psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y127	4.05	Yes	Yes	1	0	5
2	L:L:?1	R:R:D131	29.1	Yes	No	1	0	9
3	L:L:?1	R:R:V132	11.34	Yes	No	0	0	8
4	L:L:?1	R:R:C135	6.59	Yes	No	0	0	8
5	L:L:?1	R:R:L204	6.7	Yes	Yes	0	0	7
6	L:L:?1	R:R:S214	4.15	Yes	No	0	0	8
7	L:L:?1	R:R:S218	4.15	Yes	No	0	0	8
8	L:L:?1	R:R:F398	12.64	Yes	Yes	1	0	8
9	L:L:?1	R:R:F399	7.58	Yes	Yes	1	0	8
10	L:L:?1	R:R:Y402	8.11	Yes	Yes	1	0	8
11	L:L:?1	R:R:F423	16.85	Yes	Yes	1	0	6
12	L:L:?1	R:R:Y427	5.68	Yes	Yes	1	0	8
13	M:M:?1	S:S:D131	26.28	Yes	No	0	0	9
14	M:M:?1	S:S:V132	11.34	Yes	No	0	0	8
15	M:M:?1	S:S:C135	6.59	Yes	No	0	0	8
16	M:M:?1	S:S:L204	5.74	Yes	No	0	0	7
17	M:M:?1	S:S:S214	4.15	Yes	No	0	0	8
18	M:M:?1	S:S:S218	4.15	Yes	No	0	0	8
19	M:M:?1	S:S:F398	16.01	Yes	Yes	2	0	8
20	M:M:?1	S:S:F399	8.42	Yes	Yes	2	0	8
21	M:M:?1	S:S:Y402	4.87	Yes	Yes	2	0	8
22	M:M:?1	S:S:F419	4.21	Yes	Yes	2	0	5
23	M:M:?1	S:S:F423	15.16	Yes	Yes	2	0	6
24	R:R:P42	R:R:Y116	8.34	No	Yes	7	4	4
25	R:R:P42	R:R:Y199	16.69	No	Yes	7	4	3
26	R:R:Q45	R:R:Y46	6.76	No	Yes	0	2	6
27	R:R:E112	R:R:Y46	10.1	No	Yes	0	6	6
28	R:R:L113	R:R:Y46	8.21	No	Yes	0	7	6
29	R:R:L109	R:R:V58	10.43	No	No	0	8	7
30	R:R:V58	R:R:W424	4.9	No	Yes	0	7	8
31	R:R:L61	R:R:M105	7.07	No	Yes	0	7	8
32	R:R:I62	R:R:M105	4.37	No	Yes	0	8	8
33	R:R:I62	R:R:P106	5.08	No	No	0	8	9
34	R:R:F64	R:R:S431	5.28	No	No	0	5	8
35	R:R:S431	R:R:T65	4.8	No	No	0	8	8
36	R:R:G68	R:R:P434	4.06	No	No	0	9	9
37	R:R:A94	R:R:N69	4.69	No	No	0	9	9
38	R:R:D97	R:R:N69	12.12	No	No	0	9	9
39	R:R:N69	R:R:P434	11.4	No	No	0	9	9
40	R:R:I451	R:R:L71	4.28	No	No	0	8	8
41	R:R:L452	R:R:L71	4.15	No	No	0	8	8
42	R:R:V72	R:R:Y437	5.05	No	Yes	0	9	9
43	R:R:I451	R:R:I74	4.42	No	No	0	8	6
44	R:R:V76	R:R:V91	4.81	No	No	0	9	8
45	R:R:L82	R:R:S79	9.01	No	No	0	9	7
46	R:R:S447	R:R:S79	4.89	No	No	0	8	7
47	R:R:A81	R:R:D443	6.18	No	Yes	0	7	8
48	R:R:D443	R:R:L82	4.07	Yes	No	0	8	9
49	R:R:F444	R:R:L82	12.18	Yes	No	0	9	9
50	R:R:A84	R:R:Q86	4.55	No	No	0	8	8
51	R:R:P165	R:R:P85	7.79	No	No	0	6	7
52	R:R:D148	R:R:Q86	5.22	Yes	No	3	9	8
53	R:R:Q86	R:R:R163	24.53	No	Yes	3	8	8
54	R:R:L90	R:R:N87	5.49	No	No	0	8	9
55	R:R:L88	R:R:V168	4.47	No	No	0	7	8
56	R:R:F89	R:R:I145	5.02	Yes	No	0	8	9
57	R:R:D148	R:R:F89	4.78	Yes	Yes	0	9	8
58	R:R:F89	R:R:V168	6.55	Yes	No	0	8	8
59	R:R:F89	R:R:T171	5.19	Yes	No	0	8	7
60	R:R:L90	R:R:Y437	7.03	No	Yes	0	8	9
61	R:R:H141	R:R:S92	8.37	Yes	No	8	8	9
62	R:R:I172	R:R:S92	7.74	No	No	0	9	9
63	R:R:S92	R:R:W176	6.18	No	Yes	8	9	9
64	R:R:H141	R:R:L93	6.43	Yes	No	0	8	9
65	R:R:D97	R:R:S430	8.83	No	No	0	9	9
66	R:R:F134	R:R:L99	8.53	No	No	0	7	8
67	R:R:L103	R:R:T102	4.42	No	No	0	6	6
68	R:R:V104	R:R:Y127	6.31	No	Yes	0	9	5
69	R:R:D131	R:R:V104	5.84	No	No	0	9	9
70	R:R:M105	R:R:W424	5.82	Yes	Yes	1	8	8
71	R:R:M105	R:R:Y427	8.38	Yes	Yes	1	8	8
72	R:R:F107	R:R:W117	4.01	Yes	Yes	1	7	9
73	R:R:F107	R:R:F119	10.72	Yes	Yes	1	7	7
74	R:R:F107	R:R:W123	20.04	Yes	Yes	1	7	5
75	R:R:F107	R:R:Y127	6.19	Yes	Yes	1	7	5
76	R:R:S108	R:R:Y127	5.09	No	Yes	0	8	5
77	R:R:S108	R:R:Y427	7.63	No	Yes	0	8	8
78	R:R:L109	R:R:L113	8.3	No	No	0	8	7
79	R:R:N111	R:R:W117	7.91	No	Yes	0	6	9
80	R:R:E112	R:R:K420	13.5	No	No	0	6	5
81	R:R:Y116	R:R:Y118	5.96	Yes	No	0	4	5
82	R:R:Y116	R:R:Y199	17.87	Yes	Yes	7	4	3
83	R:R:F119	R:R:W117	17.04	Yes	Yes	1	7	9
84	R:R:W117	R:R:W123	4.69	Yes	Yes	1	9	5
85	R:R:C124	R:R:W117	5.22	No	Yes	1	9	9
86	R:R:W117	R:R:Y127	11.58	Yes	Yes	1	9	5
87	R:R:C202	R:R:W117	16.98	No	Yes	1	9	9
88	R:R:F119	R:R:Y118	4.13	Yes	No	0	7	5
89	R:R:F119	R:R:W123	4.01	Yes	Yes	1	7	5
90	R:R:W122	R:R:W123	7.5	No	Yes	1	5	5
91	R:R:V126	R:R:W122	6.13	No	No	1	6	5
92	R:R:V126	R:R:W123	7.36	No	Yes	1	6	5
93	R:R:C124	R:R:C202	7.28	No	No	1	9	9
94	R:R:L128	R:R:Y127	4.69	Yes	Yes	0	7	5
95	R:R:C202	R:R:L128	4.76	No	Yes	0	9	7
96	R:R:L128	R:R:L204	4.15	Yes	Yes	0	7	7
97	R:R:F134	R:R:L130	12.18	No	No	0	7	6
98	R:R:D131	R:R:Y427	5.75	No	Yes	1	9	8
99	R:R:S183	R:R:V132	4.85	No	No	0	8	8
100	R:R:F134	R:R:W176	4.01	No	Yes	0	7	9
101	R:R:C135	R:R:W395	9.14	No	Yes	0	8	8
102	R:R:S183	R:R:T136	6.4	No	No	0	8	8
103	R:R:S218	R:R:T136	9.59	No	No	0	8	8
104	R:R:S137	R:R:W176	11.12	No	Yes	0	8	9
105	R:R:S137	R:R:S179	6.52	No	No	0	8	8
106	R:R:S138	R:R:W391	6.18	No	Yes	0	9	9
107	R:R:V140	R:R:V175	4.81	No	No	0	8	8
108	R:R:I178	R:R:V140	4.61	No	No	0	6	8
109	R:R:S179	R:R:V140	4.85	No	No	0	8	8
110	R:R:H141	R:R:V175	6.92	Yes	No	0	8	8
111	R:R:H141	R:R:W176	5.29	Yes	Yes	8	8	9
112	R:R:L142	R:R:M226	7.07	No	No	0	9	9
113	R:R:L142	R:R:M388	9.9	No	No	0	9	8
114	R:R:L142	R:R:W391	7.97	No	Yes	0	9	9
115	R:R:C143	R:R:I225	4.91	No	No	0	8	7
116	R:R:I145	R:R:L384	5.71	No	No	0	9	8
117	R:R:S146	R:R:V229	8.08	No	No	0	9	8
118	R:R:L147	R:R:W151	9.11	No	No	0	8	5
119	R:R:D148	R:R:Y159	9.2	Yes	No	3	9	9
120	R:R:D148	R:R:R163	13.1	Yes	Yes	3	9	8
121	R:R:R149	R:R:R163	4.26	Yes	Yes	3	9	8
122	R:R:E377	R:R:R149	5.82	No	Yes	0	8	9
123	R:R:F380	R:R:R149	6.41	Yes	Yes	3	8	9
124	R:R:R149	R:R:T381	12.94	Yes	No	0	9	8
125	R:R:L384	R:R:R149	6.07	No	Yes	3	8	9
