psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L36	R:R:W33	5.69	No	Yes	0	2	4
2	R:R:H37	R:R:W33	5.29	No	Yes	0	5	4
3	R:R:L292	R:R:W33	6.83	No	Yes	0	1	4
4	R:R:Q295	R:R:W33	4.38	No	Yes	0	5	4
5	L:L:R2	R:R:W33	33.99	Yes	Yes	0	0	4
6	R:R:D34	R:R:R38	8.34	No	No	0	5	4
7	R:R:L35	R:R:R38	4.86	No	No	0	4	4
8	R:R:L35	R:R:V39	4.47	No	No	0	4	4
9	R:R:L36	R:R:L40	8.3	No	Yes	0	2	5
10	R:R:H37	R:R:Q100	11.13	No	No	0	5	3
11	R:R:F101	R:R:H37	4.53	Yes	No	0	5	5
12	R:R:F43	R:R:L40	3.65	No	Yes	0	6	5
13	R:R:I44	R:R:L40	4.28	Yes	Yes	1	7	5
14	R:R:F299	R:R:L40	3.65	Yes	Yes	1	5	5
15	R:R:I97	R:R:P41	6.77	No	No	0	4	5
16	R:R:P41	R:R:W98	21.62	No	No	0	5	3
17	R:R:F43	R:R:I47	8.79	No	No	0	6	7
18	R:R:I44	R:R:L90	5.71	Yes	No	0	7	7
19	R:R:F299	R:R:I44	16.33	Yes	Yes	1	5	7
20	R:R:C48	R:R:L90	4.76	No	No	0	6	7
21	R:R:C48	R:R:P91	3.77	No	No	0	6	8
22	R:R:F49	R:R:F50	5.36	No	No	0	5	6
23	R:R:G51	R:R:V87	3.68	No	No	0	8	5
24	R:R:A80	R:R:N55	4.69	No	Yes	0	9	9
25	R:R:D83	R:R:N55	6.73	Yes	Yes	1	9	9
26	R:R:N55	R:R:S305	5.96	Yes	No	1	9	8
27	R:R:N55	R:R:P309	8.15	Yes	No	0	9	9
28	R:R:L56	R:R:L84	4.15	No	No	0	4	7
29	R:R:F57	R:R:V61	6.55	Yes	No	2	6	7
30	R:R:F314	R:R:F57	4.29	Yes	Yes	2	7	6
31	R:R:F319	R:R:F57	4.29	Yes	Yes	2	9	6
32	R:R:F57	R:R:V323	3.93	Yes	No	2	6	7
33	R:R:F62	R:R:V58	3.93	Yes	Yes	0	7	8
34	R:R:V313	R:R:V58	8.02	No	Yes	2	7	8
35	R:R:F314	R:R:V58	3.93	Yes	Yes	2	7	8
36	R:R:F319	R:R:V61	9.18	Yes	No	2	9	7
37	R:R:V323	R:R:V61	4.81	No	No	2	7	7
38	R:R:E73	R:R:F62	15.16	Yes	Yes	0	8	7
39	R:R:F62	R:R:L76	4.87	Yes	No	0	7	8
40	R:R:F319	R:R:F62	4.29	Yes	Yes	0	9	7
41	R:R:L326	R:R:L64	4.15	No	No	0	6	4
42	R:R:Q68	R:R:R151	9.35	No	Yes	0	7	1
43	R:R:E73	R:R:L69	7.95	Yes	No	0	8	5
44	R:R:E73	R:R:N70	18.4	Yes	No	0	8	7
45	R:R:R150	R:R:V71	13.08	No	No	0	6	6
46	R:R:R151	R:R:V71	5.23	Yes	No	0	1	6
47	R:R:E73	R:R:K322	8.1	Yes	No	0	8	5
48	R:R:I74	R:R:R151	7.52	No	Yes	0	6	1
49	R:R:I131	R:R:Y75	3.63	No	Yes	0	9	7
50	R:R:D134	R:R:Y75	16.09	No	Yes	0	8	7
51	R:R:A154	R:R:Y75	6.67	No	Yes	0	7	7
52	R:R:C158	R:R:N78	11.02	No	No	0	7	9
53	R:R:N78	R:R:W162	6.78	No	No	0	9	9
54	R:R:L127	R:R:L79	4.15	No	No	0	7	9
55	R:R:L79	R:R:V128	4.47	No	No	0	9	8
56	R:R:L79	R:R:N308	5.49	No	Yes	0	9	9
57	R:R:N120	R:R:S82	5.96	Yes	No	0	8	8
58	R:R:I123	R:R:S82	6.19	No	No	0	7	8
59	R:R:D83	R:R:S124	7.36	Yes	No	0	9	9
60	R:R:D83	R:R:N304	4.04	Yes	Yes	1	9	9
61	R:R:D83	R:R:S305	8.83	Yes	No	1	9	8
62	R:R:D83	R:R:N308	4.04	Yes	Yes	1	9	9
63	R:R:N120	R:R:V85	10.35	Yes	No	0	8	7
64	R:R:F86	R:R:N120	3.62	No	Yes	0	7	8
65	R:R:F302	R:R:F86	16.08	Yes	No	1	7	7
66	L:L:F9	R:R:F86	4.29	Yes	No	1	0	7
67	R:R:S305	R:R:V87	6.46	No	No	0	8	5
68	R:R:F302	R:R:L90	17.05	Yes	No	0	7	7
69	R:R:F105	R:R:F92	12.86	Yes	No	0	7	6
70	R:R:F92	R:R:I113	11.3	No	No	0	6	5
71	R:R:N96	R:R:W93	7.91	Yes	Yes	1	5	6
72	R:R:N114	R:R:W93	10.17	No	Yes	1	5	6
73	R:R:F299	R:R:W93	6.01	Yes	Yes	1	5	6
74	L:L:P8	R:R:W93	22.97	Yes	Yes	1	0	6
75	R:R:F101	R:R:N96	3.62	Yes	Yes	0	5	5
76	R:R:N96	R:R:W103	9.04	Yes	Yes	1	5	9
77	R:R:N96	R:R:P104	4.89	Yes	Yes	1	5	2
78	R:R:F101	R:R:I97	8.79	Yes	No	0	5	4
79	R:R:F299	R:R:I97	3.77	Yes	No	0	5	4
80	R:R:N99	R:R:P104	4.89	No	Yes	0	4	2
81	L:L:F6	R:R:F101	19.29	No	Yes	0	0	5
82	R:R:I186	R:R:N102	7.08	No	No	0	2	4
83	R:R:N102	R:R:T187	7.31	No	No	0	4	4
84	R:R:P104	R:R:W103	4.05	Yes	Yes	1	2	9
85	R:R:F105	R:R:W103	13.03	Yes	Yes	1	7	9
86	R:R:C110	R:R:W103	5.22	No	Yes	1	9	9
87	R:R:C189	R:R:W103	11.75	Yes	Yes	1	9	9
88	R:R:F105	R:R:P104	5.78	Yes	Yes	1	7	2
89	R:R:F105	R:R:L109	6.09	Yes	No	0	7	6
90	R:R:I113	R:R:L109	4.28	No	No	0	5	6
91	R:R:C110	R:R:I178	4.91	No	No	0	9	6
