psnGPCR

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Orange: nodes, hubs and links specific of vasopressin-ot_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of vasopressin-ot_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	vasopressin-ot_off Int. Strength	vasopressin-ot_on Int. Strength	vasopressin-ot_off Hub1?	vasopressin-ot_on Hub1?	vasopressin-ot_off Hub2?	vasopressin-ot_on Hub2?	ConSurf1	ConSurf2
1	1x42	7x43	vasopressin-ot_off	4.28	0	No	No	No	No	7	5
2	1x45	7x51	vasopressin-ot_off	14.81	0	No	No	No	No	5	6
3	1x50	2x47	vasopressin-ot_off	5.96	0	No	No	No	No	9	9
4	1x53	7x53	vasopressin-ot_off	6.31	0	No	No	Yes	Yes	9	9
5	1x54	2x48	vasopressin-ot_off	4.28	0	No	No	No	No	7	6
6	2x38	I1x51	vasopressin-ot_off	10.16	0	Yes	No	Yes	No	7	7
7	3x49	I1x51	vasopressin-ot_off	15.13	0	No	No	Yes	No	9	7
8	3x50	I1x51	vasopressin-ot_off	6.77	0	Yes	No	Yes	No	9	7
9	3x53	I1x51	vasopressin-ot_off	4.39	0	No	No	Yes	No	8	7
10	I1x51	I2	vasopressin-ot_off	9.32	0	Yes	No	Yes	No	7	7
11	2x37	2x38	vasopressin-ot_off	5.27	0	No	No	Yes	No	8	7
12	2x38	2x42	vasopressin-ot_off	4.28	0	Yes	No	Yes	No	7	8
13	2x38	4x39	vasopressin-ot_off	7.46	0	Yes	No	No	No	7	4
14	2x39	3x50	vasopressin-ot_off	9.72	0	No	No	Yes	No	8	9
15	2x39	6x33	vasopressin-ot_off	4.42	0	No	No	No	No	8	8
16	2x41	2x42	vasopressin-ot_off	4.29	0	Yes	No	Yes	No	5	8
17	2x41	2x45	vasopressin-ot_off	13.58	0	Yes	No	No	No	5	9
18	2x41	4x46	vasopressin-ot_off	5.24	0	Yes	No	No	No	5	7
19	2x45	4x50	vasopressin-ot_off	5.29	0	No	No	Yes	Yes	9	9
20	2x50	7x49	vasopressin-ot_off	5.53	0	No	Yes	No	No	9	9
21	2x56	2x60	vasopressin-ot_off	5.12	0	Yes	Yes	No	No	7	7
22	2x60	7x38	vasopressin-ot_off	6.8	0	No	No	No	No	7	6
23	2x63	2x64	vasopressin-ot_off	5.58	0	No	No	No	No	5	5
24	2x63	2x67	vasopressin-ot_off	8.02	0	No	No	No	No	5	4
25	E1x50	E2x50	vasopressin-ot_off	6.98	0	Yes	Yes	No	No	7	9
26	3x25	E2	vasopressin-ot_off	4.76	0	No	No	Yes	Yes	9	4
27	3x26	4x62	vasopressin-ot_off	5.23	0	No	No	No	No	6	5
28	3x29	E2x50	vasopressin-ot_off	6.47	0	Yes	No	No	No	4	9
29	3x29	Lig	vasopressin-ot_off	9.73	0	Yes	No	Yes	Yes	4	0
30	3x30	3x34	vasopressin-ot_off	8.83	0	No	Yes	No	No	7	6
31	3x33	5x43	vasopressin-ot_off	5.71	0	Yes	No	No	Yes	5	5
32	3x34	4x54	vasopressin-ot_off	4.47	0	No	No	No	No	6	3
33	3x36	6x48	vasopressin-ot_off	5.82	0	No	No	Yes	Yes	6	8
34	3x36	Lig	vasopressin-ot_off	8.67	0	No	No	Yes	Yes	6	0
35	3x41	3x44	vasopressin-ot_off	4.69	0	No	No	Yes	No	6	7
36	3x43	6x40	vasopressin-ot_off	4.28	0	No	No	Yes	No	8	8
37	3x43	6x41	vasopressin-ot_off	4.47	0	No	No	Yes	No	8	8
38	3x44	5x50	vasopressin-ot_off	6.57	0	Yes	No	No	No	7	9
39	3x44	5x54	vasopressin-ot_off	5.54	0	Yes	No	No	No	7	8
40	3x46	6x37	vasopressin-ot_off	4.52	0	No	No	No	No	8	8
41	3x49	3x50	vasopressin-ot_off	7.15	0	No	No	Yes	No	9	9
42	3x50	6x33	vasopressin-ot_off	7.76	0	Yes	No	No	No	9	8
43	3x50	6x34	vasopressin-ot_off	5.23	0	Yes	No	No	No	9	7
44	3x50	6x37	vasopressin-ot_off	9.06	0	Yes	No	No	No	9	8
45	3x52	I2	vasopressin-ot_off	5.54	0	No	Yes	Yes	No	3	7
46	3x54	6x30	vasopressin-ot_off	5.82	0	Yes	No	No	No	8	8
47	4x61	4x64	vasopressin-ot_off	5.49	0	Yes	Yes	Yes	No	6	5
48	4x64	5x39	vasopressin-ot_off	12.09	0	Yes	No	Yes	No	5	7
49	4x65	Lig	vasopressin-ot_off	5.6	0	Yes	Yes	Yes	Yes	6	0
50	5x39	E2	vasopressin-ot_off	6.19	0	Yes	No	Yes	Yes	7	4
51	5x34	5x35	vasopressin-ot_off	5.63	0	No	No	No	No	2	4
52	5x45	5x48	vasopressin-ot_off	7.14	0	No	No	No	No	5	5
53	5x54	6x41	vasopressin-ot_off	11.92	0	No	No	Yes	No	8	8
54	5x58	6x38	vasopressin-ot_off	13.41	0	Yes	Yes	No	No	9	6
55	5x58	6x41	vasopressin-ot_off	6.31	0	Yes	Yes	Yes	No	9	8
56	5x64	6x25	vasopressin-ot_off	14.1	0	No	No	No	No	6	3
57	6x36	8x47	vasopressin-ot_off	5.78	0	No	No	No	No	8	8
58	6x39	7x56	vasopressin-ot_off	6.28	0	No	No	Yes	No	7	7
59	6x40	7x49	vasopressin-ot_off	5.82	0	Yes	No	No	No	8	9
60	6x40	7x52	vasopressin-ot_off	4.42	0	Yes	No	No	No	8	8
61	6x48	7x41	vasopressin-ot_off	7.78	0	Yes	Yes	No	No	8	7
62	6x48	Lig	vasopressin-ot_off	7.86	0	Yes	Yes	Yes	Yes	8	0
63	6x56	6x60	vasopressin-ot_off	6.98	0	No	No	No	No	6	5
64	7x29	7x32	vasopressin-ot_off	10.71	0	No	No	No	No	4	2
65	7x35	7x39	vasopressin-ot_off	4.28	0	No	No	No	Yes	4	5
66	2x46	3x46	vasopressin-ot_off	4.24	0	No	No	No	No	9	8
67	3x37	4x53	vasopressin-ot_off	4.19	0	Yes	Yes	No	No	6	8
68	1x47	2x51	vasopressin-ot_off	4.15	0	No	No	No	No	6	7
69	1x49	7x50	vasopressin-ot_off	4.06	0	No	No	No	No	8	9
70	1x35	1x39	vasopressin-ot_off	3.98	0	No	Yes	No	No	5	6
71	1x49	1x52	vasopressin-ot_off	3.92	0	No	No	No	No	8	6
72	7x55	7x56	vasopressin-ot_off	3.65	0	No	No	Yes	No	5	7
73	2x59	3x28	vasopressin-ot_off	3.53	0	No	No	No	No	4	6
