psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:K34	R:R:P31	5.02	No	No	0	5	4
2	L:L:E50	R:R:P31	11	No	No	0	0	4
3	R:R:C277	R:R:C32	7.28	No	No	0	6	9
4	L:L:Y13	R:R:C32	5.38	Yes	No	0	0	9
5	R:R:D284	R:R:H33	5.04	No	No	5	4	3
6	L:L:A7	R:R:H33	2.93	Yes	No	5	0	3
7	R:R:D36	R:R:K34	4.15	No	No	0	3	5
8	R:R:D36	R:R:V37	4.38	No	Yes	0	3	5
9	R:R:S281	R:R:V37	3.23	No	Yes	0	3	5
10	R:R:D284	R:R:V37	2.92	No	Yes	0	4	5
11	R:R:K38	R:R:N104	11.19	No	No	0	5	4
12	R:R:Q39	R:R:Q43	5.12	No	No	0	4	5
13	R:R:G41	R:R:Q288	4.93	No	No	0	3	4
14	R:R:L45	R:R:Y49	16.41	No	Yes	0	6	7
15	R:R:L45	R:R:Q288	7.99	No	No	0	6	4
16	R:R:P46	R:R:P47	5.84	No	No	0	5	5
17	R:R:A102	R:R:P46	3.74	No	No	0	5	5
18	R:R:L48	R:R:T292	10.32	No	No	0	5	5
19	R:R:A99	R:R:Y49	2.67	No	Yes	0	7	7
20	R:R:M295	R:R:Y49	8.38	Yes	Yes	0	7	7
21	L:L:P2	R:R:Y49	2.78	Yes	Yes	0	0	7
22	R:R:L95	R:R:V52	2.98	No	No	0	7	7
23	R:R:F53	R:R:F57	3.22	No	No	0	7	6
24	R:R:F53	R:R:L95	6.09	No	No	0	7	7
25	R:R:F53	R:R:P96	17.34	No	No	0	7	9
26	R:R:C299	R:R:G56	3.92	No	No	0	8	8
27	R:R:D88	R:R:N60	12.12	No	Yes	0	9	9
28	R:R:L89	R:R:N60	2.75	No	Yes	0	7	9
29	R:R:L92	R:R:N60	2.75	No	Yes	0	6	9
30	R:R:N60	R:R:P302	8.15	Yes	No	0	9	9
31	R:R:L65	R:R:M61	5.65	No	No	0	3	4
32	R:R:I66	R:R:L62	4.28	No	No	0	7	6
33	R:R:L67	R:R:V63	2.98	Yes	No	0	7	9
34	R:R:L82	R:R:V64	2.98	Yes	No	0	6	8
35	R:R:F312	R:R:I66	8.79	No	No	0	8	7
36	R:R:D78	R:R:L67	4.07	No	Yes	0	8	7
37	R:R:L67	R:R:L81	4.15	Yes	No	0	7	8
38	R:R:L67	R:R:L82	4.15	Yes	Yes	0	7	6
39	R:R:K72	R:R:L73	4.23	No	No	0	6	6
40	R:R:K72	R:R:L82	2.82	No	Yes	0	6	6
41	R:R:C75	R:R:D78	7.78	No	No	0	7	8
42	R:R:C75	R:R:K311	3.23	No	No	0	7	6
43	R:R:L76	R:R:Y80	8.21	Yes	Yes	3	6	7
44	R:R:D137	R:R:L76	9.5	No	Yes	3	8	6
45	R:R:L76	R:R:R152	13.36	Yes	Yes	3	6	7
46	R:R:D137	R:R:T77	2.89	No	No	0	8	7
47	R:R:F130	R:R:Y80	4.13	Yes	Yes	3	7	7
48	R:R:L133	R:R:Y80	9.38	Yes	Yes	3	6	7
49	R:R:T160	R:R:Y80	7.49	No	Yes	3	5	7
50	R:R:I86	R:R:L82	4.28	No	Yes	0	5	6
51	R:R:F130	R:R:N83	13.29	Yes	No	3	7	9
52	R:R:N83	R:R:S161	8.94	No	No	3	9	7
53	R:R:N83	R:R:W165	5.65	No	Yes	3	9	9
54	R:R:D88	R:R:L84	4.07	No	No	0	9	9
55	R:R:F130	R:R:L84	2.44	Yes	No	0	7	9
56	R:R:I131	R:R:L84	4.28	No	No	0	8	9
57	R:R:I86	R:R:W165	3.52	No	Yes	0	5	9
58	R:R:G126	R:R:S87	3.71	No	No	0	7	8
59	R:R:F130	R:R:S87	2.64	Yes	No	3	7	8
60	R:R:S87	R:R:W165	6.18	No	Yes	3	8	9
61	R:R:C298	R:R:D88	7.78	No	No	0	8	9
62	R:R:F91	R:R:Y120	12.38	Yes	No	0	6	6
63	R:R:F91	R:R:G123	3.01	Yes	No	0	6	8
64	R:R:F91	R:R:M295	3.73	Yes	Yes	0	6	7
65	R:R:C298	R:R:F91	4.19	No	Yes	0	8	6
66	R:R:L97	R:R:T94	2.95	No	Yes	2	6	7
67	R:R:T94	R:R:W98	7.28	Yes	Yes	2	7	6
68	R:R:F116	R:R:T94	3.89	Yes	Yes	2	6	7
69	R:R:L119	R:R:T94	2.95	No	Yes	0	4	7
70	R:R:L95	R:R:M295	2.83	No	Yes	0	7	7
71	R:R:F116	R:R:L97	10.96	Yes	No	2	6	6
72	R:R:S101	R:R:W98	2.47	No	Yes	0	4	6
73	L:L:Q1	R:R:W98	6.57	Yes	Yes	2	0	6
74	L:L:P2	R:R:W98	10.81	Yes	Yes	2	0	6
75	L:L:I5	R:R:W98	4.7	No	Yes	2	0	6
76	R:R:S101	R:R:W106	4.94	No	Yes	0	4	8
77	R:R:V107	R:R:W106	7.36	No	Yes	0	3	8
