Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:R36 7.7775424
2R:R:A39 2.62425
3R:R:V45 2.695406
4R:R:F51 5.47143728
5R:R:H54 4.5025427
6R:R:R65 5.11333622
7R:R:C67 4.185427
8R:R:I76 5.644527
9R:R:R78 7.728525
10R:R:V79 5.2525
11R:R:E80 6.00667627
12R:R:M82 4.51833628
13R:R:F83 6.52429725
14R:R:H84 5.4975407
15R:R:T85 5.72254308
16R:R:I99 4.78505
17R:R:L101 4.92408
18R:R:E104 5.33754275
19R:R:I105 4.52857728
20R:R:R106 7.4965275
21R:R:C109 6.17427
22R:R:V114 5.505423
23R:R:E117 7.9325425
24R:R:F122 5.025276
25R:R:R124 8.9675407
26R:R:P155 3.4875404
27R:R:I160 4.038528
28R:R:P162 5.49754285
29R:R:I169 3.84405
30R:R:V171 3.964286
31R:R:L174 3.14754315
32R:R:L175 3.2875408
33R:R:F178 6.24406
34R:R:I180 2.6275407
35R:R:P181 3.534238
36R:R:Q182 5.91754288
37R:R:L192 7.0325407
38R:R:Y198 8.34754225
39R:R:Y200 5.99507
40R:R:F201 6.72143708
41R:R:R203 6.084329
42R:R:Q211 6.464509
43R:R:M215 3.6454117
44R:R:L216 3.3725356
45R:R:Y222 6.7475498
46R:R:W224 11.6325409
47R:R:Y226 6.6056189
48R:R:H231 7.055404
49R:R:Y236 4.574117
50R:R:M241 5.855404
51R:R:H257 7.7075435
52R:R:I261 4.785436
53R:R:S269 3.83534
54R:R:R272 4.7075434
55R:R:L273 4.855435
56R:R:L277 4.0675437
57R:R:R278 7.7775403
58R:R:R285 4.6845366
59R:R:V288 3.7585116
60R:R:F290 6.5645116
61R:R:V296 3.935434
62R:R:V309 5.33254196
63R:R:E311 7.01754364
64R:R:F312 3.84754367
65R:R:W320 6.195637
66R:R:Y330 6.023336194
67R:R:E333 7.0925194
68R:R:K341 6.145436
69R:R:L342 4.18754344
70R:R:F350 8.705428
71R:R:F354 5.945426
72R:R:N362 8.53524
73R:R:R364 6.348524
74R:R:N365 6.40167627
75R:R:W367 7.2575424
76R:R:F368 5.82725
77R:R:F371 6.928526
78R:R:W372 10.882528
79R:R:F376 14.28427
80R:R:R379 5.99754244
81R:R:P381 3.51754241
82R:R:E398 8.02427
83R:R:Y404 11.6575425
84R:R:Q406 6.886526
85R:R:D407 4.6075426
86R:R:K409 5.595404
87R:R:F412 5.13407
88R:R:V413 3.25428
89R:R:Y418 6.0365308
90R:R:Q425 4.41407
91R:R:M427 8.325405
92R:R:M442 6.028503
93R:R:L450 3.9854238
94R:R:L454 4.064237
95R:R:I455 1.865405
96R:R:F469 3.8365338
97R:R:D474 7.414327
98R:R:R478 12.535434
99R:R:Y479 6.258336348
100R:R:D480 8.8675437
101R:R:N483 3.9775498
102R:R:Y494 4.978534
103R:R:V497 2.655498
104R:R:T499 3.8975432
105R:R:W500 6.188506
106R:R:L505 4.0325495
107R:R:I507 4.10667696
108R:R:I512 4.8175497
109R:R:C524 7.22754189
110R:R:S525 2.8354189
111R:R:C550 5.39254149
112R:R:E554 3.6654147
113R:R:Y555 5.9485157
114R:R:Q557 5.39754156
115R:R:P571 5.78754157
116R:R:L575 7.1725405
117R:R:C578 5.224159
118R:R:R584 5.365446
119R:R:S593 2.335407
120R:R:F614 3.99333609
121R:R:T620 3.98409
122R:R:S627 4.2785169
123R:R:I638 5.244208
124R:R:Y642 5.823336208
125R:R:P645 3.165407
126R:R:K651 4.27333644
127R:R:Q660 5.675448
128R:R:R661 8.5675448
