psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y112	23.5	Yes	Yes	1	0	4
2	L:L:?1	R:R:Y116	18.16	Yes	Yes	1	0	6
3	L:L:?1	R:R:Q162	7.28	Yes	No	0	0	5
4	L:L:?1	R:R:Y184	5.34	Yes	Yes	0	0	4
5	L:L:?1	R:R:A200	5.74	Yes	No	0	0	5
6	L:L:?1	R:R:Y260	12.82	Yes	Yes	1	0	6
7	L:L:?1	R:R:L290	3.78	Yes	Yes	1	0	5
8	L:L:?1	R:R:V294	4.07	Yes	No	0	0	5
9	R:R:A25	R:R:D22	6.18	No	No	0	2	3
10	R:R:L23	R:R:P185	3.28	No	No	0	4	5
11	R:R:Y24	R:R:Y90	8.94	No	No	3	2	5
12	R:R:T180	R:R:Y24	3.75	No	No	3	2	2
13	R:R:E183	R:R:Y24	6.73	Yes	No	3	4	2
14	R:R:H26	R:R:Q287	4.95	No	No	0	5	4
15	R:R:H26	R:R:I288	3.98	No	No	0	5	3
16	R:R:M34	R:R:V33	3.04	Yes	No	0	5	5
17	R:R:M34	R:R:Y91	5.99	Yes	No	4	5	5
18	R:R:H291	R:R:M34	13.13	No	Yes	4	4	5
19	R:R:I88	R:R:P35	3.39	No	No	0	7	4
20	R:R:H37	R:R:V41	6.92	No	Yes	0	5	7
21	R:R:C295	R:R:H37	10.32	No	No	0	5	5
22	R:R:F299	R:R:H37	4.53	No	No	0	5	5
23	R:R:L84	R:R:Y38	5.86	No	No	0	7	7
24	R:R:V294	R:R:Y38	3.79	No	No	0	5	7
25	R:R:N298	R:R:Y38	11.63	No	No	0	7	7
26	R:R:I44	R:R:L40	4.28	No	No	0	5	5
27	R:R:L84	R:R:V41	2.98	No	Yes	0	7	7
28	R:R:N298	R:R:V41	2.96	No	Yes	0	7	7
29	R:R:C302	R:R:V41	5.12	No	Yes	0	8	7
30	R:R:F42	R:R:L46	6.09	No	No	0	6	6
31	R:R:F42	R:R:P85	2.89	No	No	0	6	8
32	R:R:G48	R:R:P305	4.06	No	No	0	8	9
33	R:R:D77	R:R:N49	4.04	No	No	0	9	9
34	R:R:I78	R:R:N49	5.66	Yes	No	0	7	9
35	R:R:N49	R:R:P305	8.15	No	No	0	9	9
36	R:R:I78	R:R:L50	4.28	Yes	No	0	7	4
37	R:R:I78	R:R:L53	2.85	Yes	No	0	7	7
38	R:R:I56	R:R:T71	3.04	No	No	0	7	6
39	R:R:I56	R:R:Y308	8.46	No	No	0	7	9
40	R:R:K61	R:R:N59	6.99	No	No	0	6	5
41	R:R:K62	R:R:N59	5.6	No	No	0	6	5
42	R:R:N59	R:R:Y315	11.63	No	No	0	5	8
43	R:R:I63	R:R:R60	10.02	No	No	0	6	6
44	R:R:K62	R:R:N64	2.8	No	Yes	2	6	7
45	R:R:K62	R:R:T67	3	No	No	2	6	7
46	R:R:N64	R:R:T66	2.92	Yes	Yes	0	7	8
47	R:R:N64	R:R:T67	7.31	Yes	No	2	7	7
48	R:R:N64	R:R:Y139	3.49	Yes	Yes	2	7	6
49	R:R:S65	R:R:Y69	3.82	No	Yes	2	7	7
50	R:R:D128	R:R:S65	10.31	Yes	No	2	8	7
51	R:R:S65	R:R:Y139	3.82	No	Yes	2	7	6
52	R:R:L125	R:R:T66	4.42	No	Yes	0	9	8
53	R:R:D128	R:R:T66	7.23	Yes	Yes	0	8	8
54	R:R:L68	R:R:T71	2.95	No	No	0	6	6
55	R:R:K149	R:R:L68	4.23	No	No	0	3	6
56	R:R:C152	R:R:L68	3.17	No	No	0	8	6
57	R:R:L125	R:R:Y69	8.21	No	Yes	0	9	7
58	R:R:D128	R:R:Y69	8.05	Yes	Yes	2	8	7
59	R:R:V151	R:R:Y69	3.79	No	Yes	0	5	7
60	R:R:N72	R:R:T71	2.92	Yes	No	0	9	6
61	R:R:F121	R:R:N72	12.08	Yes	Yes	5	7	9
62	R:R:C152	R:R:N72	4.72	No	Yes	0	8	9
63	R:R:N72	R:R:W156	3.39	Yes	No	5	9	9
64	R:R:D304	R:R:L73	8.14	No	No	0	9	9
65	R:R:N114	R:R:S76	4.47	Yes	No	0	8	8
66	R:R:A117	R:R:S76	3.42	No	No	0	7	8
67	R:R:C301	R:R:D77	7.78	No	No	0	8	9
68	R:R:D304	R:R:D77	5.32	No	No	0	9	9
69	R:R:I78	R:R:T81	3.04	Yes	No	0	7	5
70	R:R:L79	R:R:N114	5.49	No	Yes	0	7	8
71	R:R:F80	R:R:L84	3.65	Yes	No	0	7	7
72	R:R:F111	R:R:F80	10.72	No	Yes	0	5	7
73	R:R:F80	R:R:N114	6.04	Yes	Yes	0	7	8
74	R:R:F80	R:R:T115	3.89	Yes	No	0	7	7
75	R:R:C301	R:R:F80	2.79	No	Yes	0	8	7
76	R:R:A83	R:R:V110	5.09	No	No	0	6	5