78	R:R:C113	R:R:W106	3.92	No	Yes	2	9	8
79	R:R:F116	R:R:W106	3.01	Yes	Yes	2	6	8
80	R:R:C181	R:R:W106	3.92	No	Yes	0	5	8
81	R:R:C190	R:R:W106	9.14	No	Yes	2	9	8
82	R:R:K114	R:R:N110	2.8	No	No	0	7	3
83	R:R:C181	R:R:N110	3.15	No	No	0	5	3
84	R:R:F116	R:R:M112	8.71	Yes	No	0	6	5
85	R:R:C113	R:R:C190	7.28	No	No	2	9	9
86	R:R:K114	R:R:T179	3	No	No	0	7	5
87	R:R:H121	R:R:T117	2.74	No	Yes	0	5	6
88	R:R:T117	R:R:T179	14.13	Yes	No	2	6	5
89	L:L:Q1	R:R:T117	12.76	Yes	Yes	2	0	6
90	R:R:G118	R:R:I176	3.53	No	No	0	6	5
91	R:R:E291	R:R:Y120	5.61	Yes	No	2	5	6
92	L:L:P2	R:R:Y120	9.74	Yes	No	2	0	6
93	R:R:H121	R:R:S172	2.79	No	No	0	5	7
94	R:R:H121	R:R:R206	4.51	No	Yes	0	5	5
95	R:R:I122	R:R:V169	3.07	No	No	0	6	4
96	R:R:I122	R:R:S172	4.64	No	No	0	6	7
97	R:R:F125	R:R:Y124	5.16	Yes	Yes	1	7	7
98	R:R:I128	R:R:Y124	6.04	No	Yes	0	8	7
99	R:R:R206	R:R:Y124	13.38	Yes	Yes	1	5	7
100	R:R:W256	R:R:Y124	7.72	Yes	Yes	1	9	7
101	R:R:F125	R:R:F129	3.22	Yes	No	0	7	5
102	R:R:A171	R:R:F125	4.16	No	Yes	0	5	7
103	R:R:F125	R:R:S172	2.64	Yes	No	0	7	7
104	R:R:F125	R:R:R206	3.21	Yes	Yes	1	7	5
105	R:R:F125	R:R:L209	4.87	Yes	No	0	7	4
106	R:R:G210	R:R:I128	3.53	No	No	0	6	8
107	R:R:F129	R:R:V167	3.93	No	No	0	5	4
108	R:R:F130	R:R:L133	3.65	Yes	Yes	3	7	6
109	R:R:F130	R:R:S161	3.96	Yes	No	3	7	7
110	R:R:F130	R:R:T164	11.67	Yes	No	3	7	7
111	R:R:F130	R:R:W165	10.02	Yes	Yes	3	7	9
112	R:R:I131	R:R:N301	4.25	No	No	1	8	9
113	R:R:I131	R:R:Y305	8.46	No	Yes	1	8	9
114	R:R:I132	R:R:I136	2.94	Yes	No	1	8	6
115	R:R:I132	R:R:L213	2.85	Yes	No	1	8	6
116	R:R:I132	R:R:P214	6.77	Yes	Yes	1	8	8
117	R:R:I132	R:R:I217	4.42	Yes	Yes	1	8	6
118	R:R:L133	R:R:T160	2.95	Yes	No	3	6	5
119	R:R:L133	R:R:T164	5.9	Yes	No	3	6	7
120	R:R:L134	R:R:Y305	3.52	No	Yes	0	9	9
121	R:R:I217	R:R:T135	3.04	Yes	Yes	1	6	9
122	R:R:M218	R:R:T135	4.52	No	Yes	1	8	9
123	R:R:C221	R:R:T135	3.38	No	Yes	0	7	9
124	R:R:T135	R:R:Y222	3.75	Yes	Yes	1	9	8
125	R:R:I136	R:R:I217	2.94	No	Yes	1	6	6
126	R:R:D137	R:R:R152	11.91	No	Yes	3	8	7
127	R:R:R138	R:R:Y305	7.2	No	Yes	0	9	9
128	R:R:V143	R:R:Y139	12.62	No	No	0	7	8
129	R:R:C221	R:R:Y139	9.41	No	No	0	7	8
130	R:R:F147	R:R:L140	2.44	No	No	0	4	5
131	R:R:A141	R:R:R152	2.77	No	Yes	0	8	7
132	R:R:I142	R:R:I225	7.36	No	No	0	8	8
133	R:R:I142	R:R:T228	3.04	No	No	0	8	5
134	R:R:H144	R:R:V143	9.69	No	No	0	6	7
135	R:R:A151	R:R:F147	4.16	No	No	0	3	4
136	R:R:A148	R:R:R152	2.77	No	Yes	0	5	7
137	R:R:T153	R:R:T155	3.14	No	No	0	7	4
138	R:R:F156	R:R:T160	7.78	No	No	0	4	5
139	R:R:S161	R:R:W165	2.47	No	Yes	3	7	9
140	R:R:P174	R:R:V173	3.53	No	No	0	7	5
141	R:R:I177	R:R:V173	3.07	No	No	0	5	5
142	R:R:F194	R:R:G175	3.01	Yes	No	0	4	4
143	R:R:F178	R:R:F194	7.5	No	Yes	0	4	4
144	R:R:F178	R:R:P195	10.11	No	No	0	4	4
145	L:L:Q1	R:R:T179	2.83	Yes	No	2	0	5
146	R:R:K180	R:R:Y193	5.97	No	Yes	0	4	4
147	R:R:E184	R:R:Q182	2.55	No	No	7	2	2
148	R:R:Q182	R:R:Y193	13.53	No	Yes	7	2	4
149	R:R:K183	R:R:Y188	20.3	No	No	0	1	5
150	R:R:E184	R:R:Y193	3.37	No	Yes	7	2	4
151	L:L:R29	R:R:D185	7.15	No	No	0	0	3
