psnGPCR

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Orange: nodes, hubs and links specific of prostanoid_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of prostanoid_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	prostanoid_off Int. Strength	prostanoid_on Int. Strength	prostanoid_off Hub1?	prostanoid_on Hub1?	prostanoid_off Hub2?	prostanoid_on Hub2?	ConSurf1	ConSurf2
1	1x37	1x41	prostanoid_off	100	0	No	No	No	No	5	5
2	1x38	1x39	prostanoid_off	100	0	No	No	Yes	No	6	7
3	1x39	2x60	prostanoid_off	100	0	Yes	No	No	No	7	8
4	1x39	2x64	prostanoid_off	100	0	Yes	No	Yes	No	7	6
5	1x42	7x47	prostanoid_off	100	0	No	No	No	No	8	8
6	1x43	2x57	prostanoid_off	100	0	Yes	No	No	Yes	6	8
7	1x57	2x40	prostanoid_off	100	0	No	No	No	Yes	8	8
8	1x59	I1	prostanoid_off	100	0	No	No	Yes	No	6	6
9	2x38	4x38	prostanoid_off	100	0	No	No	Yes	No	6	8
10	2x39	6x33	prostanoid_off	100	0	Yes	Yes	Yes	No	8	9
11	2x39	6x37	prostanoid_off	100	0	Yes	Yes	Yes	No	8	8
12	2x42	3x49	prostanoid_off	100	0	Yes	Yes	Yes	No	8	9
13	2x43	7x53	prostanoid_off	100	0	No	No	Yes	Yes	8	9
14	2x46	3x43	prostanoid_off	100	0	No	No	No	No	9	8
15	2x49	3x35	prostanoid_off	100	0	No	No	Yes	No	9	7
16	2x50	7x49	prostanoid_off	100	0	Yes	Yes	No	No	9	9
17	2x52	2x551	prostanoid_off	100	0	No	No	No	No	7	6
18	2x52	3x35	prostanoid_off	100	0	No	No	Yes	No	7	7
19	2x57	2x58	prostanoid_off	100	0	No	Yes	No	No	8	9
20	2x59	3x28	prostanoid_off	100	0	No	No	No	No	7	6
21	2x60	2x64	prostanoid_off	100	0	No	No	Yes	No	8	6
22	2x60	Lig	prostanoid_off	100	0	No	No	Yes	Yes	8	0
23	2x64	Lig	prostanoid_off	100	0	Yes	No	Yes	Yes	6	0
24	E1x50	E1x52	prostanoid_off	100	0	Yes	Yes	No	No	6	5
25	3x28	E1x50	prostanoid_off	100	0	No	No	Yes	Yes	6	6
26	E1x50	E2x50	prostanoid_off	100	0	Yes	Yes	No	No	6	9
27	3x25	E2	prostanoid_off	100	0	No	No	Yes	Yes	9	5
28	3x26	E2	prostanoid_off	100	0	No	No	Yes	Yes	6	5
29	3x27	3x31	prostanoid_off	100	0	No	No	No	No	5	5
30	3x36	5x43	prostanoid_off	100	0	Yes	No	Yes	No	7	7
31	3x37	4x56	prostanoid_off	100	0	Yes	No	Yes	No	8	7
32	3x37	5x43	prostanoid_off	100	0	Yes	No	Yes	No	8	7
33	3x38	4x53	prostanoid_off	100	0	No	No	No	No	8	8
34	3x39	7x45	prostanoid_off	100	0	No	No	Yes	Yes	9	9
35	3x40	5x50	prostanoid_off	100	0	No	No	Yes	No	8	8
36	3x41	4x53	prostanoid_off	100	0	No	No	No	No	7	8
37	3x43	6x41	prostanoid_off	100	0	No	No	No	No	8	8
38	3x43	6x44	prostanoid_off	100	0	No	No	No	No	8	8
39	3x44	5x50	prostanoid_off	100	0	No	No	Yes	No	7	8
40	3x46	6x37	prostanoid_off	100	0	No	No	Yes	No	9	8
41	3x47	5x54	prostanoid_off	100	0	No	No	No	No	9	8
42	3x47	5x57	prostanoid_off	100	0	No	No	No	No	9	7
43	3x49	3x50	prostanoid_off	100	0	Yes	No	Yes	No	9	9
44	3x49	4x38	prostanoid_off	100	0	Yes	No	Yes	No	9	8
45	3x50	4x38	prostanoid_off	100	0	Yes	No	Yes	No	9	8
46	3x50	6x33	prostanoid_off	100	0	Yes	No	Yes	No	9	9
47	3x51	5x57	prostanoid_off	100	0	Yes	No	No	No	8	7
48	3x54	5x61	prostanoid_off	100	0	Yes	No	No	No	9	9
49	4x38	I2x53	prostanoid_off	100	0	Yes	No	No	Yes	8	8
50	4x40	I2x56	prostanoid_off	100	0	No	No	Yes	No	5	5
51	4x41	I2x56	prostanoid_off	100	0	No	No	Yes	No	5	5
52	4x56	5x42	prostanoid_off	100	0	Yes	No	No	No	7	5
53	4x56	5x46	prostanoid_off	100	0	Yes	No	No	No	7	6
54	4x59	E2	prostanoid_off	100	0	No	No	Yes	Yes	8	5
55	5x39	E2	prostanoid_off	100	0	No	No	Yes	Yes	8	5
56	6x51	E2x51	prostanoid_off	100	0	Yes	No	Yes	Yes	7	6
57	5x40	6x59	prostanoid_off	100	0	No	No	No	No	7	6
58	5x44	6x52	prostanoid_off	100	0	Yes	No	Yes	No	7	7
59	5x46	5x50	prostanoid_off	100	0	No	No	Yes	No	6	8
60	5x47	6x52	prostanoid_off	100	0	No	No	Yes	No	7	7
61	5x51	6x45	prostanoid_off	100	0	No	No	No	No	7	6
62	5x54	6x41	prostanoid_off	100	0	No	No	No	No	8	8
63	6x36	7x53	prostanoid_off	100	0	No	No	Yes	Yes	8	9
64	6x36	7x56	prostanoid_off	100	0	No	No	No	No	8	8
65	6x37	6x41	prostanoid_off	100	0	Yes	No	No	No	8	8
66	6x40	7x52	prostanoid_off	100	0	No	No	No	No	8	8
67	6x43	7x52	prostanoid_off	100	0	No	No	No	No	6	8
68	6x44	6x48	prostanoid_off	100	0	No	No	Yes	Yes	8	8
69	6x47	7x40	prostanoid_off	100	0	No	No	No	No	9	8
70	6x54	6x57	prostanoid_off	100	0	Yes	Yes	No	No	6	5
71	6x58	7x34	prostanoid_off	100	0	Yes	No	Yes	No	6	6
72	7x32	7x35	prostanoid_off	100	0	No	No	No	No	2	6
73	7x35	Lig	prostanoid_off	100	0	No	No	Yes	Yes	6	0
74	7x56	8x51	prostanoid_off	100	0	No	No	No	No	8	7
75	8x51	8x55	prostanoid_off	100	0	No	No	No	No	7	4
76	1x49	7x50	prostanoid_off	100	0	Yes	No	No	No	9	9
77	5x44	5x47	prostanoid_off	100	0	Yes	No	No	No	7	7
78	2x63	Lig	prostanoid_off	100	0	No	No	Yes	Yes	7	0
79	3x33	Lig	prostanoid_off	100	0	Yes	Yes	Yes	Yes	7	0
80	4x65	Lig	prostanoid_off	100	0	No	No	Yes	Yes	0	0
81	E2x51	Lig	prostanoid_off	100	0	Yes	Yes	Yes	Yes	6	0
82	E2x52	Lig	prostanoid_off	100	0	Yes	Yes	Yes	Yes	7	0
83	6x51	Lig	prostanoid_off	100	0	Yes	No	Yes	Yes	7	0
84	7x31	Lig	prostanoid_off	100	0	Yes	No	Yes	Yes	0	0
85	5x32	NT	prostanoid_off	100	0	No	No	Yes	Yes	0	0
86	7x27	NT	prostanoid_off	100	0	No	No	Yes	Yes	0	0
87	7x31	NT	prostanoid_off	100	0	Yes	No	Yes	Yes	0	0
88	E1x49	NT	prostanoid_off	100	0	No	Yes	Yes	Yes	4	0
89	1x43	2x58	prostanoid_off	100	0	Yes	No	No	No	6	9
90	1x55	1x60	prostanoid_off	100	0	No	No	No	No	5	6
91	8x53	I1	prostanoid_off	100	0	No	No	Yes	No	7	6
92	2x38	I2x57	prostanoid_off	100	0	No	No	Yes	No	6	7
93	2x45	4x46	prostanoid_off	100	0	No	No	No	No	8	8