92	R:R:C110	R:R:C189	7.28	No	Yes	1	9	9
93	R:R:N114	R:R:R176	24.1	No	Yes	1	5	6
94	R:R:C189	R:R:N114	4.72	Yes	No	1	9	5
95	R:R:G115	R:R:T172	3.64	No	No	0	6	4
96	R:R:F173	R:R:G115	9.03	No	No	0	5	6
97	R:R:F302	R:R:I117	5.02	Yes	No	0	7	6
98	R:R:F122	R:R:K118	6.2	Yes	Yes	0	7	5
99	R:R:K118	R:R:T172	7.51	Yes	No	0	5	4
100	R:R:K118	R:R:L206	8.46	Yes	Yes	0	5	5
101	L:L:F9	R:R:K118	4.96	Yes	Yes	0	0	5
102	R:R:F122	R:R:L121	4.87	Yes	No	0	7	7
103	L:L:F9	R:R:L121	7.31	Yes	No	0	0	7
104	R:R:F122	R:R:L168	8.53	Yes	No	0	7	5
105	R:R:I123	R:R:W162	15.27	No	No	0	7	9
106	R:R:F259	R:R:I125	6.28	Yes	No	1	9	8
107	R:R:I125	R:R:W263	15.27	No	Yes	1	8	8
108	R:R:V129	R:R:W126	8.58	No	No	0	7	5
109	R:R:L213	R:R:W126	6.83	No	No	0	5	5
110	R:R:P214	R:R:W126	8.11	No	No	0	9	5
111	R:R:I161	R:R:L127	4.28	No	No	0	7	7
112	R:R:V128	R:R:Y312	8.83	No	Yes	0	8	9
113	R:R:I131	R:R:R135	3.76	No	No	0	9	9
114	R:R:I131	R:R:Y312	4.84	No	Yes	0	9	9
115	R:R:I218	R:R:S132	6.19	No	No	1	8	9
116	R:R:N222	R:R:S132	5.96	Yes	No	1	8	9
117	R:R:F221	R:R:Q133	8.2	Yes	No	0	7	6
118	R:R:D134	R:R:V138	4.38	No	Yes	3	8	8
119	R:R:D134	R:R:R150	13.1	No	No	3	8	6
120	R:R:I225	R:R:R135	3.76	No	No	0	8	9
121	R:R:L255	R:R:R135	4.86	Yes	No	0	8	9
122	R:R:V140	R:R:Y136	8.83	No	Yes	4	7	8
123	R:R:H141	R:R:Y136	7.62	Yes	Yes	4	6	8
124	R:R:F221	R:R:Y136	12.38	Yes	Yes	0	7	8
125	R:R:H224	R:R:Y136	4.36	No	Yes	0	4	8
126	R:R:H141	R:R:R137	7.9	Yes	No	0	6	4
127	R:R:Q148	R:R:R137	7.01	No	No	0	4	4
128	R:R:S145	R:R:V138	4.85	No	Yes	0	6	8
129	R:R:R150	R:R:V138	6.54	No	Yes	3	6	8
130	R:R:H141	R:R:V140	6.92	Yes	No	4	6	7
131	R:R:S228	R:R:V140	6.46	No	No	0	5	7
132	R:R:Q148	R:R:Q153	5.12	No	No	0	4	3
133	R:R:R151	R:R:R155	9.6	Yes	No	0	1	3
134	R:R:F173	R:R:S169	6.61	No	No	0	5	7
135	R:R:L175	R:R:P194	6.57	Yes	No	5	5	5
136	R:R:L175	R:R:W198	6.83	Yes	No	5	5	3
137	R:R:C189	R:R:R176	5.57	Yes	Yes	1	9	6
138	R:R:L191	R:R:R176	9.72	Yes	Yes	1	4	6
139	L:L:G5	R:R:R176	4.5	No	Yes	1	0	6
140	R:R:I190	R:R:Q179	5.49	No	No	0	4	3
141	R:R:L192	R:R:Q179	6.65	No	No	0	4	3
142	R:R:L184	R:R:V181	4.47	No	Yes	0	3	1
143	L:L:P3	R:R:V181	7.07	No	Yes	0	0	1
144	R:R:I186	R:R:L184	4.28	No	No	0	2	3
145	L:L:R2	R:R:L184	13.36	Yes	No	0	0	3
146	L:L:P3	R:R:I190	8.47	No	No	0	0	4
147	R:R:L191	R:R:L193	4.15	Yes	Yes	0	4	6
148	R:R:L191	R:R:R202	6.07	Yes	No	0	4	5
149	L:L:G5	R:R:L191	5.13	No	Yes	1	0	4
150	R:R:H199	R:R:L193	5.14	No	Yes	0	4	6
151	R:R:P194	R:R:W198	5.4	No	No	5	5	3
152	R:R:E196	R:R:H195	3.69	No	No	0	1	4
153	R:R:A197	R:R:H195	4.39	No	No	0	3	4
154	R:R:E196	R:R:H199	3.69	No	No	0	1	4
155	R:R:H199	R:R:Q277	19.78	No	No	0	4	3
156	R:R:F200	R:R:F274	9.65	No	No	0	1	5
157	R:R:L206	R:R:R202	3.64	Yes	No	0	5	5
158	R:R:I203	R:R:N207	8.5	No	No	0	4	6
159	R:R:F274	R:R:I203	18.84	No	No	0	5	4
160	R:R:L206	R:R:Y266	4.69	Yes	Yes	1	5	7
161	R:R:H267	R:R:L206	3.86	Yes	Yes	1	8	5
162	R:R:H267	R:R:N207	10.2	Yes	No	0	8	6
163	R:R:F271	R:R:N207	3.62	No	No	0	6	6
164	R:R:F211	R:R:L212	3.65	Yes	No	0	8	4
165	R:R:F211	R:R:L215	3.65	Yes	Yes	0	8	6
166	R:R:F211	R:R:H267	13.58	Yes	Yes	0	8	8
167	R:R:F259	R:R:L215	4.87	Yes	Yes	0	9	6
168	R:R:L215	R:R:L260	5.54	Yes	No	0	6	5
169	R:R:I218	R:R:N222	4.25	No	Yes	1	8	8
170	R:R:F259	R:R:I218	6.28	Yes	No	1	9	8
171	R:R:F220	R:R:F221	6.43	No	Yes	0	4	7
172	R:R:F220	R:R:H224	11.31	No	No	0	4	4
173	R:R:I252	R:R:N222	7.08	No	Yes	0	7	8
174	R:R:L255	R:R:N222	4.12	Yes	Yes	0	8	8
175	R:R:L226	R:R:T249	4.42	Yes	No	0	5	5
176	R:R:L229	R:R:T248	4.42	No	No	0	8	7
177	R:R:R232	R:R:S236	7.91	No	Yes	0	6	3
178	R:R:K247	R:R:L251	4.23	No	No	0	7	8
179	R:R:K247	R:R:R317	6.19	No	No	0	7	5
180	R:R:L251	R:R:V315	8.94	No	No	0	8	6
