Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 4.888525
2A:A:L37 4.608519
3A:A:K46 4.43167629
4A:A:M53 6.8275428
5A:A:F191 7.33425
6A:A:L194 4.798524
7A:A:F196 6.756527
8A:A:K197 6.9325416
9A:A:M198 3.68667627
10A:A:F199 8.014515
11A:A:D200 2.9125429
12A:A:V201 3.328519
13A:A:R208 4.204509
14A:A:K210 4.984519
15A:A:W211 4.9625419
16A:A:H213 5.55254128
17A:A:F215 3.97625819
18A:A:L227 5.72447
19A:A:Y230 5.616548
20A:A:F250 4.90857749
21A:A:C254 3.992545
22A:A:W258 8.215125
23A:A:F259 4.4125409
24A:A:I265 3.195408
25A:A:L266 3.6449
26A:A:F267 4.4225409
27A:A:L268 4.91448
28A:A:F274 7.7975449
29A:A:Y290 5.3054147
30A:A:E298 4.75754144
31A:A:F307 3.61548
32A:A:I319 5.565445
33A:A:Y320 9.363336167
34A:A:H322 7.985429
35A:A:F323 5.355444
36A:A:K330 6.99424
37A:A:N331 7.756528
38A:A:F336 4.49167628
39A:A:L348 3.286539
40A:A:L353 5.09437
41A:A:F354 5.48405
42B:B:L14 4.42408
43B:B:L30 3.32405
44B:B:V40 4.0425153
45B:B:M45 4.6175404
46B:B:L51 6.118579
47B:B:H54 7.93679
48B:B:Y59 7.52254128
49B:B:W63 5.666507
50B:B:L70 4.228575
51B:B:V71 4.685488
52B:B:D76 4.812579
53B:B:L79 4.8875407
54B:B:I81 3.52487
55B:B:W82 8.80833679
56B:B:Y85 11.04754264
57B:B:N88 4.365217
58B:B:K89 6.49857779
59B:B:H91 4.254585
60B:B:I93 5.0475487
61B:B:W99 7.802519
62B:B:Y105 4.07833686
63B:B:N110 6.19494
64B:B:Y111 5.402594
65B:B:C121 3418
66B:B:I123 3.564596
67B:B:Y124 5.775686
68B:B:T128 4.8875493
69B:B:V133 5.025484
70B:B:H142 6.96333619
71B:B:Y145 6.205618
72B:B:L146 3.8225417
73B:B:R150 5.3825456
74B:B:F151 4.0575499
75B:B:L152 4.2325403
76B:B:I157 2.9775497
77B:B:T159 6.0875419
78B:B:S160 3.6375456
79B:B:S161 7.435419
80B:B:D163 8.66419
81B:B:T165 4.0625417
82B:B:C166 3.2725458
83B:B:W169 11.4075408
84B:B:Q176 7.1525404
85B:B:F180 6.05333657
86B:B:H183 6.01167659
87B:B:D186 5.738519
88B:B:V187 4.086559
89B:B:L190 3.344555
90B:B:F199 6.33667659
91B:B:V200 4.3875466
92B:B:S201 4.6075459
93B:B:C204 5.5075417
94B:B:D205 5.028559
95B:B:K209 6.976556
96B:B:L210 4.382505
97B:B:W211 8.40667658
98B:B:E215 6.0354283
99B:B:Q220 6.428567
100B:B:H225 8.76833669
101B:B:D228 7.21419
102B:B:I232 4.096568
103B:B:F234 4.96465
104B:B:F235 6.5356186
105B:B:F241 5.868566
106B:B:T243 5.405468
107B:B:D247 5.826569
108B:B:R251 9.214568
109B:B:F253 7.1775466
110B:B:R256 6.4125409
111B:B:D258 10.0875467
112B:B:Y264 4.891437255
113B:B:F278 4.6265187
114B:B:R283 6.265717159
115B:B:L284 4.29254155
116B:B:L286 3.2785297
117B:B:Y289 6.27833607
118B:B:D290 6.9854126
119B:B:N295 6.2754196
120B:B:K301 5.5875405
121B:B:R304 7.27254195
122B:B:V307 3.0045193
123B:B:H311 7.0825139
124B:B:R314 10.2654128
125B:B:L318 3.68254296
126B:B:W332 8.993336129
127B:B:D333 5.315139
128B:B:F335 6.57754134
129B:B:K337 8.54754136
130B:B:W339 9.445139
131B:B:N340 6.11409
132G:G:R27 5.9825408
133G:G:D48 5.54833609
134G:G:L51 2.9556156
135G:G:F61 4.15268
136R:R:Y66 7.335118
137R:R:D69 4.38754317
138R:R:F70 3.264327
139R:R:R86 4.4054334
140R:R:T92 5.9554177
141R:R:P93 5.10754176
142R:R:N95 3.28407
143R:R:H100 6.764539
144R:R:L101 4.356539
145R:R:D105 6.295439
146R:R:L106 2.4925407
147R:R:R115 8.46117
148R:R:H119 7.248336115
149R:R:F127 6.635107
150R:R:F137 3.9085106
151R:R:F139 6.1254117
152R:R:Y140 9.7275404
153R:R:M143 5.374118
154R:R:Y144 5.3625407
155R:R:F149 4.875638
156R:R:R157 6.425439
157R:R:F158 6.0765348
158R:R:R171 7.855176