74	6x50	7x37	vasopressin-ot_off	3.53	0	No	No	No	No	9	5
75	6x55	7x34	vasopressin-ot_off	3.51	0	No	Yes	Yes	No	6	4
76	6x30	I2	vasopressin-ot_off	3.35	0	No	No	Yes	No	8	7
77	2x58	2x59	vasopressin-ot_off	3.28	0	No	No	No	No	8	4
78	6x50	7x40	vasopressin-ot_off	3.28	0	No	No	No	No	9	7
79	7x48	7x52	vasopressin-ot_off	3.27	0	No	No	No	No	6	8
80	4x39	4x43	vasopressin-ot_off	3.2	0	No	No	No	Yes	4	3
81	1x38	1x42	vasopressin-ot_off	3.07	0	No	Yes	No	No	4	7
82	5x44	5x48	vasopressin-ot_off	3.04	0	No	No	No	No	5	5
83	1x53	1x57	vasopressin-ot_off	2.98	0	No	No	Yes	No	9	7
84	5x61	5x65	vasopressin-ot_off	2.94	0	No	No	No	No	8	8
85	6x26	6x31	vasopressin-ot_off	2.94	0	No	No	No	No	6	6
86	3x54	5x64	vasopressin-ot_off	2.91	0	Yes	No	No	No	8	6
87	1x39	7x38	vasopressin-ot_off	2.83	0	No	No	No	No	6	6
88	2x42	4x42	vasopressin-ot_off	2.77	0	Yes	No	No	No	8	7
89	5x67	5x68	vasopressin-ot_off	2.64	0	No	No	No	No	5	7
90	4x38	4x41	vasopressin-ot_off	2.59	0	No	No	No	No	4	7
91	1x57	2x40	vasopressin-ot_off	2.44	0	Yes	No	No	Yes	7	9
92	3x23	3x26	vasopressin-ot_off	2.43	0	No	No	No	No	3	6
93	4x38	4x40	vasopressin-ot_off	2.13	0	No	No	No	No	4	5
94	3x35	3x38	vasopressin-ot_off	1.95	0	No	No	No	No	6	7
95	4x59	4x60	vasopressin-ot_off	1.87	0	No	No	No	No	4	7
96	2x54	7x46	vasopressin-ot_off	1.81	0	No	No	No	No	7	9
97	7x30	E3	vasopressin-ot_off	1.57	0	No	No	Yes	Yes	4	4
98	6x41	6x45	vasopressin-ot_off	1.54	0	Yes	No	No	No	8	6
99	6x45	6x46	vasopressin-ot_off	1.54	0	No	No	No	No	6	6
100	2x65	2x66	vasopressin-ot_off	1.52	0	No	No	No	No	5	6
101	3x28	3x29	vasopressin-ot_off	1.52	0	No	No	Yes	No	6	4
102	3x54	6x31	vasopressin-ot_off	1.47	0	Yes	No	No	No	8	6
103	4x41	I2	vasopressin-ot_off	1.47	0	No	No	Yes	No	7	7
104	6x28	6x31	vasopressin-ot_off	1.45	0	No	No	No	No	6	6
105	7x33	7x34	vasopressin-ot_off	1.39	0	No	No	Yes	No	5	4
106	1x57	8x50	vasopressin-ot_off	1.38	0	Yes	No	No	No	7	8
107	4x47	4x51	vasopressin-ot_off	1.38	0	No	No	No	No	3	4
108	1x58	2x44	vasopressin-ot_off	1.31	0	No	No	No	No	2	6
109	2x52	2x551	vasopressin-ot_off	1.31	0	No	No	No	No	6	5
110	7x53	7x54	vasopressin-ot_off	1.2	0	Yes	Yes	No	No	9	7
111	1x28	1x31	Shared	9.61	6.15	No	No	No	Yes	5	5
112	1x29	1x33	Shared	6.98	8.28	No	No	No	No	5	5
113	1x35	2x64	Shared	12.99	3.375	No	Yes	No	No	5	5
114	1x40	2x61	Shared	4.76	2.25	No	No	No	No	4	7
115	1x42	7x47	Shared	6.55	2.49	No	No	No	No	7	7
116	1x43	2x57	Shared	5.96	2.89	No	No	No	No	6	7
117	1x45	7x47	Shared	6.35	3.285	No	No	No	No	5	7
118	1x50	7x50	Shared	11.4	7.335	No	No	No	No	9	9
119	1x53	2x47	Shared	4.85	6.56	No	No	No	No	9	9
120	1x56	8x50	Shared	4.73	2.365	No	No	No	No	7	8
121	2x42	3x45	Shared	9.74	3.74	Yes	No	No	No	8	7
122	2x42	3x46	Shared	4.98	8.085	Yes	No	No	No	8	8
123	2x42	3x49	Shared	9.55	9.555	Yes	No	No	No	8	9
124	2x43	7x53	Shared	16.76	3.605	No	No	Yes	Yes	7	9
125	2x45	4x46	Shared	8.3	13.835	No	No	No	No	9	7
126	2x50	3x39	Shared	4.42	2.945	No	Yes	No	No	9	9
127	2x50	7x46	Shared	4.67	11.045	No	Yes	No	No	9	9
128	2x55	2x551	Shared	7.87	5.055	No	No	No	No	5	5
129	2x551	3x31	Shared	10.96	12.175	No	No	No	No	5	5
130	2x56	3x32	Shared	11.52	3.84	Yes	Yes	No	Yes	7	7
131	2x56	7x42	Shared	4.33	7.22	Yes	Yes	No	No	7	7
132	2x56	Lig	Shared	30.6	15.78	Yes	Yes	Yes	Yes	7	0
133	2x66	E1x51	Shared	8.74	2.585	No	No	No	No	6	3
134	E1x49	E1x51	Shared	23.66	2.06	No	No	No	No	5	3
135	E1x49	E2	Shared	7.85	13.99	No	No	Yes	Yes	5	4
136	E1x50	E1x52	Shared	4.52	3.765	Yes	Yes	No	No	7	6
137	3x25	E1x50	Shared	6.98	9.775	No	No	Yes	Yes	9	7
138	E1x50	E2	Shared	6.06	3.555	Yes	Yes	Yes	Yes	7	4
139	3x21	3x24	Shared	11.49	6.57	No	No	No	No	7	5
140	3x22	3x26	Shared	16.68	8.935	No	No	No	No	4	6
141	3x22	E2	Shared	12.44	12.16	No	No	Yes	Yes	4	4
142	3x25	E2x50	Shared	5.46	6.37	No	No	No	No	9	9
143	3x29	3x32	Shared	8.14	7.455	Yes	No	No	Yes	4	7
144	3x29	4x65	Shared	17.37	13.03	Yes	No	Yes	Yes	4	6
145	3x30	4x54	Shared	5.86	4.685	No	Yes	No	No	7	3
146	3x32	Lig	Shared	16.32	5.075	No	Yes	Yes	Yes	7	0
147	3x33	3x37	Shared	6.09	4.9	Yes	No	Yes	Yes	5	6
148	3x33	4x57	Shared	9.01	6.295	Yes	No	No	No	5	7
149	3x33	4x61	Shared	14.64	9.095	Yes	No	Yes	Yes	5	6
150	3x34	4x57	Shared	6.46	4.85	No	No	No	No	6	7
151	3x37	3x41	Shared	6.19	8.155	Yes	Yes	No	No	6	6
152	3x37	4x56	Shared	7.87	9.435	Yes	Yes	No	No	6	5
153	3x37	5x461	Shared	7.87	4.515	Yes	Yes	No	No	6	5
154	3x38	4x50	Shared	5.19	4.54	No	No	Yes	Yes	7	9
155	3x40	6x44	Shared	7.78	3.855	No	No	No	Yes	8	9
156	3x42	4x50	Shared	4.56	3.49	No	Yes	Yes	Yes	8	9
157	3x47	5x54	Shared	4.5	3.02	No	No	No	No	8	8
158	3x47	5x58	Shared	6.36	4.595	No	No	Yes	Yes	8	9
159	3x48	5x57	Shared	4.76	3.17	No	No	No	No	6	6
