psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P42	R:R:Y116	8.34	No	Yes	7	4	4
2	R:R:P42	R:R:Y199	16.69	No	Yes	7	4	3
3	R:R:E112	R:R:Y46	10.1	No	Yes	0	6	6
4	R:R:L113	R:R:Y46	8.21	No	Yes	0	7	6
5	R:R:L109	R:R:V58	10.43	No	No	0	8	7
6	R:R:V58	R:R:W424	4.9	No	Yes	0	7	8
7	R:R:L61	R:R:M105	7.07	No	Yes	0	7	8
8	R:R:I62	R:R:M105	4.37	No	Yes	0	8	8
9	R:R:I62	R:R:P106	5.08	No	No	0	8	9
10	R:R:F64	R:R:S431	5.28	No	No	0	5	8
11	R:R:S431	R:R:T65	4.8	No	No	0	8	8
12	R:R:G68	R:R:P434	4.06	No	No	0	9	9
13	R:R:A94	R:R:N69	4.69	No	No	0	9	9
14	R:R:D97	R:R:N69	12.12	No	No	0	9	9
15	R:R:N69	R:R:P434	11.4	No	No	0	9	9
16	R:R:I451	R:R:L71	4.28	No	No	0	8	8
17	R:R:L452	R:R:L71	4.15	No	No	0	8	8
18	R:R:V72	R:R:Y437	5.05	No	Yes	0	9	9
19	R:R:I451	R:R:I74	4.42	No	No	0	8	6
20	R:R:V76	R:R:V91	4.81	No	No	0	9	8
21	R:R:L82	R:R:S79	9.01	No	No	0	9	7
22	R:R:S447	R:R:S79	4.89	No	No	0	8	7
23	R:R:A81	R:R:D443	6.18	No	Yes	0	7	8
24	R:R:D443	R:R:L82	4.07	Yes	No	0	8	9
25	R:R:F444	R:R:L82	12.18	Yes	No	0	9	9
26	R:R:A84	R:R:Q86	4.55	No	No	0	8	8
27	R:R:P165	R:R:P85	7.79	No	No	0	6	7
28	R:R:D148	R:R:Q86	5.22	Yes	No	3	9	8
29	R:R:Q86	R:R:R163	24.53	No	Yes	3	8	8
30	R:R:L90	R:R:N87	5.49	No	No	0	8	9
31	R:R:L88	R:R:V168	4.47	No	No	0	7	8
32	R:R:F89	R:R:I145	5.02	Yes	No	0	8	9
33	R:R:D148	R:R:F89	4.78	Yes	Yes	0	9	8
34	R:R:F89	R:R:V168	6.55	Yes	No	0	8	8
35	R:R:F89	R:R:T171	5.19	Yes	No	0	8	7
36	R:R:L90	R:R:Y437	7.03	No	Yes	0	8	9
37	R:R:H141	R:R:S92	8.37	Yes	No	8	8	9
38	R:R:I172	R:R:S92	7.74	No	No	0	9	9
39	R:R:S92	R:R:W176	6.18	No	Yes	8	9	9
40	R:R:H141	R:R:L93	6.43	Yes	No	0	8	9
41	R:R:D97	R:R:S430	8.83	No	No	0	9	9
42	R:R:F134	R:R:L99	8.53	No	No	0	7	8
43	R:R:L103	R:R:T102	4.42	No	No	0	6	6
44	R:R:V104	R:R:Y127	6.31	No	Yes	0	9	5
45	R:R:D131	R:R:V104	5.84	No	No	0	9	9
46	R:R:M105	R:R:W424	5.82	Yes	Yes	1	8	8
47	R:R:M105	R:R:Y427	8.38	Yes	Yes	1	8	8
48	R:R:F107	R:R:W117	4.01	Yes	Yes	1	7	9
49	R:R:F107	R:R:F119	10.72	Yes	Yes	1	7	7
50	R:R:F107	R:R:W123	20.04	Yes	Yes	1	7	5
51	R:R:F107	R:R:Y127	6.19	Yes	Yes	1	7	5
52	R:R:S108	R:R:Y127	5.09	No	Yes	0	8	5
53	R:R:S108	R:R:Y427	7.63	No	Yes	0	8	8
54	R:R:L109	R:R:L113	8.3	No	No	0	8	7
55	R:R:N111	R:R:W117	7.91	No	Yes	0	6	9
56	R:R:E112	R:R:K420	13.5	No	No	0	6	5
57	R:R:Y116	R:R:Y118	5.96	Yes	No	0	4	5
58	R:R:Y116	R:R:Y199	17.87	Yes	Yes	7	4	3
59	R:R:F119	R:R:W117	17.04	Yes	Yes	1	7	9
60	R:R:W117	R:R:W123	4.69	Yes	Yes	1	9	5
61	R:R:C124	R:R:W117	5.22	No	Yes	1	9	9
62	R:R:W117	R:R:Y127	11.58	Yes	Yes	1	9	5
63	R:R:C202	R:R:W117	16.98	No	Yes	1	9	9
64	R:R:F119	R:R:Y118	4.13	Yes	No	0	7	5
65	R:R:F119	R:R:W123	4.01	Yes	Yes	1	7	5
66	R:R:W122	R:R:W123	7.5	No	Yes	1	5	5
67	R:R:V126	R:R:W122	6.13	No	No	1	6	5
68	R:R:V126	R:R:W123	7.36	No	Yes	1	6	5
69	R:R:C124	R:R:C202	7.28	No	No	1	9	9
70	R:R:L128	R:R:Y127	4.69	Yes	Yes	0	7	5
71	L:L:?1	R:R:Y127	4.05	Yes	Yes	1	0	5
72	R:R:C202	R:R:L128	4.76	No	Yes	0	9	7
73	R:R:L128	R:R:L204	4.15	Yes	Yes	0	7	7
74	R:R:F134	R:R:L130	12.18	No	No	0	7	6
75	R:R:D131	R:R:Y427	5.75	No	Yes	1	9	8
76	L:L:?1	R:R:D131	29.1	Yes	No	1	0	9
77	R:R:S183	R:R:V132	4.85	No	No	0	8	8
78	L:L:?1	R:R:V132	11.34	Yes	No	0	0	8
79	R:R:F134	R:R:W176	4.01	No	Yes	0	7	9
80	R:R:C135	R:R:W395	9.14	No	Yes	0	8	8
81	L:L:?1	R:R:C135	6.59	Yes	No	0	0	8
82	R:R:S183	R:R:T136	6.4	No	No	0	8	8
83	R:R:S218	R:R:T136	9.59	No	No	0	8	8
84	R:R:S137	R:R:W176	11.12	No	Yes	0	8	9
85	R:R:S137	R:R:S179	6.52	No	No	0	8	8
86	R:R:S138	R:R:W391	6.18	No	Yes	0	9	9
87	R:R:V140	R:R:V175	4.81	No	No	0	8	8
88	R:R:I178	R:R:V140	4.61	No	No	0	6	8
89	R:R:S179	R:R:V140	4.85	No	No	0	8	8
90	R:R:H141	R:R:V175	6.92	Yes	No	0	8	8
91	R:R:H141	R:R:W176	5.29	Yes	Yes	8	8	9
92	R:R:L142	R:R:M226	7.07	No	No	0	9	9
93	R:R:L142	R:R:M388	9.9	No	No	0	9	8
94	R:R:L142	R:R:W391	7.97	No	Yes	0	9	9
95	R:R:C143	R:R:I225	4.91	No	No	0	8	7
96	R:R:I145	R:R:L384	5.71	No	No	0	9	8
97	R:R:S146	R:R:V229	8.08	No	No	0	9	8
98	R:R:L147	R:R:W151	9.11	No	No	0	8	5
99	R:R:D148	R:R:Y159	9.2	Yes	No	3	9	9
100	R:R:D148	R:R:R163	13.1	Yes	Yes	3	9	8
101	R:R:R149	R:R:R163	4.26	Yes	Yes	3	9	8
102	R:R:E377	R:R:R149	5.82	No	Yes	0	8	9
103	R:R:F380	R:R:R149	6.41	Yes	Yes	3	8	9
104	R:R:R149	R:R:T381	12.94	Yes	No	0	9	8
105	R:R:L384	R:R:R149	6.07	No	Yes	3	8	9
106	R:R:W151	R:R:Y150	4.82	No	Yes	0	5	9
107	R:R:T154	R:R:Y150	8.74	No	Yes	0	8	9
108	R:R:R232	R:R:Y150	12.35	No	Yes	0	7	9
109	R:R:I233	R:R:Y150	4.84	No	Yes	0	9	9
110	R:R:W151	R:R:Y159	12.54	No	No	0	5	9
111	R:R:R163	R:R:S152	7.91	Yes	No	0	8	8
112	R:R:R163	R:R:Y159	10.29	Yes	No	3	8	9
113	R:R:N160	R:R:R163	6.03	No	Yes	0	7	8
