psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L33	R:R:M28	7.07	No	Yes	0	1	4
2	R:R:M28	R:R:Q286	6.8	Yes	No	0	4	4
3	R:R:M28	R:R:Q287	2.72	Yes	No	0	4	1
4	R:R:L35	R:R:Q32	2.66	No	No	0	4	1
5	R:R:W36	R:R:Y40	1.93	Yes	Yes	7	5	7
6	R:R:F91	R:R:W36	2	No	Yes	7	6	5
7	R:R:Q287	R:R:W36	9.86	No	Yes	0	1	5
8	R:R:L290	R:R:W36	15.94	Yes	Yes	7	4	5
9	R:R:A291	R:R:W36	2.59	No	Yes	0	5	5
10	R:R:A39	R:R:W294	2.59	No	No	0	5	5
11	R:R:F91	R:R:Y40	10.32	No	Yes	7	6	7
12	R:R:L290	R:R:Y40	5.86	Yes	Yes	7	4	7
13	R:R:F293	R:R:Y40	4.13	Yes	Yes	0	5	7
14	R:R:W294	R:R:Y40	3.86	No	Yes	0	5	7
15	R:R:L43	R:R:W294	10.25	No	No	0	7	5
16	R:R:A83	R:R:V44	1.7	No	No	0	6	6
17	R:R:M301	R:R:V46	3.04	No	No	0	7	5
18	R:R:A47	R:R:A83	1.79	No	No	0	8	6
19	R:R:A47	R:R:T300	3.36	No	No	0	8	9
20	R:R:L80	R:R:V48	2.98	No	No	0	7	6
21	R:R:A83	R:R:V48	1.7	No	No	0	6	6
22	R:R:G50	R:R:T49	3.64	No	No	0	8	4
23	R:R:G50	R:R:I53	1.76	No	No	0	8	6
24	R:R:G50	R:R:P304	2.03	No	No	0	8	9
25	R:R:D79	R:R:N51	6.73	Yes	No	0	9	9
26	R:R:N51	R:R:P304	9.77	No	No	0	9	9
27	R:R:A52	R:R:L80	4.73	No	No	0	4	7
28	R:R:I53	R:R:W56	5.87	No	No	0	6	4
29	R:R:H312	R:R:V54	6.92	Yes	No	0	5	9
30	R:R:I55	R:R:V73	4.61	No	No	0	7	6
31	R:R:A76	R:R:I55	4.87	No	No	0	9	7
32	R:R:I55	R:R:L77	2.85	No	No	0	7	7
33	R:R:H312	R:R:I57	11.93	Yes	No	0	5	8
34	R:R:I58	R:R:N69	5.66	No	Yes	0	7	8
35	R:R:I58	R:R:V73	4.61	No	No	0	7	6
36	R:R:L59	R:R:R65	6.07	No	No	0	4	6
37	R:R:M64	R:R:R62	7.44	No	No	0	8	6
38	R:R:R63	R:R:R65	3.2	No	No	0	5	6
39	R:R:M64	R:R:N69	11.22	No	Yes	0	8	8
40	R:R:R65	R:R:Y70	7.2	No	No	0	6	5
41	R:R:T66	R:R:V67	3.17	No	Yes	4	8	7
42	R:R:L143	R:R:T66	10.32	No	No	4	6	8
43	R:R:D130	R:R:V67	4.38	No	Yes	4	9	7
44	R:R:R142	R:R:V67	14.38	Yes	Yes	4	4	7
45	R:R:L143	R:R:V67	4.47	No	Yes	4	6	7
46	R:R:T148	R:R:V67	4.76	Yes	Yes	4	8	7
47	R:R:N69	R:R:T68	7.31	Yes	No	0	8	8
48	R:R:I72	R:R:N69	7.08	No	Yes	0	8	8
49	R:R:T148	R:R:Y70	4.99	Yes	No	0	8	5
50	R:R:A126	R:R:F71	8.32	No	Yes	0	7	7
51	R:R:F71	R:R:I127	2.51	Yes	Yes	0	7	8
52	R:R:F71	R:R:T148	2.59	Yes	Yes	0	7	8
53	R:R:F71	R:R:V151	3.93	Yes	No	0	7	5
54	R:R:F71	R:R:I152	6.28	Yes	No	0	7	7
55	R:R:I127	R:R:I72	2.94	Yes	No	2	8	8
56	R:R:I72	R:R:Y307	3.63	No	Yes	2	8	9
57	R:R:N74	R:R:S123	2.98	No	No	0	9	8
58	R:R:N74	R:R:W156	6.78	No	No	0	9	9
59	R:R:D79	R:R:L75	2.71	Yes	Yes	2	9	9
60	R:R:L75	R:R:S120	3	Yes	No	2	9	9
61	R:R:L75	R:R:S123	6.01	Yes	No	0	9	8
62	R:R:L75	R:R:N303	6.87	Yes	No	2	9	9
63	R:R:L75	R:R:Y307	2.34	Yes	Yes	2	9	9
64	R:R:A78	R:R:V119	1.7	No	No	0	8	7
65	R:R:A78	R:R:S120	3.42	No	No	0	8	9
66	R:R:D79	R:R:S120	7.36	Yes	No	2	9	9
67	R:R:D79	R:R:T300	10.12	Yes	No	0	9	9
68	R:R:D79	R:R:N303	5.39	Yes	No	2	9	9
69	R:R:C81	R:R:F85	5.59	No	Yes	3	6	4
70	R:R:C81	R:R:F112	4.19	No	Yes	3	6	5
71	R:R:A116	R:R:C81	1.81	No	No	0	8	6
72	R:R:M82	R:R:N86	5.61	Yes	Yes	0	7	6
73	R:R:A116	R:R:M82	3.22	No	Yes	0	8	7
74	R:R:M117	R:R:M82	2.89	Yes	Yes	0	7	7
75	R:R:M297	R:R:M82	2.89	No	Yes	0	7	7
76	R:R:A84	R:R:F85	4.16	No	Yes	0	5	4
77	R:R:F85	R:R:F89	4.29	Yes	No	3	4	5
78	R:R:F108	R:R:F85	4.29	No	Yes	3	4	4
79	R:R:F112	R:R:F85	3.22	Yes	Yes	3	5	4
80	R:R:N86	R:R:N90	4.09	Yes	Yes	0	6	6
81	R:R:N86	R:R:P113	8.15	Yes	No	0	6	7
82	R:R:F293	R:R:N86	3.62	Yes	Yes	0	5	6
83	R:R:F105	R:R:F89	11.79	Yes	No	3	6	5
84	R:R:F89	R:R:Q109	9.37	No	No	3	5	5
85	R:R:N90	R:R:Y93	2.33	Yes	Yes	0	6	4
86	R:R:N90	R:R:Q109	3.96	Yes	No	0	6	5
87	R:R:N90	R:R:Y289	2.33	Yes	Yes	0	6	3
88	R:R:F91	R:R:L290	4.87	No	Yes	7	6	4
89	R:R:V92	R:R:Y100	5.05	No	No	0	4	3
90	R:R:H96	R:R:Y93	6.53	No	Yes	0	4	4
91	R:R:T179	R:R:Y93	16.23	No	Yes	0	4	4
92	R:R:K180	R:R:Y93	2.39	No	Yes	5	4	4
93	L:L:V26	R:R:Y93	7.57	Yes	Yes	5	0	4
94	L:L:L28	R:R:Y93	2.34	No	Yes	5	0	4
95	R:R:A94	R:R:Y289	2.67	No	Yes	0	4	3
96	L:L:F25	R:R:H96	3.39	Yes	No	0	0	4
97	R:R:F101	R:R:W99	16.04	No	No	0	6	8
98	R:R:F101	R:R:M174	4.98	No	No	0	6	5
99	R:R:R103	R:R:Y107	2.06	No	No	0	2	6
100	R:R:F105	R:R:F108	3.22	Yes	No	3	6	4
101	R:R:F105	R:R:Q109	8.2	Yes	No	3	6	5
102	R:R:C106	R:R:S170	1.72	No	No	0	9	5
103	R:R:C106	R:R:V172	3.42	No	No	0	9	4
104	R:R:C106	R:R:T179	6.76	No	No	0	9	4
105	R:R:F108	R:R:F112	9.65	No	Yes	3	4	5
106	R:R:N110	R:R:Q166	10.56	No	No	5	4	4
107	R:R:N110	R:R:S170	5.96	No	No	0	4	5
108	R:R:C181	R:R:N110	3.15	Yes	No	5	9	4
