psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:A1	L:L:F4	4.16	No	Yes	0	0	0
2	L:L:N3	L:L:S2	2.98	No	No	0	0	0
3	L:L:S2	R:R:K298	3.06	No	No	0	0	5
4	L:L:F4	R:R:T191	3.89	Yes	No	2	0	3
5	L:L:F4	R:R:Q192	4.68	Yes	No	0	0	2
6	L:L:F4	R:R:V196	2.62	Yes	No	2	0	3
7	L:L:D5	R:R:L35	6.79	No	No	0	0	4
8	L:L:D5	R:R:Q192	6.53	No	No	0	0	2
9	L:L:C6	L:L:Q26	3.05	No	Yes	8	0	0
10	L:L:C32	L:L:C6	7.28	No	No	8	0	0
11	L:L:C7	L:L:Q26	4.58	No	Yes	0	0	0
12	L:L:C48	L:L:C7	7.28	No	No	0	0	0
13	L:L:G9	L:L:L8	1.71	No	Yes	0	0	0
14	L:L:L8	R:R:R286	6.07	Yes	Yes	3	0	3
15	L:L:G9	R:R:M33	6.99	No	No	0	0	1
16	L:L:I34	L:L:Y10	10.88	No	Yes	0	0	0
17	L:L:A36	L:L:Y10	2.67	No	Yes	0	0	0
18	L:L:N50	L:L:Y10	6.98	No	Yes	0	0	0
19	L:L:Y10	R:R:M284	4.79	Yes	No	0	0	1
20	L:L:D12	L:L:V47	4.38	Yes	No	0	0	0
21	L:L:D12	R:R:V29	2.92	Yes	No	9	0	3
22	L:L:D12	R:R:E32	6.5	Yes	No	9	0	2
23	L:L:D12	R:R:M33	5.54	Yes	No	0	0	1
24	L:L:I14	L:L:W55	8.22	No	Yes	0	0	0
25	L:L:F19	L:L:L15	2.44	No	No	0	0	0
26	L:L:I20	L:L:L15	2.85	Yes	No	0	0	0
27	L:L:H16	L:L:P17	10.68	No	No	0	0	0
28	L:L:H16	L:L:K18	9.17	No	No	0	0	0
29	L:L:P17	L:L:W55	5.4	No	Yes	5	0	0
30	L:L:I59	L:L:P17	8.47	Yes	No	5	0	0
31	L:L:F19	R:R:Y27	6.19	No	No	0	0	6
32	L:L:F39	L:L:I20	8.79	Yes	Yes	5	0	0
33	L:L:I20	L:L:I59	4.42	Yes	Yes	5	0	0
34	L:L:I20	L:L:L63	2.85	Yes	No	0	0	0
35	L:L:G22	L:L:V21	3.68	No	No	0	0	0
36	L:L:K42	L:L:V21	6.07	No	No	0	0	0
37	L:L:F23	L:L:F39	2.14	No	Yes	0	0	0
38	L:L:F23	L:L:V60	5.24	No	No	0	0	0
39	L:L:I38	L:L:T24	3.04	Yes	No	0	0	0
40	L:L:I37	L:L:R25	6.26	Yes	No	0	0	0
41	L:L:C32	L:L:Q26	9.16	No	Yes	8	0	0
42	L:L:A36	L:L:Q26	3.03	No	Yes	0	0	0
43	L:L:E30	L:L:L27	11.93	No	No	0	0	0
44	L:L:A28	L:L:N35	4.69	No	No	0	0	0
45	L:L:E30	R:R:Y189	12.35	No	Yes	2	0	2
46	L:L:E30	R:R:K200	10.8	No	Yes	2	0	5
47	L:L:D33	L:L:I34	8.4	No	No	0	0	0
48	L:L:D33	R:R:R286	8.34	No	Yes	0	0	3
49	L:L:N35	L:L:P51	4.89	No	Yes	0	0	0
50	L:L:F39	L:L:I37	3.77	Yes	Yes	0	0	0
51	L:L:I37	L:L:V56	6.14	Yes	No	0	0	0
52	L:L:H40	L:L:I38	2.65	No	Yes	0	0	0
53	L:L:F39	L:L:I59	3.77	Yes	Yes	5	0	0
54	L:L:L45	L:L:T41	4.42	No	No	0	0	0
55	L:L:K43	L:L:L45	2.82	No	No	0	0	0
56	L:L:S46	R:R:L35	7.51	No	No	0	0	4
57	L:L:N50	L:L:P51	4.89	No	Yes	0	0	0
58	L:L:N50	L:L:Q53	3.96	No	No	0	0	0
59	L:L:W55	L:L:Y58	7.72	Yes	No	0	0	0
60	L:L:I59	L:L:W55	4.7	Yes	Yes	5	0	0
61	L:L:R61	L:L:Y58	2.06	No	No	0	0	0
62	L:L:L62	L:L:Y58	5.86	No	No	0	0	0
63	R:R:S28	R:R:Y27	7.63	No	No	0	3	6
64	R:R:E32	R:R:V29	5.7	No	No	9	2	3
65	R:R:D30	R:R:S31	8.83	No	No	0	4	2
66	R:R:C288	R:R:C36	5.46	No	No	3	7	5
67	R:R:L38	R:R:V41	4.47	No	No	0	3	3
68	R:R:Q39	R:R:R42	3.5	No	No	0	4	4
69	R:R:E40	R:R:V41	2.85	No	No	0	3	3
70	R:R:E40	R:R:K292	5.4	No	No	0	3	3
71	R:R:V41	R:R:Y296	6.31	No	No	0	3	2
72	R:R:Q192	R:R:R42	2.34	No	No	0	2	4
73	R:R:S45	R:R:V49	4.85	No	Yes	0	4	5
74	R:R:F48	R:R:T299	2.59	No	No	0	4	5
75	R:R:P50	R:R:V49	3.53	No	Yes	0	6	5
76	R:R:V49	R:R:Y53	3.79	Yes	Yes	0	5	8
77	R:R:H106	R:R:V49	12.45	No	Yes	0	5	5
78	R:R:L99	R:R:Y53	8.21	No	Yes	0	8	8
79	R:R:F306	R:R:Y53	5.16	Yes	Yes	0	7	8
80	R:R:F59	R:R:L55	2.44	No	No	0	5	5
81	R:R:C57	R:R:V96	3.42	No	No	0	6	6
82	R:R:C57	R:R:P100	3.77	No	No	0	6	9
83	R:R:I93	R:R:L61	2.85	Yes	No	0	7	6
84	R:R:L61	R:R:V96	2.98	No	No	0	6	6
85	R:R:G63	R:R:V314	1.84	No	No	0	7	6
86	R:R:D92	R:R:N64	14.81	No	No	1	9	9
87	R:R:I93	R:R:N64	2.83	Yes	No	0	7	9
88	R:R:N64	R:R:P313	4.89	No	No	1	9	9
89	R:R:I65	R:R:I93	2.94	No	Yes	0	4	7
90	R:R:F318	R:R:L66	2.44	Yes	No	0	6	6
91	R:R:F327	R:R:L66	8.53	No	No	0	6	6
92	R:R:F71	R:R:V67	2.62	No	No	6	7	8
93	R:R:F318	R:R:V67	2.62	Yes	No	6	6	8
94	R:R:F323	R:R:V67	5.24	Yes	No	6	8	8
95	R:R:F73	R:R:I69	2.51	No	No	0	4	4
96	R:R:F323	R:R:T70	6.49	Yes	No	0	8	7
97	R:R:F327	R:R:T70	5.19	No	No	0	6	7
98	R:R:F71	R:R:R78	3.21	No	Yes	0	7	7
99	R:R:F323	R:R:F71	8.57	Yes	No	6	8	7
100	R:R:F73	R:R:I330	10.05	No	Yes	0	4	5
101	R:R:Y326	R:R:Y74	36.74	No	No	0	5	5
