CodePUC
Name(5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid
Synonyms15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Identifier
FormulaC21 H34 O4
Molecular Weight350.492
SMILES
PubChem5311493
Formal Charge0
Total Atoms59
Total Chiral Atoms5
Total Bonds60
Total Aromatic Bonds0
Networks4
 missing image

This ligand is also present in the following 4 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XJO A Lipid Prostanoid TXA2 Homo Sapiens U46619 - chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 3.11 2024-02-28 doi.org/10.1016/j.celrep.2024.113893

A 2D representation of the interactions of PUC in 8XJO
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:H89 R:R:P28 4.58 1 No No 7 6 1 2
R:R:F30 R:R:F34 4.29 0 No No 5 8 2 2
R:R:F30 R:R:R295 23.52 0 No No 5 8 2 1
L:L:?1 R:R:A31 6.67 1 Yes No 0 7 0 1
R:R:F34 R:R:T298 5.19 0 No No 8 8 2 1
L:L:?1 R:R:C35 5.6 1 Yes No 0 6 0 1
R:R:D74 R:R:P119 6.44 1 Yes No 9 8 2 2
R:R:D74 R:R:Q301 9.14 1 Yes Yes 9 9 2 1
R:R:L78 R:R:Q301 3.99 1 No Yes 8 9 1 1
L:L:?1 R:R:L78 5.86 1 Yes No 0 8 0 1
L:L:?1 R:R:T81 10.4 1 Yes No 0 7 0 1
L:L:?1 R:R:V85 9.46 1 Yes No 0 8 0 1
R:R:H89 R:R:S181 8.37 1 No No 7 8 1 1
L:L:?1 R:R:H89 9.07 1 Yes No 0 7 0 1
R:R:M108 R:R:M112 5.78 0 No No 6 8 2 1
R:R:F184 R:R:M112 4.98 0 Yes No 8 8 2 1
L:L:?1 R:R:M112 5.99 1 Yes No 0 8 0 1
L:L:?1 R:R:G116 6.03 1 Yes No 0 7 0 1
R:R:P119 R:R:Q301 7.9 1 No Yes 8 9 2 1
R:R:L120 R:R:W258 13.67 0 No Yes 8 8 2 1
R:R:Q177 R:R:W182 9.86 0 No Yes 7 7 2 1
R:R:P179 R:R:S181 3.56 0 No No 8 8 2 1
L:L:?1 R:R:S181 5.3 1 Yes No 0 8 0 1
R:R:F184 R:R:W182 7.02 0 Yes Yes 8 7 2 1
R:R:L291 R:R:W182 3.42 0 No Yes 7 7 2 1
R:R:L294 R:R:W182 6.83 1 No Yes 7 7 1 1
L:L:?1 R:R:W182 12.86 1 Yes Yes 0 7 0 1
R:R:A297 R:R:W258 7.78 0 No Yes 8 8 2 1
R:R:N300 R:R:W258 12.43 1 Yes Yes 9 8 2 1
R:R:Q301 R:R:W258 6.57 1 Yes Yes 9 8 1 1
L:L:?1 R:R:W258 4.82 1 Yes Yes 0 8 0 1
R:R:L291 R:R:R295 12.15 0 No No 7 8 2 1
L:L:?1 R:R:L294 7.81 1 Yes No 0 7 0 1
L:L:?1 R:R:R295 4.29 1 Yes No 0 8 0 1
L:L:?1 R:R:T298 10.4 1 Yes No 0 8 0 1
R:R:N300 R:R:Q301 6.6 1 Yes Yes 9 9 2 1
L:L:?1 R:R:Q301 4.7 1 Yes Yes 0 9 0 1
R:R:T81 R:R:V111 3.17 0 No No 7 5 1 2
L:L:?1 R:R:G82 2.41 1 Yes No 0 8 0 1
StatisticsValue
Average Number Of Links16.00
Average Number Of Links With An Hub3.00
Average Interaction Strength6.98
Average Nodes In Shell31.00
Average Hubs In Shell7.00
Average Links In Shell39.00
Average Links Mediated by Hubs In Shell30.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9GG5 A Lipid Prostanoid TXA2 Homo Sapiens U46619 - chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 3.26 2025-08-27 To be published

