psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Orange: nodes, hubs and links specific of peptide_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of peptide_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	peptide_off Int. Strength	peptide_on Int. Strength	peptide_off Hub1?	peptide_on Hub1?	peptide_off Hub2?	peptide_on Hub2?	ConSurf1	ConSurf2
1	1x50	2x47	peptide_off	100	0	Yes	No	No	No	9	9
2	1x53	7x53	peptide_off	100	0	No	No	Yes	Yes	9	9
3	2x38	3x49	peptide_off	100	0	No	No	No	No	7	9
4	2x39	3x50	peptide_off	100	0	No	No	Yes	No	8	9
5	2x60	7x42	peptide_off	100	0	No	No	No	No	7	7
6	E1x49	E1x51	peptide_off	100	0	No	No	No	No	4	4
7	E1x50	E2	peptide_off	100	0	Yes	Yes	Yes	Yes	8	3
8	3x30	4x54	peptide_off	100	0	No	No	No	No	6	4
9	3x37	3x41	peptide_off	100	0	Yes	Yes	No	No	7	6
10	3x40	6x44	peptide_off	100	0	No	No	No	No	8	9
11	3x43	6x44	peptide_off	100	0	No	No	No	No	8	9
12	3x44	5x54	peptide_off	100	0	No	No	No	No	7	8
13	3x46	6x37	peptide_off	100	0	No	No	No	No	9	8
14	3x49	3x50	peptide_off	100	0	No	No	Yes	No	9	9
15	3x50	6x33	peptide_off	100	0	Yes	No	No	No	9	9
16	3x50	6x34	peptide_off	100	0	Yes	No	No	No	9	8
17	3x50	6x37	peptide_off	100	0	Yes	No	No	No	9	8
18	3x54	6x30	peptide_off	100	0	No	No	No	Yes	9	8
19	5x39	E2	peptide_off	100	0	Yes	No	Yes	Yes	8	3
20	5x39	5x43	peptide_off	100	0	Yes	No	No	No	8	7
21	5x54	6x41	peptide_off	100	0	No	No	No	No	8	8
22	5x58	6x38	peptide_off	100	0	Yes	Yes	No	No	9	7
23	6x40	7x49	peptide_off	100	0	No	No	Yes	Yes	9	9
24	6x48	6x52	peptide_off	100	0	Yes	Yes	No	No	8	7
25	7x49	7x53	peptide_off	100	0	Yes	Yes	Yes	Yes	9	9
26	1x35	2x64	peptide_off	100	0	No	No	No	No	4	6
27	4x65	Lig	peptide_off	100	0	No	No	Yes	Yes	6	0
28	5x47	5x51	peptide_off	100	0	No	No	No	No	8	6
29	6x48	Lig	peptide_off	100	0	Yes	Yes	Yes	Yes	8	0
30	6x39	7x56	peptide_off	100	0	No	No	No	No	7	7
31	7x53	8x50	peptide_off	100	0	Yes	Yes	No	Yes	9	0
32	7x54	8x54	peptide_off	100	0	No	No	No	No	8	0
33	8x50	8x54	peptide_off	100	0	No	Yes	No	No	0	0
34	6x51	7x37	peptide_off	54.8611	0	No	Yes	No	No	7	6
35	7x54	8x51	peptide_off	41.6667	0	No	No	No	No	8	0
36	6x36	7x53	peptide_off	44.4444	0	No	No	Yes	Yes	9	9
37	3x37	4x53	peptide_off	42.3611	0	Yes	Yes	No	No	7	8
38	5x44	5x48	peptide_off	41.6667	0	No	No	No	No	7	6
39	1x35	1x39	peptide_off	43.75	0	No	No	Yes	No	4	7
40	6x57	6x61	peptide_off	18.75	0	No	No	No	No	5	4
41	2x48	4x50	peptide_off	41.6667	0	No	No	No	No	6	9
42	5x40	Lig	peptide_off	42.3611	0	No	No	Yes	Yes	6	0
43	2x66	E1x51	peptide_off	52.7778	0	No	No	No	No	4	4
44	3x54	5x65	peptide_off	47.2222	0	No	No	No	No	9	9
45	3x51	5x61	peptide_off	45.8333	0	Yes	Yes	No	No	8	9
46	1x56	8x53	peptide_off	58.6806	0	No	No	No	No	8	0
47	1x42	7x43	peptide_off	40.2778	0	No	No	No	No	7	5
48	3x50	3x53	peptide_off	59.0278	0	Yes	No	No	No	9	8
49	3x56	I2	peptide_off	25	0	Yes	Yes	No	No	6	0
50	5x37	6x59	peptide_off	25	0	No	No	No	No	4	6
51	1x52	8x58	peptide_off	43.4028	0	No	No	No	No	7	0
52	2x49	3x38	peptide_off	27.7778	0	No	No	No	No	8	8
53	3x51	3x52	peptide_off	33.3333	0	Yes	Yes	No	No	8	6
54	1x45	7x51	peptide_off	16.6667	0	No	No	No	No	5	6
55	7x31	7x35	peptide_off	34.375	0	No	No	No	No	3	5
56	5x65	6x31	peptide_off	39.2361	0	No	No	No	No	9	6
57	1x32	2x65	peptide_off	21.5278	0	No	No	No	No	4	5
58	1x55	8x57	peptide_off	14.5833	0	No	No	No	No	4	0
59	1x42	7x39	peptide_off	25	0	No	No	No	No	7	7
60	1x32	E1	peptide_off	33.3333	0	No	No	No	Yes	4	0
61	2x52	3x31	peptide_off	33.3333	0	No	No	Yes	No	7	5
62	5x34	5x35	peptide_off	25	0	No	No	No	No	2	4
63	5x41	6x60	peptide_off	25	0	No	No	No	No	6	5
64	8x51	8x55	peptide_off	27.4306	0	No	No	No	No	0	0
65	5x33	E3	peptide_off	16.6667	0	No	No	Yes	Yes	2	3
66	1x58	2x44	peptide_off	39.2361	0	No	No	No	No	3	6
67	1x31	7x35	peptide_off	8.33333	0	Yes	No	No	No	1	5
68	2x67	E1x49	peptide_off	18.75	0	No	No	No	No	4	4
69	2x41	I1x51	peptide_off	20.8333	0	Yes	No	No	No	5	8
70	4x38	4x39	peptide_off	25	0	No	No	No	No	8	4
71	5x32	E2	peptide_off	16.6667	0	No	No	Yes	Yes	5	3
72	7x29	7x32	peptide_off	16.6667	0	No	No	No	No	0	3
73	4x41	I2x56	peptide_off	15.2778	0	No	No	No	No	7	5
74	4x40	4x43	peptide_off	22.9167	0	No	No	No	No	5	5
75	6x32	8x48	peptide_off	25	0	No	No	No	No	8	6
76	3x52	I2x53	peptide_off	16.6667	0	No	No	No	No	6	8
77	5x59	5x60	peptide_off	16.6667	0	No	No	No	No	1	5
78	7x27	7x30	peptide_off	20.8333	0	No	No	No	No	0	0
79	4x41	4x44	peptide_off	25	0	No	No	No	No	7	4
80	6x35	7x56	peptide_off	20.8333	0	No	No	No	No	7	7
81	6x58	6x62	peptide_off	19.4444	0	No	No	No	No	4	0
82	1x31	1x34	peptide_off	17.7083	0	Yes	No	No	No	1	5
83	5x68	6x27	peptide_off	11.4583	0	No	No	Yes	No	7	4
84	2x55	2x551	peptide_off	8.33333	0	No	No	No	No	5	5
85	6x28	6x32	peptide_off	16.3194	0	No	No	No	No	5	8
86	5x64	6x25	peptide_off	8.33333	0	No	No	No	No	6	4
87	7x28	NT	peptide_off	19.0972	0	No	No	Yes	Yes	0	5
