
446	3x25	E2.C193	ox2_on	0	33.3333	No	No	No	No	9	4
447	1x33	NT.E52	ox2_on	0	33.3333	No	Yes	No	No	4	3
448	1x46	7x47	ox2_on	0	0	No	No	No	No	8	5
449	1x38	1x41	ox2_on	0	33.3333	No	No	No	No	4	3
450	7x26	7x28	ox2_on	0	33.3333	No	No	No	No	3	1
451	1x59	8x57	ox2_on	0	33.3333	No	No	No	No	6	6
452	2x42	3x49	ox2_on	0	0	Yes	Yes	No	No	8	9
453	E2.F207	E2.S194	ox2_on	0	33.3333	Yes	Yes	No	No	3	3
454	2x59	3x32	ox2_on	0	0	No	No	No	Yes	4	7
455	1x31	1x32	ox2_on	0	33.3333	Yes	No	No	No	4	7
456	3x24	3x27	ox2_on	0	0	No	Yes	No	No	5	4
457	7x26	E3.T336	ox2_on	0	33.3333	No	No	No	No	3	4
458	1x36	2x61	ox2_on	0	33.3333	No	No	No	No	5	6
459	7x51	7x56	ox2_on	0	0	No	No	No	No	6	7
460	1x32	1x35	ox2_on	0	33.3333	No	No	No	No	7	5
461	1x55	8x58	ox2_on	0	33.3333	No	No	No	No	5	5
462	1x43	1x44	ox2_on	0	0	No	Yes	No	No	6	4
463	6x24	6x28	ox2_on	0	33.3333	No	No	No	No	0	5
464	E2.E217	E2.G216	ox2_on	0	0	No	No	No	No	3	5
465	1x30	1x33	ox2_on	0	33.3333	No	No	No	Yes	0	4
466	1x60	8x56	ox2_on	0	0	No	Yes	No	No	6	4
467	6x36	6x39	ox2_on	0	33.3333	No	No	No	No	8	6
468	E2.K203	E2.T205	ox2_on	0	0	No	Yes	No	No	3	3
469	4x55	4x56	ox2_on	0	33.3333	No	No	No	No	3	5
470	3x26	4x63	ox2_on	0	33.3333	No	No	No	No	6	5
471	7x29	E3.D338	ox2_on	0	33.3333	No	No	No	No	4	0
472	5x59	6x38	ox2_on	0	0	No	No	No	No	2	6
473	8x52	8x53	ox2_on	0	0	No	No	Yes	Yes	5	7
474	1x40	1x43	ox2_on	0	0	No	No	No	Yes	3	6
475	E3.E337	E3.H335	ox2_on	0	0	No	No	No	No	2	1
476	6x28	6x31	ox2_on	0	0	No	No	No	No	5	5
477	6x25	6x29	ox2_on	0	0	No	No	No	No	3	6
478	5x42	5x45	ox2_on	0	0	No	No	No	No	4	4
479	5x46	5x461	ox2_on	0	0	No	No	No	No	4	6
480	E3.A334	Lig	ox2_on	0	0	No	No	Yes	Yes	2	0
481	4x47	4x48	ox2_on	0	0	No	No	No	No	3	3
482	5x38	5x41	ox2_on	0	0	No	No	No	No	4	5
483	6x23	6x27	ox2_on	0	0	No	No	No	No	0	4
484	6x23	6x24	ox2_on	0	0	No	No	No	No	0	0
485	5x56	5x60	ox2_on	0	0	No	No	No	No	4	5

Orange: nodes, hubs and links specific of ox2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ox2_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	ox2_off Avg Int. Strength	ox2_on Avg Int. Strength	ox2_off Num Of Links	ox2_on Num Of Links	ConSurf
1	NT.E38	ox2_off	50	0	4	0	6
2	NT.Y42	ox2_off	50	0	4	0	4
3	NT.R45	ox2_off	100	0	4	0	6
4	NT.K51	ox2_off	0	0	4	1	4
5	1x31	ox2_off	0	0	4	2	4
6	1x52	ox2_off	0	0	4	2	6
7	2x551	ox2_off	0	0	4	1	5
8	2x60	ox2_off	100	33.3333	5	3	7
9	2x66	ox2_off	100	0	4	2	5
10	E1x49	ox2_off	100	0	5	3	5
11	3x33	ox2_off	50	0	4	3	6
