psnGPCR

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Orange: nodes, hubs and links specific of prostanoid_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of prostanoid_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	prostanoid_off Int. Strength	prostanoid_on Int. Strength	prostanoid_off Hub1?	prostanoid_on Hub1?	prostanoid_off Hub2?	prostanoid_on Hub2?	ConSurf1	ConSurf2
1	1x39	2x60	prostanoid_off	100	0	No	No	No	No	7	8
2	1x57	7x53	prostanoid_off	100	0	Yes	Yes	Yes	Yes	8	9
3	I1	I1	prostanoid_off	100	0	Yes	No	Yes	No	6	6
4	2x38	4x38	prostanoid_off	100	0	No	No	No	No	6	8
5	2x39	6x33	prostanoid_off	100	0	Yes	No	No	No	8	9
6	2x39	6x37	prostanoid_off	100	0	Yes	No	No	Yes	8	8
7	2x42	4x42	prostanoid_off	100	0	Yes	No	No	No	8	8
8	2x43	7x53	prostanoid_off	100	0	No	No	Yes	Yes	8	9
9	2x49	3x35	prostanoid_off	100	0	No	No	Yes	No	9	7
10	2x49	4x50	prostanoid_off	100	0	No	No	No	No	9	8
11	2x50	7x49	prostanoid_off	100	0	Yes	Yes	No	Yes	9	9
12	2x60	2x64	prostanoid_off	100	0	No	No	Yes	No	8	6
13	2x60	Lig	prostanoid_off	100	0	No	No	Yes	Yes	8	0
14	2x63	E1x50	prostanoid_off	100	0	No	No	Yes	No	7	6
15	2x64	Lig	prostanoid_off	100	0	Yes	No	Yes	Yes	6	0
16	3x24	E1x50	prostanoid_off	100	0	No	No	Yes	No	6	6
17	3x28	E1x50	prostanoid_off	100	0	No	Yes	Yes	No	6	6
18	E1x50	E2x50	prostanoid_off	100	0	Yes	No	No	No	6	9
19	3x25	E2	prostanoid_off	100	0	No	No	Yes	Yes	9	5
20	3x30	4x61	prostanoid_off	100	0	No	No	No	No	7	5
21	3x31	3x35	prostanoid_off	100	0	Yes	No	Yes	No	5	7
22	3x33	5x43	prostanoid_off	100	0	Yes	No	No	No	7	7
23	3x34	4x50	prostanoid_off	100	0	Yes	Yes	No	No	7	8
24	3x37	4x56	prostanoid_off	100	0	Yes	No	No	No	8	7
25	3x37	5x43	prostanoid_off	100	0	Yes	No	No	No	8	7
26	3x37	5x46	prostanoid_off	100	0	Yes	No	No	No	8	6
27	3x38	4x53	prostanoid_off	100	0	No	No	No	No	8	8
28	3x39	7x45	prostanoid_off	100	0	No	No	Yes	Yes	9	9
29	3x42	4x46	prostanoid_off	100	0	No	No	Yes	No	8	8
30	3x43	6x44	prostanoid_off	100	0	No	No	No	No	8	8
31	3x47	5x54	prostanoid_off	100	0	No	No	No	No	9	8
32	3x49	3x50	prostanoid_off	100	0	No	No	Yes	No	9	9
33	3x51	5x57	prostanoid_off	100	0	No	Yes	Yes	No	8	7
34	3x51	5x60	prostanoid_off	100	0	No	Yes	No	No	8	5
35	3x54	5x61	prostanoid_off	100	0	No	No	No	No	9	9
36	3x54	5x65	prostanoid_off	100	0	No	No	No	No	9	9
37	3x55	3x56	prostanoid_off	100	0	No	No	No	No	7	7
38	4x38	I2x53	prostanoid_off	100	0	No	No	No	No	8	8
39	4x40	I2x56	prostanoid_off	100	0	No	No	Yes	No	5	5
40	4x56	5x42	prostanoid_off	100	0	No	No	No	No	7	5
41	4x56	5x46	prostanoid_off	100	0	No	No	No	No	7	6
42	4x59	E2	prostanoid_off	100	0	No	No	Yes	Yes	8	5
43	4x59	5x39	prostanoid_off	100	0	No	No	No	No	8	8
44	5x39	E2	prostanoid_off	100	0	No	No	Yes	Yes	8	5
45	5x33	E2	prostanoid_off	100	0	No	No	Yes	Yes	3	5
46	5x33	5x36	prostanoid_off	100	0	No	No	No	No	3	5
47	5x40	6x59	prostanoid_off	100	0	No	No	No	No	7	6
48	5x41	6x60	prostanoid_off	100	0	No	No	No	No	5	4
49	5x47	6x52	prostanoid_off	100	0	No	No	No	No	7	7
50	5x51	6x49	prostanoid_off	100	0	No	No	No	No	7	7
51	6x36	7x53	prostanoid_off	100	0	No	No	Yes	Yes	8	9
52	6x40	7x52	prostanoid_off	100	0	No	No	No	No	8	8
53	6x54	7x34	prostanoid_off	100	0	Yes	No	No	No	6	6
54	6x54	7x37	prostanoid_off	100	0	Yes	No	No	No	6	7
55	6x58	7x34	prostanoid_off	100	0	No	No	No	No	6	6
56	7x32	7x35	prostanoid_off	100	0	No	No	Yes	No	2	6
57	7x51	7x54	prostanoid_off	100	0	No	Yes	No	No	7	8
58	8x51	8x55	prostanoid_off	100	0	No	No	No	No	7	4
59	1x49	7x50	prostanoid_off	100	0	Yes	No	No	No	9	9
60	NT	NT	prostanoid_off	100	0	Yes	No	Yes	No	0	0
61	E2	NT	prostanoid_off	100	0	Yes	Yes	Yes	No	5	0
62	E3	NT	prostanoid_off	100	0	Yes	Yes	Yes	No	2	0
63	7x27	NT	prostanoid_off	100	0	No	No	Yes	No	0	0
64	7x31	NT	prostanoid_off	100	0	No	No	Yes	No	0	0
65	E1x49	NT	prostanoid_off	100	0	No	No	Yes	No	4	0
66	1x55	1x60	prostanoid_off	100	0	No	No	No	No	5	6
67	2x38	I2x57	prostanoid_off	100	0	No	No	No	No	6	7
68	2x42	4x45	prostanoid_off	100	0	Yes	No	No	No	8	7
69	3x25	E1x50	prostanoid_off	100	0	No	No	Yes	No	9	6
70	3x22	E2	prostanoid_off	100	0	No	No	Yes	Yes	2	5
71	3x26	4x62	prostanoid_off	100	0	No	No	No	No	6	5
72	3x29	4x65	prostanoid_off	100	0	No	No	No	No	7	0
73	3x33	4x61	prostanoid_off	100	0	Yes	No	No	No	7	5
74	3x36	6x48	prostanoid_off	100	0	No	No	Yes	Yes	7	8
75	3x37	3x41	prostanoid_off	100	0	Yes	No	No	No	8	7
76	3x49	I2x57	prostanoid_off	100	0	No	No	No	No	9	7
77	3x50	3x54	prostanoid_off	100	0	Yes	No	No	No	9	9
78	3x50	6x31	prostanoid_off	100	0	Yes	No	No	No	9	6
79	E2x51	Lig	prostanoid_off	100	0	No	Yes	Yes	Yes	6	0
80	5x33	E3	prostanoid_off	100	0	No	No	Yes	Yes	3	2
81	5x44	5x48	prostanoid_off	100	0	No	No	No	No	7	6
82	6x33	8x47	prostanoid_off	100	0	No	No	Yes	No	9	9
83	8x47	8x48	prostanoid_off	100	0	Yes	No	Yes	No	9	6
84	8x47	8x49	prostanoid_off	100	0	Yes	No	No	No	9	7
85	8x59	8x63	prostanoid_off	100	0	No	No	No	No	4	0
86	E1	E2	prostanoid_off	100	0	No	Yes	Yes	Yes	4	5
87	7x28	NT	prostanoid_off	100	0	No	No	Yes	No	0	0
88	E1	NT	prostanoid_off	100	0	No	Yes	Yes	No	4	0
89	2x39	6x34	prostanoid_off	100	0	Yes	No	No	No	8	7
90	E1x49	E1x501	prostanoid_off	100	0	No	No	No	No	4	0
91	6x28	I2x51	prostanoid_off	100	0	No	No	No	No	5	7
92	6x29	8x48	prostanoid_off	100	0	No	Yes	Yes	No	7	6