88	2x50	Na1	peptide_off	9.375	0	Yes	Yes	No	No	9	0
89	3x56	I2x51	peptide_off	12.5	0	Yes	Yes	No	No	6	7
90	6x24	6x27	peptide_off	10.7639	0	No	No	Yes	No	4	4
91	8x56	8x63	peptide_off	8.33333	0	No	No	No	No	0	0
92	I2x54	I2x57	peptide_off	16.6667	0	No	No	No	Yes	6	7
93	5x69	6x27	peptide_off	16.6667	0	No	No	Yes	No	5	4
94	7x25	E3	peptide_off	8.33333	0	No	No	Yes	Yes	0	3
95	5x51	5x55	peptide_off	6.25	0	No	No	No	No	6	6
96	5x72	6x26	peptide_off	8.33333	0	No	No	No	Yes	0	4
97	5x67	5x69	peptide_off	8.33333	0	No	No	No	No	5	5
98	5x70	5x72	peptide_off	8.33333	0	No	No	No	No	0	0
99	1x37	1x41	peptide_off	8.33333	0	No	No	No	No	4	4
100	8x58	8x60	peptide_off	8.33333	0	No	No	No	No	0	0
101	I2x52	I2x55	peptide_off	10.4167	0	No	No	No	No	5	5
102	5x71	6x27	peptide_off	9.375	0	No	No	Yes	No	0	4
103	5x74	5x76	peptide_off	8.33333	0	No	No	No	No	0	0
104	4x55	4x59	peptide_off	0	0	No	No	No	No	5	4
105	4x47	4x51	peptide_off	2.77778	0	No	No	No	No	4	4
106	5x69	I3	peptide_off	8.68056	0	No	No	No	No	5	0
107	6x23	6x24	peptide_off	8.33333	0	No	No	No	No	0	4
108	8x61	8x62	peptide_off	8.33333	0	No	No	No	No	0	0
109	1x27	7x32	peptide_off	8.33333	0	No	No	No	No	0	3
110	1x24	7x27	peptide_off	8.33333	0	No	No	No	No	0	0
111	5x29	E2	peptide_off	8.33333	0	No	No	Yes	Yes	0	3
112	5x75	5x76	peptide_off	8.33333	0	No	No	No	No	0	0
113	1x22	1x23	peptide_off	2.77778	0	No	No	No	No	0	0
114	4x54	4x58	peptide_off	2.08333	0	No	No	No	No	4	0
115	8x55	8x61	peptide_off	0	0	No	No	No	No	0	0
116	8x59	CT	peptide_off	4.16667	0	No	No	No	No	0	0
117	1x26	1x30	peptide_off	2.77778	0	No	No	No	No	0	1
118	5x76	6x28	peptide_off	0	0	No	No	No	No	0	5
119	5x72	5x73	peptide_off	0	0	No	No	No	No	0	0
120	6x22	6x25	peptide_off	2.08333	0	No	No	No	No	0	4
121	8x62	8x64	peptide_off	0	0	No	No	No	No	0	0
122	6x20	6x23	peptide_off	1.04167	0	No	No	No	No	0	0
123	1x22	1x25	peptide_off	0	0	No	No	No	No	0	0
124	6x63	6x64	peptide_off	0	0	No	No	No	No	0	0
125	6x21	6x25	peptide_off	0	0	No	No	No	No	0	4
126	2x60	Lig	Shared	100	100	No	No	Yes	Yes	7	0
127	3x29	Lig	Shared	100	100	No	No	Yes	Yes	6	0
128	3x32	Lig	Shared	100	100	No	No	Yes	Yes	7	0
129	3x33	Lig	Shared	100	100	No	Yes	Yes	Yes	6	0
130	4x61	Lig	Shared	100	100	No	No	Yes	Yes	7	0
131	6x51	Lig	Shared	100	100	No	Yes	Yes	Yes	7	0
132	6x55	Lig	Shared	100	100	No	No	Yes	Yes	7	0
133	6x58	Lig	Shared	100	100	No	No	Yes	Yes	4	0
134	7x34	Lig	Shared	100	100	No	No	Yes	Yes	5	0
135	7x38	Lig	Shared	100	100	No	No	Yes	Yes	6	0
136	NT	NT	Shared	100	100	Yes	Yes	Yes	Yes	5	5
137	1x35	7x35	Shared	100	100	No	No	No	No	4	5
138	1x39	2x57	Shared	100	100	Yes	No	No	No	7	7
139	1x39	2x61	Shared	100	100	Yes	No	No	No	7	6
140	1x39	7x39	Shared	100	100	Yes	No	No	No	7	7
141	1x43	1x47	Shared	100	100	No	No	No	No	5	6
142	1x43	2x57	Shared	100	100	No	No	No	No	5	7
143	1x49	7x50	Shared	100	36.7726	No	No	No	No	8	9
144	1x50	2x50	Shared	100	100	Yes	No	Yes	Yes	9	9
145	1x50	7x50	Shared	100	100	Yes	No	No	No	9	9
146	1x57	2x40	Shared	100	44.5909	No	No	Yes	Yes	7	9
147	1x57	2x44	Shared	100	100	No	No	No	No	7	6
148	1x60	I1x50	Shared	100	29.7101	Yes	Yes	No	No	6	8
149	I1x48	I1x51	Shared	100	29.4928	No	No	No	No	7	8
150	2x37	2x40	Shared	100	100	No	No	Yes	Yes	7	9
151	2x42	3x45	Shared	100	100	Yes	Yes	No	No	8	8
152	2x42	3x46	Shared	100	100	Yes	Yes	No	No	8	9
153	2x42	4x45	Shared	100	100	Yes	Yes	No	No	8	6
154	2x43	7x53	Shared	100	100	No	No	Yes	Yes	8	9
155	2x45	3x42	Shared	100	100	No	No	No	No	9	8
156	2x45	4x46	Shared	100	100	No	No	No	No	9	7
157	2x45	4x50	Shared	100	100	No	No	No	No	9	9
158	2x46	3x42	Shared	100	100	No	Yes	No	No	9	8
159	2x50	3x39	Shared	100	100	Yes	Yes	No	No	9	9
160	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	9
161	2x50	7x49	Shared	100	100	Yes	Yes	Yes	Yes	9	9
162	2x53	3x35	Shared	100	100	No	No	No	No	8	6
163	2x53	7x42	Shared	100	100	No	No	No	No	8	7
164	2x551	3x31	Shared	100	34.7826	No	No	Yes	No	5	5
165	2x57	7x42	Shared	100	100	No	No	No	No	7	7
166	2x59	E1x52	Shared	100	100	No	No	Yes	Yes	6	6
167	2x59	3x28	Shared	100	100	No	No	No	No	6	6
168	2x63	E1x50	Shared	100	100	No	No	Yes	Yes	5	8
169	E1x49	E2	Shared	100	100	No	No	Yes	Yes	4	3
170	E1x50	E1x52	Shared	100	100	Yes	Yes	Yes	Yes	8	6
171	3x25	E1x50	Shared	100	100	No	No	Yes	Yes	9	8
172	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	8	9
173	3x22	3x26	Shared	100	100	No	No	No	No	4	5
174	3x22	E2	Shared	100	100	No	No	Yes	Yes	4	3
175	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
176	3x29	4x65	Shared	100	100	No	No	No	No	6	6
177	3x30	4x62	Shared	100	100	No	No	No	No	6	6
178	3x34	4x54	Shared	100	100	No	No	No	No	6	4
179	3x36	6x48	Shared	100	100	No	No	Yes	Yes	7	8
180	3x37	4x56	Shared	100	100	Yes	Yes	No	No	7	6
181	3x37	5x461	Shared	100	100	Yes	Yes	No	No	7	7
182	3x38	4x50	Shared	100	100	No	No	No	No	8	9
183	3x40	5x50	Shared	100	100	No	No	No	No	8	9