126	R:R:W151	R:R:Y150	4.82	No	Yes	0	5	9
127	R:R:T154	R:R:Y150	8.74	No	Yes	0	8	9
128	R:R:R232	R:R:Y150	12.35	No	Yes	0	7	9
129	R:R:I233	R:R:Y150	4.84	No	Yes	0	9	9
130	R:R:W151	R:R:Y159	12.54	No	No	0	5	9
131	R:R:R163	R:R:S152	7.91	Yes	No	0	8	8
132	R:R:R163	R:R:Y159	10.29	Yes	No	3	8	9
133	R:R:N160	R:R:R163	6.03	No	Yes	0	7	8
134	R:R:K162	R:R:R167	11.14	No	No	0	5	7
135	R:R:R167	R:R:T164	5.17	No	No	0	7	8
136	R:R:F184	R:R:P186	18.78	No	No	0	6	8
137	R:R:P185	R:R:P186	5.84	No	No	0	9	8
138	R:R:L204	R:R:Y210	5.86	Yes	Yes	0	7	7
139	R:R:E207	R:R:N205	10.52	No	No	0	6	7
140	R:R:N205	R:R:Y210	11.63	No	Yes	0	7	7
141	R:R:D206	R:R:Y405	6.9	No	No	0	5	4
142	R:R:E207	R:R:W209	8.72	No	No	0	6	5
143	R:R:R409	R:R:T208	6.47	Yes	No	0	5	5
144	R:R:W209	R:R:Y210	5.79	No	Yes	0	5	7
145	R:R:S214	R:R:Y210	12.72	No	Yes	0	8	7
146	R:R:Y210	R:R:Y402	3.97	Yes	Yes	0	7	8
147	R:R:I211	R:R:Y402	14.51	No	Yes	0	7	8
148	R:R:G406	R:R:I211	5.29	No	No	0	7	7
149	R:R:I407	R:R:L212	4.28	No	No	0	5	7
150	R:R:C215	R:R:F399	4.19	No	Yes	0	8	8
151	R:R:C215	R:R:Y402	5.38	No	Yes	0	8	8
152	R:R:F219	R:R:F220	10.72	Yes	No	0	8	7
153	R:R:C223	R:R:F219	8.38	No	Yes	0	7	8
154	R:R:F219	R:R:W391	4.01	Yes	Yes	0	8	9
155	R:R:F219	R:R:F396	5.36	Yes	No	0	8	7
156	R:R:F219	R:R:F399	22.51	Yes	Yes	0	8	8
157	R:R:F220	R:R:S403	6.61	No	No	0	7	7
158	R:R:C223	R:R:V392	5.12	No	No	0	7	8
159	R:R:I233	R:R:Y230	10.88	No	Yes	0	9	9
160	R:R:Y230	R:R:Y234	5.96	Yes	No	0	9	6
161	R:R:A385	R:R:Y230	5.34	No	Yes	0	8	9
162	R:R:M388	R:R:Y230	8.38	No	Yes	0	8	9
163	R:R:L239	R:R:R240	8.5	No	No	0	5	8
164	R:R:D443	R:R:R376	8.34	Yes	No	0	8	7
165	R:R:F380	R:R:L384	7.31	Yes	No	3	8	8
166	R:R:F380	R:R:N441	6.04	Yes	No	3	8	9
167	R:R:F380	R:R:F444	4.29	Yes	Yes	3	8	9
168	R:R:F382	R:R:V386	6.55	No	No	9	7	8
169	R:R:F382	R:R:F440	4.29	No	Yes	9	7	8
170	R:R:F440	R:R:V383	3.93	Yes	No	0	8	9
171	R:R:I436	R:R:V386	4.61	No	No	0	9	8
172	R:R:F440	R:R:V386	3.93	Yes	No	9	8	8
173	R:R:N433	R:R:V387	8.87	No	No	3	9	9
174	R:R:I436	R:R:V387	4.61	No	No	0	9	9
175	R:R:V387	R:R:Y437	5.05	No	Yes	3	9	9
176	R:R:I436	R:R:V390	4.61	No	No	0	9	7
177	R:R:W391	R:R:W395	10.31	Yes	Yes	0	9	8
178	R:R:N429	R:R:W391	11.3	No	Yes	0	9	9
179	R:R:C394	R:R:N429	9.45	No	No	0	9	9
180	R:R:F399	R:R:W395	6.01	Yes	Yes	0	8	8
181	R:R:G426	R:R:W395	11.26	No	Yes	0	8	8
182	R:R:F396	R:R:F400	11.79	No	No	0	7	7
183	R:R:F422	R:R:P397	10.11	Yes	No	0	6	9
184	R:R:F398	R:R:F399	12.86	Yes	Yes	1	8	8
185	R:R:F398	R:R:Y402	12.38	Yes	Yes	1	8	8
186	R:R:F398	R:R:F419	8.57	Yes	No	1	8	5
187	R:R:F398	R:R:F423	7.5	Yes	Yes	1	8	6
188	R:R:F400	R:R:L404	6.09	No	No	0	7	6
189	R:R:S401	R:R:V414	9.7	No	No	0	6	6
190	R:R:F422	R:R:S401	3.96	Yes	No	0	6	6
191	R:R:F419	R:R:Y402	4.13	No	Yes	1	5	8
192	R:R:C412	R:R:L404	4.76	No	No	0	7	6
193	R:R:R409	R:R:Y405	11.32	Yes	No	0	5	4
194	R:R:Q413	R:R:Y405	9.02	No	No	0	2	4
195	R:R:C408	R:R:C412	7.28	No	No	0	7	7
196	R:R:F419	R:R:V414	3.93	No	No	0	5	6
197	R:R:P415	S:S:P417	7.79	No	No	0	7	3
198	R:R:G416	R:R:P417	4.06	No	No	0	2	3
199	R:R:P417	S:S:P415	7.79	No	No	0	3	7
200	R:R:P417	S:S:P417	11.69	No	No	0	3	3
201	R:R:F422	R:R:L418	6.09	Yes	No	2	6	5
202	R:R:L418	S:S:F421	8.53	No	Yes	2	5	6
203	R:R:F423	R:R:K420	4.96	Yes	No	0	6	5
204	R:R:F421	R:R:I425	7.54	Yes	No	0	6	8
205	R:R:F421	S:S:L418	9.74	Yes	No	2	6	5
206	R:R:F421	S:S:F421	4.29	Yes	Yes	2	6	6
207	R:R:F421	S:S:F422	8.57	Yes	Yes	2	6	6
208	R:R:F422	S:S:F421	6.43	Yes	Yes	2	6	6
209	R:R:F423	R:R:W424	5.01	Yes	Yes	1	6	8
210	R:R:W424	R:R:Y427	13.5	Yes	Yes	1	8	8
211	R:R:N433	R:R:Y437	5.81	No	Yes	3	9	9
212	R:R:F444	R:R:Y437	18.57	Yes	Yes	3	9	9
213	R:R:F448	R:R:T438	9.08	No	No	0	8	9
214	R:R:F440	R:R:V439	7.87	Yes	No	0	8	7
215	R:R:D443	R:R:N441	6.73	Yes	No	0	8	9
216	R:R:F444	R:R:N441	8.46	Yes	No	3	9	9
217	R:R:D443	R:R:Q442	9.14	Yes	No	0	8	5
218	R:R:Q442	R:R:R446	5.84	No	No	0	5	5
219	R:R:F444	R:R:F448	7.5	Yes	No	0	9	8
220	R:R:H450	R:R:R454	6.77	No	No	0	6	5
221	R:R:F453	R:R:L452	7.31	No	No	0	4	8
222	S:S:P41	S:S:P42	5.84	No	No	0	3	4
223	S:S:G44	S:S:R43	6	No	No	0	5	1
224	S:S:Q45	S:S:Y46	10.15	No	Yes	0	2	6
225	S:S:E112	S:S:Y46	10.1	No	Yes	0	6	6
226	S:S:L113	S:S:Y46	5.86	Yes	Yes	0	7	6
227	S:S:L113	S:S:V51	7.45	Yes	No	0	7	5
228	S:S:L109	S:S:V58	10.43	No	No	0	8	7
229	S:S:V58	S:S:W424	8.58	No	Yes	0	7	8
230	S:S:F60	S:S:F64	5.36	No	No	0	4	5
231	S:S:I62	S:S:M105	4.37	No	No	0	8	8
232	S:S:I62	S:S:P106	5.08	No	No	0	8	9
233	S:S:F64	S:S:S431	3.96	No	Yes	0	5	8
234	S:S:S431	S:S:T65	4.8	Yes	No	0	8	8
235	S:S:G68	S:S:P434	4.06	No	No	0	9	9
236	S:S:A94	S:S:N69	4.69	No	No	0	9	9
237	S:S:D97	S:S:N69	6.73	No	No	0	9	9
238	S:S:N69	S:S:P434	11.4	No	No	0	9	9
239	S:S:I451	S:S:L71	5.71	No	No	0	8	8
240	S:S:L452	S:S:L71	9.69	No	No	0	8	8
241	S:S:V72	S:S:Y437	5.05	No	Yes	0	9	9
242	S:S:V73	S:S:V91	4.81	No	No	0	7	8
243	S:S:I451	S:S:I74	5.89	No	No	0	8	6
244	S:S:N87	S:S:V76	4.43	Yes	No	0	9	9
245	S:S:V76	S:S:V91	4.81	No	No	0	9	8
246	S:S:L82	S:S:S79	6.01	No	No	0	9	7
247	S:S:R446	S:S:S79	7.91	No	No	0	5	7
248	S:S:S447	S:S:S79	6.52	No	No	0	8	7