160	3x51	5x57	Shared	7.28	5.115	No	Yes	No	No	7	6
161	3x51	5x61	Shared	4.91	4.445	No	Yes	No	No	7	8
162	3x54	5x61	Shared	10.3	1.47	Yes	No	No	No	8	8
163	3x56	I2	Shared	13.26	0.79	No	Yes	Yes	No	5	7
164	4x61	4x65	Shared	5.86	8.785	Yes	Yes	Yes	Yes	6	6
165	4x61	5x39	Shared	6.76	7.895	Yes	Yes	Yes	No	6	7
166	4x61	Lig	Shared	5.1	4.7	Yes	Yes	Yes	Yes	6	0
167	4x64	4x65	Shared	6.28	3.77	Yes	No	Yes	Yes	5	6
168	4x64	E2	Shared	6.28	5.65	Yes	No	Yes	Yes	5	4
169	4x65	E2x52	Shared	6.93	6.24	Yes	Yes	No	No	6	5
170	E2	E2	Shared	48.91	30.545	Yes	Yes	Yes	Yes	4	4
171	E2	E2x51	Shared	15.62	13.685	Yes	Yes	No	No	4	3
172	5x35	E2	Shared	4.52	2.4	No	No	Yes	Yes	4	4
173	5x36	E2	Shared	21.67	16.21	No	No	Yes	Yes	5	4
174	5x34	E2	Shared	13.7	10.565	No	No	Yes	Yes	2	4
175	5x37	6x60	Shared	13.92	11.055	No	No	No	No	4	5
176	5x39	5x43	Shared	7.25	9.07	Yes	No	No	Yes	7	5
177	5x40	6x59	Shared	10.75	7.155	No	No	No	No	5	4
178	5x40	Lig	Shared	5.47	5.46	No	No	Yes	Yes	5	0
179	5x41	6x56	Shared	6.02	2.98	No	No	No	No	5	6
180	5x42	5x43	Shared	7.05	4.11	No	No	No	Yes	4	5
181	5x42	5x46	Shared	7.78	5.235	No	No	No	No	4	4
182	5x44	6x52	Shared	10.38	6.62	No	No	No	Yes	5	7
183	5x44	6x56	Shared	4.52	4.625	No	No	No	No	5	6
184	5x47	5x51	Shared	10.09	3.82	No	Yes	No	Yes	8	6
185	5x47	6x49	Shared	9.99	1.32	No	Yes	No	No	8	6
186	5x58	6x37	Shared	7.49	6.58	Yes	Yes	No	No	9	8
187	6x27	6x30	Shared	6.12	2.425	No	No	No	No	4	8
188	6x35	7x56	Shared	4.96	3.72	No	No	Yes	No	8	7
189	6x36	7x56	Shared	16.17	8.71	No	No	Yes	No	8	7
190	6x39	7x52	Shared	7.36	3.04	No	No	No	No	7	8
191	6x40	7x53	Shared	6.04	5.44	Yes	No	Yes	Yes	8	9
192	6x44	6x48	Shared	10.02	13.305	No	Yes	Yes	Yes	9	8
193	6x47	7x45	Shared	4.72	9.45	No	No	No	No	8	9
194	6x48	6x52	Shared	8.02	6.01	Yes	Yes	No	Yes	8	7
195	6x48	7x45	Shared	13.56	13.56	Yes	Yes	No	No	8	9
196	6x51	6x52	Shared	15	10.72	No	Yes	No	Yes	7	7
197	6x51	6x55	Shared	8.2	7.025	No	Yes	No	Yes	7	6
198	6x51	Lig	Shared	9.33	6.27	No	Yes	Yes	Yes	7	0
199	6x54	7x37	Shared	6.41	5.385	No	No	No	No	5	5
200	6x55	Lig	Shared	10.2	18.77	No	Yes	Yes	Yes	6	0
201	6x57	E3	Shared	6.48	9.265	No	No	Yes	Yes	4	4
202	E3	E3	Shared	8.39	4.895	Yes	Yes	Yes	Yes	4	4
203	7x45	7x49	Shared	12.59	7.49	No	No	No	No	9	9
204	1x57	2x44	Shared	4.23	0.855	Yes	No	No	No	7	6
205	1x39	2x61	Shared	4.15	8.3	No	No	No	No	6	7
206	1x43	1x47	Shared	4.15	3.46	No	No	No	No	6	6
207	3x27	3x31	Shared	4.15	1.385	No	No	No	No	5	5
208	3x21	E1x52	Shared	4.06	4.06	No	No	No	No	7	6
209	6x58	7x34	Shared	3.96	2.705	No	No	Yes	No	5	4
210	6x54	7x34	Shared	3.93	9.18	No	No	Yes	No	5	4
211	1x48	1x49	Shared	3.71	0.93	No	No	No	No	4	8
212	6x32	6x35	Shared	3.71	4.33	No	No	No	No	8	8
213	5x49	5x50	Shared	3.53	2.7	No	No	No	No	5	9
214	6x49	6x50	Shared	3.5	3.56	No	No	No	No	6	9
215	2x53	7x46	Shared	3.42	6.465	No	No	No	No	7	9
216	2x57	7x42	Shared	3.23	3.23	No	No	No	No	7	7
217	3x55	5x64	Shared	3.23	3.945	No	No	No	No	7	6
218	3x51	5x60	Shared	3.17	4.155	No	Yes	No	No	7	6
219	3x45	4x45	Shared	3.15	1.575	No	No	No	No	7	5
220	1x54	2x47	Shared	3	0.795	No	No	No	No	7	9
221	1x36	2x61	Shared	2.98	2.82	No	No	No	No	6	7
222	1x38	7x39	Shared	2.98	1.385	No	Yes	No	Yes	4	5
223	3x44	5x53	Shared	2.98	6.07	Yes	No	No	No	7	6
224	3x42	4x49	Shared	2.95	1.61	No	Yes	No	No	8	7
225	4x60	5x39	Shared	2.78	2.085	No	No	Yes	No	7	7
226	2x41	4x42	Shared	2.77	3.095	Yes	No	No	No	5	7
227	1x35	7x35	Shared	2.73	4.9	No	Yes	No	No	5	4
228	2x49	4x50	Shared	2.59	2.595	No	No	Yes	Yes	8	9
229	5x34	5x38	Shared	2.59	2.51	No	No	No	No	2	4
230	6x38	6x42	Shared	2.44	1.825	No	No	No	No	6	5
231	3x30	3x31	Shared	2.34	1.76	No	Yes	No	No	7	5
232	1x46	7x47	Shared	1.81	3.515	No	No	No	No	8	7
233	6x43	7x48	Shared	1.81	2.38	No	No	No	No	6	6
234	6x46	6x47	Shared	1.71	0.855	No	No	No	No	6	8
235	1x34	1x38	Shared	1.6	0.8	No	No	No	Yes	5	4
236	1x41	1x44	Shared	1.38	0.69	No	No	No	No	4	4
237	8x47	8x49	Shared	1.31	5.87	No	No	No	No	8	6
238	Lig	Lig	vasopressin-ot_on	0	23.05	Yes	Yes	Yes	Yes	0	0
239	7x38	Lig	vasopressin-ot_on	0	5.6	No	No	Yes	Yes	6	0
240	7x39	Lig	vasopressin-ot_on	0	3.69	No	Yes	Yes	Yes	5	0
241	2x60	Lig	vasopressin-ot_on	0	11.835	No	No	Yes	Yes	7	0
242	5x43	Lig	vasopressin-ot_on	0	4.095	No	Yes	Yes	Yes	5	0
243	6x58	Lig	vasopressin-ot_on	0	4.37	No	No	Yes	Yes	5	0
244	E2x51	Lig	vasopressin-ot_on	0	22.6	No	No	Yes	Yes	3	0
245	7x35	Lig	vasopressin-ot_on	0	6.995	No	No	Yes	Yes	4	0
246	1x35	Lig	vasopressin-ot_on	0	7.28	No	Yes	Yes	Yes	5	0
247	1x31	1x35	vasopressin-ot_on	0	3.98	No	Yes	No	Yes	5	5
248	1x35	7x39	vasopressin-ot_on	0	3.975	No	Yes	No	Yes	5	5
249	1x39	7x39	vasopressin-ot_on	0	3.46	No	No	No	Yes	6	5
250	1x43	2x58	vasopressin-ot_on	0	6.425	No	No	No	No	6	8