184	3x41	4x49	Shared	100	100	No	No	No	No	6	7
185	3x47	5x54	Shared	100	100	No	No	No	No	9	8
186	3x47	5x58	Shared	100	100	No	No	Yes	Yes	9	9
187	3x51	3x55	Shared	100	100	Yes	Yes	No	No	8	7
188	3x51	5x57	Shared	100	100	Yes	Yes	No	No	8	6
189	3x51	5x60	Shared	100	100	Yes	Yes	No	No	8	5
190	3x54	5x61	Shared	100	100	No	No	No	No	9	9
191	3x55	3x56	Shared	100	100	No	No	Yes	Yes	7	6
192	4x60	5x39	Shared	100	100	No	No	Yes	No	8	8
193	4x61	5x39	Shared	100	100	No	No	Yes	No	7	8
194	4x63	4x64	Shared	100	100	No	No	No	No	5	5
195	4x64	E2	Shared	100	100	No	No	Yes	Yes	5	3
196	4x65	E2x52	Shared	100	100	No	No	No	No	6	5
197	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	3	3
198	E2	E2x51	Shared	100	100	Yes	Yes	No	No	3	4
199	E2	E2x52	Shared	100	100	Yes	Yes	No	No	3	5
200	5x36	E2	Shared	100	100	No	No	Yes	Yes	5	3
201	5x35	E2	Shared	100	100	No	No	Yes	Yes	4	3
202	5x37	6x60	Shared	100	37.4638	No	No	No	No	4	5
203	5x40	6x59	Shared	100	100	No	No	No	No	6	6
204	5x42	5x46	Shared	100	33.2007	No	No	No	No	5	5
205	5x47	6x49	Shared	100	100	No	No	No	No	8	6
206	5x47	6x52	Shared	100	100	No	No	No	No	8	7
207	5x51	6x45	Shared	100	100	No	No	No	No	6	6
208	5x58	5x61	Shared	100	24.6377	Yes	Yes	No	No	9	9
209	5x58	6x37	Shared	100	100	Yes	Yes	No	No	9	8
210	6x36	7x56	Shared	100	100	No	No	No	No	9	7
211	6x44	6x48	Shared	100	100	No	No	Yes	Yes	9	8
212	6x47	7x45	Shared	100	100	No	No	No	No	8	9
213	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
214	6x48	7x45	Shared	100	100	Yes	Yes	No	No	8	9
215	6x51	6x55	Shared	100	100	No	Yes	No	No	7	7
216	6x54	7x34	Shared	100	100	No	No	No	No	5	5
217	E3	E3	Shared	100	100	Yes	Yes	Yes	Yes	3	3
218	1x42	7x47	Shared	100	29.1745	No	No	No	No	7	7
219	E1x51	E1x52	Shared	100	43.8406	No	No	Yes	Yes	4	6
220	3x33	4x61	Shared	100	100	No	Yes	No	No	6	7
221	5x44	6x52	Shared	100	100	No	No	No	No	7	7
222	5x44	6x56	Shared	100	51.7391	No	No	No	No	7	6
223	3x36	Lig	Shared	100	100	No	No	Yes	Yes	7	0
224	E2	NT	Shared	100	100	Yes	Yes	Yes	Yes	3	5
225	1x55	1x59	Shared	100	41.8261	No	No	No	Yes	4	5
226	7x45	7x49	Shared	100	100	No	No	Yes	Yes	9	9
227	8x47	8x50	Shared	100	41.4493	No	No	No	Yes	9	0
228	1x52	8x54	Shared	100	100	No	No	No	No	7	0
229	6x26	6x30	Shared	100	20.6522	No	Yes	No	Yes	4	8
230	7x30	E3	Shared	100	41.087	No	No	Yes	Yes	0	3
231	Lig	Lig	Shared	100	100	Yes	Yes	Yes	Yes	0	0
232	5x66	6x31	Shared	25	18.1159	No	No	No	No	6	6
233	2x62	E1x52	Shared	56.25	33.5145	No	No	Yes	Yes	5	6
234	1x45	7x47	Shared	48.2639	31.3278	No	No	No	No	5	7
235	3x38	4x53	Shared	50	51.5942	No	No	No	No	8	8
236	3x33	4x57	Shared	41.6667	100	No	Yes	No	No	6	8
237	1x54	2x44	Shared	59.0278	29.0217	No	No	No	No	7	6
238	2x42	4x46	Shared	54.1667	100	Yes	Yes	No	No	8	7
239	1x59	1x60	Shared	27.0833	31.7029	No	Yes	Yes	Yes	5	6
240	5x49	5x50	Shared	45.1389	100	No	No	No	No	6	9
241	3x27	3x31	Shared	28.8194	16.388	No	No	Yes	No	4	5
242	3x55	5x64	Shared	42.0139	100	No	No	No	No	7	6
243	6x57	E3	Shared	26.3889	31.5217	No	No	Yes	Yes	5	3
244	3x24	E1x52	Shared	52.0833	100	No	No	Yes	Yes	5	6
245	8x48	8x51	Shared	45.8333	100	No	No	No	No	6	0
246	2x40	I1x50	Shared	60.4167	100	Yes	Yes	No	No	9	8
247	1x54	2x48	Shared	48.9583	22.7826	No	No	No	No	7	6
248	6x49	6x50	Shared	34.7222	100	No	No	No	No	6	9
249	1x46	2x54	Shared	43.75	29.2363	No	No	No	No	8	7
250	4x59	4x60	Shared	48.6111	61.3043	No	No	No	No	4	8
251	6x54	7x33	Shared	38.1944	46.7391	No	No	No	No	5	4
252	2x56	3x32	Shared	36.1111	100	No	No	No	No	7	7
253	6x39	7x52	Shared	41.6667	11.6232	No	No	No	No	7	9
254	2x46	3x43	Shared	42.3611	100	No	Yes	No	No	9	8
255	2x54	7x46	Shared	48.2639	30.8696	No	No	No	No	7	9
256	2x41	4x42	Shared	36.1111	50.3233	Yes	No	No	No	5	7
257	3x34	4x57	Shared	27.0833	100	No	No	No	No	6	8
258	6x50	7x40	Shared	40.9722	100	No	No	No	No	9	8
259	8x47	8x49	Shared	50	32.971	No	No	No	No	9	0
260	1x43	2x58	Shared	34.0278	100	No	No	No	No	5	8
261	1x38	7x39	Shared	29.1667	42.8985	No	No	No	No	5	7
262	3x48	5x57	Shared	30.9028	27.3188	No	No	No	No	6	6
263	1x50	2x51	Shared	40.625	100	Yes	No	No	No	9	7
264	2x42	4x42	Shared	25	53.3623	Yes	Yes	No	No	8	7
265	1x36	2x65	Shared	60.7639	47.5362	No	No	No	No	5	5
266	3x37	5x46	Shared	16.6667	24.7101	Yes	Yes	No	No	7	5
267	1x60	8x53	Shared	31.9444	100	Yes	Yes	No	No	6	0
268	E3	Lig	Shared	29.1667	100	Yes	Yes	Yes	Yes	3	0
269	6x43	7x48	Shared	35.4167	49.791	No	No	No	No	6	7
270	2x41	4x39	Shared	36.4583	26.3043	Yes	No	No	No	5	4
271	3x49	I2x57	Shared	25	100	No	No	No	Yes	9	7
272	1x51	2x51	Shared	38.1944	14.7503	No	No	No	No	4	7
273	3x44	5x53	Shared	18.75	100	No	No	No	No	7	7
274	6x43	7x52	Shared	27.7778	40.5797	No	No	No	No	6	9
275	5x62	5x66	Shared	25	24.3478	No	Yes	No	No	6	6
276	5x56	5x60	Shared	25	36.5217	No	No	No	No	5	5
277	1x28	1x31	Shared	29.1667	18.8406	No	No	Yes	No	0	1
278	5x45	5x48	Shared	40.625	31.6667	No	No	No	No	3	6