152	L:L:Q1	R:R:C190	6.1	Yes	No	2	0	9
153	R:R:G191	R:R:P192	4.06	No	Yes	2	4	4
154	L:L:Q1	R:R:G191	4.93	Yes	No	2	0	4
155	L:L:Q1	R:R:P192	4.74	Yes	Yes	2	0	4
156	L:L:N6	R:R:P192	8.15	No	Yes	2	0	4
157	R:R:F194	R:R:N199	6.04	Yes	No	6	4	3
158	R:R:F194	R:R:H202	12.44	Yes	No	0	4	5
159	L:L:S34	R:R:F194	3.96	No	Yes	6	0	4
160	R:R:P195	R:R:W198	12.16	No	No	0	4	3
161	L:L:S34	R:R:N199	7.45	No	No	6	0	3
162	R:R:F201	R:R:M205	3.73	No	No	0	4	4
163	R:R:H202	R:R:R206	5.64	No	Yes	0	5	5
164	R:R:I263	R:R:T203	4.56	No	No	0	6	5
165	R:R:T203	R:R:T267	14.13	No	No	0	5	5
166	R:R:I204	R:R:I208	2.94	No	No	0	4	4
167	R:R:L209	R:R:M205	2.83	No	No	0	4	4
168	R:R:N207	R:R:N260	5.45	No	No	0	5	8
169	R:R:L264	R:R:N207	5.49	No	No	0	6	5
170	R:R:G210	R:R:P214	4.06	No	Yes	0	6	8
171	R:R:L211	R:R:L215	2.77	No	No	0	8	6
172	R:R:L211	R:R:T257	5.9	No	Yes	0	8	5
173	R:R:L211	R:R:N260	9.61	No	No	0	8	8
174	R:R:L213	R:R:P214	3.28	No	Yes	1	6	8
175	R:R:I217	R:R:L213	2.85	Yes	No	1	6	6
176	R:R:P214	R:R:Y252	8.34	Yes	Yes	1	8	9
177	R:R:L215	R:R:Y252	4.69	No	Yes	0	6	9
178	R:R:I220	R:R:L216	5.71	No	No	0	4	4
179	R:R:M218	R:R:Y222	3.59	No	Yes	1	8	8
180	R:R:M218	R:R:Y252	5.99	No	Yes	1	8	9
181	R:R:I225	R:R:Y222	3.63	No	Yes	0	8	8
182	R:R:I245	R:R:Y222	7.25	No	Yes	0	7	8
183	R:R:I248	R:R:Y222	3.63	No	Yes	0	8	8
184	R:R:M249	R:R:Y222	7.18	No	Yes	0	8	8
185	R:R:I225	R:R:L229	2.85	No	No	0	8	8
186	R:R:L226	R:R:V242	4.47	No	No	10	4	6
187	R:R:I245	R:R:L226	5.71	No	No	0	7	4
188	R:R:F246	R:R:L226	2.44	No	No	10	4	4
189	R:R:K237	R:R:N234	8.39	No	No	0	4	2
190	R:R:E235	R:R:H239	9.85	No	No	0	1	4
191	R:R:H239	R:R:R243	3.39	No	No	0	4	5
192	R:R:R240	R:R:V308	3.92	No	No	0	6	6
193	R:R:R240	R:R:R313	3.2	No	No	0	6	8
194	R:R:F246	R:R:V242	2.62	No	No	10	4	6
195	R:R:I248	R:R:V244	3.07	No	No	0	8	8
196	R:R:V244	R:R:V308	3.21	No	No	0	8	6
197	R:R:F246	R:R:M249	3.73	No	No	0	4	8
198	R:R:I248	R:R:I304	2.94	No	No	0	8	8
199	R:R:I250	R:R:L254	2.85	No	No	0	5	6
200	R:R:F255	R:R:V251	3.93	Yes	No	1	8	6
201	R:R:H297	R:R:V251	2.77	Yes	No	1	9	6
202	R:R:W256	R:R:Y252	12.54	Yes	Yes	1	9	9
203	R:R:H297	R:R:Y252	5.44	Yes	Yes	1	9	9
204	R:R:F253	R:R:T257	16.86	No	Yes	0	5	5
205	R:R:F255	R:R:L293	7.31	Yes	No	0	8	7
206	R:R:F255	R:R:T296	2.59	Yes	No	0	8	5
207	R:R:F255	R:R:H297	9.05	Yes	Yes	1	8	9
208	R:R:G294	R:R:W256	5.63	No	Yes	0	8	9
209	R:R:H297	R:R:W256	17.98	Yes	Yes	1	9	9
210	R:R:P258	R:R:T257	3.5	No	Yes	0	9	5
211	R:R:I261	R:R:T257	3.04	No	Yes	0	6	5
212	R:R:I263	R:R:Y259	10.88	No	No	0	6	6
213	R:R:T290	R:R:Y259	8.74	No	No	0	7	6
214	R:R:E291	R:R:Y259	11.22	Yes	No	0	5	6
215	R:R:A286	R:R:V262	3.39	No	No	0	5	5
216	R:R:T287	R:R:V262	3.17	No	No	0	4	5
217	R:R:F268	R:R:L264	7.31	No	No	9	4	6
218	R:R:F272	R:R:L264	2.44	Yes	No	9	1	6
219	R:R:F272	R:R:L265	2.44	Yes	No	0	1	4
220	R:R:L265	R:R:L283	5.54	No	No	0	4	4
221	R:R:N266	R:R:Q269	3.96	No	Yes	0	4	4
222	R:R:F268	R:R:F272	5.36	No	Yes	9	4	1
223	R:R:Q269	R:R:S275	2.89	Yes	No	0	4	3
224	R:R:Q269	R:R:T280	2.83	Yes	No	0	4	2
225	L:L:P37	R:R:Q269	6.32	No	Yes	0	0	4