12	3x56	ox2_off	100	0	5	3	6
13	4x61	ox2_off	100	33.3333	4	2	6
14	5x43	ox2_off	100	0	4	3	5
15	5x66	ox2_off	0	0	5	2	5
16	6x37	ox2_off	0	0	4	2	8
17	7x45	ox2_off	50	33.3333	4	3	9
18	5x71	ox2_off	50	0	5	0	0
19	1x39	Shared	100	100	6	5	7
20	I1x50	Shared	100	33.3333	4	4	8
21	2x42	Shared	100	33.3333	5	6	8
22	2x57	Shared	100	33.3333	4	4	7
23	E1x50	Shared	100	100	6	5	7
24	3x51	Shared	100	100	5	5	8
25	3x52	Shared	50	0	4	4	4
26	4x57	Shared	50	33.3333	4	5	7
27	E2.F207	Shared	0	0	4	5	3
28	E2x52	Shared	100	100	5	5	4
29	E2.W214	Shared	100	66.6667	6	6	4
30	5x44	Shared	0	0	4	4	6
31	5x47	Shared	50	100	4	4	8
32	5x58	Shared	50	100	4	5	9
33	6x44	Shared	50	100	4	4	9
34	6x48	Shared	100	66.6667	4	4	7
35	6x59	Shared	100	66.6667	4	4	4
36	7x34	Shared	50	33.3333	4	4	4
37	7x38	Shared	50	66.6667	4	5	5
38	7x39	Shared	50	33.3333	5	4	5
39	7x42	Shared	100	100	4	5	7
40	7x53	Shared	50	100	4	6	9
41	8x50	Shared	100	0	7	4	8
42	8x53	Shared	0	0	4	4	7
43	Lig	Shared	100	100	10	16	0
44	1x33	ox2_on	0	0	1	4	4
45	1x43	ox2_on	0	0	2	4	6
46	1x50	ox2_on	0	0	3	4	9
47	1x60	ox2_on	0	33.3333	3	5	6
48	2x46	ox2_on	0	66.6667	2	4	9
49	2x50	ox2_on	0	100	2	5	9
50	3x24	ox2_on	0	0	1	4	5
51	3x32	ox2_on	0	33.3333	3	5	7
52	E2.K203	ox2_on	0	0	1	4	3
53	5x39	ox2_on	50	33.3333	3	4	8
54	5x65	ox2_on	0	33.3333	2	4	8
55	6x41	ox2_on	0	0	2	4	8
56	6x51	ox2_on	0	33.3333	2	4	7
57	6x60	ox2_on	0	0	3	4	5
58	7x27	ox2_on	0	33.3333	3	6	1
59	7x49	ox2_on	0	33.3333	3	4	9
60	8x54	ox2_on	50	0	3	4	7

Orange: nodes, hubs and links specific of ox2_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of ox2_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	ox2_off Recurrence	ox2_on Recurrence	ox2_off Hub1?	ox2_on Hub1?	ox2_off Hub2?	ox2_on Hub2?	ConSurf1	ConSurf2
1	2x66	NT.Y42	ox2_off	29.94	0	Yes	No	Yes	No	5	4
2	2x66	E1x49	ox2_off	14.2679	2.4568	Yes	No	Yes	No	5	5
3	NT.E46	NT.Y42	ox2_off	19.0239	0	No	No	Yes	No	7	4
4	NT.E46	NT.K51	ox2_off	16.824	0	No	No	Yes	No	7	4
5	1x39	2x60	ox2_off	15.0131	0	Yes	Yes	Yes	No	7	7
6	2x60	Lig	ox2_off	20.6537	9.09851	Yes	No	Yes	Yes	7	0
7	3x28	3x29	ox2_off	59.4229	5.31805	No	No	No	No	5	5
8	3x28	E1x50	ox2_off	57.7307	0	No	No	Yes	Yes	5	7
9	E1x50	E1x52	ox2_off	53.803	4.93365	Yes	Yes	No	No	7	6
10	2x62	E1x52	ox2_off	52.0544	0	No	No	No	No	4	6
11	2x62	2x66	ox2_off	51.3003	1.23007	No	No	Yes	No	4	5
12	3x32	Lig	ox2_off	19.7334	8.30297	No	Yes	Yes	Yes	7	0
13	1x39	7x39	ox2_off	14.2798	8.9414	Yes	Yes	Yes	Yes	7	5
