psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F2	L:L:L4	3.65	No	No	5	0	0
2	L:L:F2	R:R:H331	3.39	No	No	5	0	4
3	L:L:F3	L:L:F5	7.5	No	Yes	0	0	0
4	L:L:F3	R:R:N124	6.04	No	No	0	0	4
5	L:L:L4	R:R:H331	10.29	No	No	5	0	4
6	L:L:F5	R:R:M121	7.46	Yes	No	0	0	5
7	L:L:F5	R:R:Q335	4.68	Yes	No	0	0	2
8	L:L:F5	R:R:H338	15.84	Yes	No	0	0	4
9	L:L:R6	R:R:E120	12.79	No	No	0	0	5
10	L:L:R6	R:R:N124	4.82	No	No	0	0	4
11	L:L:P7	R:R:Y228	4.17	No	Yes	0	0	4
12	L:L:P7	R:R:W320	25.67	No	Yes	0	0	4
13	L:L:R8	R:R:E117	16.28	Yes	No	1	0	6
14	L:L:R8	R:R:F313	5.34	Yes	Yes	1	0	6
15	L:L:R8	R:R:D316	4.76	Yes	No	0	0	5
16	L:L:R8	R:R:H338	23.7	Yes	No	0	0	4
17	L:L:R8	R:R:G342	6	Yes	No	0	0	6
18	L:L:R8	R:R:Y346	4.12	Yes	Yes	1	0	7
19	L:L:N9	R:R:T138	10.24	No	No	0	0	5
20	L:L:N9	R:R:N196	8.17	No	No	0	0	4
21	L:L:N9	R:R:H200	22.96	No	No	0	0	4
22	R:R:C64	R:R:F60	8.38	No	No	0	6	3
23	R:R:M61	R:R:P62	3.35	No	No	0	5	3
24	R:R:I63	R:R:Y67	3.63	No	Yes	0	5	7
25	R:R:I63	R:R:M121	5.83	No	No	0	5	5
26	R:R:I63	R:R:V339	9.22	No	No	0	5	4
27	R:R:I343	R:R:T66	4.56	No	No	0	5	5
28	R:R:L114	R:R:Y67	7.03	Yes	Yes	1	7	7
29	R:R:E117	R:R:Y67	7.86	No	Yes	1	6	7
30	R:R:L118	R:R:Y67	8.21	No	Yes	0	6	7
31	R:R:Y346	R:R:Y67	6.95	Yes	Yes	1	7	7
32	R:R:F71	R:R:L114	10.96	No	Yes	0	6	7
33	R:R:G77	R:R:V76	3.68	No	No	0	8	4
34	R:R:D106	R:R:N78	6.73	Yes	Yes	0	9	9
35	R:R:L107	R:R:N78	5.49	No	Yes	0	7	9
36	R:R:N78	R:R:P353	14.66	Yes	No	0	9	9
37	R:R:S357	R:R:T81	7.99	Yes	No	0	7	9
38	R:R:C82	R:R:F100	11.17	No	Yes	0	8	6
39	R:R:L83	R:R:R87	15.79	No	No	0	4	5
40	R:R:M91	R:R:V84	4.56	Yes	No	0	8	8
41	R:R:F363	R:R:V84	9.18	No	No	0	8	8
42	R:R:I85	R:R:N96	4.25	No	No	0	7	9
43	R:R:F100	R:R:I85	7.54	Yes	No	0	6	7
44	R:R:L86	R:R:R92	4.86	No	No	0	4	7
45	R:R:F100	R:R:L86	4.87	Yes	No	0	6	4
46	R:R:H88	R:R:T366	12.32	No	No	0	6	6
47	R:R:M91	R:R:R362	7.44	Yes	Yes	0	8	6
48	R:R:M91	R:R:T366	7.53	Yes	No	0	8	6
49	R:R:R92	R:R:Y97	8.23	No	No	0	7	5
50	R:R:P94	R:R:T93	5.25	Yes	No	0	6	8
51	R:R:M172	R:R:P94	3.35	Yes	Yes	0	4	6
52	R:R:P94	R:R:V178	3.53	Yes	No	0	6	7
53	R:R:M172	R:R:T95	6.02	Yes	No	0	4	8
54	R:R:N96	R:R:R362	13.26	No	Yes	0	9	6
55	R:R:L155	R:R:Y98	5.86	No	Yes	0	9	8
56	R:R:E158	R:R:Y98	12.35	No	Yes	0	8	8
57	R:R:V178	R:R:Y98	10.09	No	Yes	0	7	8
58	R:R:V181	R:R:Y98	8.83	No	Yes	0	5	8
59	R:R:L182	R:R:Y98	3.52	No	Yes	0	7	8
60	R:R:L99	R:R:S357	4.5	No	Yes	0	8	7
61	R:R:F100	R:R:V104	3.93	Yes	No	0	6	7
62	R:R:N151	R:R:S101	10.43	No	No	7	8	9
63	R:R:L182	R:R:S101	4.5	No	No	0	7	9
64	R:R:S101	R:R:W186	6.18	No	No	7	9	9
65	R:R:L102	R:R:S105	4.5	Yes	No	3	9	8
66	R:R:D106	R:R:L102	8.14	Yes	Yes	3	9	9
67	R:R:L102	R:R:N352	4.12	Yes	No	3	9	9