279	6x27	6x31	Shared	33.3333	21.1594	Yes	No	No	No	4	6
280	2x41	4x43	Shared	29.8611	100	Yes	No	No	No	5	5
281	4x38	4x41	Shared	25	38.7681	No	No	No	No	8	7
282	1x48	1x49	Shared	10.7639	22.2464	No	No	No	No	4	8
283	2x56	3x31	Shared	19.4444	28.3556	No	No	Yes	No	7	5
284	5x34	5x38	Shared	30.5556	16.6667	No	No	No	No	2	4
285	6x49	6x53	Shared	23.9583	39.214	No	No	No	No	6	6
286	1x36	2x61	Shared	26.3889	27.971	No	No	No	No	5	6
287	1x30	1x31	Shared	25	29.3478	No	No	Yes	No	1	1
288	1x31	7x32	Shared	37.5	23.7179	Yes	No	No	No	1	3
289	6x42	6x46	Shared	25	4.34783	No	No	No	No	6	5
290	3x21	E1x50	Shared	0	10.2899	No	No	Yes	Yes	7	8
291	3x41	4x52	Shared	14.9306	26.5329	No	No	No	No	6	5
292	5x59	5x63	Shared	20.8333	11.9565	No	No	No	No	1	4
293	1x60	I1x49	Shared	20.1389	28.2609	Yes	Yes	No	No	6	6
294	7x36	7x40	Shared	11.1111	21.8562	No	No	No	No	4	8
295	1x60	8x56	Shared	25	22.7285	Yes	Yes	No	No	6	0
296	3x56	I2x52	Shared	14.2361	100	Yes	Yes	No	No	6	5
297	7x51	7x55	Shared	3.81944	33.1884	No	No	No	No	6	6
298	1x44	1x48	Shared	16.6667	6.66667	No	No	No	No	4	4
299	7x23	7x26	Shared	16.6667	9.56522	No	No	No	No	0	0
300	4x51	4x55	Shared	16.6667	0	No	No	No	No	4	5
301	4x48	4x52	Shared	4.16667	7.6087	No	No	No	No	2	5
302	7x26	E3	Shared	16.6667	37.6812	No	No	Yes	Yes	0	3
303	7x24	NT	Shared	20.8333	17.3913	No	No	Yes	Yes	0	5
304	3x56	I2x50	Shared	8.33333	4.71014	Yes	Yes	No	No	6	8
305	6x38	6x42	Shared	4.51389	7.97101	No	No	No	No	7	6
306	8x48	8x52	Shared	16.6667	13.272	No	No	No	No	6	0
307	1x40	2x61	Shared	16.6667	18.8406	No	No	No	No	4	6
308	1x29	1x32	Shared	11.1111	12.3188	No	No	No	No	0	4
309	6x29	6x32	Shared	14.5833	11.0145	No	No	No	No	6	8
310	6x63	E3	Shared	16.6667	4.34783	No	No	Yes	Yes	0	3
311	3x23	3x24	Shared	2.08333	5.7971	No	No	No	No	3	5
312	1x29	1x33	Shared	8.33333	11.0368	No	No	No	No	0	6
313	5x52	5x56	Shared	8.33333	6.34058	No	No	No	No	4	5
314	1x41	1x45	Shared	2.77778	5.57971	No	No	No	No	4	5
315	5x31	E2	Shared	10.4167	14.4928	No	No	Yes	Yes	0	3
316	2x40	I1x52	Shared	8.33333	5.21739	Yes	Yes	No	No	9	0
317	1x23	1x24	Shared	8.33333	2.17391	No	No	No	No	0	0
318	8x55	CT	Shared	2.08333	4.34783	No	No	No	No	0	0
319	2x68	E2	Shared	2.08333	4.34783	No	No	Yes	Yes	0	3
320	1x53	7x54	peptide_on	0	100	No	No	No	No	9	8
321	1x56	8x50	peptide_on	0	100	No	No	No	Yes	8	0
322	2x42	3x49	peptide_on	0	100	Yes	Yes	No	No	8	9
323	2x46	2x50	peptide_on	0	100	No	Yes	Yes	Yes	9	9
324	2x46	7x49	peptide_on	0	100	No	Yes	Yes	Yes	9	9
325	2x52	3x35	peptide_on	0	100	No	No	No	No	7	6
326	2x53	7x46	peptide_on	0	100	No	No	No	No	8	9
327	2x63	Lig	peptide_on	0	100	No	No	Yes	Yes	5	0
328	2x64	Lig	peptide_on	0	100	No	No	Yes	Yes	6	0
329	3x43	7x49	peptide_on	0	100	No	No	Yes	Yes	8	9
330	3x43	7x53	peptide_on	0	100	No	No	Yes	Yes	8	9
331	3x46	3x50	peptide_on	0	100	No	No	Yes	No	9	9
332	3x46	7x53	peptide_on	0	100	No	No	Yes	Yes	9	9
333	3x50	5x58	peptide_on	0	100	Yes	No	Yes	Yes	9	9
334	3x50	7x53	peptide_on	0	100	Yes	No	Yes	Yes	9	9
335	3x51	3x56	peptide_on	0	100	Yes	Yes	Yes	Yes	8	6
336	E2	Lig	peptide_on	0	100	Yes	Yes	Yes	Yes	3	0
337	E2x51	Lig	peptide_on	0	100	No	No	Yes	Yes	4	0
338	E2x52	Lig	peptide_on	0	100	No	No	Yes	Yes	5	0
339	5x51	6x44	peptide_on	0	100	No	No	No	No	6	9
340	5x54	5x58	peptide_on	0	100	No	No	Yes	Yes	8	9
341	5x62	6x34	peptide_on	0	100	No	Yes	No	No	6	8
342	6x40	7x52	peptide_on	0	100	No	No	No	No	9	9
343	6x40	7x53	peptide_on	0	100	No	No	Yes	Yes	9	9
344	6x51	6x52	peptide_on	0	100	No	Yes	No	No	7	7
345	6x51	7x41	peptide_on	0	100	No	Yes	No	No	7	7
346	6x61	E3	peptide_on	0	100	No	No	Yes	Yes	4	3
347	7x34	7x38	peptide_on	0	100	No	No	No	No	5	6
348	7x38	7x42	peptide_on	0	100	No	No	No	No	6	7
349	7x54	8x50	peptide_on	0	100	No	No	No	Yes	8	0
350	2x64	7x35	peptide_on	0	100	No	No	No	No	6	5
351	5x65	6x30	peptide_on	0	100	No	No	No	Yes	9	8
352	5x43	Lig	peptide_on	0	100	No	No	Yes	Yes	7	0
353	7x31	Lig	peptide_on	0	100	No	No	Yes	Yes	3	0
354	2x38	I2x57	peptide_on	0	100	No	No	No	Yes	7	7
355	Lig	NT	peptide_on	0	100	Yes	Yes	Yes	Yes	0	5
356	E1	Lig	peptide_on	0	100	No	Yes	Yes	Yes	0	0
357	3x40	6x48	peptide_on	0	100	No	No	Yes	Yes	8	8
358	E2	E3	peptide_on	0	100	Yes	Yes	Yes	Yes	3	3
359	3x33	3x37	peptide_on	0	41.6667	No	Yes	Yes	Yes	6	7
360	6x54	7x37	peptide_on	0	49.5262	No	No	No	No	5	6
361	1x53	2x47	peptide_on	0	53.7915	No	No	No	No	9	9
362	5x58	6x41	peptide_on	0	54.8495	Yes	Yes	No	No	9	8
363	3x42	4x49	peptide_on	0	37.1851	No	No	No	No	8	7
364	2x43	7x54	peptide_on	0	37.1014	No	No	No	No	8	8
365	3x44	5x50	peptide_on	0	59.7826	No	No	No	No	7	9
366	5x40	6x55	peptide_on	0	42.7536	No	No	No	No	6	7
367	5x65	6x33	peptide_on	0	39.4928	No	No	No	No	9	9
368	6x56	6x60	peptide_on	0	36.5942	No	No	No	No	6	5
369	I2x52	I2x56	peptide_on	0	26.0479	No	No	No	No	5	5
370	3x47	5x57	peptide_on	0	51.9565	No	No	No	No	9	6
371	3x30	4x57	peptide_on	0	39.2029	No	No	No	No	6	8