114	R:R:K162	R:R:R167	11.14	No	No	0	5	7
115	R:R:R167	R:R:T164	5.17	No	No	0	7	8
116	R:R:F184	R:R:P186	18.78	No	No	0	6	8
117	R:R:P185	R:R:P186	5.84	No	No	0	9	8
118	R:R:L204	R:R:Y210	5.86	Yes	Yes	0	7	7
119	L:L:?1	R:R:L204	6.7	Yes	Yes	0	0	7
120	R:R:E207	R:R:N205	10.52	No	No	0	6	7
121	R:R:N205	R:R:Y210	11.63	No	Yes	0	7	7
122	R:R:D206	R:R:Y405	6.9	No	No	0	5	4
123	R:R:E207	R:R:W209	8.72	No	No	0	6	5
124	R:R:R409	R:R:T208	6.47	No	No	0	5	5
125	R:R:W209	R:R:Y210	5.79	No	Yes	0	5	7
126	R:R:S214	R:R:Y210	12.72	No	Yes	0	8	7
127	R:R:Y210	R:R:Y402	3.97	Yes	Yes	0	7	8
128	R:R:I211	R:R:Y402	14.51	No	Yes	0	7	8
129	R:R:G406	R:R:I211	5.29	No	No	0	7	7
130	R:R:I407	R:R:L212	4.28	No	No	0	5	7
131	L:L:?1	R:R:S214	4.15	Yes	No	0	0	8
132	R:R:C215	R:R:F399	4.19	No	Yes	0	8	8
133	R:R:C215	R:R:Y402	5.38	No	Yes	0	8	8
134	L:L:?1	R:R:S218	4.15	Yes	No	0	0	8
135	R:R:F219	R:R:F220	10.72	Yes	No	0	8	7
136	R:R:C223	R:R:F219	8.38	No	Yes	0	7	8
137	R:R:F219	R:R:W391	4.01	Yes	Yes	0	8	9
138	R:R:F219	R:R:F396	5.36	Yes	No	0	8	7
139	R:R:F219	R:R:F399	22.51	Yes	Yes	0	8	8
140	R:R:F220	R:R:S403	6.61	No	No	0	7	7
141	R:R:C223	R:R:V392	5.12	No	No	0	7	8
142	R:R:I233	R:R:Y230	10.88	No	Yes	0	9	9
143	R:R:Y230	R:R:Y234	5.96	Yes	No	0	9	6
144	R:R:A385	R:R:Y230	5.34	No	Yes	0	8	9
145	R:R:M388	R:R:Y230	8.38	No	Yes	0	8	9
146	R:R:L239	R:R:R240	8.5	No	No	0	5	8
147	R:R:D443	R:R:R376	8.34	Yes	No	0	8	7
148	R:R:F380	R:R:L384	7.31	Yes	No	3	8	8
149	R:R:F380	R:R:N441	6.04	Yes	No	3	8	9
150	R:R:F380	R:R:F444	4.29	Yes	Yes	3	8	9
151	R:R:F382	R:R:V386	6.55	No	No	9	7	8
152	R:R:F382	R:R:F440	4.29	No	Yes	9	7	8
153	R:R:F440	R:R:V383	3.93	Yes	No	0	8	9
154	R:R:I436	R:R:V386	4.61	No	No	0	9	8
155	R:R:F440	R:R:V386	3.93	Yes	No	9	8	8
156	R:R:N433	R:R:V387	8.87	No	No	3	9	9
157	R:R:I436	R:R:V387	4.61	No	No	0	9	9
158	R:R:V387	R:R:Y437	5.05	No	Yes	3	9	9
159	R:R:I436	R:R:V390	4.61	No	No	0	9	7
160	R:R:W391	R:R:W395	10.31	Yes	Yes	0	9	8
161	R:R:N429	R:R:W391	11.3	No	Yes	0	9	9
162	R:R:C394	R:R:N429	9.45	No	No	0	9	9
163	R:R:F399	R:R:W395	6.01	Yes	Yes	0	8	8
164	R:R:G426	R:R:W395	11.26	No	Yes	0	8	8
165	R:R:F396	R:R:F400	11.79	No	No	0	7	7
166	R:R:F422	R:R:P397	10.11	Yes	No	0	6	9
167	R:R:F398	R:R:F399	12.86	Yes	Yes	1	8	8
168	R:R:F398	R:R:Y402	12.38	Yes	Yes	1	8	8
169	R:R:F398	R:R:F419	8.57	Yes	No	1	8	5
170	R:R:F398	R:R:F423	7.5	Yes	Yes	1	8	6
171	L:L:?1	R:R:F398	12.64	Yes	Yes	1	0	8
172	L:L:?1	R:R:F399	7.58	Yes	Yes	1	0	8
173	R:R:F400	R:R:L404	6.09	No	No	0	7	6
174	R:R:S401	R:R:V414	9.7	No	No	0	6	6
175	R:R:F422	R:R:S401	3.96	Yes	No	0	6	6
176	R:R:F419	R:R:Y402	4.13	No	Yes	1	5	8
177	L:L:?1	R:R:Y402	8.11	Yes	Yes	1	0	8
178	R:R:C412	R:R:L404	4.76	No	No	0	7	6
179	R:R:R409	R:R:Y405	11.32	No	No	0	5	4
180	R:R:Q413	R:R:Y405	9.02	No	No	0	2	4
181	R:R:C408	R:R:C412	7.28	No	No	0	7	7
182	R:R:E410	R:R:Q413	11.47	No	No	0	4	2
183	R:R:F419	R:R:V414	3.93	No	No	0	5	6
184	R:R:P415	S:S:P417	7.79	No	No	0	7	3
185	R:R:G416	R:R:P417	4.06	No	No	0	2	3
186	R:R:P417	S:S:P415	7.79	No	No	0	3	7
187	R:R:P417	S:S:P417	11.69	No	No	0	3	3
188	R:R:F422	R:R:L418	6.09	Yes	No	2	6	5
189	R:R:L418	S:S:F421	8.53	No	Yes	2	5	6
190	R:R:F423	R:R:K420	4.96	Yes	No	0	6	5
191	R:R:F421	R:R:I425	7.54	Yes	No	0	6	8
192	R:R:F421	S:S:L418	9.74	Yes	No	2	6	5
193	R:R:F421	S:S:F421	4.29	Yes	Yes	2	6	6
194	R:R:F421	S:S:F422	8.57	Yes	Yes	2	6	6
195	R:R:F422	S:S:F421	6.43	Yes	Yes	2	6	6
196	R:R:F423	R:R:W424	5.01	Yes	Yes	1	6	8
197	L:L:?1	R:R:F423	16.85	Yes	Yes	1	0	6
198	R:R:W424	R:R:Y427	13.5	Yes	Yes	1	8	8
199	L:L:?1	R:R:Y427	5.68	Yes	Yes	1	0	8
200	R:R:N433	R:R:Y437	5.81	No	Yes	3	9	9
201	R:R:F444	R:R:Y437	18.57	Yes	Yes	3	9	9
202	R:R:F448	R:R:T438	9.08	No	No	0	8	9
203	R:R:F440	R:R:V439	7.87	Yes	No	0	8	7
204	R:R:D443	R:R:N441	6.73	Yes	No	0	8	9
205	R:R:F444	R:R:N441	8.46	Yes	No	3	9	9
206	R:R:D443	R:R:Q442	9.14	Yes	No	0	8	5
207	R:R:Q442	R:R:R446	5.84	No	No	0	5	5
208	R:R:F444	R:R:F448	7.5	Yes	No	0	9	8
209	R:R:H450	R:R:R454	6.77	No	No	0	6	5
210	R:R:F453	R:R:L452	7.31	No	No	0	4	8
211	S:S:P41	S:S:P42	5.84	No	No	0	3	4
212	S:S:G44	S:S:R43	6	No	No	0	5	1
213	S:S:Q45	S:S:Y46	10.15	No	Yes	0	2	6
214	S:S:E112	S:S:Y46	10.1	No	Yes	0	6	6
215	S:S:L113	S:S:Y46	5.86	Yes	Yes	0	7	6
216	S:S:L113	S:S:V51	7.45	Yes	No	0	7	5
217	S:S:L109	S:S:V58	10.43	No	No	0	8	7
218	S:S:V58	S:S:W424	8.58	No	Yes	0	7	8
219	S:S:F60	S:S:F64	5.36	No	No	0	4	5
220	S:S:I62	S:S:M105	4.37	No	No	0	8	8
221	S:S:I62	S:S:P106	5.08	No	No	0	8	9
222	S:S:F64	S:S:S431	3.96	No	Yes	0	5	8
223	S:S:S431	S:S:T65	4.8	Yes	No	0	8	8
224	S:S:G68	S:S:P434	4.06	No	No	0	9	9