129R:R:Y672 7.125177
130R:R:R681 4.4554168
131R:R:R684 7.82407
132R:R:Q717 4.75254389
133R:R:I725 6.2575447
134R:R:P730 6.41449
135R:R:Y736 6.432544
136R:R:V742 6.1675448
137R:R:C746 5.1325449
138R:R:N760 3.82408
139R:R:I764 4.081437178
140R:R:T774 2.885408
141R:R:Y786 6.534405
142R:R:T790 4.2775409
143R:R:M791 5.6745179
144R:R:W798 4.225179
145R:R:F801 4.3685399
146R:R:Y805 9.83254399
147R:R:L827 4.384208
148R:R:F831 3.1356209
149R:R:K834 8.06254409
150S:S:R36 6.21167614
151S:S:A39 3.0875415
152S:S:M41 7.05414
153S:S:F51 5.92571718
154S:S:H54 4.02517
155S:S:H55 7.375412
156S:S:P57 3.27402
157S:S:V62 3.7875417
158S:S:R65 4.405412
159S:S:R71 8.71414
160S:S:Y74 4.7625415
161S:S:I76 4.88571717
162S:S:Q77 6.27417
163S:S:R78 6.346515
164S:S:V79 5.434515
165S:S:E80 4.75429717
166S:S:M82 5.226518
167S:S:F83 6.54667615
168S:S:L95 5.1525407
169S:S:I99 6.99405
170S:S:S103 3.045617
171S:S:E104 5.17754415
172S:S:I105 5.08286718
173S:S:R106 10.8075405
174S:S:D107 5.354519
175S:S:C109 5.3725417
176S:S:W110 6.04513
177S:S:E117 5.55415
178S:S:Q118 6.0525416
179S:S:F122 5.2875406
180S:S:R124 7.2075407
181S:S:R131 5.848522
182S:S:I160 3.798518
183S:S:P162 5.9225405
184S:S:V167 3.36404
185S:S:V171 3.43406
186S:S:Q172 7.985487
187S:S:L174 3.8375405
188S:S:P181 4.6375418
189S:S:Q182 6.338588
190S:S:I183 4.3475417
191S:S:Y185 5.05167618
192S:S:S189 4.58487
193S:S:L192 6.4175487
194S:S:Y198 6.24505
195S:S:Y200 8.2517
196S:S:F201 6.57833688
197S:S:L202 3.63406
198S:S:S207 4.675487
199S:S:Q211 7.54459
200S:S:L216 5.14754426
201S:S:R221 6.6025455
202S:S:Y222 5.905458
203S:S:W224 6.9775409
204S:S:Y226 8.451676219
205S:S:H231 8.6525404
206S:S:Y236 2.98407
207S:S:M241 6.006504
208S:S:F244 4.74406
209S:S:L273 6.5675405
210S:S:L274 2.988336124
211S:S:R278 5.3454123
212S:S:C291 5.56254444
213S:S:V296 4.545404
214S:S:L300 3.624124
215S:S:M303 4.4054125
216S:S:L306 3.3654123
217S:S:S317 4.4575408
218S:S:W320 5.403758137
219S:S:V326 4.075134
220S:S:I327 3.944134
221S:S:Y330 5.2404
222S:S:E333 5.9565124
223S:S:F350 7.262518
224S:S:Y353 7.0075407
225S:S:F354 7.86516
226S:S:L355 8.3975413
227S:S:L357 6.305415
228S:S:N362 6.79514
229S:S:R364 9.65514
230S:S:N365 6.60667617
231S:S:W367 6.03833614
232S:S:F368 5.6375815
233S:S:F371 6.32616
234S:S:W372 8.78167618
235S:S:R375 9.17414
236S:S:F376 10.185417
237S:S:L380 5.68403
238S:S:L400 4.095417
239S:S:Y404 9.04515
240S:S:Q406 7.97333616
241S:S:D407 6.5575416
242S:S:M410 8.265417
243S:S:V413 3.0325418
244S:S:I414 5.025417
245S:S:Y418 6.694518
246S:S:M420 4.744515
247S:S:M427 5.8725405
248S:S:L438 4.236502
249S:S:C439 6.04405
250S:S:M442 6.14403
251S:S:L454 4.34417
252S:S:F469 4.14408
253S:S:D474 6.262587
254S:S:R478 12.034464
255S:S:Y479 6.90833658