226	R:R:F271	R:R:F272	5.36	No	Yes	0	1	1
227	L:L:Y13	R:R:S275	8.9	Yes	No	0	0	3
228	R:R:N276	R:R:S279	5.96	No	No	0	4	1
229	R:R:E278	R:R:Q282	2.55	No	No	0	2	3
230	L:L:Y13	R:R:T280	12.48	Yes	No	0	0	2
231	L:L:A7	R:R:D284	4.63	Yes	No	5	0	4
232	L:L:D3	R:R:T287	4.34	No	No	0	0	4
233	L:L:A4	R:R:Q288	3.03	No	No	0	0	4
234	R:R:E291	R:R:M295	6.77	Yes	Yes	0	5	7
235	L:L:P2	R:R:E291	6.29	Yes	Yes	2	0	5
236	R:R:H297	R:R:N301	10.2	Yes	No	1	9	9
237	R:R:I300	R:R:I304	2.94	No	No	0	6	8
238	R:R:N301	R:R:Y305	4.65	No	Yes	1	9	9
239	R:R:F307	R:R:I303	3.77	No	No	0	7	7
240	R:R:A306	R:R:F312	8.32	No	No	0	7	8
241	R:R:F307	R:R:F312	8.57	No	No	0	7	8
242	L:L:N6	L:L:Q1	9.24	No	Yes	2	0	0
243	L:L:I5	L:L:P2	6.77	No	Yes	2	0	0
244	L:L:D3	L:L:K35	5.53	No	No	0	0	0
245	L:L:K35	L:L:P8	3.35	No	Yes	0	0	0
246	L:L:C36	L:L:P8	3.77	No	Yes	0	0	0
247	L:L:T10	L:L:V9	3.17	No	No	0	0	0
248	L:L:I31	L:L:T10	3.04	No	No	0	0	0
249	L:L:E50	L:L:T10	2.82	No	No	0	0	0
250	L:L:C11	L:L:C36	7.28	No	No	11	0	0
251	L:L:A40	L:L:C12	3.61	No	No	0	0	0
252	L:L:C12	L:L:C52	7.28	No	No	0	0	0
253	L:L:I51	L:L:N17	7.08	No	No	0	0	0
254	L:L:K19	L:L:W59	19.73	No	Yes	0	0	0
255	L:L:I20	L:L:L25	5.71	Yes	Yes	4	0	0
256	L:L:F43	L:L:I20	3.77	Yes	Yes	4	0	0
257	L:L:I20	L:L:I51	7.36	Yes	No	0	0	0
258	L:L:Q23	L:L:S21	7.22	No	No	0	0	0
259	L:L:R24	L:L:S21	2.64	No	No	0	0	0
260	L:L:H66	L:L:V22	5.54	No	No	0	0	0
261	L:L:F43	L:L:L25	10.96	Yes	Yes	4	0	0
262	L:L:L25	L:L:S63	3	Yes	No	4	0	0
263	L:L:L25	L:L:L67	2.77	Yes	No	0	0	0
264	L:L:A26	L:L:I46	3.25	No	No	0	0	0
265	L:L:R29	L:L:S27	2.64	No	No	8	0	0
266	L:L:K44	L:L:S27	6.12	No	No	8	0	0
267	L:L:R30	L:L:Y28	7.2	No	No	0	0	0
268	L:L:V41	L:L:Y28	6.31	Yes	No	0	0	0
269	L:L:M64	L:L:Y28	8.38	No	No	0	0	0
270	L:L:K44	L:L:R29	7.43	No	No	8	0	0
271	L:L:R30	L:L:T32	6.47	No	No	0	0	0
272	L:L:I31	L:L:I42	4.42	No	No	0	0	0
273	L:L:E39	L:L:T32	11.29	No	No	0	0	0
274	L:L:F43	L:L:V41	7.87	Yes	Yes	4	0	0
275	L:L:A53	L:L:V41	3.39	No	Yes	4	0	0
276	L:L:V41	L:L:V60	3.21	Yes	Yes	4	0	0
277	L:L:E50	L:L:I42	6.83	No	No	0	0	0
278	L:L:A53	L:L:F43	2.77	No	Yes	4	0	0
279	L:L:F43	L:L:W59	3.01	Yes	Yes	4	0	0
280	L:L:F43	L:L:S63	5.28	Yes	No	4	0	0
281	L:L:T45	L:L:V47	4.76	No	No	0	0	0
282	L:L:I51	L:L:T45	3.04	No	No	0	0	0
283	L:L:K49	L:L:V47	4.55	No	No	0	0	0
284	L:L:A53	L:L:V60	3.39	No	Yes	4	0	0
285	L:L:D54	L:L:P55	6.44	Yes	No	0	0	0
286	L:L:D54	L:L:K56	2.77	Yes	No	0	0	0
287	L:L:D54	L:L:Q57	5.22	Yes	No	0	0	0
288	L:L:Q57	L:L:W59	3.29	No	Yes	4	0	0
289	L:L:Q57	L:L:V60	2.87	No	Yes	4	0	0
290	L:L:D62	L:L:K58	6.91	No	No	0	0	0
291	L:L:V60	L:L:W59	9.81	Yes	Yes	4	0	0
292	L:L:M64	L:L:Q61	4.08	No	No	0	0	0
293	L:L:D65	L:L:Q61	6.53	No	No	0	0	0
294	R:R:L230	R:R:R238	2.43	No	No	0	4	5
295	R:R:N200	R:R:R196	2.41	No	No	0	3	3
296	L:L:D54	L:L:F15	2.39	Yes	No	0	0	0
297	R:R:L90	R:R:W165	2.28	No	Yes	0	7	9
298	R:R:G126	R:R:G127	2.11	No	No	0	7	9
299	R:R:A168	R:R:G126	1.95	No	No	0	8	7
300	R:R:W106	R:R:Y188	1.93	Yes	No	0	8	5
301	L:L:C11	L:L:P37	1.88	No	No	11	0	0
