Orange: nodes, hubs and links specific of s1p5_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of s1p5_off network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.


Index Hub Owner s1p5_on_gp Avg Int. Strength s1p5_off Avg Int. Strength s1p5_on_gp Num Of Links s1p5_off Num Of Links ConSurf
1G.HN.33 s1p5_on_gp1.8450404
2G.S1.02 s1p5_on_gp5.8180505
3G.S1.06 s1p5_on_gp3.51250408
4G.H1.04 s1p5_on_gp4.38750407
5G.H1.07 s1p5_on_gp4.8480509
6G.S2.01 s1p5_on_gp50409
7G.S2.05 s1p5_on_gp5.2950403
8G.S2.08 s1p5_on_gp8.08250405
9G.S3.01 s1p5_on_gp4.70250404
10G.S3.03 s1p5_on_gp7.340507
11G.S3.04 s1p5_on_gp5.3420506
12G.S3.05 s1p5_on_gp3.316670607
13G.S3.06 s1p5_on_gp6.263330605
14G.S3.08 s1p5_on_gp3.70409
15G.s3h2.03 s1p5_on_gp4.018330609
16G.H2.04 s1p5_on_gp3.580409
17G.H2.06 s1p5_on_gp5.60609
18G.H2.07 s1p5_on_gp4.88750409
19G.h2s4.01 s1p5_on_gp5.480509
20G.S4.03 s1p5_on_gp3.5150407
21G.s4h3.01 s1p5_on_gp7.14750407
22G.s4h3.04 s1p5_on_gp7.4550408
23G.H3.01 s1p5_on_gp7.24250409
24G.H3.02 s1p5_on_gp3.070408
25G.H3.09 s1p5_on_gp5.49250409
26G.H3.13 s1p5_on_gp4.40250405
27G.H3.14 s1p5_on_gp6.89250408
28G.H3.17 s1p5_on_gp5.9340505
29G.S5.03 s1p5_on_gp3.440508
30G.S5.05 s1p5_on_gp3.883330609
31G.S5.07 s1p5_on_gp6.01250409
32G.HG.03 s1p5_on_gp5.5350406
33G.HG.14 s1p5_on_gp2.13750405
34G.hgh4.01 s1p5_on_gp3.670406
35G.hgh4.02 s1p5_on_gp3.476250807
36G.H4.11 s1p5_on_gp3.3350407
37G.H4.15 s1p5_on_gp3.49250408
38G.h4s6.02 s1p5_on_gp5.390408
39G.h4s6.04 s1p5_on_gp2.840404
40G.h4s6.11 s1p5_on_gp5.4250407
41G.S6.02 s1p5_on_gp5.460507
42G.s6h5.01 s1p5_on_gp5.4280509
43G.H5.03 s1p5_on_gp4.7550408
44G.H5.20 s1p5_on_gp5.2850409
45G.H5.23 s1p5_on_gp4.38250404
46G.H5.25 s1p5_on_gp4.06750407
47b.1x1 s1p5_on_gp2.7420504
48b.h2x1 s1p5_on_gp2.8850405
49b.h2x5 s1p5_on_gp4.85750405
50b.l1x3 s1p5_on_gp7.083330609
51b.b2x1 s1p5_on_gp6.29250408
52b.b2x5 s1p5_on_gp4.9760507
53b.b4x4 s1p5_on_gp8.62750408
54b.b4x5 s1p5_on_gp3.410407
55b.b4x6 s1p5_on_gp8.227140709
56b.b5x3 s1p5_on_gp5.647140709
57b.b5x5 s1p5_on_gp4.31250405
58b.b5x7 s1p5_on_gp3.620407
59b.l5x1 s1p5_on_gp4.81750408
60b.l5x5 s1p5_on_gp6.840609
61b.b6x5 s1p5_on_gp4.2440506
62b.b7x1 s1p5_on_gp5.540404
63b.b7x4 s1p5_on_gp3.31750408
64b.b8x4 s1p5_on_gp3.710506
65b.l8x8 s1p5_on_gp3.5650404
66b.l9x3 s1p5_on_gp7.366670609