102	R:R:K75	R:R:R78	2.48	No	Yes	0	6	7
103	R:R:R78	R:R:V83	2.62	Yes	No	0	7	6
104	R:R:L86	R:R:R78	4.86	No	Yes	0	6	7
105	R:R:M80	R:R:S79	3.07	No	No	0	6	8
106	R:R:M80	R:R:R159	8.69	No	Yes	0	6	5
107	R:R:D82	R:R:T81	4.34	No	No	0	8	8
108	R:R:L85	R:R:T81	2.95	No	No	0	8	8
109	R:R:C168	R:R:V83	1.71	No	No	0	7	6
110	R:R:C138	R:R:Y84	4.03	No	Yes	0	6	7
111	R:R:I139	R:R:Y84	3.63	No	Yes	0	9	7
112	R:R:D142	R:R:Y84	3.45	No	Yes	0	8	7
113	R:R:S164	R:R:Y84	3.82	No	Yes	0	7	7
114	R:R:I167	R:R:Y84	3.63	No	Yes	0	5	7
115	R:R:C168	R:R:Y84	2.69	No	Yes	0	7	7
116	R:R:L85	R:R:Y316	3.52	No	Yes	0	8	9
117	R:R:L135	R:R:N87	2.75	No	No	0	7	9
118	R:R:C168	R:R:N87	4.72	No	No	0	7	9
119	R:R:L135	R:R:M88	2.83	No	No	0	7	9
120	R:R:L136	R:R:M88	2.83	No	No	0	8	9
121	R:R:I139	R:R:M88	2.92	No	No	0	9	9
122	R:R:D92	R:R:P313	4.83	No	No	1	9	9
123	R:R:L94	R:R:N128	5.49	No	No	0	6	8
124	R:R:F95	R:R:Y125	7.22	Yes	No	10	6	7
125	R:R:F95	R:R:N128	6.04	Yes	No	0	6	8
126	R:R:F129	R:R:F95	3.22	No	Yes	0	7	6
127	R:R:F306	R:R:F95	3.22	Yes	Yes	10	7	6
128	R:R:C309	R:R:F95	2.79	No	Yes	0	8	6
129	R:R:I124	R:R:T98	3.04	No	No	0	5	6
130	R:R:F101	R:R:L121	4.87	No	No	0	6	5
131	R:R:W102	R:R:W111	3.75	No	Yes	0	6	8
132	R:R:W102	R:R:Y125	13.5	No	No	0	6	7
133	R:R:S105	R:R:W111	4.94	No	Yes	0	5	8
134	R:R:G109	R:R:T108	3.64	No	No	0	4	3
135	R:R:A110	R:R:S194	3.42	No	No	0	4	3
136	R:R:F113	R:R:W111	7.02	Yes	Yes	4	7	8
137	R:R:T117	R:R:W111	2.43	Yes	Yes	4	5	8
138	R:R:C118	R:R:W111	5.22	No	Yes	4	9	8
139	R:R:L121	R:R:W111	2.28	No	Yes	4	5	8
140	R:R:K188	R:R:W111	4.64	No	Yes	0	4	8
141	R:R:C197	R:R:W111	10.45	No	Yes	4	9	8
142	R:R:F113	R:R:V112	3.93	Yes	No	0	7	3
143	R:R:F113	R:R:T117	6.49	Yes	Yes	4	7	5
144	R:R:K119	R:R:N115	4.2	No	No	0	7	4
145	R:R:K188	R:R:N115	4.2	No	No	0	4	4
146	R:R:L121	R:R:T117	2.95	No	Yes	4	5	5
147	R:R:C118	R:R:C197	7.28	No	No	4	9	9
148	R:R:K122	R:R:N186	12.59	No	No	0	5	5
149	R:R:C197	R:R:K122	3.23	No	No	0	9	5
150	R:R:F183	R:R:G123	9.03	No	No	0	5	6
151	R:R:I124	R:R:N128	4.25	No	No	0	5	8
152	R:R:F306	R:R:Y125	7.22	Yes	No	10	7	7
153	R:R:A126	R:R:S179	3.42	No	No	0	5	6
154	R:R:A126	R:R:T182	5.03	No	No	0	5	4
155	R:R:I127	R:R:S175	3.1	No	Yes	0	5	7
156	R:R:I127	R:R:S179	7.74	No	No	0	5	6
157	R:R:F183	R:R:I127	2.51	No	No	0	5	5
158	R:R:F129	R:R:M133	3.73	No	No	0	7	7
159	R:R:I178	R:R:N130	4.25	No	No	0	4	7
160	R:R:N130	R:R:S179	2.98	No	No	0	7	6
161	R:R:C131	R:R:V171	1.71	No	Yes	0	7	6
162	R:R:C131	R:R:W172	11.75	No	No	11	7	9
163	R:R:C131	R:R:S175	3.44	No	Yes	11	7	7
164	R:R:L134	R:R:V171	4.47	No	Yes	0	5	6
165	R:R:L135	R:R:V171	2.98	No	Yes	0	7	6
166	R:R:L136	R:R:N312	6.87	No	Yes	1	8	9
167	R:R:L136	R:R:Y316	2.34	No	Yes	1	8	9
168	R:R:F229	R:R:T137	9.08	No	No	0	6	7
169	R:R:C138	R:R:V171	1.71	No	Yes	0	6	6
170	R:R:I139	R:R:R143	3.76	No	No	0	9	9
171	R:R:C233	R:R:S140	3.44	Yes	No	0	7	9
172	R:R:S140	R:R:Y234	6.36	No	Yes	0	9	9
173	R:R:F229	R:R:M141	4.98	No	No	0	6	6
174	R:R:C233	R:R:M141	3.24	Yes	No	0	7	6
175	R:R:D142	R:R:R159	8.34	No	Yes	0	8	5
176	R:R:R143	R:R:Y234	6.17	No	Yes	0	9	9
177	R:R:R143	R:R:Y316	4.12	No	Yes	0	9	9
178	R:R:V148	R:R:Y144	11.36	No	No	0	7	8
179	R:R:C233	R:R:Y144	2.69	Yes	No	0	7	8
180	R:R:I145	R:R:S153	3.1	No	No	0	4	6
181	R:R:A146	R:R:R159	4.15	No	Yes	0	8	5
182	R:R:K152	R:R:Q149	6.78	No	No	0	4	7
183	R:R:K152	R:R:R155	3.71	No	No	0	4	5
184	R:R:S153	R:R:S158	3.26	No	No	0	6	6
185	R:R:L156	R:R:R155	6.07	No	No	0	5	5
186	R:R:P162	R:R:T160	3.5	No	No	0	4	5
187	R:R:L161	R:R:P162	3.28	No	No	0	2	4
188	R:R:K165	R:R:L161	2.82	No	No	0	3	2
189	R:R:I167	R:R:R163	3.76	No	No	0	5	2
190	R:R:S175	R:R:W172	2.47	Yes	No	11	7	9
191	R:R:F221	R:R:I178	6.28	No	No	0	3	4
192	R:R:N186	R:R:T182	4.39	No	No	0	5	4
193	R:R:F185	R:R:V184	5.24	Yes	No	0	4	4
194	R:R:F185	R:R:Y201	15.47	Yes	Yes	7	4	6
195	R:R:F185	R:R:V204	2.62	Yes	No	7	4	2
196	R:R:F185	R:R:W210	2	Yes	No	7	4	2