159R:R:W184 5.00333639
160R:R:M191 4.02254106
161R:R:L194 4.354104
162R:R:Q199 7.3654104
163R:R:Q211 8.4365104
164R:R:Y213 9.1025115
165R:R:F229 9.4254208
166R:R:F233 3.324206
167R:R:T236 5.9975438
168R:R:Y240 6.12167639
169R:R:I265 5.255407
170R:R:V277 2.9685205
171R:R:Y279 6.3665117
172R:R:Y286 10.2825354
173R:R:Y290 12.04254353
174R:R:R308 14.595113
175R:R:S311 4.054116
176R:R:T314 3.5154118
177R:R:L316 4.89254315
178R:R:D321 6.2875439
179R:R:M324 2.4525437
180R:R:Y325 4.65429739
181R:R:F326 6.34506
182R:R:F327 4.7925407
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:I221 A:A:L37 37.98012.85NoYes089
2A:A:F259 A:A:I221 37.80675.02YesNo098
3A:A:F259 A:A:N256 67.22362.42YesNo098
4A:A:K257 A:A:N256 67.11164.2NoNo048
5A:A:K257 A:A:W258 66.999515.08NoYes045
6A:A:W258 B:B:R314 41.86325YesYes1258
7B:B:R314 B:B:T274 28.88582.59YesNo1288
8B:B:S275 B:B:T274 29.11663.2NoNo088
9B:B:L318 B:B:S275 28.97916.01YesNo068
10B:B:L286 B:B:L318 17.66062.77YesYes2976
11B:B:L286 B:B:V327 13.4054.47YesNo076
12B:B:V327 G:G:L50 13.27412.98NoNo069
13B:B:M45 G:G:L50 10.90224.24YesNo049
14B:B:M45 B:B:N340 40.63294.21YesYes049
15B:B:N340 G:G:F61 36.9972.42YesYes098
16B:B:L318 B:B:T329 11.10642.95YesNo068
17B:B:T329 B:B:W339 21.61487.28NoYes089
18B:B:L308 B:B:W339 31.534220.5NoYes079
19B:B:L308 B:B:M45 31.10075.65NoYes074
20A:A:W258 B:B:W332 24.07933.75YesYes1259
21B:B:N313 B:B:W332 23.86245.65NoYes079
22B:B:D333 B:B:N313 23.59194.04YesNo097
23B:B:D333 B:B:H311 22.40972.52YesYes1399
24B:B:H311 B:B:T329 11.01096.85YesNo098
25B:B:H311 B:B:K337 11.08696.55YesYes1396
26B:B:K337 B:B:W339 10.84838.12YesYes1369
27A:A:L37 A:A:V201 38.60872.98YesYes199
28A:A:G202 A:A:V201 1001.84NoYes099
29A:A:D200 A:A:G202 99.96133.35YesNo099
30A:A:D200 A:A:L38 98.8954.07YesNo298
31A:A:L38 A:A:M198 99.48525.65NoYes287
32A:A:L36 A:A:M198 49.02142.83NoYes077
33A:A:L36 A:A:V34 47.20142.98NoYes075
34A:A:F189 A:A:M198 46.57686.22NoYes297
35A:A:F189 A:A:F196 46.914916.08NoYes297
36A:A:V339 A:A:V34 45.51978.02NoYes285
37A:A:F196 A:A:V339 45.9583.93YesNo278
38A:A:I212 A:A:R208 29.7463.76NoYes089
39A:A:F259 A:A:I212 29.6415.02YesNo098
40A:A:F223 A:A:F250 15.70869.65NoYes099
41A:A:R208 A:A:W211 31.93576YesYes099
42A:A:S206 A:A:W211 85.52863.71NoYes189
43A:A:S206 B:B:Y145 42.79295.09NoYes188
44B:B:G162 B:B:Y145 42.09328.69NoYes198
45B:B:G162 B:B:S161 83.95323.71NoYes199
46A:A:S206 B:B:D186 42.67542.94NoYes189
47B:B:D186 B:B:G162 42.06323.35YesNo199
48A:A:I343 A:A:V339 91.28143.07NoNo078
49A:A:I343 A:A:N347 91.0854.25NoNo078
50A:A:N347 R:R:A160 90.88834.69NoNo088
51R:R:A160 R:R:R171 90.49456.91NoYes086
52R:R:P93 R:R:R171 88.9910.09YesYes1766
53R:R:A176 R:R:P93 88.91331.87NoYes076
54R:R:A176 R:R:F97 37.99592.77NoNo077
55R:R:F97 R:R:I153 37.55633.77NoNo079
56R:R:I153 R:R:R157 18.78536.26NoYes399
57R:R:I153 R:R:Y325 18.56796.04NoYes399
58R:R:R157 R:R:Y240 11.38578.23YesYes399
59B:B:H142 B:B:S161 81.785115.34YesYes199
60B:B:H142 B:B:L146 35.51662.57YesYes197
61B:B:C121 B:B:L146 35.0783.17YesYes187
62B:B:C121 B:B:C149 69.85543.64YesNo188
63B:B:C149 B:B:T102 69.4143.38NoNo088
64B:B:C148 B:B:T102 68.95823.38NoNo068
65B:B:C148 B:B:L190 67.34883.17NoYes565
66B:B:F199 B:B:L190 54.92783.65YesYes595
67B:B:F199 B:B:W211 45.129417.04YesYes598
68B:B:K209 B:B:W211 39.64385.8YesYes568
69B:B:K209 B:B:T221 38.821312.01YesNo067