372	3x53	I2x57	peptide_on	0	44.9275	No	No	No	Yes	8	7
373	5x64	5x68	peptide_on	0	43.8239	No	No	No	No	6	7
374	5x47	5x48	peptide_on	0	43.966	No	No	No	No	8	6
375	7x55	8x50	peptide_on	0	50	No	No	No	Yes	6	0
376	2x37	2x39	peptide_on	0	32.7648	No	No	No	No	7	8
377	2x49	3x39	peptide_on	0	35	No	No	No	No	8	9
378	2x66	E1x49	peptide_on	0	38.4894	No	No	No	No	4	4
379	4x41	4x45	peptide_on	0	32.0234	No	No	No	No	7	6
380	1x56	8x54	peptide_on	0	31.1176	No	No	No	No	8	0
381	7x43	7x48	peptide_on	0	32.1126	No	No	No	No	5	7
382	1x46	7x47	peptide_on	0	29.4203	No	No	No	No	8	7
383	7x32	NT	peptide_on	0	24.058	No	No	Yes	Yes	3	5
384	7x28	7x32	peptide_on	0	20.2536	No	No	No	No	0	3
385	1x60	8x57	peptide_on	0	32.3913	Yes	Yes	No	No	6	0
386	4x38	4x40	peptide_on	0	32.3913	No	No	No	No	8	5
387	7x27	Lig	peptide_on	0	26.2319	No	No	Yes	Yes	0	0
388	1x57	8x50	peptide_on	0	26.9565	No	No	No	Yes	7	0
389	5x62	6x37	peptide_on	0	34.3478	No	Yes	No	No	6	8
390	5x32	5x35	peptide_on	0	23.913	No	No	No	No	5	4
391	5x61	5x65	peptide_on	0	10.8417	No	No	No	No	9	9
392	3x52	3x56	peptide_on	0	23.442	No	No	Yes	Yes	6	6
393	5x55	6x41	peptide_on	0	24.7826	No	No	No	No	6	8
394	2x67	E2	peptide_on	0	17.8986	No	No	Yes	Yes	4	3
395	2x51	2x55	peptide_on	0	24.2029	No	No	No	No	7	5
396	1x32	NT	peptide_on	0	28.6232	No	No	Yes	Yes	4	5
397	I2x53	I2x57	peptide_on	0	19.5652	No	No	No	Yes	8	7
398	8x54	8x58	peptide_on	0	25.8986	No	No	No	No	0	0
399	I2x55	I2x56	peptide_on	0	20.4348	No	No	No	No	5	5
400	6x36	6x40	peptide_on	0	10.3188	No	No	No	No	9	9
401	5x34	E2	peptide_on	0	20.2899	No	No	Yes	Yes	2	3
402	6x32	7x56	peptide_on	0	22.2826	No	No	No	No	8	7
403	6x32	6x35	peptide_on	0	24.7213	No	No	No	No	8	7
404	6x62	E2	peptide_on	0	10.1449	No	No	Yes	Yes	0	3
405	4x40	4x44	peptide_on	0	17.0702	No	No	No	No	5	4
406	7x29	7x33	peptide_on	0	20.8055	No	No	No	No	0	4
407	5x63	5x67	peptide_on	0	16.6667	No	No	No	No	4	5
408	I2x50	I2x51	peptide_on	0	15.2174	No	No	No	No	8	7
409	5x37	5x41	peptide_on	0	17.029	No	No	No	No	4	6
410	5x69	6x30	peptide_on	0	16.9565	No	No	No	Yes	5	8
411	I1x49	I1x51	peptide_on	0	16.1929	No	No	No	No	6	8
412	1x58	1x59	peptide_on	0	13.1382	No	No	No	Yes	3	5
413	5x62	6x38	peptide_on	0	19.5652	No	Yes	No	No	6	7
414	5x66	5x70	peptide_on	0	17.3913	No	No	No	No	6	0
415	6x23	6x26	peptide_on	0	16.2319	No	No	No	Yes	0	4
416	5x60	5x63	peptide_on	0	16.3043	No	No	No	No	5	4
417	8x52	8x56	peptide_on	0	12.4638	No	No	No	No	0	0
418	6x28	6x31	peptide_on	0	16.1093	No	No	No	No	5	6
419	1x34	1x38	peptide_on	0	9.05797	No	No	No	No	5	5
420	6x30	I3	peptide_on	0	13.7681	No	Yes	No	No	8	0
421	3x52	I2	peptide_on	0	8.69565	No	No	No	No	6	0
422	1x33	1x37	peptide_on	0	13.4058	No	No	No	No	6	4
423	6x24	6x25	peptide_on	0	10.8696	No	No	No	No	4	4
424	6x25	6x26	peptide_on	0	10.1449	No	No	No	Yes	4	4
425	5x33	5x34	peptide_on	0	13.0435	No	No	No	No	2	2
426	8x52	8x55	peptide_on	0	6.60535	No	No	No	No	0	0
427	5x72	I3	peptide_on	0	10.8696	No	No	No	No	0	0
428	7x25	7x26	peptide_on	0	7.3913	No	No	No	No	0	0
429	I2x51	I2x54	peptide_on	0	5.43478	No	No	No	No	7	6
430	6x21	6x22	peptide_on	0	4.34783	No	No	No	No	0	0
431	5x70	5x71	peptide_on	0	10.1449	No	No	No	No	0	0
432	1x61	8x53	peptide_on	0	4.34783	No	No	No	No	0	0
433	4x41	I1	peptide_on	0	4.34783	No	No	No	No	7	0
434	5x27	E2	peptide_on	0	4.34783	No	No	Yes	Yes	0	3
435	4x55	4x56	peptide_on	0	2.53623	No	No	No	No	5	6
436	4x43	4x47	peptide_on	0	4.34783	No	No	No	No	5	4
437	5x29	E3	peptide_on	0	4.34783	No	No	Yes	Yes	0	3
438	5x79	6x20	peptide_on	0	4.34783	No	No	No	No	0	0
439	1x22	7x23	peptide_on	0	4.34783	No	No	No	No	0	0
440	6x22	6x26	peptide_on	0	4.34783	No	No	No	Yes	0	4
441	5x30	5x35	peptide_on	0	4.34783	No	No	No	No	0	4
442	5x28	E2	peptide_on	0	4.34783	No	No	Yes	Yes	0	3
443	3x29	Ca5	peptide_on	0	4.34783	No	No	No	No	6	0
444	8x58	8x59	peptide_on	0	2.89855	No	No	No	No	0	0
445	5x24	5x27	peptide_on	0	4.34783	No	No	No	No	0	0
446	2x69	E1	peptide_on	0	4.34783	No	No	No	Yes	0	0
447	3x17	3x18	peptide_on	0	4.63768	No	No	No	No	0	0
448	1x59	8x61	peptide_on	0	4.52174	No	Yes	No	No	5	0
449	1x64	I1	peptide_on	0	4.34783	No	No	No	No	0	0
450	1x25	Lig	peptide_on	0	4.34783	No	No	Yes	Yes	0	0
451	1x24	NT	peptide_on	0	4.34783	No	No	Yes	Yes	0	5
452	5x77	5x80	peptide_on	0	4.34783	No	No	No	No	0	0
453	3x16	E1x49	peptide_on	0	4.34783	No	No	No	No	0	4
454	3x30	4x58	peptide_on	0	1.47826	No	No	No	No	6	0
455	2x36	2x37	peptide_on	0	4.34783	No	No	No	No	0	7
456	3x20	E1	peptide_on	0	4.34783	No	No	No	Yes	0	0
457	1x60	8x60	peptide_on	0	4.34783	Yes	Yes	No	No	6	0
458	5x25	5x28	peptide_on	0	4.34783	No	No	No	No	0	0
459	5x69	5x73	peptide_on	0	2.17391	No	No	No	No	5	0
460	6x60	6x64	peptide_on	0	4.34783	No	No	No	No	5	0
461	2x35	I2x54	peptide_on	0	4.34783	No	No	No	No	0	6
462	3x19	3x23	peptide_on	0	1.73913	No	No	No	No	0	3