77	R:R:T107	R:R:T86	7.85	No	No	0	5	6
78	R:R:F111	R:R:R87	3.21	No	No	1	5	6
79	R:R:R87	R:R:Y112	3.09	No	Yes	1	6	4
80	R:R:M182	R:R:R87	12.41	No	No	0	4	6
81	R:R:I88	R:R:Y91	6.04	No	No	0	7	5
82	R:R:T180	R:R:Y90	11.24	No	No	3	2	5
83	R:R:H291	R:R:Y91	6.53	No	No	4	4	5
84	R:R:L103	R:R:T107	2.95	No	No	0	5	5
85	R:R:C104	R:R:C181	7.28	No	No	0	9	9
86	R:R:I106	R:R:R105	7.52	No	No	0	4	7
87	R:R:I106	R:R:L167	2.85	No	No	0	4	4
88	R:R:A108	R:R:L166	3.15	No	No	0	5	4
89	R:R:L109	R:R:T163	4.42	No	No	0	5	7
90	R:R:L109	R:R:L167	6.92	No	No	0	5	4
91	R:R:F111	R:R:Y112	16.5	No	Yes	1	5	4
92	R:R:Y112	R:R:Y260	4.96	Yes	Yes	1	4	6
93	R:R:I113	R:R:N114	4.25	No	Yes	0	4	8
94	R:R:I113	R:R:V159	6.14	No	No	0	4	8
95	R:R:I113	R:R:T163	3.04	No	No	0	4	7
96	R:R:T115	R:R:Y116	6.24	No	Yes	1	7	6
97	R:R:M297	R:R:T115	4.52	No	No	1	8	7
98	R:R:Y116	R:R:Y260	3.97	Yes	Yes	1	6	6
99	R:R:H261	R:R:Y116	8.71	Yes	Yes	1	8	6
100	R:R:M297	R:R:Y116	7.18	No	Yes	1	8	6
101	R:R:P208	R:R:V119	3.53	No	No	0	9	8
102	R:R:F257	R:R:V119	5.24	No	No	0	8	8
103	R:R:N120	R:R:V155	4.43	No	No	0	6	7
104	R:R:C124	R:R:F121	2.79	No	Yes	0	7	7
105	R:R:F121	R:R:V155	5.24	Yes	No	0	7	7
106	R:R:F121	R:R:W156	7.02	Yes	No	5	7	9
107	R:R:P208	R:R:T123	5.25	No	No	0	9	7
108	R:R:I211	R:R:T123	4.56	No	No	0	7	7
109	R:R:I212	R:R:T123	4.56	No	No	0	8	7
110	R:R:L125	R:R:R129	9.72	No	No	0	9	9
111	R:R:I212	R:R:S126	3.1	No	No	0	8	9
112	R:R:C215	R:R:S126	3.44	No	No	0	8	9
113	R:R:S126	R:R:Y216	5.09	No	Yes	0	9	9
114	R:R:I127	R:R:I211	2.94	No	No	0	7	7
115	R:R:C215	R:R:I127	3.27	No	No	0	8	7
116	R:R:D128	R:R:Y139	8.05	Yes	Yes	2	8	6
117	R:R:R129	R:R:Y216	7.2	No	Yes	0	9	9
118	R:R:F130	R:R:V134	6.55	Yes	Yes	7	8	7
119	R:R:F130	R:R:H135	5.66	Yes	No	7	8	6
120	R:R:C215	R:R:F130	6.98	No	Yes	0	8	8
121	R:R:F130	R:R:Q218	4.68	Yes	No	0	8	3
122	R:R:I131	R:R:Y139	3.63	No	Yes	2	5	6
123	R:R:I131	R:R:K143	13.09	No	No	2	5	6
124	R:R:A132	R:R:Y139	8.01	No	Yes	0	8	6
125	R:R:H135	R:R:V134	11.07	No	Yes	7	6	7
126	R:R:K222	R:R:V134	7.59	No	Yes	0	5	7
127	R:R:N140	R:R:Y139	3.49	No	Yes	0	5	6
128	R:R:K143	R:R:Y139	4.78	No	Yes	2	6	6
129	R:R:I142	R:R:K141	2.91	No	No	0	3	4
130	R:R:I142	R:R:K143	2.91	No	No	0	3	6
131	R:R:H147	R:R:I142	5.3	No	No	0	4	3
132	R:R:F154	R:R:L158	4.87	No	No	0	3	4
133	R:R:F160	R:R:W156	3.01	No	No	0	3	9
134	R:R:L166	R:R:T163	2.95	No	No	0	4	7
135	R:R:L164	R:R:P165	3.28	No	No	0	4	8
136	R:R:M171	R:R:M182	4.33	No	No	0	4	4
137	R:R:E183	R:R:T180	7.06	Yes	No	3	4	2
138	R:R:E183	R:R:P185	9.43	Yes	No	0	4	5
139	R:R:E183	R:R:N186	9.2	Yes	No	0	4	4
140	R:R:P185	R:R:Y184	5.56	No	Yes	0	5	4
141	R:R:E188	R:R:Y184	11.22	No	Yes	0	4	4
142	R:R:F286	R:R:Y184	5.16	No	Yes	0	4	4
143	R:R:E188	R:R:R283	4.65	No	Yes	0	4	4
144	R:R:P194	R:R:T190	3.5	No	No	0	3	2
145	R:R:K271	R:R:P194	6.69	No	No	0	3	3
146	R:R:I265	R:R:L198	4.28	No	No	0	6	5
147	R:R:C201	R:R:H261	7.37	No	Yes	0	5	8
148	R:R:C201	R:R:I265	3.27	No	No	0	5	6
149	R:R:F202	R:R:V206	7.87	No	No	0	4	5
150	R:R:L209	R:R:Y205	4.69	No	No	0	6	8