93	1x42	7x47	prostanoid_off	66.6667	0	No	Yes	No	No	8	8
94	3x44	5x50	prostanoid_off	66.6667	0	No	No	No	No	7	8
95	1x54	2x48	prostanoid_off	33.3333	0	No	No	No	No	8	5
96	1x52	7x54	prostanoid_off	33.3333	0	No	No	No	No	6	8
97	5x29	E3	prostanoid_off	33.3333	0	No	No	Yes	Yes	0	2
98	2x54	7x46	prostanoid_off	33.3333	0	No	No	Yes	Yes	8	9
99	6x36	7x56	prostanoid_off	66.6667	0	No	No	No	No	8	8
100	3x53	I2x57	prostanoid_off	33.3333	0	No	No	No	No	9	7
101	1x43	2x58	prostanoid_off	33.3333	0	No	No	No	No	6	9
102	6x51	6x52	prostanoid_off	33.3333	0	No	No	No	No	7	7
103	5x43	6x51	prostanoid_off	33.3333	0	No	No	No	No	7	7
104	4x43	4x46	prostanoid_off	66.6667	0	No	No	Yes	No	5	8
105	2x42	3x45	prostanoid_off	66.6667	0	Yes	No	No	No	8	8
106	5x32	NT	prostanoid_off	33.3333	0	No	No	Yes	No	0	0
107	5x53	5x57	prostanoid_off	33.3333	0	No	No	Yes	No	6	7
108	6x44	6x48	prostanoid_off	33.3333	0	No	No	Yes	Yes	8	8
109	2x52	3x35	prostanoid_off	33.3333	0	No	No	Yes	No	7	7
110	2x551	3x31	prostanoid_off	66.6667	0	No	No	Yes	No	6	5
111	I2x51	I2x53	prostanoid_off	33.3333	0	No	No	No	No	7	8
112	3x47	5x57	prostanoid_off	50	0	No	No	Yes	No	9	7
113	5x51	6x45	prostanoid_off	50	0	No	No	No	No	7	6
114	8x49	8x52	prostanoid_off	33.3333	0	No	No	No	No	7	5
115	6x50	7x37	prostanoid_off	50	0	No	No	No	No	9	7
116	5x44	6x52	prostanoid_off	33.3333	0	No	No	No	No	7	7
117	5x41	6x59	prostanoid_off	50	0	No	No	No	No	5	6
118	8x54	8x57	prostanoid_off	33.3333	0	No	No	No	No	5	4
119	5x55	5x59	prostanoid_off	33.3333	0	No	No	No	No	6	4
120	4x64	5x35	prostanoid_off	33.3333	0	No	No	Yes	No	0	3
121	1x37	1x41	prostanoid_off	33.3333	0	No	No	No	No	5	5
122	5x58	6x42	prostanoid_off	33.3333	0	No	No	No	No	9	6
123	4x43	4x47	prostanoid_off	33.3333	0	No	No	No	No	5	4
124	1x36	2x64	prostanoid_off	33.3333	0	No	Yes	Yes	No	6	6
125	6x61	E3	prostanoid_off	33.3333	0	No	No	Yes	Yes	4	2
126	4x41	I2x56	prostanoid_off	33.3333	0	No	No	Yes	No	5	5
127	5x65	5x69	prostanoid_off	33.3333	0	No	No	No	No	9	5
128	5x58	6x38	prostanoid_off	33.3333	0	No	No	No	No	9	7
129	I2x50	I3	prostanoid_off	33.3333	0	No	No	No	No	9	0
130	3x48	5x57	prostanoid_off	33.3333	0	No	No	Yes	No	7	7
131	2x63	E1x52	prostanoid_off	33.3333	0	No	No	No	No	7	5
132	3x43	6x41	prostanoid_off	50	0	No	No	No	No	8	8
133	1x35	2x64	prostanoid_off	0	0	No	No	Yes	No	5	6
134	5x54	6x41	prostanoid_off	66.6667	0	No	No	No	No	8	8
135	6x43	7x52	prostanoid_off	33.3333	0	No	No	No	No	6	8
136	7x56	8x51	prostanoid_off	33.3333	0	No	No	No	No	8	7
137	7x54	8x51	prostanoid_off	33.3333	0	No	No	No	No	8	7
138	2x41	4x39	prostanoid_off	33.3333	0	No	No	No	No	6	5
139	1x38	1x39	prostanoid_off	66.6667	0	No	No	No	No	6	7
140	1x56	8x47	prostanoid_off	33.3333	0	No	No	Yes	No	7	9
141	1x59	I1	prostanoid_off	33.3333	0	No	No	Yes	No	6	6
142	1x40	2x61	prostanoid_off	0	0	No	No	No	No	5	6
143	3x52	3x56	prostanoid_off	33.3333	0	No	No	No	No	6	7
144	6x35	8x48	prostanoid_off	33.3333	0	No	No	Yes	No	7	6
145	1x49	7x47	prostanoid_off	33.3333	0	Yes	No	No	No	9	8
146	5x68	5x69	prostanoid_off	0	0	No	No	No	No	7	5
147	5x68	I3	prostanoid_off	33.3333	0	No	No	No	No	7	0
148	I1	I2x53	prostanoid_off	33.3333	0	Yes	No	No	No	6	8
149	3x47	5x58	prostanoid_off	33.3333	0	No	No	No	No	9	9
150	5x27	5x30	prostanoid_off	33.3333	0	No	No	No	No	0	0
151	7x30	E3	prostanoid_off	33.3333	0	No	No	Yes	Yes	0	2
152	1x47	2x55	prostanoid_off	0	0	No	No	No	No	7	5
153	5x41	5x45	prostanoid_off	33.3333	0	No	No	No	No	5	5
154	1x43	2x61	prostanoid_off	16.6667	0	No	No	No	No	6	6
155	8x53	I1	prostanoid_off	33.3333	0	No	Yes	Yes	No	7	6
156	1x46	2x54	prostanoid_off	33.3333	0	No	No	No	No	8	8
157	6x30	I1	prostanoid_off	33.3333	0	No	Yes	Yes	No	8	6
158	5x56	5x60	prostanoid_off	33.3333	0	No	No	No	No	4	5
159	2x67	NT	prostanoid_off	33.3333	0	No	No	Yes	No	0	0
160	1x32	1x35	prostanoid_off	33.3333	0	No	No	No	No	0	5
161	5x62	6x35	prostanoid_off	33.3333	0	Yes	No	No	No	7	7
162	5x34	5x35	prostanoid_off	0	0	No	No	Yes	No	4	3
163	1x33	1x34	prostanoid_off	33.3333	0	No	No	No	No	4	1
164	5x62	6x39	prostanoid_off	33.3333	0	Yes	No	No	No	7	6
165	2x62	2x66	prostanoid_off	33.3333	0	No	No	No	No	6	5
166	5x55	6x42	prostanoid_off	33.3333	0	No	No	No	No	6	6
167	7x26	E3	prostanoid_off	33.3333	0	No	No	Yes	Yes	0	2
168	1x32	1x34	prostanoid_off	33.3333	0	No	No	No	No	0	1
169	5x49	5x50	prostanoid_off	33.3333	0	No	No	No	No	4	8
170	8x58	8x62	prostanoid_off	33.3333	0	No	No	No	No	5	0
171	4x59	4x63	prostanoid_off	0	0	No	No	No	No	8	8
172	5x31	E2	prostanoid_off	33.3333	0	No	No	Yes	Yes	0	5
173	5x51	6x46	prostanoid_off	0	0	No	No	No	No	7	7
174	3x36	5x461	prostanoid_off	33.3333	0	No	No	No	No	7	0
175	7x27	7x29	prostanoid_off	0	0	No	No	No	No	0	0
176	3x22	3x23	prostanoid_off	33.3333	0	No	No	No	No	2	2
177	8x55	8x56	prostanoid_off	0	0	No	No	No	No	4	4
178	1x57	1x61	prostanoid_off	16.6667	0	Yes	Yes	No	Yes	8	0
179	5x48	5x52	prostanoid_off	16.6667	0	No	No	No	No	6	4
180	8x58	8x59	prostanoid_off	0	0	No	No	No	No	5	4
181	5x28	NT	prostanoid_off	0	0	No	No	Yes	No	0	0
182	1x58	2x44	prostanoid_off	16.6667	0	No	No	No	No	4	6
183	4x44	4x47	prostanoid_off	0	0	No	No	No	No	4	4
184	3x21	E1x52	prostanoid_off	0	0	No	No	No	No	5	5
185	5x67	5x68	prostanoid_off	0	0	No	Yes	No	No	4	7
186	7x36	7x37	prostanoid_off	0	0	No	No	No	No	3	7