67b.l9x6 s1p5_on_gp4.015710708
68b.l9x7 s1p5_on_gp3.5650407
69b.b10x5 s1p5_on_gp3.99750409
70b.b11x4 s1p5_on_gp5.0750409
71b.b11x5 s1p5_on_gp4.44750406
72b.l11x2 s1p5_on_gp7.350409
73b.b12x6 s1p5_on_gp9.280608
74b.l12x1 s1p5_on_gp3.790406
75b.b13x7 s1p5_on_gp5.9160507
76b.l13x3 s1p5_on_gp8.150509
77b.b14x3 s1p5_on_gp4.2440505
78b.b15x1 s1p5_on_gp5.9450609
79b.b16x4 s1p5_on_gp10.87750406
80b.b16x5 s1p5_on_gp3.2960505
81b.b16x6 s1p5_on_gp8.710608
82b.b17x7 s1p5_on_gp8.610408
83b.l17x3 s1p5_on_gp5.345710709
84b.l17x6 s1p5_on_gp5.62250409
85b.l17x7 s1p5_on_gp3.640407
86b.b18x3 s1p5_on_gp2.94250408
87b.l18x1 s1p5_on_gp4.834290706
88b.l18x2 s1p5_on_gp5.66750407
89b.b19x2 s1p5_on_gp5.5820506
90b.b19x4 s1p5_on_gp4.9940508
91b.l19x2 s1p5_on_gp5.3740509
92b.b20x2 s1p5_on_gp5.670406
93b.b20x4 s1p5_on_gp7.703330608
94b.b20x6 s1p5_on_gp7.630506
95b.l20x2 s1p5_on_gp8.7450409
96b.b21x1 s1p5_on_gp4.32750407
97b.b21x7 s1p5_on_gp5.401670605
98b.l21x5 s1p5_on_gp3.74750404
99b.b22x5 s1p5_on_gp4.6020507
100b.l22x5 s1p5_on_gp6.64750409
101b.b23x6 s1p5_on_gp6.720607
102b.b24x4 s1p5_on_gp8.420406
103b.b24x6 s1p5_on_gp5.54750408
104b.l24x3 s1p5_on_gp6.03250405
105b.b25x3 s1p5_on_gp7.4220505
106b.l25x3 s1p5_on_gp7.3760509
107b.l26x5 s1p5_on_gp4.0250405
108b.l27x1 s1p5_on_gp7.781430709
109b.l27x2 s1p5_on_gp9.150409
110b.b28x3 s1p5_on_gp4.4050407
111b.b28x6 s1p5_on_gp8.6640509
112b.b28x7 s1p5_on_gp4.790409
113g.ntx3 s1p5_on_gp3.04750404
114g.h1x1 s1p5_on_gp4.8650402
115g.l1x4 s1p5_on_gp4.4750408
116g.h2x11 s1p5_on_gp5.55750406
117g.ctx3 s1p5_on_gp6.703330609
118g.ctx14 s1p5_on_gp2.7650409
119g.ctx16 s1p5_on_gp4.9940508
1201x57 s1p5_on_gp4.493.65427
1212x38 s1p5_on_gp5.23755.065425
1223x33 s1p5_on_gp5.5456.465425
1233x43 s1p5_on_gp2.8464.93528
1243x46 s1p5_on_gp3.98754.28439
1253x50 s1p5_on_gp4.6147.42529
1263x54 s1p5_on_gp4.4150408
1273x56 s1p5_on_gp7.670505
1284x50 s1p5_on_gp3.08757.31439
1294x53 s1p5_on_gp3.084.91427
1304x56 s1p5_on_gp1.3155.60667436
1315x58 s1p5_on_gp5.168.44333539
1326x33 s1p5_on_gp4.28754.65428
1337x33 s1p5_on_gp5.57752.87414
1347x45 s1p5_on_gp8.9327.42333539
1357x50 s1p5_on_gp3.63610.1967539
136NT.H18 Shared8.4455.605448
137NT.Y19 Shared8.98256.06857479
1381x46 Shared4.59754.655447
1391x50 Shared5.286.346559
1402x46 Shared3.973.298459