14	1x53	8x50	ox2_off	11.1715	0	No	No	Yes	Yes	9	8
15	7x53	8x50	ox2_off	51.5853	0	Yes	Yes	Yes	Yes	9	8
16	3x36	6x48	ox2_off	99.9792	0	No	No	Yes	Yes	6	7
17	3x36	Lig	ox2_off	100	1.23341	No	No	Yes	Yes	6	0
18	8x50	8x54	ox2_off	16.4232	0	Yes	Yes	No	Yes	8	7
19	1x57	2x44	ox2_off	10.0968	1.16322	No	No	No	No	7	6
20	1x57	8x50	ox2_off	11.0438	0	No	No	Yes	Yes	7	8
21	2x551	2x56	ox2_off	11.2487	0	Yes	No	No	No	5	7
22	2x56	3x32	ox2_off	15.5831	1.90861	No	No	No	Yes	7	7
23	8x53	I1x50	ox2_off	10.5599	5.50857	Yes	Yes	Yes	Yes	7	8
24	3x49	3x50	ox2_off	16.5242	0	No	No	No	No	9	9
25	2x39	3x50	ox2_off	20.5884	0	No	No	No	No	8	9
26	2x39	6x37	ox2_off	22.6101	0	No	No	Yes	No	8	8
27	3x46	6x37	ox2_off	63.4663	0	No	No	Yes	No	8	8
28	2x42	3x42	ox2_off	35.5183	0	Yes	Yes	No	No	8	7
29	2x45	3x42	ox2_off	36.4001	8.29629	No	No	No	No	9	7
30	2x45	4x50	ox2_off	73.4176	5.22111	No	No	No	No	9	9
31	3x38	4x50	ox2_off	74.1777	3.4696	No	No	No	No	7	9
32	3x38	4x49	ox2_off	76.422	0.681887	No	No	No	No	7	6
33	3x41	4x49	ox2_off	77.1583	1.87519	No	No	No	No	6	6
34	3x41	5x50	ox2_off	78.613	0	No	No	No	No	6	9
35	3x40	6x44	ox2_off	80.7505	6.52472	No	No	Yes	Yes	8	9
36	2x42	4x46	ox2_off	35.3729	1.89524	Yes	Yes	No	No	8	8
37	2x45	4x46	ox2_off	36.2546	1.92867	No	No	No	No	9	8
38	3x49	I2.S164	ox2_off	10.3432	5.11749	No	No	No	No	9	5
39	E2.R213	E2x51	ox2_off	12.9824	0	No	No	No	No	4	5
40	6x59	E2x51	ox2_off	14.9745	1.05291	Yes	Yes	No	No	4	5
41	4x61	E2x52	ox2_off	17.2367	0	Yes	No	Yes	Yes	6	4
42	4x61	Lig	ox2_off	28.3666	0	Yes	No	Yes	Yes	6	0
43	5x58	6x37	ox2_off	38.6207	8.05562	Yes	Yes	Yes	No	9	8
44	3x47	5x58	ox2_off	26.6655	1.08634	No	No	Yes	Yes	8	9
45	3x51	5x57	ox2_off	22.628	1.2401	Yes	Yes	No	No	8	5
46	3x47	5x57	ox2_off	24.6497	0	No	No	No	No	8	5
47	5x65	5x66	ox2_off	10.9251	0	No	Yes	Yes	No	8	5
48	5x66	6x35	ox2_off	29.0999	0	Yes	No	No	No	5	8
49	6x35	7x56	ox2_off	32.0122	0	No	No	No	No	8	7
50	6x36	7x56	ox2_off	32.6535	4.49911	No	No	No	No	8	7
51	6x36	7x53	ox2_off	33.5797	0	No	No	Yes	Yes	8	9
52	5x66	6x31	ox2_off	16.1917	8.38654	Yes	No	No	No	5	5
53	6x47	7x45	ox2_off	15.1615	1.10639	No	No	Yes	No	8	9
54	7x39	7x40	ox2_off	14.3985	0	Yes	Yes	No	No	5	8
55	6x47	7x40	ox2_off	14.2738	0	No	No	No	No	8	8
56	6x44	7x45	ox2_off	32.131	0	Yes	Yes	Yes	No	9	9
57	3x29	Lig	Shared	61.026	21.6499	No	No	Yes	Yes	5	0
58	7x49	7x53	Shared	76.1252	22.0443	No	Yes	Yes	Yes	9	9
59	7x45	7x49	Shared	80.4061	54.7415	Yes	No	No	Yes	9	9