251	1x50	2x50	vasopressin-ot_on	0	9.425	No	No	No	Yes	9	9
252	1x50	2x51	vasopressin-ot_on	0	4.12	No	No	No	No	9	7
253	2x37	2x40	vasopressin-ot_on	0	4.835	No	No	No	Yes	8	9
254	2x38	3x49	vasopressin-ot_on	0	3.575	Yes	No	No	No	7	9
255	2x38	4x42	vasopressin-ot_on	0	4.63	Yes	No	No	No	7	7
256	2x40	8x50	vasopressin-ot_on	0	5.04	No	Yes	No	No	9	8
257	2x41	4x39	vasopressin-ot_on	0	3.74	Yes	No	No	No	5	4
258	2x45	3x42	vasopressin-ot_on	0	5.155	No	No	No	Yes	9	8
259	2x46	2x50	vasopressin-ot_on	0	4.75	No	No	No	Yes	9	9
260	2x46	3x42	vasopressin-ot_on	0	3.475	No	No	No	Yes	9	8
261	2x50	7x50	vasopressin-ot_on	0	4.025	No	Yes	No	No	9	9
262	2x53	2x56	vasopressin-ot_on	0	4.295	No	No	Yes	Yes	7	7
263	2x56	3x36	vasopressin-ot_on	0	10.875	Yes	Yes	No	No	7	6
264	2x60	3x32	vasopressin-ot_on	0	9.6	No	No	No	Yes	7	7
265	2x63	E1x50	vasopressin-ot_on	0	5.01	No	No	Yes	Yes	5	7
266	2x63	E2	vasopressin-ot_on	0	6.7	No	No	Yes	Yes	5	4
267	3x24	E1x50	vasopressin-ot_on	0	6.7	No	No	Yes	Yes	5	7
268	3x30	4x57	vasopressin-ot_on	0	6.995	No	Yes	No	No	7	7
269	3x30	4x59	vasopressin-ot_on	0	4.85	No	Yes	No	No	7	4
270	3x30	4x62	vasopressin-ot_on	0	5.5	No	Yes	No	No	7	5
271	3x37	5x43	vasopressin-ot_on	0	3.675	Yes	Yes	No	Yes	6	5
272	3x40	5x50	vasopressin-ot_on	0	3.53	No	No	No	No	8	9
273	3x43	7x49	vasopressin-ot_on	0	5.575	No	No	No	No	8	9
274	3x46	7x53	vasopressin-ot_on	0	7.78	No	No	Yes	Yes	8	9
275	3x50	5x58	vasopressin-ot_on	0	4.32	Yes	No	Yes	Yes	9	9
276	4x40	4x43	vasopressin-ot_on	0	13.33	No	No	No	Yes	5	3
277	5x37	6x59	vasopressin-ot_on	0	3.795	No	No	No	No	4	4
278	5x40	6x55	vasopressin-ot_on	0	3.43	No	No	No	Yes	5	6
279	5x461	6x48	vasopressin-ot_on	0	3.675	No	No	Yes	Yes	5	8
280	5x461	6x52	vasopressin-ot_on	0	5.24	No	No	No	Yes	5	7
281	5x47	6x48	vasopressin-ot_on	0	3.45	No	Yes	Yes	Yes	8	8
282	5x50	6x44	vasopressin-ot_on	0	3.53	No	No	No	Yes	9	9
283	5x51	6x44	vasopressin-ot_on	0	4.43	No	Yes	No	Yes	6	9
284	5x58	6x36	vasopressin-ot_on	0	3.835	Yes	Yes	No	No	9	8
285	5x58	6x40	vasopressin-ot_on	0	7.335	Yes	Yes	Yes	No	9	8
286	5x62	6x33	vasopressin-ot_on	0	6.09	No	Yes	No	No	5	8
287	6x32	7x56	vasopressin-ot_on	0	5.15	No	No	Yes	No	8	7
288	6x51	7x41	vasopressin-ot_on	0	8.32	No	Yes	No	No	7	7
289	6x55	7x38	vasopressin-ot_on	0	7.475	No	Yes	No	No	6	6
290	7x40	7x43	vasopressin-ot_on	0	4.845	No	No	No	No	7	5
291	7x49	7x53	vasopressin-ot_on	0	3.49	No	No	Yes	Yes	9	9
292	8x47	8x50	vasopressin-ot_on	0	6.18	No	No	No	No	8	8
293	8x51	8x52	vasopressin-ot_on	0	3.96	No	No	No	No	8	0
294	2x67	NT	vasopressin-ot_on	0	5.955	No	No	No	No	4	0
295	1x31	Lig	vasopressin-ot_on	0	5.465	No	Yes	Yes	Yes	5	0
296	1x49	7x51	vasopressin-ot_on	0	4.325	No	No	No	No	8	6
297	1x57	I1	vasopressin-ot_on	0	3.415	Yes	No	No	Yes	7	0
298	1x59	8x53	vasopressin-ot_on	0	7.56	No	No	No	No	0	0
299	1x60	2x40	vasopressin-ot_on	0	3.95	No	No	No	Yes	0	9
300	1x60	8x53	vasopressin-ot_on	0	3.49	No	No	No	No	0	0
301	4x41	I1	vasopressin-ot_on	0	4.76	No	No	No	Yes	7	0
302	2x40	8x49	vasopressin-ot_on	0	3.485	No	Yes	No	No	9	6
303	2x41	4x43	vasopressin-ot_on	0	3.695	Yes	No	No	Yes	5	3
304	3x51	3x55	vasopressin-ot_on	0	5.16	No	Yes	No	No	7	7
305	3x56	I2x52	vasopressin-ot_on	0	4.25	No	Yes	No	No	5	0
306	4x44	I2x56	vasopressin-ot_on	0	10.155	No	No	No	No	3	0
307	5x36	Lig	vasopressin-ot_on	0	8.175	No	No	Yes	Yes	5	0
308	6x57	6x61	vasopressin-ot_on	0	4.465	No	No	No	No	4	0
309	6x61	E3	vasopressin-ot_on	0	8.785	No	No	Yes	Yes	0	4
310	7x34	E3	vasopressin-ot_on	0	6.71	Yes	No	Yes	Yes	4	4
311	2x39	2x40	vasopressin-ot_on	0	3.315	No	No	No	Yes	8	9
312	1x53	7x54	vasopressin-ot_on	0	3.215	No	No	No	No	9	7
313	5x62	6x37	vasopressin-ot_on	0	3.2	No	Yes	No	No	5	8
314	2x40	I1	vasopressin-ot_on	0	3.175	No	Yes	No	Yes	9	0
315	6x47	7x43	vasopressin-ot_on	0	3.17	No	No	No	No	8	5
316	2x59	2x60	vasopressin-ot_on	0	3.16	No	No	No	No	4	7
317	2x59	3x32	vasopressin-ot_on	0	3.16	No	No	No	Yes	4	7
318	3x50	5x61	vasopressin-ot_on	0	3.135	Yes	No	No	No	9	8
319	1x36	2x65	vasopressin-ot_on	0	3.11	No	No	No	No	6	5
320	5x51	6x45	vasopressin-ot_on	0	3.1	No	Yes	No	No	6	6
321	3x52	I2x54	vasopressin-ot_on	0	3.085	No	Yes	No	No	3	0
322	5x65	6x33	vasopressin-ot_on	0	3.04	No	No	No	No	8	8
323	4x43	4x47	vasopressin-ot_on	0	3.035	No	Yes	No	No	3	3
324	1x30	1x33	vasopressin-ot_on	0	3.035	No	No	No	No	3	5
325	6x53	6x57	vasopressin-ot_on	0	3.005	No	No	No	No	5	4
326	3x24	3x28	vasopressin-ot_on	0	2.98	No	No	No	No	5	6
327	3x49	3x52	vasopressin-ot_on	0	2.98	No	No	No	Yes	9	3
328	4x38	4x43	vasopressin-ot_on	0	2.98	No	No	No	Yes	4	3
329	5x65	6x30	vasopressin-ot_on	0	2.95	No	No	No	No	8	8