181	R:R:I311	R:R:T254	4.56	No	No	0	8	5
182	R:R:L255	R:R:Y312	12.89	Yes	Yes	0	8	9
183	R:R:F259	R:R:W263	8.02	Yes	Yes	1	9	8
184	R:R:C262	R:R:W263	5.22	No	Yes	1	8	8
185	R:R:C262	R:R:N304	6.3	No	Yes	1	8	9
186	R:R:H267	R:R:W263	5.29	Yes	Yes	1	8	8
187	R:R:N304	R:R:W263	13.56	Yes	Yes	1	9	8
188	R:R:H267	R:R:Y266	5.44	Yes	Yes	1	8	7
189	R:R:A270	R:R:Y266	4	No	Yes	0	5	7
190	R:R:L294	R:R:Y266	4.69	No	Yes	0	4	7
191	R:R:N298	R:R:Y266	10.47	Yes	Yes	1	6	7
192	L:L:F9	R:R:Y266	11.35	Yes	Yes	1	0	7
193	R:R:F268	R:R:L272	9.74	No	No	0	6	5
194	R:R:F269	R:R:F289	8.57	Yes	No	0	5	4
195	R:R:F269	R:R:G293	9.03	Yes	No	0	5	5
196	R:R:F271	R:R:L275	9.74	No	No	0	6	5
197	R:R:E273	R:R:L294	6.63	No	No	0	4	4
198	L:L:K1	R:R:E273	6.75	Yes	No	0	0	4
199	R:R:F274	R:R:V278	5.24	No	No	0	5	2
200	R:R:F276	R:R:I290	3.77	No	No	0	2	5
201	L:L:K1	R:R:F276	11.17	Yes	No	0	0	2
202	R:R:Q279	R:R:R282	4.67	No	No	0	2	1
203	R:R:V281	R:R:W286	9.81	No	No	0	1	2
204	R:R:F285	R:R:W286	5.01	No	No	0	2	2
205	L:L:K1	R:R:E287	4.05	Yes	No	0	0	1
206	L:L:K1	R:R:D291	16.59	Yes	No	0	0	4
207	L:L:R2	R:R:D291	10.72	Yes	No	0	0	4
208	L:L:F6	R:R:Q295	4.68	No	No	0	0	5
209	L:L:S7	R:R:Q295	5.78	No	No	0	0	5
210	R:R:F299	R:R:N298	3.62	Yes	Yes	1	5	6
211	R:R:F302	R:R:N298	4.83	Yes	Yes	1	7	6
212	L:L:S7	R:R:N298	7.45	No	Yes	0	0	6
213	L:L:P8	R:R:N298	16.29	Yes	Yes	1	0	6
214	L:L:F9	R:R:N298	21.75	Yes	Yes	1	0	6
215	L:L:P8	R:R:F299	10.11	Yes	Yes	1	0	5
216	R:R:F300	R:R:T303	6.49	No	No	0	7	5
217	L:L:P8	R:R:F302	4.33	Yes	Yes	1	0	7
218	L:L:F9	R:R:F302	9.65	Yes	Yes	1	0	7
219	R:R:N304	R:R:N308	13.62	Yes	Yes	1	9	9
220	R:R:N308	R:R:Y312	8.14	Yes	Yes	0	9	9
221	R:R:F314	R:R:V310	3.93	Yes	No	0	7	7
222	R:R:F314	R:R:V313	5.24	Yes	No	2	7	7
223	R:R:F319	R:R:V313	9.18	Yes	No	2	9	7
224	R:R:F314	R:R:F319	6.43	Yes	Yes	2	7	9
225	R:R:R317	R:R:R320	5.33	No	No	0	5	8
226	R:R:F319	R:R:V323	3.93	Yes	No	2	9	7
227	R:R:K328	R:R:W324	15.08	No	No	0	4	4
228	R:R:E325	R:R:L326	3.98	No	No	0	5	6
229	R:R:L326	R:R:Q329	13.31	No	No	0	6	4
230	L:L:F6	L:L:R2	17.1	No	Yes	0	0	0
231	R:R:P309	R:R:V58	3.53	No	Yes	0	9	8
232	R:R:G89	R:R:I117	3.53	No	No	0	6	6
233	R:R:G165	R:R:I123	3.53	No	No	0	8	7
234	R:R:P182	R:R:V181	3.53	No	Yes	0	2	1
235	R:R:Q149	R:R:R152	3.5	No	No	0	6	4
236	R:R:E233	R:R:R237	3.49	No	No	0	4	2
237	R:R:A119	R:R:S169	3.42	No	No	0	5	7
238	R:R:I125	R:R:P214	3.39	No	No	0	8	9
239	R:R:I170	R:R:P171	3.39	No	No	0	5	7
240	R:R:C262	R:R:T303	3.38	No	No	0	8	5
241	R:R:L64	R:R:P65	3.28	No	No	0	4	5
242	L:L:P4	R:R:L193	3.28	No	Yes	0	0	6
243	R:R:A94	R:R:I44	3.25	No	Yes	0	7	7
244	R:R:A94	R:R:I45	3.25	No	No	0	7	4
245	R:R:A107	R:R:I178	3.25	No	No	0	3	6
246	R:R:V219	R:R:V256	3.21	No	No	0	5	8
247	R:R:C48	R:R:L52	3.17	No	No	0	6	6
248	R:R:A32	R:R:L292	3.15	No	No	0	5	1
249	R:R:A80	R:R:L59	3.15	No	No	0	9	7
250	R:R:A280	R:R:L275	3.15	No	No	0	3	5
251	R:R:C284	R:R:D288	3.11	No	No	0	6	3
252	R:R:I161	R:R:T157	3.04	No	No	0	7	5
253	R:R:C284	R:R:E287	3.04	No	No	0	6	1
254	R:R:F314	R:R:G54	3.01	Yes	No	0	7	7
255	R:R:F122	R:R:G210	3.01	Yes	No	0	7	6
256	R:R:L108	R:R:V112	2.98	No	No	0	2	5
257	R:R:L139	R:R:V138	2.98	No	Yes	0	8	8
258	R:R:L160	R:R:V164	2.98	No	No	0	3	4
259	R:R:L167	R:R:V163	2.98	No	No	0	5	4
260	R:R:L215	R:R:V219	2.98	Yes	No	0	6	5
261	R:R:L307	R:R:T303	2.95	No	No	0	7	5
262	R:R:F300	R:R:P265	2.89	No	No	0	7	9
263	R:R:I170	R:R:L174	2.85	No	No	0	5	4
264	R:R:I208	R:R:L212	2.85	No	No	0	4	4
265	R:R:I225	R:R:L229	2.85	No	No	0	8	8
266	R:R:I252	R:R:L226	2.85	No	Yes	0	7	5
267	R:R:I311	R:R:L255	2.85	No	Yes	0	8	8
268	R:R:I290	R:R:L272	2.85	No	No	0	5	5
269	R:R:G283	R:R:W286	2.81	No	No	0	5	2
270	R:R:L52	R:R:L84	2.77	No	No	0	6	7