302	L:L:C36	L:L:P37	1.88	No	No	11	0	0
303	R:R:A30	R:R:P31	1.87	No	No	0	4	4
304	R:R:A99	R:R:P46	1.87	No	No	0	7	5
305	L:L:A7	L:L:P8	1.87	Yes	Yes	0	0	0
306	R:R:G224	R:R:S223	1.86	No	No	0	4	4
307	R:R:G59	R:R:V58	1.84	No	No	0	7	4
308	R:R:G224	R:R:V143	1.84	No	No	0	4	7
309	R:R:G118	R:R:T117	1.82	No	Yes	0	6	6
310	L:L:C52	R:R:A30	1.81	No	No	0	0	4
311	L:L:P8	L:L:S33	1.78	Yes	No	0	0	0
312	R:R:G109	R:R:M112	1.75	No	No	0	7	5
313	L:L:K49	R:R:G29	1.74	No	No	0	0	1
314	R:R:G224	R:R:K227	1.74	No	No	0	4	4
315	R:R:G56	R:R:L92	1.71	No	No	0	8	6
316	R:R:G157	R:R:L76	1.71	No	Yes	0	7	6
317	R:R:A85	R:R:V63	1.7	No	No	0	9	9
318	R:R:A306	R:R:V63	1.7	No	No	0	7	9
319	R:R:A85	R:R:V64	1.7	No	No	0	9	8
320	L:L:K35	R:R:P192	1.67	No	Yes	0	0	4
321	R:R:C70	R:R:K71	1.62	No	No	0	5	6
322	R:R:C75	R:R:K74	1.62	No	No	0	7	6
323	R:R:S223	R:R:V219	1.62	No	No	0	4	4
324	L:L:S21	L:L:V22	1.62	No	No	0	0	0
325	L:L:A7	R:R:K38	1.61	Yes	No	0	0	5
326	R:R:V154	R:R:V158	1.6	No	No	0	3	4
327	R:R:V187	R:R:V189	1.6	No	No	0	4	3
328	R:R:T155	R:R:V159	1.59	No	No	0	4	3
329	R:R:T247	R:R:V251	1.59	No	No	0	5	6
330	R:R:A241	R:R:L229	1.58	No	No	0	7	8
331	R:R:C232	R:R:N234	1.57	No	No	0	5	2
332	R:R:C277	R:R:N276	1.57	No	No	0	6	4
333	R:R:T292	R:R:T296	1.57	No	No	0	5	5
334	L:L:C52	L:L:N17	1.57	No	No	0	0	0
335	R:R:C70	R:R:D78	1.56	No	No	0	5	8
336	R:R:I68	R:R:V64	1.54	No	No	0	3	8
337	R:R:I79	R:R:V154	1.54	No	No	0	7	3
338	R:R:I163	R:R:V159	1.54	No	No	0	4	3
339	R:R:I163	R:R:V167	1.54	No	No	0	4	4
340	R:R:I93	R:R:T94	1.52	No	Yes	0	4	7
341	R:R:F55	R:R:G56	1.51	No	No	0	6	8
342	R:R:F272	R:R:G273	1.51	Yes	No	0	1	3
343	R:R:G197	R:R:R196	1.5	No	No	0	2	3
344	R:R:L73	R:R:V154	1.49	No	No	0	6	3
345	R:R:L166	R:R:V162	1.49	No	No	0	4	4
346	R:R:N104	R:R:V187	1.48	No	No	0	4	4
347	L:L:V9	R:R:D185	1.46	No	No	0	0	3
348	R:R:N200	R:R:T267	1.46	No	No	0	3	5
349	L:L:N17	L:L:T16	1.46	No	No	0	0	0
350	R:R:Q285	R:R:V37	1.43	No	Yes	0	1	5
351	R:R:I163	R:R:L166	1.43	No	No	0	4	4
352	R:R:L115	R:R:L119	1.38	No	No	0	4	4
353	R:R:I40	R:R:Q39	1.37	No	No	0	4	4
354	R:R:I40	R:R:Q285	1.37	No	No	0	4	1
355	L:L:D62	L:L:D65	1.33	No	No	0	0	0
356	L:L:H66	L:L:K69	1.31	No	No	0	0	0
357	R:R:F178	R:R:I177	1.26	No	No	0	4	5
358	R:R:V189	R:R:Y193	1.26	No	Yes	0	3	4
359	L:L:I20	L:L:R24	1.25	Yes	No	0	0	0
360	L:L:I46	L:L:R24	1.25	No	No	0	0	0
361	R:R:F35	R:R:K34	1.24	No	No	0	1	5
362	R:R:L140	R:R:R152	1.21	No	Yes	0	5	7
363	R:R:E235	R:R:R238	1.16	No	No	0	1	5
364	L:L:N14	L:L:Y13	1.16	No	Yes	0	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V37	2.99	4	0	5
2	R:R:Y49	7.56	4	0	7
3	R:R:N60	6.4425	4	0	9
4	R:R:L67	3.8375	4	0	7
5	R:R:L76	8.195	4	3	6
6	R:R:Y80	7.3025	4	3	7
7	R:R:L82	3.5575	4	0	6
8	R:R:F91	5.8275	4	0	6
9	R:R:T94	3.718	5	2	7
10	R:R:W98	6.366	5	2	6
11	R:R:W106	4.88857	7	2	8
12	R:R:F116	6.6425	4	2	6
13	R:R:T117	7.8625	4	2	6
14	R:R:Y124	8.075	4	1	7
15	R:R:F125	3.87667	6	1	7
16	R:R:F130	6.475	8	3	7
17	R:R:I132	4.245	4	1	8
18	R:R:L133	5.47	4	3	6
19	R:R:T135	3.6725	4	1	9
20	R:R:R152	6.404	5	3	7
21	R:R:W165	5.02	6	3	9