256S:S:M482 4.645405
257S:S:Y494 8.534134
258S:S:W500 6.802556
259S:S:H501 7.27254465
260S:S:L505 6.7275455
261S:S:I507 6.5475456
262S:S:I512 5.902557
263S:S:V519 2.92405
264S:S:K534 8.094257
265S:S:R537 6.9375465
266S:S:K538 3.8945216
267S:S:C544 4.211676219
268S:S:W545 7.558567
269S:S:N553 3.9925408
270S:S:Y555 8.38333667
271S:S:F560 7.412563
272S:S:C562 5.81254259
273S:S:C565 6.8425469
274S:S:W569 10.5375405
275S:S:L575 6.8225405
276S:S:V610 3.9775477
277S:S:F614 5.55479
278S:S:V623 4.4425479
279S:S:E629 5.055406
280S:S:C631 4.6775479
281S:S:L635 4.2175479
282S:S:Y642 7.63408
283S:S:C644 3.8054486
284S:S:P645 2.325407
285S:S:T647 4.73405
286S:S:T653 3.11405
287S:S:Q660 4.8154108
288S:S:R661 6.6556108
289S:S:K678 5.7525479
290S:S:N680 3.765267
291S:S:R699 4.7225406
292S:S:I709 5.185407
293S:S:P730 3.005409
294S:S:Y736 6.332504
295S:S:Y743 7.42754107
296S:S:I745 5.314106
297S:S:Y759 10.5625408
298S:S:L763 7.06754269
299S:S:I764 2.3525408
300S:S:Y770 5.5154497
301S:S:W798 5.765409
302S:S:F801 4.802509
303S:S:Y805 8.7409
304S:S:Y810 7.6175407
305S:S:F831 4579
306S:S:I838 4.545408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:E117 S:S:L127 17.97192.65YesNo053
2S:S:F178 S:S:L127 18.12166.09NoNo063
3S:S:F178 S:S:I123 14.756720.09NoNo065
4R:R:F178 S:S:I120 1002.51YesNo066
5R:R:F178 R:R:I123 80.063515.07YesNo065
6R:R:I123 R:R:L175 85.07582.85NoYes058
7R:R:L175 R:R:V159 82.68884.47YesNo087
8R:R:F178 R:R:I180 82.41782.51YesYes067
9R:R:I180 R:R:L175 80.4422.85YesYes078
10R:R:D107 R:R:W367 16.9513.35NoYes294
11R:R:C109 R:R:D107 17.08144.67YesNo279
12R:R:C109 R:R:V114 17.3266.83YesYes273
13R:R:I105 R:R:W367 12.97954.7YesYes284
14R:R:L175 R:R:V171 82.81012.98YesYes086
15S:S:E121 S:S:I120 1002.73NoNo046
16S:S:Q118 S:S:R106 1008.18YesYes065
17S:S:E121 S:S:R106 1005.82NoYes045
18R:R:Q182 R:R:V159 82.40964.3YesNo087
19R:R:Q182 R:R:V171 82.09472.87YesYes2886
20R:R:F201 R:R:Q182 1007.03YesYes088
21R:R:F201 R:R:R203 1005.34YesYes089
22R:R:W500 R:R:Y479 1007.72YesYes068
23R:R:D217 R:R:W500 1006.7NoYes066
24R:R:D217 R:R:L505 1006.79NoYes065
25R:R:I507 R:R:L505 86.91262.85YesYes965
26R:R:L505 R:R:R221 77.75773.64YesNo955
27R:R:R221 R:R:Y222 77.70683.09NoYes958
28R:R:I507 R:R:Y222 77.83863.63YesYes968
29R:R:W224 R:R:Y222 10015.43YesYes098
30R:R:S522 R:R:W224 1003.71NoYes099
31R:R:S522 R:R:Y226 1002.54NoYes099
32R:R:C524 R:R:Y226 10013.44YesYes1899
33R:R:F368 R:R:W372 10.66046.01YesYes258
34R:R:C524 R:R:S525 1001.72YesYes1899
35R:R:S525 R:R:W545 1006.18YesNo097
36R:R:V535 R:R:W545 10019.61NoNo057
37R:R:P571 R:R:Y555 54.12994.17YesYes1577
38R:R:Q557 R:R:Y555 1006.76YesYes1567
39R:R:Q557 R:R:T561 1002.83YesNo065
40R:R:R537 R:R:T561 1003.88NoNo055
41R:R:F560 R:R:R537 1005.34NoNo035