225	S:S:A94	S:S:N69	4.69	No	No	0	9	9
226	S:S:D97	S:S:N69	6.73	No	No	0	9	9
227	S:S:N69	S:S:P434	11.4	No	No	0	9	9
228	S:S:I451	S:S:L71	5.71	No	No	0	8	8
229	S:S:L452	S:S:L71	9.69	No	No	0	8	8
230	S:S:V72	S:S:Y437	5.05	No	Yes	0	9	9
231	S:S:V73	S:S:V91	4.81	No	No	0	7	8
232	S:S:I451	S:S:I74	5.89	No	No	0	8	6
233	S:S:N87	S:S:V76	4.43	Yes	No	0	9	9
234	S:S:V76	S:S:V91	4.81	No	No	0	9	8
235	S:S:L82	S:S:S79	6.01	No	No	0	9	7
236	S:S:R446	S:S:S79	7.91	No	No	0	5	7
237	S:S:S447	S:S:S79	6.52	No	No	0	8	7
238	S:S:R80	S:S:R83	5.33	No	No	0	8	8
239	S:S:A81	S:S:R376	5.53	No	No	6	7	7
240	S:S:A81	S:S:D443	6.18	No	Yes	6	7	8
241	S:S:L82	S:S:N87	4.12	No	Yes	0	9	9
242	S:S:F444	S:S:L82	12.18	Yes	No	0	9	9
243	S:S:P85	S:S:R163	7.21	No	Yes	0	7	8
244	S:S:P165	S:S:P85	7.79	No	No	0	6	7
245	S:S:D148	S:S:Q86	6.53	No	Yes	5	9	8
246	S:S:Q86	S:S:R149	11.68	Yes	Yes	5	8	9
247	S:S:Q86	S:S:R163	16.35	Yes	Yes	5	8	8
248	S:S:E377	S:S:Q86	11.47	Yes	Yes	5	8	8
249	S:S:F380	S:S:Q86	5.86	Yes	Yes	5	8	8
250	S:S:L90	S:S:N87	4.12	No	Yes	0	8	9
251	S:S:F380	S:S:N87	9.67	Yes	Yes	0	8	9
252	S:S:L88	S:S:V168	5.96	No	No	0	7	8
253	S:S:K169	S:S:L88	8.46	No	No	0	5	7
254	S:S:F89	S:S:I145	5.02	Yes	No	0	8	9
255	S:S:F89	S:S:V168	6.55	Yes	No	0	8	8
256	S:S:F89	S:S:T171	5.19	Yes	No	0	8	7
257	S:S:L384	S:S:L90	4.15	No	No	0	8	8
258	S:S:L90	S:S:Y437	11.72	No	Yes	0	8	9
259	S:S:H141	S:S:S92	9.76	Yes	No	10	8	9
260	S:S:I172	S:S:S92	9.29	No	No	0	9	9
261	S:S:S92	S:S:W176	6.18	No	Yes	10	9	9
262	S:S:H141	S:S:L93	7.71	Yes	No	0	8	9
263	S:S:D97	S:S:S430	10.31	No	No	0	9	9
264	S:S:L103	S:S:L99	4.15	No	No	0	6	8
265	S:S:F134	S:S:L99	12.18	Yes	No	0	7	8
266	S:S:F134	S:S:V100	3.93	Yes	No	0	7	9
267	S:S:S430	S:S:V100	4.85	No	No	0	9	9
268	S:S:D131	S:S:V104	4.38	No	No	0	9	9
269	S:S:M105	S:S:W424	4.65	No	Yes	2	8	8
270	S:S:M105	S:S:Y427	9.58	No	Yes	2	8	8
271	S:S:F107	S:S:W117	4.01	Yes	Yes	4	7	9
272	S:S:F107	S:S:F119	12.86	Yes	Yes	4	7	7
273	S:S:F107	S:S:W123	19.04	Yes	Yes	4	7	5
274	S:S:F107	S:S:Y127	5.16	Yes	Yes	4	7	5
275	S:S:S108	S:S:Y127	7.63	No	Yes	0	8	5
276	S:S:S108	S:S:Y427	8.9	No	Yes	0	8	8
277	S:S:L109	S:S:L113	8.3	No	Yes	0	8	7
278	S:S:N111	S:S:W117	10.17	No	Yes	0	6	9
279	S:S:E112	S:S:K420	13.5	No	No	0	6	5
280	S:S:M114	S:S:Y116	4.79	No	Yes	4	6	4
281	S:S:M114	S:S:Y118	5.99	No	No	4	6	5
282	S:S:Y116	S:S:Y118	4.96	Yes	No	4	4	5
283	S:S:P200	S:S:Y116	4.17	No	Yes	0	4	4
284	S:S:F119	S:S:W117	16.04	Yes	Yes	4	7	9
285	S:S:W117	S:S:W123	5.62	Yes	Yes	4	9	5
286	S:S:C124	S:S:W117	7.84	No	Yes	4	9	9
287	S:S:W117	S:S:Y127	11.58	Yes	Yes	4	9	5
288	S:S:C202	S:S:W117	14.37	No	Yes	4	9	9
289	S:S:W122	S:S:W123	5.62	No	Yes	4	5	5
290	S:S:V126	S:S:W122	8.58	No	No	4	6	5
291	S:S:V126	S:S:W123	7.36	No	Yes	4	6	5
292	S:S:C124	S:S:C202	7.28	No	No	4	9	9
293	S:S:L128	S:S:Y127	4.69	No	Yes	0	7	5
294	S:S:L128	S:S:L204	5.54	No	No	0	7	7
295	S:S:A129	S:S:F184	4.16	No	Yes	0	8	6
296	S:S:F134	S:S:L130	12.18	Yes	No	0	7	6
297	S:S:D131	S:S:Y427	5.75	No	Yes	0	9	8
298	M:M:?1	S:S:D131	26.28	Yes	No	0	0	9
299	S:S:V132	S:S:Y191	10.09	No	No	0	8	5
300	M:M:?1	S:S:V132	11.34	Yes	No	0	0	8
301	S:S:L133	S:S:S183	7.51	No	No	11	8	8
302	S:S:F184	S:S:L133	4.87	Yes	No	11	6	8
303	S:S:F134	S:S:W176	4.01	Yes	Yes	0	7	9
304	S:S:C135	S:S:W395	10.45	No	Yes	0	8	8
305	M:M:?1	S:S:C135	6.59	Yes	No	0	0	8
306	S:S:I182	S:S:T136	4.56	No	No	0	8	8
307	S:S:S183	S:S:T136	6.4	No	No	0	8	8
308	S:S:S218	S:S:T136	9.59	No	No	0	8	8
309	S:S:S137	S:S:W176	11.12	No	Yes	0	8	9
310	S:S:S138	S:S:W391	6.18	No	Yes	0	9	9
311	S:S:I178	S:S:V140	4.61	No	No	0	6	8
312	S:S:S179	S:S:V140	4.85	No	No	0	8	8
313	S:S:H141	S:S:V175	5.54	Yes	No	0	8	8
314	S:S:H141	S:S:W176	5.29	Yes	Yes	10	8	9
315	S:S:L142	S:S:M226	5.65	No	No	12	9	9
316	S:S:L142	S:S:M388	8.48	No	Yes	12	9	8
317	S:S:L142	S:S:W391	5.69	No	Yes	0	9	9
318	S:S:C143	S:S:I225	8.18	No	No	0	8	7
319	S:S:I145	S:S:L384	9.99	No	No	0	9	8
320	S:S:S146	S:S:V229	8.08	No	No	0	9	8
321	S:S:L147	S:S:W151	4.56	No	No	0	8	5
322	S:S:D148	S:S:S152	4.42	No	No	5	9	8
323	S:S:D148	S:S:R163	4.76	No	Yes	5	9	8
324	S:S:E377	S:S:R149	6.98	Yes	Yes	5	8	9
325	S:S:F380	S:S:R149	8.55	Yes	Yes	5	8	9
326	S:S:R149	S:S:T381	12.94	Yes	No	0	9	8
327	S:S:W151	S:S:Y150	7.72	No	No	0	5	9
328	S:S:T154	S:S:Y150	9.99	No	No	0	8	9
329	S:S:R232	S:S:Y150	14.4	No	No	0	7	9
330	S:S:R163	S:S:S152	5.27	Yes	No	5	8	8
331	S:S:E377	S:S:S152	5.75	Yes	No	5	8	8
332	S:S:V153	S:S:V236	4.81	No	No	0	8	7
333	S:S:E158	S:S:Q155	12.74	No	No	13	6	7
334	S:S:Q155	S:S:Y159	14.65	No	No	13	7	9
335	S:S:E158	S:S:Y159	10.1	No	No	13	6	9