22	R:R:P192	4.655	4	2	4
23	R:R:Y193	6.0325	4	7	4
24	R:R:F194	6.59	5	6	4
25	R:R:R206	6.685	4	1	5
26	R:R:P214	5.6125	4	1	8
27	R:R:I217	3.3125	4	1	6
28	R:R:Y222	4.83833	6	1	8
29	R:R:Y252	7.4	5	1	9
30	R:R:F255	5.72	4	1	8
31	R:R:W256	10.9675	4	1	9
32	R:R:T257	7.325	4	0	5
33	R:R:Q269	4	4	0	4
34	R:R:F272	3.422	5	9	1
35	R:R:E291	7.4725	4	2	5
36	R:R:M295	5.4275	4	0	7
37	R:R:H297	9.088	5	1	9
38	R:R:Y305	5.9575	4	1	9
39	L:L:Q1	6.73857	7	2	0
40	L:L:P2	7.278	5	2	0
41	L:L:A7	2.76	4	5	0
42	L:L:P8	2.6925	4	0	0
43	L:L:Y13	6.98	4	0	0
44	L:L:I20	4.5225	4	4	0
45	L:L:L25	5.61	4	4	0
46	L:L:V41	5.195	4	4	0
47	L:L:F43	5.61	6	4	0
48	L:L:D54	4.205	4	0	0
49	L:L:W59	8.96	4	4	0
50	L:L:V60	4.82	4	4	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E50	R:R:P31	13.3212	11	No	No	0	0	4
2	R:R:K34	R:R:P31	65.6934	5.02	No	No	0	5	4
3	L:L:Y13	R:R:C32	10.6593	5.38	Yes	No	0	0	9
4	L:L:P37	R:R:Q269	21.0687	6.32	No	Yes	0	0	4
5	L:L:C36	L:L:P37	22.2509	1.88	No	No	11	0	0
6	L:L:C36	L:L:P8	24.7937	3.77	No	Yes	0	0	0
7	L:L:A7	L:L:P8	82.6722	1.87	Yes	Yes	0	0	0
8	L:L:A7	R:R:D284	74.3137	4.63	Yes	No	5	0	4
9	R:R:D284	R:R:V37	73.7266	2.92	No	Yes	0	4	5
10	R:R:D36	R:R:V37	68.4426	4.38	No	Yes	0	3	5
11	R:R:D36	R:R:K34	67.5341	4.15	No	No	0	3	5
12	L:L:A7	R:R:K38	10.7863	1.61	Yes	No	0	0	5
13	L:L:P2	R:R:Y49	13.1466	2.78	Yes	Yes	0	0	7
14	L:L:P2	R:R:W98	61.1512	10.81	Yes	Yes	2	0	6
15	L:L:Q1	R:R:W98	64.3486	6.57	Yes	Yes	2	0	6
16	L:L:Q1	R:R:P192	99.7342	4.74	Yes	Yes	2	0	4
17	L:L:K35	R:R:P192	100	1.67	No	Yes	0	0	4
18	L:L:K35	L:L:P8	97.0843	3.35	No	Yes	0	0	0
19	L:L:Q1	R:R:T117	72.961	12.76	Yes	Yes	2	0	6
20	R:R:H121	R:R:T117	74.1987	2.74	No	Yes	0	5	6
21	R:R:H121	R:R:R206	63.5354	4.51	No	Yes	0	5	5
22	R:R:R206	R:R:Y124	53.007	13.38	Yes	Yes	1	5	7
23	R:R:W256	R:R:Y124	55.9981	7.72	Yes	Yes	1	9	7
24	R:R:H297	R:R:W256	17.0858	17.98	Yes	Yes	1	9	9
25	L:L:P2	R:R:E291	13.1109	6.29	Yes	Yes	2	0	5
26	R:R:L95	R:R:M295	10.1119	2.83	No	Yes	0	7	7
27	R:R:C298	R:R:D88	51.2694	7.78	No	No	0	8	9
28	R:R:C298	R:R:F91	51.3924	4.19	No	Yes	0	8	6
29	R:R:F91	R:R:Y120	39.8009	12.38	Yes	No	0	6	6
30	L:L:P2	R:R:Y120	35.4451	9.74	Yes	No	2	0	6
31	R:R:L67	R:R:L82	18.7758	4.15	Yes	Yes	0	7	6
32	R:R:I86	R:R:L82	29.3875	4.28	No	Yes	0	5	6
33	R:R:I86	R:R:W165	30.5141	3.52	No	Yes	0	5	9
34	R:R:F130	R:R:W165	32.1009	10.02	Yes	Yes	3	7	9
35	R:R:F130	R:R:L84	56.9978	2.44	Yes	No	0	7	9
36	R:R:D88	R:R:L84	50.603	4.07	No	No	0	9	9
37	R:R:F130	R:R:Y80	16.3043	4.13	Yes	Yes	3	7	7
38	R:R:L76	R:R:Y80	12.738	8.21	Yes	Yes	3	6	7
39	R:R:I131	R:R:L84	34.7152	4.28	No	No	0	8	9
40	R:R:I131	R:R:N301	33.3148	4.25	No	No	1	8	9
41	R:R:H297	R:R:N301	36.302	10.2	Yes	No	1	9	9
42	R:R:T94	R:R:W98	10.4292	7.28	Yes	Yes	2	7	6
43	R:R:H121	R:R:S172	10.941	2.79	No	No	0	5	7
44	R:R:F125	R:R:S172	10.6791	2.64	Yes	No	0	7	7
45	R:R:F125	R:R:F129	15.7688	3.22	Yes	No	0	7	5
46	R:R:F129	R:R:V167	13.825	3.93	No	No	0	5	4
47	R:R:W256	R:R:Y252	38.5037	12.54	Yes	Yes	1	9	9
48	R:R:M218	R:R:T135	12.5674	4.52	No	Yes	1	8	9