68	R:R:L102	R:R:Y356	8.21	Yes	Yes	3	9	9
69	R:R:D106	R:R:S105	5.89	Yes	No	3	9	8
70	R:R:S105	R:R:S148	4.89	No	No	3	8	9
71	R:R:D106	R:R:S148	5.89	Yes	No	3	9	9
72	R:R:D106	R:R:N352	12.12	Yes	No	3	9	9
73	R:R:L107	R:R:L111	6.92	No	No	0	7	4
74	R:R:L108	R:R:V144	5.96	No	No	0	7	7
75	R:R:V109	R:R:V144	4.81	No	No	0	7	7
76	R:R:F345	R:R:V109	5.24	Yes	No	1	7	7
77	R:R:S349	R:R:V109	4.85	No	No	1	9	7
78	R:R:L140	R:R:V112	4.47	No	No	0	5	5
79	R:R:L114	R:R:P115	3.28	Yes	No	0	7	8
80	R:R:L114	R:R:Y346	4.69	Yes	Yes	1	7	7
81	R:R:E120	R:R:L116	5.3	No	No	0	5	6
82	R:R:L116	R:R:L129	4.15	No	No	0	6	7
83	R:R:L116	R:R:R137	13.36	No	No	0	6	5
84	R:R:E117	R:R:Y346	11.22	No	Yes	1	6	7
85	R:R:H123	R:R:Y119	10.89	No	No	0	5	4
86	R:R:L128	R:R:Y119	11.72	No	No	0	3	4
87	R:R:H123	R:R:W122	19.04	No	No	0	5	5
88	R:R:P214	R:R:Y125	4.17	No	No	0	2	3
89	R:R:V218	R:R:Y125	3.79	No	No	0	4	3
90	R:R:P126	R:R:S216	8.91	No	No	0	4	3
91	R:R:F127	R:R:L129	3.65	Yes	No	0	8	7
92	R:R:C134	R:R:F127	5.59	No	Yes	4	9	8
93	R:R:F127	R:R:I202	3.77	Yes	Yes	4	8	5
94	R:R:C219	R:R:F127	13.97	No	Yes	4	9	8
95	R:R:L128	R:R:L129	4.15	No	No	0	3	7
96	R:R:C134	R:R:I202	4.91	No	Yes	4	9	5
97	R:R:C134	R:R:C219	5.46	No	No	4	9	9
98	R:R:F136	R:R:L140	3.65	No	No	0	4	5
99	R:R:T138	R:R:T197	9.42	No	No	0	5	6
100	R:R:L139	R:R:S193	4.5	No	No	0	6	7
101	R:R:L139	R:R:T197	8.84	No	No	0	6	6
102	R:R:C145	R:R:F141	5.59	No	No	0	7	7
103	R:R:C145	R:R:E142	10.64	No	Yes	0	7	5
104	R:R:E142	R:R:L146	5.3	Yes	No	0	5	6
105	R:R:E142	R:R:F313	10.49	Yes	Yes	1	5	6
106	R:R:E142	R:R:R317	15.12	Yes	Yes	1	5	6
107	R:R:M143	R:R:M190	8.66	No	No	0	5	4
108	R:R:C145	R:R:W310	5.22	No	Yes	0	7	8
109	R:R:F239	R:R:L146	13.4	Yes	No	0	6	6
110	R:R:A147	R:R:W186	7.78	No	No	0	7	9
111	R:R:P243	R:R:V149	3.53	No	No	0	9	8
112	R:R:F306	R:R:V149	5.24	Yes	No	1	9	8
113	R:R:V149	R:R:W310	8.58	No	Yes	1	8	8
114	R:R:L150	R:R:V185	4.47	No	No	0	5	7
115	R:R:F239	R:R:L150	4.87	Yes	No	0	6	5
116	R:R:N151	R:R:V185	4.43	No	No	0	8	7
117	R:R:N151	R:R:W186	3.39	No	No	7	8	9
118	R:R:V152	R:R:Y356	7.57	No	Yes	0	9	9
119	R:R:P243	R:R:T153	3.5	No	No	0	9	7
120	R:R:I246	R:R:T153	4.56	No	No	0	7	7
121	R:R:L155	R:R:R159	3.64	No	No	0	9	9
122	R:R:M247	R:R:S156	4.6	No	No	8	8	9
123	R:R:L250	R:R:S156	4.5	No	No	0	7	9
124	R:R:S156	R:R:Y251	10.17	No	Yes	8	9	9
125	R:R:E158	R:R:H177	8.62	No	No	0	8	6
126	R:R:R159	R:R:Y356	7.2	No	Yes	0	9	9
127	R:R:V163	R:R:Y160	16.4	No	No	0	9	8
128	R:R:L250	R:R:Y160	7.03	No	No	0	7	8
129	R:R:L253	R:R:Y160	7.03	No	No	0	5	8
130	R:R:Q168	R:R:V161	10.03	No	No	0	5	4
131	R:R:R257	R:R:V163	6.54	No	No	0	5	9
132	R:R:L167	R:R:V164	5.96	No	No	0	7	7