151	R:R:T258	R:R:Y205	8.74	No	No	0	6	8
152	R:R:H261	R:R:Y205	21.78	Yes	No	0	8	8
153	R:R:L207	R:R:P208	3.28	No	No	0	6	9
154	R:R:I211	R:R:L207	5.71	No	No	0	7	6
155	R:R:F253	R:R:L209	3.65	No	No	0	9	6
156	R:R:I210	R:R:I214	2.94	No	No	0	4	4
157	R:R:F253	R:R:I212	7.54	No	No	0	9	8
158	R:R:I246	R:R:Y216	8.46	No	Yes	6	8	9
159	R:R:I249	R:R:Y216	6.04	No	Yes	0	8	9
160	R:R:I250	R:R:Y216	7.25	No	Yes	6	8	9
161	R:R:C220	R:R:I246	3.27	No	No	0	5	8
162	R:R:F224	R:R:L243	3.65	No	No	0	3	6
163	R:R:T226	R:R:T233	4.71	No	No	0	6	4
164	R:R:N230	R:R:T233	5.85	No	No	0	4	4
165	R:R:N239	R:R:T233	2.92	No	No	0	7	4
166	R:R:K240	R:R:L243	2.82	No	No	0	4	6
167	R:R:K240	R:R:N244	6.99	No	No	0	4	6
168	R:R:K241	R:R:T245	4.5	No	No	0	7	8
169	R:R:K241	R:R:K313	2.87	No	No	0	7	5
170	R:R:I246	R:R:I250	2.94	No	No	6	8	8
171	R:R:I307	R:R:L248	2.85	No	No	0	8	5
172	R:R:I249	R:R:I307	2.94	No	No	0	8	8
173	R:R:M303	R:R:V252	6.09	No	No	0	6	7
174	R:R:I307	R:R:V252	3.07	No	No	0	8	7
175	R:R:F253	R:R:F257	8.57	No	No	0	9	8
176	R:R:T258	R:R:V254	4.76	No	No	0	6	7
177	R:R:C256	R:R:N300	3.15	No	No	0	8	9
178	R:R:F257	R:R:N300	8.46	No	No	0	8	9
179	R:R:P259	R:R:T293	6.99	No	No	0	9	7
180	R:R:H261	R:R:Y260	9.8	Yes	Yes	1	8	6
181	R:R:L290	R:R:Y260	4.69	Yes	Yes	1	5	6
182	R:R:T293	R:R:Y260	6.24	No	Yes	0	7	6
183	R:R:M297	R:R:Y260	13.17	No	Yes	1	8	6
184	R:R:I264	R:R:L290	4.28	No	Yes	0	5	5
185	R:R:K270	R:R:Q266	4.07	No	No	0	2	5
186	R:R:H267	R:R:M268	3.94	No	No	0	4	5
187	R:R:H267	R:R:R283	5.64	No	Yes	8	4	4
188	R:R:F286	R:R:H267	35.07	No	No	8	4	4
189	R:R:F277	R:R:K271	4.96	No	No	0	1	3
190	R:R:F274	R:R:N276	3.62	No	No	0	3	2
191	R:R:F277	R:R:R283	12.83	No	Yes	0	1	4
192	R:R:C280	R:R:L278	7.94	No	No	0	9	4
193	R:R:L278	R:R:Q282	3.99	No	No	0	4	1
194	R:R:E279	R:R:R283	25.59	No	Yes	0	5	4
195	R:R:Q282	R:R:S281	5.78	No	No	0	1	2
196	R:R:F286	R:R:R283	3.21	No	Yes	8	4	4
197	R:R:H284	R:R:I288	10.61	No	No	0	4	3
198	R:R:H291	R:R:Q287	4.95	No	No	0	4	4
199	R:R:C302	R:R:F299	12.57	No	No	0	8	5
200	R:R:F299	R:R:M303	3.73	No	No	0	5	6
201	R:R:D304	R:R:P305	4.83	No	No	0	9	9
202	R:R:F309	R:R:Y308	3.09	No	No	0	7	9
203	R:R:K313	R:R:K316	2.87	No	No	0	5	8
204	R:R:L46	R:R:L50	2.77	No	No	0	6	4
205	R:R:A52	R:R:F309	2.77	No	No	0	9	7
206	R:R:L209	R:R:L213	2.77	No	No	0	6	5
207	R:R:C124	R:R:Y69	2.69	No	Yes	0	7	7
208	R:R:C152	R:R:Y69	2.69	No	Yes	0	8	7
209	R:R:A148	R:R:Y69	2.67	No	Yes	0	7	7
210	R:R:F310	R:R:T245	2.59	No	No	0	7	8
211	R:R:H284	R:R:L23	2.57	No	No	0	4	4
212	L:L:?1	R:R:L197	2.52	Yes	No	0	0	5
213	R:R:F130	R:R:I219	2.51	Yes	No	0	8	8
214	R:R:F160	R:R:I157	2.51	No	No	0	3	4
215	R:R:F309	R:R:L51	2.44	No	No	0	7	6
216	R:R:F187	R:R:L193	2.44	No	No	0	2	3
217	R:R:F310	R:R:L248	2.44	No	No	0	7	5
218	R:R:L137	R:R:R138	2.43	No	No	0	6	5
219	R:R:L193	R:R:Y184	2.34	No	Yes	0	3	4
220	R:R:F306	R:R:F310	2.14	No	No	0	7	7
221	R:R:C301	R:R:G45	1.96	No	No	0	8	8
222	R:R:G48	R:R:V47	1.84	No	No	0	8	5
223	R:R:P170	R:R:S172	1.78	No	No	0	5	5
224	R:R:G204	R:R:I203	1.76	No	No	0	5	5