197	R:R:N186	R:R:P199	6.52	No	No	0	5	5
198	R:R:K200	R:R:Q187	5.42	Yes	No	2	5	4
199	R:R:Q187	R:R:Q202	6.4	No	No	2	4	5
200	R:R:D195	R:R:K188	4.15	No	No	0	4	4
201	R:R:T191	R:R:Y189	8.74	No	Yes	2	3	2
202	R:R:E198	R:R:Y189	4.49	No	Yes	0	3	2
203	R:R:K200	R:R:Y189	8.36	Yes	Yes	2	5	2
204	R:R:D195	R:R:N190	4.04	No	No	0	4	4
205	R:R:T191	R:R:V196	3.17	No	No	2	3	3
206	R:R:E198	R:R:P199	11	No	No	0	3	5
207	R:R:P199	R:R:Y201	4.17	No	Yes	0	5	6
208	R:R:K200	R:R:Q202	6.78	Yes	No	2	5	5
209	R:R:W210	R:R:Y201	1.93	No	Yes	7	2	6
210	R:R:K211	R:R:Y201	7.17	No	Yes	0	4	6
211	R:R:M214	R:R:Y201	7.18	No	Yes	0	5	6
212	R:R:V204	R:R:W210	17.16	No	No	7	2	2
213	R:R:E206	R:R:R209	5.82	No	No	0	3	1
214	R:R:G216	R:R:L215	1.71	No	Yes	0	5	5
215	R:R:L215	R:R:L274	2.77	Yes	No	0	5	6
216	R:R:L215	R:R:T277	2.95	Yes	No	0	5	4
217	R:R:G216	R:R:L219	1.71	No	No	0	5	6
218	R:R:F221	R:R:L217	2.44	No	No	0	3	3
219	R:R:E218	R:R:L274	5.3	No	No	0	5	6
220	R:R:F224	R:R:L219	2.44	No	No	0	4	6
221	R:R:L219	R:R:L274	2.77	No	No	0	6	6
222	R:R:I225	R:R:L220	2.85	No	No	0	5	5
223	R:R:F221	R:R:I225	5.02	No	No	0	3	5
224	R:R:F223	R:R:F224	5.36	Yes	No	0	8	4
225	R:R:F223	R:R:L227	3.65	Yes	No	0	8	5
226	R:R:F223	R:R:Q267	2.34	Yes	Yes	1	8	9
227	R:R:F223	R:R:I268	2.51	Yes	No	0	8	6
228	R:R:F223	R:R:N271	15.71	Yes	No	1	8	8
229	R:R:I225	R:R:P226	3.39	No	No	0	5	9
230	R:R:L227	R:R:M228	4.24	No	No	0	5	4
231	R:R:I231	R:R:L227	2.85	No	No	0	5	5
232	R:R:M230	R:R:Y234	3.59	No	Yes	0	7	9
233	R:R:F263	R:R:M230	7.46	No	No	0	9	7
234	R:R:F232	R:R:F236	6.43	No	No	0	5	4
235	R:R:I237	R:R:Y234	2.42	No	Yes	0	8	9
236	R:R:I256	R:R:Y234	6.04	No	Yes	0	7	9
237	R:R:V260	R:R:Y234	3.79	No	Yes	0	8	9
238	R:R:F236	R:R:K239	2.48	No	No	0	4	4
239	R:R:I256	R:R:V238	4.61	No	No	0	7	5
240	R:R:K248	R:R:N246	8.39	No	No	0	5	4
241	R:R:H250	R:R:R249	9.03	No	No	0	5	7
242	R:R:I319	R:R:V255	3.07	No	No	0	7	7
243	R:R:V259	R:R:Y316	3.79	No	Yes	0	7	9
244	R:R:C266	R:R:V262	1.71	No	No	1	7	7
245	R:R:H308	R:R:V262	2.77	Yes	No	1	9	7
246	R:R:F263	R:R:Q267	7.03	No	Yes	1	9	9
247	R:R:F263	R:R:H308	4.53	No	Yes	1	9	9
248	R:R:I268	R:R:L264	2.85	No	No	0	6	6
249	R:R:C266	R:R:H308	10.32	No	Yes	1	7	9
250	R:R:N271	R:R:Q267	2.64	No	Yes	1	8	9
251	R:R:H308	R:R:Q267	8.65	Yes	Yes	1	9	9
252	R:R:I268	R:R:P269	3.39	No	No	0	6	9
253	R:R:P269	R:R:T301	3.5	No	No	0	9	6
254	R:R:E302	R:R:H270	2.46	No	No	0	6	7
255	R:R:T301	R:R:V273	7.93	No	No	0	6	5
256	R:R:I294	R:R:V276	3.07	No	No	0	4	5
257	R:R:K283	R:R:N280	4.2	No	No	3	1	4
258	R:R:N280	R:R:R286	3.62	No	Yes	3	4	3
259	R:R:K283	R:R:R286	3.71	No	Yes	3	1	3
260	R:R:E291	R:R:R286	6.98	No	Yes	0	4	3
261	R:R:E302	R:R:F306	2.33	No	Yes	0	6	7
262	R:R:H308	R:R:N312	6.38	Yes	Yes	1	9	9
263	R:R:N312	R:R:P313	3.26	Yes	No	1	9	9
264	R:R:N312	R:R:Y316	6.98	Yes	Yes	1	9	9
265	R:R:F318	R:R:V314	2.62	Yes	No	0	6	6
266	R:R:I319	R:R:L315	2.85	No	No	0	7	8
267	R:R:A317	R:R:F323	5.55	No	Yes	0	6	8
268	R:R:F318	R:R:F323	2.14	Yes	Yes	6	6	8
269	R:R:Q321	R:R:R324	5.84	No	No	0	5	8
270	R:R:N325	R:R:Q321	6.6	No	No	0	4	5
271	R:R:K329	R:R:Y326	2.39	No	No	0	4	5
272	R:R:I330	R:R:Y326	4.84	Yes	No	0	5	5
273	R:R:D333	R:R:I330	2.8	No	Yes	0	4	5
274	R:R:D333	R:R:L334	2.71	No	No	0	4	5
275	L:L:N3	R:R:G295	1.7	No	No	0	0	5
276	L:L:A49	L:L:V56	1.7	No	No	0	0	0
277	R:R:A52	R:R:V303	1.7	No	No	0	5	4
278	R:R:A89	R:R:V68	1.7	No	No	0	9	7
279	L:L:I37	L:L:P51	1.69	Yes	Yes	0	0	0
280	L:L:D33	R:R:G282	1.68	No	No	0	0	2
281	L:L:K52	L:L:P51	1.67	No	Yes	0	0	0
282	L:L:C48	L:L:I38	1.64	No	Yes	0	0	0
283	R:R:E218	R:R:G222	1.64	No	No	0	5	6
284	L:L:N29	R:R:P207	1.63	No	No	0	0	2
285	R:R:S287	R:R:S290	1.63	No	No	0	6	1
286	R:R:S175	R:R:V176	1.62	Yes	No	0	7	4
287	R:R:S114	R:R:T117	1.6	No	Yes	0	7	5
288	R:R:V238	R:R:V242	1.6	No	No	0	5	5
289	R:R:V255	R:R:V259	1.6	No	No	0	7	7
290	L:L:L8	R:R:C36	1.59	Yes	No	3	0	5
291	L:L:L8	R:R:C288	1.59	Yes	No	3	0	7