330	2x39	2x43	vasopressin-ot_on	0	2.915	No	No	No	No	8	7
331	1x61	I1	vasopressin-ot_on	0	2.815	No	No	No	Yes	0	0
332	1x32	NT	vasopressin-ot_on	0	2.765	No	No	No	No	5	0
333	3x41	4x53	vasopressin-ot_on	0	2.69	No	No	No	No	6	8
334	Lig	NT	vasopressin-ot_on	0	2.665	Yes	Yes	No	No	0	0
335	5x47	5x48	vasopressin-ot_on	0	2.57	No	Yes	No	No	8	5
336	7x31	E3	vasopressin-ot_on	0	2.57	No	No	Yes	Yes	2	4
337	3x52	3x56	vasopressin-ot_on	0	2.53	No	Yes	No	Yes	3	5
338	5x66	6x34	vasopressin-ot_on	0	2.45	No	No	No	No	6	7
339	1x46	7x46	vasopressin-ot_on	0	2.425	No	No	No	No	8	9
340	1x64	I1	vasopressin-ot_on	0	2.385	No	No	No	Yes	0	0
341	6x43	7x52	vasopressin-ot_on	0	2.345	No	No	No	No	6	8
342	5x63	5x67	vasopressin-ot_on	0	2.34	No	No	No	No	4	5
343	1x31	7x32	vasopressin-ot_on	0	2.325	No	Yes	No	No	5	2
344	6x58	7x29	vasopressin-ot_on	0	2.295	No	No	No	No	5	4
345	5x62	5x66	vasopressin-ot_on	0	2.265	No	Yes	No	No	5	6
346	2x62	2x66	vasopressin-ot_on	0	2.21	No	No	No	No	4	6
347	8x53	8x56	vasopressin-ot_on	0	2.155	No	No	No	No	0	0
348	3x52	3x53	vasopressin-ot_on	0	2.075	No	Yes	No	No	3	8
349	5x64	5x67	vasopressin-ot_on	0	2.035	No	No	No	No	6	5
350	1x28	1x30	vasopressin-ot_on	0	2.035	No	No	No	No	5	3
351	4x63	4x64	vasopressin-ot_on	0	1.99	No	No	Yes	No	5	5
352	2x45	2x48	vasopressin-ot_on	0	1.97	No	No	No	No	9	6
353	2x52	4x50	vasopressin-ot_on	0	1.84	No	No	Yes	Yes	6	9
354	2x53	3x35	vasopressin-ot_on	0	1.84	No	No	No	No	7	6
355	1x53	7x50	vasopressin-ot_on	0	1.765	No	No	No	No	9	9
356	5x55	6x41	vasopressin-ot_on	0	1.7	No	No	Yes	No	4	8
357	1x46	2x54	vasopressin-ot_on	0	1.695	No	No	No	No	8	7
358	1x52	7x54	vasopressin-ot_on	0	1.62	No	No	No	No	6	7
359	6x42	6x46	vasopressin-ot_on	0	1.49	No	No	No	No	5	6
360	6x39	6x40	vasopressin-ot_on	0	1.47	No	No	Yes	No	7	8
361	4x44	4x45	vasopressin-ot_on	0	1.44	No	No	No	No	3	5
362	1x38	1x39	vasopressin-ot_on	0	1.385	No	Yes	No	No	4	6
363	1x38	7x36	vasopressin-ot_on	0	1.385	No	Yes	No	No	4	5
364	3x44	3x48	vasopressin-ot_on	0	1.385	Yes	No	No	No	7	6
365	4x55	4x56	vasopressin-ot_on	0	1.385	No	No	No	No	3	5
366	4x48	4x52	vasopressin-ot_on	0	1.31	No	No	No	No	4	4
367	1x55	8x51	vasopressin-ot_on	0	1.22	No	No	No	No	4	8
368	1x55	1x58	vasopressin-ot_on	0	1.215	No	No	No	No	4	2
369	7x51	7x54	vasopressin-ot_on	0	1.165	No	No	No	No	6	7
370	I2x55	I2x56	vasopressin-ot_on	0	1.13	No	No	No	No	0	0
371	1x62	1x63	vasopressin-ot_on	0	1.065	No	No	No	No	0	0
372	7x31	7x33	vasopressin-ot_on	0	1.015	No	No	No	No	2	5
373	5x59	5x62	vasopressin-ot_on	0	0.93	No	No	No	Yes	3	5
374	4x52	4x55	vasopressin-ot_on	0	0.92	No	No	No	No	4	3
375	1x51	1x54	vasopressin-ot_on	0	0.855	No	No	No	No	3	7
376	5x52	5x53	vasopressin-ot_on	0	0.855	No	No	No	No	3	6
377	6x27	6x29	vasopressin-ot_on	0	0.855	No	No	No	No	4	6
378	5x56	5x57	vasopressin-ot_on	0	0.845	No	No	No	No	4	6
379	1x40	1x44	vasopressin-ot_on	0	0.795	No	No	No	No	4	4
380	I2x56	I2x57	vasopressin-ot_on	0	0.795	No	No	No	No	0	0
381	5x51	6x41	vasopressin-ot_on	0	0.795	No	Yes	Yes	No	6	8
382	1x56	8x54	vasopressin-ot_on	0	0.79	No	No	No	No	7	0
383	3x22	3x23	vasopressin-ot_on	0	0.77	No	No	No	No	4	3
384	6x32	8x48	vasopressin-ot_on	0	0.765	No	No	No	No	8	5
385	1x63	1x64	vasopressin-ot_on	0	0.75	No	No	No	No	0	0
386	4x51	4x55	vasopressin-ot_on	0	0.745	No	No	No	No	4	3
387	5x45	5x49	vasopressin-ot_on	0	0.745	No	No	No	No	5	5
388	3x56	I2x50	vasopressin-ot_on	0	0.72	No	Yes	No	No	5	0
389	6x31	6x35	vasopressin-ot_on	0	0.69	No	No	No	No	6	8
390	7x30	Lig	vasopressin-ot_on	0	0.665	No	No	Yes	Yes	4	0

Orange: nodes, hubs and links specific of vasopressin-ot_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of vasopressin-ot_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	vasopressin-ot_off Avg Int. Strength	vasopressin-ot_on Avg Int. Strength	vasopressin-ot_off Num Of Links	vasopressin-ot_on Num Of Links	ConSurf
1	1x57	vasopressin-ot_off	2.7575	2.135	4	2	7
2	I1x51	vasopressin-ot_off	9.154	0	5	0	7
3	2x38	vasopressin-ot_off	6.7925	4.1025	4	2	7
4	2x41	vasopressin-ot_off	6.47	3.51	4	3	5
5	2x42	vasopressin-ot_off	5.935	7.12667	6	3	8
6	3x29	vasopressin-ot_off	8.646	10.2425	5	2	4
7	3x33	vasopressin-ot_off	8.8625	6.76333	4	3	5
8	3x44	vasopressin-ot_off	4.945	3.7275	4	2	7
9	3x50	vasopressin-ot_off	7.615	3.7275	6	2	9
10	3x54	vasopressin-ot_off	5.125	1.47	4	1	8
11	I2	vasopressin-ot_off	6.588	0.79	5	1	7
12	4x64	vasopressin-ot_off	7.535	3.80333	4	3	5
13	5x39	vasopressin-ot_off	7.014	6.35	5	3	7
14	6x40	vasopressin-ot_off	5.14	4.74833	4	3	8
15	6x41	vasopressin-ot_off	6.06	1.2475	4	2	8
16	7x34	vasopressin-ot_off	3.1975	6.19833	4	3	4
17	7x56	vasopressin-ot_off	7.765	5.86	4	3	7
18	2x56	Shared	12.8925	8.402	4	5	7