463	1x27	7x31	peptide_on	0	4.34783	No	No	No	No	0	3
464	1x26	7x28	peptide_on	0	2.17391	No	No	No	No	0	0
465	5x24	5x26	peptide_on	0	0	No	No	No	No	0	0
466	6x65	E3	peptide_on	0	1.44928	No	No	Yes	Yes	0	3
467	1x62	1x63	peptide_on	0	0	No	No	No	No	0	0
468	3x16	3x17	peptide_on	0	2.17391	No	No	No	No	0	0
469	5x71	5x74	peptide_on	0	0.289855	No	No	No	No	0	0
470	6x19	6x22	peptide_on	0	0	No	No	No	No	0	0
471	5x78	5x79	peptide_on	0	0	No	No	No	No	0	0
472	2x34	I1	peptide_on	0	0	No	No	No	No	0	0
473	1x63	1x64	peptide_on	0	0	No	No	No	No	0	0
474	6x20	6x21	peptide_on	0	0	No	No	No	No	0	0
475	5x75	I3	peptide_on	0	0.869565	No	No	No	No	0	0
476	7x57	8x53	peptide_on	0	0	No	No	No	No	0	0
477	5x72	5x76	peptide_on	0	0.289855	No	No	No	No	0	0
478	2x70	E1	peptide_on	0	0	No	No	No	Yes	0	0
479	5x73	5x77	peptide_on	0	0	No	No	No	No	0	0

Orange: nodes, hubs and links specific of peptide_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of peptide_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	peptide_off Avg Int. Strength	peptide_on Avg Int. Strength	peptide_off Num Of Links	peptide_on Num Of Links	ConSurf
1	1x31	peptide_off	2.77778	4.34783	5	3	1
2	1x39	peptide_off	35.4167	39.8261	4	3	7
3	1x50	peptide_off	22.9167	8.69565	4	3	9
4	2x41	peptide_off	10.4167	2.17391	4	3	5
5	3x31	peptide_off	0	4.34783	4	3	5
6	3x50	peptide_off	55.5556	4.34783	6	3	9
7	5x39	peptide_off	29.8611	20.6522	4	2	8
8	6x27	peptide_off	0	0	5	1	4
9	Lig	Shared	100	98.5507	17	25	0
10	NT	Shared	16.6667	33.9855	5	8	5
11	1x60	Shared	4.16667	13.0435	5	7	6
12	2x40	Shared	8.33333	11.6812	4	4	9
13	2x42	Shared	60.4167	48.1048	5	6	8
14	2x50	Shared	33.3333	72.7899	5	5	9
15	E1x50	Shared	90.9722	66.1594	6	5	8
16	E1x52	Shared	38.8889	23.456	5	5	6
17	3x37	Shared	27.0833	44.2029	5	4	7
18	3x51	Shared	50	42.5028	5	4	8
19	3x56	Shared	4.16667	0	5	5	6
20	E2	Shared	100	95.6522	16	19	3
21	5x58	Shared	25	75.2174	4	6	9
22	6x48	Shared	92.7083	92.5725	6	5	8
23	E3	Shared	41.6667	61.4493	9	11	3
24	7x49	Shared	12.5	36.0569	4	4	9
25	7x53	Shared	35.7639	57.1015	5	5	9
26	1x59	peptide_on	0	0	2	4	5
27	2x46	peptide_on	2.77778	23.4437	2	4	9
28	3x33	peptide_on	13.8889	26.8116	3	4	6
29	I2x57	peptide_on	0	13.1522	2	4	7
30	5x62	peptide_on	0	4.34783	1	4	6
31	6x26	peptide_on	0	1.44928	2	4	4
32	6x30	peptide_on	0	1.44928	2	4	8
33	6x51	peptide_on	31.25	40.8406	3	4	7
34	8x50	peptide_on	56.9444	28.6232	3	5	0
35	E1	peptide_on	4.16667	8.26087	1	4	0

Orange: nodes, hubs and links specific of peptide_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of peptide_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	peptide_off Recurrence	peptide_on Recurrence	peptide_off Hub1?	peptide_on Hub1?	peptide_off Hub2?	peptide_on Hub2?	ConSurf1	ConSurf2
1	1x35	1x39	peptide_off	13.8728	0	No	No	Yes	No	4	7
2	2x60	7x42	peptide_off	42.6133	0	No	No	No	No	7	7
3	1x35	7x35	peptide_off	11.3444	1.20444	No	No	No	No	4	5
4	1x39	7x39	peptide_off	13.0117	5.23791	Yes	No	No	No	7	7
5	6x48	Lig	peptide_off	100	0	Yes	Yes	Yes	Yes	8	0
6	2x60	Lig	peptide_off	43.211	0.770281	No	No	Yes	Yes	7	0
7	1x57	2x44	peptide_off	15.9372	3.93544	No	No	No	No	7	6
8	1x54	2x44	peptide_off	18.387	2.62946	No	No	No	No	7	6
9	1x54	2x48	peptide_off	19.5981	1.31648	No	No	No	No	7	6
10	2x48	4x50	peptide_off	20.8014	0	No	No	No	No	6	9
11	2x45	4x50	peptide_off	35.7281	4.14551	No	No	No	No	9	9
12	2x45	3x42	peptide_off	88.5809	7.37369	No	No	No	No	9	8
13	3x43	6x44	peptide_off	90.0201	0	No	No	No	No	8	9
14	6x44	6x48	peptide_off	91.8289	3.54679	No	No	Yes	Yes	9	8
15	2x45	4x46	peptide_off	69.781	5.86114	No	No	No	No	9	7
16	2x42	4x46	peptide_off	69.0339	5.66157	Yes	Yes	No	No	8	7
17	2x42	4x42	peptide_off	13.283	7.08659	Yes	Yes	No	No	8	7
18	2x41	4x42	peptide_off	12.123	5.68257	Yes	No	No	No	5	7
19	3x46	6x37	peptide_off	57.0564	0	No	No	No	No	9	8
20	7x49	7x53	peptide_off	33.6204	0	Yes	Yes	Yes	Yes	9	9
21	4x61	Lig	peptide_off	35.1028	3.74987	No	No	Yes	Yes	7	0
22	4x61	5x39	peptide_off	35.4528	3.17566	No	No	Yes	No	7	8
23	5x39	E2	peptide_off	29.2045	0	Yes	No	Yes	Yes	8	3
24	E1x50	E2	peptide_off	21.8277	0	Yes	Yes	Yes	Yes	8	3
25	E1x50	E1x52	peptide_off	11.8242	9.0368	Yes	Yes	Yes	Yes	8	6
26	4x65	Lig	peptide_off	29.6331	0	No	No	Yes	Yes	6	0
27	4x65	E2x52	peptide_off	29.1377	1.29197	No	No	No	No	6	5
28	E2	E2x52	peptide_off	28.1664	0.220581	Yes	Yes	No	No	3	5
29	3x38	4x50	peptide_off	15.5204	2.76951	No	No	No	No	8	9
30	3x38	4x53	peptide_off	13.0117	1.38651	No	No	No	No	8	8
31	3x37	4x53	peptide_off	11.7455	0	Yes	Yes	No	No	7	8
32	3x51	5x61	peptide_off	22.9916	0	Yes	Yes	No	No	8	9
33	3x51	3x55	peptide_off	11.2422	3.03561	Yes	Yes	No	No	8	7
34	6x48	6x52	peptide_off	17.9977	0	Yes	Yes	No	No	8	7
35	5x47	6x52	peptide_off	11.7455	9.15584	No	No	No	No	8	7
36	1x42	7x39	peptide_off	10.4715	0	No	No	No	No	7	7