1412x57 Shared8.886.188457
1422x61 Shared4.58254.13446
1433x25 Shared5.045718.45571779
1443x26 Shared4.666.052455
1453x28 Shared8.16758.19625485
1463x29 Shared7.64258.77333465
1474x42 Shared3.545.015446
148E2.Y189 Shared77.11572675
1495x39 Shared7.118339.29657
1506x44 Shared5.71256.6625449
1516x48 Shared8.59511.312459
1526x52 Shared5.96.4225447
153E3.C282 Shared4.27254.35444
1547x31 Shared3.84.57561
1557x49 Shared3.55255.945449
1567x53 Shared4.1365.982559
157Lig Shared7.122317.613130
158NT.I15 s1p5_off11.854.405147
159NT.Y21 s1p5_off7.226678.87345
160NT.K24 s1p5_off3.8354.535246
161NT.L25 s1p5_off5.915.4175246
1621x49 s1p5_off4.38.17348
1631x53 s1p5_off4.673333.765349
1641x60 s1p5_off05.67143070
165I1x50 s1p5_off09.315060
1662x39 s1p5_off7.536.818158
1672x40 s1p5_off5.4357.5725248
1682x47 s1p5_off2.496675.278359
169E1x501 s1p5_off4.514.8025346
1703x34 s1p5_off2.683332.0375345
1713x37 s1p5_off5.136675.8025346
172E2.W173 s1p5_off4.416.4075344
173E2.T184 s1p5_off4.4755.9475245
174E2.P187 s1p5_off14.046.0325244
175E2.L188 s1p5_off6.958.546354
1765x47 s1p5_off5.703336.9625348
1775x62 s1p5_off10.379.206356
1786x34 s1p5_off8.5356.816257
1796x58 s1p5_off4.256677.5375344
1806x61 s1p5_off4.644.6475345
1817x56 s1p5_off4.4954.0925247
1828x54 s1p5_off02.2525040
   
Orange: nodes, hubs and links specific of s1p5_on_gp network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of s1p5_off network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Owner s1p5_on_gp Recurrence s1p5_off Recurrence s1p5_on_gp Hub1? s1p5_off Hub1? s1p5_on_gp Hub2? s1p5_off Hub2? ConSurf1 ConSurf2
1G.HN.47 b.b5x3 s1p5_on_gp52.63190NoNoYesNo69
2G.HN.47 b.b4x2 s1p5_on_gp52.48520NoNoNoNo68
3b.b28x7 g.ctx16 s1p5_on_gp66.61790YesNoYesNo98
4b.b28x7 b.l26x5 s1p5_on_gp66.95190YesNoYesNo95
5b.l26x5 g.ctx4 s1p5_on_gp68.3190YesNoNoNo57
6g.ctx3 g.ctx4 s1p5_on_gp68.45750YesNoNoNo97
7g.ctx3 g.ctx6 s1p5_on_gp69.42460YesNoNoNo96
8b.l22x5 g.ctx6 s1p5_on_gp69.83790YesNoNoNo96
9b.l22x5 b.l24x2 s1p5_on_gp69.97210YesNoNoNo96
10b.h2x1 b.l24x2 s1p5_on_gp70.09160YesNoNoNo56
11b.b21x5 b.h2x1 s1p5_on_gp72.24840NoNoYesNo45
12b.b21x5 b.b21x7 s1p5_on_gp72.79230NoNoYesNo45
13b.b21x7 b.b24x6 s1p5_on_gp77.89730YesNoYesNo58
14b.b23x6 b.b24x6 s1p5_on_gp78.0630YesNoYesNo78