42R:R:F560 R:R:V535 10015.73NoNo3735
43R:R:P571 R:R:W570 51.41996.76YesNo076
44R:R:C578 R:R:Y555 98.63634.03YesYes1597
45R:R:G568 R:R:Y736 98.18015.79NoYes054
46R:R:G568 R:R:W569 98.29565.63NoNo055
47R:R:C578 R:R:W569 98.52683.92YesNo095
48R:R:I581 R:R:W570 50.951115.27NoNo086
49R:R:I581 R:R:P582 50.361410.16NoNo083
50R:R:P582 R:R:V742 50.24268.84NoYes438
51R:R:V742 R:R:Y736 50.17756.31YesYes484
52R:R:R584 R:R:V742 1006.54YesYes468
53R:R:K651 R:R:R584 95.14783.71YesYes446
54R:R:K651 R:R:L744 47.53527.05YesNo047
55R:R:L734 R:R:L744 47.65365.54NoNo037
56R:R:L734 R:R:Y736 47.77167.03NoYes434
57R:R:C644 R:R:L663 13.80989.52NoNo065
58R:R:L648 R:R:L663 14.899311.07NoNo075
59R:R:L648 R:R:Q660 20.34532.66NoYes078
60R:R:P652 R:R:Q660 23.123911.05NoYes498
61R:R:K651 R:R:P652 1001.67YesNo449
62R:R:F831 R:R:M830 36.922.49YesNo098
63R:R:M830 R:R:T790 39.08957.53NoYes089
64R:R:M791 R:R:T790 52.11374.52YesYes099
65R:R:I764 R:R:M791 68.73542.92YesYes1789
66R:R:I764 R:R:W798 76.6923.52YesYes1789
67R:R:L757 R:R:W798 93.33077.97NoYes079
68R:R:L757 R:R:V664 1002.98NoNo078
69R:R:G665 R:R:V664 1001.84NoNo068
70R:R:G665 R:R:V721 1001.84NoNo067
71R:R:I725 R:R:V721 1003.07YesNo077
72R:R:I725 R:R:R661 56.793412.53YesYes478
73R:R:C657 R:R:R661 58.23264.18NoYes498
74R:R:C657 R:R:C746 1007.28NoYes499
75R:R:C746 R:R:P652 1003.77YesNo499
76R:R:I725 R:R:P730 56.78673.39YesYes479
77R:R:C657 R:R:P730 58.59423.77NoYes499
78R:R:F831 R:R:M835 13.03291.24YesNo097
79R:R:F614 R:R:M835 10.86111.24YesNo097
80R:R:C829 R:R:T790 12.30843.38NoYes069
81R:R:G641 R:R:S667 10.17733.71NoNo077
82R:R:C644 R:R:S667 10.54066.89NoNo067
83R:R:L757 R:R:S668 15.19343NoNo078
84R:R:N760 R:R:S668 14.47062.98YesNo088
85R:R:N760 R:R:W798 14.47064.52YesYes089
86R:R:A669 R:R:N760 18.823.13NoYes088
87R:R:A669 R:R:Q717 17.37233.03NoYes089
88R:R:C767 R:R:M791 15.20678.1NoYes099
89R:R:A771 R:R:T774 12.31035.03NoYes098
90R:R:A771 R:R:C767 13.03431.81NoNo099
91R:R:L720 R:R:Q717 11.58172.66NoYes3879
92R:R:L720 R:R:P756 10.13413.28NoNo078
93S:S:D107 S:S:Q118 1003.92YesYes196
94S:S:D107 S:S:W367 1003.35YesYes194
95S:S:F178 S:S:I180 32.22772.51NoNo067
96S:S:I180 S:S:P181 20.77823.39NoYes078
97S:S:L454 S:S:P181 20.04093.28YesYes178
98S:S:F51 S:S:I160 12.67842.51YesYes188
99S:S:F51 S:S:I105 1007.54YesYes188
100S:S:I180 S:S:L175 11.41024.28NoNo078
101S:S:L175 S:S:V159 11.31244.47NoNo087
102S:S:Q182 S:S:V159 11.21764.3YesNo087
103S:S:F51 S:S:Y185 1004.13YesYes188
104S:S:S186 S:S:Y185 1005.09NoYes058
105S:S:K409 S:S:S186 1007.65NoNo045
106S:S:F412 S:S:K409 1006.2NoNo074
107S:S:F412 S:S:V205 1007.87NoNo077
108S:S:P206 S:S:V205 1005.3NoNo077
109S:S:P206 S:S:Y479 1008.34NoYes578
110S:S:W500 S:S:Y479 1005.79YesYes568