292	L:L:T41	L:L:V47	1.59	No	No	0	0	0
293	R:R:C36	R:R:L38	1.59	No	No	0	5	3
294	R:R:T299	R:R:V49	1.59	No	Yes	0	5	5
295	R:R:A278	R:R:L215	1.58	No	Yes	0	5	5
296	R:R:A252	R:R:L241	1.58	No	No	0	7	8
297	R:R:E206	R:R:P207	1.57	No	No	0	3	2
298	R:R:C310	R:R:D92	1.56	No	No	0	6	9
299	R:R:A279	R:R:N280	1.56	No	No	0	5	4
300	L:L:I38	L:L:S46	1.55	Yes	No	0	0	0
301	R:R:I294	R:R:S290	1.55	No	No	0	4	1
302	R:R:I90	R:R:V68	1.54	No	No	0	6	7
303	R:R:I93	R:R:V68	1.54	Yes	No	0	7	7
304	R:R:I253	R:R:V242	1.54	No	No	0	6	5
305	R:R:K165	R:R:S164	1.53	No	No	0	3	7
306	R:R:I330	R:R:T70	1.52	Yes	No	0	5	7
307	R:R:I147	R:R:T240	1.52	No	No	0	8	5
308	R:R:I231	R:R:T235	1.52	No	No	0	5	3
309	R:R:K251	R:R:V255	1.52	No	No	0	7	7
310	R:R:K298	R:R:V273	1.52	No	No	0	5	5
311	L:L:F4	L:L:G31	1.51	Yes	No	0	0	0
312	R:R:L55	R:R:S54	1.5	No	No	0	5	6
313	R:R:L174	R:R:V170	1.49	No	No	0	3	3
314	R:R:L304	R:R:V303	1.49	No	No	0	7	4
315	R:R:I147	R:R:I237	1.47	No	No	0	8	8
316	R:R:I253	R:R:I257	1.47	No	No	0	6	5
317	R:R:L281	R:R:T277	1.47	No	No	0	5	4
318	R:R:Q39	R:R:S37	1.44	No	No	0	4	3
319	R:R:E40	R:R:S37	1.44	No	No	0	3	3
320	R:R:I56	R:R:L99	1.43	No	No	0	7	8
321	R:R:Q149	R:R:V148	1.43	No	No	0	7	7
322	R:R:I178	R:R:L174	1.43	No	No	0	4	3
323	R:R:I253	R:R:L241	1.43	No	No	0	6	8
324	R:R:Q243	R:R:V242	1.43	No	No	0	5	5
325	L:L:Q53	L:L:T54	1.42	No	No	0	0	0
326	R:R:Q202	R:R:T203	1.42	No	No	0	5	2
327	R:R:C233	R:R:F232	1.4	Yes	No	0	7	5
328	R:R:K283	R:R:N285	1.4	No	No	0	1	4
329	R:R:D82	R:R:K322	1.38	No	No	0	8	7
330	R:R:L304	R:R:L307	1.38	No	No	0	7	5
331	L:L:L27	L:L:N29	1.37	No	No	0	0	0
332	R:R:K251	R:R:Q321	1.36	No	No	0	7	5
333	R:R:A103	R:R:Y53	1.33	No	Yes	0	6	8
334	R:R:R159	R:R:S153	1.32	Yes	No	0	5	6
335	R:R:R163	R:R:S158	1.32	No	No	0	2	6
336	R:R:F59	R:R:V58	1.31	No	No	0	5	5
337	R:R:F113	R:R:V104	1.31	Yes	No	0	7	4
338	R:R:R157	R:R:T160	1.29	No	No	0	6	5
339	R:R:Q39	R:R:Q43	1.28	No	No	0	4	4
340	L:L:I14	L:L:R13	1.25	No	No	0	0	0
341	R:R:F48	R:R:L47	1.22	No	No	0	4	4
342	R:R:L241	R:R:R249	1.21	No	No	0	8	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F4	3.372	5	2	0
2	L:L:L8	2.74	4	3	0
3	L:L:Y10	6.33	4	0	0
4	L:L:D12	4.835	4	9	0
5	L:L:I20	4.7275	4	5	0
6	L:L:Q26	4.955	4	8	0
7	L:L:I37	4.465	4	0	0
8	L:L:I38	2.22	4	0	0
9	L:L:F39	4.6175	4	5	0
10	L:L:P51	3.285	4	0	0
11	L:L:W55	6.51	4	5	0
12	L:L:I59	5.34	4	5	0
13	R:R:V49	5.242	5	0	5
14	R:R:Y53	4.6225	4	0	8
15	R:R:R78	3.2925	4	0	7
16	R:R:Y84	3.54167	6	0	7
17	R:R:I93	2.54	4	0	7
18	R:R:F95	4.498	5	10	6
19	R:R:W111	5.09125	8	4	8
20	R:R:F113	4.6875	4	4	7
21	R:R:T117	3.3675	4	4	5
22	R:R:R159	5.625	4	0	5
23	R:R:V171	2.7175	4	0	6
24	R:R:S175	2.6575	4	11	7
25	R:R:F185	6.3325	4	7	4
26	R:R:Y189	8.485	4	2	2
27	R:R:K200	7.84	4	2	5
28	R:R:Y201	7.184	5	7	6
29	R:R:L215	2.2525	4	0	5
30	R:R:F223	5.914	5	1	8
31	R:R:C233	2.6925	4	0	7
32	R:R:Y234	4.72833	6	0	9
33	R:R:Q267	5.165	4	1	9
34	R:R:R286	5.744	5	3	3
35	R:R:F306	4.4825	4	10	7
36	R:R:H308	6.53	5	1	9
37	R:R:N312	5.8725	4	1	9
38	R:R:Y316	4.15	5	1	9
39	R:R:F318	2.455	4	6	6
40	R:R:F323	5.598	5	6	8
41	R:R:I330	4.8025	4	0	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F4	R:R:T191	67.8059	3.89	Yes	No	2	0	3
2	R:R:T191	R:R:Y189	69.3033	8.74	No	Yes	2	3	2
3	R:R:E198	R:R:Y189	75.7982	4.49	No	Yes	0	3	2
4	R:R:E198	R:R:P199	76.3521	11	No	No	0	3	5
5	R:R:N186	R:R:P199	81.0634	6.52	No	No	0	5	5
6	R:R:N186	R:R:T182	96.5304	4.39	No	No	0	5	4
7	R:R:A126	R:R:T182	96.7678	5.03	No	No	0	5	4
8	R:R:A126	R:R:S179	96.9991	3.42	No	No	0	5	6
9	R:R:I127	R:R:S179	98.9774	7.74	No	No	0	5	6
10	R:R:I127	R:R:S175	99.4522	3.1	No	Yes	0	5	7
11	R:R:C131	R:R:S175	99.2513	3.44	No	Yes	11	7	7
12	R:R:C131	R:R:V171	100	1.71	No	Yes	0	7	6
13	R:R:L135	R:R:V171	62.0477	2.98	No	Yes	0	7	6
14	R:R:L135	R:R:M88	52.1959	2.83	No	No	0	7	9
15	R:R:L136	R:R:M88	42.2954	2.83	No	No	0	8	9
16	R:R:L136	R:R:N312	35.128	6.87	No	Yes	1	8	9