336	S:S:N160	S:S:R163	4.82	No	Yes	0	7	8
337	S:S:K162	S:S:R167	11.14	No	No	0	5	7
338	S:S:E377	S:S:R163	5.82	Yes	Yes	5	8	8
339	S:S:F184	S:S:S183	5.28	Yes	No	11	6	8
340	S:S:F184	S:S:Y191	7.22	Yes	No	0	6	5
341	S:S:P185	S:S:S189	7.13	No	No	0	9	6
342	S:S:D206	S:S:R192	9.53	No	No	0	5	5
343	S:S:L204	S:S:Y210	8.21	No	Yes	0	7	7
344	M:M:?1	S:S:L204	5.74	Yes	No	0	0	7
345	S:S:E207	S:S:N205	6.57	No	No	0	6	7
346	S:S:N205	S:S:Y210	10.47	No	Yes	0	7	7
347	S:S:D206	S:S:Y405	5.75	No	No	0	5	4
348	S:S:S214	S:S:Y210	11.45	No	Yes	0	8	7
349	S:S:Y210	S:S:Y402	3.97	Yes	Yes	0	7	8
350	S:S:I211	S:S:Y402	15.71	No	Yes	0	7	8
351	S:S:G406	S:S:I211	5.29	No	No	0	7	7
352	S:S:I407	S:S:L212	4.28	No	No	0	5	7
353	M:M:?1	S:S:S214	4.15	Yes	No	0	0	8
354	S:S:C215	S:S:F399	4.19	No	Yes	0	8	8
355	S:S:C215	S:S:Y402	5.38	No	Yes	0	8	8
356	S:S:C215	S:S:S403	5.16	No	No	0	8	7
357	M:M:?1	S:S:S218	4.15	Yes	No	0	0	8
358	S:S:F219	S:S:F220	9.65	Yes	No	0	8	7
359	S:S:C223	S:S:F219	8.38	No	Yes	0	7	8
360	S:S:F219	S:S:W391	5.01	Yes	Yes	0	8	9
361	S:S:F219	S:S:F396	4.29	Yes	No	0	8	7
362	S:S:F219	S:S:F399	21.43	Yes	Yes	0	8	8
363	S:S:F220	S:S:S403	6.61	No	No	0	7	7
364	S:S:C223	S:S:V392	5.12	No	No	0	7	8
365	S:S:L224	S:S:L228	8.3	No	No	0	5	5
366	S:S:M226	S:S:M388	5.78	No	Yes	12	9	8
367	S:S:I233	S:S:Y230	10.88	No	Yes	0	9	9
368	S:S:T381	S:S:Y230	4.99	No	Yes	0	8	9
369	S:S:A385	S:S:Y230	4	No	Yes	0	8	9
370	S:S:M388	S:S:Y230	7.18	Yes	Yes	0	8	9
371	S:S:L239	S:S:T241	4.42	No	No	0	5	5
372	S:S:R376	S:S:R379	5.33	No	Yes	6	7	8
373	S:S:D443	S:S:R376	10.72	Yes	No	6	8	7
374	S:S:Q442	S:S:R379	16.35	No	Yes	0	5	8
375	S:S:D443	S:S:R379	5.96	Yes	Yes	6	8	8
376	S:S:F380	S:S:N441	9.67	Yes	Yes	0	8	9
377	S:S:F382	S:S:V386	3.93	No	No	0	7	8
378	S:S:F382	S:S:F440	6.43	No	No	0	7	8
379	S:S:F440	S:S:V383	3.93	No	No	0	8	9
380	S:S:N441	S:S:V383	5.91	Yes	No	0	9	9
381	S:S:I436	S:S:V386	4.61	No	No	0	9	8
382	S:S:N433	S:S:V387	4.43	No	No	0	9	9
383	S:S:I436	S:S:V387	4.61	No	No	0	9	9
384	S:S:I436	S:S:V390	4.61	No	No	0	9	7
385	S:S:W391	S:S:W395	12.18	Yes	Yes	0	9	8
386	S:S:N429	S:S:W391	7.91	No	Yes	0	9	9
387	S:S:C394	S:S:N429	9.45	No	No	0	9	9
388	S:S:F399	S:S:W395	9.02	Yes	Yes	0	8	8
389	S:S:G426	S:S:W395	11.26	No	Yes	0	8	8
390	S:S:F396	S:S:P397	4.33	No	No	0	7	9
391	S:S:F396	S:S:F400	10.72	No	No	0	7	7
392	S:S:F422	S:S:P397	10.11	Yes	No	0	6	9
393	S:S:F398	S:S:F399	13.93	Yes	Yes	2	8	8
394	S:S:F398	S:S:Y402	7.22	Yes	Yes	2	8	8
395	S:S:F398	S:S:F419	7.5	Yes	Yes	2	8	5
396	S:S:F398	S:S:F423	8.57	Yes	Yes	2	8	6
397	M:M:?1	S:S:F398	16.01	Yes	Yes	2	0	8
398	M:M:?1	S:S:F399	8.42	Yes	Yes	2	0	8
399	S:S:F400	S:S:L404	8.53	No	No	0	7	6
400	S:S:S401	S:S:V414	8.08	No	No	2	6	6
401	S:S:F419	S:S:S401	3.96	Yes	No	2	5	6
402	S:S:F422	S:S:S401	3.96	Yes	No	2	6	6
403	S:S:F419	S:S:Y402	4.13	Yes	Yes	2	5	8
404	M:M:?1	S:S:Y402	4.87	Yes	Yes	2	0	8
405	S:S:C412	S:S:L404	4.76	No	No	0	7	6
406	S:S:R409	S:S:Y405	14.4	No	No	0	5	4
407	S:S:Q413	S:S:Y405	4.51	No	No	0	2	4
408	S:S:C408	S:S:C412	7.28	No	No	0	7	7
409	S:S:F419	S:S:V414	3.93	Yes	No	2	5	6
410	S:S:G416	S:S:P417	4.06	No	No	0	2	3
411	S:S:F422	S:S:L418	13.4	Yes	No	2	6	5
412	S:S:F419	S:S:F423	4.29	Yes	Yes	2	5	6
413	M:M:?1	S:S:F419	4.21	Yes	Yes	2	0	5
414	S:S:F421	S:S:I425	7.54	Yes	No	0	6	8
415	S:S:F423	S:S:W424	4.01	Yes	Yes	2	6	8
416	M:M:?1	S:S:F423	15.16	Yes	Yes	2	0	6
417	S:S:W424	S:S:Y427	12.54	Yes	Yes	2	8	8
418	S:S:N433	S:S:Y437	6.98	No	Yes	0	9	9
419	S:S:F444	S:S:Y437	16.5	Yes	Yes	0	9	9
420	S:S:F448	S:S:T438	6.49	No	No	0	8	9
421	S:S:F440	S:S:V439	11.8	No	No	0	8	7
422	S:S:D443	S:S:N441	8.08	Yes	Yes	0	8	9
423	S:S:F444	S:S:N441	8.46	Yes	Yes	0	9	9
424	S:S:F444	S:S:F448	7.5	Yes	No	0	9	8
425	S:S:K449	S:S:R445	4.95	No	No	0	5	9
426	R:R:A139	R:R:W391	3.89	No	Yes	0	9	9
427	S:S:A139	S:S:W391	3.89	No	Yes	0	9	9
428	R:R:F89	R:R:I172	3.77	Yes	No	0	8	9
429	R:R:I211	R:R:R409	3.76	No	No	0	7	5
430	S:S:I211	S:S:R409	3.76	No	No	0	7	5
431	R:R:A129	R:R:P185	3.74	No	No	0	8	9
432	R:R:A139	R:R:P222	3.74	No	No	0	9	9
433	S:S:A139	S:S:P222	3.74	No	No	0	9	9
434	R:R:K449	R:R:R445	3.71	No	No	0	5	9
435	R:R:F448	R:R:L71	3.65	No	No	0	8	8
436	S:S:T208	S:S:W209	3.64	No	No	0	5	5
437	R:R:P185	R:R:S183	3.56	No	No	0	9	8
438	R:R:P434	R:R:V72	3.53	No	No	0	9	9
439	R:R:P415	R:R:V414	3.53	No	No	0	7	6
440	S:S:P434	S:S:V72	3.53	No	No	0	9	9
441	S:S:P415	S:S:V414	3.53	No	No	0	7	6
442	R:R:L54	R:R:Y46	3.52	No	Yes	0	5	6
443	R:R:P165	R:R:T164	3.5	No	No	0	6	8
444	R:R:Q442	R:R:R445	3.5	No	No	0	5	9
445	S:S:P165	S:S:T164	3.5	No	No	0	6	8
446	S:S:E410	S:S:R409	3.49	No	No	0	4	5