111S:S:L505 S:S:W500 1005.69YesYes556
112S:S:L505 S:S:R221 74.41917.29YesYes555
113S:S:R221 S:S:Y222 74.26533.09YesYes558
114S:S:W224 S:S:Y222 1009.65YesYes098
115S:S:I507 S:S:L505 75.24057.14YesYes565
116S:S:I507 S:S:Y222 74.26524.84YesYes568
117S:S:V286 S:S:W224 47.82418.58NoYes089
118S:S:R521 S:S:W224 1006NoYes039
119S:S:R521 S:S:V523 1002.62NoNo035
120S:S:C544 S:S:V523 1003.42YesNo095
121S:S:V286 S:S:V519 47.60693.21NoYes085
122S:S:R285 S:S:V519 45.77435.23NoYes065
123S:S:F312 S:S:R285 45.44096.41NoNo076
124S:S:F312 S:S:V287 20.032.62NoNo077
125S:S:C289 S:S:V287 19.18891.71NoNo057
126S:S:F312 S:S:M303 25.24752.49NoYes075
127S:S:C289 S:S:V296 18.51931.71NoYes054
128S:S:L300 S:S:M303 19.20662.83YesYes1245
129S:S:L300 S:S:V296 18.54292.98YesYes044
130S:S:V296 S:S:W320 34.7049.81YesYes047
131S:S:T339 S:S:W320 15.5023.64NoYes077
132S:S:W320 S:S:Y494 16.1764.82YesYes1374
133S:S:M482 S:S:T339 14.82853.01YesNo057
134S:S:M482 S:S:Y494 14.82987.18YesYes054
135S:S:K341 S:S:M482 13.48125.76NoYes065
136S:S:D480 S:S:K341 12.80726.91NoNo076
137S:S:H496 S:S:M482 15.50332.63NoYes045
138S:S:D480 S:S:H496 12.80767.56NoNo074
139S:S:D480 S:S:Q343 24.266715.66NoNo074
140S:S:H501 S:S:Q343 13.48166.18YesNo054
141S:S:P476 S:S:R478 13.481710.09NoYes034
142S:S:C544 S:S:K538 98.19963.23YesYes2196
143S:S:I546 S:S:K538 97.73887.27NoYes076
144S:S:I536 S:S:I546 97.57584.42NoNo037
145S:S:I536 S:S:T548 97.41277.6NoNo034
146S:S:K534 S:S:T548 97.249710.51YesNo074
147S:S:C550 S:S:K534 95.08873.23NoYes2597
148S:S:C550 S:S:L575 94.92933.17NoYes095
149S:S:L575 S:S:Y555 93.79043.52YesYes057
150S:S:C578 S:S:Y555 86.24665.38NoYes697
151S:S:C578 S:S:W569 86.11372.61NoYes095
152S:S:W569 S:S:Y736 85.6346.75YesYes054
153S:S:L734 S:S:Y736 83.13958.21NoYes034
154S:S:L734 S:S:L744 82.97552.77NoNo037
155S:S:L744 S:S:P652 82.83828.21NoNo079
156S:S:P652 S:S:P732 82.72421.95NoNo096
157S:S:M731 S:S:P732 82.563.35NoNo046
158S:S:M731 S:S:P729 82.39583.35NoNo048
159S:S:P729 S:S:P730 82.23161.95NoYes089
160S:S:P730 S:S:R661 79.43842.88YesYes098
161S:S:Q660 S:S:R661 30.10769.35YesYes1088
162S:S:L648 S:S:Q660 29.94453.99NoYes078
163S:S:R661 S:S:T748 24.922611.64YesNo1086
164S:S:L648 S:S:T815 22.61885.9NoNo078
165S:S:F801 S:S:T815 22.45216.49YesNo098
166S:S:A818 S:S:F801 64.28072.77NoYes089
167S:S:A818 S:S:W798 63.77932.59NoYes089
168S:S:W798 S:S:Y672 62.274910.61YesNo097
169S:S:L675 S:S:Y672 61.27195.86NoNo077
170S:S:L675 S:S:T679 60.77042.95NoNo079
171S:S:I787 S:S:T679 33.67134.56NoNo099
172S:S:I787 S:S:M830 33.16915.83NoNo098
173S:S:F831 S:S:M830 22.62092.49YesNo098
174S:S:R661 S:S:V664 23.416911.77YesNo1088
175S:S:V664 S:S:V753 23.25133.21NoNo087
176S:S:V753 S:S:Y805 22.75137.57NoYes079
177S:S:F801 S:S:Y805 44.83818.25YesYes099