17	R:R:H308	R:R:N312	32.3736	6.38	Yes	Yes	1	9	9
18	R:R:H308	R:R:Q267	29.1232	8.65	Yes	Yes	1	9	9
19	R:R:F223	R:R:Q267	33.9136	2.34	Yes	Yes	1	8	9
20	R:R:F223	R:R:I268	11.4466	2.51	Yes	No	0	8	6
21	L:L:F4	R:R:Q192	66.1077	4.68	Yes	No	0	0	2
22	L:L:D5	R:R:Q192	40.2563	6.53	No	No	0	0	2
23	L:L:D5	R:R:L35	39.4284	6.79	No	No	0	0	4
24	L:L:S46	R:R:L35	38.631	7.51	No	No	0	0	4
25	L:L:I38	L:L:S46	37.8915	1.55	Yes	No	0	0	0
26	L:L:C48	L:L:I38	35.6636	1.64	No	Yes	0	0	0
27	L:L:C48	L:L:C7	34.9088	7.28	No	No	0	0	0
28	L:L:C7	L:L:Q26	34.1571	4.58	No	Yes	0	0	0
29	R:R:Q192	R:R:R42	26.0858	2.34	No	No	0	2	4
30	R:R:Q39	R:R:R42	25.1545	3.5	No	No	0	4	4
31	R:R:Q39	R:R:S37	23.6631	1.44	No	No	0	4	3
32	R:R:E40	R:R:S37	22.9144	1.44	No	No	0	3	3
33	R:R:E40	R:R:V41	21.4353	2.85	No	No	0	3	3
34	R:R:L38	R:R:V41	19.944	4.47	No	No	0	3	3
35	R:R:C36	R:R:L38	19.1953	1.59	No	No	0	5	3
36	L:L:L8	R:R:C36	17.5336	1.59	Yes	No	3	0	5
37	L:L:L8	R:R:R286	10.0618	6.07	Yes	Yes	3	0	3
38	L:L:A36	L:L:Q26	31.9719	3.03	No	Yes	0	0	0
39	L:L:A36	L:L:Y10	31.2201	2.67	No	Yes	0	0	0
40	L:L:N50	L:L:Y10	30.5719	6.98	No	Yes	0	0	0
41	L:L:N50	L:L:P51	27.7597	4.89	No	Yes	0	0	0
42	L:L:I37	L:L:P51	23.9249	1.69	Yes	Yes	0	0	0
43	L:L:F39	L:L:I37	19.9897	3.77	Yes	Yes	0	0	0
44	L:L:F39	L:L:I59	10.6035	3.77	Yes	Yes	5	0	0
45	R:R:K122	R:R:N186	40.4267	12.59	No	No	0	5	5
46	R:R:C197	R:R:K122	39.5623	3.23	No	No	0	9	5
47	R:R:C197	R:R:W111	37.6997	10.45	No	Yes	4	9	8
48	R:R:W102	R:R:W111	24.9049	3.75	No	Yes	0	6	8
49	R:R:W102	R:R:Y125	23.9371	13.5	No	No	0	6	7
50	R:R:F306	R:R:Y125	14.6118	7.22	Yes	No	10	7	7
51	R:R:F306	R:R:Y53	11.8483	5.16	Yes	Yes	0	7	8
52	R:R:N312	R:R:P313	14.5175	3.26	Yes	No	1	9	9
53	R:R:N64	R:R:P313	11.197	4.89	No	No	1	9	9
54	R:R:I93	R:R:N64	10.1592	2.83	Yes	No	0	7	9
55	R:R:L135	R:R:N87	18.404	2.75	No	No	0	7	9
56	R:R:C168	R:R:N87	17.844	4.72	No	No	0	7	9
57	R:R:C168	R:R:V83	44.9919	1.71	No	No	0	7	6
58	R:R:R78	R:R:V83	43.3332	2.62	Yes	No	0	7	6
59	R:R:F71	R:R:R78	38.3206	3.21	No	Yes	0	7	7
60	R:R:C138	R:R:V171	38.6006	1.71	No	Yes	0	6	6
61	R:R:C138	R:R:Y84	38.6067	4.03	No	Yes	0	6	7
62	R:R:C168	R:R:Y84	29.2053	2.69	No	Yes	0	7	7
63	R:R:F323	R:R:F71	27.9058	8.57	Yes	No	6	8	7
64	R:R:F323	R:R:T70	17.634	6.49	Yes	No	0	8	7
65	R:R:I330	R:R:T70	14.1796	1.52	Yes	No	0	5	7
66	R:R:I139	R:R:M88	23.1701	2.92	No	No	0	9	9
67	R:R:I139	R:R:Y84	39.6263	3.63	No	Yes	0	9	7
68	R:R:I139	R:R:R143	48.3519	3.76	No	No	0	9	9
69	R:R:R143	R:R:Y234	41.5497	6.17	No	Yes	0	9	9
70	R:R:S140	R:R:Y234	19.4692	6.36	No	Yes	0	9	9
71	R:R:C233	R:R:S140	18.1179	3.44	Yes	No	0	7	9
72	R:R:F223	R:R:F224	17.5944	5.36	Yes	No	0	8	4
73	R:R:F224	R:R:L219	16.377	2.44	No	No	0	4	6
74	R:R:I256	R:R:Y234	14.0275	6.04	No	Yes	0	7	9
75	R:R:I256	R:R:V238	12.6518	4.61	No	No	0	7	5
76	R:R:V238	R:R:V242	11.27	1.6	No	No	0	5	5
77	R:R:R143	R:R:Y316	11.0357	4.12	No	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:S2	R:R:K298	3.06	0	No	No	0	5	0	1
L:L:F4	R:R:T191	3.89	2	Yes	No	0	3	0	1
L:L:F4	R:R:Q192	4.68	2	Yes	No	0	2	0	1
L:L:F4	R:R:V196	2.62	2	Yes	No	0	3	0	1
L:L:D5	R:R:L35	6.79	0	No	No	0	4	0	1
L:L:D5	R:R:Q192	6.53	0	No	No	0	2	0	1
L:L:L8	R:R:R286	6.07	3	Yes	Yes	0	3	0	1
L:L:G9	R:R:M33	6.99	0	No	No	0	1	0	1
L:L:Y10	R:R:M284	4.79	0	Yes	No	0	1	0	1
L:L:D12	R:R:V29	2.92	9	Yes	No	0	3	0	1
L:L:D12	R:R:E32	6.5	9	Yes	No	0	2	0	1
L:L:D12	R:R:M33	5.54	9	Yes	No	0	1	0	1
L:L:F19	R:R:Y27	6.19	0	No	No	0	6	0	1
L:L:E30	R:R:Y189	12.35	2	No	Yes	0	2	0	1
L:L:E30	R:R:K200	10.8	2	No	Yes	0	5	0	1
L:L:D33	R:R:R286	8.34	0	No	Yes	0	3	0	1
L:L:S46	R:R:L35	7.51	0	No	No	0	4	0	1
R:R:S28	R:R:Y27	7.63	0	No	No	3	6	2	1
R:R:E32	R:R:V29	5.7	9	No	No	2	3	1	1
R:R:C288	R:R:C36	5.46	3	No	No	7	5	1	1
R:R:Q192	R:R:R42	2.34	0	No	No	2	4	1	2
R:R:K200	R:R:Q187	5.42	2	Yes	No	5	4	1	2
R:R:Q187	R:R:Q202	6.4	2	No	No	4	5	2	2
R:R:T191	R:R:Y189	8.74	2	No	Yes	3	2	1	1