49	R:R:M218	R:R:Y252	37.5198	5.99	No	Yes	1	8	9
50	R:R:C221	R:R:T135	11.0084	3.38	No	Yes	0	7	9
51	R:R:M218	R:R:Y222	23.8456	3.59	No	Yes	1	8	8
52	R:R:I163	R:R:V167	11.8732	1.54	No	No	0	4	4
53	R:R:H202	R:R:R206	14.3089	5.64	No	Yes	0	5	5
54	R:R:F194	R:R:H202	13.0474	12.44	Yes	No	0	4	5
55	R:R:I263	R:R:Y259	12.4445	10.88	No	No	0	6	6
56	R:R:E291	R:R:Y259	16.5305	11.22	Yes	No	0	5	6
57	R:R:I263	R:R:T203	10.3896	4.56	No	No	0	6	5
58	R:R:L215	R:R:Y252	19.9897	4.69	No	Yes	0	6	9
59	R:R:L211	R:R:L215	18.7123	2.77	No	No	0	8	6
60	R:R:L211	R:R:N260	12.2064	9.61	No	No	0	8	8
61	R:R:N207	R:R:N260	10.8815	5.45	No	No	0	5	8
62	L:L:C52	R:R:A30	54.0503	1.81	No	No	0	0	4
63	R:R:A30	R:R:P31	55.0698	1.87	No	No	0	4	4
64	L:L:I51	L:L:N17	48.8218	7.08	No	No	0	0	0
65	L:L:C52	L:L:N17	50.9322	1.57	No	No	0	0	0
66	L:L:F43	L:L:W59	10.4094	3.01	Yes	Yes	4	0	0
67	L:L:F43	L:L:I20	29.3042	3.77	Yes	Yes	4	0	0
68	L:L:I20	L:L:I51	43.4029	7.36	Yes	No	0	0	0
69	L:L:I20	L:L:R24	10.7863	1.25	Yes	No	0	0	0
70	L:L:V41	L:L:Y28	12.0398	6.31	Yes	No	0	0	0
71	L:L:F43	L:L:V41	14.2455	7.87	Yes	Yes	4	0	0
72	R:R:F91	R:R:M295	12.2778	3.73	Yes	Yes	0	6	7
73	R:R:H297	R:R:Y252	22.9887	5.44	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K34	R:R:P31	5.02	0	No	No	5	4	2	1
L:L:E50	R:R:P31	11	0	No	No	0	4	0	1
R:R:C277	R:R:C32	7.28	0	No	No	6	9	2	1
L:L:Y13	R:R:C32	5.38	0	Yes	No	0	9	0	1
R:R:D284	R:R:H33	5.04	5	No	No	4	3	1	1
L:L:A7	R:R:H33	2.93	5	Yes	No	0	3	0	1
R:R:D284	R:R:V37	2.92	5	No	Yes	4	5	1	2
R:R:K38	R:R:N104	11.19	0	No	No	5	4	1	2
R:R:G41	R:R:Q288	4.93	0	No	No	3	4	2	1
R:R:L45	R:R:Y49	16.41	0	No	Yes	6	7	2	1
R:R:L45	R:R:Q288	7.99	0	No	No	6	4	2	1
R:R:A99	R:R:Y49	2.67	0	No	Yes	7	7	2	1
R:R:M295	R:R:Y49	8.38	0	Yes	Yes	7	7	2	1
L:L:P2	R:R:Y49	2.78	2	Yes	Yes	0	7	0	1
R:R:F91	R:R:Y120	12.38	0	Yes	No	6	6	2	1
R:R:F91	R:R:M295	3.73	0	Yes	Yes	6	7	2	2
R:R:T94	R:R:W98	7.28	2	Yes	Yes	7	6	2	1
R:R:S101	R:R:W98	2.47	0	No	Yes	4	6	2	1
L:L:Q1	R:R:W98	6.57	2	Yes	Yes	0	6	0	1
L:L:P2	R:R:W98	10.81	2	Yes	Yes	0	6	0	1
L:L:I5	R:R:W98	4.7	2	No	Yes	0	6	0	1
R:R:S101	R:R:W106	4.94	0	No	Yes	4	8	2	2
R:R:C113	R:R:W106	3.92	2	No	Yes	9	8	2	2
R:R:C190	R:R:W106	9.14	2	No	Yes	9	8	1	2
R:R:C113	R:R:C190	7.28	2	No	No	9	9	2	1
R:R:K114	R:R:T179	3	0	No	No	7	5	2	1
R:R:H121	R:R:T117	2.74	0	No	Yes	5	6	2	1
R:R:T117	R:R:T179	14.13	2	Yes	No	6	5	1	1
L:L:Q1	R:R:T117	12.76	2	Yes	Yes	0	6	0	1
R:R:E291	R:R:Y120	5.61	2	Yes	No	5	6	1	1
L:L:P2	R:R:Y120	9.74	2	Yes	No	0	6	0	1
R:R:F194	R:R:G175	3.01	6	Yes	No	4	4	1	2
R:R:F178	R:R:F194	7.5	0	No	Yes	4	4	2	1
L:L:Q1	R:R:T179	2.83	2	Yes	No	0	5	0	1
L:L:R29	R:R:D185	7.15	8	No	No	0	3	0	1
L:L:Q1	R:R:C190	6.1	2	Yes	No	0	9	0	1
R:R:G191	R:R:P192	4.06	2	No	Yes	4	4	1	1
L:L:Q1	R:R:G191	4.93	2	Yes	No	0	4	0	1
L:L:Q1	R:R:P192	4.74	2	Yes	Yes	0	4	0	1
L:L:N6	R:R:P192	8.15	2	No	Yes	0	4	0	1
R:R:F194	R:R:N199	6.04	6	Yes	No	4	3	1	1
R:R:F194	R:R:H202	12.44	6	Yes	No	4	5	1	2
L:L:S34	R:R:F194	3.96	6	No	Yes	0	4	0	1
L:L:S34	R:R:N199	7.45	6	No	No	0	3	0	1
R:R:E291	R:R:Y259	11.22	2	Yes	No	5	6	1	2