60	6x48	7x45	Shared	48.6284	55.7108	Yes	Yes	Yes	No	7	9
61	8x50	I1x50	Shared	14.9299	17.9129	Yes	Yes	Yes	Yes	8	8
62	2x42	3x46	Shared	65.2238	26.5434	Yes	Yes	No	No	8	8
63	3x40	5x50	Shared	80.0439	20.0421	No	No	No	No	8	9
64	6x44	6x48	Shared	51.3834	36.2904	Yes	Yes	Yes	Yes	9	7
65	7x38	Lig	Shared	10.8241	12.5648	Yes	Yes	Yes	Yes	5	0
66	5x43	Lig	Shared	10.3105	17.6388	Yes	No	Yes	Yes	5	0
67	4x61	5x39	Shared	11.4357	11.7592	Yes	No	No	Yes	6	8
68	5x47	6x49	Shared	14.7785	17.9129	Yes	Yes	No	No	8	6
69	6x49	6x50	Shared	15.874	20.0321	No	No	No	No	6	9
70	6x50	7x37	Shared	16.9635	23.1607	No	No	No	No	9	6
71	6x51	7x37	Shared	18.0471	24.1903	No	Yes	No	No	7	6
72	6x51	Lig	Shared	19.1248	78.691	No	Yes	Yes	Yes	7	0
73	1x39	7x42	ox2_on	1.27954	14.3564	Yes	Yes	Yes	Yes	7	7
74	1x43	2x57	ox2_on	8.5649	13.3536	No	Yes	Yes	Yes	6	7
75	2x64	7x38	ox2_on	1.93564	10.3453	No	No	Yes	Yes	5	5
76	6x51	7x38	ox2_on	0	21.6566	No	Yes	Yes	Yes	7	5
77	6x51	7x41	ox2_on	0	100	No	Yes	No	No	7	7
78	6x48	7x41	ox2_on	1.16969	99.8997	Yes	Yes	No	No	7	7
79	2x50	7x49	ox2_on	0	43.5137	No	Yes	No	Yes	9	9
80	1x50	2x50	ox2_on	4.50956	45.9571	No	Yes	No	Yes	9	9
81	1x50	2x47	ox2_on	3.37846	42.3605	No	Yes	No	No	9	9
82	1x53	2x47	ox2_on	4.49175	39.5728	No	No	No	No	9	9
83	1x53	7x54	ox2_on	0	38.6202	No	No	No	No	9	7
84	7x54	8x50	ox2_on	0	33.984	No	No	Yes	Yes	7	8
85	7x55	8x50	ox2_on	0	15.5597	No	No	Yes	Yes	5	8
86	3x43	6x44	ox2_on	3.59518	27.212	No	No	Yes	Yes	9	9
87	3x43	7x53	ox2_on	0	15.5196	No	No	Yes	Yes	9	9
88	3x46	7x53	ox2_on	0	26.0721	No	No	Yes	Yes	8	9
89	2x46	3x43	ox2_on	2.40173	11.5419	No	Yes	No	No	9	9
90	7x27	Lig	ox2_on	0	26.8008	No	Yes	Yes	Yes	1	0
91	7x27	E2.F207	ox2_on	0	13.6979	No	Yes	Yes	Yes	1	3
92	E1x50	Lig	ox2_on	0	10.5392	Yes	Yes	Yes	Yes	7	0
93	3x29	4x65	ox2_on	1.16969	16.8967	No	No	No	No	5	6
94	4x65	E2x52	ox2_on	0	16.0444	No	No	Yes	Yes	6	4
95	3x33	Lig	ox2_on	9.08146	26.9613	Yes	No	Yes	Yes	6	0
96	3x33	4x57	ox2_on	8.83209	15.8004	Yes	No	Yes	Yes	6	7
97	4x57	5x43	ox2_on	8.11958	14.6405	Yes	Yes	Yes	No	7	5
98	3x33	4x61	ox2_on	0.997506	12.6116	Yes	No	Yes	No	6	6
99	3x40	6x48	ox2_on	0	14.6438	No	No	Yes	Yes	8	7
100	5x54	6x44	ox2_on	0	21.4627	No	No	Yes	Yes	8	9
101	3x44	5x50	ox2_on	0	17.7625	No	No	No	No	7	9
102	3x44	5x53	ox2_on	2.08408	16.6126	No	No	No	No	7	7
103	3x48	5x53	ox2_on	0	15.4561	No	No	No	No	6	7
104	3x48	3x52	ox2_on	2.08408	14.2929	No	No	Yes	Yes	6	4
105	2x42	4x42	ox2_on	0	10.1848	Yes	Yes	No	No	8	7