249	S:S:A81	S:S:R376	5.53	No	No	6	7	7
250	S:S:A81	S:S:D443	6.18	No	Yes	6	7	8
251	S:S:L82	S:S:N87	4.12	No	Yes	0	9	9
252	S:S:F444	S:S:L82	12.18	Yes	No	0	9	9
253	S:S:P85	S:S:R163	7.21	No	Yes	0	7	8
254	S:S:P165	S:S:P85	7.79	No	No	0	6	7
255	S:S:D148	S:S:Q86	6.53	No	Yes	5	9	8
256	S:S:Q86	S:S:R149	11.68	Yes	Yes	5	8	9
257	S:S:Q86	S:S:R163	16.35	Yes	Yes	5	8	8
258	S:S:E377	S:S:Q86	11.47	Yes	Yes	5	8	8
259	S:S:F380	S:S:Q86	9.37	Yes	Yes	5	8	8
260	S:S:L90	S:S:N87	4.12	No	Yes	0	8	9
261	S:S:F380	S:S:N87	13.29	Yes	Yes	0	8	9
262	S:S:L88	S:S:V168	5.96	No	No	0	7	8
263	S:S:K169	S:S:L88	8.46	No	No	0	5	7
264	S:S:F89	S:S:I145	5.02	Yes	No	0	8	9
265	S:S:F89	S:S:V168	6.55	Yes	No	0	8	8
266	S:S:F89	S:S:T171	5.19	Yes	No	0	8	7
267	S:S:L384	S:S:L90	4.15	No	No	0	8	8
268	S:S:L90	S:S:Y437	11.72	No	Yes	0	8	9
269	S:S:H141	S:S:S92	9.76	Yes	No	10	8	9
270	S:S:I172	S:S:S92	9.29	No	No	0	9	9
271	S:S:S92	S:S:W176	6.18	No	Yes	10	9	9
272	S:S:H141	S:S:L93	7.71	Yes	No	0	8	9
273	S:S:D97	S:S:S430	10.31	No	No	0	9	9
274	S:S:L103	S:S:L99	4.15	No	No	0	6	8
275	S:S:F134	S:S:L99	12.18	Yes	No	0	7	8
276	S:S:F134	S:S:V100	3.93	Yes	No	0	7	9
277	S:S:S430	S:S:V100	4.85	No	No	0	9	9
278	S:S:D131	S:S:V104	4.38	No	No	0	9	9
279	S:S:M105	S:S:W424	4.65	No	Yes	2	8	8
280	S:S:M105	S:S:Y427	9.58	No	Yes	2	8	8
281	S:S:F107	S:S:W117	4.01	Yes	Yes	4	7	9
282	S:S:F107	S:S:F119	12.86	Yes	Yes	4	7	7
283	S:S:F107	S:S:W123	19.04	Yes	Yes	4	7	5
284	S:S:F107	S:S:Y127	5.16	Yes	Yes	4	7	5
285	S:S:S108	S:S:Y127	7.63	No	Yes	0	8	5
286	S:S:S108	S:S:Y427	8.9	No	Yes	0	8	8
287	S:S:L109	S:S:L113	8.3	No	Yes	0	8	7
288	S:S:N111	S:S:W117	10.17	No	Yes	0	6	9
289	S:S:E112	S:S:K420	13.5	No	No	0	6	5
290	S:S:M114	S:S:Y116	4.79	No	Yes	4	6	4
291	S:S:M114	S:S:Y118	5.99	No	No	4	6	5
292	S:S:Y116	S:S:Y118	4.96	Yes	No	4	4	5
293	S:S:P200	S:S:Y116	4.17	No	Yes	0	4	4
294	S:S:F119	S:S:W117	16.04	Yes	Yes	4	7	9
295	S:S:W117	S:S:W123	5.62	Yes	Yes	4	9	5
296	S:S:C124	S:S:W117	7.84	No	Yes	4	9	9
297	S:S:W117	S:S:Y127	11.58	Yes	Yes	4	9	5
298	S:S:C202	S:S:W117	14.37	No	Yes	4	9	9
299	S:S:W122	S:S:W123	5.62	No	Yes	4	5	5
300	S:S:V126	S:S:W122	8.58	No	No	4	6	5
301	S:S:V126	S:S:W123	7.36	No	Yes	4	6	5
302	S:S:C124	S:S:C202	7.28	No	No	4	9	9
303	S:S:L128	S:S:Y127	4.69	No	Yes	0	7	5
304	S:S:L128	S:S:L204	5.54	No	No	0	7	7
305	S:S:A129	S:S:F184	4.16	No	Yes	0	8	6
306	S:S:F134	S:S:L130	12.18	Yes	No	0	7	6
307	S:S:D131	S:S:Y427	5.75	No	Yes	0	9	8
308	S:S:V132	S:S:Y191	10.09	No	No	0	8	5
309	S:S:L133	S:S:S183	7.51	No	No	11	8	8
310	S:S:F184	S:S:L133	4.87	Yes	No	11	6	8
311	S:S:F134	S:S:W176	4.01	Yes	Yes	0	7	9
312	S:S:C135	S:S:W395	10.45	No	Yes	0	8	8
313	S:S:I182	S:S:T136	4.56	No	No	0	8	8
314	S:S:S183	S:S:T136	6.4	No	No	0	8	8
315	S:S:S218	S:S:T136	9.59	No	No	0	8	8
316	S:S:S137	S:S:W176	11.12	No	Yes	0	8	9
317	S:S:S138	S:S:W391	6.18	No	Yes	0	9	9
318	S:S:I178	S:S:V140	4.61	No	No	0	6	8
319	S:S:S179	S:S:V140	4.85	No	No	0	8	8
320	S:S:H141	S:S:V175	5.54	Yes	No	0	8	8
321	S:S:H141	S:S:W176	5.29	Yes	Yes	10	8	9
322	S:S:L142	S:S:M226	5.65	No	No	12	9	9
323	S:S:L142	S:S:M388	8.48	No	Yes	12	9	8
324	S:S:L142	S:S:W391	5.69	No	Yes	0	9	9
325	S:S:C143	S:S:I225	8.18	No	No	0	8	7
326	S:S:I145	S:S:L384	9.99	No	No	0	9	8
327	S:S:S146	S:S:V229	8.08	No	No	0	9	8
328	S:S:L147	S:S:W151	4.56	No	No	0	8	5
329	S:S:D148	S:S:S152	4.42	No	No	5	9	8
330	S:S:D148	S:S:R163	4.76	No	Yes	5	9	8
331	S:S:E377	S:S:R149	6.98	Yes	Yes	5	8	9
332	S:S:F380	S:S:R149	21.38	Yes	Yes	5	8	9
333	S:S:R149	S:S:T381	12.94	Yes	No	0	9	8
334	S:S:W151	S:S:Y150	7.72	No	No	0	5	9
335	S:S:T154	S:S:Y150	9.99	No	No	0	8	9
336	S:S:R232	S:S:Y150	14.4	No	No	0	7	9
337	S:S:R163	S:S:S152	5.27	Yes	No	5	8	8
338	S:S:E377	S:S:S152	5.75	Yes	No	5	8	8
339	S:S:V153	S:S:V236	4.81	No	No	0	8	7
340	S:S:E158	S:S:Q155	12.74	No	No	13	6	7
341	S:S:Q155	S:S:Y159	14.65	No	No	13	7	9
342	S:S:E158	S:S:Y159	10.1	No	No	13	6	9
343	S:S:N160	S:S:R163	4.82	No	Yes	0	7	8
344	S:S:K162	S:S:R167	11.14	No	No	0	5	7
345	S:S:E377	S:S:R163	5.82	Yes	Yes	5	8	8
346	S:S:F184	S:S:S183	5.28	Yes	No	11	6	8
347	S:S:F184	S:S:Y191	7.22	Yes	No	0	6	5
348	S:S:P185	S:S:S189	7.13	No	No	0	9	6
349	S:S:D206	S:S:R192	9.53	No	No	0	5	5
350	S:S:L204	S:S:Y210	8.21	No	Yes	0	7	7
351	S:S:E207	S:S:N205	6.57	No	No	0	6	7
352	S:S:N205	S:S:Y210	10.47	No	Yes	0	7	7
353	S:S:D206	S:S:Y405	5.75	No	No	0	5	4
354	S:S:S214	S:S:Y210	11.45	No	Yes	0	8	7
355	S:S:Y210	S:S:Y402	3.97	Yes	Yes	0	7	8
356	S:S:I211	S:S:Y402	15.71	No	Yes	0	7	8
357	S:S:G406	S:S:I211	5.29	No	No	0	7	7
358	S:S:I407	S:S:L212	4.28	No	No	0	5	7
359	S:S:C215	S:S:F399	4.19	No	Yes	0	8	8
360	S:S:C215	S:S:Y402	5.38	No	Yes	0	8	8
361	S:S:C215	S:S:S403	5.16	No	No	0	8	7
362	S:S:F219	S:S:F220	9.65	Yes	No	0	8	7
363	S:S:C223	S:S:F219	8.38	No	Yes	0	7	8
364	S:S:F219	S:S:W391	5.01	Yes	Yes	0	8	9
365	S:S:F219	S:S:F396	4.29	Yes	No	0	8	7
366	S:S:F219	S:S:F399	21.43	Yes	Yes	0	8	8
367	S:S:F220	S:S:S403	6.61	No	No	0	7	7
368	S:S:C223	S:S:V392	5.12	No	No	0	7	8
369	S:S:L224	S:S:L228	8.3	No	No	0	5	5