187	5x62	5x63	prostanoid_off	0	0	Yes	No	No	No	7	3
188	5x35	5x38	prostanoid_off	0	0	Yes	No	No	No	3	5
189	5x62	5x66	prostanoid_off	0	0	Yes	No	No	No	7	6
190	6x461	6x47	prostanoid_off	0	0	No	No	No	No	0	9
191	5x70	5x71	prostanoid_off	0	0	No	No	No	No	0	0
192	4x54	4x55	prostanoid_off	0	0	No	No	No	No	4	4
193	4x48	4x52	prostanoid_off	16.6667	0	No	No	No	No	2	5
194	4x52	4x55	prostanoid_off	0	0	No	No	No	No	5	4
195	5x27	5x29	prostanoid_off	0	0	No	No	No	No	0	0
196	8x64	CT	prostanoid_off	0	0	No	No	No	No	0	0
197	8x54	8x58	prostanoid_off	0	0	No	No	No	No	5	5
198	1x43	2x57	Shared	100	100	No	No	No	Yes	6	8
199	1x47	2x51	Shared	100	100	No	No	No	Yes	7	8
200	1x49	7x51	Shared	100	100	Yes	No	No	Yes	9	7
201	1x50	2x47	Shared	100	100	Yes	Yes	No	No	9	8
202	1x50	2x50	Shared	100	100	Yes	Yes	Yes	Yes	9	9
203	1x50	2x51	Shared	100	100	Yes	Yes	No	Yes	9	8
204	1x50	7x50	Shared	100	100	Yes	Yes	No	No	9	9
205	1x51	2x51	Shared	100	16.6667	No	No	No	Yes	5	8
206	1x54	2x47	Shared	100	100	No	No	No	No	8	8
207	1x57	2x40	Shared	100	16.6667	Yes	Yes	No	Yes	8	8
208	2x39	3x46	Shared	100	100	Yes	No	No	No	8	9
209	2x39	3x50	Shared	100	100	Yes	No	Yes	No	8	9
210	2x42	3x46	Shared	100	100	Yes	No	No	No	8	9
211	2x42	3x49	Shared	100	70.8333	Yes	No	No	No	8	9
212	2x46	3x42	Shared	100	100	No	No	No	No	9	8
213	2x50	3x39	Shared	100	100	Yes	Yes	No	No	9	9
214	2x50	7x46	Shared	100	100	Yes	Yes	Yes	Yes	9	9
215	2x53	3x35	Shared	100	100	No	No	Yes	No	8	7
216	2x56	3x31	Shared	100	100	No	No	Yes	No	7	5
217	2x56	Lig	Shared	100	50	No	No	Yes	Yes	7	0
218	2x59	3x28	Shared	100	20.8333	No	No	No	Yes	7	6
219	E1x50	E2	Shared	100	100	Yes	No	Yes	Yes	6	5
220	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
221	3x27	3x31	Shared	100	50	No	No	Yes	No	5	5
222	3x29	E2	Shared	100	100	No	No	Yes	Yes	7	5
223	3x32	Lig	Shared	100	100	No	No	Yes	Yes	8	0
224	3x33	4x57	Shared	100	100	Yes	No	No	No	7	8
225	3x33	E2x52	Shared	100	100	Yes	No	No	Yes	7	7
226	3x34	3x35	Shared	100	100	Yes	Yes	Yes	No	7	7
227	3x34	3x38	Shared	100	100	Yes	Yes	No	No	7	8
228	3x34	4x54	Shared	100	100	Yes	Yes	No	No	7	4
229	3x39	7x46	Shared	100	100	No	No	Yes	Yes	9	9
230	3x40	6x48	Shared	100	100	No	No	Yes	Yes	8	8
231	3x51	3x55	Shared	100	100	No	Yes	No	No	8	7
232	3x56	I2x52	Shared	100	100	No	No	No	Yes	7	5
233	4x60	E2	Shared	100	100	No	Yes	Yes	Yes	9	5
234	4x60	5x39	Shared	100	50	No	Yes	No	No	9	8
235	5x36	E2	Shared	100	100	No	No	Yes	Yes	5	5
236	E2	E2x50	Shared	100	100	Yes	Yes	No	No	5	9
237	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	5	5
238	E2	E2x51	Shared	100	100	Yes	Yes	No	Yes	5	6
239	E2	E3	Shared	100	100	Yes	Yes	Yes	Yes	5	2
240	E2	Lig	Shared	100	100	Yes	Yes	Yes	Yes	5	0
241	7x34	E2	Shared	100	100	No	No	Yes	Yes	6	5
242	7x35	E2	Shared	100	100	Yes	No	Yes	Yes	6	5
243	7x38	E2	Shared	100	100	No	No	Yes	Yes	6	5
244	E2x51	E2x52	Shared	100	100	No	Yes	No	Yes	6	7
245	6x58	E2	Shared	100	100	No	No	Yes	Yes	6	5
246	5x37	6x59	Shared	100	50	No	No	No	No	5	6
247	5x44	6x56	Shared	100	50	No	No	No	No	7	6
248	5x46	5x50	Shared	100	16.6667	No	No	No	No	6	8
249	6x32	8x48	Shared	100	100	No	Yes	Yes	No	8	6
250	6x47	7x45	Shared	100	100	No	No	Yes	Yes	9	9
251	6x49	6x50	Shared	100	100	No	No	No	No	7	9
252	6x54	6x58	Shared	100	100	Yes	No	No	No	6	6
253	6x54	7x33	Shared	100	100	Yes	No	No	No	6	4
254	6x60	6x61	Shared	100	100	No	No	No	No	4	4
255	E3	E3	Shared	100	100	Yes	Yes	Yes	Yes	2	2
256	7x35	7x39	Shared	100	100	Yes	No	No	Yes	6	7
257	7x35	Lig	Shared	100	100	Yes	No	Yes	Yes	6	0
258	7x38	Lig	Shared	100	100	No	No	Yes	Yes	6	0
259	7x39	Lig	Shared	100	100	No	Yes	Yes	Yes	7	0
260	7x42	Lig	Shared	100	100	No	No	Yes	Yes	8	0
261	7x45	7x46	Shared	100	100	Yes	Yes	Yes	Yes	9	9
262	7x45	7x49	Shared	100	100	Yes	Yes	No	Yes	9	9
263	8x47	8x50	Shared	100	54.1667	Yes	No	No	No	9	7
264	1x42	7x43	Shared	100	100	No	Yes	No	No	8	5
265	2x37	2x40	Shared	100	50	No	No	No	Yes	7	8
266	2x45	4x46	Shared	100	50	No	No	Yes	No	8	8
267	2x64	E1	Shared	100	100	Yes	No	No	Yes	6	4
268	I2x52	I2x56	Shared	100	100	No	Yes	Yes	No	5	5
269	6x48	7x41	Shared	100	33.3333	Yes	Yes	No	No	8	8
270	6x48	7x45	Shared	100	100	Yes	Yes	Yes	Yes	8	9
271	6x51	6x55	Shared	100	100	No	No	No	No	7	7
272	2x41	4x43	Shared	100	16.6667	No	No	No	No	6	5
273	2x46	7x49	Shared	100	100	No	No	No	Yes	9	9
274	7x46	Lig	Shared	100	100	Yes	Yes	Yes	Yes	9	0
275	6x40	7x53	Shared	33.3333	100	No	No	Yes	Yes	8	9
276	3x41	4x49	Shared	66.6667	100	No	No	No	No	7	7
277	E1x49	E1x51	Shared	33.3333	16.6667	No	No	No	No	4	4
278	2x42	4x46	Shared	33.3333	16.6667	Yes	No	Yes	No	8	8
279	3x26	E2	Shared	33.3333	100	No	No	Yes	Yes	6	5
280	1x36	2x65	Shared	33.3333	100	No	Yes	No	No	6	4
281	6x50	7x40	Shared	66.6667	100	No	No	No	No	9	8
282	3x55	5x64	Shared	33.3333	50	No	No	No	No	7	7
283	6x53	6x57	Shared	33.3333	37.5	No	No	No	No	7	5
284	1x45	7x47	Shared	50	54.1667	No	No	No	No	5	8
285	7x51	7x55	Shared	50	100	No	Yes	No	No	7	6
286	6x54	6x57	Shared	33.3333	50	Yes	No	No	No	6	5
287	1x53	2x47	Shared	16.6667	50	No	No	No	No	9	8
288	1x39	2x61	Shared	33.3333	16.6667	No	No	No	No	7	6
289	7x43	7x48	Shared	33.3333	100	No	No	No	No	5	7
290	I2x54	I2x55	Shared	33.3333	16.6667	No	No	No	No	6	5
291	I2x55	I2x56	Shared	66.6667	100	No	No	Yes	No	5	5