94	2x45	4x50	prostanoid_off	100	0	No	No	Yes	No	8	8
95	2x56	3x28	prostanoid_off	100	0	No	No	No	No	7	6
96	2x57	7x42	prostanoid_off	100	0	No	Yes	No	No	8	8
97	2x64	E1	prostanoid_off	100	0	Yes	No	No	Yes	6	0
98	E1x49	E2	prostanoid_off	100	0	No	Yes	Yes	Yes	4	5
99	3x25	E1x50	prostanoid_off	100	0	No	No	Yes	Yes	9	6
100	3x22	E2	prostanoid_off	100	0	No	No	Yes	Yes	2	5
101	3x26	4x62	prostanoid_off	100	0	No	No	No	No	6	5
102	3x29	4x65	prostanoid_off	100	0	No	No	No	No	7	0
103	3x30	4x62	prostanoid_off	100	0	No	No	No	No	7	5
104	3x32	3x33	prostanoid_off	100	0	Yes	Yes	Yes	Yes	8	7
105	3x32	6x48	prostanoid_off	100	0	Yes	Yes	Yes	Yes	8	8
106	3x32	6x51	prostanoid_off	100	0	Yes	Yes	Yes	No	8	7
107	3x32	7x42	prostanoid_off	100	0	Yes	Yes	No	No	8	8
108	3x33	4x61	prostanoid_off	100	0	Yes	Yes	No	No	7	5
109	3x36	3x37	prostanoid_off	100	0	Yes	No	Yes	No	7	8
110	3x36	6x48	prostanoid_off	100	0	Yes	No	Yes	Yes	7	8
111	3x49	I2x57	prostanoid_off	100	0	Yes	No	Yes	No	9	7
112	3x50	3x53	prostanoid_off	100	0	Yes	No	No	No	9	9
113	3x50	3x54	prostanoid_off	100	0	Yes	No	Yes	No	9	9
114	3x53	I2x57	prostanoid_off	100	0	No	No	Yes	No	9	7
115	3x55	5x64	prostanoid_off	100	0	No	No	No	No	7	7
116	I2x50	I3	prostanoid_off	100	0	No	No	No	Yes	9	0
117	4x43	4x47	prostanoid_off	100	0	No	No	No	No	5	4
118	4x61	5x43	prostanoid_off	100	0	No	No	Yes	No	5	7
119	4x64	5x35	prostanoid_off	100	0	No	No	Yes	No	0	3
120	4x65	E2x52	prostanoid_off	100	0	No	No	Yes	Yes	0	7
121	6x58	E2x51	prostanoid_off	100	0	Yes	No	Yes	Yes	6	6
122	7x31	E2x51	prostanoid_off	100	0	Yes	No	Yes	Yes	0	6
123	5x36	E2x52	prostanoid_off	100	0	No	No	Yes	Yes	5	7
124	5x32	E2	prostanoid_off	100	0	No	No	Yes	Yes	0	5
125	5x27	5x30	prostanoid_off	100	0	No	No	No	No	0	0
126	5x29	E3	prostanoid_off	100	0	No	No	Yes	Yes	0	2
127	5x31	5x35	prostanoid_off	100	0	No	No	Yes	No	0	3
128	5x33	E3	prostanoid_off	100	0	No	Yes	Yes	Yes	3	2
129	5x43	6x51	prostanoid_off	100	0	Yes	No	Yes	No	7	7
130	5x43	6x52	prostanoid_off	100	0	Yes	No	Yes	No	7	7
131	5x43	6x55	prostanoid_off	100	0	Yes	No	No	No	7	7
132	5x44	5x48	prostanoid_off	100	0	Yes	No	No	No	7	6
133	5x47	5x51	prostanoid_off	100	0	No	No	No	No	7	7
134	5x68	I3	prostanoid_off	100	0	No	No	No	Yes	7	0
135	6x32	6x33	prostanoid_off	100	0	Yes	No	Yes	No	8	9
136	6x33	6x36	prostanoid_off	100	0	Yes	No	No	No	9	8
137	6x35	8x48	prostanoid_off	100	0	No	No	No	Yes	7	6
138	6x51	6x52	prostanoid_off	100	0	Yes	No	Yes	No	7	7
139	6x60	E3	prostanoid_off	100	0	No	No	Yes	Yes	4	2
140	7x31	7x34	prostanoid_off	100	0	Yes	No	Yes	No	0	6
141	7x54	8x51	prostanoid_off	100	0	No	No	No	No	8	7
142	8x47	8x48	prostanoid_off	100	0	Yes	Yes	No	Yes	9	6
143	8x47	8x49	prostanoid_off	100	0	Yes	Yes	No	No	9	7
144	8x49	8x52	prostanoid_off	100	0	No	No	No	No	7	5
145	8x59	8x63	prostanoid_off	100	0	No	No	No	No	4	0
146	1x53	7x53	prostanoid_off	50	0	No	No	Yes	Yes	9	9
147	3x50	6x31	prostanoid_off	50	0	Yes	No	No	No	9	6
148	5x41	6x60	prostanoid_off	50	0	No	No	No	No	5	4
149	1x43	2x61	prostanoid_off	50	0	Yes	No	No	No	6	6
150	1x49	7x47	prostanoid_off	50	0	Yes	No	No	No	9	8
151	2x48	4x50	prostanoid_off	50	0	No	No	Yes	No	5	8
152	1x39	7x43	prostanoid_off	50	0	Yes	No	No	No	7	5
153	2x42	4x42	prostanoid_off	50	0	Yes	Yes	No	No	8	8
154	1x36	2x64	prostanoid_off	50	0	No	No	Yes	No	6	6
155	2x37	6x32	prostanoid_off	50	0	No	No	Yes	No	7	8
156	5x41	6x59	prostanoid_off	50	0	No	No	No	No	5	6
157	6x30	I1	prostanoid_off	50	0	No	No	Yes	No	8	6
158	2x62	2x66	prostanoid_off	50	0	No	No	No	No	6	5
159	3x48	5x57	prostanoid_off	50	0	No	No	No	No	7	7
160	5x56	5x60	prostanoid_off	50	0	No	No	No	No	4	5
161	3x36	5x461	prostanoid_off	50	0	Yes	No	No	No	7	0
162	2x67	NT	prostanoid_off	50	0	No	No	Yes	Yes	4	0
163	5x45	5x48	prostanoid_off	0	0	No	No	No	No	5	6
164	1x32	1x35	prostanoid_off	50	0	No	No	No	No	0	5
165	6x29	6x32	prostanoid_off	50	0	No	No	Yes	No	7	8
166	6x29	I1	prostanoid_off	50	0	No	No	Yes	No	7	6
167	2x66	E1x51	prostanoid_off	0	0	No	No	No	No	5	4
168	1x33	1x34	prostanoid_off	50	0	No	No	No	No	4	1
169	1x57	2x44	prostanoid_off	50	0	No	No	No	No	8	6
170	7x30	7x34	prostanoid_off	50	0	No	No	Yes	No	0	6
171	1x35	2x64	prostanoid_off	0	0	No	No	Yes	No	5	6
172	1x55	1x59	prostanoid_off	50	0	No	No	No	No	5	6
173	5x58	6x37	prostanoid_off	50	0	No	No	Yes	No	9	8
174	7x26	E3	prostanoid_off	50	0	No	No	Yes	Yes	0	2
175	I2x54	I2x55	prostanoid_off	50	0	No	No	No	No	6	5
176	1x43	1x47	prostanoid_off	50	0	Yes	No	No	No	6	7
177	3x54	5x68	prostanoid_off	50	0	Yes	No	No	No	9	7
178	3x23	3x24	prostanoid_off	50	0	No	No	No	No	2	6
179	I2x51	I2x54	prostanoid_off	50	0	No	No	No	No	7	6
180	1x46	2x54	prostanoid_off	50	0	No	No	No	No	8	8
181	1x48	1x49	prostanoid_off	50	0	No	No	Yes	No	5	9
182	1x43	2x55	prostanoid_off	50	0	Yes	No	No	No	6	5
183	5x49	5x50	prostanoid_off	50	0	No	No	Yes	No	4	8
184	3x51	3x52	prostanoid_off	50	0	Yes	No	No	No	8	6
185	4x43	4x46	prostanoid_off	50	0	No	No	No	No	5	8
186	4x59	4x63	prostanoid_off	0	0	No	No	No	No	8	8
187	1x58	I1	prostanoid_off	50	0	No	No	Yes	No	4	6
188	5x61	6x34	prostanoid_off	50	0	No	No	No	No	9	7
189	1x32	1x34	prostanoid_off	50	0	No	No	No	No	0	1
190	1x56	8x53	prostanoid_off	50	0	No	No	No	No	7	7
191	5x48	5x52	prostanoid_off	25	0	No	No	No	No	6	4
192	6x43	7x48	prostanoid_off	25	0	No	No	No	No	6	7
193	4x48	4x52	prostanoid_off	50	0	No	No	No	No	2	5