178S:S:K811 S:S:T748 22.91594.5NoNo1086
179S:S:K811 S:S:Y805 22.754614.33NoYes089
180S:S:F831 S:S:I634 13.07176.28YesNo798
181S:S:I634 S:S:K678 12.570811.63NoYes789
182S:S:M830 S:S:T790 10.05676.02NoNo089
183S:S:C767 S:S:T679 26.63998.45NoNo099
184S:S:C767 S:S:S766 22.11851.72NoNo094
185S:S:N680 S:S:S766 21.61612.98YesNo074
186R:R:R203 R:R:V205 1003.92YesNo097
187R:R:P206 R:R:Y479 1009.74NoYes3478
188R:R:P206 R:R:V205 1003.53NoNo077
189S:S:I105 S:S:W367 1004.7YesYes184
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7DGD
Class C
SubFamily Aminoacid
Type Metabotropic Glutamate
SubType mGlu1; mGlu1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.96
Date 2021-09-22
D.O.I. doi.org/10.1007/s13238-020-00808-5
Net Summary
Imin 2.49
Number of Linked Nodes 1505
Number of Links 1817
Number of Hubs 306
Number of Links mediated by Hubs 1074
Number of Communities 49
Number of Nodes involved in Communities 380
Number of Links involved in Communities 543
Path Summary
Number Of Nodes in MetaPath 190
Number Of Links MetaPath 189
Number of Shortest Paths 34231387
Length Of Smallest Path 3
Average Path Length 128
Length of Longest Path 124
Minimum Path Strength 1.24
Average Path Strength 8.00389
Maximum Path Strength 18.63
Minimum Path Correlation 0.73
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.85185
Average % Of Corr. Nodes 69.9445
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 64.9227
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• behavior   • multicellular organismal process   • locomotory behavior   • system process   • regulation of biological process   • nervous system process   • regulation of system process   • biological regulation   • sensory perception of pain   • regulation of nervous system process   • sensory perception   • regulation of sensory perception   • regulation of multicellular organismal process   • regulation of sensory perception of pain   • cellular response to stimulus   • positive regulation of cell communication   • regulation of cellular process   • positive regulation of signal transduction   • response to stimulus   • signaling   • positive regulation of biological process   • regulation of signal transduction   • intracellular signal transduction   • cell communication   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • intracellular signaling cassette   • signal transduction   • positive regulation of cellular process   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • MAPK cascade   • regulation of cell communication   • cellular process   • positive regulation of signaling   • L-glutamate import across plasma membrane   • import into cell   • organic anion transport   • nitrogen