R:R:E198	R:R:Y189	4.49	0	No	Yes	3	2	2	1
R:R:K200	R:R:Y189	8.36	2	Yes	Yes	5	2	1	1
R:R:T191	R:R:V196	3.17	2	No	No	3	3	1	1
R:R:K200	R:R:Q202	6.78	2	Yes	No	5	5	1	2
R:R:K283	R:R:N280	4.2	3	No	No	1	4	2	2
R:R:N280	R:R:R286	3.62	3	No	Yes	4	3	2	1
R:R:K283	R:R:R286	3.71	3	No	Yes	1	3	2	1
R:R:E291	R:R:R286	6.98	0	No	Yes	4	3	2	1
L:L:N3	R:R:G295	1.7	0	No	No	0	5	0	1
L:L:D33	R:R:G282	1.68	0	No	No	0	2	0	1
L:L:N29	R:R:P207	1.63	0	No	No	0	2	0	1
L:L:L8	R:R:C36	1.59	3	Yes	No	0	5	0	1
L:L:L8	R:R:C288	1.59	3	Yes	No	0	7	0	1
R:R:C36	R:R:L38	1.59	3	No	No	5	3	1	2
R:R:E206	R:R:P207	1.57	0	No	No	3	2	2	1
R:R:K298	R:R:V273	1.52	0	No	No	5	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6WWZ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.71
Number of Linked Nodes	320
Number of Links	342
Number of Hubs	41
Number of Links mediated by Hubs	161
Number of Communities	11
Number of Nodes involved in Communities	58
Number of Links involved in Communities	70

Path Summary
Number Of Nodes in MetaPath	78
Number Of Links MetaPath	77
Number of Shortest Paths	60839
Length Of Smallest Path	3
Average Path Length	20.2117
Length of Longest Path	47
Minimum Path Strength	1.32
Average Path Strength	4.62758
Maximum Path Strength	20.79
Minimum Path Correlation	0.7
Average Path Correlation	0.944109
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.63158
Average % Of Corr. Nodes	48.0218
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	30.4106
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • signaling receptor activity • G protein-coupled chemoattractant receptor activity • C-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • cytokine receptor activity • immune receptor activity • C-C chemokine binding • protein binding • chemokine binding • cytokine binding • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • humoral immune response • response to stimulus • immune response • immune system process • cellular response to stimulus • positive regulation of dendritic cell chemotaxis • positive regulation of locomotion
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • humoral immune response • response to stimulus • immune response • immune system process • cellular response to stimulus • positive regulation of dendritic cell chemotaxis • positive regulation of locomotion • regulation of cell motility • regulation of cellular process • regulation of response to external stimulus • dendritic cell chemotaxis • positive regulation of biological process • positive regulation of chemotaxis • positive regulation of cell migration • positive regulation of response to stimulus • positive regulation of response to external stimulus • taxis • positive regulation of cell motility • regulation of cell migration • positive regulation of mononuclear cell migration • cell migration • regulation of immune system process • cell motility • regulation of mononuclear cell migration • positive regulation of immune system process • locomotion • positive regulation of cellular process • cell chemotaxis • chemotaxis • regulation of biological process • regulation of dendritic cell chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • response to external stimulus • positive regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • regulation of chemotaxis • leukocyte migration • dendritic cell migration • cellular response to chemical stimulus • regulation of response to stimulus • response to chemical • regulation of locomotion • mononuclear cell migration • leukocyte chemotaxis • lymphocyte migration • T cell migration • signaling • intracellular signal transduction • cell communication • calcium-mediated signaling • intracellular signaling cassette • signal transduction • defense response • response to stress • inflammatory