271	R:R:A144	R:R:R137	2.77	No	No	0	4	4
272	R:R:L175	R:R:L193	2.77	Yes	Yes	0	5	6
273	R:R:A264	R:R:F211	2.77	No	Yes	0	6	8
274	R:R:A217	R:R:F221	2.77	No	Yes	0	7	7
275	R:R:L226	R:R:L253	2.77	Yes	No	0	5	4
276	R:R:A297	R:R:F269	2.77	No	Yes	0	7	5
277	R:R:L292	R:R:L296	2.77	No	No	0	1	5
278	L:L:F9	R:R:A301	2.77	Yes	No	0	0	8
279	R:R:P30	R:R:W33	2.7	No	Yes	0	4	4
280	R:R:E325	R:R:K322	2.7	No	No	0	5	5
281	R:R:A130	R:R:Y75	2.67	No	Yes	0	7	7
282	R:R:E205	R:R:L209	2.65	No	No	0	3	4
283	R:R:F50	R:R:S306	2.64	No	No	0	6	8
284	R:R:F221	R:R:S132	2.64	Yes	No	0	7	9
285	R:R:R239	R:R:S236	2.64	No	Yes	0	1	3
286	R:R:F300	R:R:V261	2.62	No	No	0	7	6
287	R:R:F276	R:R:V281	2.62	No	No	0	2	1
288	R:R:R239	R:R:T238	2.59	No	No	0	1	2
289	R:R:F269	R:R:L294	2.44	Yes	No	0	5	4
290	R:R:F289	R:R:L272	2.44	No	No	0	4	5
291	R:R:L226	R:R:R230	2.43	Yes	No	0	5	4
292	R:R:E95	R:R:F105	2.33	No	Yes	0	4	7
293	R:R:G165	R:R:G166	2.11	No	No	0	8	3
294	R:R:W324	R:R:Y327	1.93	No	No	0	4	5
295	R:R:G51	R:R:S306	1.86	No	No	0	8	8
296	R:R:G316	R:R:V315	1.84	No	No	0	8	6
297	R:R:G54	R:R:L53	1.71	No	No	0	7	4
298	R:R:C158	R:R:V159	1.71	No	No	0	7	2
299	R:R:G210	R:R:L209	1.71	No	No	0	6	4
300	R:R:A188	R:R:V181	1.7	No	Yes	0	4	1
301	R:R:S236	R:R:V235	1.62	Yes	No	0	3	2
302	R:R:A258	R:R:I311	1.62	No	No	0	7	8
303	R:R:D183	R:R:P182	1.61	No	No	0	1	2
304	R:R:V112	R:R:V116	1.6	No	No	0	5	4
305	R:R:V257	R:R:V261	1.6	No	No	0	4	6
306	R:R:A77	R:R:L59	1.58	No	No	0	5	7
307	R:R:A77	R:R:L63	1.58	No	No	0	5	4
308	R:R:I203	R:R:V204	1.54	No	No	0	4	4
309	R:R:H141	R:R:P142	1.53	Yes	No	0	6	8
310	R:R:F105	R:R:G106	1.51	Yes	No	0	7	8
311	R:R:L192	R:R:S177	1.5	No	No	0	4	4
312	R:R:G283	R:R:R282	1.5	No	No	0	5	1
313	R:R:L168	R:R:V164	1.49	No	No	0	5	4
314	R:R:N120	R:R:V116	1.48	Yes	No	0	8	4
315	R:R:L318	R:R:T321	1.47	No	No	0	6	5
316	R:R:E233	R:R:S236	1.44	No	Yes	0	4	3
317	R:R:A144	R:R:R147	1.38	No	No	0	4	4
318	R:R:L174	R:R:L175	1.38	No	Yes	0	4	5
319	R:R:L318	R:R:N70	1.37	No	No	0	6	7
320	R:R:F50	R:R:S46	1.32	No	No	0	6	4
321	R:R:R111	R:R:S177	1.32	No	No	0	6	4
322	R:R:R152	R:R:V156	1.31	No	No	0	4	3
323	R:R:A81	R:R:W162	1.3	No	No	0	5	9
324	R:R:A201	R:R:W198	1.3	No	No	0	3	3
325	R:R:T42	R:R:W98	1.21	No	No	0	5	3
326	R:R:Q149	R:R:R151	1.17	No	Yes	0	6	1
327	R:R:R66	R:R:R67	1.07	No	No	0	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:W33	9.81333	6	0	4
2	R:R:L40	4.97	4	1	5
3	R:R:I44	7.3925	4	1	7
4	R:R:N55	6.3825	4	1	9
5	R:R:F57	4.765	4	2	6
6	R:R:V58	4.8525	4	2	8
7	R:R:F62	7.0625	4	0	7
8	R:R:E73	12.4025	4	0	8
9	R:R:Y75	7.265	4	0	7
10	R:R:D83	6.2	5	1	9
11	R:R:W93	11.765	4	1	6
12	R:R:N96	6.365	4	1	5
13	R:R:F101	9.0575	4	0	5
14	R:R:W103	8.618	5	1	9
15	R:R:P104	4.9025	4	1	2
16	R:R:F105	6.93333	6	1	7
17	R:R:K118	6.7825	4	0	5
18	R:R:N120	5.3525	4	0	8
19	R:R:F122	5.6525	4	0	7
20	R:R:Y136	8.2975	4	4	8
21	R:R:V138	4.6875	4	3	8
22	R:R:H141	5.9925	4	4	6
23	R:R:R151	6.574	5	0	1
24	R:R:L175	4.3875	4	5	5
25	R:R:R176	10.9725	4	1	6
26	R:R:V181	4.1925	4	0	1
27	R:R:C189	7.33	4	1	9
28	R:R:L191	6.2675	4	1	4
29	R:R:L193	3.835	4	0	6
30	R:R:L206	5.1625	4	1	5
31	R:R:F211	5.9125	4	0	8
32	R:R:L215	4.26	4	0	6
33	R:R:F221	6.484	5	0	7
34	R:R:N222	5.3525	4	1	8
35	R:R:L226	3.1175	4	0	5
36	R:R:S236	3.4025	4	0	3
37	R:R:L255	6.18	4	0	8
38	R:R:F259	6.3625	4	1	9
39	R:R:W263	9.472	5	1	8
40	R:R:Y266	6.77333	6	1	7
41	R:R:H267	7.674	5	1	8
42	R:R:F269	5.7025	4	0	5
43	R:R:N298	10.735	6	1	6
44	R:R:F299	7.24833	6	1	5
45	R:R:F302	9.49333	6	1	7
46	R:R:N304	9.38	4	1	9
47	R:R:N308	7.8225	4	1	9
48	R:R:Y312	8.675	4	0	9
49	R:R:F314	4.47167	6	2	7
50	R:R:F319	6.21667	6	2	9
51	L:L:K1	9.64	4	0	0