A 2D representation of the interactions of PUC in 9GG5
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:A31 4.45 2 Yes Yes 0 7 0 1
L:L:?1 R:R:L78 3.91 2 Yes Yes 0 8 0 1
L:L:?1 R:R:T81 10.4 2 Yes No 0 7 0 1
L:L:?1 R:R:G82 2.41 2 Yes Yes 0 8 0 1
L:L:?1 R:R:V85 9.46 2 Yes Yes 0 8 0 1
L:L:?1 R:R:H89 7.26 2 Yes Yes 0 7 0 1
L:L:?1 R:R:M112 4.99 2 Yes No 0 8 0 1
L:L:?1 R:R:G116 2.41 2 Yes No 0 7 0 1
L:L:?1 R:R:P179 2.32 2 Yes Yes 0 8 0 1
L:L:?1 R:R:S181 3.18 2 Yes Yes 0 8 0 1
L:L:?1 R:R:W182 8.04 2 Yes Yes 0 7 0 1
L:L:?1 R:R:F184 1.72 2 Yes Yes 0 8 0 1
L:L:?1 R:R:W258 4.02 2 Yes Yes 0 8 0 1
L:L:?1 R:R:L291 1.95 2 Yes Yes 0 7 0 1
L:L:?1 R:R:R295 1.71 2 Yes Yes 0 8 0 1
L:L:?1 R:R:T298 17.68 2 Yes No 0 8 0 1
L:L:?1 R:R:Q301 8.45 2 Yes Yes 0 9 0 1
R:R:I17 R:R:R22 3.76 2 No Yes 3 1 2 2
R:R:I17 R:R:Y178 6.04 2 No Yes 3 3 2 2
R:R:I17 R:R:P179 3.39 2 No Yes 3 8 2 1
R:R:A26 R:R:R22 4.15 0 No Yes 4 1 2 2
R:R:P28 R:R:R22 2.88 2 No Yes 6 1 2 2
R:R:H89 R:R:R22 3.39 2 Yes Yes 7 1 1 2
R:R:I25 R:R:L291 2.85 0 No Yes 3 7 2 1
R:R:A26 R:R:P179 3.74 0 No Yes 4 8 2 1
R:R:H89 R:R:P28 9.15 2 Yes No 7 6 1 2
R:R:F30 R:R:F34 6.43 2 No Yes 5 8 2 2
R:R:F30 R:R:R295 12.83 2 No Yes 5 8 2 1
R:R:A31 R:R:V85 3.39 2 Yes Yes 7 8 1 1
R:R:A31 R:R:H89 2.93 2 Yes Yes 7 7 1 1
R:R:F34 R:R:R295 3.21 2 Yes Yes 8 8 2 1
R:R:C35 R:R:L39 3.17 0 No Yes 6 6 2 2
R:R:C35 R:R:G82 3.92 0 No Yes 6 8 2 1
R:R:G38 R:R:L78 1.71 0 No Yes 9 8 2 1
R:R:L39 R:R:L78 2.77 19 Yes Yes 6 8 2 1
R:R:D74 R:R:N42 5.39 2 Yes Yes 9 9 2 2
R:R:L78 R:R:N42 2.75 0 Yes Yes 8 9 1 2
R:R:D74 R:R:P119 3.22 2 Yes Yes 9 8 2 2
R:R:D74 R:R:Q301 7.83 2 Yes Yes 9 9 2 1
R:R:G82 R:R:T81 1.82 2 Yes No 8 7 1 1
R:R:G82 R:R:V85 1.84 2 Yes Yes 8 8 1 1
R:R:H89 R:R:V85 2.77 2 Yes Yes 7 8 1 1
R:R:S181 R:R:V85 4.85 2 Yes Yes 8 8 1 1
R:R:Q88 R:R:S181 4.33 0 No Yes 6 8 2 1
R:R:H89 R:R:S181 5.58 2 Yes Yes 7 8 1 1
R:R:G109 R:R:M112 1.75 0 No No 8 8 2 1
R:R:F184 R:R:M112 6.22 2 Yes No 8 8 1 1
R:R:F184 R:R:I113 3.77 2 Yes Yes 8 7 1 2
R:R:G116 R:R:P119 2.03 2 No Yes 7 8 1 2
R:R:G116 R:R:W258 2.81 2 No Yes 7 8 1 1
R:R:P119 R:R:Q301 6.32 2 Yes Yes 8 9 2 1
R:R:L120 R:R:W258 13.67 2 No Yes 8 8 2 1
R:R:Q177 R:R:W182 9.86 2 Yes Yes 7 7 2 1
R:R:F184 R:R:Q177 3.51 2 Yes Yes 8 7 1 2
R:R:L290 R:R:Q177 3.99 2 Yes Yes 6 7 2 2
R:R:P179 R:R:Y178 12.52 2 Yes Yes 8 3 1 2
R:R:L291 R:R:Y178 2.34 2 Yes Yes 7 3 1 2
R:R:P179 R:R:S181 3.56 2 Yes Yes 8 8 1 1
R:R:P179 R:R:W182 2.7 2 Yes Yes 8 7 1 1
R:R:F184 R:R:W182 6.01 2 Yes Yes 8 7 1 1
R:R:L290 R:R:W182 5.69 2 Yes Yes 6 7 2 1
R:R:L294 R:R:W182 9.11 2 No Yes 7 7 2 1
R:R:F184 R:R:L185 9.74 2 Yes No 8 5 1 2
R:R:L261 R:R:W258 4.56 2 Yes Yes 7 8 2 1
R:R:L262 R:R:W258 3.42 2 No Yes 8 8 2 1
R:R:A297 R:R:W258 5.19 2 No Yes 8 8 2 1
R:R:N300 R:R:W258 9.04 2 No Yes 9 8 2 1
R:R:Q301 R:R:W258 4.38 2 Yes Yes 9 8 1 1
R:R:L261 R:R:L294 5.54 2 Yes No 7 7 2 2
R:R:A297 R:R:L261 3.15 2 No Yes 8 7 2 2
R:R:L290 R:R:L294 2.77 2 Yes No 6 7 2 2
R:R:L291 R:R:R295 17.01 2 Yes Yes 7 8 1 1
R:R:N300 R:R:Q301 7.92 2 No Yes 9 9 2 1
R:R:A31 R:R:V86 1.7 2 Yes No 7 7 1 2
StatisticsValue
Average Number Of Links17.00
Average Number Of Links With An Hub13.00
Average Interaction Strength5.55
Average Nodes In Shell45.00
Average Hubs In Shell25.00
Average Links In Shell74.00
Average Links Mediated by Hubs In Shell73.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links14.75
Average Number Of Links With An Hub5.50
Average Interaction Strength6.84
Average Nodes In Shell33.25
Average Hubs In Shell11.50
Average Links In Shell45.50
Average Links Mediated by Hubs In Shell39.75

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)