225	R:R:G314	R:R:K313	1.74	No	No	0	6	5
226	R:R:C221	R:R:S217	1.72	No	No	0	3	3
227	R:R:G118	R:R:L73	1.71	No	No	0	9	9
228	R:R:G199	R:R:L198	1.71	No	No	0	4	5
229	R:R:A263	R:R:S289	1.71	No	No	0	4	5
230	R:R:G237	R:R:N239	1.7	No	No	0	4	7
231	R:R:C104	R:R:T107	1.69	No	No	0	9	5
232	R:R:D101	R:R:G100	1.68	No	No	0	3	8
233	R:R:A311	R:R:T245	1.68	No	No	0	6	8
234	R:R:C302	R:R:I44	1.64	No	No	0	8	5
235	R:R:L296	R:R:P259	1.64	No	No	0	8	9
236	R:R:N140	R:R:P136	1.63	No	No	0	5	8
237	R:R:N169	R:R:P170	1.63	No	No	0	5	5
238	R:R:N230	R:R:P231	1.63	No	No	0	4	4
239	R:R:S236	R:R:V238	1.62	No	No	0	3	5
240	R:R:A30	R:R:M34	1.61	No	Yes	0	4	5
241	R:R:V54	R:R:V55	1.6	No	No	0	4	8
242	R:R:S70	R:R:T66	1.6	No	Yes	0	8	8
243	R:R:V133	R:R:V134	1.6	No	Yes	0	8	7
244	R:R:T29	R:R:V33	1.59	No	No	0	3	5
245	R:R:C220	R:R:L243	1.59	No	No	0	5	6
246	R:R:A242	R:R:L223	1.58	No	No	0	7	8
247	R:R:T81	R:R:T82	1.57	No	No	0	5	4
248	R:R:A83	R:R:N114	1.56	No	Yes	0	6	8
249	R:R:A227	R:R:N239	1.56	No	No	0	5	7
250	R:R:K191	R:R:S192	1.53	No	No	0	2	3
251	R:R:F202	R:R:G199	1.51	No	No	0	4	4
252	R:R:K222	R:R:T226	1.5	No	No	0	5	6
253	R:R:L290	R:R:S289	1.5	Yes	No	0	5	5
254	R:R:L51	R:R:V55	1.49	No	No	0	6	8
255	R:R:L53	R:R:V57	1.49	No	No	0	7	4
256	R:R:L53	R:R:V74	1.49	No	No	0	7	8
257	R:R:N186	R:R:S172	1.49	No	No	0	4	5
258	R:R:L248	R:R:V251	1.49	No	No	0	5	5
259	R:R:I43	R:R:I44	1.47	No	No	0	5	5
260	R:R:I153	R:R:I157	1.47	No	No	0	3	4
261	R:R:I265	R:R:I269	1.47	No	No	0	6	4
262	R:R:A25	R:R:H284	1.46	No	No	0	2	4
263	R:R:Q218	R:R:S217	1.44	No	No	0	3	3
264	R:R:I75	R:R:L79	1.43	No	No	0	6	7
265	R:R:I106	R:R:L103	1.43	No	No	0	4	5
266	R:R:I203	R:R:L207	1.43	No	No	0	5	6
267	R:R:I219	R:R:L223	1.43	No	No	0	8	8
268	R:R:L73	R:R:M122	1.41	No	No	0	9	8
269	R:R:K271	R:R:L272	1.41	No	No	0	3	2
270	R:R:L164	R:R:L167	1.38	No	No	0	4	4
271	R:R:D101	R:R:L103	1.36	No	No	0	3	5
272	R:R:C312	R:R:Y315	1.34	No	No	0	8	8
273	R:R:N230	R:R:Q229	1.32	No	No	0	4	3
274	R:R:H27	R:R:M93	1.31	No	No	0	3	5
275	R:R:F154	R:R:V151	1.31	No	No	0	3	5
276	R:R:F154	R:R:V155	1.31	No	No	0	3	7
277	R:R:I32	R:R:R31	1.25	No	No	0	5	4
278	R:R:I131	R:R:R138	1.25	No	No	0	5	5
279	R:R:Q229	R:R:R225	1.17	No	No	0	3	5
280	R:R:L198	R:R:W195	1.14	No	No	0	5	3
281	R:R:L272	R:R:W195	1.14	No	No	0	2	3
282	R:R:F274	R:R:R273	1.07	No	No	0	3	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.24555	9	1	0
2	R:R:M34	5.9425	4	4	5
3	R:R:V41	4.495	4	0	7
4	R:R:N64	4.13	4	2	7
5	R:R:T66	4.0425	4	0	8
6	R:R:Y69	4.56	7	2	7
7	R:R:N72	5.7775	4	5	9
8	R:R:I78	3.9575	4	0	7
9	R:R:F80	5.418	5	0	7
10	R:R:Y112	12.0125	4	1	4
11	R:R:N114	4.362	5	0	8
12	R:R:Y116	8.852	5	1	6
13	R:R:F121	6.7825	4	5	7
14	R:R:D128	8.41	4	2	8
15	R:R:F130	5.276	5	7	8
16	R:R:V134	6.7025	4	7	7
17	R:R:Y139	5.03857	7	2	6
18	R:R:E183	8.105	4	3	4
19	R:R:Y184	5.924	5	0	4
20	R:R:Y216	6.808	5	6	9
21	R:R:Y260	7.95	7	1	6
22	R:R:H261	11.915	4	1	8
23	R:R:R283	10.384	5	8	4
24	R:R:L290	3.5625	4	1	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y184	60.5751	5.34	Yes	Yes	0	0	4