194	8x58	8x59	prostanoid_off	0	0	No	No	No	No	5	4
195	5x28	NT	prostanoid_off	0	0	No	No	Yes	Yes	0	0
196	6x38	6x42	prostanoid_off	0	0	No	Yes	No	No	7	6
197	4x44	4x47	prostanoid_off	0	0	No	No	No	No	4	4
198	8x58	8x62	prostanoid_off	0	0	No	No	No	No	5	0
199	5x34	5x35	prostanoid_off	0	0	No	No	Yes	No	4	3
200	5x68	5x69	prostanoid_off	0	0	No	No	No	No	7	5
201	7x36	7x37	prostanoid_off	0	0	No	No	No	No	3	7
202	6x39	7x56	prostanoid_off	0	0	No	No	No	No	6	8
203	3x21	E1x52	prostanoid_off	0	0	No	No	No	No	5	5
204	7x28	E3	prostanoid_off	0	0	No	No	Yes	Yes	0	2
205	5x62	5x63	prostanoid_off	0	0	No	No	No	No	7	3
206	6x46	6x47	prostanoid_off	0	0	No	No	No	No	7	9
207	1x56	8x57	prostanoid_off	0	0	No	No	No	No	7	4
208	2x38	4x39	prostanoid_off	0	0	No	No	No	No	6	5
209	1x52	7x54	prostanoid_off	0	0	No	No	No	No	6	8
210	5x51	5x55	prostanoid_off	0	0	No	No	No	Yes	7	6
211	4x52	4x55	prostanoid_off	0	0	No	No	No	No	5	4
212	5x27	5x29	prostanoid_off	0	0	No	No	No	No	0	0
213	6x54	7x29	prostanoid_off	0	0	Yes	Yes	No	No	6	0
214	1x36	2x65	Shared	100	100	No	No	No	No	6	4
215	1x45	7x47	Shared	100	50	No	No	No	No	5	8
216	1x50	2x47	Shared	100	100	Yes	Yes	No	No	9	8
217	1x50	2x50	Shared	100	100	Yes	Yes	Yes	Yes	9	9
218	1x50	2x51	Shared	100	100	Yes	Yes	No	Yes	9	8
219	1x50	7x50	Shared	100	100	Yes	Yes	No	No	9	9
220	I1	I1	Shared	100	100	Yes	No	Yes	No	6	6
221	2x39	3x46	Shared	100	100	Yes	Yes	No	No	8	9
222	2x39	3x50	Shared	100	100	Yes	Yes	Yes	No	8	9
223	2x42	3x46	Shared	100	100	Yes	Yes	No	No	8	9
224	2x42	4x46	Shared	100	50	Yes	Yes	No	No	8	8
225	2x46	3x42	Shared	100	100	No	No	No	No	9	8
226	2x49	2x50	Shared	100	33.3333	No	No	Yes	Yes	9	9
227	2x49	4x50	Shared	100	100	No	No	Yes	No	9	8
228	2x50	3x39	Shared	100	100	Yes	Yes	No	No	9	9
229	2x50	7x46	Shared	100	100	Yes	Yes	No	Yes	9	9
230	2x53	3x35	Shared	100	100	No	No	Yes	No	8	7
231	2x54	7x46	Shared	100	100	No	No	No	Yes	8	9
232	2x56	3x31	Shared	100	100	No	No	No	No	7	5
233	3x24	E1x50	Shared	100	100	No	No	Yes	Yes	6	6
234	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
235	3x29	E2	Shared	100	100	No	No	Yes	Yes	7	5
236	3x30	4x61	Shared	100	50	No	No	No	No	7	5
237	3x32	E2x51	Shared	100	100	Yes	Yes	Yes	Yes	8	6
238	3x32	Lig	Shared	100	100	Yes	Yes	Yes	Yes	8	0
239	3x33	4x57	Shared	100	50	Yes	Yes	No	No	7	8
240	3x33	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	7	7
241	3x33	5x43	Shared	100	50	Yes	Yes	Yes	No	7	7
242	3x34	3x35	Shared	100	100	Yes	Yes	Yes	No	7	7
243	3x34	3x38	Shared	100	100	Yes	Yes	No	No	7	8
244	3x34	4x50	Shared	100	100	Yes	Yes	Yes	No	7	8
245	3x34	4x54	Shared	100	100	Yes	Yes	No	No	7	4
246	3x37	5x46	Shared	100	50	Yes	No	No	No	8	6
247	3x39	7x46	Shared	100	100	No	No	No	Yes	9	9
248	3x41	4x49	Shared	100	100	No	No	No	No	7	7
249	3x51	3x55	Shared	100	100	Yes	No	No	No	8	7
250	3x51	5x60	Shared	100	100	Yes	No	No	No	8	5
251	3x55	3x56	Shared	100	50	No	No	No	Yes	7	7
252	3x56	I2x52	Shared	100	100	No	Yes	No	No	7	5
253	I2x53	I2x57	Shared	100	50	No	Yes	Yes	No	8	7
254	I2x55	I2x56	Shared	100	50	No	No	Yes	No	5	5
255	4x59	4x60	Shared	100	50	No	No	No	No	8	9
256	4x60	5x39	Shared	100	100	No	No	No	No	9	8
257	5x36	E2	Shared	100	100	No	No	Yes	Yes	5	5
258	E2	E2x50	Shared	100	100	Yes	Yes	No	No	5	9
259	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	5	5
260	E2	E2x51	Shared	100	100	Yes	Yes	Yes	Yes	5	6
261	E2	E3	Shared	100	100	Yes	Yes	Yes	Yes	5	2
262	E2	Lig	Shared	100	100	Yes	Yes	Yes	Yes	5	0
263	7x34	E2	Shared	100	100	Yes	No	Yes	Yes	6	5
264	7x38	E2	Shared	100	100	No	No	Yes	Yes	6	5
265	E2x51	E2x52	Shared	100	100	Yes	Yes	Yes	Yes	6	7
266	6x58	E2	Shared	100	100	Yes	No	Yes	Yes	6	5
267	5x37	6x59	Shared	100	0	No	No	No	No	5	6
268	5x44	6x56	Shared	100	0	Yes	No	No	No	7	6
269	6x32	8x48	Shared	100	100	Yes	No	No	Yes	8	6
270	6x40	7x53	Shared	100	100	No	No	Yes	Yes	8	9
271	6x47	7x45	Shared	100	100	No	No	Yes	Yes	9	9
272	6x49	6x50	Shared	100	50	No	No	No	No	7	9
273	6x50	7x40	Shared	100	50	No	No	No	No	9	8
274	6x54	6x58	Shared	100	100	Yes	Yes	Yes	No	6	6
275	6x54	7x33	Shared	100	100	Yes	Yes	No	No	6	4
276	6x54	7x34	Shared	100	100	Yes	Yes	Yes	No	6	6
277	6x54	7x37	Shared	100	100	Yes	Yes	No	No	6	7
278	6x60	6x61	Shared	100	50	No	No	No	No	4	4
279	E3	E3	Shared	100	100	Yes	Yes	Yes	Yes	2	2
280	7x38	Lig	Shared	100	100	No	No	Yes	Yes	6	0
281	7x39	Lig	Shared	100	100	No	No	Yes	Yes	7	0
282	7x42	Lig	Shared	100	100	No	No	Yes	Yes	8	0
283	7x45	7x49	Shared	100	100	Yes	Yes	No	No	9	9
284	8x47	8x50	Shared	100	50	Yes	Yes	No	No	9	7
285	NT	NT	Shared	100	100	Yes	Yes	Yes	Yes	0	0
286	E2	NT	Shared	100	100	Yes	Yes	Yes	Yes	5	0
287	E3	NT	Shared	100	100	Yes	Yes	Yes	Yes	2	0
288	2x37	2x40	Shared	100	50	No	No	No	Yes	7	8
289	E1x49	E1x51	Shared	100	0	No	Yes	No	No	4	4
290	3x37	3x41	Shared	100	66.6667	Yes	No	No	No	8	7
291	I2x52	I2x56	Shared	100	100	No	No	Yes	No	5	5
292	5x35	E2	Shared	100	50	Yes	No	Yes	Yes	3	5
293	6x33	8x47	Shared	100	100	Yes	No	Yes	Yes	9	9
294	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	8
295	6x48	7x45	Shared	100	100	Yes	Yes	Yes	Yes	8	9
296	7x49	7x53	Shared	100	100	No	No	Yes	Yes	9	9
297	1x54	2x48	Shared	50	16.6667	No	No	No	No	8	5
298	1x51	2x51	Shared	50	100	No	No	No	Yes	5	8
299	3x54	5x65	Shared	50	50	Yes	No	No	No	9	9
300	1x49	7x51	Shared	50	100	Yes	No	No	No	9	7
301	5x58	6x38	Shared	50	50	No	No	No	Yes	9	7