compound transport   • carboxylic acid transmembrane transport   • carboxylic acid transport   • transport   • import across plasma membrane   • amino acid transmembrane transport   • L-amino acid transport   • establishment of localization   • L-glutamate import   • transmembrane transport   • organic acid transport   • amino acid transport   • localization   • acidic amino acid transport   • dicarboxylic acid transport   • L-alpha-amino acid transmembrane transport   • amino acid import across plasma membrane   • L-glutamate transmembrane transport   • synaptic signaling   • cell-cell signaling   • synaptic signaling via neuropeptide   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • trans-synaptic signaling   • anterograde trans-synaptic signaling   • chemical synaptic transmission   • cell surface receptor signaling pathway   • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway   • glutamate receptor signaling pathway   • G protein-coupled glutamate receptor signaling pathway   • modulation of chemical synaptic transmission   • synaptic transmission, glutamatergic   • regulation of synaptic transmission, glutamatergic   • regulation of trans-synaptic signaling   • response to electrical stimulus   • cellular response to electrical stimulus   • response to abiotic stimulus   • cellular response to abiotic stimulus   • cellular response to environmental stimulus   • postsynaptic specialization membrane   • postsynaptic specialization   • synapse   • membrane   • plasma membrane   • postsynaptic density membrane   • synaptic membrane   • cell periphery   • postsynaptic density   • postsynapse   • cellular anatomical structure   • neuron to neuron synapse   • organelle   • cell junction
Gene OntologyCellular Component• postsynaptic specialization membrane   • postsynaptic specialization   • synapse   • membrane   • plasma membrane   • postsynaptic density membrane   • synaptic membrane   • cell periphery   • postsynaptic density   • postsynapse   • cellular anatomical structure   • neuron to neuron synapse   • organelle   • cell junction   • postsynaptic membrane   • asymmetric synapse   • plasma membrane region   • glutamatergic synapse   • G protein-coupled receptor homodimeric complex   • protein-containing complex   • plasma membrane protein complex   • membrane protein complex   • receptor complex   • G protein-coupled receptor dimeric complex   • plasma membrane signaling receptor complex   • G protein-coupled receptor complex   • dendrite terminus   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • dendriole   • plasma membrane bounded cell projection   • Schaffer collateral - CA1 synapse   • membrane-bounded organelle   • intracellular organelle   • intracellular anatomical structure   • nucleus   • intracellular membrane-bounded organelle