109	R:R:L111	R:R:T115	2.95	Yes	Yes	3	6	6
110	R:R:L111	R:R:L160	5.54	Yes	No	3	6	3
111	R:R:L111	R:R:S164	3	Yes	No	0	6	4
112	R:R:C167	R:R:L111	9.52	No	Yes	0	4	6
113	R:R:F112	R:R:P113	4.33	Yes	No	0	5	7
114	R:R:F112	R:R:T115	3.89	Yes	Yes	3	5	6
115	R:R:F118	R:R:I114	5.02	Yes	No	1	7	4
116	R:R:A163	R:R:I114	3.25	No	No	1	7	4
117	L:L:M29	R:R:I114	5.83	Yes	No	1	0	4
118	R:R:A159	R:R:T115	3.36	No	Yes	0	8	6
119	R:R:L160	R:R:T115	7.37	No	Yes	3	3	6
120	R:R:F118	R:R:M117	7.46	Yes	Yes	1	7	7
121	R:R:M117	R:R:W263	5.82	Yes	Yes	1	7	9
122	R:R:M117	R:R:Y266	7.18	Yes	Yes	1	7	6
123	R:R:H267	R:R:M117	2.63	Yes	Yes	1	7	7
124	L:L:M29	R:R:M117	2.89	Yes	Yes	1	0	7
125	R:R:A163	R:R:F118	2.77	No	Yes	1	7	7
126	R:R:F118	R:R:V201	2.62	Yes	Yes	1	7	5
127	R:R:F118	R:R:I205	15.07	Yes	Yes	1	7	6
128	L:L:M29	R:R:F118	2.49	Yes	Yes	1	0	7
129	R:R:V119	R:R:W156	11.03	No	No	0	7	9
130	R:R:A159	R:R:V119	1.7	No	No	0	8	7
131	R:R:I121	R:R:I205	2.94	Yes	Yes	1	8	6
132	R:R:I121	R:R:P209	3.39	Yes	No	0	8	9
133	R:R:F259	R:R:I121	6.28	Yes	Yes	1	9	8
134	R:R:I121	R:R:W263	3.52	Yes	Yes	1	8	9
135	R:R:I155	R:R:Y122	3.63	No	Yes	0	7	5
136	R:R:P209	R:R:Y122	4.17	No	Yes	0	9	5
137	R:R:M124	R:R:N303	4.21	No	No	0	8	9
138	R:R:T125	R:R:V212	6.35	No	No	0	7	7
139	R:R:I127	R:R:R131	6.26	Yes	Yes	2	8	9
140	R:R:I127	R:R:Y307	3.63	Yes	Yes	2	8	9
141	R:R:A128	R:R:A216	1.79	No	No	0	9	7
142	R:R:A128	R:R:Y217	5.34	No	Yes	0	9	8
143	R:R:D130	R:R:R142	5.96	No	Yes	4	9	4
144	R:R:R131	R:R:Y217	5.14	Yes	Yes	2	9	8
145	R:R:M252	R:R:R131	6.2	Yes	Yes	2	7	9
146	R:R:R131	R:R:Y307	3.09	Yes	Yes	2	9	9
147	R:R:M133	R:R:Y132	3.59	No	Yes	6	5	8
148	R:R:V136	R:R:Y132	12.62	Yes	Yes	6	7	8
149	R:R:H137	R:R:Y132	4.36	Yes	Yes	6	6	8
150	R:R:V219	R:R:Y132	7.57	No	Yes	6	4	8
151	R:R:H137	R:R:M133	5.25	Yes	No	6	6	5
152	R:R:I135	R:R:V136	3.07	No	Yes	6	8	7
153	R:R:I135	R:R:T223	3.04	No	No	6	8	5
154	R:R:H137	R:R:V136	8.3	Yes	Yes	6	6	7
155	R:R:V136	R:R:V219	3.21	Yes	No	6	7	4
156	R:R:T223	R:R:V136	4.76	No	Yes	6	5	7
157	R:R:R142	R:R:T148	5.17	Yes	Yes	4	4	8
158	R:R:P146	R:R:S144	5.34	No	No	0	4	7
159	R:R:S144	R:R:S147	3.26	No	No	4	7	5
160	R:R:A145	R:R:P146	1.87	No	No	0	1	4
161	R:R:K149	R:R:T148	3	No	Yes	0	3	8
162	R:R:I152	R:R:K149	4.36	No	No	0	7	3
163	R:R:I152	R:R:W156	2.35	No	No	0	7	9
164	R:R:P165	R:R:S164	1.78	No	No	0	8	4
165	R:R:F168	R:R:S164	3.96	No	No	0	5	4
166	R:R:C181	R:R:Q166	4.58	Yes	No	5	9	4
167	R:R:Q166	R:R:V183	7.16	No	No	0	4	5
168	R:R:A184	R:R:Y169	2.67	No	No	0	4	4
169	R:R:T171	R:R:T173	3.14	No	No	0	4	3
170	R:R:T171	R:R:V182	6.35	No	No	0	4	4
171	R:R:K180	R:R:T173	7.51	No	No	0	4	3
172	L:L:H20	R:R:T173	2.74	No	No	0	0	3
173	L:L:V26	R:R:K180	6.07	Yes	No	5	0	4
174	L:L:V26	R:R:C181	1.71	Yes	Yes	5	0	9
175	L:L:L28	R:R:C181	6.35	No	Yes	5	0	9
176	R:R:L194	R:R:V183	8.94	No	No	0	5	5
177	R:R:P186	R:R:W185	4.05	No	No	0	7	6
178	R:R:K192	R:R:P186	3.35	No	No	0	1	7
179	R:R:K192	R:R:T193	4.5	No	No	0	1	3
180	R:R:H198	R:R:L194	2.57	Yes	No	0	5	5
181	R:R:L195	R:R:L199	2.77	No	No	0	3	4
182	R:R:H198	R:R:Y197	8.71	Yes	No	0	5	6
183	R:R:V201	R:R:Y197	6.31	Yes	No	0	5	6
184	R:R:F270	R:R:H198	9.05	Yes	Yes	0	6	5
185	R:R:H198	R:R:I271	2.65	Yes	No	0	5	6
186	R:R:I271	R:R:L199	2.85	No	No	0	6	4
187	R:R:I205	R:R:V201	6.14	Yes	Yes	1	6	5
188	R:R:H267	R:R:V201	2.77	Yes	Yes	1	7	5
189	R:R:H267	R:R:I202	6.63	Yes	No	0	7	5
190	R:R:F207	R:R:Y206	5.16	No	Yes	0	4	8
191	R:R:L210	R:R:Y206	3.52	No	Yes	0	6	8
192	R:R:W263	R:R:Y206	1.93	Yes	Yes	0	9	8
193	R:R:L264	R:R:Y206	19.93	No	Yes	0	6	8
194	R:R:F259	R:R:L210	7.31	Yes	No	0	9	6
195	R:R:A260	R:R:L210	3.15	No	No	0	6	6
196	R:R:F259	R:R:M213	7.46	Yes	No	0	9	8
197	R:R:F214	R:R:S218	3.96	No	No	0	5	3
198	R:R:M252	R:R:Y217	5.99	Yes	Yes	2	7	8
199	R:R:V256	R:R:Y217	2.52	No	Yes	0	7	8
200	R:R:G221	R:R:I220	3.53	No	No	0	5	8
201	R:R:F248	R:R:I220	2.51	Yes	No	0	7	8
202	R:R:G221	R:R:V249	1.84	No	No	0	5	6
203	R:R:L222	R:R:R226	6.07	No	No	0	3	4
204	R:R:L224	R:R:M245	4.24	No	No	0	8	7
205	R:R:F248	R:R:L224	3.65	Yes	No	2	7	8
206	R:R:L224	R:R:V249	4.47	No	No	2	8	6
207	R:R:R226	R:R:W225	3	No	No	0	4	5
208	R:R:M245	R:R:W225	2.33	No	No	0	7	5
209	R:R:H241	R:R:R227	3.39	No	No	0	4	6
210	R:R:H241	R:R:N238	5.1	No	No	0	4	2