133	R:R:H165	R:R:P166	21.35	No	No	0	6	8
134	R:R:L167	R:R:P166	3.28	No	No	0	7	8
135	R:R:L167	R:R:R170	6.07	No	No	0	7	5
136	R:R:M172	R:R:Q168	5.44	Yes	No	0	4	5
137	R:R:H177	R:R:V181	6.92	No	No	0	6	5
138	R:R:C192	R:R:F239	6.98	No	Yes	0	5	6
139	R:R:L194	R:R:P195	3.28	No	No	0	5	8
140	R:R:N196	R:R:V231	4.43	No	No	0	4	6
141	R:R:N196	R:R:R317	3.62	No	Yes	0	4	6
142	R:R:R223	R:R:S198	3.95	Yes	No	0	4	5
143	R:R:L199	R:R:R223	15.79	No	Yes	2	4	4
144	R:R:L199	R:R:L227	4.15	No	No	2	4	3
145	R:R:H200	R:R:L221	6.43	No	No	2	4	5
146	R:R:H200	R:R:Y228	6.53	No	Yes	2	4	4
147	R:R:C219	R:R:I202	3.27	No	Yes	4	9	5
148	R:R:L205	R:R:R203	8.5	No	No	0	3	3
149	R:R:M220	R:R:R203	12.41	No	No	0	4	3
150	R:R:H206	R:R:Q204	12.36	No	No	0	1	1
151	R:R:H206	R:R:P212	6.1	No	No	0	1	3
152	R:R:P208	R:R:V207	3.53	No	No	0	3	1
153	R:R:G211	R:R:P212	4.06	No	No	0	3	3
154	R:R:P212	R:R:P214	5.84	No	No	0	3	2
155	R:R:L221	R:R:Y228	19.93	No	Yes	2	5	4
156	R:R:L221	R:R:W320	7.97	No	Yes	0	5	4
157	R:R:P224	R:R:R223	4.32	No	Yes	2	4	4
158	R:R:L227	R:R:R223	4.86	No	Yes	2	3	4
159	R:R:L227	R:R:P224	3.28	No	No	2	3	4
160	R:R:R225	R:R:W320	16.99	No	Yes	0	4	4
161	R:R:V232	R:R:Y228	8.83	No	Yes	0	6	4
162	R:R:N229	R:R:Q233	15.85	No	No	0	3	5
163	R:R:N229	R:R:S321	8.94	No	Yes	0	3	4
164	R:R:R317	R:R:V232	3.92	Yes	No	0	6	6
165	R:R:S321	R:R:V232	3.23	Yes	No	0	4	6
166	R:R:F239	R:R:T235	5.19	Yes	No	0	6	5
167	R:R:R317	R:R:T235	5.17	Yes	No	0	6	5
168	R:R:A236	R:R:H314	4.39	No	Yes	0	6	7
169	R:R:F240	R:R:M244	4.98	Yes	No	1	8	6
170	R:R:F240	R:R:F306	4.29	Yes	Yes	1	8	9
171	R:R:F240	R:R:H314	5.66	Yes	Yes	1	8	7
172	R:R:L242	R:R:P243	3.28	No	No	0	5	9
173	R:R:I246	R:R:L242	4.28	No	No	0	7	5
174	R:R:F306	R:R:M244	3.73	Yes	No	1	9	6
175	R:R:M247	R:R:Y251	3.59	No	Yes	8	8	9
176	R:R:L299	R:R:Y251	15.24	No	Yes	0	8	9
177	R:R:L302	R:R:Y251	4.69	No	Yes	0	8	9
178	R:R:V303	R:R:Y251	3.79	No	Yes	0	8	9
179	R:R:F300	R:R:L252	7.31	No	No	0	6	4
180	R:R:R257	R:R:R260	4.26	No	No	0	5	4
181	R:R:M298	R:R:M359	7.22	No	No	0	9	7
182	R:R:L302	R:R:L355	5.54	No	No	0	8	8
183	R:R:L302	R:R:Y356	12.89	No	Yes	0	8	9
184	R:R:L355	R:R:V305	4.47	No	No	0	8	7
185	R:R:F306	R:R:W310	8.02	Yes	Yes	1	9	8
186	R:R:C309	R:R:G348	3.92	No	No	0	9	9
187	R:R:F313	R:R:W310	6.01	Yes	Yes	1	6	8
188	R:R:F345	R:R:W310	9.02	Yes	Yes	1	7	8
189	R:R:P312	R:R:S341	3.56	No	No	0	9	6
190	R:R:F344	R:R:P312	5.78	No	No	0	7	9
191	R:R:F313	R:R:H314	7.92	Yes	Yes	1	6	7
192	R:R:F313	R:R:R317	13.9	Yes	Yes	1	6	6
193	R:R:F313	R:R:F345	8.57	Yes	Yes	1	6	7
194	R:R:H314	R:R:R317	3.39	Yes	Yes	1	7	6
195	R:R:D316	R:R:V337	4.38	No	No	0	5	4
196	R:R:D316	R:R:S341	8.83	No	No	0	5	6