52	L:L:R2	18.7925	4	0	0
53	L:L:P8	13.425	4	1	0
54	L:L:F9	8.86857	7	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q295	R:R:W33	16.1848	4.38	No	Yes	0	5	4
2	L:L:R2	R:R:W33	12.8098	33.99	Yes	Yes	0	0	4
3	R:R:D83	R:R:N304	41.1991	4.04	Yes	Yes	1	9	9
4	R:R:N304	R:R:W263	70.258	13.56	Yes	Yes	1	9	8
5	R:R:H267	R:R:W263	100	5.29	Yes	Yes	1	8	8
6	R:R:H267	R:R:Y266	85.3979	5.44	Yes	Yes	1	8	7
7	R:R:N298	R:R:Y266	57.8066	10.47	Yes	Yes	1	6	7
8	R:R:F299	R:R:N298	23.4148	3.62	Yes	Yes	1	5	6
9	R:R:D83	R:R:N55	40.533	6.73	Yes	Yes	1	9	9
10	R:R:N55	R:R:P309	36.2517	8.15	Yes	No	0	9	9
11	R:R:F314	R:R:V58	11.6364	3.93	Yes	Yes	2	7	8
12	R:R:P309	R:R:V58	35.2	3.53	No	Yes	0	9	8
13	R:R:F62	R:R:V58	18.3085	3.93	Yes	Yes	0	7	8
14	R:R:E73	R:R:F62	13.0973	15.16	Yes	Yes	0	8	7
15	R:R:N304	R:R:N308	30.4217	13.62	Yes	Yes	1	9	9
16	R:R:N308	R:R:Y312	34.3817	8.14	Yes	Yes	0	9	9
17	R:R:I131	R:R:Y312	23.1375	4.84	No	Yes	0	9	9
18	R:R:I131	R:R:Y75	20.2327	3.63	No	Yes	0	9	7
19	R:R:D134	R:R:Y75	16.5229	16.09	No	Yes	0	8	7
20	R:R:D134	R:R:R150	11.3929	13.1	No	No	3	8	6
21	R:R:R150	R:R:V71	10.3175	13.08	No	No	0	6	6
22	R:R:I123	R:R:S82	10.9533	6.19	No	No	0	7	8
23	R:R:N120	R:R:S82	12.2924	5.96	Yes	No	0	8	8
24	R:R:F86	R:R:N120	18.8867	3.62	No	Yes	0	7	8
25	R:R:F302	R:R:L90	10.4562	17.05	Yes	No	0	7	7
26	L:L:F9	R:R:F86	14.4026	4.29	Yes	No	1	0	7
27	L:L:F9	R:R:N298	10.3683	21.75	Yes	Yes	1	0	6
28	R:R:F105	R:R:W103	15.691	13.03	Yes	Yes	1	7	9
29	R:R:N96	R:R:W103	15.7282	9.04	Yes	Yes	1	5	9
30	R:R:N96	R:R:W93	28.8188	7.91	Yes	Yes	1	5	6
31	R:R:F299	R:R:W93	15.3427	6.01	Yes	Yes	1	5	6
32	R:R:F105	R:R:P104	11.3354	5.78	Yes	Yes	1	7	2
33	R:R:N96	R:R:P104	14.5345	4.89	Yes	Yes	1	5	2
34	L:L:F6	R:R:Q295	11.7176	4.68	No	No	0	0	5
35	L:L:F6	L:L:R2	15.8196	17.1	No	Yes	0	0	0
36	L:L:R2	R:R:L184	32.542	13.36	Yes	No	0	0	3
37	R:R:F259	R:R:W263	30.0058	8.02	Yes	Yes	1	9	8
38	R:R:F259	R:R:I218	30.0091	6.28	Yes	No	1	9	8
39	R:R:I218	R:R:N222	12.3296	4.25	No	Yes	1	8	8
40	R:R:L255	R:R:N222	14.8118	4.12	Yes	Yes	0	8	8
41	R:R:L255	R:R:Y312	14.034	12.89	Yes	Yes	0	8	9
42	R:R:I218	R:R:S132	16.9152	6.19	No	No	1	8	9
43	R:R:F221	R:R:S132	21.5549	2.64	Yes	No	0	7	9
44	R:R:F221	R:R:Y136	14.8862	12.38	Yes	Yes	0	7	8
45	R:R:L191	R:R:L193	16.993	4.15	Yes	Yes	0	4	6
46	R:R:L191	R:R:R176	12.9755	9.72	Yes	Yes	1	4	6
47	L:L:P3	R:R:I190	11.7818	8.47	No	No	0	0	4
48	L:L:P3	R:R:V181	14.1186	7.07	No	Yes	0	0	1
49	R:R:L184	R:R:V181	23.3979	4.47	No	Yes	0	3	1
50	R:R:L206	R:R:R202	22.6201	3.64	Yes	No	0	5	5
51	R:R:H267	R:R:N207	10.8316	10.2	Yes	No	0	8	6
52	R:R:L294	R:R:Y266	27.8448	4.69	No	Yes	0	4	7
53	L:L:K1	R:R:D291	12.0253	16.59	Yes	No	0	0	4
54	L:L:R2	R:R:D291	11.4842	10.72	Yes	No	0	0	4
55	L:L:K1	R:R:E273	19.2452	6.75	Yes	No	0	0	4
56	L:L:S7	R:R:Q295	28.3622	5.78	No	No	0	0	5
57	L:L:S7	R:R:N298	29.0724	7.45	No	Yes	0	0	6
58	L:L:P8	R:R:N298	13.5944	16.29	Yes	Yes	1	0	6
59	R:R:L191	R:R:R202	21.6631	6.07	Yes	No	0	4	5
60	R:R:E273	R:R:L294	20.0196	6.63	No	No	0	4	4
61	L:L:P8	R:R:W93	17.622	22.97	Yes	Yes	1	0	6
62	L:L:F9	R:R:Y266	18.9239	11.35	Yes	Yes	1	0	7
63	R:R:K118	R:R:L206	10.561	8.46	Yes	Yes	0	5	5
64	R:R:H267	R:R:L206	22.2617	3.86	Yes	Yes	1	8	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L36	R:R:W33	5.69	0	No	Yes	2	4	2	1
R:R:H37	R:R:W33	5.29	0	No	Yes	5	4	2	1
R:R:L292	R:R:W33	6.83	0	No	Yes	1	4	2	1
R:R:Q295	R:R:W33	4.38	0	No	Yes	5	4	1	1
L:L:R2	R:R:W33	33.99	0	Yes	Yes	0	4	0	1
R:R:L36	R:R:L40	8.3	0	No	Yes	2	5	2	2
R:R:F101	R:R:H37	4.53	0	Yes	No	5	5	1	2
R:R:I44	R:R:L40	4.28	1	Yes	Yes	7	5	2	2
R:R:F299	R:R:L40	3.65	1	Yes	Yes	5	5	1	2
R:R:I44	R:R:L90	5.71	1	Yes	No	7	7	2	2