15b.b23x6 b.l23x2 s1p5_on_gp79.88150YesNoNoNo78
16b.l21x7 b.l23x2 s1p5_on_gp80.40760NoNoNoNo58
17b.l21x7 b.l23x1 s1p5_on_gp80.67020NoNoNoNo56
18b.l23x1 b.l25x6 s1p5_on_gp80.93250NoNoNoNo68
19b.l25x6 b.l27x1 s1p5_on_gp81.06360NoNoYesNo89
20b.b2x1 b.l27x1 s1p5_on_gp79.19470YesNoYesNo89
21b.b2x1 b.l3x1 s1p5_on_gp79.98630YesNoNoNo89
22b.l3x1 b.l5x5 s1p5_on_gp80.11120NoNoYesNo99
23G.S2.03 b.l5x5 s1p5_on_gp35.39520NoNoYesNo99
24G.S2.03 G.S3.04 s1p5_on_gp35.42010NoNoYesNo96
25G.S3.06 b.l5x5 s1p5_on_gp35.39890YesNoYesNo59
26G.S3.04 G.S3.06 s1p5_on_gp64.67020YesNoYesNo65
27G.S2.05 G.S3.04 s1p5_on_gp99.91420YesNoYesNo36
28G.H1.12 G.S2.05 s1p5_on_gp99.98970NoNoYesNo83
29G.H1.10 G.H1.12 s1p5_on_gp99.99240NoNoNoNo88
30G.H1.10 G.S2.04 s1p5_on_gp99.9950NoNoNoNo86
31G.S2.04 G.S3.05 s1p5_on_gp1000NoNoYesNo67
32G.S1.04 G.S3.05 s1p5_on_gp49.66610NoNoYesNo77
33G.S1.04 G.S3.03 s1p5_on_gp48.92560NoNoYesNo77
34G.S2.06 G.S3.05 s1p5_on_gp47.57440NoNoYesNo97
35G.S2.06 G.S3.03 s1p5_on_gp47.63020NoNoYesNo97
36G.H5.11 G.S3.03 s1p5_on_gp95.30080NoNoYesNo87
37G.S1.05 G.h2s4.01 s1p5_on_gp11.01950NoNoYesNo99
38G.S1.05 G.S1.07 s1p5_on_gp10.94960NoNoNoNo99
39G.S2.01 G.S3.08 s1p5_on_gp13.86660YesNoYesNo99
40G.S3.08 G.h2s4.01 s1p5_on_gp13.86620YesNoYesNo99
41G.H3.12 G.S1.07 s1p5_on_gp13.17880NoNoNoNo89
42G.H2.07 G.S3.08 s1p5_on_gp27.57880YesNoYesNo99
43G.H2.04 G.H2.07 s1p5_on_gp21.4120YesNoYesNo99
44G.H2.04 G.H3.08 s1p5_on_gp21.06690YesNoNoNo99
45G.H3.08 G.H3.12 s1p5_on_gp13.06520NoNoNoNo98
46G.H3.08 G.S4.04 s1p5_on_gp33.86010NoNoNoNo99
47G.S4.04 G.S4.06 s1p5_on_gp25.29390NoNoNoNo97
48G.H4.15 G.S4.06 s1p5_on_gp20.23910YesNoNoNo87
49G.H5.11 G.H5.15 s1p5_on_gp95.61630NoNoNoNo87
50G.H5.15 G.H5.19 s1p5_on_gp95.98920NoNoNoNo78
513x53 G.H5.23 s1p5_on_gp95.30180NoNoYesNo84
523x53 3x56 s1p5_on_gp95.40030NoNoYesNo85
533x56 G.H5.19 s1p5_on_gp95.89130YesNoNoNo58
543x50 G.H5.23 s1p5_on_gp93.15880YesNoYesNo94
553x50 5x58 s1p5_on_gp16.94380YesNoYesNo99
56b.b4x2 b.b5x8 s1p5_on_gp52.45080NoNoNoNo85
57b.b5x7 b.b5x8 s1p5_on_gp52.30360YesNoNoNo75
58b.b4x3 b.b5x7 s1p5_on_gp48.59250NoNoYesNo77
59b.b3x3 b.b4x3 s1p5_on_gp47.42720NoNoNoNo87
60b.b3x3 b.b6x5 s1p5_on_gp47.11670NoNoYesNo86
61b.b2x4 b.b6x5 s1p5_on_gp47.27120NoNoYesNo66
62b.b10x4 b.b2x4 s1p5_on_gp47.120NoNoNoNo66
63b.b10x4 b.b14x3 s1p5_on_gp46.80630NoNoYesNo65
