| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9YDP | A | Peptide | Opioid | DOP | Homo Sapiens | DADLE | - | chim(NtGi1L-Gs-CtGi1)/Beta1/Gamma2 | 1.95 | 2025-12-10 | 10.1101/2025.10.16.682975 |
|
A 2D representation of the interactions of DLE in 9YDP
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?2 | L:L:Y1 | 17.89 | 3 | Yes | Yes | 0 | 0 | 1 | 2 | | L:L:Y1 | R:R:I277 | 3.63 | 3 | Yes | No | 0 | 5 | 2 | 2 | | L:L:Y1 | R:R:V281 | 6.31 | 3 | Yes | No | 0 | 6 | 2 | 2 | | L:L:?2 | L:L:G3 | 6.96 | 3 | Yes | No | 0 | 0 | 1 | 2 | | L:L:?2 | L:L:?5 | 13.49 | 3 | Yes | No | 0 | 0 | 1 | 0 | | L:L:?2 | R:R:I277 | 4.36 | 3 | Yes | No | 0 | 5 | 1 | 2 | | L:L:?2 | R:R:I304 | 8.71 | 3 | Yes | Yes | 0 | 5 | 1 | 2 | | L:L:G3 | R:R:I304 | 3.53 | 3 | No | Yes | 0 | 5 | 2 | 2 | | L:L:?5 | R:R:K214 | 7.37 | 0 | No | Yes | 0 | 5 | 0 | 1 | | L:L:?5 | R:R:W284 | 19.83 | 0 | No | No | 0 | 4 | 0 | 1 | | R:R:D210 | R:R:K214 | 9.68 | 0 | No | Yes | 4 | 5 | 2 | 1 | | R:R:K214 | R:R:V281 | 7.59 | 0 | Yes | No | 5 | 6 | 1 | 2 | | R:R:I289 | R:R:W284 | 5.87 | 25 | Yes | No | 1 | 4 | 2 | 1 | | R:R:R291 | R:R:W284 | 27.99 | 25 | No | No | 1 | 4 | 2 | 1 | | R:R:I289 | R:R:R291 | 3.76 | 25 | Yes | No | 1 | 1 | 2 | 2 | | R:R:K214 | R:R:T285 | 3 | 0 | Yes | No | 5 | 4 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 13.56 | | Average Nodes In Shell | 13.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 16.00 | | Average Links Mediated by Hubs In Shell | 14.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9YDQ | A | Peptide | Opioid | DOP | Homo Sapiens | DADLE | MIPS3614 | chim(NtGi1L-Gs-CtGi1)/Beta1/Gamma2 | 1.94 | 2025-12-10 | 10.1101/2025.10.16.682975 |
|
A 2D representation of the interactions of DLE in 9YDQ
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?2 | L:L:Y1 | 16.69 | 2 | Yes | Yes | 0 | 0 | 1 | 2 | | L:L:Y1 | R:R:I277 | 3.63 | 2 | Yes | Yes | 0 | 5 | 2 | 2 | | L:L:Y1 | R:R:V281 | 3.79 | 2 | Yes | No | 0 | 6 | 2 | 2 | | L:L:?2 | L:L:G3 | 6.96 | 2 | Yes | No | 0 | 0 | 1 | 2 | | L:L:?2 | L:L:?5 | 12.26 | 2 | Yes | No | 0 | 0 | 1 | 0 | | L:L:?2 | R:R:I277 | 5.81 | 2 | Yes | Yes | 0 | 5 | 1 | 2 | | L:L:?2 | R:R:I304 | 8.71 | 2 | Yes | Yes | 0 | 5 | 1 | 2 | | L:L:?5 | R:R:K214 | 11.05 | 0 | No | Yes | 0 | 5 | 0 | 1 | | L:L:?5 | R:R:W284 | 18.84 | 0 | No | Yes | 0 | 4 | 0 | 1 | | R:R:D210 | R:R:K214 | 9.68 | 0 | No | Yes | 4 | 5 | 2 | 1 | | R:R:K214 | R:R:V281 | 7.59 | 0 | Yes | No | 5 | 6 | 1 | 2 | | R:R:K214 | R:R:T285 | 3 | 0 | Yes | No | 5 | 4 | 1 | 2 | | R:R:F280 | R:R:W284 | 3.01 | 0 | Yes | Yes | 5 | 4 | 2 | 1 | | R:R:I289 | R:R:W284 | 4.7 | 10 | Yes | Yes | 1 | 4 | 2 | 1 | | R:R:R291 | R:R:W284 | 28.99 | 10 | Yes | Yes | 1 | 4 | 2 | 1 | | R:R:I289 | R:R:R291 | 3.76 | 10 | Yes | Yes | 1 | 1 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 14.05 | | Average Nodes In Shell | 14.00 | | Average Hubs In Shell | 9.00 | | Average Links In Shell | 16.00 | | Average Links Mediated by Hubs In Shell | 16.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9YDR | A | Peptide | Opioid | DOP | Homo Sapiens | DADLE | MIPS3983 | chim(NtGi1L-Gs-CtGi1)/Beta1/Gamma2 | 2.14 | 2025-12-10 | 10.1101/2025.10.16.682975 |
|
A 2D representation of the interactions of DLE in 9YDR
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?2 | L:L:Y1 | 17.89 | 2 | Yes | Yes | 0 | 0 | 1 | 2 | | L:L:Y1 | R:R:I277 | 3.63 | 2 | Yes | No | 0 | 5 | 2 | 2 | | L:L:Y1 | R:R:V281 | 3.79 | 2 | Yes | No | 0 | 6 | 2 | 2 | | L:L:?2 | L:L:G3 | 6.96 | 2 | Yes | No | 0 | 0 | 1 | 2 | | L:L:?2 | L:L:?5 | 12.26 | 2 | Yes | No | 0 | 0 | 1 | 0 | | L:L:?2 | R:R:I277 | 7.26 | 2 | Yes | No | 0 | 5 | 1 | 2 | | L:L:?2 | R:R:I304 | 8.71 | 2 | Yes | Yes | 0 | 5 | 1 | 2 | | L:L:G3 | R:R:I304 | 3.53 | 2 | No | Yes | 0 | 5 | 2 | 2 | | L:L:?5 | R:R:K214 | 12.28 | 0 | No | Yes | 0 | 5 | 0 | 1 | | L:L:?5 | R:R:W284 | 18.84 | 0 | No | Yes | 0 | 4 | 0 | 1 | | R:R:D210 | R:R:K214 | 8.3 | 0 | No | Yes | 4 | 5 | 2 | 1 | | R:R:K214 | R:R:V281 | 10.62 | 0 | Yes | No | 5 | 6 | 1 | 2 | | R:R:K214 | R:R:T285 | 4.5 | 0 | Yes | No | 5 | 4 | 1 | 2 | | R:R:F280 | R:R:W284 | 4.01 | 0 | Yes | Yes | 5 | 4 | 2 | 1 | | R:R:I289 | R:R:W284 | 5.87 | 0 | No | Yes | 1 | 4 | 2 | 1 | | R:R:R291 | R:R:W284 | 26.99 | 0 | No | Yes | 1 | 4 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 14.46 | | Average Nodes In Shell | 14.00 | | Average Hubs In Shell | 6.00 | | Average Links In Shell | 16.00 | | Average Links Mediated by Hubs In Shell | 16.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