211	R:R:L242	R:R:N238	2.75	No	No	0	4	2
212	R:R:Q243	R:R:R240	2.34	No	No	0	4	3
213	R:R:K246	R:R:Q243	4.07	No	No	0	5	4
214	R:R:K250	R:R:M245	2.88	No	No	0	6	7
215	R:R:C309	R:R:K247	3.23	No	No	0	6	8
216	R:R:K247	R:R:L310	4.23	No	No	0	8	7
217	R:R:F248	R:R:V249	6.55	Yes	No	2	7	6
218	R:R:F248	R:R:M252	2.49	Yes	Yes	2	7	7
219	R:R:K250	R:R:V253	3.04	No	No	0	6	5
220	R:R:M252	R:R:V255	4.56	Yes	No	0	7	8
221	R:R:I306	R:R:V255	3.07	No	No	0	8	8
222	R:R:T258	R:R:Y302	9.99	No	No	0	6	6
223	R:R:F259	R:R:W263	7.02	Yes	Yes	1	9	9
224	R:R:C262	R:R:L295	3.17	No	No	0	9	7
225	R:R:C262	R:R:S298	3.44	No	No	0	9	5
226	R:R:W263	R:R:Y266	3.86	Yes	Yes	1	9	6
227	R:R:H267	R:R:W263	3.17	Yes	Yes	1	7	9
228	R:R:A296	R:R:W263	3.89	No	Yes	1	7	9
229	R:R:S299	R:R:W263	7.41	No	Yes	0	9	9
230	R:R:L292	R:R:P265	8.21	No	No	0	7	9
231	R:R:H267	R:R:Y266	8.71	Yes	Yes	1	7	6
232	R:R:F270	R:R:Y266	11.35	Yes	Yes	1	6	6
233	R:R:F293	R:R:Y266	5.16	Yes	Yes	0	5	6
234	R:R:A296	R:R:Y266	5.34	No	Yes	1	7	6
235	L:L:M29	R:R:Y266	9.58	Yes	Yes	1	0	6
236	R:R:I271	R:R:L268	2.85	No	No	0	6	6
237	R:R:F270	R:R:Y269	3.09	Yes	Yes	1	6	4
238	R:R:Y269	R:R:Y280	4.96	Yes	No	1	4	1
239	R:R:I285	R:R:Y269	9.67	No	Yes	1	4	4
240	R:R:V288	R:R:Y269	2.52	No	Yes	0	5	4
241	R:R:Y269	R:R:Y289	16.88	Yes	Yes	1	4	3
242	L:L:F25	R:R:Y269	4.13	Yes	Yes	1	0	4
243	L:L:M29	R:R:F270	7.46	Yes	Yes	1	0	6
244	R:R:G273	R:R:L272	1.71	No	No	0	3	5
245	R:R:G273	R:R:Y280	5.79	No	No	0	3	1
246	R:R:H282	R:R:I279	13.26	No	No	0	1	3
247	R:R:I285	R:R:Y280	3.63	No	No	1	4	1
248	L:L:D23	R:R:C281	3.11	No	No	0	0	1
249	R:R:F284	R:R:H282	10.18	No	No	0	2	1
250	L:L:D23	R:R:K283	9.68	No	No	0	0	2
251	L:L:F25	R:R:I285	6.28	Yes	No	1	0	4
252	R:R:L290	R:R:Q286	5.32	Yes	No	0	4	4
253	L:L:F25	R:R:Q286	10.54	Yes	No	0	0	4
254	R:R:L292	R:R:V288	2.98	No	No	0	7	5
255	R:R:F293	R:R:Y289	10.32	Yes	Yes	0	5	3
256	L:L:F25	R:R:Y289	4.13	Yes	Yes	1	0	3
257	L:L:G27	R:R:Y289	7.24	No	Yes	1	0	3
258	R:R:F293	R:R:M297	7.46	Yes	No	0	5	7
259	R:R:M301	R:R:S298	3.07	No	No	8	7	5
260	R:R:S298	R:R:Y302	10.17	No	No	8	5	6
261	R:R:M301	R:R:Y302	8.38	No	No	8	7	6
262	R:R:I306	R:R:Y307	2.42	No	Yes	0	8	9
263	R:R:N311	R:R:Y307	5.81	No	Yes	0	8	9
264	R:R:C308	R:R:H312	7.37	No	Yes	0	7	5
265	R:R:H312	R:R:N311	3.83	Yes	No	0	5	8
266	L:L:K21	L:L:T22	4.5	No	No	0	0	0
267	L:L:D23	L:L:T22	2.89	No	No	0	0	0
268	L:L:F25	L:L:G27	3.01	Yes	No	1	0	0
269	L:L:L28	L:L:V26	2.98	No	Yes	5	0	0
270	R:R:M28	R:R:P29	1.68	Yes	No	0	4	3
271	R:R:A178	R:R:T179	1.68	No	No	0	3	4
272	R:R:A184	R:R:T193	1.68	No	No	0	4	3
273	R:R:L208	R:R:P209	1.64	No	No	0	5	9
274	R:R:C262	R:R:I261	1.64	No	No	0	9	6
275	R:R:L295	R:R:P265	1.64	No	No	0	7	9
276	R:R:C281	R:R:I279	1.64	No	No	0	1	3
277	L:L:S24	L:L:V26	1.62	No	Yes	0	0	0
278	R:R:G177	R:R:H96	1.59	No	No	0	5	4
279	R:R:T193	R:R:V183	1.59	No	No	0	3	5
280	R:R:P29	R:R:Q32	1.58	No	No	0	3	1
281	R:R:A37	R:R:L33	1.58	No	No	0	5	1
282	R:R:P141	R:R:Q140	1.58	No	No	0	6	5
283	R:R:A161	R:R:L162	1.58	No	No	0	3	5
284	R:R:A203	R:R:L204	1.58	No	No	0	4	4
285	R:R:M28	R:R:S95	1.53	Yes	No	0	4	4
286	R:R:H137	R:R:P138	1.53	Yes	No	0	6	8
287	R:R:M174	R:R:V172	1.52	No	No	0	5	4
288	R:R:I306	R:R:T251	1.52	No	No	0	8	8
289	R:R:F105	R:R:G102	1.51	Yes	No	0	6	8
290	R:R:L194	R:R:S274	1.5	No	No	0	5	4
291	R:R:L162	R:R:V158	1.49	No	No	0	5	4
292	R:R:L204	R:R:V200	1.49	No	No	0	4	3
293	R:R:L254	R:R:V255	1.49	No	No	0	5	8
294	R:R:L35	R:R:T38	1.47	No	No	0	4	5
295	R:R:L45	R:R:T49	1.47	No	No	0	5	4
296	R:R:I135	R:R:I220	1.47	No	No	0	8	8
297	R:R:I205	R:R:L162	1.43	Yes	No	0	6	5
298	R:R:L310	R:R:M252	1.41	No	Yes	0	7	7
299	R:R:A104	R:R:R103	1.38	No	No	0	2	2
300	R:R:M133	R:R:Q140	1.36	No	No	0	5	5
301	R:R:C167	R:R:Y107	1.34	No	No	0	4	6
302	R:R:H61	R:R:I57	1.33	No	No	0	5	8
303	R:R:L242	R:R:Q243	1.33	No	No	0	4	4
304	R:R:E277	R:R:L272	1.33	No	No	0	3	5
305	R:R:R142	R:R:S144	1.32	Yes	No	4	4	7
306	R:R:R142	R:R:S147	1.32	Yes	No	4	4	5
307	R:R:D175	R:R:Q176	1.31	No	No	0	2	4
308	R:R:F284	R:R:V288	1.31	No	No	0	2	5
309	R:R:T125	R:R:Y122	1.25	No	Yes	0	7	5
310	R:R:L204	R:R:Y122	1.17	No	Yes	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:M28	3.96	5	0	4
2	R:R:W36	6.464	5	7	5
3	R:R:Y40	5.22	5	7	7
4	R:R:V67	6.232	5	4	7
5	R:R:N69	7.8175	4	0	8
6	R:R:F71	4.726	5	0	7