302	3x44	5x53	Shared	50	50	No	No	No	Yes	7	6
303	2x42	4x45	Shared	50	50	Yes	Yes	No	No	8	7
304	1x41	1x45	Shared	50	0	No	No	No	No	5	5
305	2x42	3x45	Shared	50	0	Yes	Yes	No	No	8	8
306	1x40	1x43	Shared	50	16.6667	No	No	Yes	No	5	6
307	2x41	4x42	Shared	50	50	No	Yes	No	No	6	8
308	6x53	6x57	Shared	0	66.6667	No	No	No	No	7	5
309	1x44	1x48	Shared	0	16.6667	No	No	No	No	5	5
310	1x56	8x54	Shared	50	50	No	No	No	No	7	5
311	7x51	7x55	Shared	50	100	No	No	No	No	7	6
312	4x55	4x56	Shared	0	16.6667	No	No	Yes	No	4	7
313	8x53	8x56	Shared	0	0	No	No	No	No	7	4
314	3x30	4x58	Shared	0	100	No	No	No	No	7	6
315	5x62	6x38	Shared	0	50	No	No	No	Yes	7	7
316	5x55	5x59	Shared	0	0	No	Yes	No	No	6	4
317	3x22	NT	prostanoid_on	0	100	No	No	Yes	Yes	2	0
318	7x28	NT	prostanoid_on	0	100	No	No	Yes	Yes	0	0
319	7x32	NT	prostanoid_on	0	100	No	No	Yes	Yes	2	0
320	1x36	NT	prostanoid_on	0	100	No	No	Yes	Yes	6	0
321	1x36	1x37	prostanoid_on	0	100	No	No	No	No	6	5
322	1x38	7x39	prostanoid_on	0	100	No	No	No	No	6	7
323	1x39	Lig	prostanoid_on	0	100	Yes	No	Yes	Yes	7	0
324	1x42	7x42	prostanoid_on	0	100	No	No	No	No	8	8
325	1x42	7x43	prostanoid_on	0	100	No	No	No	No	8	5
326	1x43	Lig	prostanoid_on	0	100	Yes	No	Yes	Yes	6	0
327	1x46	7x47	prostanoid_on	0	100	No	No	No	No	8	8
328	1x47	2x51	prostanoid_on	0	100	No	No	No	Yes	7	8
329	1x54	2x47	prostanoid_on	0	100	No	No	No	No	8	8
330	1x56	8x50	prostanoid_on	0	100	No	No	No	No	7	7
331	1x57	2x43	prostanoid_on	0	100	No	No	No	No	8	8
332	2x38	2x42	prostanoid_on	0	100	No	No	Yes	Yes	6	8
333	2x38	3x49	prostanoid_on	0	100	No	No	Yes	No	6	9
334	2x38	4x42	prostanoid_on	0	100	No	No	No	No	6	8
335	2x41	4x43	prostanoid_on	0	100	No	Yes	No	No	6	5
336	2x43	7x54	prostanoid_on	0	100	No	No	No	No	8	8
337	2x46	2x50	prostanoid_on	0	100	No	No	Yes	Yes	9	9
338	2x46	7x49	prostanoid_on	0	100	No	No	No	No	9	9
339	2x49	3x38	prostanoid_on	0	100	No	No	No	No	9	8
340	2x51	2x52	prostanoid_on	0	100	No	Yes	No	No	8	7
341	2x54	Lig	prostanoid_on	0	100	No	No	Yes	Yes	8	0
342	2x57	3x28	prostanoid_on	0	100	No	Yes	No	No	8	6
343	2x57	3x32	prostanoid_on	0	100	No	Yes	Yes	Yes	8	8
344	2x57	Lig	prostanoid_on	0	100	No	Yes	Yes	Yes	8	0
345	2x60	3x28	prostanoid_on	0	100	No	No	No	No	8	6
346	2x61	Lig	prostanoid_on	0	100	No	No	Yes	Yes	6	0
347	2x64	E1x50	prostanoid_on	0	100	Yes	No	Yes	Yes	6	6
348	2x65	E2	prostanoid_on	0	100	No	No	Yes	Yes	4	5
349	2x65	Lig	prostanoid_on	0	100	No	No	Yes	Yes	4	0
350	E1	E1x52	prostanoid_on	0	100	No	Yes	No	No	0	5
351	E1x50	E2	prostanoid_on	0	100	Yes	Yes	Yes	Yes	6	5
352	3x24	E1	prostanoid_on	0	100	No	No	No	Yes	6	0
353	3x26	4x61	prostanoid_on	0	100	No	No	No	No	6	5
354	3x28	3x32	prostanoid_on	0	100	No	No	Yes	Yes	6	8
355	3x33	E2	prostanoid_on	0	100	Yes	Yes	Yes	Yes	7	5
356	3x33	E2x51	prostanoid_on	0	100	Yes	Yes	Yes	Yes	7	6
357	3x36	Lig	prostanoid_on	0	100	Yes	No	Yes	Yes	7	0
358	3x40	6x48	prostanoid_on	0	100	No	No	Yes	Yes	8	8
359	3x42	4x49	prostanoid_on	0	100	No	No	No	No	8	7
360	3x46	7x53	prostanoid_on	0	100	No	No	Yes	Yes	9	9
361	3x49	I2x53	prostanoid_on	0	100	Yes	No	No	Yes	9	8
362	3x50	6x37	prostanoid_on	0	100	Yes	No	Yes	No	9	8
363	3x52	I2x53	prostanoid_on	0	100	No	No	No	Yes	6	8
364	4x38	4x41	prostanoid_on	0	100	Yes	No	No	No	8	5
365	4x40	4x41	prostanoid_on	0	100	No	No	No	No	5	5
366	4x60	E2	prostanoid_on	0	100	No	No	Yes	Yes	9	5
367	5x33	E2	prostanoid_on	0	100	No	Yes	Yes	Yes	3	5
368	7x28	E2	prostanoid_on	0	100	No	No	Yes	Yes	0	5
369	7x31	E2	prostanoid_on	0	100	Yes	No	Yes	Yes	0	5
370	7x35	E2	prostanoid_on	0	100	No	No	Yes	Yes	6	5
371	E2	E2x52	prostanoid_on	0	100	Yes	Yes	Yes	Yes	5	7
372	5x39	E2x52	prostanoid_on	0	100	No	No	Yes	Yes	8	7
373	5x33	5x36	prostanoid_on	0	100	No	Yes	No	No	3	5
374	5x55	6x42	prostanoid_on	0	100	No	Yes	No	No	6	6
375	5x68	6x31	prostanoid_on	0	100	No	No	No	No	7	6
376	5x69	6x28	prostanoid_on	0	100	No	No	No	No	5	5
377	6x26	6x31	prostanoid_on	0	100	No	No	No	No	0	6
378	6x33	8x48	prostanoid_on	0	100	Yes	No	No	Yes	9	6
379	6x34	6x38	prostanoid_on	0	100	No	No	No	Yes	7	7
380	6x37	8x47	prostanoid_on	0	100	Yes	No	Yes	Yes	8	9
381	6x41	7x53	prostanoid_on	0	100	No	No	Yes	Yes	8	9
382	6x44	7x48	prostanoid_on	0	100	No	No	No	No	8	7
383	6x48	7x46	prostanoid_on	0	100	Yes	Yes	No	Yes	8	9
384	6x48	Lig	prostanoid_on	0	100	Yes	Yes	Yes	Yes	8	0
385	6x51	6x55	prostanoid_on	0	100	Yes	No	No	No	7	7
386	7x35	7x39	prostanoid_on	0	100	No	No	No	No	6	7
387	7x43	7x47	prostanoid_on	0	100	No	No	No	No	5	8
388	7x43	7x48	prostanoid_on	0	100	No	No	No	No	5	7
389	7x45	7x46	prostanoid_on	0	100	Yes	Yes	No	Yes	9	9
390	7x46	Lig	prostanoid_on	0	100	No	Yes	Yes	Yes	9	0
391	7x51	7x56	prostanoid_on	0	100	No	No	No	No	7	8
392	8x48	8x51	prostanoid_on	0	100	No	Yes	No	No	6	7
393	1x57	7x54	prostanoid_on	0	100	No	No	No	No	8	8
394	1x61	1x65	prostanoid_on	0	100	No	No	No	No	0	0
395	1x61	2x41	prostanoid_on	0	100	No	No	No	Yes	0	6
396	2x63	E1	prostanoid_on	0	100	No	No	No	Yes	7	0
397	2x67	E1x52	prostanoid_on	0	100	No	No	No	No	4	5
398	E1	E1x50	prostanoid_on	0	100	No	Yes	Yes	Yes	0	6
399	4x52	4x56	prostanoid_on	0	100	No	No	Yes	No	5	7
400	5x34	E2	prostanoid_on	0	100	No	No	Yes	Yes	4	5
401	5x31	5x33	prostanoid_on	0	100	No	No	No	Yes	0	3
402	5x32	5x33	prostanoid_on	0	100	No	No	No	Yes	0	3
403	5x61	5x65	prostanoid_on	0	100	No	No	No	No	9	9