64b.b14x3 b.b15x1 s1p5_on_gp45.05940YesNoYesNo59
65b.b15x1 b.b16x6 s1p5_on_gp12.27010YesNoYesNo98
66g.h1x11 g.h1x14 s1p5_on_gp10.04060NoNoNoNo99
67b.b15x1 b.l16x1 s1p5_on_gp23.66150YesNoNoNo94
68b.l16x1 b.l16x2 s1p5_on_gp23.1440NoNoNoNo49
69b.l14x5 b.l16x2 s1p5_on_gp11.75420NoNoNoNo59
70b.l14x5 b.l14x6 s1p5_on_gp10.57630NoNoNoNo53
71b.b16x5 b.l14x6 s1p5_on_gp10.41220YesNoNoNo53
72b.b16x5 b.b17x5 s1p5_on_gp11.83160YesNoNoNo57
73b.b16x7 b.l16x2 s1p5_on_gp11.2390NoNoNoNo99
74b.b16x7 b.b17x4 s1p5_on_gp10.74230NoNoNoNo95
75b.b16x5 b.b17x4 s1p5_on_gp10.54520YesNoNoNo55
76b.b4x6 b.b5x3 s1p5_on_gp53.1090YesNoYesNo99
77b.b1x6 b.b4x6 s1p5_on_gp54.95080NoNoYesNo99
78b.b1x6 b.b5x1 s1p5_on_gp55.57040NoNoNoNo95
79b.b1x4 b.b5x1 s1p5_on_gp55.71480NoNoNoNo75
80b.b28x5 g.ctx16 s1p5_on_gp56.14850NoNoYesNo58
813x25 3x29 s1p5_on_gp16.38868.34286YesYesYesYes95
823x36 Lig s1p5_on_gp32.11940NoNoYesYes70
833x36 6x48 s1p5_on_gp32.37694.42701NoNoYesYes79
846x44 6x48 s1p5_on_gp32.32880.0679154YesYesYesYes99
853x43 6x44 s1p5_on_gp32.69250YesNoYesYes89
863x43 7x53 s1p5_on_gp68.98210YesNoYesYes89
873x50 7x53 s1p5_on_gp68.98950YesNoYesYes99
883x40 Lig s1p5_on_gp47.99270NoNoYesYes80
893x40 6x48 s1p5_on_gp32.37920NoNoYesYes89
906x48 7x45 s1p5_on_gp32.67955.33314YesYesYesNo99
913x43 7x45 s1p5_on_gp33.20980YesNoYesNo89
923x40 5x50 s1p5_on_gp16.01167.26158NoNoNoNo88
933x44 5x50 s1p5_on_gp16.13446.36617NoNoNoNo78
943x44 5x54 s1p5_on_gp16.3815.46719NoNoNoNo78
955x54 5x58 s1p5_on_gp16.50770NoNoYesNo89
966x57 E3.C282 s1p5_on_gp13.13330NoNoYesYes54
976x54 6x57 s1p5_on_gp14.44490NoNoNoNo55
986x54 6x55 s1p5_on_gp17.72260NoNoNoNo56
996x51 6x55 s1p5_on_gp18.37790NoNoNoNo76
1006x51 Lig s1p5_on_gp19.68830NoNoYesYes70
1013x37 Lig s1p5_on_gp10.50690NoYesYesYes60
102b.b1x4 b.b28x5 s1p5_on_gp56.00360NoNoNoNo75
103G.S3.06 G.h2s4.01 s1p5_on_gp18.83030YesNoYesNo59
104G.S2.01 G.S3.06 s1p5_on_gp10.47310YesNoYesNo95
1053x25 NT.Y19 Shared12.475918.8233YesYesYesYes99
1063x29 Lig Shared19.009641.423YesYesYesYes50
107Lig NT.Y19 s1p5_off020.943YesYesYesYes09
1083x28 Lig s1p5_off018.1781YesYesYesYes50
1093x25 3x28 s1p5_off0.0092784810.8236YesYesYesYes95
1103x25 E2.L188 s1p5_off1.9712522.2995YesYesNoYes94
111E2.L188 NT.H18 s1p5_off027.579NoYesYesYes48
112E2.L179 NT.H18 s1p5_off013.8851NoNoYesYes28