7	R:R:L75	4.186	5	2	9
8	R:R:D79	6.462	5	2	9
9	R:R:M82	3.6525	4	0	7
10	R:R:F85	4.31	5	3	4
11	R:R:N86	5.3675	4	0	6
12	R:R:N90	3.1775	4	0	6
13	R:R:Y93	6.23167	6	5	4
14	R:R:F105	6.18	4	3	6
15	R:R:L111	5.2525	4	3	6
16	R:R:F112	5.056	5	3	5
17	R:R:T115	4.3925	4	3	6
18	R:R:M117	4.81167	6	1	7
19	R:R:F118	5.905	6	1	7
20	R:R:I121	4.0325	4	1	8
21	R:R:Y122	2.555	4	0	5
22	R:R:I127	3.835	4	2	8
23	R:R:R131	5.1725	4	2	9
24	R:R:Y132	7.035	4	6	8
25	R:R:V136	6.392	5	6	7
26	R:R:H137	4.86	4	6	6
27	R:R:R142	5.63	5	4	4
28	R:R:T148	4.102	5	4	8
29	R:R:C181	3.9475	4	5	9
30	R:R:H198	5.745	4	0	5
31	R:R:V201	4.46	4	1	5
32	R:R:I205	6.395	4	1	6
33	R:R:Y206	7.635	4	0	8
34	R:R:Y217	4.7475	4	2	8
35	R:R:F248	3.8	4	2	7
36	R:R:M252	4.13	5	2	7
37	R:R:F259	7.0175	4	1	9
38	R:R:W263	4.5775	8	1	9
39	R:R:Y266	7.31143	7	1	6
40	R:R:H267	4.782	5	1	7
41	R:R:Y269	6.875	6	1	4
42	R:R:F270	7.7375	4	1	6
43	R:R:Y289	7.26167	6	1	3
44	R:R:L290	7.9975	4	7	4
45	R:R:F293	6.138	5	0	5
46	R:R:Y307	3.48667	6	2	9
47	R:R:H312	7.5125	4	0	5
48	L:L:F25	5.24667	6	1	0
49	L:L:V26	3.99	5	5	0
50	L:L:M29	5.65	5	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M28	R:R:Q286	12.4177	6.8	Yes	No	0	4	4
2	R:R:F293	R:R:Y40	13.5652	4.13	Yes	Yes	0	5	7
3	R:R:F293	R:R:Y289	17.931	10.32	Yes	Yes	0	5	3
4	L:L:F25	R:R:Q286	10.3155	10.54	Yes	No	0	0	4
5	R:R:D79	R:R:S120	10.6491	7.36	Yes	No	2	9	9
6	R:R:A78	R:R:S120	46.2888	3.42	No	No	0	8	9
7	R:R:A78	R:R:V119	46.8195	1.7	No	No	0	8	7
8	R:R:A159	R:R:V119	97.2077	1.7	No	No	0	8	7
9	R:R:A159	R:R:T115	97.4825	3.36	No	Yes	0	8	6
10	R:R:F112	R:R:T115	100	3.89	Yes	Yes	3	5	6
11	R:R:F112	R:R:P113	83.0131	4.33	Yes	No	0	5	7
12	R:R:N86	R:R:P113	83.1221	8.15	Yes	No	0	6	7
13	R:R:N86	R:R:N90	32.2389	4.09	Yes	Yes	0	6	6
14	R:R:N90	R:R:Y289	18.3632	2.33	Yes	Yes	0	6	3
15	R:R:F293	R:R:N86	43.081	3.62	Yes	Yes	0	5	6
16	R:R:V288	R:R:Y269	20.1695	2.52	No	Yes	0	5	4
17	R:R:L292	R:R:V288	10.9071	2.98	No	No	0	7	5
18	R:R:L75	R:R:Y307	36.5145	2.34	Yes	Yes	2	9	9
19	R:R:L75	R:R:S120	35.2138	3	Yes	No	2	9	9
20	R:R:I72	R:R:N69	13.2883	7.08	No	Yes	0	8	8
21	R:R:F71	R:R:I127	30.5438	2.51	Yes	Yes	0	7	8
22	R:R:F71	R:R:I152	38.7005	6.28	Yes	No	0	7	7
23	R:R:I152	R:R:W156	48.9951	2.35	No	No	0	7	9
24	R:R:V119	R:R:W156	50.4636	11.03	No	No	0	7	9
25	R:R:F71	R:R:T148	11.9267	2.59	Yes	Yes	0	7	8
26	R:R:I152	R:R:K149	10.1582	4.36	No	No	0	7	3
27	R:R:C81	R:R:F112	15.2541	4.19	No	Yes	3	6	5
28	R:R:A116	R:R:C81	15.7009	1.81	No	No	0	8	6
29	R:R:A116	R:R:M82	15.9841	3.22	No	Yes	0	8	7
30	R:R:M82	R:R:N86	17.0121	5.61	Yes	Yes	0	7	6
31	R:R:F293	R:R:Y266	22.6807	5.16	Yes	Yes	0	5	6
32	R:R:W263	R:R:Y266	14.4485	3.86	Yes	Yes	1	9	6
33	R:R:I121	R:R:W263	15.1995	3.52	Yes	Yes	1	8	9
34	R:R:I121	R:R:P209	14.1589	3.39	Yes	No	0	8	9
35	R:R:P209	R:R:Y122	11.0414	4.17	No	Yes	0	9	5
36	R:R:R131	R:R:Y307	23.1444	3.09	Yes	Yes	2	9	9
37	R:R:I127	R:R:R131	22.7772	6.26	Yes	Yes	2	8	9
38	R:R:M252	R:R:R131	39.4537	6.2	Yes	Yes	2	7	9
39	R:R:F248	R:R:M252	34.7522	2.49	Yes	Yes	2	7	7
40	R:R:F248	R:R:I220	21.2793	2.51	Yes	No	0	7	8
41	R:R:I135	R:R:I220	18.6632	1.47	No	No	0	8	8
42	R:R:I135	R:R:V136	15.8289	3.07	No	Yes	6	8	7
43	R:R:Y269	R:R:Y289	20.9457	16.88	Yes	Yes	1	4	3
44	R:R:N90	R:R:Y93	20.3017	2.33	Yes	Yes	0	6	4
45	R:R:M117	R:R:M82	30.099	2.89	Yes	Yes	0	7	7
46	R:R:M117	R:R:W263	17.0247	5.82	Yes	Yes	1	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:M28	R:R:Q286	6.8	0	Yes	No	4	4	2	1
R:R:M117	R:R:M82	2.89	1	Yes	Yes	7	7	1	2
R:R:N90	R:R:Y93	2.33	0	Yes	Yes	6	4	2	1
R:R:N90	R:R:Y289	2.33	0	Yes	Yes	6	3	2	1
R:R:H96	R:R:Y93	6.53	0	No	Yes	4	4	1	1
R:R:T179	R:R:Y93	16.23	0	No	Yes	4	4	2	1
R:R:K180	R:R:Y93	2.39	5	No	Yes	4	4	1	1
L:L:V26	R:R:Y93	7.57	5	Yes	Yes	0	4	0	1
L:L:L28	R:R:Y93	2.34	5	No	Yes	0	4	0	1
R:R:A94	R:R:Y289	2.67	0	No	Yes	4	3	2	1
L:L:F25	R:R:H96	3.39	1	Yes	No	0	4	0	1
R:R:N110	R:R:Q166	10.56	5	No	No	4	4	2	2
R:R:C181	R:R:N110	3.15	5	Yes	No	9	4	1	2
R:R:F118	R:R:I114	5.02	1	Yes	No	7	4	1	1
R:R:A163	R:R:I114	3.25	1	No	No	7	4	2	1
L:L:M29	R:R:I114	5.83	1	Yes	No	0	4	0	1
R:R:F118	R:R:M117	7.46	1	Yes	Yes	7	7	1	1
R:R:M117	R:R:W263	5.82	1	Yes	Yes	7	9	1	2
R:R:M117	R:R:Y266	7.18	1	Yes	Yes	7	6	1	1
R:R:H267	R:R:M117	2.63	1	Yes	Yes	7	7	2	1