404	5x67	6x27	prostanoid_on	0	100	No	No	No	No	4	6
405	5x67	6x30	prostanoid_on	0	100	No	No	No	No	4	8
406	6x32	8x47	prostanoid_on	0	100	Yes	No	Yes	Yes	8	9
407	6x36	8x47	prostanoid_on	0	100	No	No	Yes	Yes	8	9
408	6x57	6x61	prostanoid_on	0	100	No	No	No	No	5	4
409	7x33	E3	prostanoid_on	0	100	No	No	Yes	Yes	4	2
410	3x37	5x41	prostanoid_on	0	50	Yes	No	No	No	8	5
411	3x52	3x56	prostanoid_on	0	50	No	No	No	Yes	6	7
412	6x51	7x37	prostanoid_on	0	50	Yes	No	No	No	7	7
413	5x46	6x52	prostanoid_on	0	50	No	No	Yes	No	6	7
414	6x61	E3	prostanoid_on	0	50	No	No	Yes	Yes	4	2
415	4x61	E2	prostanoid_on	0	50	No	No	Yes	Yes	5	5
416	7x52	7x56	prostanoid_on	0	83.3333	No	No	No	No	8	8
417	3x53	I2x53	prostanoid_on	0	50	No	No	No	Yes	9	8
418	2x41	4x39	prostanoid_on	0	50	No	Yes	No	No	6	5
419	2x39	2x43	prostanoid_on	0	50	Yes	Yes	No	No	8	8
420	1x53	7x55	prostanoid_on	0	50	No	No	No	No	9	6
421	5x54	5x58	prostanoid_on	0	50	No	No	No	No	8	9
422	6x31	6x35	prostanoid_on	0	50	No	No	No	No	6	7
423	5x53	6x41	prostanoid_on	0	50	No	Yes	No	No	6	8
424	7x56	8x47	prostanoid_on	0	0	No	No	Yes	Yes	8	9
425	5x56	6x41	prostanoid_on	0	50	No	No	No	No	4	8
426	3x34	4x53	prostanoid_on	0	16.6667	Yes	Yes	No	No	7	8
427	5x53	5x57	prostanoid_on	0	50	No	Yes	No	No	6	7
428	1x52	7x55	prostanoid_on	0	16.6667	No	No	No	No	6	6
429	2x58	Lig	prostanoid_on	0	33.3333	No	No	Yes	Yes	9	0
430	5x70	I3	prostanoid_on	0	50	No	No	No	Yes	0	0
431	5x64	5x68	prostanoid_on	0	50	No	No	No	No	7	7
432	2x44	2x48	prostanoid_on	0	16.6667	No	No	No	No	6	5
433	5x72	I3	prostanoid_on	0	50	No	No	No	Yes	0	0
434	5x69	6x32	prostanoid_on	0	50	No	No	Yes	No	5	8
435	E1x49	E1x52	prostanoid_on	0	50	No	Yes	No	No	4	5
436	5x37	E2x52	prostanoid_on	0	50	No	No	Yes	Yes	5	7
437	E1x49	E1x501	prostanoid_on	0	50	No	Yes	No	No	4	0
438	4x56	5x39	prostanoid_on	0	50	Yes	No	No	No	7	8
439	4x52	5x44	prostanoid_on	0	50	No	No	Yes	No	5	7
440	3x50	6x38	prostanoid_on	0	50	Yes	No	No	Yes	9	7
441	5x66	6x35	prostanoid_on	0	50	No	No	No	No	6	7
442	7x27	7x30	prostanoid_on	0	50	No	No	No	No	0	0
443	3x54	5x59	prostanoid_on	0	50	Yes	No	No	No	9	4
444	2x57	3x31	prostanoid_on	0	16.6667	No	Yes	No	No	8	5
445	5x38	E2x52	prostanoid_on	0	50	No	No	Yes	Yes	5	7
446	1x47	2x55	prostanoid_on	0	0	No	No	No	No	7	5
447	5x40	5x44	prostanoid_on	0	50	No	No	Yes	No	7	7
448	3x41	5x50	prostanoid_on	0	50	No	No	Yes	No	7	8
449	5x51	6x49	prostanoid_on	0	50	No	No	No	No	7	7
450	5x52	5x56	prostanoid_on	0	50	No	No	No	No	4	4
451	2x44	2x45	prostanoid_on	0	16.6667	No	No	No	No	6	8
452	1x54	1x58	prostanoid_on	0	50	No	No	No	No	8	4
453	3x23	E1	prostanoid_on	0	50	No	No	No	Yes	2	0
454	5x65	6x35	prostanoid_on	0	50	No	No	No	No	9	7
455	3x47	5x56	prostanoid_on	0	50	No	No	No	No	9	4
456	7x36	7x40	prostanoid_on	0	50	No	No	No	No	3	8
457	8x56	8x60	prostanoid_on	0	50	No	No	No	No	4	6
458	5x43	5x47	prostanoid_on	0	50	Yes	No	No	No	7	7
459	1x35	1x38	prostanoid_on	0	50	No	No	No	No	5	6
460	5x55	6x46	prostanoid_on	0	50	No	Yes	No	No	6	7
461	3x51	5x61	prostanoid_on	0	0	Yes	No	No	No	8	9
462	1x64	2x40	prostanoid_on	0	50	No	No	No	Yes	0	8
463	1x63	1x64	prostanoid_on	0	50	No	No	No	No	0	0
464	5x42	6x56	prostanoid_on	0	50	No	No	No	No	5	6
465	4x40	4x44	prostanoid_on	0	50	No	No	No	No	5	4
466	3x48	5x55	prostanoid_on	0	50	No	No	No	Yes	7	6
467	6x28	6x29	prostanoid_on	0	50	No	No	No	No	5	7
468	3x44	5x51	prostanoid_on	0	50	No	No	No	No	7	7
469	7x27	7x29	prostanoid_on	0	0	No	No	No	No	0	0
470	5x53	6x45	prostanoid_on	0	50	No	Yes	No	No	6	6
471	1x60	2x40	prostanoid_on	0	50	No	No	No	Yes	6	8
472	3x56	I2x50	prostanoid_on	0	0	No	Yes	No	No	7	9
473	2x60	3x27	prostanoid_on	0	0	No	No	No	No	8	5
474	5x63	6x34	prostanoid_on	0	33.3333	No	No	No	No	3	7
475	I1	I2x57	prostanoid_on	0	16.6667	Yes	No	Yes	No	6	7
476	I2x53	I2x54	prostanoid_on	0	0	No	Yes	No	No	8	6
477	5x45	6x52	prostanoid_on	0	16.6667	No	No	Yes	No	5	7
478	2x39	2x40	prostanoid_on	0	0	Yes	Yes	No	Yes	8	8
479	6x39	6x42	prostanoid_on	0	0	No	No	No	No	6	6
480	7x30	7x32	prostanoid_on	0	16.6667	No	No	No	No	0	2
481	6x28	I3	prostanoid_on	0	0	No	No	No	Yes	5	0
482	5x49	5x53	prostanoid_on	0	16.6667	No	No	No	Yes	4	6
483	1x40	2x62	prostanoid_on	0	0	No	No	No	No	5	6
484	1x58	1x62	prostanoid_on	0	16.6667	No	No	No	No	4	0
485	6x25	6x26	prostanoid_on	0	0	No	No	No	No	0	0
486	5x63	6x30	prostanoid_on	0	16.6667	No	No	No	No	3	8
487	5x47	5x48	prostanoid_on	0	0	No	No	No	No	7	6
488	1x58	1x59	prostanoid_on	0	0	No	No	No	No	4	6
489	1x65	1x66	prostanoid_on	0	0	No	No	No	No	0	0
490	3x43	7x53	prostanoid_on	0	0	No	No	Yes	Yes	8	9
491	1x59	8x53	prostanoid_on	0	16.6667	No	No	No	No	6	7
492	4x47	4x48	prostanoid_on	0	0	No	No	No	No	4	2
493	2x68	E1x49	prostanoid_on	0	0	No	No	No	Yes	0	4
494	4x48	4x51	prostanoid_on	0	0	No	No	No	No	2	4
495	6x43	6x47	prostanoid_on	0	0	No	No	No	No	6	9
496	8x55	8x59	prostanoid_on	0	16.6667	No	No	No	No	4	4
497	6x43	6x461	prostanoid_on	0	0	No	No	No	No	6	0
498	4x63	E2	prostanoid_on	0	0	No	No	Yes	Yes	8	5
499	2x59	2x60	prostanoid_on	0	0	No	No	No	No	7	8
500	8x48	8x52	prostanoid_on	0	0	No	Yes	No	No	6	5
501	8x52	8x55	prostanoid_on	0	0	No	No	No	No	5	4
502	1x44	1x45	prostanoid_on	0	0	No	No	No	No	5	5
503	I2x51	I2x52	prostanoid_on	0	0	No	No	No	No	7	5
504	8x61	8x62	prostanoid_on	0	0	No	No	No	No	0	0
505	8x57	8x58	prostanoid_on	0	0	No	No	No	No	4	5
506	8x49	8x53	prostanoid_on	0	0	No	No	No	No	7	7