292	1x57	2x44	Shared	33.3333	50	Yes	Yes	No	No	8	6
293	1x55	1x59	Shared	33.3333	16.6667	No	No	No	No	5	6
294	5x35	E2	Shared	33.3333	100	Yes	No	Yes	Yes	3	5
295	2x66	E1x51	Shared	0	16.6667	No	No	No	No	5	4
296	1x41	1x45	Shared	33.3333	16.6667	No	No	No	No	5	5
297	1x48	1x49	Shared	33.3333	8.33333	No	No	Yes	No	5	9
298	3x30	4x58	Shared	0	100	No	No	No	No	7	6
299	1x44	1x48	Shared	0	16.6667	No	No	No	No	5	5
300	1x56	8x54	Shared	16.6667	50	No	No	No	No	7	5
301	1x38	7x39	prostanoid_on	0	100	No	No	No	Yes	6	7
302	1x39	Lig	prostanoid_on	0	100	No	No	Yes	Yes	7	0
303	1x42	7x39	prostanoid_on	0	100	No	Yes	No	Yes	8	7
304	1x42	7x42	prostanoid_on	0	100	No	Yes	No	No	8	8
305	1x42	Lig	prostanoid_on	0	100	No	Yes	Yes	Yes	8	0
306	1x43	1x47	prostanoid_on	0	100	No	No	No	No	6	7
307	1x46	7x47	prostanoid_on	0	100	No	No	No	No	8	8
308	2x38	3x49	prostanoid_on	0	100	No	No	No	No	6	9
309	2x38	4x42	prostanoid_on	0	100	No	No	No	No	6	8
310	2x39	2x43	prostanoid_on	0	100	Yes	No	No	No	8	8
311	2x49	3x38	prostanoid_on	0	100	No	No	No	No	9	8
312	2x54	Lig	prostanoid_on	0	100	No	No	Yes	Yes	8	0
313	2x57	Lig	prostanoid_on	0	100	No	Yes	Yes	Yes	8	0
314	2x64	E2	prostanoid_on	0	100	Yes	No	Yes	Yes	6	5
315	3x32	E2x51	prostanoid_on	0	100	No	No	No	Yes	8	6
316	3x33	E2x51	prostanoid_on	0	100	Yes	No	No	Yes	7	6
317	3x34	4x53	prostanoid_on	0	100	Yes	Yes	No	No	7	8
318	3x36	Lig	prostanoid_on	0	100	No	No	Yes	Yes	7	0
319	3x46	7x53	prostanoid_on	0	100	No	No	Yes	Yes	9	9
320	3x49	I2x53	prostanoid_on	0	100	No	No	No	No	9	8
321	3x50	6x37	prostanoid_on	0	100	Yes	No	No	Yes	9	8
322	3x53	I2x53	prostanoid_on	0	100	No	No	No	No	9	8
323	I2x52	I2x57	prostanoid_on	0	100	No	Yes	No	No	5	7
324	I2x53	I2x57	prostanoid_on	0	100	No	No	No	No	8	7
325	4x38	4x41	prostanoid_on	0	100	No	No	No	No	8	5
326	4x46	4x50	prostanoid_on	0	100	Yes	No	No	No	8	8
327	4x56	5x39	prostanoid_on	0	100	No	No	No	No	7	8
328	4x60	E2x52	prostanoid_on	0	100	No	Yes	No	Yes	9	7
329	E2	E2x52	prostanoid_on	0	100	Yes	Yes	No	Yes	5	7
330	5x54	5x58	prostanoid_on	0	100	No	No	No	No	8	9
331	7x33	E3	prostanoid_on	0	100	No	No	Yes	Yes	4	2
332	7x49	7x50	prostanoid_on	0	100	No	Yes	No	No	9	9
333	7x49	7x53	prostanoid_on	0	100	No	Yes	Yes	Yes	9	9
334	1x56	8x50	prostanoid_on	0	100	No	No	No	No	7	7
335	1x57	2x43	prostanoid_on	0	100	Yes	Yes	No	No	8	8
336	1x57	7x54	prostanoid_on	0	100	Yes	Yes	No	No	8	8
337	2x46	2x50	prostanoid_on	0	100	No	No	Yes	Yes	9	9
338	3x28	3x32	prostanoid_on	0	100	No	Yes	No	No	6	8
339	6x36	6x40	prostanoid_on	0	100	No	No	No	No	8	8
340	6x36	8x47	prostanoid_on	0	100	No	No	Yes	No	8	9
341	7x43	7x47	prostanoid_on	0	100	No	No	No	No	5	8
342	3x35	Lig	prostanoid_on	0	100	Yes	No	Yes	Yes	7	0
343	5x61	5x65	prostanoid_on	0	100	No	No	No	No	9	9
344	6x31	6x35	prostanoid_on	0	100	No	No	No	No	6	7
345	4x40	4x43	prostanoid_on	0	100	No	No	No	No	5	5
346	2x60	3x28	prostanoid_on	0	100	No	No	No	Yes	8	6
347	2x67	E1	prostanoid_on	0	100	No	No	No	Yes	0	4
348	3x24	E1	prostanoid_on	0	100	No	No	No	Yes	6	4
349	3x37	5x41	prostanoid_on	0	100	Yes	No	No	No	8	5
350	3x54	5x59	prostanoid_on	0	100	No	No	No	No	9	4
351	4x60	5x37	prostanoid_on	0	100	No	Yes	No	No	9	5
352	5x37	E2x52	prostanoid_on	0	100	No	No	No	Yes	5	7
353	5x38	E2x52	prostanoid_on	0	100	No	No	No	Yes	5	7
354	5x46	6x52	prostanoid_on	0	100	No	No	No	No	6	7
355	5x53	6x41	prostanoid_on	0	100	No	No	No	No	6	8
356	5x56	6x37	prostanoid_on	0	100	No	No	No	Yes	4	8
357	5x56	6x41	prostanoid_on	0	100	No	No	No	No	4	8
358	5x64	5x68	prostanoid_on	0	100	No	No	No	No	7	7
359	5x67	6x30	prostanoid_on	0	100	No	Yes	No	Yes	4	8
360	8x52	8x55	prostanoid_on	0	100	No	No	No	No	5	4
361	2x63	E1	prostanoid_on	0	100	No	No	No	Yes	7	4
362	E1x49	E1x52	prostanoid_on	0	100	No	No	No	No	4	5
363	E1	E1x50	prostanoid_on	0	100	No	Yes	Yes	No	4	6
364	6x48	7x46	prostanoid_on	0	100	Yes	Yes	Yes	Yes	8	9
365	1x61	1x65	prostanoid_on	0	100	No	Yes	No	No	0	0
366	1x61	2x41	prostanoid_on	0	100	No	Yes	No	No	0	6
367	2x57	3x28	prostanoid_on	0	100	No	Yes	No	Yes	8	6
368	2x64	E1x50	prostanoid_on	0	100	Yes	No	Yes	No	6	6
369	2x65	E2	prostanoid_on	0	100	No	No	Yes	Yes	4	5
370	2x67	E1x52	prostanoid_on	0	100	No	No	No	No	0	5
371	4x52	4x56	prostanoid_on	0	100	No	No	No	No	5	7
372	5x34	E2	prostanoid_on	0	100	No	No	Yes	Yes	4	5
373	5x31	5x33	prostanoid_on	0	100	No	No	No	No	0	3
374	5x32	5x33	prostanoid_on	0	100	No	No	No	No	0	3
375	5x67	6x27	prostanoid_on	0	100	No	Yes	No	No	4	6
376	6x32	8x47	prostanoid_on	0	100	No	Yes	Yes	No	8	9
377	6x57	6x61	prostanoid_on	0	100	No	No	No	No	5	4
378	3x30	E2	prostanoid_on	0	61.1111	No	No	Yes	Yes	7	5
379	3x26	4x61	prostanoid_on	0	66.6667	No	No	No	No	6	5
380	4x59	4x60	prostanoid_on	0	66.6667	No	No	No	Yes	8	9
381	3x22	E1	prostanoid_on	0	66.6667	No	No	No	Yes	2	4
382	5x31	5x34	prostanoid_on	0	50	No	No	No	No	0	4
383	4x50	4x51	prostanoid_on	0	50	No	No	No	No	8	4
384	3x51	5x55	prostanoid_on	0	66.6667	No	Yes	No	No	8	6
385	3x51	5x58	prostanoid_on	0	66.6667	No	Yes	No	No	8	9
386	4x39	4x43	prostanoid_on	0	50	No	No	No	No	5	5
387	6x51	7x37	prostanoid_on	0	66.6667	No	No	No	No	7	7
388	7x52	7x53	prostanoid_on	0	55.5556	No	No	Yes	Yes	8	9
389	6x48	6x52	prostanoid_on	0	66.6667	Yes	Yes	No	No	8	7
390	3x51	3x56	prostanoid_on	0	50	No	Yes	No	No	8	7