L:L:M29	R:R:M117	2.89	1	Yes	Yes	0	7	0	1
R:R:A163	R:R:F118	2.77	1	No	Yes	7	7	2	1
R:R:F118	R:R:V201	2.62	1	Yes	Yes	7	5	1	2
R:R:F118	R:R:I205	15.07	1	Yes	Yes	7	6	1	2
L:L:M29	R:R:F118	2.49	1	Yes	Yes	0	7	0	1
R:R:C181	R:R:Q166	4.58	5	Yes	No	9	4	1	2
R:R:T171	R:R:T173	3.14	0	No	No	4	3	2	1
R:R:K180	R:R:T173	7.51	5	No	No	4	3	1	1
L:L:H20	R:R:T173	2.74	0	No	No	0	3	0	1
L:L:V26	R:R:K180	6.07	5	Yes	No	0	4	0	1
L:L:V26	R:R:C181	1.71	5	Yes	Yes	0	9	0	1
L:L:L28	R:R:C181	6.35	5	No	Yes	0	9	0	1
R:R:F270	R:R:H198	9.05	1	Yes	Yes	6	5	1	2
R:R:I205	R:R:V201	6.14	1	Yes	Yes	6	5	2	2
R:R:H267	R:R:V201	2.77	1	Yes	Yes	7	5	2	2
R:R:W263	R:R:Y266	3.86	1	Yes	Yes	9	6	2	1
R:R:H267	R:R:W263	3.17	1	Yes	Yes	7	9	2	2
R:R:A296	R:R:W263	3.89	1	No	Yes	7	9	2	2
R:R:H267	R:R:Y266	8.71	1	Yes	Yes	7	6	2	1
R:R:F270	R:R:Y266	11.35	1	Yes	Yes	6	6	1	1
R:R:F293	R:R:Y266	5.16	0	Yes	Yes	5	6	2	1
R:R:A296	R:R:Y266	5.34	1	No	Yes	7	6	2	1
L:L:M29	R:R:Y266	9.58	1	Yes	Yes	0	6	0	1
R:R:F270	R:R:Y269	3.09	1	Yes	Yes	6	4	1	1
R:R:Y269	R:R:Y280	4.96	1	Yes	No	4	1	1	2
R:R:I285	R:R:Y269	9.67	1	No	Yes	4	4	1	1
R:R:V288	R:R:Y269	2.52	0	No	Yes	5	4	2	1
R:R:Y269	R:R:Y289	16.88	1	Yes	Yes	4	3	1	1
L:L:F25	R:R:Y269	4.13	1	Yes	Yes	0	4	0	1
L:L:M29	R:R:F270	7.46	1	Yes	Yes	0	6	0	1
R:R:I285	R:R:Y280	3.63	1	No	No	4	1	1	2
L:L:D23	R:R:C281	3.11	0	No	No	0	1	0	1
L:L:D23	R:R:K283	9.68	0	No	No	0	2	0	1
L:L:F25	R:R:I285	6.28	1	Yes	No	0	4	0	1
R:R:L290	R:R:Q286	5.32	7	Yes	No	4	4	2	1
L:L:F25	R:R:Q286	10.54	1	Yes	No	0	4	0	1
R:R:F293	R:R:Y289	10.32	0	Yes	Yes	5	3	2	1
L:L:F25	R:R:Y289	4.13	1	Yes	Yes	0	3	0	1
L:L:G27	R:R:Y289	7.24	1	No	Yes	0	3	0	1
R:R:C281	R:R:I279	1.64	0	No	No	1	3	1	2
R:R:G177	R:R:H96	1.59	0	No	No	5	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XWO_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.7
Number of Linked Nodes	253
Number of Links	310
Number of Hubs	50
Number of Links mediated by Hubs	178
Number of Communities	8
Number of Nodes involved in Communities	72
Number of Links involved in Communities	108

Path Summary
Number Of Nodes in MetaPath	47
Number Of Links MetaPath	46
Number of Shortest Paths	69655
Length Of Smallest Path	3
Average Path Length	15.4566
Length of Longest Path	31
Minimum Path Strength	1.21
Average Path Strength	4.62615
Maximum Path Strength	12.545
Minimum Path Correlation	0.7
Average Path Correlation	0.923203
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	43.3904
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.9455
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • multicellular organismal process • response to stress • multicellular organismal response to stress • response to pain • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • system process • circulatory system process • regulation of blood pressure • blood circulation • detection of stimulus • response to abiotic stimulus • detection of abiotic stimulus • regulation of defense response • regulation of response to external stimulus • defense response • positive regulation of biological process • response to external stimulus • regulation of inflammatory response • positive regulation of acute inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stimulus • regulation of response to stress • positive regulation of defense response • regulation of acute inflammatory response • inflammatory response • acute inflammatory response • positive regulation of cell communication • modulation of chemical synaptic transmission • positive regulation of synaptic transmission, GABAergic • synaptic signaling • positive regulation of cellular process • trans-synaptic signaling • regulation of signaling • synaptic transmission, GABAergic • positive regulation of synaptic transmission • cell-cell signaling • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • positive regulation of signaling • regulation of synaptic transmission, GABAergic • cellular response to endogenous stimulus • cellular response to growth factor stimulus • response to endogenous stimulus • cellular response to nerve growth factor stimulus • response to nerve growth factor • response to growth factor • behavior • learning or memory • long-term memory • nervous system process • cognition • memory • regulation of action potential • positive regulation of action potential • action potential • regulation of membrane potential • positive regulation of cell population proliferation • regulation of leukocyte activation • regulation of cell activation • lymphocyte activation • leukocyte proliferation • leukocyte activation • positive regulation of lymphocyte activation • positive regulation of cell activation • lymphocyte proliferation • positive regulation of leukocyte activation • positive regulation of mononuclear cell proliferation • regulation of immune system process • regulation of multicellular organismal process • positive regulation of immune system process • regulation of lymphocyte proliferation • regulation of leukocyte proliferation • cell population proliferation • cell activation • positive regulation of lymphocyte proliferation • regulation of cell population proliferation • mononuclear cell proliferation • immune system process • positive regulation of leukocyte proliferation • regulation of mononuclear cell proliferation • positive regulation of multicellular organismal process • regulation of lymphocyte activation • learning • associative learning • ossification • positive regulation of ossification • regulation of ossification • tachykinin receptor signaling pathway • sensory perception • sensory perception of pain • heart process • negative regulation of heart rate • regulation of heart contraction • regulation of system process • negative regulation of biological process • negative regulation of blood circulation • negative regulation of heart contraction • regulation of blood circulation • heart contraction • negative regulation of multicellular organismal process • regulation of heart rate • positive regulation of synaptic transmission, cholinergic • synaptic transmission, cholinergic • regulation of synaptic transmission, cholinergic • multi-multicellular organism process • reproductive process • multicellular organismal reproductive process • reproductive behavior • insemination • mating behavior • multi-organism reproductive process • copulation • regulation of localization • corticosterone secretion • positive regulation of steroid hormone secretion • localization • regulation of glucocorticoid secretion • positive regulation of glucocorticoid secretion • regulation of steroid hormone secretion • positive regulation of corticosteroid hormone secretion • regulation of hormone levels • lipid transport • regulation of corticosteroid hormone secretion • establishment of localization • regulation of secretion • endocrine hormone secretion • positive regulation of lipid transport • lipid export from cell • glucocorticoid secretion • regulation of endocrine process • corticosteroid hormone secretion • regulation of corticosterone secretion • regulation of hormone secretion • transport • steroid hormone secretion • regulation of lipid transport • positive regulation of secretion by cell • organic hydroxy compound transport • hormone secretion • positive regulation of corticosterone secretion • secretion by cell • positive regulation of hormone secretion • regulation of secretion by cell • positive regulation of secretion • signal release • secretion • regulation of transport • lipid localization • export from cell • positive regulation of lipid localization • endocrine process • positive regulation of transport • regulation of lipid localization • macromolecule localization • hormone transport • biological process involved in interspecies interaction between organisms • response to lipid • response to other organism • response to oxygen-containing compound • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to chemical • response to external biotic stimulus • response to molecule of bacterial origin • positive regulation of organelle organization • regulation of cytoskeleton organization • regulation of cellular component organization • regulation of actin filament-based process • positive regulation of cellular component organization • regulation