507	1x59	8x57	prostanoid_on	0	0	No	No	No	No	6	4
508	5x71	I3	prostanoid_on	0	0	No	No	No	Yes	0	0
509	4x55	4x62	prostanoid_on	0	0	No	No	No	No	4	5

Orange: nodes, hubs and links specific of prostanoid_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of prostanoid_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	prostanoid_off Avg Int. Strength	prostanoid_on Avg Int. Strength	prostanoid_off Num Of Links	prostanoid_on Num Of Links	ConSurf
1	1x39	prostanoid_off	100	0	4	1	7
2	1x43	prostanoid_off	50	0	6	2	6
3	1x49	prostanoid_off	0	0	4	1	9
4	I1	prostanoid_off	50	0	7	3	6
5	2x64	prostanoid_off	50	0	6	1	6
6	3x35	prostanoid_off	100	0	4	2	7
7	3x36	prostanoid_off	50	0	4	1	7
8	3x37	prostanoid_off	75	0	5	3	8
9	3x49	prostanoid_off	0	0	4	2	9
10	3x50	prostanoid_off	50	0	7	3	9
11	3x51	prostanoid_off	0	0	4	3	8
12	3x54	prostanoid_off	50	0	4	2	9
13	I2x56	prostanoid_off	0	0	4	2	5
14	I2x57	prostanoid_off	0	0	4	2	7
15	4x38	prostanoid_off	50	0	4	1	8
16	4x50	prostanoid_off	0	0	4	2	8
17	4x56	prostanoid_off	0	0	4	3	7
18	5x35	prostanoid_off	0	0	4	1	3
19	5x43	prostanoid_off	50	0	7	2	7
20	5x44	prostanoid_off	50	0	4	3	7
21	5x50	prostanoid_off	0	0	4	1	8
22	6x32	prostanoid_off	0	0	4	3	8
23	6x33	prostanoid_off	50	0	5	2	9
24	6x37	prostanoid_off	0	0	4	2	8
25	6x51	prostanoid_off	50	0	5	2	7
26	6x52	prostanoid_off	50	0	4	2	7
27	6x58	prostanoid_off	50	0	4	2	6
28	7x34	prostanoid_off	50	0	5	2	6
29	7x31	prostanoid_off	50	0	4	1	0
30	1x50	Shared	0	0	4	4	9
31	2x39	Shared	50	0	4	4	8
32	2x42	Shared	50	50	6	5	8
33	2x50	Shared	50	50	5	5	9
34	E1x50	Shared	100	0	5	4	6
35	3x32	Shared	50	33.3333	6	4	8
36	3x33	Shared	100	33.3333	6	5	7
37	3x34	Shared	50	50	4	5	7
38	E2	Shared	100	100	20	25	5
39	E2x51	Shared	100	50	7	4	6
40	E2x52	Shared	50	50	5	6	7
41	6x48	Shared	50	83.3333	5	5	8
42	6x54	Shared	50	50	6	4	6
43	E3	Shared	100	83.3333	9	6	2
44	7x45	Shared	0	66.6667	4	4	9
45	7x53	Shared	50	50	5	5	9
46	8x47	Shared	50	0	4	6	9
47	Lig	Shared	100	100	15	15	0
48	NT	Shared	50	50	10	8	0
49	2x40	prostanoid_on	0	0	2	4	8
50	2x41	prostanoid_on	0	0	1	4	6
51	2x51	prostanoid_on	0	0	2	4	8
52	2x57	prostanoid_on	0	0	3	4	8
53	E1	prostanoid_on	0	100	1	5	0
54	E1x49	prostanoid_on	0	0	3	4	4
55	3x56	prostanoid_on	0	0	2	4	7
56	I2x53	prostanoid_on	50	0	2	5	8
57	5x33	prostanoid_on	0	0	1	4	3
58	5x53	prostanoid_on	0	0	1	5	6
59	5x55	prostanoid_on	0	0	2	4	6
60	I3	prostanoid_on	0	0	2	4	0
61	6x38	prostanoid_on	0	50	3	4	7
62	7x46	prostanoid_on	0	83.3333	3	6	9
63	8x48	prostanoid_on	0	0	3	4	6

Orange: nodes, hubs and links specific of prostanoid_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of prostanoid_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	prostanoid_off Recurrence	prostanoid_on Recurrence	prostanoid_off Hub1?	prostanoid_on Hub1?	prostanoid_off Hub2?	prostanoid_on Hub2?	ConSurf1	ConSurf2
1	2x64	Lig	prostanoid_off	10.4337	0	Yes	No	Yes	Yes	6	0
2	3x32	Lig	prostanoid_off	45.8862	6.20528	Yes	Yes	Yes	Yes	8	0
3	3x32	6x48	prostanoid_off	100	0	Yes	Yes	Yes	Yes	8	8
4	3x39	7x45	prostanoid_off	22.7405	0	No	No	Yes	Yes	9	9
5	2x50	3x39	prostanoid_off	19.8296	0.487293	Yes	Yes	No	No	9	9
6	1x50	7x50	prostanoid_off	19.6243	0.891315	Yes	Yes	No	No	9	9
7	1x49	7x50	prostanoid_off	17.8677	0	Yes	No	No	No	9	9
8	2x50	7x49	prostanoid_off	25.3101	0	Yes	Yes	No	No	9	9
9	6x36	7x53	prostanoid_off	38.3994	0	No	No	Yes	Yes	8	9
10	6x33	6x36	prostanoid_off	34.4785	0	Yes	No	No	No	9	8
11	6x32	6x33	prostanoid_off	18.2368	0	Yes	No	Yes	No	8	9
12	6x29	6x32	prostanoid_off	11.6602	0	No	No	Yes	No	7	8
13	6x29	I1	prostanoid_off	10.8777	0	No	No	Yes	No	7	6
14	6x44	6x48	prostanoid_off	40.1032	0	No	No	Yes	Yes	8	8
15	3x43	6x44	prostanoid_off	39.44	0	No	No	No	No	8	8
16	3x43	6x41	prostanoid_off	37.5919	0	No	No	No	No	8	8
17	6x37	6x41	prostanoid_off	27.0028	0	Yes	No	No	No	8	8
18	2x39	6x37	prostanoid_off	15.5146	0	Yes	Yes	Yes	No	8	8
19	3x50	6x33	prostanoid_off	14.8958	0	Yes	No	Yes	No	9	9
20	2x49	4x50	prostanoid_off	12.1819	5.16284	No	No	Yes	No	9	8
21	2x45	4x50	prostanoid_off	10.8833	0	No	No	Yes	No	8	8
22	3x25	E2	prostanoid_off	17.002	0	No	No	Yes	Yes	9	5
23	3x25	E1x50	prostanoid_off	15.7616	0	No	No	Yes	Yes	9	6
24	3x28	E1x50	prostanoid_off	15.387	0	No	No	Yes	Yes	6	6
25	E2	E2x50	prostanoid_off	16.7911	2.2946	Yes	Yes	No	No	5	9
26	E1x50	E2x50	prostanoid_off	15.4563	0	Yes	Yes	No	No	6	9
27	5x43	6x51	prostanoid_off	10.7445	0	Yes	No	Yes	No	7	7
28	3x37	5x43	prostanoid_off	16.4054	0	Yes	No	Yes	No	8	7
29	3x36	6x48	prostanoid_off	16.0058	0	Yes	No	Yes	Yes	7	8
30	5x54	6x41	prostanoid_off	19.2497	0	No	No	No	No	8	8
31	3x47	5x54	prostanoid_off	18.2118	0	No	No	No	No	9	8
32	3x47	5x57	prostanoid_off	17.1685	0	No	No	No	No	9	7
33	3x51	5x57	prostanoid_off	15.0651	0	Yes	No	No	No	8	7
34	3x50	3x54	prostanoid_off	11.5492	0	Yes	No	Yes	No	9	9
35	E2	E3	prostanoid_off	18.5809	7.00099	Yes	Yes	Yes	Yes	5	2
36	6x51	6x52	prostanoid_off	10.7112	0	Yes	No	Yes	No	7	7
37	3x32	E2x51	prostanoid_off	40.1254	1.93684	Yes	Yes	Yes	Yes	8	6
38	E2	E2x51	prostanoid_off	35.9908	1.59141	Yes	Yes	Yes	Yes	5	6
39	6x48	7x45	Shared	81.0362	43.2118	Yes	Yes	Yes	Yes	8	9
40	1x50	2x50	Shared	26.5949	16.6821	Yes	Yes	Yes	Yes	9	9
41	7x45	7x49	Shared	56.6335	84.9803	Yes	Yes	No	No	9	9
42	7x49	7x53	Shared	42.2066	100	No	No	Yes	Yes	9	9
