CodeHVG
Name4-[(S)-amino(carboxy)methyl]benzene-1,2-dicarboxylic acid
Synonyms(S)-3,4-Dicarboxyphenylglycine (DCPG)
Identifier
FormulaC10 H9 N O6
Molecular Weight239.182
SMILES
PubChem16062593
Formal Charge0
Total Atoms26
Total Chiral Atoms1
Total Bonds26
Total Aromatic Bonds6
Networks2
 missing image

This ligand is also present in the following 2 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9MBC C Aminoacid Metabotropic glutamate mGlu8; mGlu8 Homo Sapiens DCPG AZ12216052 - 2.97 2025-10-01 doi.org/10.1016/j.molcel.2025.08.019

A 2D representation of the interactions of HVG in 9MBC
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:K71 7.88 1 Yes Yes 0 5 0 1
L:L:?1 R:R:R75 7.64 1 Yes Yes 0 4 0 1
L:L:?1 R:R:S156 6.29 1 Yes No 0 9 0 1
L:L:?1 R:R:T179 8.24 1 Yes Yes 0 7 0 1
L:L:?1 R:R:Y227 15.56 1 Yes Yes 0 7 0 1
L:L:?1 R:R:D309 2.84 1 Yes Yes 0 8 0 1
L:L:?1 R:R:K314 3.94 1 Yes No 0 5 0 1
R:R:K68 R:R:K71 8.62 0 No Yes 5 5 2 1
R:R:K71 R:R:R75 3.71 1 Yes Yes 5 4 1 1
R:R:E284 R:R:K71 4.05 0 No Yes 3 5 2 1
R:R:R75 R:R:Y176 6.17 1 Yes Yes 4 7 1 2
R:R:E399 R:R:R75 13.96 1 Yes Yes 5 4 2 1
R:R:K401 R:R:R75 8.66 1 No Yes 4 4 2 1
R:R:A180 R:R:S156 3.42 0 No No 7 9 2 1
R:R:T179 R:R:V196 3.17 1 Yes Yes 7 7 1 2
R:R:D199 R:R:T179 10.12 0 Yes Yes 8 7 2 1
R:R:D309 R:R:T179 2.89 1 Yes Yes 8 7 1 1
R:R:D199 R:R:Q202 5.22 0 Yes Yes 8 9 2 2
R:R:D199 R:R:Y227 4.6 0 Yes Yes 8 7 2 1
R:R:F281 R:R:Q202 3.51 1 Yes Yes 7 9 2 2
R:R:Q202 R:R:S308 4.33 1 Yes Yes 9 8 2 2
R:R:D309 R:R:Q202 6.53 1 Yes Yes 8 9 1 2
R:R:G228 R:R:Y227 4.35 1 No Yes 8 7 2 1
R:R:F281 R:R:Y227 6.19 1 Yes Yes 7 7 2 1
R:R:S308 R:R:Y227 6.36 1 Yes Yes 8 7 2 1
R:R:D309 R:R:Y227 8.05 1 Yes Yes 8 7 1 1
R:R:S310 R:R:Y227 8.9 1 No Yes 6 7 2 1
R:R:F281 R:R:G228 3.01 1 Yes No 7 8 2 2
R:R:F281 R:R:S308 10.57 1 Yes Yes 7 8 2 2
R:R:E284 R:R:K314 9.45 0 No No 3 5 2 1
R:R:D309 R:R:S308 2.94 1 Yes Yes 8 8 1 2
R:R:S308 R:R:S310 3.26 1 Yes No 8 6 2 2
R:R:D309 R:R:S310 2.94 1 Yes No 8 6 1 2
R:R:K314 R:R:P317 3.35 0 No No 5 3 1 2
R:R:E399 R:R:K401 4.05 1 Yes No 5 4 2 2
R:R:G72 R:R:K71 1.74 0 No Yes 5 5 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.48
Average Nodes In Shell23.00
Average Hubs In Shell13.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell33.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of HVG in 9MBC
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
M:M:?1 S:S:K71 7.88 2 Yes Yes 0 5 0 1
M:M:?1 S:S:R75 7.64 2 Yes Yes 0 4 0 1
M:M:?1 S:S:S156 6.29 2 Yes No 0 9 0 1
M:M:?1 S:S:T179 7.21 2 Yes Yes 0 7 0 1
M:M:?1 S:S:Y227 15.56 2 Yes Yes 0 7 0 1
M:M:?1 S:S:D309 2.84 2 Yes Yes 0 8 0 1
M:M:?1 S:S:S310 4.2 2 Yes Yes 0 6 0 1
M:M:?1 S:S:K314 3.94 2 Yes No 0 5 0 1
S:S:K68 S:S:K71 8.62 0 No Yes 5 5 2 1
S:S:K71 S:S:R75 3.71 2 Yes Yes 5 4 1 1
S:S:E284 S:S:K71 4.05 0 No Yes 3 5 2 1
S:S:R75 S:S:Y176 6.17 2 Yes Yes 4 7 1 2
S:S:E399 S:S:R75 13.96 2 Yes Yes 5 4 2 1
S:S:K401 S:S:R75 8.66 2 No Yes 4 4 2 1
S:S:A180 S:S:S156 3.42 0 No No 7 9 2 1
S:S:T179 S:S:V196 3.17 2 Yes Yes 7 7 1 2
S:S:D199 S:S:T179 10.12 0 Yes Yes 8 7 2 1
S:S:D309 S:S:T179 2.89 2 Yes Yes 8 7 1 1
S:S:D199 S:S:Q202 5.22 0 Yes Yes 8 9 2 2
S:S:D199 S:S:Y227 4.6 0 Yes Yes 8 7 2 1
S:S:F281 S:S:Q202 3.51 2 Yes Yes 7 9 2 2
S:S:Q202 S:S:S308 4.33 2 Yes Yes 9 8 2 2
S:S:D309 S:S:Q202 6.53 2 Yes Yes 8 9 1 2
S:S:G228 S:S:Y227 4.35 2 No Yes 8 7 2 1
S:S:F281 S:S:Y227 6.19 2 Yes Yes 7 7 2 1
S:S:S308 S:S:Y227 6.36 2 Yes Yes 8 7 2 1
S:S:D309 S:S:Y227 8.05 2 Yes Yes 8 7 1 1
S:S:S310 S:S:Y227 8.9 2 Yes Yes 6 7 1 1
S:S:F281 S:S:G228 3.01 2 Yes No 7 8 2 2
S:S:F281 S:S:S308 10.57 2 Yes Yes 7 8 2 2
S:S:E284 S:S:K314 9.45 0 No No 3 5 2 1
S:S:D309 S:S:S308 2.94 2 Yes Yes 8 8 1 2
S:S:S308 S:S:S310 3.26 2 Yes Yes 8 6 2 1
S:S:D309 S:S:S310 2.94 2 Yes Yes 8 6 1 1
S:S:K314 S:S:P317 3.35 0 No No 5 3 1 2
S:S:E399 S:S:K401 4.05 2 Yes No 5 4 2 2
S:S:G72 S:S:K71 1.74 0 No Yes 5 5 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub6.00
Average Interaction Strength6.95
Average Nodes In Shell23.00
Average Hubs In Shell14.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell34.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub5.75
Average Interaction Strength7.03
Average Nodes In Shell25.75
Average Hubs In Shell15.00
Average Links In Shell42.50
Average Links Mediated by Hubs In Shell39.00

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)