391	1x36	1x37	prostanoid_on	0	50	No	Yes	No	No	6	5
392	5x70	I3	prostanoid_on	0	50	No	No	No	No	0	0
393	5x42	6x56	prostanoid_on	0	66.6667	No	No	No	No	5	6
394	3x47	5x52	prostanoid_on	0	66.6667	No	No	No	No	9	4
395	4x52	5x44	prostanoid_on	0	50	No	No	No	No	5	7
396	1x54	1x58	prostanoid_on	0	50	No	No	No	No	8	4
397	3x44	5x51	prostanoid_on	0	66.6667	No	No	No	No	7	7
398	7x51	7x56	prostanoid_on	0	37.5	No	Yes	No	No	7	8
399	7x36	7x40	prostanoid_on	0	55.5556	No	No	No	No	3	8
400	5x49	5x53	prostanoid_on	0	33.3333	No	No	No	No	4	6
401	2x65	NT	prostanoid_on	0	50	No	No	Yes	No	4	0
402	5x52	5x56	prostanoid_on	0	50	No	No	No	No	4	4
403	5x41	E2x51	prostanoid_on	0	55.5556	No	No	No	Yes	5	6
404	5x40	5x44	prostanoid_on	0	50	No	No	No	No	7	7
405	3x52	I2x52	prostanoid_on	0	37.5	No	No	No	Yes	6	5
406	5x49	6x44	prostanoid_on	0	33.3333	No	No	No	No	4	8
407	4x47	4x50	prostanoid_on	0	50	No	No	No	No	4	8
408	5x53	6x45	prostanoid_on	0	66.6667	No	No	No	No	6	6
409	5x65	6x30	prostanoid_on	0	50	No	No	No	Yes	9	8
410	1x52	7x55	prostanoid_on	0	20.8333	No	No	No	No	6	6
411	1x60	2x40	prostanoid_on	0	54.1667	No	No	No	Yes	6	8
412	5x63	6x34	prostanoid_on	0	50	No	No	No	No	3	7
413	3x43	7x49	prostanoid_on	0	50	No	No	No	Yes	8	9
414	5x43	5x47	prostanoid_on	0	50	No	No	No	No	7	7
415	3x23	3x26	prostanoid_on	0	50	No	No	No	No	2	6
416	2x57	2x58	prostanoid_on	0	50	No	Yes	No	No	8	9
417	5x60	6x37	prostanoid_on	0	16.6667	No	No	No	Yes	5	8
418	8x56	8x60	prostanoid_on	0	50	No	No	No	No	4	6
419	3x48	3x52	prostanoid_on	0	33.3333	No	No	No	No	7	6
420	2x51	2x55	prostanoid_on	0	4.16667	No	Yes	No	No	8	5
421	3x41	5x48	prostanoid_on	0	16.6667	No	No	No	No	7	6
422	5x59	6x37	prostanoid_on	0	33.3333	No	No	No	Yes	4	8
423	2x51	2x52	prostanoid_on	0	50	No	Yes	No	No	8	7
424	5x69	6x30	prostanoid_on	0	50	No	No	No	Yes	5	8
425	5x64	6x34	prostanoid_on	0	33.3333	No	No	No	No	7	7
426	3x45	4x45	prostanoid_on	0	33.3333	No	No	No	No	8	7
427	2x48	2x52	prostanoid_on	0	33.3333	No	No	No	No	5	7
428	6x51	7x38	prostanoid_on	0	16.6667	No	No	No	No	7	6
429	4x45	4x49	prostanoid_on	0	16.6667	No	No	No	No	7	7
430	4x40	4x44	prostanoid_on	0	54.1667	No	No	No	No	5	4
431	6x33	8x48	prostanoid_on	0	50	No	No	Yes	No	9	6
432	1x64	2x40	prostanoid_on	0	50	No	No	No	Yes	0	8
433	7x48	7x51	prostanoid_on	0	16.6667	No	No	No	Yes	7	7
434	7x32	E3	prostanoid_on	0	50	No	No	Yes	Yes	2	2
435	5x47	5x51	prostanoid_on	0	33.3333	No	No	No	No	7	7
436	1x63	1x64	prostanoid_on	0	50	No	No	No	No	0	0
437	6x26	6x29	prostanoid_on	0	50	No	No	No	Yes	0	7
438	5x45	6x52	prostanoid_on	0	22.2222	No	No	No	No	5	7
439	3x55	5x62	prostanoid_on	0	16.6667	No	No	Yes	No	7	7
440	6x28	6x29	prostanoid_on	0	50	No	No	No	Yes	5	7
441	6x34	6x38	prostanoid_on	0	33.3333	No	No	No	No	7	7
442	6x47	7x40	prostanoid_on	0	33.3333	No	No	No	No	9	8
443	2x40	I1	prostanoid_on	0	50	No	Yes	Yes	No	8	6
444	3x48	5x51	prostanoid_on	0	50	No	No	No	No	7	7
445	7x31	E2	prostanoid_on	0	16.6667	No	No	Yes	Yes	0	5
446	3x44	5x48	prostanoid_on	0	16.6667	No	No	No	No	7	6
447	6x42	6x46	prostanoid_on	0	33.3333	No	No	No	No	6	7
448	2x551	3x27	prostanoid_on	0	30.5556	No	No	No	No	6	5
449	7x30	7x32	prostanoid_on	0	16.6667	No	No	No	No	0	2
450	3x56	I2x50	prostanoid_on	0	0	No	No	No	No	7	9
451	5x57	6x41	prostanoid_on	0	11.1111	Yes	No	No	No	7	8
452	1x61	2x37	prostanoid_on	0	16.6667	No	Yes	No	No	0	7
453	8x53	8x56	prostanoid_on	0	16.6667	No	Yes	No	No	7	4
454	4x38	4x40	prostanoid_on	0	16.6667	No	No	No	No	8	5
455	6x43	7x48	prostanoid_on	0	9.72222	No	No	No	No	6	7
456	5x63	6x30	prostanoid_on	0	16.6667	No	No	No	Yes	3	8
457	8x53	8x57	prostanoid_on	0	16.6667	No	Yes	No	No	7	4
458	4x61	4x62	prostanoid_on	0	16.6667	No	No	No	No	5	5
459	4x48	4x51	prostanoid_on	0	0	No	No	No	No	2	4
460	6x32	8x51	prostanoid_on	0	16.6667	No	Yes	No	No	8	7
461	6x32	8x52	prostanoid_on	0	16.6667	No	Yes	No	No	8	5
462	1x36	1x40	prostanoid_on	0	11.1111	No	Yes	No	No	6	5
463	4x55	4x56	prostanoid_on	0	16.6667	No	No	No	No	4	7
464	6x35	8x51	prostanoid_on	0	16.6667	No	No	No	No	7	7
465	6x46	6x47	prostanoid_on	0	16.6667	No	No	No	No	7	9
466	5x67	5x71	prostanoid_on	0	20.8333	No	Yes	No	No	4	0
467	1x65	1x66	prostanoid_on	0	0	No	No	No	No	0	0
468	8x48	8x49	prostanoid_on	0	16.6667	Yes	No	No	No	6	7
469	8x55	8x59	prostanoid_on	0	16.6667	No	No	No	No	4	4
470	6x29	8x52	prostanoid_on	0	16.6667	No	Yes	No	No	7	5
471	1x61	1x62	prostanoid_on	0	16.6667	No	Yes	No	No	0	0
472	4x63	E2	prostanoid_on	0	0	No	No	Yes	Yes	8	5
473	1x59	8x53	prostanoid_on	0	16.6667	No	No	No	Yes	6	7
474	5x66	6x30	prostanoid_on	0	22.2222	No	No	No	Yes	6	8
475	8x55	8x58	prostanoid_on	0	16.6667	No	No	No	No	4	5
476	5x67	I3	prostanoid_on	0	0	No	Yes	No	No	4	0
477	2x68	E1x49	prostanoid_on	0	0	No	No	No	No	0	4
478	5x69	5x73	prostanoid_on	0	16.6667	No	No	No	No	5	0
479	1x35	1x36	prostanoid_on	0	16.6667	No	No	No	Yes	5	6
480	5x72	5x76	prostanoid_on	0	16.6667	No	Yes	No	No	0	0
481	3x21	3x23	prostanoid_on	0	0	No	No	No	No	5	2
482	5x70	5x74	prostanoid_on	0	16.6667	No	No	No	No	0	0
483	8x49	8x53	prostanoid_on	0	4.16667	No	No	No	Yes	7	7
484	1x40	2x62	prostanoid_on	0	0	No	No	No	No	5	6
485	1x34	1x35	prostanoid_on	0	16.6667	No	No	No	No	1	5
486	5x72	5x75	prostanoid_on	0	8.33333	No	Yes	No	No	0	0