R:R:T287	R:R:V262	3.17	0	No	No	4	5	1	2
R:R:N266	R:R:Q269	3.96	0	No	Yes	4	4	2	1
R:R:Q269	R:R:S275	2.89	0	Yes	No	4	3	1	1
R:R:Q269	R:R:T280	2.83	0	Yes	No	4	2	1	1
L:L:P37	R:R:Q269	6.32	11	No	Yes	0	4	0	1
L:L:Y13	R:R:S275	8.9	0	Yes	No	0	3	0	1
L:L:Y13	R:R:T280	12.48	0	Yes	No	0	2	0	1
L:L:A7	R:R:D284	4.63	5	Yes	No	0	4	0	1
L:L:D3	R:R:T287	4.34	0	No	No	0	4	0	1
L:L:A4	R:R:Q288	3.03	0	No	No	0	4	0	1
R:R:E291	R:R:M295	6.77	2	Yes	Yes	5	7	1	2
L:L:P2	R:R:E291	6.29	2	Yes	Yes	0	5	0	1
R:R:A30	R:R:P31	1.87	0	No	No	4	4	1	1
R:R:G118	R:R:T117	1.82	0	No	Yes	6	6	2	1
L:L:C52	R:R:A30	1.81	0	No	No	0	4	0	1
L:L:K49	R:R:G29	1.74	0	No	No	0	1	0	1
L:L:K35	R:R:P192	1.67	0	No	Yes	0	4	0	1
L:L:A7	R:R:K38	1.61	5	Yes	No	0	5	0	1
L:L:V9	R:R:D185	1.46	0	No	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XA3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	324
Number of Links	364
Number of Hubs	50
Number of Links mediated by Hubs	186
Number of Communities	11
Number of Nodes involved in Communities	78
Number of Links involved in Communities	105

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	57975
Length Of Smallest Path	3
Average Path Length	15.7527
Length of Longest Path	40
Minimum Path Strength	1.25
Average Path Strength	5.4958
Maximum Path Strength	14.77
Minimum Path Correlation	0.7
Average Path Correlation	0.941804
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	56.8043
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.0371
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • Interleukin 8-like chemokines • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • Interleukin 8-like chemokines • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41597
Sequence	>7XA3_nogp_Chain_R G A P C H K F D V K Q I G A Q L L P P L Y S L V F I F G F V G N M L V V L I L I N C K K L K C L T D I Y L L N L A I S D L L F L I T L P L W A H S A A N E W V F G N A M C K L F T G L Y H I G Y F G G I F F I I L L T I D R Y L A I V H A V F A L K A R T V T F G V V T S V I T W L V A V F A S V P G I I F T K C Q K E D S V Y V C G P Y F P R G W N N F H T I M R N I L G L V L P L L I M V I C Y S G I L K T L L R C R N E K K R H R A V R V I F T I M I V Y F L F W T P Y N I V I L L N T F Q E F F G L S N C E S T S Q L D Q A T Q V T E T L G M T H C C I N P I I Y A F V G E K F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5T1A	A	Protein	Chemokine	CCR2	Homo sapiens	BMS-681	PubChem 12093170	-	2.81	2016-12-14	doi.org/10.1038/nature20605
	6GPS	A	Protein	Chemokine	CCR2	Homo sapiens	MK0812	-	-	3.3	2019-01-02	doi.org/10.1016/j.str.2018.10.027
	6GPX	A	Protein	Chemokine	CCR2	Homo sapiens	MK0812	-	-	2.7	2019-01-02	doi.org/10.1016/j.str.2018.10.027
	7XA3	A	Protein	Chemokine	CCR2	Homo sapiens	CCL2	-	Gi1/β1/γ2	2.9	2022-08-24	doi.org/10.1038/s41421-022-00403-4
	7XA3 (No Gprot)	A	Protein	Chemokine	CCR2	Homo sapiens	CCL2	-		2.9	2022-08-24	doi.org/10.1038/s41421-022-00403-4

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