R:R:F299	R:R:I44	16.33	1	Yes	Yes	5	7	1	2
R:R:F86	R:R:N120	3.62	1	No	Yes	7	8	1	2
R:R:F302	R:R:F86	16.08	1	Yes	No	7	7	1	1
L:L:F9	R:R:F86	4.29	1	Yes	No	0	7	0	1
R:R:F302	R:R:L90	17.05	1	Yes	No	7	7	1	2
R:R:N96	R:R:W93	7.91	1	Yes	Yes	5	6	2	1
R:R:N114	R:R:W93	10.17	1	No	Yes	5	6	2	1
R:R:F299	R:R:W93	6.01	1	Yes	Yes	5	6	1	1
L:L:P8	R:R:W93	22.97	1	Yes	Yes	0	6	0	1
R:R:F101	R:R:N96	3.62	0	Yes	Yes	5	5	1	2
R:R:F101	R:R:I97	8.79	0	Yes	No	5	4	1	2
R:R:F299	R:R:I97	3.77	1	Yes	No	5	4	1	2
L:L:F6	R:R:F101	19.29	0	No	Yes	0	5	0	1
R:R:N114	R:R:R176	24.1	1	No	Yes	5	6	2	1
R:R:C189	R:R:N114	4.72	1	Yes	No	9	5	2	2
R:R:F302	R:R:I117	5.02	1	Yes	No	7	6	1	2
R:R:F122	R:R:K118	6.2	0	Yes	Yes	7	5	2	1
R:R:K118	R:R:T172	7.51	0	Yes	No	5	4	1	2
R:R:K118	R:R:L206	8.46	0	Yes	Yes	5	5	1	2
L:L:F9	R:R:K118	4.96	1	Yes	Yes	0	5	0	1
R:R:F122	R:R:L121	4.87	0	Yes	No	7	7	2	1
L:L:F9	R:R:L121	7.31	1	Yes	No	0	7	0	1
R:R:C189	R:R:R176	5.57	1	Yes	Yes	9	6	2	1
R:R:L191	R:R:R176	9.72	1	Yes	Yes	4	6	1	1
L:L:G5	R:R:R176	4.5	1	No	Yes	0	6	0	1
R:R:I190	R:R:Q179	5.49	0	No	No	4	3	1	2
R:R:L184	R:R:V181	4.47	0	No	Yes	3	1	1	1
L:L:P3	R:R:V181	7.07	0	No	Yes	0	1	0	1
R:R:I186	R:R:L184	4.28	0	No	No	2	3	2	1
L:L:R2	R:R:L184	13.36	0	Yes	No	0	3	0	1
L:L:P3	R:R:I190	8.47	0	No	No	0	4	0	1
R:R:L191	R:R:L193	4.15	1	Yes	Yes	4	6	1	1
R:R:L191	R:R:R202	6.07	1	Yes	No	4	5	1	2
L:L:G5	R:R:L191	5.13	1	No	Yes	0	4	0	1
R:R:H199	R:R:L193	5.14	0	No	Yes	4	6	2	1
R:R:L206	R:R:R202	3.64	1	Yes	No	5	5	2	2
R:R:L206	R:R:Y266	4.69	1	Yes	Yes	5	7	2	1
R:R:H267	R:R:L206	3.86	1	Yes	Yes	8	5	2	2
R:R:H267	R:R:Y266	5.44	1	Yes	Yes	8	7	2	1
R:R:A270	R:R:Y266	4	0	No	Yes	5	7	2	1
R:R:L294	R:R:Y266	4.69	0	No	Yes	4	7	2	1
R:R:N298	R:R:Y266	10.47	1	Yes	Yes	6	7	1	1
L:L:F9	R:R:Y266	11.35	1	Yes	Yes	0	7	0	1
R:R:E273	R:R:L294	6.63	0	No	No	4	4	1	2
L:L:K1	R:R:E273	6.75	0	Yes	No	0	4	0	1
R:R:F276	R:R:I290	3.77	0	No	No	2	5	1	2
L:L:K1	R:R:F276	11.17	0	Yes	No	0	2	0	1
L:L:K1	R:R:E287	4.05	0	Yes	No	0	1	0	1
L:L:K1	R:R:D291	16.59	0	Yes	No	0	4	0	1
L:L:R2	R:R:D291	10.72	0	Yes	No	0	4	0	1
L:L:F6	R:R:Q295	4.68	0	No	No	0	5	0	1
L:L:S7	R:R:Q295	5.78	0	No	No	0	5	0	1
R:R:F299	R:R:N298	3.62	1	Yes	Yes	5	6	1	1
R:R:F302	R:R:N298	4.83	1	Yes	Yes	7	6	1	1
L:L:S7	R:R:N298	7.45	0	No	Yes	0	6	0	1
L:L:P8	R:R:N298	16.29	1	Yes	Yes	0	6	0	1
L:L:F9	R:R:N298	21.75	1	Yes	Yes	0	6	0	1
L:L:P8	R:R:F299	10.11	1	Yes	Yes	0	5	0	1
L:L:P8	R:R:F302	4.33	1	Yes	Yes	0	7	0	1
L:L:F9	R:R:F302	9.65	1	Yes	Yes	0	7	0	1
R:R:P182	R:R:V181	3.53	0	No	Yes	2	1	2	1
L:L:P4	R:R:L193	3.28	0	No	Yes	0	6	0	1
R:R:C284	R:R:E287	3.04	0	No	No	6	1	2	1
R:R:L175	R:R:L193	2.77	5	Yes	Yes	5	6	2	1
L:L:F9	R:R:A301	2.77	1	Yes	No	0	8	0	1
R:R:P30	R:R:W33	2.7	0	No	Yes	4	4	2	1
R:R:F276	R:R:V281	2.62	0	No	No	2	1	1	2
R:R:A188	R:R:V181	1.7	0	No	Yes	4	1	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EIB_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.62
Number of Linked Nodes	288
Number of Links	327
Number of Hubs	54
Number of Links mediated by Hubs	186
Number of Communities	5
Number of Nodes involved in Communities	50
Number of Links involved in Communities	73

Path Summary
Number Of Nodes in MetaPath	65
Number Of Links MetaPath	64
Number of Shortest Paths	59905
Length Of Smallest Path	3
Average Path Length	12.2254
Length of Longest Path	28
Minimum Path Strength	1.41
Average Path Strength	7.34399
Maximum Path Strength	22.355
Minimum Path Correlation	0.7
Average Path Correlation	0.931107
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	53.8083
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	57.4037