106	5x44	5x47	ox2_on	9.18834	13.5542	Yes	Yes	Yes	Yes	6	8
107	5x54	6x41	ox2_on	6.24035	13.2266	No	No	No	Yes	8	8
108	6x38	6x41	ox2_on	0	15.3157	No	No	No	Yes	6	8
109	5x62	6x38	ox2_on	0	11.8027	No	No	No	No	6	6
110	4x56	4x57	ox2_on	6.40066	15.3458	No	No	Yes	Yes	5	7
111	7x38	7x42	ox2_on	0	22.4989	Yes	Yes	Yes	Yes	5	7
112	2x57	7x42	ox2_on	7.4338	15.4762	Yes	Yes	Yes	Yes	7	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
7x27	NT.H49	ox2_off	5.08	0	0	2	1	2
1x39	2x60	ox2_off	4.37	0	1	2	2	1
1x39	7x42	Shared	4.965	5.62333	1	2	2	2
2x551	2x56	ox2_off	5.07	0	0	0	2	2
2x56	3x32	Shared	6.1	7.63	0	0	2	1
2x59	E1x52	ox2_off	3.465	0	0	0	2	2
2x60	2x64	ox2_off	4.34	0	1	2	1	2
2x60	7x38	Shared	4.11	5.02	1	2	1	1
2x60	7x42	Shared	10.615	8.32333	1	2	1	2
2x60	Lig	Shared	8.785	5.42667	1	2	1	0
2x64	7x38	Shared	6.93	5.04	1	0	2	1
2x67	7x27	Shared	3.49	5.04	0	2	2	1
E1x50	E1x52	Shared	17.04	13.0267	7	2	1	2
3x25	E1x50	Shared	7.18	6.53333	7	2	2	1
3x28	E1x50	ox2_off	4.11	0	0	0	2	1
E1x50	E2x50	Shared	7.835	16.1067	7	2	1	2
3x25	E2x50	Shared	7.28	6.67333	7	2	2	2
3x28	3x29	Shared	3.39	3.39	0	0	2	1
3x29	4x65	Shared	7.55	3.91333	0	0	1	2
3x29	Lig	Shared	15.23	5.99667	0	0	1	0
3x32	7x42	ox2_off	5.075	0	0	0	1	2
3x32	Lig	Shared	17.86	15.99	0	0	1	0
3x33	4x57	Shared	9.03	9.53333	1	0	1	2
3x33	4x61	Shared	5.67	6.14	1	0	1	1
3x33	5x43	ox2_off	5.19	0	1	0	1	1
3x33	Lig	Shared	4.855	4.01667	1	0	1	0
3x36	6x48	ox2_off	7.57	0	0	0	1	2
3x36	Lig	Shared	6.41	10.1867	0	0	1	0
4x57	5x43	Shared	4.98	4.15	1	0	2	1
4x61	E2x52	ox2_off	10.195	0	1	0	1	2
4x61	5x39	Shared	9.585	6.38667	1	0	1	2
4x61	Lig	ox2_off	5.69	0	1	0	1	0
5x40	E2x52	Shared	9.85	6.15667	1	3	2	2
5x43	5x461	Shared	14.27	8.64667	1	0	1	2
5x43	Lig	Shared	14.87	4.82667	1	0	1	0
6x48	7x41	Shared	7.57	6.30667	9	1	2	2
6x51	7x37	Shared	6.19	3.61333	0	2	1	2
6x51	Lig	Shared	11.425	5.70667	0	2	1	0
6x54	7x34	Shared	10.355	4.87	0	0	2	1
6x55	Lig	Shared	11.285	7.77333	0	0	1	0
6x58	7x34	Shared	6.825	5.37333	0	0	2	1
7x30	E3.F333	Shared	9.835	7.86333	0	0	2	2
7x27	7x31	Shared	12.345	4.11667	0	2	1	1
7x34	7x38	ox2_off	3.39	0	0	0	1	1
7x38	Lig	Shared	16.12	8.45333	1	2	1	0
5x40	6x55	ox2_off	5.1	0	1	3	2	1
E2.F207	E2.V209	ox2_off	3.275	0	3	0	2	1
7x34	E3.F333	ox2_off	3.215	0	0	0	1	2
3x21	E1x50	Shared	2.81	0.94	0	0	2	1
2x63	E1x50	ox2_off	2.45	0	0	0	1	1
7x30	E3.T336	ox2_off	0.795	0	0	0	2	2
E3.A334	E3.H335	Shared	0.73	1.46333	0	0	1	2
2x56	7x42	ox2_on	0	5.82333	0	0	2	2
2x63	Lig	ox2_on	0	4.28333	0	0	1	0