113E2.C182 NT.H18 s1p5_off0.65717411.5778NoNoYesYes98
114Lig NT.K24 s1p5_off2.6291219.4363YesYesNoYes06
115NT.K24 NT.T22 s1p5_off1.9719525.4772NoYesNoNo68
116E2.P187 Lig s1p5_off019.4363NoYesYesYes40
117E2.P187 NT.T22 s1p5_off025.4772NoYesNoNo48
118E2.T184 NT.T22 s1p5_off049.4692NoYesNoNo58
1191x46 2x54 s1p5_off022.3227YesYesNoNo77
1202x54 2x57 s1p5_off023.2128NoNoYesYes77
1212x57 Lig s1p5_off0100YesYesYesYes70
1221x49 7x47 s1p5_off021.2325NoYesNoNo86
1231x46 7x47 s1p5_off0.014112621.5399YesYesNoNo76
1242x53 7x46 s1p5_off076.7944NoNoNoNo89
1252x53 2x57 s1p5_off078.117NoNoYesYes87
1261x50 2x50 s1p5_off0.061050844.3112YesYesNoNo99
1272x50 7x46 s1p5_off0.65343176.882NoNoNoNo99
1281x49 7x50 s1p5_off0.2723920.3782NoYesYesNo89
1291x50 7x50 s1p5_off2.8576520.9501YesYesYesNo99
1301x50 2x47 s1p5_off022.1225YesYesNoYes99
1311x53 2x47 s1p5_off2.2226620.7088NoYesNoYes99
1321x53 7x50 s1p5_off2.4873740.5204NoYesYesNo99
1331x53 7x53 s1p5_off021.8151NoYesYesYes99
1347x49 7x53 s1p5_off021.2861YesYesYesYes99
1352x50 7x49 s1p5_off032.9622NoNoYesYes99
1361x56 8x54 s1p5_off058.8898NoNoNoYes70
1371x53 8x54 s1p5_off081.0069NoYesNoYes90
1381x56 1x60 s1p5_off013.5366NoNoNoYes70
1391x56 I1x50 s1p5_off043.473NoNoNoYes70
1402x40 I1x50 s1p5_off032.2223NoYesNoYes80
1412x39 2x40 s1p5_off028.5262NoYesNoYes88
1422x39 3x50 s1p5_off022.8928NoYesYesNo89
1433x37 4x56 s1p5_off036.1792NoYesYesNo66
1444x56 5x39 s1p5_off2.6291236.8673YesNoYesYes67
1455x39 E2.Y189 s1p5_off0.012046442.2469YesYesYesYes75
1463x29 E2.Y189 s1p5_off1.3115833.4376YesYesYesYes55
1473x37 5x47 s1p5_off027.3127NoYesNoYes68
1483x40 5x47 s1p5_off013.3221NoNoNoYes88
1496x31 6x34 s1p5_off019.3416NoNoNoYes47
1503x50 6x31 s1p5_off021.1145YesNoNoNo94
1516x58 E2.T184 s1p5_off0.6572921.6918NoYesNoYes45
1527x31 E2.T184 s1p5_off024.7909YesYesNoYes15
1536x58 E2.V185 s1p5_off011.0648NoYesNoNo44
1547x54 8x54 s1p5_off014.2158NoNoNoYes70
1553x25 E2.Y189 s1p5_off0.015438110.9969YesYesYesYes95

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Midway



Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Node1Node2OwnerNet1LinkStrengthNet2LinkStrengthComm1Comm2Node1ShellNode2Shell
LigNT.Y19s1p5_off7.3501001
LigNT.K24Shared3.534.671001
2x57Ligs1p5_off10.2801010
2x60LigShared8.611.821010
2x61Ligs1p5_off4.4700010