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • positive regulation of locomotion • regulation of biological process • regulation of cell motility • regulation of cellular process • regulation of leukocyte migration • positive regulation of biological process • positive regulation of leukocyte migration • positive regulation of cell migration • leukocyte migration • immune system process • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cellular process • regulation of immune system process • cell motility • positive regulation of immune system process • locomotion • positive regulation of cellular process • response to stimulus • response to mechanical stimulus • response to abiotic stimulus • response to external stimulus • regulation of calcium ion transport • regulation of localization • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • intracellular calcium ion homeostasis • negative regulation of biological process • calcium ion transport • localization • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation homeostasis • monoatomic cation transport • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • establishment of localization • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • cellular localization • inorganic ion homeostasis • transport • homeostatic process • monoatomic ion transmembrane transport • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • negative regulation of cellular process • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • intracellular chemical homeostasis • positive regulation of release of sequestered calcium ion into cytosol • regulation of metal ion transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • regulation of transport • sequestering of calcium ion • cellular homeostasis • positive regulation of transport • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • defense response • response to stress • inflammatory response • cellular response to stimulus • signaling • G protein-coupled receptor signaling pathway • signal transduction • cell communication • regulation of growth • regulation of cellular component organization • growth • negative regulation of cell growth • regulation of cell growth • cell growth • cellular component organization • negative regulation of growth • cellular component organization or biogenesis • biological process involved in interspecies interaction between organisms • response to lipid • response to other organism • response to oxygen-containing compound • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to chemical • response to external biotic stimulus • response to molecule of bacterial origin • multicellular organismal process • system process • circulatory system process • regulation of blood pressure • negative regulation of blood pressure • blood circulation • cell periphery • cellular anatomical structure • plasma membrane • membrane • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • organelle • endoplasmic reticulum • cytoplasm • intracellular membrane-bounded organelle • endomembrane system • protein binding • binding • signaling receptor binding • enzyme regulator activity • molecular function inhibitor activity • peptidase regulator activity • molecular function regulator activity • enzyme inhibitor activity • cysteine-type endopeptidase inhibitor activity • peptidase inhibitor activity • endopeptidase regulator activity • endopeptidase inhibitor activity • hormone activity • molecular function activator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • cation