SCOP2Domain Identifier• G protein-coupled receptor-like   • Type 1 solute binding protein-like
SCOP2Family Identifier• G protein-coupled receptor-like   • Type 1 solute binding protein-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ13255
Sequence
>7DGD_Chain_R
QRSVARMDG DVIIGALFS VHHQPPAEK VPERKCGEI REQYGIQRV 
EAMFHTLDK INADPVLLP NITLGSEIR DSCWHSSVA LEQSIEFIR 
DSLISIRDT KKPIAGVIG PGSSSVAIQ VQNLLQLFD IPQIAYSAT 
SIDLSDKTL YKYFLRVVP SDTLQARAM LDIVKRYNW TYVSAVHTE 
GNYGESGMD AFKELAAQE GLCIAHSDK IYSNAGEKS FDRLLRKLR 
ERLPKARVV VCFCEGMTV RGLLSAMRR LGVVGEFSL IGSDGWADR 
DEVIEGYEV EANGGITIK LQSPEVRSF DDYFLKLRL DTNTRNPWF 
PEFWQHRFQ CRLPGHLLE NPNFKRICT GNESLEENY VQDSKMGFV 
INAIYAMAH GLQNMHHAL CPGHVGLCD AMKPIDGSK LLDFLIKSS 
FIGVSGEEV WFDEKGDAP GRYDIMNLQ YTEANRYDY VHVGTWHEG 
VLNIDDYKI QMNKSGVVR SVCSEPCLK GQIKVIRKG EVSCCWICT 
ACKENEYVQ DEFTCKACD LGWWPNADL TGCEPIPVR YLEWSNIES 
IIAIAFSCL GILVTLFVT LIFVLYRDT PVVKSSSRE LCYIILAGI 
FLGYVCPFT LIAKPTTTS CYLQRLLVG LSSAMCYSA LVTKTNRIA 
RILAGSKKK ICTRKPRFM SAWAQVIIA SILISVQLT LVVTLIIME 
PPMPILSYP SIKEVYLIC NTSNLGVVA PLGYNGLLI MSCTYYAFK 
TRNVPANFN EAKYIAFTM YTTCIIWLA FVPIYFGSN YKIITTCFA 
VSLSVTVAL GCMFTPKMY III


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ13255
Sequence
>7DGD_Chain_S
QRSVARMDG DVIIGALFS VHHQPPAEK VPERKCGEI REQYGIQRV 
EAMFHTLDK INADPVLLP NITLGSEIR DSCWHSSVA LEQSIEFIR 
DSLISIRDT KKPIAGVIG PGSSSVAIQ VQNLLQLFD IPQIAYSAT 
SIDLSDKTL YKYFLRVVP SDTLQARAM LDIVKRYNW TYVSAVHTE 
GNYGESGMD AFKELAAQE GLCIAHSDK IYSNAGEKS FDRLLRKLR 
ERLPKARVV VCFCEGMTV RGLLSAMRR LGVVGEFSL IGSDGWADR 
DEVIEGYEV EANGGITIK LQSPEVRSF DDYFLKLRL DTNTRNPWF 
PEFWQHRFQ CRLPGHLLE NPNFKRICT GNESLEENY VQDSKMGFV 
INAIYAMAH GLQNMHHAL CPGHVGLCD AMKPIDGSK LLDFLIKSS 
FIGVSGEEV WFDEKGDAP GRYDIMNLQ YTEANRYDY VHVGTWHEG 
VLNIDDYKI QMNKSGVVR SVCSEPCLK GQIKVIRKG EVSCCWICT 
ACKENEYVQ DEFTCKACD LGWWPNADL TGCEPIPVR YLEWSNIES 
IIAIAFSCL GILVTLFVT LIFVLYRDT PVVKSSSRE LCYIILAGI 
FLGYVCPFT LIAKPTTTS CYLQRLLVG LSSAMCYSA LVTKTNRIA 
RILAGSKKK ICTRKPRFM SAWAQVIIA SILISVQLT LVVTLIIME 
PPMPILSYP SIKEVYLIC NTSNLGVVA PLGYNGLLI MSCTYYAFK 
TRNVPANFN EAKYIAFTM YTTCIIWLA FVPIYFGSN YKIITTCFA 
VSLSVTVAL GCMFTPKMY III


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4OR2CAminoacidMetabotropic GlutamatemGlu1; mGlu1Homo sapiens-FITM-2.82014-03-19doi.org/10.1126/science.1249489
7DGDCAminoacidMetabotropic GlutamatemGlu1; mGlu1Homo sapiens---3.962021-09-22doi.org/10.1007/s13238-020-00808-5
7DGECAminoacidMetabotropic GlutamatemGlu1; mGlu1Homo sapiensQuisqualate--3.652021-09-22doi.org/10.1007/s13238-020-00808-5




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