37	7x53	8x50	peptide_off	23.3023	0	Yes	Yes	No	Yes	9	0
38	3x54	5x61	peptide_off	19.1774	1.20794	No	No	No	No	9	9
39	8x50	8x54	peptide_off	20.1722	0	No	Yes	No	No	0	0
40	7x54	8x54	peptide_off	16.8299	0	No	No	No	No	8	0
41	3x54	5x65	peptide_off	13.7824	0	No	No	No	No	9	9
42	5x65	6x31	peptide_off	12.5241	0	No	No	No	No	9	6
43	7x54	8x51	peptide_off	15.6266	0	No	No	No	No	8	0
44	E3	Lig	peptide_off	13.3145	8.4871	Yes	Yes	Yes	Yes	3	0
45	1x39	2x57	Shared	35.3506	13.8335	Yes	No	No	No	7	7
46	2x57	7x42	Shared	39.676	20.584	No	No	No	No	7	7
47	1x50	2x50	Shared	10.4715	16.9707	Yes	No	Yes	Yes	9	9
48	2x50	7x49	Shared	17.5494	23.6756	Yes	Yes	Yes	Yes	9	9
49	7x45	7x49	Shared	49.6677	73.7159	No	No	Yes	Yes	9	9
50	6x48	7x45	Shared	51.5631	73.5128	Yes	Yes	No	No	8	9
51	2x46	3x42	Shared	89.0685	12.328	No	Yes	No	No	9	8
52	2x46	3x43	Shared	89.5482	20.9271	No	Yes	No	No	9	8
53	1x57	2x40	Shared	14.7065	26.1686	No	No	Yes	Yes	7	9
54	1x60	I1x50	Shared	10.0822	20.1919	Yes	Yes	No	No	6	8
55	2x40	I1x50	Shared	11.3444	21.0077	Yes	Yes	No	No	9	8
56	2x42	3x46	Shared	57.9844	25.1742	Yes	Yes	No	No	8	9
57	5x58	6x37	Shared	49.3099	14.3797	Yes	Yes	No	No	9	8
58	5x58	5x61	Shared	40.7691	20.8151	Yes	Yes	No	No	9	9
59	7x38	Lig	peptide_on	1.08922	15.9833	No	No	Yes	Yes	6	0
60	7x38	7x42	peptide_on	0	17.2578	No	No	No	No	6	7
61	3x36	Lig	peptide_on	0.381424	60.1975	No	No	Yes	Yes	7	0
62	3x36	6x48	peptide_on	0.71173	60.5371	No	No	Yes	Yes	7	8
63	2x53	7x42	peptide_on	2.66211	26.2246	No	No	No	No	8	7
64	2x53	7x46	peptide_on	0	28.2413	No	No	No	No	8	9
65	2x50	7x46	peptide_on	3.98333	32.996	Yes	Yes	No	No	9	9
66	3x43	7x49	peptide_on	0	79.486	No	No	Yes	Yes	8	9
67	3x43	7x53	peptide_on	0	100	No	No	Yes	Yes	8	9
68	2x43	7x53	peptide_on	1.26617	44.1406	No	No	Yes	Yes	8	9
69	2x43	7x54	peptide_on	0	43.2268	No	No	No	No	8	8
70	7x54	8x50	peptide_on	0	40.1106	No	No	No	Yes	8	0
71	1x57	8x50	peptide_on	0	30.3141	No	No	No	Yes	7	0
72	3x46	7x53	peptide_on	0	20.8396	No	No	Yes	Yes	9	9
73	2x63	Lig	peptide_on	0	14.2992	No	No	Yes	Yes	5	0
74	2x63	E1x50	peptide_on	2.22563	13.6025	No	No	Yes	Yes	5	8
75	E2	Lig	peptide_on	0	20.8011	Yes	Yes	Yes	Yes	3	0
76	3x33	Lig	peptide_on	6.75947	15.4196	No	Yes	Yes	Yes	6	0
77	3x50	7x53	peptide_on	0	53.4085	Yes	No	Yes	Yes	9	9
78	3x50	5x58	peptide_on	0	58.0442	Yes	No	Yes	Yes	9	9
79	3x47	5x58	peptide_on	6.60218	26.1791	No	No	Yes	Yes	9	9
80	3x47	5x57	peptide_on	0	25.1077	No	No	No	No	9	6
81	3x51	5x57	peptide_on	2.66211	22.7828	Yes	Yes	No	No	8	6
82	3x51	3x56	peptide_on	0	11.3862	Yes	Yes	Yes	Yes	8	6
83	6x51	6x52	peptide_on	0	16.3825	No	Yes	No	No	7	7
84	5x62	6x37	peptide_on	0	13.1368	No	Yes	No	No	6	8
85	6x40	7x53	peptide_on	0	13.9316	No	No	Yes	Yes	9	9
86	6x51	7x41	peptide_on	0	12.0969	No	Yes	No	No	7	7
87	2x42	4x45	peptide_on	1.33302	11.4422	Yes	Yes	No	No	8	6
88	5x61	5x65	peptide_on	0	18.4587	No	No	No	No	9	9
89	5x65	6x30	peptide_on	0	16.428	No	No	No	Yes	9	8
90	Lig	NT	peptide_on	0	11.2531	Yes	Yes	Yes	Yes	0	5
91	4x41	4x45	peptide_on	0	10.4968	No	No	No	No	7	6
92	2x54	7x46	peptide_on	2.66211	10.3953	No	No	No	No	7	9
93	2x46	2x50	peptide_on	0	21.7569	No	Yes	Yes	Yes	9	9
94	6x48	7x41	peptide_on	1.33302	12.223	Yes	Yes	No	No	8	7

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x60	Lig	Shared	6.58097	6.63195	1	0	1	0
3x29	Lig	Shared	5.87653	5.42866	1	1	1	0
3x32	Lig	Shared	12.6468	5.59105	1	1	1	0
3x33	Lig	Shared	4.68194	5.7804	1	1	1	0
4x61	Lig	Shared	5.38472	3.30022	1	1	1	0
6x51	Lig	Shared	6.01639	6.57851	1	1	1	0
6x55	Lig	Shared	11.591	8.3086	1	1	1	0
6x58	Lig	Shared	6.32868	7.99085	1	0	1	0
7x34	Lig	Shared	5.33924	10.3545	1	1	1	0
7x38	Lig	Shared	5.22767	5.22621	0	1	1	0
NT	NT	Shared	7.63844	3.65074	1	1	1	1
1x35	7x35	Shared	3.74663	4.47636	0	0	2	2
2x60	7x42	peptide_off	4.03014	0	1	0	1	2
2x63	E1x50	Shared	6.52299	4.90386	0	1	1	2
E1x49	E2	Shared	7.95594	5.37198	1	1	2	1
E1x50	E2	peptide_off	3.74628	0	1	1	2	1
3x22	E2	Shared	9.56014	5.93866	1	1	2	1
3x29	4x65	Shared	8.84049	8.59296	1	1	1	1
3x36	6x48	Shared	7.43483	4.37101	1	1	1	1
3x40	6x44	peptide_off	6.46299	0	0	0	2	2
4x61	5x39	Shared	5.16799	3.12928	1	1	1	2
4x64	E2	Shared	9.78785	8.40513	1	1	2	1
4x65	E2x52	Shared	4.04903	5.27951	1	0	1	1
E2	E2	Shared	54.9148	48.5846	1	1	1	1
E2	E2x51	Shared	8.9667	8.44244	1	1	1	1
E2	E2x52	Shared	5.7517	4.81391	1	1	1	1
5x36	E2	Shared	8.2784	7.55982	0	0	2	1
5x35	E2	Shared	8.96778	6.3144	1	1	2	1
5x39	E2	peptide_off	3.93316	0	1	0	2	1
5x39	5x43	peptide_off	5.04503	0	1	0	2	1
5x40	6x59	Shared	6.45309	5.14753	1	0	1	2
6x44	6x48	Shared	12.7262	8.13713	0	0	2	1
6x48	6x52	peptide_off	4.71708	0	1	0	1	2
6x48	7x41	Shared	8.1217	5.01477	1	0	1	2
6x48	7x45	Shared	6.37774	7.86155	1	0	1	2
6x51	6x55	Shared	6.39844	6.46773	1	1	1	1
6x54	7x34	Shared	6.08406	6.06992	0	0	2	1
E3	E3	Shared	6.55747	8.48264	1	1	1	1