447	R:R:A75	R:R:S447	3.42	No	No	0	9	8
448	R:R:L133	R:R:W176	3.42	No	Yes	0	8	9
449	S:S:G68	S:S:L71	3.42	No	No	0	9	8
450	S:S:A75	S:S:S447	3.42	No	No	0	9	8
451	S:S:L212	S:S:W209	3.42	No	No	0	7	5
452	R:R:A101	R:R:T65	3.36	No	No	0	8	8
453	S:S:A101	S:S:T65	3.36	No	No	0	8	8
454	R:R:C408	R:R:I407	3.27	No	No	0	7	5
455	S:S:C408	S:S:I407	3.27	No	No	0	7	5
456	S:S:S137	S:S:S179	3.26	No	No	0	8	8
457	S:S:A101	S:S:I62	3.25	No	No	0	8	8
458	R:R:S430	R:R:V100	3.23	No	No	0	9	9
459	R:R:V73	R:R:V91	3.21	No	No	0	7	8
460	R:R:V153	R:R:V236	3.21	No	No	0	8	7
461	R:R:S430	R:R:T65	3.2	No	No	0	9	8
462	R:R:R376	R:R:R379	3.2	No	No	0	7	8
463	R:R:C428	R:R:L61	3.17	No	No	0	6	7
464	R:R:I182	R:R:S218	3.1	No	No	0	8	8
465	R:R:I74	R:R:V70	3.07	No	No	0	6	6
466	R:R:I98	R:R:V70	3.07	No	No	0	8	6
467	R:R:M388	R:R:S146	3.07	No	No	0	8	9
468	R:R:I233	R:R:V229	3.07	No	No	0	9	8
469	S:S:I98	S:S:V70	3.07	No	No	0	8	6
470	S:S:M388	S:S:S146	3.07	Yes	No	0	8	9
471	S:S:I98	S:S:T102	3.04	No	No	0	8	6
472	S:S:A84	S:S:Q86	3.03	No	Yes	0	8	8
473	R:R:L432	R:R:S431	3	No	No	0	7	8
474	S:S:L61	S:S:S431	3	No	Yes	0	7	8
475	S:S:L147	S:S:S146	3	No	No	0	8	9
476	S:S:G203	S:S:R192	3	No	No	0	3	5
477	S:S:L432	S:S:S431	3	No	Yes	0	7	8
478	R:R:L113	R:R:V51	2.98	No	No	0	7	5
479	R:R:L77	R:R:V73	2.98	No	No	0	5	7
480	R:R:L90	R:R:V76	2.98	No	No	0	8	9
481	R:R:L177	R:R:V173	2.98	No	No	0	5	6
482	R:R:L204	R:R:V188	2.98	Yes	No	0	7	5
483	S:S:L77	S:S:V91	2.98	No	No	0	5	8
484	S:S:Y230	S:S:Y234	2.98	Yes	No	0	9	6
485	S:S:L239	S:S:V236	2.98	No	No	0	5	7
486	S:S:L103	S:S:T102	2.95	No	No	0	6	6
487	R:R:E158	R:R:V157	2.85	No	No	0	6	7
488	R:R:Q155	R:R:T154	2.83	No	No	0	7	8
489	R:R:G120	R:R:W117	2.81	No	Yes	0	8	9
490	S:S:G120	S:S:W117	2.81	No	Yes	0	8	9
491	R:R:P41	R:R:Y199	2.78	No	Yes	0	3	3
492	R:R:A144	R:R:F89	2.77	No	Yes	0	8	8
493	R:R:L103	R:R:L99	2.77	No	No	0	6	8
494	R:R:L103	R:R:L130	2.77	No	No	0	6	6
495	R:R:A110	R:R:F119	2.77	No	Yes	0	7	7
496	R:R:L224	R:R:L228	2.77	No	No	0	5	5
497	S:S:L113	S:S:L54	2.77	Yes	No	0	7	5
498	S:S:A144	S:S:F89	2.77	No	Yes	0	8	8
499	S:S:A110	S:S:F119	2.77	No	Yes	0	7	7
500	S:S:A180	S:S:F184	2.77	No	Yes	0	7	6
501	R:R:A50	R:R:Y46	2.67	No	Yes	0	5	6
502	S:S:A50	S:S:Y46	2.67	No	Yes	0	5	6
503	R:R:F64	R:R:V435	2.62	No	No	0	5	6
504	R:R:R240	R:R:V236	2.62	No	No	0	8	7
505	S:S:F64	S:S:V435	2.62	No	No	0	5	6
506	R:R:A96	R:R:W176	2.59	No	Yes	0	9	9
507	S:S:A96	S:S:W176	2.59	No	Yes	0	9	9
508	S:S:R167	S:S:T164	2.59	No	No	0	7	8
509	R:R:K238	R:R:Y234	2.39	No	No	0	7	6
510	R:R:Q45	R:R:Y46	2.25	No	Yes	0	2	6
511	R:R:Q201	R:R:Y116	2.25	No	Yes	0	4	4
512	S:S:Q201	S:S:Y116	2.25	No	Yes	0	4	4
513	R:R:F60	R:R:F64	2.14	No	No	0	4	5
514	S:S:F119	S:S:Y118	2.06	Yes	No	4	7	5
515	R:R:A115	R:R:G44	1.95	No	No	0	6	5
516	R:R:A52	R:R:G53	1.95	No	No	0	6	4
517	R:R:A56	R:R:G53	1.95	No	No	0	5	4
518	S:S:A115	S:S:G44	1.95	No	No	0	6	5
519	S:S:A52	S:S:G53	1.95	No	No	0	6	4
520	S:S:A56	S:S:G53	1.95	No	No	0	5	4
521	S:S:P185	S:S:P186	1.95	No	No	0	9	8
522	R:R:C143	R:R:P222	1.88	No	No	0	8	9
523	S:S:C143	S:S:P222	1.88	No	No	0	8	9
524	R:R:A84	R:R:P85	1.87	No	No	0	8	7
525	R:R:A197	R:R:P200	1.87	No	No	0	4	4
526	R:R:A221	R:R:P222	1.87	No	No	0	7	9
527	S:S:A221	S:S:P222	1.87	No	No	0	7	9
528	S:S:G49	S:S:S47	1.86	No	No	0	4	6
529	R:R:G68	R:R:V67	1.84	No	No	0	9	6
530	S:S:G68	S:S:V67	1.84	No	No	0	9	6
531	R:R:A411	R:R:C408	1.81	No	No	0	3	7
532	S:S:A411	S:S:C408	1.81	No	No	0	3	7
533	S:S:P186	S:S:V181	1.77	No	No	0	8	5
534	R:R:G217	R:R:I182	1.76	No	No	0	6	8
535	R:R:G217	R:R:I216	1.76	No	No	0	6	5
536	S:S:G217	S:S:I182	1.76	No	No	0	6	8
537	R:R:G227	R:R:M226	1.75	No	No	0	6	9
538	S:S:G227	S:S:M226	1.75	No	No	0	6	9
539	S:S:G389	S:S:M388	1.75	No	Yes	0	7	8
540	R:R:C124	R:R:S189	1.72	No	No	0	9	6
541	R:R:A50	R:R:S47	1.71	No	No	0	5	6
542	R:R:G203	R:R:L128	1.71	No	Yes	0	3	7
543	R:R:A411	S:S:S47	1.71	No	No	0	3	6
544	S:S:A50	S:S:S47	1.71	No	No	0	5	6
545	R:R:A101	R:R:V66	1.7	No	No	0	8	7
546	S:S:A101	S:S:V66	1.7	No	No	0	8	7
547	R:R:K169	R:R:P165	1.67	No	No	0	5	6
548	S:S:A221	S:S:I216	1.62	No	No	0	7	5
549	R:R:A110	R:R:M114	1.61	No	No	0	7	6
550	R:R:A237	R:R:K378	1.61	No	No	0	8	7
551	R:R:V57	R:R:V58	1.6	No	No	0	6	7
552	R:R:V63	R:R:V67	1.6	No	No	0	5	6
553	R:R:S447	R:R:T78	1.6	No	No	0	8	7
554	S:S:V63	S:S:V67	1.6	No	No	0	5	6
555	R:R:T154	R:R:V236	1.59	No	No	0	8	7
556	S:S:C428	S:S:L61	1.59	No	No	0	6	7
557	R:R:A55	R:R:L109	1.58	No	No	0	6	8
558	R:R:A180	R:R:L133	1.58	No	No	0	7	8
559	S:S:A55	S:S:L109	1.58	No	No	0	6	8
560	S:S:I74	S:S:T78	1.52	No	No	0	6	7
561	S:S:A373	S:S:Q374	1.52	No	No	0	5	5