19	E1x50	Shared	6.135	5.761	4	5	7
20	3x37	Shared	6.442	6.136	5	5	6
21	4x50	Shared	4.4075	3.11625	4	4	9
22	4x61	Shared	7.57	7.61875	5	4	6
23	4x65	Shared	8.408	7.95625	5	4	6
24	E2	Shared	16.4092	13.2732	12	11	4
25	5x58	Shared	8.3925	5.333	4	5	9
26	6x48	Shared	8.84333	8	6	5	8
27	E3	Shared	6.2075	6.18667	4	6	4
28	7x53	Shared	7.5775	5.07875	4	4	9
29	Lig	Shared	10.888	9.2795	10	20	0
30	1x31	vasopressin-ot_on	9.61	4.48	1	4	5
31	1x35	vasopressin-ot_on	6.56667	4.702	3	5	5
32	1x38	vasopressin-ot_on	2.55	1.23875	3	4	4
33	2x40	vasopressin-ot_on	2.44	3.96667	1	6	9
34	2x50	vasopressin-ot_on	4.87333	6.438	3	5	9
35	3x30	vasopressin-ot_on	5.67667	4.758	3	5	7
36	3x32	vasopressin-ot_on	11.9933	5.826	3	5	7
37	3x42	vasopressin-ot_on	3.755	3.4325	2	4	8
38	3x51	vasopressin-ot_on	5.12	4.71875	3	4	7
39	3x52	vasopressin-ot_on	5.54	2.6675	1	4	3
40	3x56	vasopressin-ot_on	13.26	2.0725	1	4	5
41	4x43	vasopressin-ot_on	3.2	5.76	1	4	3
42	5x43	vasopressin-ot_on	6.67	5.2375	3	4	5
43	5x47	vasopressin-ot_on	10.04	2.79	2	4	8
44	5x51	vasopressin-ot_on	10.09	3.03625	1	4	6
45	5x62	vasopressin-ot_on	0	3.12125	0	4	5
46	6x44	vasopressin-ot_on	8.9	6.28	2	4	9
47	6x51	vasopressin-ot_on	10.8433	8.08375	3	4	7
48	6x52	vasopressin-ot_on	11.1333	7.1475	3	4	7
49	6x55	vasopressin-ot_on	7.30333	9.175	3	4	6
50	7x39	vasopressin-ot_on	3.63	3.1275	2	4	5
51	I1	vasopressin-ot_on	0	3.31	0	5	0

Orange: nodes, hubs and links specific of vasopressin-ot_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of vasopressin-ot_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	vasopressin-ot_off Recurrence	vasopressin-ot_on Recurrence	vasopressin-ot_off Hub1?	vasopressin-ot_on Hub1?	vasopressin-ot_off Hub2?	vasopressin-ot_on Hub2?	ConSurf1	ConSurf2
1	1x35	1x39	vasopressin-ot_off	22.7522	0	No	Yes	No	No	5	6
2	1x35	7x35	vasopressin-ot_off	16.4069	0.102191	No	Yes	No	No	5	4
3	7x35	7x39	vasopressin-ot_off	14.8095	0	No	No	No	Yes	4	5
4	1x38	7x39	vasopressin-ot_off	13.1848	4.78029	No	Yes	No	Yes	4	5
5	1x39	7x38	vasopressin-ot_off	28.9219	0	No	No	No	No	6	6
6	2x60	7x38	vasopressin-ot_off	30.1789	0	No	No	No	No	7	6
7	2x56	2x60	vasopressin-ot_off	31.7049	0	Yes	Yes	No	No	7	7
8	6x48	Lig	vasopressin-ot_off	65.7701	0	Yes	Yes	Yes	Yes	8	0
9	6x40	7x49	vasopressin-ot_off	46.5309	0	Yes	No	No	No	8	9
10	1x53	7x53	vasopressin-ot_off	18.4543	0	No	No	Yes	Yes	9	9
11	1x53	2x47	vasopressin-ot_off	10.1987	4.83706	No	No	No	No	9	9
12	6x47	7x45	vasopressin-ot_off	23.2902	9.70251	No	No	No	No	8	9
13	6x46	6x47	vasopressin-ot_off	22.7028	4.89951	No	No	No	No	6	8
14	6x45	6x46	vasopressin-ot_off	22.3186	0	No	No	No	No	6	6
15	6x41	6x45	vasopressin-ot_off	22.2802	0	Yes	No	No	No	8	6
16	5x58	6x41	vasopressin-ot_off	78.9933	0	Yes	Yes	Yes	No	9	8
17	3x46	6x37	vasopressin-ot_off	36.7384	0	No	No	No	No	8	8
18	2x38	2x42	vasopressin-ot_off	10.0944	0	Yes	No	Yes	No	7	8
19	3x43	6x40	vasopressin-ot_off	35.1026	0	No	No	Yes	No	8	8
20	3x43	6x41	vasopressin-ot_off	34.7184	0	No	No	Yes	No	8	8
21	3x50	6x37	vasopressin-ot_off	62.054	0	Yes	No	No	No	9	8
22	3x50	I1x51	vasopressin-ot_off	54.029	0	Yes	No	Yes	No	9	7
23	2x38	I1x51	vasopressin-ot_off	10.3579	0	Yes	No	Yes	No	7	7
24	I1x51	I2	vasopressin-ot_off	45.9106	0	Yes	No	Yes	No	7	7
25	2x41	2x42	vasopressin-ot_off	20.5127	0	Yes	No	Yes	No	5	8
26	2x41	2x45	vasopressin-ot_off	16.3629	0	Yes	No	No	No	5	9
27	2x45	4x50	vasopressin-ot_off	14.0905	0	No	No	Yes	Yes	9	9
28	3x34	4x57	vasopressin-ot_off	13.5196	1.6748	No	No	No	No	6	7
29	3x30	3x34	vasopressin-ot_off	10.1713	0	No	Yes	No	No	7	6
30	4x61	4x64	vasopressin-ot_off	22.3021	0	Yes	Yes	Yes	No	6	5
31	4x64	E2	vasopressin-ot_off	29.4324	6.12013	Yes	No	Yes	Yes	5	4
32	E1x49	E1x51	vasopressin-ot_off	12.3779	8.5784	No	No	No	No	5	3
33	4x65	Lig	vasopressin-ot_off	10.5061	0	Yes	Yes	Yes	Yes	6	0
34	4x61	5x39	vasopressin-ot_off	26.6989	1.82241	Yes	Yes	Yes	No	6	7
35	5x39	E2	vasopressin-ot_off	34.7843	0	Yes	No	Yes	Yes	7	4
36	3x29	Lig	vasopressin-ot_off	11.796	0	Yes	No	Yes	Yes	4	0
37	E1x50	E1x52	vasopressin-ot_off	11.0605	5.70569	Yes	Yes	No	No	7	6
38	3x22	E2	vasopressin-ot_off	15.8305	7.86306	No	No	Yes	Yes	4	4
39	3x22	3x26	vasopressin-ot_off	12.3779	2.86704	No	No	No	No	4	6
40	3x33	5x43	vasopressin-ot_off	19.1733	0	Yes	No	No	Yes	5	5
41	5x39	5x43	vasopressin-ot_off	17.6693	2.68536	Yes	No	No	Yes	7	5
42	3x37	3x41	vasopressin-ot_off	55.6867	3.1509	Yes	Yes	No	No	6	6
43	3x41	3x44	vasopressin-ot_off	55.6812	0	No	No	Yes	No	6	7
44	3x44	5x54	vasopressin-ot_off	55.6153	0	Yes	No	No	No	7	8
45	3x47	5x54	vasopressin-ot_off	27.1435	1.64074	No	No	No	No	8	8