370	S:S:M226	S:S:M388	5.78	No	Yes	12	9	8
371	S:S:I233	S:S:Y230	10.88	No	Yes	0	9	9
372	S:S:T381	S:S:Y230	4.99	No	Yes	0	8	9
373	S:S:A385	S:S:Y230	4	No	Yes	0	8	9
374	S:S:M388	S:S:Y230	7.18	Yes	Yes	0	8	9
375	S:S:L239	S:S:T241	4.42	No	No	0	5	5
376	S:S:R376	S:S:R379	5.33	No	Yes	6	7	8
377	S:S:D443	S:S:R376	10.72	Yes	No	6	8	7
378	S:S:Q442	S:S:R379	16.35	No	Yes	0	5	8
379	S:S:D443	S:S:R379	5.96	Yes	Yes	6	8	8
380	S:S:F380	S:S:L384	4.87	Yes	No	0	8	8
381	S:S:F382	S:S:V386	3.93	No	No	0	7	8
382	S:S:F382	S:S:F440	6.43	No	No	0	7	8
383	S:S:F440	S:S:V383	3.93	No	No	0	8	9
384	S:S:N441	S:S:V383	5.91	No	No	0	9	9
385	S:S:I436	S:S:V386	4.61	No	No	0	9	8
386	S:S:N433	S:S:V387	4.43	No	No	0	9	9
387	S:S:I436	S:S:V387	4.61	No	No	0	9	9
388	S:S:I436	S:S:V390	4.61	No	No	0	9	7
389	S:S:W391	S:S:W395	12.18	Yes	Yes	0	9	8
390	S:S:N429	S:S:W391	7.91	No	Yes	0	9	9
391	S:S:C394	S:S:N429	9.45	No	No	0	9	9
392	S:S:F399	S:S:W395	9.02	Yes	Yes	0	8	8
393	S:S:G426	S:S:W395	11.26	No	Yes	0	8	8
394	S:S:F396	S:S:P397	4.33	No	No	0	7	9
395	S:S:F396	S:S:F400	10.72	No	No	0	7	7
396	S:S:F422	S:S:P397	10.11	Yes	No	0	6	9
397	S:S:F398	S:S:F399	13.93	Yes	Yes	2	8	8
398	S:S:F398	S:S:Y402	7.22	Yes	Yes	2	8	8
399	S:S:F398	S:S:F419	7.5	Yes	Yes	2	8	5
400	S:S:F398	S:S:F423	8.57	Yes	Yes	2	8	6
401	S:S:F400	S:S:L404	8.53	No	No	0	7	6
402	S:S:S401	S:S:V414	8.08	No	No	2	6	6
403	S:S:F419	S:S:S401	3.96	Yes	No	2	5	6
404	S:S:F422	S:S:S401	3.96	Yes	No	2	6	6
405	S:S:F419	S:S:Y402	4.13	Yes	Yes	2	5	8
406	S:S:C412	S:S:L404	4.76	No	No	0	7	6
407	S:S:R409	S:S:Y405	14.4	No	No	0	5	4
408	S:S:Q413	S:S:Y405	4.51	No	No	0	2	4
409	S:S:C408	S:S:C412	7.28	No	No	0	7	7
410	S:S:F419	S:S:V414	3.93	Yes	No	2	5	6
411	S:S:G416	S:S:P417	4.06	No	No	0	2	3
412	S:S:F422	S:S:L418	13.4	Yes	No	2	6	5
413	S:S:F419	S:S:F423	4.29	Yes	Yes	2	5	6
414	S:S:F421	S:S:I425	7.54	Yes	No	0	6	8
415	S:S:F423	S:S:W424	4.01	Yes	Yes	2	6	8
416	S:S:W424	S:S:Y427	12.54	Yes	Yes	2	8	8
417	S:S:N433	S:S:Y437	6.98	No	Yes	0	9	9
418	S:S:F444	S:S:Y437	16.5	Yes	Yes	0	9	9
419	S:S:F448	S:S:T438	6.49	No	No	0	8	9
420	S:S:F440	S:S:V439	11.8	No	No	0	8	7
421	S:S:D443	S:S:N441	8.08	Yes	No	0	8	9
422	S:S:F444	S:S:N441	8.46	Yes	No	0	9	9
423	S:S:F444	S:S:F448	7.5	Yes	No	0	9	8
424	S:S:K449	S:S:R445	4.95	No	No	0	5	9
425	R:R:A139	R:R:W391	3.89	No	Yes	0	9	9
426	S:S:A139	S:S:W391	3.89	No	Yes	0	9	9
427	R:R:F89	R:R:I172	3.77	Yes	No	0	8	9
428	R:R:I211	R:R:R409	3.76	No	Yes	0	7	5
429	S:S:I211	S:S:R409	3.76	No	No	0	7	5
430	R:R:A129	R:R:P185	3.74	No	No	0	8	9
431	R:R:A139	R:R:P222	3.74	No	No	0	9	9
432	S:S:A139	S:S:P222	3.74	No	No	0	9	9
433	R:R:K449	R:R:R445	3.71	No	No	0	5	9
434	R:R:F448	R:R:L71	3.65	No	No	0	8	8
435	S:S:T208	S:S:W209	3.64	No	No	0	5	5
436	R:R:P185	R:R:S183	3.56	No	No	0	9	8
437	R:R:P434	R:R:V72	3.53	No	No	0	9	9
438	R:R:P415	R:R:V414	3.53	No	No	0	7	6
439	S:S:P434	S:S:V72	3.53	No	No	0	9	9
440	S:S:P415	S:S:V414	3.53	No	No	0	7	6
441	R:R:L54	R:R:Y46	3.52	No	Yes	0	5	6
442	R:R:P165	R:R:T164	3.5	No	No	0	6	8
443	R:R:Q442	R:R:R445	3.5	No	No	0	5	9
444	S:S:P165	S:S:T164	3.5	No	No	0	6	8
445	R:R:E410	R:R:R409	3.49	No	Yes	0	4	5
446	S:S:E410	S:S:R409	3.49	No	No	0	4	5
447	R:R:A75	R:R:S447	3.42	No	No	0	9	8
448	R:R:L133	R:R:W176	3.42	No	Yes	0	8	9
449	S:S:G68	S:S:L71	3.42	No	No	0	9	8
450	S:S:A75	S:S:S447	3.42	No	No	0	9	8
451	S:S:L212	S:S:W209	3.42	No	No	0	7	5
452	R:R:A101	R:R:T65	3.36	No	No	0	8	8
453	S:S:A101	S:S:T65	3.36	No	No	0	8	8
454	R:R:C408	R:R:I407	3.27	No	No	0	7	5
455	S:S:C408	S:S:I407	3.27	No	No	0	7	5
456	S:S:S137	S:S:S179	3.26	No	No	0	8	8
457	S:S:A101	S:S:I62	3.25	No	No	0	8	8
458	R:R:S430	R:R:V100	3.23	No	No	0	9	9
459	R:R:V73	R:R:V91	3.21	No	No	0	7	8
460	R:R:V153	R:R:V236	3.21	No	No	0	8	7
461	R:R:S430	R:R:T65	3.2	No	No	0	9	8
462	R:R:R376	R:R:R379	3.2	No	No	0	7	8
463	S:S:R80	S:S:R83	3.2	No	No	0	8	8
464	R:R:C428	R:R:L61	3.17	No	No	0	6	7
465	R:R:I182	R:R:S218	3.1	No	No	0	8	8
466	R:R:I74	R:R:V70	3.07	No	No	0	6	6
467	R:R:I98	R:R:V70	3.07	No	No	0	8	6
468	R:R:M388	R:R:S146	3.07	No	No	0	8	9
469	R:R:I233	R:R:V229	3.07	No	No	0	9	8
470	S:S:I98	S:S:V70	3.07	No	No	0	8	6
471	S:S:M388	S:S:S146	3.07	Yes	No	0	8	9
472	S:S:I98	S:S:T102	3.04	No	No	0	8	6
473	S:S:A84	S:S:Q86	3.03	No	Yes	0	8	8
474	R:R:L432	R:R:S431	3	No	No	0	7	8
475	S:S:L61	S:S:S431	3	No	Yes	0	7	8
476	S:S:L147	S:S:S146	3	No	No	0	8	9
477	S:S:G203	S:S:R192	3	No	No	0	3	5
478	S:S:L432	S:S:S431	3	No	Yes	0	7	8
479	R:R:L113	R:R:V51	2.98	No	No	0	7	5
480	R:R:L77	R:R:V73	2.98	No	No	0	5	7
481	R:R:L90	R:R:V76	2.98	No	No	0	8	9
482	R:R:L177	R:R:V173	2.98	No	No	0	5	6
483	R:R:L204	R:R:V188	2.98	Yes	No	0	7	5
484	S:S:L77	S:S:V91	2.98	No	No	0	5	8
485	S:S:Y230	S:S:Y234	2.98	Yes	No	0	9	6
486	S:S:L239	S:S:V236	2.98	No	No	0	5	7
487	S:S:L103	S:S:T102	2.95	No	No	0	6	6
488	R:R:E158	R:R:V157	2.85	No	No	0	6	7
489	R:R:Q155	R:R:T154	2.83	No	No	0	7	8
490	R:R:G120	R:R:W117	2.81	No	Yes	0	8	9
491	S:S:G120	S:S:W117	2.81	No	Yes	0	8	9
492	R:R:P41	R:R:Y199	2.78	No	Yes	0	3	3
493	R:R:A144	R:R:F89	2.77	No	Yes	0	8	8