43	2x39	3x50	Shared	11.6741	45.2196	Yes	Yes	Yes	No	8	9
44	2x49	2x50	Shared	19.2247	11.143	No	No	Yes	Yes	9	9
45	E2	Lig	Shared	44.9843	75.8666	Yes	Yes	Yes	Yes	5	0
46	3x51	3x55	Shared	10.7917	20.8734	Yes	No	No	No	8	7
47	1x42	7x42	prostanoid_on	0	12.3026	No	No	No	No	8	8
48	7x42	Lig	prostanoid_on	3.8627	13.4993	No	No	Yes	Yes	8	0
49	1x42	7x43	prostanoid_on	0	11.0998	No	No	No	No	8	5
50	2x50	7x46	prostanoid_on	0.9296	17.4809	Yes	Yes	No	Yes	9	9
51	7x46	Lig	prostanoid_on	0	59.2277	No	Yes	Yes	Yes	9	0
52	6x37	8x47	prostanoid_on	0	34.5454	Yes	No	Yes	Yes	8	9
53	3x50	6x37	prostanoid_on	0	35.4028	Yes	No	Yes	No	9	8
54	2x39	3x46	prostanoid_on	1.89527	53.3463	Yes	Yes	No	No	8	9
55	3x46	7x53	prostanoid_on	0	89.2024	No	No	Yes	Yes	9	9
56	6x48	Lig	prostanoid_on	0	43.073	Yes	Yes	Yes	Yes	8	0
57	7x45	7x46	prostanoid_on	0	43.6097	Yes	Yes	No	Yes	9	9
58	1x50	2x47	prostanoid_on	1.80925	11.1553	Yes	Yes	No	No	9	8
59	1x54	2x47	prostanoid_on	0	10.3411	No	No	No	No	8	8
60	2x42	3x46	prostanoid_on	9.95921	48.4271	Yes	Yes	No	No	8	9
61	2x38	2x42	prostanoid_on	0	44.356	No	No	Yes	Yes	6	8
62	2x38	3x49	prostanoid_on	0	36.6118	No	No	Yes	No	6	9
63	3x49	I2x53	prostanoid_on	0	35.5385	Yes	No	No	Yes	9	8
64	2x46	2x50	prostanoid_on	0	17.2927	No	No	Yes	Yes	9	9
65	E1x50	E2	prostanoid_on	0	13.9403	Yes	Yes	Yes	Yes	6	5
66	E1	E1x50	prostanoid_on	0	10.5138	No	Yes	Yes	Yes	0	6
67	E2	E2x52	prostanoid_on	0	14.7298	Yes	Yes	Yes	Yes	5	7
68	3x52	I2x53	prostanoid_on	0	30.0179	No	No	No	Yes	6	8
69	3x52	3x56	prostanoid_on	0	28.8983	No	No	No	Yes	6	7
70	3x55	3x56	prostanoid_on	8.62169	22.0361	No	No	No	Yes	7	7
71	5x39	E2x52	prostanoid_on	0	10.6187	No	No	Yes	Yes	8	7
72	3x51	5x61	prostanoid_on	0	18.5171	Yes	No	No	No	8	9
73	5x61	5x65	prostanoid_on	0	17.6166	No	No	No	No	9	9
74	6x32	8x47	prostanoid_on	0	14.7823	Yes	No	Yes	Yes	8	9
75	3x50	6x38	prostanoid_on	0	10.4521	Yes	No	No	Yes	9	7
76	6x41	7x53	prostanoid_on	0	17.2681	No	No	Yes	Yes	8	9
77	4x60	E2	prostanoid_on	0	12.2841	No	No	Yes	Yes	9	5
78	4x60	5x39	prostanoid_on	1.63998	10.1838	No	No	No	No	9	8
79	4x56	5x39	prostanoid_on	0	18.659	Yes	No	No	No	7	8
80	4x52	4x56	prostanoid_on	0	11.8678	No	No	Yes	No	5	7
81	5x53	6x41	prostanoid_on	0	12.4568	No	Yes	No	No	6	8
82	2x46	7x49	prostanoid_on	0	16.019	No	No	No	No	9	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x36	2x65	Shared	3.215	6.915	0	1	2	1
1x38	1x39	prostanoid_off	4.265	0	0	0	2	1
1x39	2x60	prostanoid_off	5.71	0	1	0	1	1
1x39	2x64	prostanoid_off	3.32	0	1	0	1	1
1x43	2x57	prostanoid_off	12.43	0	1	0	1	1
2x50	3x39	Shared	10.86	9.12333	4	1	2	2
2x50	7x46	Shared	5.96	6.31167	4	1	2	1
2x54	7x46	Shared	3.44	3.85	0	1	1	1
2x57	2x58	prostanoid_off	3.49	0	1	1	1	1
2x59	3x28	prostanoid_off	3.555	0	0	0	2	2
2x60	2x64	prostanoid_off	5.515	0	1	0	1	1
2x60	Lig	prostanoid_off	8.085	0	1	0	1	0
2x64	Lig	prostanoid_off	6.4275	0	1	0	1	0
3x28	E1x50	prostanoid_off	7.055	0	0	1	2	2
E1x50	E2x50	prostanoid_off	7.185	0	1	1	2	2
3x25	E2	prostanoid_off	5.135	0	1	0	2	1
3x25	E2x50	Shared	7.28	7.28	1	0	2	2
3x26	E2	prostanoid_off	3.58	0	1	0	2	1
3x27	3x31	prostanoid_off	4.5325	0	0	0	2	2
3x29	E2	Shared	3.2	10.14	1	0	2	1
3x32	E2x51	Shared	3.045	4.35667	1	1	1	1
3x32	Lig	Shared	7.53	7.095	1	1	1	0
3x33	4x57	Shared	3.675	3.46	1	1	1	2
3x33	E2x52	Shared	4.72	5.55333	1	1	1	1
3x33	5x43	Shared	5.965	3.14	1	1	1	2
3x36	5x43	prostanoid_off	4.15	0	1	0	1	2
3x37	5x43	prostanoid_off	5.275	0	1	0	2	2
3x39	7x45	prostanoid_off	5.725	0	4	1	2	2
3x39	7x46	Shared	5.045	7.37	4	1	2	1
4x59	4x60	Shared	3.405	2.46	1	0	2	2
4x59	E2	prostanoid_off	5.535	0	1	0	2	1
4x60	5x39	Shared	6.0375	4.335	0	1	2	2
5x39	E2	prostanoid_off	3.4325	0	1	0	2	1
5x36	E2	Shared	10.745	7.06	1	1	2	1
E2	E2x50	Shared	4.1	3.56833	1	1	1	2
E2	E2	Shared	112.57	63.9717	1	1	1	1
E2	E2x51	Shared	9.0625	9.41667	1	1	1	1
E2	E3	Shared	7.7825	7.18333	1	1	1	2
E2	Lig	Shared	10.6875	14.3983	1	1	1	0
7x34	E2	Shared	5.025	4.375	1	1	2	1
7x38	E2	Shared	6.7525	6.64	1	1	1	1
E2x51	E2x52	Shared	10.72	12.28	1	1	1	1
6x51	E2x51	prostanoid_off	3.655	0	1	0	1	1
6x58	E2	Shared	12.995	4.95167	1	1	2	1
6x44	6x48	prostanoid_off	4.82	0	0	0	2	1
6x58	7x34	prostanoid_off	7.385	0	1	1	2	2
E3	E3	Shared	14.6825	11.405	1	1	2	2
7x32	7x35	prostanoid_off	6.5225	0	0	1	2	1
7x35	Lig	prostanoid_off	5.58	0	0	1	1	0
7x38	Lig	Shared	14.0225	7.32833	1	1	1	0
7x39	Lig	Shared	19.3425	5.04	0	0	1	0
7x42	Lig	Shared	7.615	10.56	1	0	1	0
2x63	Lig	prostanoid_off	4.365	0	0	0	1	0
3x33	Lig	prostanoid_off	3.575	0	1	1	1	0
4x65	Lig	prostanoid_off	3.565	0	1	0	1	0
E2x51	Lig	prostanoid_off	6.88	0	1	1	1	0
E2x52	Lig	prostanoid_off	4.965	0	1	1	1	0
6x51	Lig	prostanoid_off	3.82	0	1	0	1	0
7x31	Lig	prostanoid_off	3.71	0	1	0	1	0
NT	NT	Shared	22.18	24.11	1	1	2	2
E2	NT	Shared	35.255	11.4	1	1	1	2
5x32	NT	prostanoid_off	4.58	0	1	0	2	2
E3	NT	Shared	4.48	14.335	1	1	2	2
7x31	NT	prostanoid_off	4.655	0	1	0	1	2
E1x49	NT	prostanoid_off	4.61	0	1	0	2	2
1x43	2x58	prostanoid_off	5.345	0	1	0	1	1
2x57	7x42	prostanoid_off	4.265	0	1	1	1	1
2x64	E1	prostanoid_off	3.215	0	1	0	1	2
E1x49	E2	prostanoid_off	3.525	0	1	0	2	1
3x25	E1x50	prostanoid_off	5.225	0	1	0	2	2
3x22	E2	prostanoid_off	7.005	0	0	0	2	1
3x29	4x65	prostanoid_off	6.59	0	1	0	2	1
3x32	3x33	prostanoid_off	4.825	0	1	1	1	1
3x32	6x48	prostanoid_off	3.51	0	1	1	1	1