562	R:R:L190	R:R:S189	1.5	No	No	0	5	6
563	S:S:L54	S:S:V57	1.49	No	No	0	5	6
564	S:S:L161	S:S:V157	1.49	No	No	0	6	7
565	S:S:F184	S:S:P185	1.44	Yes	No	0	6	9
566	R:R:P200	R:R:Y199	1.39	No	Yes	0	4	3
567	S:S:P42	S:S:Y116	1.39	No	Yes	0	4	4
568	R:R:A375	R:R:R379	1.38	No	No	0	6	8
569	S:S:A375	S:S:R379	1.38	No	Yes	0	6	8
570	R:R:E158	R:R:K162	1.35	No	No	0	6	5
571	R:R:A237	R:R:Y234	1.33	No	No	0	8	6
572	S:S:A237	S:S:Y234	1.33	No	No	0	8	6
573	S:S:R43	S:S:V51	1.31	No	No	0	1	5
574	R:R:R166	R:R:T164	1.29	No	No	0	7	8
575	S:S:R445	S:S:T438	1.29	No	No	0	9	9
576	R:R:S213	R:R:W209	1.24	No	No	0	7	5
577	S:S:K378	S:S:R240	1.24	No	No	0	7	8
578	S:S:L77	S:S:R83	1.21	No	No	0	5	8
579	S:S:K162	S:S:Y159	1.19	No	No	0	5	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y46	5.35	5	0	6
2	R:R:F89	4.68	6	0	8
3	R:R:M105	6.41	4	1	8
4	R:R:F107	10.24	4	1	7
5	R:R:Y116	8.605	4	7	4
6	R:R:W117	8.78	8	1	9
7	R:R:F119	7.734	5	1	7
8	R:R:W123	8.72	5	1	5
9	R:R:Y127	6.31833	6	1	5
10	R:R:L128	3.8275	4	0	7
11	R:R:H141	6.7525	4	8	8
12	R:R:D148	8.075	4	3	9
13	R:R:R149	7.1	5	3	9
14	R:R:Y150	7.6875	4	0	9
15	R:R:R163	11.02	6	3	8
16	R:R:W176	5.435	6	8	9
17	R:R:Y199	9.6825	4	7	3
18	R:R:L204	4.9225	4	0	7
19	R:R:Y210	7.994	5	0	7
20	R:R:F219	10.196	5	0	8
21	R:R:Y230	7.64	4	0	9
22	R:R:F380	6.0125	4	3	8
23	R:R:W391	7.27667	6	0	9
24	R:R:W395	9.18	4	0	8
25	R:R:F398	10.79	5	1	8
26	R:R:F399	10.63	5	1	8
27	R:R:Y402	8.08	6	1	8
28	R:R:F421	7.535	4	2	6
29	R:R:F422	6.6475	4	2	6
30	R:R:F423	8.58	4	1	6
31	R:R:W424	7.3075	4	1	8
32	R:R:Y427	8.188	5	1	8
33	R:R:Y437	8.302	5	3	9
34	R:R:F440	5.005	4	9	8
35	R:R:D443	6.892	5	0	8
36	R:R:F444	10.2	5	3	9
37	S:S:Y46	7.195	4	0	6
38	S:S:Q86	9.15333	6	5	8
39	S:S:N87	5.585	4	0	9
40	S:S:F89	4.8825	4	0	8
41	S:S:F107	10.2675	4	4	7
42	S:S:L113	6.095	4	0	7
43	S:S:Y116	3.512	5	4	4
44	S:S:W117	9.055	8	4	9
45	S:S:F119	8.4325	4	4	7
46	S:S:W123	9.41	4	4	5
47	S:S:Y127	7.265	4	4	5
48	S:S:F134	8.075	4	0	7
49	S:S:H141	7.075	4	10	8
50	S:S:R149	10.0375	4	5	9
51	S:S:R163	7.37167	6	5	8
52	S:S:W176	5.838	5	10	9
53	S:S:F184	4.29	6	11	6
54	S:S:Y210	8.525	4	0	7
55	S:S:F219	9.752	5	0	8
56	S:S:Y230	6.006	5	0	9
57	S:S:E377	7.505	4	5	8
58	S:S:R379	7.255	4	6	8
59	S:S:F380	8.4375	4	5	8
60	S:S:M388	5.252	5	12	8
61	S:S:W391	6.81	6	0	9
62	S:S:W395	10.7275	4	0	8
63	S:S:F398	10.646	5	2	8
64	S:S:F399	11.398	5	2	8
65	S:S:Y402	6.88	6	2	8
66	S:S:F419	4.67	6	2	5
67	S:S:F421	6.6975	4	2	6
68	S:S:F422	9.01	4	2	6
69	S:S:F423	8.0075	4	2	6
70	S:S:W424	7.445	4	2	8
71	S:S:Y427	9.1925	4	2	8
72	S:S:S431	3.69	4	0	8
73	S:S:Y437	10.0625	4	0	9
74	S:S:N441	8.03	4	0	9
75	S:S:D443	7.735	4	6	8
76	S:S:F444	11.16	4	0	9
77	L:L:?1	9.745	12	1	0
78	M:M:?1	9.72	11	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y127	27.9893	4.05	Yes	Yes	1	0	5
2	R:R:F107	R:R:Y127	10.2608	6.19	Yes	Yes	1	7	5
3	R:R:F119	R:R:Y118	11.0416	4.13	Yes	No	0	7	5
4	R:R:W117	R:R:Y127	14.3023	11.58	Yes	Yes	1	9	5
5	R:R:P434	R:R:V72	11.9547	3.53	No	No	0	9	9
6	R:R:V72	R:R:Y437	12.6477	5.05	No	Yes	0	9	9
7	R:R:F444	R:R:Y437	23.5804	18.57	Yes	Yes	3	9	9
8	R:R:F380	R:R:F444	33.0335	4.29	Yes	Yes	3	8	9
9	R:R:F380	R:R:R149	39.4911	6.41	Yes	Yes	3	8	9
10	R:R:R149	R:R:R163	42.0589	4.26	Yes	Yes	3	9	8
11	R:R:R163	R:R:Y159	50.5378	10.29	Yes	No	3	8	9
12	R:R:W151	R:R:Y159	75.7403	12.54	No	No	0	5	9
13	R:R:W151	R:R:Y150	76.8993	4.82	No	Yes	0	5	9
14	R:R:I233	R:R:Y150	81.4895	4.84	No	Yes	0	9	9
15	R:R:I233	R:R:Y230	81.9156	10.88	No	Yes	0	9	9
16	R:R:M388	R:R:Y230	85.2967	8.38	No	Yes	0	8	9
17	R:R:L142	R:R:M388	87.1247	9.9	No	No	0	9	8
18	R:R:L142	R:R:W391	88.793	7.97	No	Yes	0	9	9
19	R:R:F219	R:R:W391	42.9658	4.01	Yes	Yes	0	8	9
20	R:R:F219	R:R:F399	44.3774	22.51	Yes	Yes	0	8	8
21	L:L:?1	R:R:F399	22.5948	7.58	Yes	Yes	1	0	8
22	R:R:W391	R:R:W395	50.8692	10.31	Yes	Yes	0	9	8
23	R:R:F399	R:R:W395	40.9604	6.01	Yes	Yes	0	8	8
24	R:R:C135	R:R:W395	10.4547	9.14	No	Yes	0	8	8
25	L:L:?1	R:R:C135	10.773	6.59	Yes	No	0	0	8
26	R:R:A84	R:R:Q86	13.4998	4.55	No	No	0	8	8
27	R:R:D148	R:R:Y159	24.6207	9.2	Yes	No	3	9	9
28	R:R:P165	R:R:P85	10.8089	7.79	No	No	0	6	7
29	R:R:A84	R:R:P85	12.1549	1.87	No	No	0	8	7
30	R:R:D148	R:R:F89	17.1114	4.78	Yes	Yes	0	9	8
31	R:R:I172	R:R:S92	13.2745	7.74	No	No	0	9	9
32	R:R:F89	R:R:I172	13.9618	3.77	Yes	No	0	8	9
33	L:L:?1	R:R:Y402	17.1963	8.11	Yes	Yes	1	0	8
34	R:R:F422	R:R:S401	55.5713	3.96	Yes	No	0	6	6
35	R:R:S401	R:R:V414	55.6825	9.7	No	No	0	6	6
36	R:R:F419	R:R:V414	86.0365	3.93	No	No	0	5	6
37	R:R:F398	R:R:F419	69.9358	8.57	Yes	No	1	8	5