response • leukocyte migration involved in inflammatory response • adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • multicellular organismal process • lymphocyte mediated immunity • B cell activation involved in immune response • cell activation involved in immune response • nucleobase-containing compound metabolic process • multicellular organism development • anatomical structure development • leukocyte mediated immunity • somatic diversification of immune receptors • somatic recombination of immunoglobulin genes involved in immune response • system development • developmental process • DNA recombination • primary metabolic process • DNA metabolic process • immune effector process • somatic diversification of immunoglobulins • biosynthetic process • B cell mediated immunity • macromolecule metabolic process • isotype switching • immune system development • immunoglobulin production • immunoglobulin production involved in immunoglobulin-mediated immune response • somatic cell DNA recombination • lymphocyte activation • leukocyte activation • somatic diversification of immunoglobulins involved in immune response • somatic recombination of immunoglobulin gene segments • leukocyte activation involved in immune response • lymphocyte activation involved in immune response • production of molecular mediator of immune response • B cell activation • cell activation • isotype switching to IgA isotypes • gene expression • macromolecule biosynthetic process • immunoglobulin mediated immune response • adaptive immune response • nucleic acid metabolic process • somatic diversification of immune receptors via germline recombination within a single locus • regulation of lymphocyte migration • regulation of T cell migration • cellular developmental process • hemopoiesis • cell development • mononuclear cell differentiation • lymphocyte differentiation • T cell differentiation in thymus • T cell activation • cell differentiation • T cell differentiation • DN2 thymocyte differentiation • leukocyte differentiation • thymocyte migration • cellular defense response • regulation of reproductive process • cellular process involved in reproduction in multicellular organism • regulation of cilium-dependent cell motility • positive regulation of flagellated sperm motility • regulation of flagellated sperm motility • cell maturation • positive regulation of flagellated sperm motility involved in capacitation • positive regulation of cilium-dependent cell motility • regulation of microtubule-based movement • developmental maturation • regulation of cilium movement • sperm capacitation • anatomical structure maturation • flagellated sperm motility • germ cell development • microtubule-based movement • microtubule-based process • cilium movement • regulation of cilium movement involved in cell motility • spermatid development • spermatid differentiation • sexual reproduction • spermatogenesis • reproductive process • developmental process involved in reproduction • gamete generation • cilium or flagellum-dependent cell motility • cilium-dependent cell motility • positive regulation of cilium movement • positive regulation of reproductive process • sperm motility • multicellular organismal reproductive process • regulation of microtubule-based process • cilium movement involved in cell motility • male gamete generation • DN3 thymocyte differentiation • cellular anatomical structure • periplasmic space • cell periphery • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • membrane-bounded organelle • cell projection • organelle • cilium • 9+2 motile cilium • sperm flagellum