3x28Ligs1p5_off4.5701610
3x29LigShared14.129.651610
3x32LigShared7.470.991010
E2.P187Ligs1p5_off3.0901010
7x35Ligs1p5_off5.95003010
7x38LigShared19.957.330010
7x39Ligs1p5_off3.2200010
7x42Ligs1p5_off6.201010
NT.I15NT.Y19s1p5_off3.6301021
3x25NT.I15s1p5_off3.5201622
NT.K24NT.Y19s1p5_off3.5801011
E1x50NT.Y19s1p5_off3.7501621
E1x501NT.Y19Shared5.863.521621
3x25NT.Y19Shared5.793.861621
E2.P187NT.Y19Shared12.5225.031011
NT.K24NT.T22Shared6.0131012
E2.P187NT.T22s1p5_off3.501012
E2.P187NT.K24s1p5_off5.0201011
E1x501NT.L25Shared4.158.31622
1x392x61s1p5_off3.2700021
1x397x42s1p5_off3.2400021
1x402x61Shared7.144.280021
2x532x57s1p5_off5.3400021
2x537x46s1p5_off3.4200022
2x542x57s1p5_off4.3500021
2x573x32s1p5_off3.7901011
2x577x42s1p5_off7.1801011
2x603x28Shared9.643.621011
2x603x29s1p5_off10.5201011
2x633x28Shared3.6414.580621
2x64E1x50s1p5_off3.201022
2x643x28s1p5_off9.2201021
3x28E1x50Shared11.646.471612
3x28E1x52s1p5_off6.0701612
3x253x28Shared881621
3x253x29Shared6.543.271621
3x25E2.Y189Shared4.825.791622
3x283x29s1p5_off12.7901611
3x29E2.L186Shared5.35.31612
3x29E2.Y189Shared3.3712.351612
3x33E2.L186s1p5_off3.6501612
3x33E2.Y189Shared9.284.131612
3x365x47s1p5_off7.3104011
3x366x48Shared15.946.834012
3x366x52s1p5_off3.6504012
3x374x53Shared6.43.20012
3x374x56s1p5_off7.3700012
3x375x47s1p5_off6.4900011
3x405x47s1p5_off6.5500011
3x405x50Shared4.613.070012
3x406x44s1p5_off3.9300012
4x565x39Shared4.691.171022
4x565x43s1p5_off4.7601021
6x55E2.V185s1p5_off4.4700022
E2.L186E2.Y189Shared11.728.211622
5x39E2.Y189Shared3.975.961622
5x395x43s1p5_off9.4101621
5x476x52Shared7.59.6543212
6x446x48Shared13.037.024322
6x486x52s1p5_off13.0304322
6x487x41s1p5_off7.7804322
3x373x41Shared2.951.470012
6x517x38s1p5_off2.7700011
7x34E2.V185s1p5_off1.700012
1x432x61s1p5_off1.6400021
E2.P187NT.H18s1p5_on_gp03.051012
NT.L25NT.Y19s1p5_on_gp03.521621
1x357x33s1p5_on_gp06.5303022
1x357x35s1p5_on_gp03.9903021
1x392x57s1p5_on_gp08.060021
2x563x32s1p5_on_gp03.390021
2x572x61s1p5_on_gp010.881011
2x577x38s1p5_on_gp015.241011
2x63E1x50s1p5_on_gp02.950622
E1x50E1x52s1p5_on_gp05.91622
3x25E2.L186s1p5_on_gp04.561622
3x335x39s1p5_on_gp09.281612
3x33Ligs1p5_on_gp07.261610
3x36Ligs1p5_on_gp07.334010
3x37Ligs1p5_on_gp010.740010
3x406x48s1p5_on_gp02.450012
3x40Ligs1p5_on_gp07.890010