of actin filament bundle assembly • cellular component biogenesis • cellular component organization • cellular component assembly • positive regulation of actin filament bundle assembly • actin filament bundle organization • positive regulation of stress fiber assembly • actin filament-based process • cellular component organization or biogenesis • stress fiber assembly • regulation of actin filament organization • actin cytoskeleton organization • actomyosin structure organization • positive regulation of cellular component biogenesis • positive regulation of cytoskeleton organization • actin filament organization • regulation of cellular component biogenesis • positive regulation of supramolecular fiber organization • regulation of organelle organization • regulation of stress fiber assembly • organelle organization • contractile actin filament bundle assembly • regulation of actomyosin structure organization • regulation of actin cytoskeleton organization • actin filament bundle assembly • regulation of supramolecular fiber organization • supramolecular fiber organization • cytoskeleton organization • response to hormone • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • positive regulation of epithelial cell migration • tissue migration • ameboidal-type cell migration • positive regulation of cell motility • regulation of cell migration • cell migration • epithelial cell migration • cell motility • regulation of epithelial cell migration • locomotion • epithelium migration • regulation of locomotion • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cellular anatomical structure • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cellular anatomical structure • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • extracellular region • synapse • cell junction • somatodendritic compartment • cell body • neuronal cell body • axon • cell projection • neuron projection • plasma membrane bounded cell projection • extracellular space • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cell periphery • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • dendrite • dendritic tree • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • substance K receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • tachykinin receptor activity • neuropeptide receptor activity • electron transport chain • metabolic process • generation of precursor metabolites and energy • response to electrical stimulus • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • positive regulation of biological process • establishment of localization • localization • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • establishment of protein localization • nitrogen compound transport • hormone secretion • protein localization to extracellular region • peptide secretion • secretion by cell • amide transport • signal release • intracellular protein localization • secretion • regulation of hormone levels • prolactin secretion • establishment of protein localization to extracellular region • cell-cell signaling • export from cell • protein secretion • peptide transport • protein transport • peptide hormone secretion • macromolecule localization • hormone transport • intestine smooth muscle contraction • gastro-intestinal system smooth muscle contraction • smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • muscle system process • positive regulation of cell communication • positive regulation of neurotransmitter secretion • positive regulation of amine transport • acetylcholine secretion, neurotransmission • establishment of localization in cell • positive regulation of acetylcholine secretion, neurotransmission • trans-synaptic signaling • positive regulation of neurotransmitter transport • positive regulation of synaptic transmission, cholinergic • neurotransmitter secretion • positive regulation of synaptic transmission • regulation of acetylcholine secretion, neurotransmission • neurotransmitter transport • organic cation transport • acetate ester transport • regulation of secretion • signal release from synapse • acetylcholine transport • regulation of trans-synaptic signaling • cellular localization • modulation of chemical synaptic transmission • positive regulation of secretion by cell • synaptic signaling • regulation of secretion by cell • positive regulation of secretion • acetylcholine secretion • positive regulation of cellular process • regulation of signaling • regulation of neurotransmitter transport • chemical synaptic transmission • amine transport • regulation of neurotransmitter secretion • anterograde trans-synaptic signaling • regulation of cell communication • synaptic transmission, cholinergic • regulation of amine transport • regulation of synaptic transmission, cholinergic • positive regulation of signaling • positive regulation of locomotion • regulation of cell motility • regulation of reproductive process • reproductive process • regulation of cilium-dependent cell motility • positive regulation of flagellated sperm motility • cilium or flagellum-dependent cell motility • regulation of flagellated sperm motility • cilium-dependent cell motility • positive regulation of cell motility • positive regulation of cilium movement • cell motility • locomotion • positive regulation of reproductive process • sperm motility • positive regulation of cilium-dependent cell motility • regulation of microtubule-based process • regulation of microtubule-based movement • cilium movement involved in cell motility • regulation of cilium movement • regulation of locomotion • flagellated sperm motility • microtubule-based movement • microtubule-based process • cilium movement • regulation of cilium movement involved in cell motility • regulation of vascular permeability • circulatory system process • positive regulation of vascular permeability • vascular process in circulatory system • blood circulation • positive regulation of smooth muscle contraction • regulation of system process • regulation of muscle system process • regulation of muscle contraction • regulation of smooth muscle contraction • positive regulation of muscle contraction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • negative regulation of luteinizing hormone secretion • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • regulation of luteinizing hormone secretion • luteinizing hormone secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • endocrine hormone secretion • negative regulation of gonadotropin secretion • negative regulation of multicellular organismal process • regulation of endocrine process • regulation of hormone secretion • gonadotropin secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of cellular process • regulation of gonadotropin secretion • endocrine process • positive regulation of uterine smooth muscle contraction • uterine smooth muscle contraction • regulation of uterine smooth muscle contraction • tachykinin receptor signaling pathway • behavior • learning • learning or memory • cognition • operant conditioning • periplasmic space • 9+2 motile cilium • sperm flagellum • motile cilium • sperm midpiece • sperm head
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21452
Sequence	>7XWO_nogp_Chain_R S M P S W Q L A L W A T A Y L A L V L V A V T G N A I V I W I I L A H R R M R T V T N Y F I V N L A L A D L C M A A F N A A F N F V Y A S H W Y F G R A F C Y F Q N L F P I T A M F V S I Y S M T A I A A D R Y M A I V H P F Q P R L S A P S T K A V I A G I W L V A L A L A S P Q C F Y S T V T M D Q G A T K C V V A W P G K T L L L Y H L V V I A L I Y F L P L A V M F V A Y S V I G L T L W R R N L R H L Q A M K K F V K T M V L V V L T F A I C W L P Y H L Y F I L G S F Q E D I Y C H K F I Q Q V Y L A L F W L A M S S T M Y N P I I Y C C L N H R F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XWO	A	Peptide	Tachykinin	NK₂	Homo sapiens	Neurokinin-A	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.7	2023-05-31	doi.org/10.1038/s41421-022-00437-8
	7XWO (No Gprot)	A	Peptide	Tachykinin	NK₂	Homo sapiens	Neurokinin-A	-		2.7	2023-05-31	doi.org/10.1038/s41421-022-00437-8

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