2	R:R:P185	R:R:Y184	39.5398	5.56	No	Yes	0	5	4
3	R:R:L23	R:R:P185	24.2701	3.28	No	No	0	4	5
4	R:R:H284	R:R:L23	22.8059	2.57	No	No	0	4	4
5	R:R:E183	R:R:P185	14.5302	9.43	Yes	No	0	4	5
6	R:R:H284	R:R:I288	18.0155	10.61	No	No	0	4	3
7	R:R:H26	R:R:I288	16.4069	3.98	No	No	0	5	3
8	R:R:H26	R:R:Q287	14.7866	4.95	No	No	0	5	4
9	R:R:H291	R:R:Q287	13.1662	4.95	No	No	0	4	4
10	L:L:?1	R:R:V294	13.2899	4.07	Yes	No	0	0	5
11	R:R:V294	R:R:Y38	12.5681	3.79	No	No	0	5	7
12	R:R:L84	R:R:V41	45.8327	2.98	No	Yes	0	7	7
13	R:R:H37	R:R:V41	26.0113	6.92	No	Yes	0	5	7
14	R:R:F299	R:R:H37	25.6783	4.53	No	No	0	5	5
15	R:R:C302	R:R:V41	27.2663	5.12	No	Yes	0	8	7
16	R:R:C302	R:R:F299	26.6771	12.57	No	No	0	8	5
17	R:R:F111	R:R:F80	10.3468	10.72	No	Yes	0	5	7
18	R:R:C301	R:R:F80	40.7949	2.79	No	Yes	0	8	7
19	R:R:C301	R:R:D77	37.5247	7.78	No	No	0	8	9
20	R:R:D77	R:R:N49	24.0491	4.04	No	No	0	9	9
21	R:R:I78	R:R:N49	17.4381	5.66	Yes	No	0	7	9
22	L:L:?1	R:R:Y116	28.374	18.16	Yes	Yes	1	0	6
23	R:R:T115	R:R:Y116	34.7877	6.24	No	Yes	1	7	6
24	R:R:F80	R:R:T115	36.0074	3.89	Yes	No	0	7	7
25	R:R:D304	R:R:D77	12.0879	5.32	No	No	0	9	9
26	R:R:H261	R:R:Y116	46.6193	8.71	Yes	Yes	1	8	6
27	R:R:H261	R:R:Y205	75.8978	21.78	Yes	No	0	8	8
28	R:R:L209	R:R:Y205	75.7387	4.69	No	No	0	6	8
29	R:R:F253	R:R:L209	75.6209	3.65	No	No	0	9	6
30	R:R:F253	R:R:I212	73.102	7.54	No	No	0	9	8
31	R:R:I212	R:R:S126	71.7291	3.1	No	No	0	8	9
32	R:R:S126	R:R:Y216	69.8671	5.09	No	Yes	0	9	9
33	R:R:R129	R:R:Y216	100	7.2	No	Yes	0	9	9
34	R:R:L125	R:R:R129	99.2517	9.72	No	No	0	9	9
35	R:R:L125	R:R:Y69	66.2169	8.21	No	Yes	0	9	7
36	R:R:C152	R:R:Y69	28.7128	2.69	No	Yes	0	8	7
37	R:R:C152	R:R:L68	11.9966	3.17	No	No	0	8	6
38	L:L:?1	R:R:Y260	21.2739	12.82	Yes	Yes	1	0	6
39	R:R:H261	R:R:Y260	27.1573	9.8	Yes	Yes	1	8	6
40	R:R:C152	R:R:N72	15.6557	4.72	No	Yes	0	8	9
41	R:R:L125	R:R:T66	34.3193	4.42	No	Yes	0	9	8
42	R:R:N64	R:R:T66	20.3665	2.92	Yes	Yes	0	7	8
43	R:R:D128	R:R:T66	13.6611	7.23	Yes	Yes	0	8	8
44	R:R:D128	R:R:Y139	25.1805	8.05	Yes	Yes	2	8	6
45	R:R:D128	R:R:Y69	15.7205	8.05	Yes	Yes	2	8	7
46	R:R:S65	R:R:Y69	14.6186	3.82	No	Yes	2	7	7
47	R:R:F80	R:R:N114	42.4211	6.04	Yes	Yes	0	7	8
48	R:R:I113	R:R:N114	30.9136	4.25	No	Yes	0	4	8
49	R:R:I113	R:R:T163	27.5727	3.04	No	No	0	4	7
50	R:R:L109	R:R:T163	22.5172	4.42	No	No	0	5	7
51	R:R:L109	R:R:L167	20.8202	6.92	No	No	0	5	4
52	R:R:I106	R:R:L167	15.694	2.85	No	No	0	4	4
53	R:R:I106	R:R:L103	12.247	1.43	No	No	0	4	5
54	R:R:C215	R:R:S126	21.7747	3.44	No	No	0	8	9
55	R:R:C215	R:R:F130	19.0525	6.98	No	Yes	0	8	8
56	R:R:F130	R:R:V134	11.699	6.55	Yes	Yes	7	8	7
57	R:R:N64	R:R:Y139	13.3341	3.49	Yes	Yes	2	7	6
58	R:R:I131	R:R:Y139	13.3871	3.63	No	Yes	2	5	6
59	R:R:S65	R:R:Y139	13.5079	3.82	No	Yes	2	7	6
60	R:R:K143	R:R:Y139	17.8505	4.78	No	Yes	2	6	6
61	R:R:I142	R:R:K143	13.4225	2.91	No	No	0	3	6
62	R:R:F286	R:R:Y184	11.4633	5.16	No	Yes	0	4	4
63	R:R:I249	R:R:Y216	44.8811	6.04	No	Yes	0	8	9