197	R:R:S321	R:R:V318	3.23	Yes	No	0	4	6
198	R:R:F334	R:R:M319	7.46	No	No	0	3	5
199	R:R:F334	R:R:W320	12.03	No	Yes	0	3	4
200	R:R:S321	R:R:V322	3.23	Yes	No	0	4	5
201	R:R:H331	R:R:V323	5.54	No	No	0	4	4
202	R:R:L332	R:R:Q335	3.99	No	No	0	1	2
203	R:R:H336	R:R:L332	5.14	No	No	0	3	1
204	R:R:F344	R:R:I340	3.77	No	No	0	7	5
205	R:R:F345	R:R:Y346	13.41	Yes	Yes	1	7	7
206	R:R:F345	R:R:S349	5.28	Yes	No	1	7	9
207	R:R:N352	R:R:Y356	6.98	No	Yes	3	9	9
208	R:R:L358	R:R:S357	4.5	No	Yes	0	6	7
209	R:R:F363	R:R:S357	5.28	No	Yes	0	8	7
210	R:R:F367	R:R:L358	3.65	No	No	0	6	6
211	R:R:R175	R:R:R179	3.2	No	No	0	3	2
212	R:R:C64	R:R:L118	3.17	No	No	0	6	6
213	R:R:C241	R:R:L237	3.17	No	No	0	4	4
214	R:R:A333	R:R:L330	3.15	No	No	0	4	1
215	R:R:A103	R:R:N78	3.13	No	Yes	0	9	9
216	R:R:I202	R:R:V131	3.07	Yes	No	0	5	4
217	R:R:M143	R:R:S193	3.07	No	No	0	5	7
218	R:R:M244	R:R:S248	3.07	No	No	0	6	4
219	R:R:I308	R:R:V304	3.07	No	No	0	6	5
220	R:R:M220	R:R:V218	3.04	No	No	0	4	4
221	R:R:M298	R:R:V301	3.04	No	No	0	9	6
222	R:R:M319	R:R:V323	3.04	No	No	0	5	4
223	R:R:F141	R:R:G113	3.01	No	No	0	7	6
224	R:R:F240	R:R:G307	3.01	Yes	No	1	8	6
225	R:R:F306	R:R:G307	3.01	Yes	No	1	9	6
226	R:R:L110	R:R:S349	3	No	No	0	7	9
227	R:R:L194	R:R:S198	3	No	No	0	5	5
228	R:R:L80	R:R:V76	2.98	No	No	0	6	4
229	R:R:L108	R:R:V104	2.98	No	No	0	7	7
230	R:R:L140	R:R:V144	2.98	No	No	0	5	7
231	R:R:L250	R:R:V157	2.98	No	No	0	7	6
232	R:R:L258	R:R:V295	2.98	No	No	0	9	8
233	R:R:L299	R:R:V295	2.98	No	No	0	8	8
234	R:R:L258	R:R:T296	2.95	No	No	0	9	7
235	R:R:G201	R:R:Y135	2.9	No	No	0	4	7
236	R:R:P94	R:R:R175	2.88	Yes	No	0	6	3
237	R:R:I254	R:R:L258	2.85	No	No	0	9	9
238	R:R:I254	R:R:L299	2.85	No	No	0	9	8
239	R:R:L330	R:R:M319	2.83	No	No	0	1	5
240	R:R:A311	R:R:F240	2.77	No	Yes	0	6	8
241	R:R:S216	R:R:Y125	2.54	No	No	0	3	3
242	R:R:V131	R:R:Y135	2.52	No	No	0	4	7
243	R:R:F344	R:R:I308	2.51	No	No	0	7	6
244	R:R:F239	R:R:L238	2.44	Yes	No	0	6	5
245	R:R:I70	R:R:Y346	2.42	No	Yes	0	8	7
246	R:R:L199	R:R:Y228	2.34	No	Yes	2	4	4
247	R:R:G132	R:R:G133	2.11	No	No	0	3	5
248	R:R:F300	R:R:Y251	2.06	No	Yes	0	6	9
249	R:R:G77	R:R:P353	2.03	No	No	0	8	9
250	R:R:A350	R:R:G74	1.95	No	No	0	7	8
251	R:R:A351	R:R:G348	1.95	No	No	0	6	9
252	R:R:G74	R:R:V73	1.84	No	No	0	8	5
253	R:R:G132	R:R:V131	1.84	No	No	0	3	4
254	R:R:G201	R:R:V222	1.84	No	No	0	4	3
255	R:R:G255	R:R:T296	1.82	No	No	0	6	7
256	R:R:A147	R:R:A189	1.79	No	No	0	7	8
257	R:R:P214	R:R:V213	1.77	No	No	0	2	7
258	R:R:G130	R:R:I202	1.76	No	Yes	0	8	5
259	R:R:G74	R:R:L110	1.71	No	No	0	8	7
260	R:R:C309	R:R:V305	1.71	No	No	0	9	7
261	R:R:A154	R:R:V185	1.7	No	No	0	7	7