494	R:R:L103	R:R:L99	2.77	No	No	0	6	8
495	R:R:L103	R:R:L130	2.77	No	No	0	6	6
496	R:R:A110	R:R:F119	2.77	No	Yes	0	7	7
497	R:R:L224	R:R:L228	2.77	No	No	0	5	5
498	S:S:L113	S:S:L54	2.77	Yes	No	0	7	5
499	S:S:A144	S:S:F89	2.77	No	Yes	0	8	8
500	S:S:A110	S:S:F119	2.77	No	Yes	0	7	7
501	S:S:A180	S:S:F184	2.77	No	Yes	0	7	6
502	R:R:A50	R:R:Y46	2.67	No	Yes	0	5	6
503	S:S:A50	S:S:Y46	2.67	No	Yes	0	5	6
504	R:R:F64	R:R:V435	2.62	No	No	0	5	6
505	R:R:R240	R:R:V236	2.62	No	No	0	8	7
506	S:S:F64	S:S:V435	2.62	No	No	0	5	6
507	R:R:A96	R:R:W176	2.59	No	Yes	0	9	9
508	S:S:A96	S:S:W176	2.59	No	Yes	0	9	9
509	S:S:R167	S:S:T164	2.59	No	No	0	7	8
510	R:R:Q201	R:R:Y116	2.25	No	Yes	0	4	4
511	S:S:Q201	S:S:Y116	2.25	No	Yes	0	4	4
512	R:R:F60	R:R:F64	2.14	No	No	0	4	5
513	S:S:F119	S:S:Y118	2.06	Yes	No	4	7	5
514	R:R:A115	R:R:G44	1.95	No	No	0	6	5
515	R:R:A52	R:R:G53	1.95	No	No	0	6	4
516	R:R:A56	R:R:G53	1.95	No	No	0	5	4
517	S:S:A115	S:S:G44	1.95	No	No	0	6	5
518	S:S:A52	S:S:G53	1.95	No	No	0	6	4
519	S:S:A56	S:S:G53	1.95	No	No	0	5	4
520	S:S:P185	S:S:P186	1.95	No	No	0	9	8
521	R:R:C143	R:R:P222	1.88	No	No	0	8	9
522	S:S:C143	S:S:P222	1.88	No	No	0	8	9
523	R:R:A84	R:R:P85	1.87	No	No	0	8	7
524	R:R:A197	R:R:P200	1.87	No	No	0	4	4
525	R:R:A221	R:R:P222	1.87	No	No	0	7	9
526	S:S:A221	S:S:P222	1.87	No	No	0	7	9
527	S:S:G49	S:S:S47	1.86	No	No	0	4	6
528	R:R:G68	R:R:V67	1.84	No	No	0	9	6
529	S:S:G68	S:S:V67	1.84	No	No	0	9	6
530	R:R:A411	R:R:C408	1.81	No	No	0	3	7
531	S:S:A411	S:S:C408	1.81	No	No	0	3	7
532	S:S:P186	S:S:V181	1.77	No	No	0	8	5
533	R:R:G217	R:R:I182	1.76	No	No	0	6	8
534	R:R:G217	R:R:I216	1.76	No	No	0	6	5
535	S:S:G217	S:S:I182	1.76	No	No	0	6	8
536	R:R:G227	R:R:M226	1.75	No	No	0	6	9
537	S:S:G227	S:S:M226	1.75	No	No	0	6	9
538	S:S:G389	S:S:M388	1.75	No	Yes	0	7	8
539	R:R:C124	R:R:S189	1.72	No	No	0	9	6
540	R:R:A50	R:R:S47	1.71	No	No	0	5	6
541	R:R:G203	R:R:L128	1.71	No	Yes	0	3	7
542	R:R:A411	S:S:S47	1.71	No	No	0	3	6
543	S:S:A50	S:S:S47	1.71	No	No	0	5	6
544	R:R:A101	R:R:V66	1.7	No	No	0	8	7
545	S:S:A101	S:S:V66	1.7	No	No	0	8	7
546	R:R:K169	R:R:P165	1.67	No	No	0	5	6
547	S:S:A221	S:S:I216	1.62	No	No	0	7	5
548	R:R:A110	R:R:M114	1.61	No	No	0	7	6
549	R:R:A237	R:R:K378	1.61	No	No	0	8	7
550	R:R:V57	R:R:V58	1.6	No	No	0	6	7
551	R:R:V63	R:R:V67	1.6	No	No	0	5	6
552	R:R:S447	R:R:T78	1.6	No	No	0	8	7
553	S:S:V63	S:S:V67	1.6	No	No	0	5	6
554	R:R:T154	R:R:V236	1.59	No	No	0	8	7
555	S:S:C428	S:S:L61	1.59	No	No	0	6	7
556	R:R:A55	R:R:L109	1.58	No	No	0	6	8
557	R:R:A180	R:R:L133	1.58	No	No	0	7	8
558	S:S:A55	S:S:L109	1.58	No	No	0	6	8
559	S:S:I74	S:S:T78	1.52	No	No	0	6	7
560	S:S:A373	S:S:Q374	1.52	No	No	0	5	5
561	R:R:L190	R:R:S189	1.5	No	No	0	5	6
562	S:S:L54	S:S:V57	1.49	No	No	0	5	6
563	S:S:L161	S:S:V157	1.49	No	No	0	6	7
564	S:S:F184	S:S:P185	1.44	Yes	No	0	6	9
565	R:R:P200	R:R:Y199	1.39	No	Yes	0	4	3
566	S:S:P42	S:S:Y116	1.39	No	Yes	0	4	4
567	R:R:A375	R:R:R379	1.38	No	No	0	6	8
568	S:S:A375	S:S:R379	1.38	No	Yes	0	6	8
569	R:R:E158	R:R:K162	1.35	No	No	0	6	5
570	R:R:A237	R:R:Y234	1.33	No	No	0	8	6
571	S:S:A237	S:S:Y234	1.33	No	No	0	8	6
572	S:S:R43	S:S:V51	1.31	No	No	0	1	5
573	R:R:R166	R:R:T164	1.29	No	No	0	7	8
574	S:S:R445	S:S:T438	1.29	No	No	0	9	9
575	R:R:S213	R:R:W209	1.24	No	No	0	7	5
576	S:S:L77	S:S:R83	1.21	No	No	0	5	8
577	S:S:K162	S:S:Y159	1.19	No	No	0	5	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.745	12	1	0
2	M:M:?1	9.72	11	2	0
3	R:R:Y46	6.252	5	0	6
4	R:R:F89	4.68	6	0	8
5	R:R:M105	6.41	4	1	8
6	R:R:F107	10.24	4	1	7
7	R:R:Y116	8.605	4	7	4
8	R:R:W117	8.78	8	1	9
9	R:R:F119	7.734	5	1	7
10	R:R:W123	8.72	5	1	5
11	R:R:Y127	6.31833	6	1	5
12	R:R:L128	3.8275	4	0	7
13	R:R:H141	6.7525	4	8	8
14	R:R:D148	8.075	4	3	9
15	R:R:R149	7.1	5	3	9
16	R:R:Y150	7.6875	4	0	9
17	R:R:R163	11.02	6	3	8
18	R:R:W176	5.435	6	8	9
19	R:R:Y199	9.6825	4	7	3
20	R:R:L204	4.9225	4	0	7
21	R:R:Y210	7.994	5	0	7
22	R:R:F219	10.196	5	0	8
23	R:R:Y230	7.64	4	0	9
24	R:R:F380	6.0125	4	3	8
25	R:R:W391	7.27667	6	0	9
26	R:R:W395	9.18	4	0	8
27	R:R:F398	10.79	5	1	8
28	R:R:F399	10.63	5	1	8
29	R:R:Y402	8.08	6	1	8
30	R:R:R409	6.26	4	0	5
31	R:R:F421	7.535	4	2	6
32	R:R:F422	6.6475	4	2	6
33	R:R:F423	8.58	4	1	6
34	R:R:W424	7.3075	4	1	8
35	R:R:Y427	8.188	5	1	8
36	R:R:Y437	8.302	5	3	9
37	R:R:F440	5.005	4	9	8
38	R:R:D443	6.892	5	0	8
39	R:R:F444	10.2	5	3	9
40	S:S:Y46	7.195	4	0	6
41	S:S:Q86	9.73833	6	5	8
42	S:S:N87	6.49	4	0	9
43	S:S:F89	4.8825	4	0	8
44	S:S:F107	10.2675	4	4	7
45	S:S:L113	6.095	4	0	7
46	S:S:Y116	3.512	5	4	4
47	S:S:W117	9.055	8	4	9
48	S:S:F119	8.4325	4	4	7
49	S:S:W123	9.41	4	4	5
50	S:S:Y127	7.265	4	4	5
51	S:S:F134	8.075	4	0	7
52	S:S:H141	7.075	4	10	8
53	S:S:R149	13.245	4	5	9
54	S:S:R163	7.37167	6	5	8
55	S:S:W176	5.838	5	10	9
56	S:S:F184	4.29	6	11	6
57	S:S:Y210	8.525	4	0	7
58	S:S:F219	9.752	5	0	8
59	S:S:Y230	6.006	5	0	9
60	S:S:E377	7.505	4	5	8
61	S:S:R379	7.255	4	6	8
62	S:S:F380	12.2275	4	5	8
63	S:S:M388	5.252	5	12	8
64	S:S:W391	6.81	6	0	9
65	S:S:W395	10.7275	4	0	8
66	S:S:F398	10.646	5	2	8