487	I2x51	I2x55	prostanoid_on	0	0	No	No	No	No	7	5
488	5x72	5x73	prostanoid_on	0	8.33333	No	Yes	No	No	0	0
489	5x72	6x24	prostanoid_on	0	4.16667	No	Yes	No	No	0	0
490	6x39	6x42	prostanoid_on	0	0	No	No	No	No	6	6
491	8x61	8x62	prostanoid_on	0	0	No	No	No	No	0	0
492	6x25	6x29	prostanoid_on	0	0	No	No	No	Yes	0	7

Orange: nodes, hubs and links specific of prostanoid_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of prostanoid_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	prostanoid_off Avg Int. Strength	prostanoid_on Avg Int. Strength	prostanoid_off Num Of Links	prostanoid_on Num Of Links	ConSurf
1	1x49	prostanoid_off	16.6667	0	4	2	9
2	I1	prostanoid_off	33.3333	0	6	1	6
3	2x39	prostanoid_off	66.6667	0	5	3	8
4	2x42	prostanoid_off	33.3333	0	6	3	8
5	2x64	prostanoid_off	33.3333	0	5	3	6
6	E1x50	prostanoid_off	83.3333	0	6	3	6
7	3x31	prostanoid_off	0	0	4	2	5
8	3x33	prostanoid_off	83.3333	33.3333	4	3	7
9	3x35	prostanoid_off	66.6667	25	5	3	7
10	3x37	prostanoid_off	16.6667	0	4	1	8
11	3x50	prostanoid_off	66.6667	0	4	2	9
12	I2x56	prostanoid_off	0	0	4	2	5
13	4x46	prostanoid_off	0	0	4	3	8
14	5x35	prostanoid_off	0	0	4	1	3
15	5x57	prostanoid_off	0	0	4	1	7
16	5x62	prostanoid_off	0	0	4	1	7
17	6x54	prostanoid_off	66.6667	8.33333	5	3	6
18	7x35	prostanoid_off	33.3333	0	4	3	6
19	8x47	prostanoid_off	33.3333	0	5	3	9
20	8x48	prostanoid_off	0	0	4	3	6
21	NT	prostanoid_off	66.6667	0	12	1	0
22	1x50	Shared	33.3333	0	4	4	9
23	1x57	Shared	0	0	4	4	8
24	2x50	Shared	66.6667	15.2778	4	4	9
25	3x34	Shared	33.3333	16.6667	4	4	7
26	E2	Shared	100	100	24	23	5
27	6x48	Shared	66.6667	33.3333	5	5	8
28	E3	Shared	100	66.6667	9	5	2
29	7x45	Shared	33.3333	16.6667	5	4	9
30	7x46	Shared	33.3333	33.3333	5	5	9
31	7x53	Shared	50	40.2778	4	4	9
32	Lig	Shared	100	100	11	14	0
33	1x36	prostanoid_on	0	0	2	4	6
34	1x42	prostanoid_on	0	0	2	4	8
35	2x40	prostanoid_on	0	0	2	5	8
36	2x51	prostanoid_on	0	0	3	5	8
37	2x57	prostanoid_on	0	0	1	4	8
38	E1	prostanoid_on	33.3333	50	3	6	4
39	3x28	prostanoid_on	0	0	2	4	6
40	3x51	prostanoid_on	0	0	3	4	8
41	I2x52	prostanoid_on	0	0	2	4	5
42	4x60	prostanoid_on	0	16.6667	2	5	9
43	E2x51	prostanoid_on	66.6667	50	3	5	6
44	E2x52	prostanoid_on	33.3333	50	2	6	7
45	5x67	prostanoid_on	0	0	1	4	4
46	5x72	prostanoid_on	0	0	0	4	0
47	6x29	prostanoid_on	0	0	1	4	7
48	6x30	prostanoid_on	0	0	1	5	8
49	6x32	prostanoid_on	0	0	1	4	8
50	6x37	prostanoid_on	0	0	1	4	8
51	7x39	prostanoid_on	0	29.1667	2	4	7
52	7x49	prostanoid_on	50	16.6667	3	5	9
53	7x51	prostanoid_on	0	0	3	4	7
54	8x53	prostanoid_on	0	0	1	4	7
55	1x61	prostanoid_on	0	0	1	4	0

Orange: nodes, hubs and links specific of prostanoid_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of prostanoid_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	prostanoid_off Recurrence	prostanoid_on Recurrence	prostanoid_off Hub1?	prostanoid_on Hub1?	prostanoid_off Hub2?	prostanoid_on Hub2?	ConSurf1	ConSurf2
1	1x50	2x50	prostanoid_off	45.3661	8.48503	Yes	Yes	Yes	Yes	9	9
2	1x50	7x50	prostanoid_off	36.0176	8.85613	Yes	Yes	No	No	9	9
3	1x49	7x50	prostanoid_off	34.9422	0	Yes	No	No	No	9	9
4	1x49	7x51	prostanoid_off	23.7842	4.5083	Yes	No	No	Yes	9	7
5	7x51	7x54	prostanoid_off	21.4645	0	No	Yes	No	No	7	8
6	7x54	8x51	prostanoid_off	19.1118	0	No	No	No	No	8	7
7	7x56	8x51	prostanoid_off	15.779	0	No	No	No	No	8	7
8	6x36	7x56	prostanoid_off	14.5752	0	No	No	No	No	8	8
9	6x36	7x53	prostanoid_off	13.5988	0	No	No	Yes	Yes	8	9
10	2x50	7x49	prostanoid_off	44.7018	0	Yes	Yes	No	Yes	9	9
11	2x46	7x49	prostanoid_off	76.4691	2.69294	No	No	No	Yes	9	9
12	2x46	3x42	prostanoid_off	75.3166	1.51447	No	No	No	No	9	8
13	3x42	4x46	prostanoid_off	74.1567	0	No	No	Yes	No	8	8
14	2x42	4x46	prostanoid_off	65.8323	8.7809	Yes	No	Yes	No	8	8
15	3x49	I2x57	prostanoid_off	18.0033	0	No	No	No	No	9	7
16	2x38	I2x57	prostanoid_off	15.423	0	No	No	No	No	6	7
17	2x38	4x38	prostanoid_off	13.9292	0	No	No	No	No	6	8
18	4x38	I2x53	prostanoid_off	12.3839	0	No	No	No	No	8	8
19	3x49	3x50	prostanoid_off	14.4944	0	No	No	Yes	No	9	9
20	2x39	6x33	prostanoid_off	26.3792	0	Yes	No	No	No	8	9
21	2x56	Lig	prostanoid_off	20.0587	5.5915	No	No	Yes	Yes	7	0
22	2x56	3x31	prostanoid_off	19.1631	4.11213	No	No	Yes	No	7	5
23	3x31	3x35	prostanoid_off	15.9809	0	Yes	No	Yes	No	5	7
24	E2x51	Lig	prostanoid_off	21.4498	0	No	Yes	Yes	Yes	6	0
25	E2x51	E2x52	prostanoid_off	27.6711	0.381124	No	Yes	No	Yes	6	7
26	3x33	E2x52	prostanoid_off	26.548	2.43217	Yes	No	No	Yes	7	7
27	3x33	5x43	prostanoid_off	21.6774	0	Yes	No	No	No	7	7
28	3x37	5x43	prostanoid_off	11.2608	0	Yes	No	No	No	8	7
29	6x48	7x45	prostanoid_off	38.0547	4.83928	Yes	Yes	Yes	Yes	8	9
30	6x44	6x48	prostanoid_off	32.6335	0	No	No	Yes	Yes	8	8
31	3x43	6x44	prostanoid_off	31.47	0	No	No	No	No	8	8
32	3x43	6x41	prostanoid_off	30.2991	0	No	No	No	No	8	8
33	5x54	6x41	prostanoid_off	29.1209	0	No	No	No	No	8	8
34	3x47	5x54	prostanoid_off	27.9354	0	No	No	No	No	9	8
35	3x47	5x57	prostanoid_off	20.668	0	No	No	Yes	No	9	7
36	3x51	5x57	prostanoid_off	16.9352	0	No	Yes	Yes	No	8	7
37	3x50	3x54	prostanoid_off	11.6315	0	Yes	No	No	No	9	9
38	3x55	3x56	prostanoid_off	10.5671	0	No	No	No	No	7	7
39	E2	E3	prostanoid_off	13.4924	4.57851	Yes	Yes	Yes	Yes	5	2