262	R:R:A169	R:R:V173	1.7	No	No	0	6	6
263	R:R:A176	R:R:T174	1.68	No	No	0	4	7
264	R:R:S360	R:R:S361	1.63	No	No	6	8	4
265	R:R:A217	R:R:I202	1.62	No	Yes	0	4	5
266	R:R:A90	R:R:M91	1.61	No	Yes	0	5	8
267	R:R:V72	R:R:V73	1.6	No	No	0	5	5
268	R:R:V301	R:R:V305	1.6	No	No	0	6	7
269	R:R:C64	R:R:L68	1.59	No	No	0	6	3
270	R:R:M172	R:R:V173	1.52	Yes	No	0	4	6
271	R:R:A217	R:R:Q204	1.52	No	No	0	4	1
272	R:R:K297	R:R:V301	1.52	No	No	0	7	6
273	R:R:L69	R:R:V73	1.49	No	No	0	5	5
274	R:R:L253	R:R:V249	1.49	No	No	0	5	4
275	R:R:L358	R:R:V354	1.49	No	No	0	6	6
276	R:R:I343	R:R:I70	1.47	No	No	0	5	8
277	R:R:E365	R:R:S361	1.44	No	No	0	4	4
278	R:R:C241	R:R:F240	1.4	No	Yes	0	4	8
279	R:R:L150	R:R:L188	1.38	No	No	0	5	4
280	R:R:H177	R:R:T174	1.37	No	No	0	6	7
281	R:R:L59	R:R:Q335	1.33	No	No	0	3	2
282	R:R:R362	R:R:S360	1.32	Yes	No	6	6	8
283	R:R:F363	R:R:S360	1.32	No	No	0	8	8
284	R:R:R362	R:R:S361	1.32	Yes	No	6	6	4
285	R:R:R292	R:R:V295	1.31	No	No	0	7	8
286	R:R:R293	R:R:T296	1.29	No	No	0	5	7
287	R:R:F60	R:R:M61	1.24	No	No	0	3	5
288	R:R:H88	R:R:R87	1.13	No	No	0	6	5
289	R:R:F367	R:R:R364	1.07	No	No	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F5	8.87	4	0	0
2	L:L:R8	10.0333	6	1	0
3	R:R:Y67	6.736	5	1	7
4	R:R:N78	7.5025	4	0	9
5	R:R:M91	5.285	4	0	8
6	R:R:P94	3.7525	4	0	6
7	R:R:Y98	8.13	5	0	8
8	R:R:F100	6.8775	4	0	6
9	R:R:L102	6.2425	4	3	9
10	R:R:D106	7.754	5	3	9
11	R:R:L114	6.49	4	1	7
12	R:R:F127	6.745	4	4	8
13	R:R:E142	10.3875	4	1	5
14	R:R:M172	4.0825	4	0	4
15	R:R:I202	3.06667	6	4	5
16	R:R:R223	7.23	4	2	4
17	R:R:Y228	8.36	5	2	4
18	R:R:F239	6.576	5	0	6
19	R:R:F240	3.685	6	1	8
20	R:R:Y251	6.59	6	8	9
21	R:R:F306	4.858	5	1	9
22	R:R:W310	7.37	5	1	8
23	R:R:F313	8.705	6	1	6
24	R:R:H314	5.34	4	1	7
25	R:R:R317	7.52	6	1	6
26	R:R:W320	15.665	4	0	4
27	R:R:S321	4.6575	4	0	4
28	R:R:F345	8.304	5	1	7
29	R:R:Y346	7.135	6	1	7
30	R:R:Y356	8.57	5	3	9
31	R:R:S357	5.5675	4	0	7
32	R:R:R362	5.835	4	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F334	R:R:M319	11.4645	7.46	No	No	0	3	5
2	R:R:F334	R:R:W320	13.0794	12.03	No	Yes	0	3	4
3	R:R:V232	R:R:Y228	24.8523	8.83	No	Yes	0	6	4
4	R:R:R317	R:R:V232	28.8503	3.92	Yes	No	0	6	6
5	R:R:F313	R:R:R317	61.9664	13.9	Yes	Yes	1	6	6
6	L:L:R8	R:R:F313	67.396	5.34	Yes	Yes	1	0	6
7	L:L:R8	R:R:H338	46.341	23.7	Yes	No	0	0	4
8	L:L:F5	R:R:H338	45.3429	15.84	Yes	No	0	0	4
9	L:L:F3	L:L:F5	40.955	7.5	No	Yes	0	0	0
10	L:L:F3	R:R:N124	39.9162	6.04	No	No	0	0	4
11	L:L:R6	R:R:N124	38.8716	4.82	No	No	0	0	4
12	L:L:R6	R:R:E120	37.8212	12.79	No	No	0	0	5
13	L:L:R8	R:R:Y346	19.3209	4.12	Yes	Yes	1	0	7
14	R:R:F313	R:R:F345	48.1625	8.57	Yes	Yes	1	6	7