2x67	7x31	ox2_on	0	8.60333	0	2	2	1
E1x50	Lig	ox2_on	0	5.02333	7	2	1	0
3x28	3x32	ox2_on	0	4.57667	0	0	2	1
4x65	E2x52	ox2_on	0	5.41333	0	0	2	2
7x27	E2.K203	ox2_on	0	6.18667	0	2	1	2
7x27	E2.F207	ox2_on	0	4.27667	0	2	1	2
5x39	5x40	ox2_on	0	5.80667	0	0	2	2
6x51	7x38	ox2_on	0	7.07	0	2	1	1
6x51	7x41	ox2_on	0	3.07333	0	2	1	2
7x31	Lig	ox2_on	0	7.89	0	2	1	0
7x38	7x42	ox2_on	0	3.63	1	2	1	2
7x27	Lig	ox2_on	0	6.01667	0	2	1	0
7x34	Lig	ox2_on	0	3.14667	0	0	1	0
7x30	7x34	ox2_on	0	2.62	0	0	2	1
7x27	E3.T336	ox2_on	0	2.58333	0	2	1	2
E2.V209	Lig	ox2_on	0	2.11333	0	0	1	0
2x551	3x32	ox2_on	0	1.88667	0	0	2	1
2x59	3x32	ox2_on	0	1.52	0	0	2	1
E3.A334	Lig	ox2_on	0	0.52	0	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	ox2_off	6TPN-OX₂-HTL6641 7XRR-OX₂-Lemborexant
	ox2_on	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2

Network Difference
Value	ox2_off	ox2_on
I_min	3.365	3.05
Number of Linked Nodes	316	288
Number of Specific Nodes	42 (13.29%)	14 (4.86%)
Number of Shared Nodes	274 (86.71%)	274 (95.14%)
Number of Links	343	318
Number of Specific Links	167 (48.69%)	142 (44.65%)
Number of Shared Links	176 (51.31%)	176 (55.35%)
Number of Hubs	43	42
Number of Specific Hubs	18 (41.86%)	17 (40.48%)
Number of Shared Hubs	25 (58.14%)	25 (59.52%)
Average % Shared Neighbours (Jaccard)	36.26
Average % Shared Neighbours (Otsuka)	45.59
Average % Shared Neighbours (Overlap Coefficient)	55.26
Average % Shared Cliques (k3-6)	80.30
Graphlets Similarity	0.613142

Paths Difference
Value	ox2_off	ox2_on
Number Of Nodes in MetaPath	71	54
Specific Nodes in MetaPath	45 (63.38%)	28 (51.85%)
Shared Nodes in MetaPath	274 (86.71%)	274 (86.71%)
Number Of Links MetaPath	72	56
Specific Links in MetaPath	56 (77.78%)	40 (71.43%)
Shared Links in MetaPath	176 (51.31%)	176 (51.31%)
Number of Shortest Paths	73160	57601
Length Of Smallest Path	3	3
Average Path Length	16.4989	12.5935
Length of Longest Path	37	28
Minimum Path Strength	0.7425	0.513333
Average Path Strength	6.71093	5.30312
Maximum Path Strength	20.9225	20.0867
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.924465	0.921934
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.125	4.16667
Average % Of Corr. Nodes	44.2464	49.3482
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	38.3685	45.4323
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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