binding • transition metal ion binding • zinc ion binding • ion binding • metal ion binding • small molecule binding • heparin binding • glycosaminoglycan binding • carbohydrate derivative binding • sulfur compound binding • regulation of body fluid levels • wound healing • hemostasis • blood coagulation • coagulation • response to wounding • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • apoptotic process • programmed cell death • regulation of response to external stimulus • regulation of response to wounding • regulation of coagulation • regulation of response to stress • regulation of multicellular organismal process • regulation of hemostasis • negative regulation of response to stimulus • negative regulation of wound healing • regulation of blood coagulation • negative regulation of blood coagulation • negative regulation of response to wounding • negative regulation of hemostasis • negative regulation of coagulation • regulation of response to stimulus • negative regulation of response to external stimulus • regulation of wound healing • negative regulation of multicellular organismal process • negative regulation of proteolysis • regulation of protein metabolic process • negative regulation of metabolic process • primary metabolic process • regulation of macromolecule metabolic process • regulation of primary metabolic process • regulation of proteolysis • proteolysis • metabolic process • protein metabolic process • macromolecule metabolic process • regulation of metabolic process • negative regulation of protein metabolic process • negative regulation of macromolecule metabolic process • regulation of tube diameter • regulation of tube size • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • regulation of anatomical structure size • cell adhesion • regulation of cell adhesion • negative regulation of cell adhesion • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • blood microparticle • membrane-enclosed lumen • intracellular organelle lumen • endoplasmic reticulum lumen • organelle lumen • vesicle lumen • intracellular vesicle • cytoplasmic vesicle lumen • secretory granule lumen • cytoplasmic vesicle • secretory granule • secretory vesicle • platelet alpha granule • platelet alpha granule lumen • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to oxygen levels • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • cardiac muscle cell apoptotic process • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P46663
Sequence	>7EIB_nogp_Chain_R P E A W D L L H R V L P T F I I S I C F F G L L G N L F V L L V F L L P R R Q L N V A E I Y L A N L A A S D L V F V L G L P F W A E N I W N Q F N W P F G A L L C R V I N G V I K A N L F I S I W L V V A I S Q D R Y R V L V H P M A S R R Q Q R R R Q A R V T C V L I W V V G G L L S I P T F L L R S I Q A V P D L N I T A C I L L L P H E A W H F A R I V E L N I L G F L L P L A A I V F F N Y H I L A S L R T R E E V S R T R S K T T A L I L T L V V A F L V C W A P Y H F F A F L E F L F Q V Q A V R G C F W E D F I D L G L Q L A N F F A F T N S S L N P V I Y V F V G R L F R T K V W E L Y K Q C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7EIB	A	Peptide	Bradykinin	BK₁	Homo sapiens	Des-Arg10-Kallidin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3	2021-10-13	doi.org/10.1038/s41594-021-00645-y
	7EIB (No Gprot)	A	Peptide	Bradykinin	BK₁	Homo sapiens	Des-Arg10-Kallidin	-		3	2021-10-13	doi.org/10.1038/s41594-021-00645-y

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