15	R:R:F345	R:R:Y346	21.0464	13.41	Yes	Yes	1	7	7
16	R:R:L118	R:R:Y67	15.5876	8.21	No	Yes	0	6	7
17	R:R:C64	R:R:L118	13.0038	3.17	No	No	0	6	6
18	R:R:Y346	R:R:Y67	15.3519	6.95	Yes	Yes	1	7	7
19	R:R:R317	R:R:T235	58.1284	5.17	Yes	No	0	6	5
20	R:R:F239	R:R:T235	57.8084	5.19	Yes	No	0	6	5
21	R:R:F239	R:R:L150	100	4.87	Yes	No	0	6	5
22	R:R:L150	R:R:V185	98.4054	4.47	No	No	0	5	7
23	R:R:N151	R:R:V185	96.7993	4.43	No	No	0	8	7
24	R:R:N151	R:R:S101	92.743	10.43	No	No	7	8	9
25	R:R:L182	R:R:S101	92.6528	4.5	No	No	0	7	9
26	R:R:L182	R:R:Y98	91.8061	3.52	No	Yes	0	7	8
27	R:R:L155	R:R:Y98	73.5997	5.86	No	Yes	0	9	8
28	R:R:L155	R:R:R159	72.6395	3.64	No	No	0	9	9
29	R:R:R159	R:R:Y356	71.6763	7.2	No	Yes	0	9	9
30	R:R:L102	R:R:Y356	16.4722	8.21	Yes	Yes	3	9	9
31	R:R:D106	R:R:L102	12.7128	8.14	Yes	Yes	3	9	9
32	R:R:D106	R:R:N78	20.412	6.73	Yes	Yes	0	9	9
33	R:R:N78	R:R:P353	10.2511	14.66	Yes	No	0	9	9
34	R:R:N352	R:R:Y356	13.9523	6.98	No	Yes	3	9	9
35	R:R:D106	R:R:N352	12.7157	12.12	Yes	No	3	9	9
36	R:R:F345	R:R:V109	37.8299	5.24	Yes	No	1	7	7
37	R:R:V109	R:R:V144	37.4283	4.81	No	No	0	7	7
38	R:R:L108	R:R:V144	33.0753	5.96	No	No	0	7	7
39	R:R:L108	R:R:V104	31.9725	2.98	No	No	0	7	7
40	R:R:F100	R:R:V104	30.8639	3.93	Yes	No	0	6	7
41	R:R:F100	R:R:I85	25.2335	7.54	Yes	No	0	6	7
42	R:R:I85	R:R:N96	24.09	4.25	No	No	0	7	9
43	R:R:N96	R:R:R362	22.9406	13.26	No	Yes	0	9	6
44	R:R:R362	R:R:S360	10.9087	1.32	Yes	No	6	6	8
45	R:R:V178	R:R:Y98	14.3073	10.09	No	Yes	0	7	8
46	R:R:P94	R:R:V178	13.0532	3.53	Yes	No	0	6	7
47	R:R:E120	R:R:L116	36.7649	5.3	No	No	0	5	6
48	R:R:L116	R:R:L129	34.6262	4.15	No	No	0	6	7
49	R:R:F127	R:R:L129	29.249	3.65	Yes	No	0	8	7
50	R:R:F127	R:R:I202	25.7951	3.77	Yes	Yes	4	8	5
51	R:R:A217	R:R:I202	16.7981	1.62	No	Yes	0	4	5
52	R:R:A217	R:R:Q204	15.6313	1.52	No	No	0	4	1
53	R:R:H206	R:R:Q204	14.4528	12.36	No	No	0	1	1
54	R:R:H206	R:R:P212	13.3267	6.1	No	No	0	1	3
55	R:R:P212	R:R:P214	10.9611	5.84	No	No	0	3	2
56	R:R:E142	R:R:L146	44.9268	5.3	Yes	No	0	5	6
57	R:R:L302	R:R:Y356	44.3361	12.89	No	Yes	0	8	9
58	R:R:L302	R:R:Y251	32.7902	4.69	No	Yes	0	8	9
59	R:R:S156	R:R:Y251	11.7817	10.17	No	Yes	8	9	9
60	R:R:L250	R:R:S156	10.5188	4.5	No	No	0	7	9
61	R:R:L299	R:R:Y251	15.64	15.24	No	Yes	0	8	9
62	R:R:L302	R:R:L355	11.8078	5.54	No	No	0	8	8
63	R:R:L355	R:R:V305	10.5188	4.47	No	No	0	8	7
64	R:R:E142	R:R:F313	42.2818	10.49	Yes	Yes	1	5	6
65	R:R:F239	R:R:L146	44.5427	13.4	Yes	No	0	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:F2	R:R:H331	3.39	5	No	No	0	4	0	1
L:L:F3	R:R:N124	6.04	0	No	No	0	4	0	1
L:L:L4	R:R:H331	10.29	5	No	No	0	4	0	1
L:L:F5	R:R:M121	7.46	0	Yes	No	0	5	0	1