5x43Ligs1p5_on_gp011.561010
5x475x48s1p5_on_gp02.6243212
5x47Ligs1p5_on_gp04.8443210
5x486x52s1p5_on_gp03.9303222
6x516x55s1p5_on_gp05.540012
6x51Ligs1p5_on_gp06.420010
7x337x35s1p5_on_gp05.2203021
7x387x42s1p5_on_gp02.830011
7x427x46s1p5_on_gp07.671012
7x34Ligs1p5_on_gp02.090010
1x397x39s1p5_on_gp01.960021
2x532x54s1p5_on_gp01.950022
1x362x61s1p5_on_gp01.620021
6x517x41s1p5_on_gp01.580012
2x612x64s1p5_on_gp01.550012
3x334x57s1p5_on_gp01.511612
1x432x57s1p5_on_gp01.340021

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
Id Description
s1p5_on_gp 7EW1-S1P5-Siponimod-Gi1/β1/γ2
s1p5_off 7YXA-S1P5-ONO-5430608
Network Difference
Value s1p5_on_gp s1p5_off
Imin 2.39 3.07
Number of Linked Nodes 828 252
Number of Specific Nodes 626 (75.60%) 50  (19.84%)
Number of Shared Nodes 202 (24.40%) 202  (80.16%)
Number of Links 1005 299
Number of Specific Links 898 (89.35%) 192  (64.21%)
Number of Shared Links 107 (10.65%) 107  (35.79%)
Number of Hubs 157 47
Number of Specific Hubs 135 (85.99%) 25  (53.19%)
Number of Shared Hubs 22 (14.01%) 22  (46.81%)
Average % Shared Neighbours (Jaccard) 7.33
Average % Shared Neighbours (Otsuka) 9.52
Average % Shared Neighbours (Overlap Coefficient) 11.27
Average % Shared Cliques (k3-6) 51.05
Graphlets Similarity 0.791839
Paths Difference
Value s1p5_on_gp s1p5_off
Number Of Nodes in MetaPath 100 46
Specific Nodes in MetaPath 92 (92.00%) 38  (82.61%)
Shared Nodes in MetaPath 202 (24.40%) 202  (24.40%)
Number Of Links MetaPath 106 51
Specific Links in MetaPath 104 (98.11%) 49  (96.08%)
Shared Links in MetaPath 107 (10.65%) 107  (10.65%)
Number of Shortest Paths 3231581 86770
Length Of Smallest Path 3 3
Average Path Length 48.1635 15.2146
Length of Longest Path 85 32
Minimum Path Strength 1.13 1.32
Average Path Strength 5.19913 6.00957
Maximum Path Strength 16.885 19.625
Minimum Path Correlation 0.7 0.7
Average Path Correlation 0.990974 0.926078
Maximum Path Correlation 1 0.99
Minimum % Of Corr. Nodes 1.63934 3.57143
Average % Of Corr. Nodes 32.9263 42.3295
Maximum % Of Corr. Nodes 100 100
Minimum Path Hubs % 0 0
Average Path Hubs % 48.3885 55.1428
Maximum Path Hubs % 100 100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download s1p5_off_on_gp.zip<



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