38	L:L:?1	R:R:F398	12.3249	12.64	Yes	Yes	1	0	8
39	R:R:F419	R:R:Y402	16.2096	4.13	No	Yes	1	5	8
40	R:R:P415	R:R:V414	30.3066	3.53	No	No	0	7	6
41	R:R:P417	S:S:P417	31.1382	11.69	No	No	0	3	3
42	R:R:P415	S:S:P417	30.5753	7.79	No	No	0	7	3
43	R:R:P417	S:S:P415	31.6966	7.79	No	No	0	3	7
44	R:R:F421	S:S:F421	55.0243	4.29	Yes	Yes	2	6	6
45	R:R:F422	S:S:F421	55.0602	6.43	Yes	Yes	2	6	6
46	R:R:F421	S:S:F422	54.5201	8.57	Yes	Yes	2	6	6
47	S:S:P415	S:S:V414	31.9823	3.53	No	No	0	7	6
48	S:S:F419	S:S:V414	31.9162	3.93	Yes	No	2	5	6
49	M:M:?1	S:S:F419	20.5329	4.21	Yes	Yes	2	0	5
50	M:M:?1	S:S:L204	21.4301	5.74	Yes	No	0	0	7
51	S:S:L128	S:S:L204	20.0624	5.54	No	No	0	7	7
52	S:S:L128	S:S:Y127	19.4601	4.69	No	Yes	0	7	5
53	S:S:W117	S:S:Y127	11.0946	11.58	Yes	Yes	4	9	5
54	S:S:F423	S:S:W424	25.7591	4.01	Yes	Yes	2	6	8
55	S:S:V58	S:S:W424	14.0388	8.58	No	Yes	0	7	8
56	S:S:L109	S:S:V58	13.4394	10.43	No	No	0	8	7
57	S:S:L109	S:S:L113	12.3295	8.3	No	Yes	0	8	7
58	S:S:M105	S:S:W424	11.1733	4.65	No	Yes	2	8	8
59	S:S:I62	S:S:M105	14.5025	4.37	No	No	0	8	8
60	S:S:A101	S:S:I62	12.0968	3.25	No	No	0	8	8
61	S:S:F422	S:S:P397	53.8391	10.11	Yes	No	0	6	9
62	S:S:F396	S:S:P397	53.6252	4.33	No	No	0	7	9
63	S:S:F219	S:S:F396	52.8153	4.29	Yes	No	0	8	7
64	S:S:F219	S:S:W391	71.4296	5.01	Yes	Yes	0	8	9
65	S:S:L142	S:S:W391	100	5.69	No	Yes	0	9	9
66	S:S:L142	S:S:M388	98.2268	8.48	No	Yes	12	9	8
67	S:S:M388	S:S:Y230	93.5663	7.18	Yes	Yes	0	8	9
68	S:S:T381	S:S:Y230	90.8372	4.99	No	Yes	0	8	9
69	S:S:R149	S:S:T381	90.2879	12.94	Yes	No	0	9	8
70	S:S:F380	S:S:R149	74.072	8.55	Yes	Yes	5	8	9
71	S:S:F380	S:S:N87	38.0624	9.67	Yes	Yes	0	8	9
72	S:S:L90	S:S:N87	30.5114	4.12	No	Yes	0	8	9
73	S:S:L90	S:S:Y437	24.8905	11.72	No	Yes	0	8	9
74	S:S:V72	S:S:Y437	43.2897	5.05	No	Yes	0	9	9
75	S:S:P434	S:S:V72	41.9961	3.53	No	No	0	9	9
76	S:S:G68	S:S:P434	10.6081	4.06	No	No	0	9	9
77	S:S:F380	S:S:N441	36.7756	9.67	Yes	Yes	0	8	9
78	S:S:F444	S:S:N441	28.0206	8.46	Yes	Yes	0	9	9
79	S:S:F444	S:S:Y437	24.9835	16.5	Yes	Yes	0	9	9
80	S:S:N69	S:S:P434	30.3026	11.4	No	No	0	9	9
81	S:S:D97	S:S:N69	27.6915	6.73	No	No	0	9	9
82	S:S:P85	S:S:R163	10.6766	7.21	No	Yes	0	7	8
83	S:S:D97	S:S:S430	26.3843	10.31	No	No	0	9	9
84	S:S:S430	S:S:V100	25.0759	4.85	No	No	0	9	9
85	S:S:F134	S:S:V100	23.7663	3.93	Yes	No	0	7	9
86	S:S:F134	S:S:W176	14.5676	4.01	Yes	Yes	0	7	9
87	M:M:?1	S:S:C135	14.1763	6.59	Yes	No	0	0	8
88	S:S:F398	S:S:F399	13.3419	13.93	Yes	Yes	2	8	8
89	S:S:F399	S:S:W395	21.9149	9.02	Yes	Yes	0	8	8
90	M:M:?1	S:S:F399	28.4033	8.42	Yes	Yes	2	0	8
91	S:S:C135	S:S:W395	13.9162	10.45	No	Yes	0	8	8
92	S:S:I211	S:S:Y402	10.1992	15.71	No	Yes	0	7	8
93	R:R:F398	R:R:F399	59.7959	12.86	Yes	Yes	1	8	8
94	S:S:F219	S:S:F399	22.1134	21.43	Yes	Yes	0	8	8
95	M:M:?1	S:S:F423	12.504	15.16	Yes	Yes	2	0	6
96	S:S:W391	S:S:W395	33.8799	12.18	Yes	Yes	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:D131	S:S:V104	4.38	0	No	No	9	9	1	2
S:S:L128	S:S:L204	5.54	0	No	No	7	7	2	1
S:S:D131	S:S:Y427	5.75	0	No	Yes	9	8	1	2
M:M:?1	S:S:D131	26.28	2	Yes	No	0	9	0	1
S:S:V132	S:S:Y191	10.09	0	No	No	8	5	1	2
M:M:?1	S:S:V132	11.34	2	Yes	No	0	8	0	1
S:S:C135	S:S:W395	10.45	0	No	Yes	8	8	1	2
M:M:?1	S:S:C135	6.59	2	Yes	No	0	8	0	1
S:S:S218	S:S:T136	9.59	0	No	No	8	8	1	2
S:S:L204	S:S:Y210	8.21	0	No	Yes	7	7	1	2
M:M:?1	S:S:L204	5.74	2	Yes	No	0	7	0	1
S:S:S214	S:S:Y210	11.45	0	No	Yes	8	7	1	2
S:S:Y210	S:S:Y402	3.97	0	Yes	Yes	7	8	2	1
S:S:I211	S:S:Y402	15.71	0	No	Yes	7	8	2	1
M:M:?1	S:S:S214	4.15	2	Yes	No	0	8	0	1
S:S:C215	S:S:F399	4.19	0	No	Yes	8	8	2	1
S:S:C215	S:S:Y402	5.38	0	No	Yes	8	8	2	1
M:M:?1	S:S:S218	4.15	2	Yes	No	0	8	0	1
S:S:F219	S:S:F399	21.43	0	Yes	Yes	8	8	2	1
S:S:F399	S:S:W395	9.02	2	Yes	Yes	8	8	1	2
S:S:F398	S:S:F399	13.93	2	Yes	Yes	8	8	1	1
S:S:F398	S:S:Y402	7.22	2	Yes	Yes	8	8	1	1
S:S:F398	S:S:F419	7.5	2	Yes	Yes	8	5	1	1
S:S:F398	S:S:F423	8.57	2	Yes	Yes	8	6	1	1
M:M:?1	S:S:F398	16.01	2	Yes	Yes	0	8	0	1
M:M:?1	S:S:F399	8.42	2	Yes	Yes	0	8	0	1
S:S:S401	S:S:V414	8.08	2	No	No	6	6	2	2
S:S:F419	S:S:S401	3.96	2	Yes	No	5	6	1	2
S:S:F419	S:S:Y402	4.13	2	Yes	Yes	5	8	1	1
M:M:?1	S:S:Y402	4.87	2	Yes	Yes	0	8	0	1
S:S:F419	S:S:V414	3.93	2	Yes	No	5	6	1	2
S:S:F419	S:S:F423	4.29	2	Yes	Yes	5	6	1	1
M:M:?1	S:S:F419	4.21	2	Yes	Yes	0	5	0	1
S:S:F423	S:S:W424	4.01	2	Yes	Yes	6	8	1	2
M:M:?1	S:S:F423	15.16	2	Yes	Yes	0	6	0	1
S:S:W424	S:S:Y427	12.54	2	Yes	Yes	8	8	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V104	R:R:Y127	6.31	0	No	Yes	9	5	2	1
R:R:D131	R:R:V104	5.84	1	No	No	9	9	1	2
R:R:M105	R:R:W424	5.82	1	Yes	Yes	8	8	2	2