40	7x34	E2	prostanoid_off	15.3349	1.07818	No	No	Yes	Yes	6	5
41	6x58	E2	prostanoid_off	15.3349	7.95346	No	No	Yes	Yes	6	5
42	6x54	7x34	prostanoid_off	14.5311	0	Yes	No	No	No	6	6
43	6x54	7x37	prostanoid_off	19.4935	0	Yes	No	No	No	6	7
44	6x50	7x37	prostanoid_off	14.6632	0	No	No	No	No	9	7
45	6x54	6x58	prostanoid_off	14.5311	6.9505	Yes	No	No	No	6	6
46	6x33	8x47	prostanoid_off	25.3111	0	No	No	Yes	No	9	9
47	8x47	8x48	prostanoid_off	11.6168	0	Yes	No	Yes	No	9	6
48	E2	NT	prostanoid_off	12.2408	0	Yes	Yes	Yes	No	5	0
49	7x46	Lig	Shared	100	100	Yes	Yes	Yes	Yes	9	0
50	2x50	7x46	Shared	57.0233	10.4659	Yes	Yes	Yes	Yes	9	9
51	2x42	3x49	Shared	30.7726	58.8285	Yes	No	No	No	8	9
52	7x45	7x46	Shared	53.397	86.5453	Yes	Yes	Yes	Yes	9	9
53	7x45	7x49	Shared	43.0978	90.5321	Yes	Yes	No	Yes	9	9
54	2x42	3x46	Shared	30.0275	65.5333	Yes	No	No	No	8	9
55	2x39	3x46	Shared	28.6328	43.6287	Yes	No	No	No	8	9
56	E2	Lig	Shared	62.973	78.1154	Yes	Yes	Yes	Yes	5	0
57	3x51	3x55	Shared	13.1364	27.6716	No	Yes	No	No	8	7
58	1x42	7x43	prostanoid_on	2.58029	20.2848	No	Yes	No	No	8	5
59	2x57	Lig	prostanoid_on	0	11.7296	No	Yes	Yes	Yes	8	0
60	7x43	7x48	prostanoid_on	1.29198	13.2641	No	No	No	No	5	7
61	7x48	7x51	prostanoid_on	0	10.3856	No	No	No	Yes	7	7
62	7x49	7x53	prostanoid_on	0	99.3681	No	Yes	Yes	Yes	9	9
63	3x46	7x53	prostanoid_on	0	89.5793	No	No	Yes	Yes	9	9
64	2x39	2x43	prostanoid_on	0	26.5333	Yes	No	No	No	8	8
65	3x35	Lig	prostanoid_on	0	10.1499	Yes	No	Yes	Yes	7	0
66	2x64	E2	prostanoid_on	0	14.2771	Yes	No	Yes	Yes	6	5
67	E1x50	E2	prostanoid_on	7.89503	13.8107	Yes	No	Yes	Yes	6	5
68	3x49	I2x53	prostanoid_on	0	55.7745	No	No	No	No	9	8
69	I2x53	I2x57	prostanoid_on	0	54.0846	No	No	No	No	8	7
70	I2x52	I2x57	prostanoid_on	0	53.0465	No	Yes	No	No	5	7
71	3x52	I2x52	prostanoid_on	0	15.8267	No	No	No	Yes	6	5
72	3x48	3x52	prostanoid_on	0	14.4376	No	No	No	No	7	6
73	3x48	5x51	prostanoid_on	0	13.0385	No	No	No	No	7	7
74	2x39	3x50	prostanoid_on	1.69572	18.9058	Yes	No	Yes	No	8	9
75	3x50	6x37	prostanoid_on	0	17.5718	Yes	No	No	Yes	9	8
76	3x56	I2x52	prostanoid_on	7.96843	35.0735	No	No	No	Yes	7	5
77	3x51	3x56	prostanoid_on	0	32.6463	No	Yes	No	No	8	7
78	1x57	2x43	prostanoid_on	0	25.2445	Yes	Yes	No	No	8	8
79	1x57	2x40	prostanoid_on	2.58029	21.3179	Yes	Yes	No	Yes	8	8
80	2x37	2x40	prostanoid_on	1.29198	15.6211	No	No	No	Yes	7	8
81	1x61	2x37	prostanoid_on	0	14.222	No	Yes	No	No	0	7
82	1x61	2x41	prostanoid_on	0	10.1901	No	Yes	No	No	0	6
83	4x60	E2	prostanoid_on	0.950633	16.0022	No	Yes	Yes	Yes	9	5
84	4x60	5x39	prostanoid_on	0.0073408	11.4638	No	Yes	No	No	9	8
85	4x56	5x39	prostanoid_on	0	10.4809	No	No	No	No	7	8
86	6x40	7x53	prostanoid_on	3.86126	31.7136	No	No	Yes	Yes	8	9
87	6x47	7x45	prostanoid_on	2.39677	12.0305	No	No	Yes	Yes	9	9
88	2x65	E2	prostanoid_on	0	10.18	No	No	Yes	Yes	4	5
89	6x36	6x40	prostanoid_on	0	30.4899	No	No	No	No	8	8
90	6x36	8x47	prostanoid_on	0	29.2362	No	No	Yes	No	8	9
91	3x55	5x64	prostanoid_on	1.34337	25.42	No	No	No	No	7	7
92	5x64	6x34	prostanoid_on	0	23.1834	No	No	No	No	7	7
93	5x63	6x34	prostanoid_on	0	20.8264	No	No	No	No	3	7
94	5x63	6x30	prostanoid_on	0	19.4574	No	No	No	Yes	3	8
95	6x32	8x47	prostanoid_on	0	25.0088	No	Yes	Yes	No	8	9
96	2x64	E1	prostanoid_on	2.85924	13.3193	Yes	No	No	Yes	6	4
97	2x67	E1	prostanoid_on	0	15.8217	No	No	No	Yes	0	4
98	E1	E1x50	prostanoid_on	0	12.878	No	Yes	Yes	No	4	6
99	5x56	6x37	prostanoid_on	0	13.0385	No	No	No	Yes	4	8
100	6x32	8x48	prostanoid_on	1.55625	11.1028	No	Yes	Yes	No	8	6
101	2x67	E1x52	prostanoid_on	0	13.4146	No	No	No	No	0	5
102	E1x49	E1x52	prostanoid_on	0	10.5862	No	No	No	No	4	5
103	1x42	Lig	prostanoid_on	0	21.358	No	Yes	Yes	Yes	8	0

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x39	2x60	prostanoid_off	4.185	0	0	0	1	1
1x43	2x57	Shared	8.69	5.90431	0	0	2	1
2x49	3x35	prostanoid_off	3.465	0	0	0	2	1
2x50	3x39	Shared	8.31333	6.86722	1	1	2	2
2x50	7x46	Shared	7.67167	5.55042	1	1	2	1
2x53	3x35	Shared	8.60667	5.54611	0	0	2	1
2x56	3x31	Shared	4.14	4.40417	0	0	1	2
2x56	Lig	Shared	4.08333	2.59944	0	0	1	0
2x60	2x64	prostanoid_off	4.80167	0	1	0	1	1
2x60	Lig	prostanoid_off	8.71667	0	1	0	1	0
2x64	Lig	prostanoid_off	5.7	0	1	1	1	0
3x28	E1x50	prostanoid_off	4.52667	0	0	0	2	2
E1x50	E2	Shared	7.11167	8.22583	1	1	2	1
E1x50	E2x50	prostanoid_off	5.87833	0	1	1	2	2
3x25	E2	prostanoid_off	4.56333	0	1	0	2	1
3x25	E2x50	Shared	7.28	7.28	1	0	2	2
3x29	E2	Shared	5.51333	8.36694	1	0	2	1
3x31	3x35	prostanoid_off	3.85833	0	0	0	2	1
3x32	Lig	Shared	8.95333	8.26764	0	0	1	0
3x33	E2x52	Shared	3.925	5.97431	0	1	2	2
3x34	3x35	Shared	8.21667	3.06583	0	0	2	1
3x39	7x45	prostanoid_off	4.63167	0	1	1	2	2
3x39	7x46	Shared	4.68	5.04111	1	1	2	1
4x59	E2	prostanoid_off	5.18	0	1	0	2	1
4x59	5x39	prostanoid_off	3.78	0	1	0	2	2
4x60	E2	Shared	9.66	11.1236	1	1	2	1
4x60	5x39	Shared	7.605	2.70208	1	1	2	2
5x39	E2	prostanoid_off	5.13667	0	1	0	2	1
5x36	E2	Shared	15.17	3.87458	1	0	2	1
E2	E2x50	Shared	3.87333	3.35111	1	1	1	2
E2	E2	Shared	93.2033	76.1479	1	1	1	1
E2	E2x51	Shared	10.2183	10.075	1	1	1	1
E2	E3	Shared	9.65	11.1432	1	1	1	2
E2	Lig	Shared	10.1667	9.08806	1	1	1	0
7x34	E2	Shared	7.295	6.08486	1	0	2	1
7x35	E2	Shared	5.09667	8.36333	1	1	1	1