L:L:F5	R:R:Q335	4.68	0	Yes	No	0	2	0	1
L:L:F5	R:R:H338	15.84	0	Yes	No	0	4	0	1
L:L:R6	R:R:E120	12.79	0	No	No	0	5	0	1
L:L:R6	R:R:N124	4.82	0	No	No	0	4	0	1
L:L:P7	R:R:Y228	4.17	0	No	Yes	0	4	0	1
L:L:P7	R:R:W320	25.67	0	No	Yes	0	4	0	1
L:L:R8	R:R:E117	16.28	1	Yes	No	0	6	0	1
L:L:R8	R:R:F313	5.34	1	Yes	Yes	0	6	0	1
L:L:R8	R:R:D316	4.76	1	Yes	No	0	5	0	1
L:L:R8	R:R:H338	23.7	1	Yes	No	0	4	0	1
L:L:R8	R:R:G342	6	1	Yes	No	0	6	0	1
L:L:R8	R:R:Y346	4.12	1	Yes	Yes	0	7	0	1
L:L:N9	R:R:T138	10.24	0	No	No	0	5	0	1
L:L:N9	R:R:N196	8.17	0	No	No	0	4	0	1
L:L:N9	R:R:H200	22.96	0	No	No	0	4	0	1
R:R:I63	R:R:Y67	3.63	0	No	Yes	5	7	2	2
R:R:I63	R:R:M121	5.83	0	No	No	5	5	2	1
R:R:L114	R:R:Y67	7.03	1	Yes	Yes	7	7	2	2
R:R:E117	R:R:Y67	7.86	1	No	Yes	6	7	1	2
R:R:Y346	R:R:Y67	6.95	1	Yes	Yes	7	7	1	2
R:R:L114	R:R:Y346	4.69	1	Yes	Yes	7	7	2	1
R:R:E120	R:R:L116	5.3	0	No	No	5	6	1	2
R:R:E117	R:R:Y346	11.22	1	No	Yes	6	7	1	1
R:R:T138	R:R:T197	9.42	0	No	No	5	6	1	2
R:R:E142	R:R:F313	10.49	1	Yes	Yes	5	6	2	1
R:R:E142	R:R:R317	15.12	1	Yes	Yes	5	6	2	2
R:R:N196	R:R:V231	4.43	0	No	No	4	6	1	2
R:R:N196	R:R:R317	3.62	0	No	Yes	4	6	1	2
R:R:H200	R:R:L221	6.43	2	No	No	4	5	1	2
R:R:H200	R:R:Y228	6.53	2	No	Yes	4	4	1	1
R:R:L221	R:R:Y228	19.93	2	No	Yes	5	4	2	1
R:R:L221	R:R:W320	7.97	2	No	Yes	5	4	2	1
R:R:R225	R:R:W320	16.99	0	No	Yes	4	4	2	1
R:R:V232	R:R:Y228	8.83	0	No	Yes	6	4	2	1
R:R:R317	R:R:V232	3.92	1	Yes	No	6	6	2	2
R:R:F313	R:R:W310	6.01	1	Yes	Yes	6	8	1	2
R:R:F345	R:R:W310	9.02	1	Yes	Yes	7	8	2	2
R:R:F313	R:R:H314	7.92	1	Yes	Yes	6	7	1	2
R:R:F313	R:R:R317	13.9	1	Yes	Yes	6	6	1	2
R:R:F313	R:R:F345	8.57	1	Yes	Yes	6	7	1	2
R:R:H314	R:R:R317	3.39	1	Yes	Yes	7	6	2	2
R:R:D316	R:R:V337	4.38	0	No	No	5	4	1	2
R:R:D316	R:R:S341	8.83	0	No	No	5	6	1	2
R:R:F334	R:R:W320	12.03	0	No	Yes	3	4	2	1
R:R:H331	R:R:V323	5.54	5	No	No	4	4	1	2
R:R:L332	R:R:Q335	3.99	0	No	No	1	2	2	1
R:R:F345	R:R:Y346	13.41	1	Yes	Yes	7	7	2	1
R:R:I70	R:R:Y346	2.42	0	No	Yes	8	7	2	1
R:R:L199	R:R:Y228	2.34	2	No	Yes	4	4	2	1
R:R:L59	R:R:Q335	1.33	0	No	No	3	2	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7W56_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.23
Number of Linked Nodes	257
Number of Links	289
Number of Hubs	32
Number of Links mediated by Hubs	128
Number of Communities	8
Number of Nodes involved in Communities	47
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	60364
Length Of Smallest Path	3
Average Path Length	17.9919
Length of Longest Path	42
Minimum Path Strength	1.32
Average Path Strength	6.83124
Maximum Path Strength	21.33
Minimum Path Correlation	0.7
Average Path Correlation	0.942963