R:R:M105	R:R:Y427	8.38	1	Yes	Yes	8	8	2	1
R:R:F107	R:R:W117	4.01	1	Yes	Yes	7	9	2	2
R:R:F107	R:R:Y127	6.19	1	Yes	Yes	7	5	2	1
R:R:S108	R:R:Y127	5.09	0	No	Yes	8	5	2	1
R:R:S108	R:R:Y427	7.63	0	No	Yes	8	8	2	1
R:R:W117	R:R:Y127	11.58	1	Yes	Yes	9	5	2	1
R:R:L128	R:R:Y127	4.69	0	Yes	Yes	7	5	2	1
L:L:?1	R:R:Y127	4.05	1	Yes	Yes	0	5	0	1
R:R:L128	R:R:L204	4.15	0	Yes	Yes	7	7	2	1
R:R:D131	R:R:Y427	5.75	1	No	Yes	9	8	1	1
L:L:?1	R:R:D131	29.1	1	Yes	No	0	9	0	1
R:R:S183	R:R:V132	4.85	0	No	No	8	8	2	1
L:L:?1	R:R:V132	11.34	1	Yes	No	0	8	0	1
R:R:C135	R:R:W395	9.14	0	No	Yes	8	8	1	2
L:L:?1	R:R:C135	6.59	1	Yes	No	0	8	0	1
R:R:S183	R:R:T136	6.4	0	No	No	8	8	2	2
R:R:S218	R:R:T136	9.59	0	No	No	8	8	1	2
R:R:L204	R:R:Y210	5.86	0	Yes	Yes	7	7	1	2
L:L:?1	R:R:L204	6.7	1	Yes	Yes	0	7	0	1
R:R:S214	R:R:Y210	12.72	0	No	Yes	8	7	1	2
R:R:Y210	R:R:Y402	3.97	0	Yes	Yes	7	8	2	1
R:R:I211	R:R:Y402	14.51	0	No	Yes	7	8	2	1
L:L:?1	R:R:S214	4.15	1	Yes	No	0	8	0	1
R:R:C215	R:R:F399	4.19	0	No	Yes	8	8	2	1
R:R:C215	R:R:Y402	5.38	0	No	Yes	8	8	2	1
L:L:?1	R:R:S218	4.15	1	Yes	No	0	8	0	1
R:R:F219	R:R:F399	22.51	0	Yes	Yes	8	8	2	1
R:R:F399	R:R:W395	6.01	1	Yes	Yes	8	8	1	2
R:R:F398	R:R:F399	12.86	1	Yes	Yes	8	8	1	1
R:R:F398	R:R:Y402	12.38	1	Yes	Yes	8	8	1	1
R:R:F398	R:R:F419	8.57	1	Yes	No	8	5	1	2
R:R:F398	R:R:F423	7.5	1	Yes	Yes	8	6	1	1
L:L:?1	R:R:F398	12.64	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F399	7.58	1	Yes	Yes	0	8	0	1
R:R:F419	R:R:Y402	4.13	1	No	Yes	5	8	2	1
L:L:?1	R:R:Y402	8.11	1	Yes	Yes	0	8	0	1
R:R:F423	R:R:K420	4.96	1	Yes	No	6	5	1	2
R:R:F423	R:R:W424	5.01	1	Yes	Yes	6	8	1	2
L:L:?1	R:R:F423	16.85	1	Yes	Yes	0	6	0	1
R:R:W424	R:R:Y427	13.5	1	Yes	Yes	8	8	2	1
L:L:?1	R:R:Y427	5.68	1	Yes	Yes	0	8	0	1
R:R:I182	R:R:S218	3.1	0	No	No	8	8	2	1
R:R:L204	R:R:V188	2.98	0	Yes	No	7	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6KUW_poly
Class	A
SubFamily	Amine
Type	Adrenergic
SubType	Alpha2C
Species	Homo sapiens
Ligand	PubChem 57213234
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	2.8
Date	2019-12-04
D.O.I.	10.1038/nature06325

Net Summary
I_min	3.93
Number of Linked Nodes	510
Number of Links	579
Number of Hubs	78
Number of Links mediated by Hubs	295
Number of Communities	13
Number of Nodes involved in Communities	92
Number of Links involved in Communities	128

Path Summary
Number Of Nodes in MetaPath	97
Number Of Links MetaPath	96
Number of Shortest Paths	373541
Length Of Smallest Path	3
Average Path Length	22.4325
Length of Longest Path	57
Minimum Path Strength	1.47
Average Path Strength	7.56722
Maximum Path Strength	22.975
Minimum Path Correlation	0.7
Average Path Correlation	0.963107
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.85714
Average % Of Corr. Nodes	47.7256
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.8783
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	E33
PDB Residues	L:L:?1 M:M:?1
Environment Details	Open EMBL-EBI Page
Code	E33
Name	(8~{a}~{R},12~{a}~{S},13~{a}~{R})-12-ethylsulfonyl-3-methoxy-5,6,8,8~{a},9,10,11,12~{a},13,13~{a}-decahydroisoquinolino[2,1-g][1,6]naphthyridine
Synonyms
Identifier	(8~{a}~{R},12~{a}~{S},13~{a}~{R})-12-ethylsulfonyl-3-methoxy-5,6,8,8~{a},9,10,11,12~{a},13,13~{a}-decahydroisoquinolino[2,1-g][1,6]naphthyridine
Formula	C19 H28 N2 O3 S
Molecular Weight	364.502
SMILES	CCS(=O)(=O)N1CCC[C@H]2[C@@H]1C[C@@H]3c4ccc(cc4CCN3C2)OC
PubChem	57213234
Formal Charge	0
Total Atoms	53
Total Chiral Atoms	3
Total Bonds	56
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P18825
Sequence	>6KUW_poly_Chain_R P P R G Q Y S A G A V A G L A A V V G F L I V F T V V G N V L V V I A V L T S R A L R A P Q N L F L V S L A S A D I L V A T L V M P F S L A N E L M A Y W Y F G Q W W C G V Y L A L D V L F C T S S A V H L C A I S L D R Y W S V T Q A V E Y N L K R T P R R V K A T I V A V W L I S A V I S F P P L V S L A A Y P Q C G L N D E T W Y I L S S C I G S F F A P C L I M G L V Y A R I Y R V A K L R T V A Q A R E K R F T F V L A V V M G V W V L C W F P F F F S Y S L Y G I C R E A C Q V P G P L F K F F F W I G Y C N S S L N P V I Y T V F N Q D F R R S F K H I L F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6KUW	A	Amine	Adrenergic	α_2c	Homo sapiens	PubChem 57213234	-	-	2.8	2019-12-04	10.1038/nature06325
	6KUW (Dimer)	A	Amine	Adrenergic	α_2c	Homo sapiens	PubChem 57213234	-	-	2.8	2019-12-04	10.1038/nature06325

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Download 6KUW_poly.zip

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