67	S:S:F399	11.398	5	2	8
68	S:S:Y402	6.88	6	2	8
69	S:S:F419	4.67	6	2	5
70	S:S:F421	6.6975	4	2	6
71	S:S:F422	9.01	4	2	6
72	S:S:F423	8.0075	4	2	6
73	S:S:W424	7.445	4	2	8
74	S:S:Y427	9.1925	4	2	8
75	S:S:S431	3.69	4	0	8
76	S:S:Y437	10.0625	4	0	9
77	S:S:D443	7.735	4	6	8
78	S:S:F444	11.16	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F398	12.3476	12.64	Yes	Yes	1	0	8
2	R:R:F398	R:R:F419	69.7159	8.57	Yes	No	1	8	5
3	R:R:F419	R:R:V414	85.8473	3.93	No	No	0	5	6
4	R:R:P415	R:R:V414	30.2412	3.53	No	No	0	7	6
5	R:R:P415	S:S:P417	30.5115	7.79	No	No	0	7	3
6	R:R:P417	S:S:P417	31.0778	11.69	No	No	0	3	3
7	R:R:P417	S:S:P415	31.6395	7.79	No	No	0	3	7
8	S:S:P415	S:S:V414	31.9269	3.53	No	No	0	7	6
9	S:S:F419	S:S:V414	31.8629	3.93	Yes	No	2	5	6
10	M:M:?1	S:S:F419	20.501	4.21	Yes	Yes	2	0	5
11	L:L:?1	R:R:Y402	17.2023	8.11	Yes	Yes	1	0	8
12	R:R:F419	R:R:Y402	16.2394	4.13	No	Yes	1	5	8
13	M:M:?1	S:S:C135	14.1989	6.59	Yes	No	0	0	8
14	M:M:?1	S:S:L204	21.4318	5.74	Yes	No	0	0	7
15	M:M:?1	S:S:F399	28.4522	8.42	Yes	Yes	2	0	8
16	S:S:F398	S:S:F399	13.363	13.93	Yes	Yes	2	8	8
17	L:L:?1	R:R:Y127	27.9688	4.05	Yes	Yes	1	0	5
18	R:R:F107	R:R:Y127	10.2539	6.19	Yes	Yes	1	7	5
19	R:R:F119	R:R:Y118	11.0345	4.13	Yes	No	0	7	5
20	R:R:W117	R:R:Y127	14.2927	11.58	Yes	Yes	1	9	5
21	L:L:?1	R:R:C135	10.7242	6.59	Yes	No	0	0	8
22	R:R:C135	R:R:W395	10.4048	9.14	No	Yes	0	8	8
23	R:R:W391	R:R:W395	50.6211	10.31	Yes	Yes	0	9	8
24	R:R:L142	R:R:W391	88.321	7.97	No	Yes	0	9	9
25	R:R:L142	R:R:M388	86.6479	9.9	No	No	0	9	8
26	R:R:M388	R:R:Y230	84.8154	8.38	No	Yes	0	8	9
27	R:R:I233	R:R:Y230	81.9926	10.88	No	Yes	0	9	9
28	R:R:I233	R:R:Y150	81.5669	4.84	No	Yes	0	9	9
29	R:R:W151	R:R:Y150	76.9728	4.82	No	Yes	0	5	9
30	R:R:W151	R:R:Y159	75.8128	12.54	No	No	0	5	9
31	R:R:R163	R:R:Y159	50.5863	10.29	Yes	No	3	8	9
32	R:R:R149	R:R:R163	42.0997	4.26	Yes	Yes	3	9	8
33	R:R:F380	R:R:R149	39.5295	6.41	Yes	Yes	3	8	9
34	R:R:F380	R:R:F444	33.0663	4.29	Yes	Yes	3	8	9
35	R:R:F444	R:R:Y437	23.6043	18.57	Yes	Yes	3	9	9
36	R:R:V72	R:R:Y437	12.6607	5.05	No	Yes	0	9	9
37	R:R:P434	R:R:V72	11.967	3.53	No	No	0	9	9
38	L:L:?1	R:R:F399	22.4992	7.58	Yes	Yes	1	0	8
39	R:R:F399	R:R:W395	40.7643	6.01	Yes	Yes	0	8	8
40	R:R:F219	R:R:F399	44.1876	22.51	Yes	Yes	0	8	8
41	R:R:F219	R:R:W391	42.7562	4.01	Yes	Yes	0	8	9
42	R:R:D148	R:R:Y159	24.6443	9.2	Yes	No	3	9	9
43	R:R:A84	R:R:Q86	13.5133	4.55	No	No	0	8	8
44	R:R:A84	R:R:P85	12.167	1.87	No	No	0	8	7
45	R:R:P165	R:R:P85	10.8196	7.79	No	No	0	6	7
46	R:R:D148	R:R:F89	17.128	4.78	Yes	Yes	0	9	8
47	R:R:F89	R:R:I172	13.9761	3.77	Yes	No	0	8	9
48	R:R:I172	R:R:S92	13.2881	7.74	No	No	0	9	9
49	R:R:S401	R:R:V414	55.5598	9.7	No	No	0	6	6
50	R:R:F422	R:R:S401	55.4495	3.96	Yes	No	0	6	6
51	R:R:F422	S:S:F421	54.941	6.43	Yes	Yes	2	6	6
52	R:R:F421	S:S:F421	54.9073	4.29	Yes	Yes	2	6	6
53	R:R:F421	S:S:F422	54.4056	8.57	Yes	Yes	2	6	6
54	S:S:L128	S:S:L204	20.0627	5.54	No	No	0	7	7
55	S:S:L128	S:S:Y127	19.4605	4.69	No	Yes	0	7	5
56	S:S:W117	S:S:Y127	11.0956	11.58	Yes	Yes	4	9	5
57	S:S:F423	S:S:W424	25.7883	4.01	Yes	Yes	2	6	8
58	S:S:V58	S:S:W424	14.0647	8.58	No	Yes	0	7	8
59	S:S:L109	S:S:V58	13.4635	10.43	No	No	0	8	7
60	S:S:L109	S:S:L113	12.3504	8.3	No	Yes	0	8	7
61	S:S:M105	S:S:W424	11.179	4.65	No	Yes	2	8	8
62	S:S:I62	S:S:M105	14.5155	4.37	No	No	0	8	8
63	S:S:A101	S:S:I62	12.1076	3.25	No	No	0	8	8
64	S:S:F422	S:S:P397	53.7256	10.11	Yes	No	0	6	9
65	S:S:F396	S:S:P397	53.5124	4.33	No	No	0	7	9
66	S:S:F219	S:S:F396	52.7125	4.29	Yes	No	0	8	7
67	S:S:F219	S:S:W391	71.3656	5.01	Yes	Yes	0	8	9
68	S:S:L142	S:S:W391	100	5.69	No	Yes	0	9	9
69	S:S:L142	S:S:M388	98.2269	8.48	No	Yes	12	9	8
70	S:S:M388	S:S:Y230	93.5682	7.18	Yes	Yes	0	8	9
71	S:S:T381	S:S:Y230	90.8397	4.99	No	Yes	0	8	9
72	S:S:R149	S:S:T381	90.2906	12.94	Yes	No	0	9	8
73	S:S:F380	S:S:R149	74.0746	21.38	Yes	Yes	5	8	9
74	S:S:F380	S:S:N87	43.8059	13.29	Yes	Yes	0	8	9
75	S:S:L90	S:S:N87	25.9534	4.12	No	Yes	0	8	9
76	S:S:L90	S:S:Y437	50.6291	11.72	No	Yes	0	8	9
77	S:S:V72	S:S:Y437	43.2939	5.05	No	Yes	0	9	9
78	S:S:P434	S:S:V72	42.0003	3.53	No	No	0	9	9
79	S:S:G68	S:S:P434	10.6094	4.06	No	No	0	9	9
80	S:S:F380	S:S:L384	30.9378	4.87	Yes	No	0	8	8
81	S:S:L384	S:S:L90	26.0511	4.15	No	No	0	8	8
82	S:S:N69	S:S:P434	30.3058	11.4	No	No	0	9	9
83	S:S:D97	S:S:N69	27.6945	6.73	No	No	0	9	9
84	S:S:L82	S:S:N87	13.6435	4.12	No	Yes	0	9	9
85	S:S:F444	S:S:L82	10.5179	12.18	Yes	No	0	9	9
86	S:S:P85	S:S:R163	10.6779	7.21	No	Yes	0	7	8
87	S:S:D97	S:S:S430	26.3871	10.31	No	No	0	9	9
88	S:S:S430	S:S:V100	25.0786	4.85	No	No	0	9	9
89	S:S:F134	S:S:V100	23.7689	3.93	Yes	No	0	7	9
90	S:S:F134	S:S:W176	14.5692	4.01	Yes	Yes	0	7	9
91	S:S:C135	S:S:W395	13.9395	10.45	No	Yes	0	8	8
92	S:S:F399	S:S:W395	21.9507	9.02	Yes	Yes	0	8	8
93	S:S:I211	S:S:Y402	10.2077	15.71	No	Yes	0	7	8
94	R:R:F398	R:R:F399	59.5197	12.86	Yes	Yes	1	8	8
95	M:M:?1	S:S:F423	12.527	15.16	Yes	Yes	2	0	6
96	S:S:W391	S:S:W395	33.9423	12.18	Yes	Yes	0	9	8
97	S:S:F219	S:S:F399	22.1541	21.43	Yes	Yes	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