7x38	E2	Shared	10.575	6.10625	1	1	1	1
E2x51	E2x52	Shared	10.2283	8.58028	1	1	1	2
6x58	E2	Shared	12.84	4.02625	1	1	2	1
5x33	E2	prostanoid_off	3.66167	0	1	0	2	1
5x33	5x36	prostanoid_off	5.72833	0	1	0	2	2
6x58	7x34	prostanoid_off	5.145	0	1	1	2	2
E3	E3	Shared	19.095	11.6192	1	1	2	2
7x32	7x35	prostanoid_off	4.34833	0	0	1	2	1
7x35	7x39	Shared	6.47833	10.6289	1	1	1	1
7x35	Lig	Shared	4.145	3.88264	1	1	1	0
7x38	Lig	Shared	11.6833	4.38736	1	1	1	0
7x39	Lig	Shared	15.7033	6.76486	1	1	1	0
7x42	Lig	Shared	10.0233	12.1111	0	1	1	0
7x45	7x46	Shared	3.455	3.47125	1	1	2	1
NT	NT	prostanoid_off	26.53	0	1	0	2	2
E2	NT	prostanoid_off	34.575	0	1	1	1	2
E3	NT	prostanoid_off	12.1617	0	1	1	2	2
7x31	NT	prostanoid_off	5.72667	0	0	0	2	2
1x42	7x43	Shared	5.165	6.71167	0	1	1	2
2x64	E1	Shared	6.29	3.05833	1	1	1	2
3x25	E1x50	prostanoid_off	3.7	0	1	0	2	2
3x22	E2	prostanoid_off	4.14667	0	1	0	2	1
3x36	6x48	prostanoid_off	5.09	0	0	0	1	2
E2x51	Lig	prostanoid_off	6.23	0	1	1	1	0
5x33	E3	prostanoid_off	5.95333	0	1	0	2	2
6x48	7x45	Shared	5.46167	7.75264	0	1	2	2
E1	E2	prostanoid_off	5.20167	0	1	1	2	1
E1	NT	prostanoid_off	7.15333	0	1	1	2	2
7x46	Lig	Shared	4.24833	5.17264	1	1	1	0
1x42	7x47	prostanoid_off	3.415	0	0	1	1	2
2x54	7x46	prostanoid_off	3.35167	0	0	0	1	1
1x43	2x58	prostanoid_off	3.26667	0	0	0	2	2
2x52	3x35	prostanoid_off	3.04667	0	0	0	2	1
3x26	E2	Shared	2.90167	3.27514	1	1	2	1
1x36	2x65	Shared	2.825	4.68833	0	0	2	2
1x36	2x64	prostanoid_off	2.77667	0	0	0	2	1
1x35	2x64	prostanoid_off	2.615	0	0	0	2	1
1x39	2x61	Shared	2.435	2.07	0	0	1	2
1x38	1x39	prostanoid_off	2.415	0	0	0	2	1
1x43	2x61	prostanoid_off	1.92167	0	0	0	2	2
5x35	E2	Shared	1.86167	3.26375	1	0	2	1
1x46	2x54	prostanoid_off	1.80667	0	0	0	2	1
5x34	5x35	prostanoid_off	1.5	0	0	1	2	2
4x59	4x63	prostanoid_off	1.10333	0	1	0	2	2
5x31	E2	prostanoid_off	1.09667	0	0	0	2	1
3x36	5x461	prostanoid_off	1.07333	0	0	0	1	2
1x38	7x39	prostanoid_on	0	8.75361	0	0	2	1
1x39	Lig	prostanoid_on	0	8.34694	0	0	1	0
1x42	7x39	prostanoid_on	0	3.26944	0	1	1	1
1x42	7x42	prostanoid_on	0	3.59889	0	1	1	1
1x42	Lig	prostanoid_on	0	4.57958	0	1	1	0
1x46	7x47	prostanoid_on	0	4.1875	0	0	2	2
2x54	Lig	prostanoid_on	0	14.2897	0	0	1	0
2x57	Lig	prostanoid_on	0	8.78181	0	0	1	0
2x64	E2	prostanoid_on	0	4.45694	1	1	1	1
3x32	E2x51	prostanoid_on	0	4.46653	0	0	1	1
3x33	E2x51	prostanoid_on	0	3.65708	0	1	2	1
3x36	Lig	prostanoid_on	0	3.34139	0	0	1	0
4x60	E2x52	prostanoid_on	0	3.38458	1	1	2	2
E2	E2x52	prostanoid_on	0	4.19083	1	1	1	2
3x28	3x32	prostanoid_on	0	4.18944	0	0	2	1
7x43	7x47	prostanoid_on	0	5.61375	0	0	2	2
3x35	Lig	prostanoid_on	0	3.585	0	0	1	0
2x60	3x28	prostanoid_on	0	10.8489	1	0	1	2
E1	E1x50	prostanoid_on	0	5.665	1	1	2	2
6x48	7x46	prostanoid_on	0	3.105	0	1	2	1
2x57	3x28	prostanoid_on	0	3.625	0	0	1	2
2x64	E1x50	prostanoid_on	0	5.31167	1	1	1	2
2x65	E2	prostanoid_on	0	5.20167	0	1	2	1
5x34	E2	prostanoid_on	0	12.575	0	1	2	1
5x31	5x33	prostanoid_on	0	4.115	0	0	2	2
3x30	E2	prostanoid_on	0	2.98	0	1	2	1
4x59	4x60	prostanoid_on	0	2.91667	1	0	2	2
3x22	E1	prostanoid_on	0	2.89	1	0	2	2
5x31	5x34	prostanoid_on	0	2.88333	0	0	2	2
2x65	NT	prostanoid_on	0	2.33333	0	1	2	2
5x41	E2x51	prostanoid_on	0	2.30889	0	0	2	1
2x57	2x58	prostanoid_on	0	2.06472	0	0	1	2
6x51	7x38	prostanoid_on	0	1.92097	0	0	2	1
7x32	E3	prostanoid_on	0	1.80375	0	1	2	2
7x31	E2	prostanoid_on	0	1.505	0	0	2	1
4x63	E2	prostanoid_on	0	0.9375	0	0	2	1
1x35	1x36	prostanoid_on	0	0.791111	0	0	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	prostanoid_off	ep_off tp_off dp_off
	prostanoid_on	ep_on fpa_on

Network Difference
Value	prostanoid_off	prostanoid_on
I_min	3.44	3.02542
Number of Linked Nodes	276	276
Number of Specific Nodes	18 (6.52%)	18 (6.52%)
Number of Shared Nodes	258 (93.48%)	258 (93.48%)
Number of Links	300	295
Number of Specific Links	197 (65.67%)	192 (65.08%)
Number of Shared Links	103 (34.33%)	103 (34.92%)
Number of Hubs	32	34
Number of Specific Hubs	21 (65.63%)	23 (67.65%)
Number of Shared Hubs	11 (34.38%)	11 (32.35%)
Average % Shared Neighbours (Jaccard)	20.92
Average % Shared Neighbours (Otsuka)	27.44
Average % Shared Neighbours (Overlap Coefficient)	34.22
Average % Shared Cliques (k3-6)	53.45
Graphlets Similarity	0.543053

Paths Difference
Value	prostanoid_off	prostanoid_on
Number Of Nodes in MetaPath	56	55
Specific Nodes in MetaPath	34 (60.71%)	33 (60.00%)
Shared Nodes in MetaPath	258 (93.48%)	258 (93.48%)
Number Of Links MetaPath	57	55
Specific Links in MetaPath	48 (84.21%)	46 (83.64%)
Shared Links in MetaPath	103 (34.33%)	103 (34.33%)
Number of Shortest Paths	49107	40696
Length Of Smallest Path	3	3
Average Path Length	13.5436	12.447
Length of Longest Path	29	30
Minimum Path Strength	0.478333	0.670694
Average Path Strength	5.41509	4.68996
Maximum Path Strength	24.8725	13.2004
Minimum Path Correlation	0.7	0.700556
Average Path Correlation	0.907942	0.89382
Maximum Path Correlation	0.986667	0.987083
Minimum % Of Corr. Nodes	4	3.57143
Average % Of Corr. Nodes	41.7294	41.1639
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	42.8684	43.0215
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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