46	6x30	I2	vasopressin-ot_off	33.4285	0	No	No	Yes	No	8	7
47	3x54	6x30	vasopressin-ot_off	29.0372	0	Yes	No	No	No	8	8
48	3x54	5x61	vasopressin-ot_off	13.7995	1.63506	Yes	No	No	No	8	8
49	5x44	6x52	vasopressin-ot_off	15.6329	4.93358	No	No	No	Yes	5	7
50	6x55	Lig	vasopressin-ot_off	16.061	0.709663	No	Yes	Yes	Yes	6	0
51	6x55	7x34	vasopressin-ot_off	15.3694	0	No	Yes	Yes	No	6	4
52	6x54	7x34	vasopressin-ot_off	11.0495	3.19632	No	No	Yes	No	5	4
53	6x40	7x52	vasopressin-ot_off	13.8654	0	Yes	No	No	No	8	8
54	6x39	7x52	vasopressin-ot_off	10.2536	4.84842	No	No	No	No	7	8
55	5x54	6x41	vasopressin-ot_off	29.4324	0	No	No	Yes	No	8	8
56	3x47	5x58	vasopressin-ot_off	26.6604	2.97491	No	No	Yes	Yes	8	9
57	2x56	Lig	Shared	38.8242	52.6456	Yes	Yes	Yes	Yes	7	0
58	6x48	7x45	Shared	70.2492	100	Yes	Yes	No	No	8	9
59	7x45	7x49	Shared	47.98	95.708	No	No	No	No	9	9
60	6x40	7x53	Shared	21.5391	53.6675	Yes	No	Yes	Yes	8	9
61	5x58	6x37	Shared	100	15.2322	Yes	Yes	No	No	9	8
62	2x42	3x46	Shared	33.2089	31.7588	Yes	No	No	No	8	8
63	4x61	Lig	Shared	31.6445	14.9313	Yes	Yes	Yes	Yes	6	0
64	3x33	4x61	Shared	43.3308	12.9272	Yes	No	Yes	Yes	5	6
65	3x33	4x57	Shared	15.1608	16.2882	Yes	No	No	No	5	7
66	E1x49	E2	Shared	15.8415	11.0878	No	No	Yes	Yes	5	4
67	3x33	3x37	Shared	55.9062	11.3716	Yes	No	Yes	Yes	5	6
68	6x48	6x52	Shared	13.1079	89.6219	Yes	Yes	No	Yes	8	7
69	1x39	7x39	vasopressin-ot_on	0	11.1616	No	No	No	Yes	6	5
70	7x39	Lig	vasopressin-ot_on	0	16.5096	No	Yes	Yes	Yes	5	0
71	2x53	7x46	vasopressin-ot_on	1.31738	43.3859	No	No	No	No	7	9
72	2x53	2x56	vasopressin-ot_on	0	45.9521	No	No	Yes	Yes	7	7
73	2x50	7x46	vasopressin-ot_on	3.93018	35.415	No	Yes	No	No	9	9
74	2x50	7x50	vasopressin-ot_on	0	15.4593	No	Yes	No	No	9	9
75	1x53	7x50	vasopressin-ot_on	0	14.0456	No	No	No	No	9	9
76	2x39	2x40	vasopressin-ot_on	0	27.0978	No	No	No	Yes	8	9
77	2x39	2x43	vasopressin-ot_on	0	28.5171	No	No	No	No	8	7
78	2x43	7x53	vasopressin-ot_on	1.14722	29.7093	No	No	Yes	Yes	7	9
79	7x49	7x53	vasopressin-ot_on	0	94.1864	No	No	Yes	Yes	9	9
80	6x51	6x52	vasopressin-ot_on	6.4332	91.3421	No	Yes	No	Yes	7	7
81	6x51	Lig	vasopressin-ot_on	6.42222	87.5326	No	Yes	Yes	Yes	7	0
82	2x38	3x49	vasopressin-ot_on	0	12.1835	Yes	No	No	No	7	9
83	2x42	3x49	vasopressin-ot_on	2.07487	22.8284	Yes	No	No	No	8	9
84	3x46	7x53	vasopressin-ot_on	0	32.9056	No	No	Yes	Yes	8	9
85	2x38	4x42	vasopressin-ot_on	0	10.6393	Yes	No	No	No	7	7
86	2x46	3x42	vasopressin-ot_on	0	13.8924	No	No	No	Yes	9	8
87	2x46	2x50	vasopressin-ot_on	0	15.4196	No	No	No	Yes	9	9
88	3x30	4x57	vasopressin-ot_on	0	13.1202	No	Yes	No	No	7	7
89	5x36	E2	vasopressin-ot_on	4.13327	27.4668	No	No	Yes	Yes	5	4
90	5x36	Lig	vasopressin-ot_on	0	28.3297	No	No	Yes	Yes	5	0
91	E1x50	E2	vasopressin-ot_on	9.28203	21.886	Yes	Yes	Yes	Yes	7	4
92	E2	E2x51	vasopressin-ot_on	3.76551	27.0183	Yes	Yes	No	No	4	3
93	E2x51	Lig	vasopressin-ot_on	0	27.8983	No	No	Yes	Yes	3	0
94	3x37	5x43	vasopressin-ot_on	0	10.0261	Yes	Yes	No	Yes	6	5
95	5x43	Lig	vasopressin-ot_on	0	10.0488	No	Yes	Yes	Yes	5	0
96	3x37	5x461	vasopressin-ot_on	1.72357	19.74	Yes	Yes	No	No	6	5
97	6x44	6x48	vasopressin-ot_on	3.266	14.1081	No	Yes	Yes	Yes	9	8
98	3x51	5x61	vasopressin-ot_on	9.30398	18.7237	No	Yes	No	No	7	8
99	3x50	5x61	vasopressin-ot_on	0	21.7214	Yes	No	No	No	9	8
100	3x50	5x58	vasopressin-ot_on	0	22.8795	Yes	No	Yes	Yes	9	9
101	5x58	6x40	vasopressin-ot_on	0	47.7461	Yes	Yes	Yes	No	9	8
102	5x47	6x48	vasopressin-ot_on	0	12.5525	No	Yes	Yes	Yes	8	8
103	5x62	6x37	vasopressin-ot_on	0	13.6823	No	Yes	No	No	5	8
104	6x58	7x34	vasopressin-ot_on	1.59732	13.2508	No	No	Yes	No	5	4
105	6x58	Lig	vasopressin-ot_on	0	15.482	No	No	Yes	Yes	5	0
106	2x40	I1	vasopressin-ot_on	0	10.5711	No	Yes	No	Yes	9	0
107	5x461	6x48	vasopressin-ot_on	0	18.8543	No	No	Yes	Yes	5	8

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
1x28	1x31	Shared	9.61	6.15	0	0	2	1
1x35	2x64	Shared	12.99	3.375	0	1	1	2
2x56	2x60	vasopressin-ot_off	5.12	0	1	1	1	1
2x56	3x32	Shared	11.52	3.84	1	1	1	1
2x56	7x42	Shared	4.33	7.22	1	1	1	2
2x56	Lig	Shared	30.6	15.78	1	1	1	0
2x60	7x38	vasopressin-ot_off	6.8	0	0	1	1	1
3x29	3x32	Shared	8.14	7.455	1	0	1	1
3x29	4x65	Shared	17.37	13.03	1	0	1	1
3x29	E2x50	vasopressin-ot_off	6.47	0	1	0	1	2
3x29	Lig	vasopressin-ot_off	9.73	0	1	0	1	0
3x32	Lig	Shared	16.32	5.075	1	1	1	0
3x33	3x37	Shared	6.09	4.9	0	0	2	2
3x33	4x61	Shared	14.64	9.095	0	0	2	1
3x33	5x43	vasopressin-ot_off	5.71	0	0	0	2	1
3x36	6x48	vasopressin-ot_off	5.82	0	1	0	1	1
3x36	Lig	vasopressin-ot_off	8.67	0	1	0	1	0
3x37	5x461	Shared	7.87	4.515	0	0	2	2
4x61	4x64	vasopressin-ot_off	5.49	0	1	1	1	2
4x61	4x65	Shared	5.86	8.785	1	1	1	1