M:M:?1	S:S:D131	26.28	2	Yes	No	0	9	0	1
M:M:?1	S:S:V132	11.34	2	Yes	No	0	8	0	1
M:M:?1	S:S:C135	6.59	2	Yes	No	0	8	0	1
M:M:?1	S:S:L204	5.74	2	Yes	No	0	7	0	1
M:M:?1	S:S:S214	4.15	2	Yes	No	0	8	0	1
M:M:?1	S:S:S218	4.15	2	Yes	No	0	8	0	1
M:M:?1	S:S:F398	16.01	2	Yes	Yes	0	8	0	1
M:M:?1	S:S:F399	8.42	2	Yes	Yes	0	8	0	1
M:M:?1	S:S:Y402	4.87	2	Yes	Yes	0	8	0	1
M:M:?1	S:S:F419	4.21	2	Yes	Yes	0	5	0	1
M:M:?1	S:S:F423	15.16	2	Yes	Yes	0	6	0	1
S:S:D131	S:S:V104	4.38	0	No	No	9	9	1	2
S:S:L128	S:S:L204	5.54	0	No	No	7	7	2	1
S:S:D131	S:S:Y427	5.75	0	No	Yes	9	8	1	2
S:S:V132	S:S:Y191	10.09	0	No	No	8	5	1	2
S:S:C135	S:S:W395	10.45	0	No	Yes	8	8	1	2
S:S:S218	S:S:T136	9.59	0	No	No	8	8	1	2
S:S:L204	S:S:Y210	8.21	0	No	Yes	7	7	1	2
S:S:S214	S:S:Y210	11.45	0	No	Yes	8	7	1	2
S:S:Y210	S:S:Y402	3.97	0	Yes	Yes	7	8	2	1
S:S:I211	S:S:Y402	15.71	0	No	Yes	7	8	2	1
S:S:C215	S:S:F399	4.19	0	No	Yes	8	8	2	1
S:S:C215	S:S:Y402	5.38	0	No	Yes	8	8	2	1
S:S:F219	S:S:F399	21.43	0	Yes	Yes	8	8	2	1
S:S:F399	S:S:W395	9.02	2	Yes	Yes	8	8	1	2
S:S:F398	S:S:F399	13.93	2	Yes	Yes	8	8	1	1
S:S:F398	S:S:Y402	7.22	2	Yes	Yes	8	8	1	1
S:S:F398	S:S:F419	7.5	2	Yes	Yes	8	5	1	1
S:S:F398	S:S:F423	8.57	2	Yes	Yes	8	6	1	1
S:S:S401	S:S:V414	8.08	2	No	No	6	6	2	2
S:S:F419	S:S:S401	3.96	2	Yes	No	5	6	1	2
S:S:F419	S:S:Y402	4.13	2	Yes	Yes	5	8	1	1
S:S:F419	S:S:V414	3.93	2	Yes	No	5	6	1	2
S:S:F419	S:S:F423	4.29	2	Yes	Yes	5	6	1	1
S:S:F423	S:S:W424	4.01	2	Yes	Yes	6	8	1	2
S:S:W424	S:S:Y427	12.54	2	Yes	Yes	8	8	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y127	4.05	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:D131	29.1	1	Yes	No	0	9	0	1
L:L:?1	R:R:V132	11.34	1	Yes	No	0	8	0	1
L:L:?1	R:R:C135	6.59	1	Yes	No	0	8	0	1
L:L:?1	R:R:L204	6.7	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:S214	4.15	1	Yes	No	0	8	0	1
L:L:?1	R:R:S218	4.15	1	Yes	No	0	8	0	1
L:L:?1	R:R:F398	12.64	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F399	7.58	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y402	8.11	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F423	16.85	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y427	5.68	1	Yes	Yes	0	8	0	1
R:R:V104	R:R:Y127	6.31	0	No	Yes	9	5	2	1
R:R:D131	R:R:V104	5.84	1	No	No	9	9	1	2
R:R:M105	R:R:W424	5.82	1	Yes	Yes	8	8	2	2
R:R:M105	R:R:Y427	8.38	1	Yes	Yes	8	8	2	1
R:R:F107	R:R:W117	4.01	1	Yes	Yes	7	9	2	2
R:R:F107	R:R:Y127	6.19	1	Yes	Yes	7	5	2	1
R:R:S108	R:R:Y127	5.09	0	No	Yes	8	5	2	1
R:R:S108	R:R:Y427	7.63	0	No	Yes	8	8	2	1
R:R:W117	R:R:Y127	11.58	1	Yes	Yes	9	5	2	1
R:R:L128	R:R:Y127	4.69	0	Yes	Yes	7	5	2	1
R:R:L128	R:R:L204	4.15	0	Yes	Yes	7	7	2	1
R:R:D131	R:R:Y427	5.75	1	No	Yes	9	8	1	1
R:R:S183	R:R:V132	4.85	0	No	No	8	8	2	1
R:R:C135	R:R:W395	9.14	0	No	Yes	8	8	1	2
R:R:S183	R:R:T136	6.4	0	No	No	8	8	2	2
R:R:S218	R:R:T136	9.59	0	No	No	8	8	1	2
R:R:L204	R:R:Y210	5.86	0	Yes	Yes	7	7	1	2
R:R:S214	R:R:Y210	12.72	0	No	Yes	8	7	1	2
R:R:Y210	R:R:Y402	3.97	0	Yes	Yes	7	8	2	1
R:R:I211	R:R:Y402	14.51	0	No	Yes	7	8	2	1
R:R:C215	R:R:F399	4.19	0	No	Yes	8	8	2	1
R:R:C215	R:R:Y402	5.38	0	No	Yes	8	8	2	1
R:R:F219	R:R:F399	22.51	0	Yes	Yes	8	8	2	1
R:R:F399	R:R:W395	6.01	1	Yes	Yes	8	8	1	2
R:R:F398	R:R:F399	12.86	1	Yes	Yes	8	8	1	1
R:R:F398	R:R:Y402	12.38	1	Yes	Yes	8	8	1	1
R:R:F398	R:R:F419	8.57	1	Yes	No	8	5	1	2
R:R:F398	R:R:F423	7.5	1	Yes	Yes	8	6	1	1
R:R:F419	R:R:Y402	4.13	1	No	Yes	5	8	2	1
R:R:F423	R:R:K420	4.96	1	Yes	No	6	5	1	2
R:R:F423	R:R:W424	5.01	1	Yes	Yes	6	8	1	2
R:R:W424	R:R:Y427	13.5	1	Yes	Yes	8	8	2	1
R:R:I182	R:R:S218	3.1	0	No	No	8	8	2	1
R:R:L204	R:R:V188	2.98	0	Yes	No	7	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6KUW_poly
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.93
Number of Linked Nodes	507
Number of Links	577
Number of Hubs	78
Number of Links mediated by Hubs	298
Number of Communities	13
Number of Nodes involved in Communities	92
Number of Links involved in Communities	128

Path Summary
Number Of Nodes in MetaPath	98
Number Of Links MetaPath	97
Number of Shortest Paths	372281
Length Of Smallest Path	3
Average Path Length	22.4949
Length of Longest Path	57
Minimum Path Strength	1.47
Average Path Strength	7.72516
Maximum Path Strength	22.975
Minimum Path Correlation	0.7
Average Path Correlation	0.962832
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.85714
Average % Of Corr. Nodes	47.6853
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.0481