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	52.3622
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.7943
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • neuropeptide signaling pathway • G-protein beta-subunit binding • fibroblast proliferation • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • neuropeptide receptor activity • neuromedin U receptor activity • neuromedin U binding • neuropeptide binding • peptide binding • electron transport chain • metabolic process • generation of precursor metabolites and energy • localization • transport • monoatomic anion transport • monoatomic ion transport • chloride transport • establishment of localization • inorganic anion transport • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • regulation of calcium-mediated signaling • positive regulation of calcium-mediated signaling • positive regulation of cellular process • regulation of signaling • positive regulation of intracellular signal transduction • regulation of response to stimulus • calcium-mediated signaling • regulation of cell communication • positive regulation of signaling • smooth muscle contraction • muscle contraction • muscle system process • periplasmic space
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9HB89
Sequence	>7W56_nogp_Chain_R L F M P I C A T Y L L I F V V G A V G N G L T C L V I L R H K A M R T P T N Y Y L F S L A V S D L L V L L V G L P L E L Y E M W H N Y P F L L G V G G C Y F R T L L F E M V C L A S V L N V T A L S V E R Y V A V V H P L Q A R S M V T R A H V R R V L G A V W G L A M L C S L P N T S L H G I R Q L H V P C R G P V P D S A V C M L V R P R A L Y N M V V Q T T A L L F F C L P M A I M S V L Y L L I G L R L R R E R R R Q V T K M L F V L V V V F G I C W A P F H A D R V M W S V V D G L H L A F Q H V H V I S G I F F Y L G S A A N P V L Y S L M S S R F R E T F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7W53	A	Peptide	Neuromedin U	NMUR1	Homo sapiens	Neuromedin-U-25	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2022-04-20	doi.org/10.1038/s41467-022-29683-w
	7W53 (No Gprot)	A	Peptide	Neuromedin U	NMUR1	Homo sapiens	Neuromedin-U-25	-		3.2	2022-04-20	doi.org/10.1038/s41467-022-29683-w
	7W56	A	Peptide	Neuromedin U	NMUR1	Homo sapiens	Neuromedin-S	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.9	2022-04-20	doi.org/10.1038/s41467-022-29683-w
	7W56 (No Gprot)	A	Peptide	Neuromedin U	NMUR1	Homo sapiens	Neuromedin-S	-		2.9	2022-04-20	doi.org/10.1038/s41467-022-29683-w

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