4x61	5x39	Shared	6.76	7.895	1	1	1	2
4x61	Lig	Shared	5.1	4.7	1	1	1	0
4x64	4x65	Shared	6.28	3.77	1	1	2	1
4x64	E2	Shared	6.28	5.65	1	1	2	2
4x64	5x39	vasopressin-ot_off	12.09	0	1	1	2	2
4x65	E2x52	Shared	6.93	6.24	1	0	1	2
4x65	Lig	vasopressin-ot_off	5.6	0	1	0	1	0
E2	E2	Shared	48.91	30.545	1	1	2	2
E2	E2x51	Shared	15.62	13.685	1	1	2	1
5x36	E2	Shared	21.67	16.21	0	1	1	2
5x39	E2	vasopressin-ot_off	6.19	0	1	0	2	2
5x39	5x43	Shared	7.25	9.07	1	0	2	1
5x40	6x59	Shared	10.75	7.155	0	1	1	2
5x40	Lig	Shared	5.47	5.46	0	1	1	0
5x42	5x43	Shared	7.05	4.11	0	0	2	1
6x44	6x48	Shared	10.02	13.305	0	1	2	1
6x48	6x52	Shared	8.02	6.01	1	1	1	2
6x48	7x41	vasopressin-ot_off	7.78	0	1	1	1	2
6x48	7x45	Shared	13.56	13.56	1	1	1	2
6x48	Lig	vasopressin-ot_off	7.86	0	1	1	1	0
6x51	6x52	Shared	15	10.72	1	1	1	2
6x51	6x55	Shared	8.2	7.025	1	1	1	1
6x51	Lig	Shared	9.33	6.27	1	1	1	0
6x55	Lig	Shared	10.2	18.77	1	1	1	0
E3	E3	Shared	8.39	4.895	0	1	2	2
7x29	7x32	vasopressin-ot_off	10.71	0	0	0	2	2
7x35	7x39	vasopressin-ot_off	4.28	0	0	1	1	1
1x35	1x39	vasopressin-ot_off	3.98	0	0	1	1	2
6x58	7x34	Shared	3.96	2.705	0	1	1	2
2x59	3x28	vasopressin-ot_off	3.53	0	0	1	2	2
6x55	7x34	vasopressin-ot_off	3.51	0	1	1	1	2
1x38	7x39	Shared	2.98	1.385	0	1	2	1
1x39	7x38	vasopressin-ot_off	2.83	0	0	1	2	1
1x35	7x35	Shared	2.73	4.9	0	1	1	1
7x30	E3	vasopressin-ot_off	1.57	0	0	0	1	2
3x28	3x29	vasopressin-ot_off	1.52	0	0	0	2	1
7x38	Lig	vasopressin-ot_on	0	5.6	0	1	1	0
7x39	Lig	vasopressin-ot_on	0	3.69	0	1	1	0
2x60	Lig	vasopressin-ot_on	0	11.835	0	1	1	0
5x43	Lig	vasopressin-ot_on	0	4.095	0	1	1	0
6x58	Lig	vasopressin-ot_on	0	4.37	0	1	1	0
E2x51	Lig	vasopressin-ot_on	0	22.6	0	1	1	0
7x35	Lig	vasopressin-ot_on	0	6.995	0	1	1	0
1x35	Lig	vasopressin-ot_on	0	7.28	0	1	1	0
1x31	1x35	vasopressin-ot_on	0	3.98	0	1	1	1
1x35	7x39	vasopressin-ot_on	0	3.975	0	1	1	1
1x39	7x39	vasopressin-ot_on	0	3.46	0	1	2	1
2x53	2x56	vasopressin-ot_on	0	4.295	0	0	2	1
2x56	3x36	vasopressin-ot_on	0	10.875	1	1	1	1
2x60	3x32	vasopressin-ot_on	0	9.6	0	1	1	1
3x37	5x43	vasopressin-ot_on	0	3.675	0	0	2	1
5x40	6x55	vasopressin-ot_on	0	3.43	0	1	1	1
5x461	6x48	vasopressin-ot_on	0	3.675	0	1	2	1
5x461	6x52	vasopressin-ot_on	0	5.24	0	1	2	2
5x47	6x48	vasopressin-ot_on	0	3.45	0	0	2	1
6x51	7x41	vasopressin-ot_on	0	8.32	1	1	1	2
6x55	7x38	vasopressin-ot_on	0	7.475	1	1	1	1
2x67	NT	vasopressin-ot_on	0	5.955	0	0	2	1
1x31	Lig	vasopressin-ot_on	0	5.465	0	1	1	0
5x36	Lig	vasopressin-ot_on	0	8.175	0	1	1	0
7x34	E3	vasopressin-ot_on	0	6.71	0	1	2	2
2x59	2x60	vasopressin-ot_on	0	3.16	0	1	2	1
2x59	3x32	vasopressin-ot_on	0	3.16	0	1	2	1
1x32	NT	vasopressin-ot_on	0	2.765	0	0	2	1
Lig	NT	vasopressin-ot_on	0	2.665	1	1	0	1
1x31	7x32	vasopressin-ot_on	0	2.325	0	1	1	2
6x58	7x29	vasopressin-ot_on	0	2.295	0	1	1	2
1x38	1x39	vasopressin-ot_on	0	1.385	0	1	2	2
7x30	Lig	vasopressin-ot_on	0	0.665	0	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	vasopressin-ot_off	ot_off
	vasopressin-ot_on	ot_on v2_on

Network Difference
Value	vasopressin-ot_off	vasopressin-ot_on
I_min	4.28	3.375
Number of Linked Nodes	218	254
Number of Specific Nodes	6 (2.75%)	42 (16.54%)
Number of Shared Nodes	212 (97.25%)	212 (83.46%)
Number of Links	237	280
Number of Specific Links	110 (46.41%)	153 (54.64%)
Number of Shared Links	127 (53.59%)	127 (45.36%)
Number of Hubs	29	34
Number of Specific Hubs	17 (58.62%)	22 (64.71%)
Number of Shared Hubs	12 (41.38%)	12 (35.29%)
Average % Shared Neighbours (Jaccard)	32.82
Average % Shared Neighbours (Otsuka)	41.85
Average % Shared Neighbours (Overlap Coefficient)	52.01
Average % Shared Cliques (k3-6)	76.61
Graphlets Similarity	0.545992

Paths Difference
Value	vasopressin-ot_off	vasopressin-ot_on
Number Of Nodes in MetaPath	64	49
Specific Nodes in MetaPath	36 (56.25%)	21 (42.86%)
Shared Nodes in MetaPath	212 (97.25%)	212 (97.25%)
Number Of Links MetaPath	68	51
Specific Links in MetaPath	56 (82.35%)	39 (76.47%)
Shared Links in MetaPath	127 (53.59%)	127 (53.59%)
Number of Shortest Paths	37352	37897
Length Of Smallest Path	3	3
Average Path Length	13.0937	11.5664
Length of Longest Path	30	27
Minimum Path Strength	1.46	0.7425
Average Path Strength	7.24179	6.51027
Maximum Path Strength	18.645	16.4183
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.905957	0.90996
Maximum Path Correlation	0.99	0.99
Minimum % Of Corr. Nodes	3.84615	4.54545
Average % Of Corr. Nodes	37.7285	44.1157
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	45.9833	43.2655
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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