Gene Ontology	Cellular Component	• cellular anatomical structure • periplasmic space • cell periphery • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • membrane-bounded organelle • cell projection • organelle • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • sperm principal piece • sperm midpiece • sperm plasma membrane • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • postsynapse • postsynaptic membrane • synapse • cell junction • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • dendrite • dendritic tree • neuron projection • intracellular anatomical structure • cytoplasm • GABA-ergic synapse • glutamatergic synapse • cell body • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • adenylate cyclase-activating dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • molecular function activator activity • signaling receptor activator activity • cytokine receptor binding • chemokine activity • cytokine activity • signaling receptor regulator activity • chemokine receptor binding • receptor ligand activity • CCR chemokine receptor binding • CCR6 chemokine receptor binding • chemotaxis • taxis • response to external stimulus • locomotion • cell chemotaxis • cell migration • cell motility • immune response • immune system process • positive regulation of locomotion • regulation of cell motility • positive regulation of biological process • regulation of lymphocyte migration • positive regulation of cell migration • positive regulation of cell motility • regulation of cell migration • positive regulation of mononuclear cell migration • regulation of immune system process • regulation of mononuclear cell migration • positive regulation of immune system process • positive regulation of cellular process • positive regulation of lymphocyte migration • regulation of leukocyte migration • positive regulation of T cell migration • lymphocyte migration • positive regulation of leukocyte migration • leukocyte migration • regulation of locomotion • regulation of T cell migration • mononuclear cell migration • T cell migration • thymocyte migration • defense response • response to stress • inflammatory response • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • defense response to bacterium • biological process involved in interspecies interaction between organisms • response to other organism • response to bacterium • response to external biotic stimulus • response to biotic stimulus • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to oxygen levels • response to abiotic stimulus • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • organelle membrane • cell projection membrane
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Interleukin 8-like chemokines
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Interleukin 8-like chemokines
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P51684
Sequence	>6WWZ_nogp_Chain_R Y S V D S E M L L C S L Q E V R Q F S R L F V P I A Y S L I C V F G L L G N I L V V I T F A F Y K K A R S M T D V Y L L N M A I A D I L F V L T L P F W A V S H A T G A W V F S N A T C K L L K G I Y A I N F N C G M L L L T C I S M D R Y I A I V Q A T K S F R L R S R T L P R S K I I C L V V W G L S V I I S S S T F V F N Q K Y N T Q G S D V C E P K Y Q T V S E P I R W K L L M L G L E L L F G F F I P L M F M I F C Y T F I V K T L V Q A Q N S K R H K A I R V I I A V V L V F L A C Q I P H N M V L L V T A A N L G K M N R S C Q S E K L I G Y T K T V T E V L A F L H C C L N P V L Y A F I G Q K F R N Y F L K I L K D L W C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6WWZ	A	Protein	Chemokine	CCR6	Homo sapiens	CCL20	-	Go/β1/γ2	3.34	2020-06-24	doi.org/10.1038/s41467-020-16820-6
	6WWZ (No Gprot)	A	Protein	Chemokine	CCR6	Homo sapiens	CCL20	-		3.34	2020-06-24	doi.org/10.1038/s41467-020-16820-6

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