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• alpha-adrenergic receptor activity • G protein-coupled amine receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • adrenergic receptor activity • alpha2-adrenergic receptor activity • protein heterodimerization activity • protein binding • binding • protein dimerization activity • identical protein binding • protein homodimerization activity • GTPase regulator activity • enzyme regulator activity • guanyl-nucleotide exchange factor activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • adrenergic receptor binding • signaling receptor binding • G protein-coupled receptor binding • alpha-2A adrenergic receptor binding • epinephrine binding • cation binding • ion binding • catecholamine binding • hormone binding • small molecule binding • UDP-glycosyltransferase activity • alpha-1,4-glucan glucosyltransferase (NDP-glucose donor) activity • glycosyltransferase activity • alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity • transferase activity • glucosyltransferase activity • hexosyltransferase activity • catalytic activity • UDP-glucosyltransferase activity • regulation of biological process • signaling • biological regulation • cell-cell signaling • cellular process • cell communication • regulation of tube diameter • multicellular organismal process • system process • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction
Gene Ontology	Biological Process	• regulation of biological process • signaling • biological regulation • cell-cell signaling • cellular process • cell communication • regulation of tube diameter • multicellular organismal process • system process • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • cellular response to stimulus • positive regulation of cell communication • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • regulation of cellular process • positive regulation of signal transduction • response to stimulus • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • positive regulation of cellular process • regulation of signaling • positive regulation of intracellular signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • regulation of response to stimulus • regulation of cell communication • phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of signaling • muscle contraction • muscle system process • regulation of muscle system process • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • regulation of body fluid levels • wound healing • cell activation • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • platelet activation • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • cellular developmental process • regulation of developmental process • regulation of cell differentiation • positive regulation of neuron differentiation • positive regulation of developmental process • neurogenesis • multicellular organism development • neuron differentiation • positive regulation of cell differentiation • cell differentiation • anatomical structure development • system development • developmental process • nervous system development • generation of neurons • regulation of neuron differentiation • adrenergic receptor signaling pathway • G protein-coupled receptor signaling pathway • monoamine transport • negative regulation of amine transport • regulation of catecholamine secretion • epinephrine secretion • organic hydroxy compound transport • catecholamine transport • epinephrine transport • regulation of epinephrine secretion • negative regulation of catecholamine secretion • organic cation transport • catecholamine secretion • amine transport • negative regulation of epinephrine secretion • regulation of amine transport • negative regulation of norepinephrine secretion • norepinephrine transport • norepinephrine secretion • regulation of norepinephrine secretion • cell periphery • cellular anatomical structure • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • vesicle
SCOP2	Domain Identifier	• Type B glycosyltransferase-like
SCOP2	Family Identifier	• Type B glycosyltransferase-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	E33
PDB Residues	L:L:?1 M:M:?1
Environment Details	Open EMBL-EBI Page
Code	E33
Name	(8~{a}~{R},12~{a}~{S},13~{a}~{R})-12-ethylsulfonyl-3-methoxy-5,6,8,8~{a},9,10,11,12~{a},13,13~{a}-decahydroisoquinolino[2,1-g][1,6]naphthyridine
Synonyms
Identifier
Formula	C19 H28 N2 O3 S
Molecular Weight	364.502
SMILES
PubChem	57213234
Formal Charge	0
Total Atoms	53
Total Chiral Atoms	3
Total Bonds	56
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P18825
Sequence	>6KUW_poly_Chain_R P P R G Q Y S A G A V A G L A A V V G F L I V F T V V G N V L V V I A V L T S R A L R A P Q N L F L V S L A S A D I L V A T L V M P F S L A N E L M A Y W Y F G Q W W C G V Y L A L D V L F C T S S A V H L C A I S L D R Y W S V T Q A V E Y N L K R T P R R V K A T I V A V W L I S A V I S F P P L V S L A A Y P Q C G L N D E T W Y I L S S C I G S F F A P C L I M G L V Y A R I Y R V A K L R T V A Q A R E K R F T F V L A V V M G V W V L C W F P F F F S Y S L Y G I C R E A C Q V P G P L F K F F F W I G Y C N S S L N P V I Y T V F N Q D F R R S F K H I L F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6KUW	A	Amine	Adrenergic	α_2c	Homo sapiens	PubChem 57213234	-	-	2.8	2019-12-04	doi.org/10.1038/nature06325

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