64	R:R:F299	R:R:M303	51.5541	3.73	No	No	0	5	6
65	R:R:M303	R:R:V252	50.8087	6.09	No	No	0	6	7
66	R:R:I307	R:R:V252	50.1046	3.07	No	No	0	8	7
67	R:R:I307	R:R:L248	15.4318	2.85	No	No	0	8	5
68	R:R:F310	R:R:L248	12.3884	2.44	No	No	0	7	5
69	R:R:I56	R:R:T71	16.8135	3.04	No	No	0	7	6
70	R:R:I56	R:R:Y308	14.5302	8.46	No	No	0	7	9
71	R:R:F309	R:R:Y308	12.2647	3.09	No	No	0	7	9
72	R:R:F80	R:R:L84	39.3925	3.65	Yes	No	0	7	7
73	R:R:I249	R:R:I307	44.5629	2.94	No	No	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y112	23.5	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:Y116	18.16	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Q162	7.28	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y184	5.34	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:A200	5.74	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y260	12.82	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L290	3.78	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:V294	4.07	1	Yes	No	0	5	0	1
R:R:V294	R:R:Y38	3.79	0	No	No	5	7	1	2
R:R:F111	R:R:R87	3.21	1	No	No	5	6	2	2
R:R:R87	R:R:Y112	3.09	1	No	Yes	6	4	2	1
R:R:F111	R:R:Y112	16.5	1	No	Yes	5	4	2	1
R:R:Y112	R:R:Y260	4.96	1	Yes	Yes	4	6	1	1
R:R:T115	R:R:Y116	6.24	1	No	Yes	7	6	2	1
R:R:M297	R:R:T115	4.52	1	No	No	8	7	2	2
R:R:Y116	R:R:Y260	3.97	1	Yes	Yes	6	6	1	1
R:R:H261	R:R:Y116	8.71	1	Yes	Yes	8	6	2	1
R:R:M297	R:R:Y116	7.18	1	No	Yes	8	6	2	1
R:R:P185	R:R:Y184	5.56	0	No	Yes	5	4	2	1
R:R:E188	R:R:Y184	11.22	0	No	Yes	4	4	2	1
R:R:F286	R:R:Y184	5.16	8	No	Yes	4	4	2	1
R:R:H261	R:R:Y260	9.8	1	Yes	Yes	8	6	2	1
R:R:L290	R:R:Y260	4.69	1	Yes	Yes	5	6	1	1
R:R:T293	R:R:Y260	6.24	0	No	Yes	7	6	2	1
R:R:M297	R:R:Y260	13.17	1	No	Yes	8	6	2	1
R:R:I264	R:R:L290	4.28	0	No	Yes	5	5	2	1
L:L:?1	R:R:L197	2.52	1	Yes	No	0	5	0	1
R:R:L193	R:R:Y184	2.34	0	No	Yes	3	4	2	1
R:R:L290	R:R:S289	1.5	1	Yes	No	5	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7TUZ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.79
Number of Linked Nodes	258
Number of Links	282
Number of Hubs	24
Number of Links mediated by Hubs	99
Number of Communities	8
Number of Nodes involved in Communities	38
Number of Links involved in Communities	48

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	68777
Length Of Smallest Path	3
Average Path Length	15.6463
Length of Longest Path	32
Minimum Path Strength	1.14
Average Path Strength	5.97047
Maximum Path Strength	20
Minimum Path Correlation	0.7
Average Path Correlation	0.929576
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	42.2528
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	30.1032