1x35	2x64	peptide_off	3.67153	0	0	0	2	1
3x33	4x61	Shared	5.70837	5.85039	1	1	1	1
3x36	Lig	Shared	4.24208	3.99781	1	1	1	0
4x65	Lig	peptide_off	3.77747	0	1	0	1	0
E2	NT	Shared	3.99087	6.30739	1	1	1	1
6x48	Lig	peptide_off	4.47993	0	1	0	1	0
7x30	E3	Shared	3.67997	2.69308	1	0	2	1
3x33	4x57	Shared	3.54993	3.55378	1	1	1	2
6x51	7x37	peptide_off	3.51979	0	1	1	1	2
6x57	E3	Shared	3.44465	3.08869	1	0	2	1
6x57	6x61	peptide_off	3.30156	0	1	0	2	2
5x40	Lig	peptide_off	3.22684	0	1	0	1	0
2x56	3x32	Shared	3.18365	4.51112	0	0	2	1
E3	Lig	Shared	2.77896	8.58715	1	1	1	0
7x31	7x35	peptide_off	2.43608	0	0	1	1	2
1x32	E1	peptide_off	2.17208	0	0	1	2	1
5x34	5x35	peptide_off	2.15663	0	0	1	2	2
5x33	E3	peptide_off	2.02938	0	0	0	2	1
2x67	E1x49	peptide_off	1.9091	0	0	0	2	2
5x32	E2	peptide_off	1.75479	0	0	0	2	1
7x27	7x30	peptide_off	1.57396	0	0	0	1	2
6x58	6x62	peptide_off	1.38403	0	1	0	1	2
7x26	E3	Shared	1.21538	2.46599	1	1	2	1
7x24	NT	Shared	1.18403	1.06304	0	0	2	1
7x28	NT	peptide_off	1.06274	0	0	0	2	1
6x63	E3	Shared	0.852083	0.326783	1	0	2	1
7x25	E3	peptide_off	0.717222	0	0	0	2	1
5x31	E2	Shared	0.466528	0.881376	0	0	2	1
1x27	7x32	peptide_off	0.383889	0	0	0	2	2
1x24	7x27	peptide_off	0.364722	0	0	1	2	1
5x29	E2	peptide_off	0.333611	0	0	0	2	1
2x68	E2	Shared	0.2375	0.302754	0	0	2	1
1x22	1x25	peptide_off	0.114167	0	0	0	2	1
2x63	Lig	peptide_on	0	5.19087	0	1	1	0
2x64	Lig	peptide_on	0	3.11979	0	1	1	0
E2	Lig	peptide_on	0	17.1869	1	1	1	0
E2x51	Lig	peptide_on	0	5.95176	0	1	1	0
E2x52	Lig	peptide_on	0	4.47288	1	1	1	0
6x51	6x52	peptide_on	0	3.98909	1	1	1	2
6x51	7x41	peptide_on	0	3.5507	1	1	1	2
6x61	E3	peptide_on	0	4.89579	0	0	2	1
7x34	7x38	peptide_on	0	4.1482	1	1	1	1
7x38	7x42	peptide_on	0	4.13374	0	1	1	2
2x64	7x35	peptide_on	0	3.26922	0	1	1	2
5x43	Lig	peptide_on	0	4.67288	0	0	1	0
7x31	Lig	peptide_on	0	7.29914	0	1	1	0
Lig	NT	peptide_on	0	3.56237	1	1	0	1
E1	Lig	peptide_on	0	3.75542	0	1	1	0
3x40	6x48	peptide_on	0	4.26873	0	0	2	1
E2	E3	peptide_on	0	3.32518	1	1	1	1
3x33	3x37	peptide_on	0	3.09413	1	1	1	2
6x54	7x37	peptide_on	0	3.08749	0	0	2	2
5x40	6x55	peptide_on	0	2.84108	1	0	1	1
7x32	NT	peptide_on	0	2.08422	0	1	2	1
7x28	7x32	peptide_on	0	2.05819	0	0	2	2
7x27	Lig	peptide_on	0	1.9994	0	0	1	0
5x32	5x35	peptide_on	0	1.86123	0	0	2	2
2x67	E2	peptide_on	0	1.7662	0	0	2	1
1x32	NT	peptide_on	0	1.63558	0	1	2	1
5x34	E2	peptide_on	0	1.45682	0	1	2	1
6x62	E2	peptide_on	0	1.36667	0	0	2	1
5x33	5x34	peptide_on	0	0.654013	0	0	2	2
7x25	7x26	peptide_on	0	0.608652	0	0	2	2
5x27	E2	peptide_on	0	0.392609	0	1	2	1
5x29	E3	peptide_on	0	0.289891	0	0	2	1
5x28	E2	peptide_on	0	0.257754	0	1	2	1
3x29	Ca5	peptide_on	0	0.249522	1	1	1	2
2x69	E1	peptide_on	0	0.224101	0	0	2	1
1x25	Lig	peptide_on	0	0.193804	0	0	1	0
1x24	NT	peptide_on	0	0.191957	0	1	2	1
3x20	E1	peptide_on	0	0.173232	0	0	2	1
1x27	7x31	peptide_on	0	0.139674	0	0	2	1
6x65	E3	peptide_on	0	0.0952174	0	0	2	1
2x70	E1	peptide_on	0	0.00565217	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	peptide_off	cck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
	peptide_on	cck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on

Network Difference
Value	peptide_off	peptide_on
I_min	3.66285	3.11257
Number of Linked Nodes	309	334
Number of Specific Nodes	4 (1.29%)	29 (8.68%)
Number of Shared Nodes	305 (98.71%)	305 (91.32%)
Number of Links	319	354
Number of Specific Links	125 (39.19%)	160 (45.20%)
Number of Shared Links	194 (60.82%)	194 (54.80%)
Number of Hubs	25	27
Number of Specific Hubs	8 (32.00%)	10 (37.04%)
Number of Shared Hubs	17 (68.00%)	17 (62.96%)
Average % Shared Neighbours (Jaccard)	43.06
Average % Shared Neighbours (Otsuka)	50.91
Average % Shared Neighbours (Overlap Coefficient)	59.03
Average % Shared Cliques (k3-6)	80.00
Graphlets Similarity	0.340911

Paths Difference
Value	peptide_off	peptide_on
Number Of Nodes in MetaPath	58	49
Specific Nodes in MetaPath	29 (50.00%)	20 (40.82%)
Shared Nodes in MetaPath	305 (98.71%)	305 (98.71%)
Number Of Links MetaPath	58	50
Specific Links in MetaPath	44 (75.86%)	36 (72.00%)
Shared Links in MetaPath	194 (60.82%)	194 (60.82%)
Number of Shortest Paths	48990	55711
Length Of Smallest Path	3	3
Average Path Length	14.2843	12.0399
Length of Longest Path	30	24
Minimum Path Strength	0.548264	0.312011
Average Path Strength	4.88222	4.35938
Maximum Path Strength	10.424	12.3734
Minimum Path Correlation	0.700729	0.700047
Average Path Correlation	0.901728	0.901492
Maximum Path Correlation	0.986111	0.987306
Minimum % Of Corr. Nodes	3.57143	4.7619
Average % Of Corr. Nodes	39.1703	44.2072
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	29.9091	35.4216
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download peptide_off_on.zip<

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.