3x32	6x51	prostanoid_off	4.64	0	1	1	1	1
3x32	7x42	prostanoid_off	5.36	0	1	1	1	1
3x33	4x61	prostanoid_off	12.38	0	1	1	1	2
3x36	3x37	prostanoid_off	3.73	0	1	0	1	2
3x36	6x48	prostanoid_off	5.815	0	1	0	1	1
4x61	5x43	prostanoid_off	3.585	0	1	1	2	2
4x65	E2x52	prostanoid_off	3.6	0	1	0	1	1
6x58	E2x51	prostanoid_off	5.05	0	1	1	2	1
7x31	E2x51	prostanoid_off	3.86	0	1	0	1	1
5x36	E2x52	prostanoid_off	3.945	0	1	1	2	1
5x35	E2	Shared	3.22	2.505	1	0	2	1
5x32	E2	prostanoid_off	3.175	0	1	0	2	1
5x33	E3	prostanoid_off	8.93	0	0	1	2	2
5x43	6x51	prostanoid_off	5.97	0	1	0	2	1
5x43	6x52	prostanoid_off	3.275	0	1	0	2	2
5x43	6x55	prostanoid_off	3.06	0	1	0	2	2
6x48	7x41	Shared	3.89	5.18667	0	1	1	2
6x48	7x45	Shared	3.39	11.4883	0	1	1	2
6x51	6x52	prostanoid_off	5.99	0	1	0	1	2
7x31	7x34	prostanoid_off	3.985	0	1	0	1	2
1x43	2x61	prostanoid_off	2.855	0	1	0	1	1
1x39	7x43	prostanoid_off	2.83	0	1	0	1	2
1x36	2x64	prostanoid_off	2.64	0	0	1	2	1
3x36	5x461	prostanoid_off	2.415	0	1	0	1	2
1x35	2x64	prostanoid_off	2.18	0	0	0	2	1
1x43	1x47	prostanoid_off	1.965	0	1	0	1	2
1x40	1x43	Shared	1.855	0.76	0	0	2	1
1x46	2x54	prostanoid_off	1.855	0	0	0	2	1
1x43	2x55	prostanoid_off	1.825	0	1	0	1	2
4x59	4x63	prostanoid_off	1.655	0	1	0	2	2
5x34	5x35	prostanoid_off	1.32	0	0	0	2	2
7x28	E3	prostanoid_off	1.015	0	0	1	2	2
3x22	NT	prostanoid_on	0	3.64	0	0	2	2
7x28	NT	prostanoid_on	0	4.4	0	1	2	2
7x32	NT	prostanoid_on	0	12.515	0	1	2	2
1x36	NT	prostanoid_on	0	5.765	0	1	2	2
1x38	7x39	prostanoid_on	0	17.8167	0	0	2	1
1x39	Lig	prostanoid_on	0	8.43833	1	0	1	0
1x42	7x42	prostanoid_on	0	5.40667	0	0	2	1
1x42	7x43	prostanoid_on	0	12.195	0	0	2	2
1x43	Lig	prostanoid_on	0	3.58167	1	0	1	0
2x54	Lig	prostanoid_on	0	11.8383	0	1	1	0
2x57	3x28	prostanoid_on	0	5.13	1	1	1	2
2x57	3x32	prostanoid_on	0	3.84167	1	1	1	1
2x57	Lig	prostanoid_on	0	10.7983	1	1	1	0
2x60	3x28	prostanoid_on	0	12.9633	1	0	1	2
2x61	Lig	prostanoid_on	0	5.25333	0	0	1	0
2x64	E1x50	prostanoid_on	0	12.9767	1	0	1	2
2x65	E2	prostanoid_on	0	9.38667	0	1	1	1
2x65	Lig	prostanoid_on	0	6.48167	0	1	1	0
E1x50	E2	prostanoid_on	0	7.67667	1	1	2	1
3x26	4x61	prostanoid_on	0	4.585	1	0	2	2
3x28	3x32	prostanoid_on	0	6	0	1	2	1
3x33	E2	prostanoid_on	0	4.945	1	1	1	1
3x33	E2x51	prostanoid_on	0	4.06833	1	1	1	1
3x36	Lig	prostanoid_on	0	4.74667	1	0	1	0
3x40	6x48	prostanoid_on	0	17.655	0	0	2	1
4x60	E2	prostanoid_on	0	18.1683	0	1	2	1
5x33	E2	prostanoid_on	0	6.975	0	1	2	1
7x28	E2	prostanoid_on	0	7.715	0	1	2	1
7x31	E2	prostanoid_on	0	6.555	1	0	1	1
7x35	E2	prostanoid_on	0	3.805	0	1	1	1
E2	E2x52	prostanoid_on	0	4	1	1	1	1
5x39	E2x52	prostanoid_on	0	4.265	1	0	2	1
5x33	5x36	prostanoid_on	0	5.195	0	1	2	2
6x48	7x46	prostanoid_on	0	6.20667	0	1	1	1
6x48	Lig	prostanoid_on	0	3.68	0	1	1	0
6x51	6x55	prostanoid_on	0	5.36333	1	0	1	2
7x35	7x39	prostanoid_on	0	12.1483	0	1	1	1
7x45	7x46	prostanoid_on	0	6.16	0	1	2	1
7x46	Lig	prostanoid_on	0	5.365	4	1	1	0
2x63	E1	prostanoid_on	0	4.64333	0	0	1	2
E1	E1x50	prostanoid_on	0	5.47833	0	1	2	2
5x34	E2	prostanoid_on	0	12.575	0	0	2	1
5x32	5x33	prostanoid_on	0	3.99833	1	0	2	2
6x51	7x37	prostanoid_on	0	3.25	1	0	1	2
4x61	E2	prostanoid_on	0	3.21833	1	1	2	1
2x58	Lig	prostanoid_on	0	2.73167	1	0	1	0
5x37	E2x52	prostanoid_on	0	2.48167	0	0	2	1
2x57	3x31	prostanoid_on	0	2.37167	1	1	1	2
5x38	E2x52	prostanoid_on	0	2.345	0	0	2	1
1x47	2x55	prostanoid_on	0	2.33667	0	0	2	2
1x35	1x38	prostanoid_on	0	1.98	0	0	2	2
2x60	3x27	prostanoid_on	0	1.5	1	0	1	2
4x63	E2	prostanoid_on	0	0.795	0	0	2	1
2x59	2x60	prostanoid_on	0	0.76	0	0	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	prostanoid_off	ep_off dp_off
	prostanoid_on	tp_on fp-alpha_on

Network Difference
Value	prostanoid_off	prostanoid_on
I_min	3.0275	3.48833
Number of Linked Nodes	265	271
Number of Specific Nodes	16 (6.04%)	22 (8.12%)
Number of Shared Nodes	249 (93.96%)	249 (91.88%)
Number of Links	316	296
Number of Specific Links	213 (67.41%)	193 (65.20%)
Number of Shared Links	103 (32.59%)	103 (34.80%)
Number of Hubs	48	34
Number of Specific Hubs	29 (60.42%)	15 (44.12%)
Number of Shared Hubs	19 (39.58%)	19 (55.88%)
Average % Shared Neighbours (Jaccard)	20.04
Average % Shared Neighbours (Otsuka)	27.27
Average % Shared Neighbours (Overlap Coefficient)	34.65
Average % Shared Cliques (k3-6)	51.63
Graphlets Similarity	0.599391

Paths Difference
Value	prostanoid_off	prostanoid_on
Number Of Nodes in MetaPath	44	42
Specific Nodes in MetaPath	27 (61.36%)	25 (59.52%)
Shared Nodes in MetaPath	249 (93.96%)	249 (93.96%)
Number Of Links MetaPath	46	44
Specific Links in MetaPath	38 (82.61%)	36 (81.82%)
Shared Links in MetaPath	103 (32.59%)	103 (32.59%)
Number of Shortest Paths	69277	53724
Length Of Smallest Path	3	3
Average Path Length	11.205	12.7553
Length of Longest Path	25	29
Minimum Path Strength	0.785	0.363333
Average Path Strength	5.28912	6.28515
Maximum Path Strength	23	15.3717
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.907009	0.903847
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	4.7619	3.84615
Average % Of Corr. Nodes	45.0536	45.2725
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	54.9682	44.5007
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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