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• multicellular organismal process • response to stimulus • cellular developmental process • cell development • mononuclear cell differentiation • mature B cell differentiation • B cell activation involved in immune response • lymphocyte activation • cell activation involved in immune response • lymphocyte differentiation • leukocyte activation • B cell differentiation • cell differentiation • leukocyte activation involved in immune response • anatomical structure development • lymphocyte activation involved in immune response • developmental process • mature B cell differentiation involved in immune response • immune response • hemopoiesis • B cell activation • cell activation • immune effector process • immune system process • cellular process • leukocyte differentiation • cell chemotaxis • cellular response to stimulus • chemotaxis • dendritic cell chemotaxis • response to external stimulus • leukocyte migration • dendritic cell migration • cellular response to chemical stimulus • taxis • response to chemical • mononuclear cell migration • cell migration • cell motility • leukocyte chemotaxis • locomotion • adaptive immune response • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • positive regulation of MAPK cascade • biological regulation • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • humoral immune response • myeloid leukocyte differentiation • myeloid cell differentiation • osteoclast differentiation • CD4-positive, alpha-beta T cell differentiation • CD4-positive, alpha-beta T cell differentiation involved in immune response • alpha-beta T cell differentiation involved in immune response • alpha-beta T cell differentiation • T cell activation involved in immune response • alpha-beta T cell activation involved in immune response • T cell activation • CD4-positive, alpha-beta T cell activation • alpha-beta T cell activation • T follicular helper cell differentiation • T cell differentiation • T-helper cell differentiation • T cell differentiation involved in immune response • G protein-coupled receptor signaling pathway • positive regulation of cell population proliferation • positive regulation of B cell proliferation • regulation of leukocyte activation • regulation of cell activation • leukocyte proliferation • positive regulation of lymphocyte activation • positive regulation of cell activation • regulation of B cell proliferation • lymphocyte proliferation • regulation of B cell activation • positive regulation of leukocyte activation • positive regulation of mononuclear cell proliferation • regulation of immune system process • regulation of multicellular organismal process • positive regulation of immune system process • regulation of lymphocyte proliferation • regulation of leukocyte proliferation • cell population proliferation • positive regulation of lymphocyte proliferation • B cell proliferation • positive regulation of B cell activation • regulation of cell population proliferation • mononuclear cell proliferation • positive regulation of leukocyte proliferation • regulation of mononuclear cell proliferation • positive regulation of multicellular organismal process • regulation of lymphocyte activation • regulation of cell motility • regulation of response to external stimulus • glial cell migration • regulation of glial cell migration • neurogenesis • multicellular organism development • astrocyte chemotaxis • gliogenesis • regulation of cell migration • astrocyte cell migration • system development • nervous system development • regulation of astrocyte chemotaxis • regulation of chemotaxis • regulation of locomotion • multicellular organismal-level homeostasis • leukocyte homeostasis • homeostatic process • homeostasis of number of cells • dendritic cell homeostasis • lymphocyte chemotaxis • lymphocyte migration • T cell chemotaxis • T cell migration • cell periphery • cellular anatomical structure • plasma membrane • membrane • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membrane-bounded organelle • intracellular organelle lumen • intracellular organelle • nucleoplasm • organelle lumen • organelle
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • plasma membrane • membrane • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membrane-bounded organelle • intracellular organelle lumen • intracellular organelle • nucleoplasm • organelle lumen • organelle • nuclear lumen • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • intracellular membraneless organelle • nucleolus • membraneless organelle • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	KJX
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	KJX
Name	(2S,4aS,4bS,7R,8S,8aS,9R,10aR)-7-[(2R,3R)-7-hydroxy-3,7-dimethyloctan-2-yl]-4a,7,8-trimethyltetradecahydrophenanthrene-2,9-diol
Synonyms
Identifier
Formula	C27 H46 O3
Molecular Weight	418.652
SMILES
PubChem	11954197
Formal Charge	0
Total Atoms	76
Total Chiral Atoms	9
Total Bonds	79
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32249
Sequence	>7TUZ_nogp_Chain_R D L Y A H H S T A R I V M P L H Y S L V F I I G L V G N L L A L V V I V Q N R K K I N S T T L Y S T N L V I S D I L F T T A L P T R I A Y Y A M G D A L C R I T A L V F Y I N T Y A G V N F M T C L S I D R F I A V V H P L R Y N K I K R I E H A K G V C I F V W I L V F A Q T L P L L I N P M S K I T C M E Y P N F E E T K S L P W I L L G A C F I G Y V L P L I I I L I C Y S Q I C C K L F R T A K Q N P L T E K S G V N K K A L N T I I L I I V V F V L C F T P Y H V A I I Q H M I K K L R F S N F L E C S Q R H S F Q I S L H F T V C L M N F N C C M D P F I Y F F A C K G Y K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7TUY	A	Orphan	Orphan	GPR183	Homo sapiens	GSK682753A	-	-	2.98	2022-04-13	10.1016/j.str.2022.04.006
	7TUZ	A	Orphan	Orphan	GPR183	Homo sapiens	7-α,25-dihydroxycholesterol	-	Gi1/β1/γ2	3.12	2022-04-13	10.1016/j.str.2022.04.006
	7TUZ (No Gprot)	A	Orphan	Orphan	GPR183	Homo sapiens	7-α,25-dihydroxycholesterol	-		3.12	2022-04-13	10.1016/j.str.2022.04.006

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