70B:B:T221 G:G:E22 38.35415.64NoNo079
71B:B:H142 B:B:T159 44.62186.85YesYes199
72B:B:C121 B:B:T159 35.70413.38YesYes189
73B:B:Q220 G:G:E22 32.26742.55YesNo079
74B:B:L51 B:B:W82 17.713413.67YesYes799
75B:B:I338 B:B:L51 21.93794.28NoYes059
76B:B:I338 G:G:F61 24.37523.77NoYes058
77B:B:L190 B:B:S160 10.33073YesYes556
78B:B:L210 B:B:Q220 12.84335.32YesYes057
79B:B:F222 B:B:Q220 11.39517.03NoYes687
80B:B:F222 B:B:F241 10.94578.57NoYes686
81B:B:C271 B:B:D290 13.10016.22NoYes056
82B:B:C271 B:B:Y289 12.13314.03NoYes057
83R:R:A176 R:R:V96 50.79755.09NoNo077
84R:R:H100 R:R:V96 50.36522.77YesNo097
85R:R:H100 R:R:W184 41.85746.35YesYes399
86R:R:L141 R:R:W184 41.30544.56NoYes059
87R:R:F137 R:R:L141 40.84453.65YesNo065
88R:R:F137 R:R:M191 29.96782.49YesYes1066
89R:R:M191 R:R:Y140 24.92277.18YesYes064
90R:R:F139 R:R:Y140 17.59736.19YesYes074
91R:R:F139 R:R:R115 11.721111.76YesYes1177
92R:R:L106 R:R:N77 14.1532.75YesNo079
93R:R:L106 R:R:V109 12.36082.98YesNo076
94R:R:F70 R:R:V109 10.96682.62YesNo3276
95R:R:D321 R:R:Y325 11.71775.75YesYes399
96B:B:D290 B:B:R314 13.045915.48YesYes1268
97A:A:V201 A:A:W211 53.79646.13YesYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7Y89
Class A
SubFamily Orphan
Type Orphan
SubType GPR17 (CysLT)
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.02
Date 2022-10-12
D.O.I. 10.1002/mco2.159
Net Summary
Imin 2.38
Number of Linked Nodes 829
Number of Links 1040
Number of Hubs 182
Number of Links mediated by Hubs 667
Number of Communities 35
Number of Nodes involved in Communities 275
Number of Links involved in Communities 383
Path Summary
Number Of Nodes in MetaPath 98
Number Of Links MetaPath 97
Number of Shortest Paths 2012559
Length Of Smallest Path 3
Average Path Length 33.7094
Length of Longest Path 55
Minimum Path Strength 1.275
Average Path Strength 5.48812
Maximum Path Strength 23.635
Minimum Path Correlation 0.7
Average Path Correlation 0.984445
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.77778
Average % Of Corr. Nodes 40.0187
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.441
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • G protein-coupled chemoattractant receptor activity   • molecular transducer activity   • chemokine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • cytokine receptor activity   • immune receptor activity   • receptor serine/threonine kinase binding   • signaling receptor binding   • cellular developmental process   • nervous system development   • neurogenesis   • central nervous system development   • gliogenesis   • oligodendrocyte differentiation   • glial cell differentiation   • cell differentiation   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • response to stress   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7Y89_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKST 
IVKQMTGIV ETHFTFKDL HFKMFDVGA QRSERKKWI HCFEGVTAI 
IFCVALSDY DLVNRMHES MKLFDSICN NKWFTDTSI ILFLNKKDL 
FEEKIKKSP LTICYPEYA GSNTYEEAA AYIQCQFED LNKRKDTKE 
IYTHFTCST DTKNVQFVF DAVTDVIIK NNLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7Y89_Chain_B
EAEQLKNQI RDARKACAD ATLSQITNN IDPVGRIQM RTRRTLRGH 
LAKIYAMHW GTDSRLLVS ASQDGKLII WDSYTTNKV HAIPLRSSW 
VMTCAYAPS GNYVACGGL DNICSIYNL KTREGNVRV SRELAGHTG 
YLSCCRFLD DNQIVTSSG DTTCALWDI ETGQQTTTF TGHTGDVMS 
LSLAPDTRL FVSGACDAS AKLWDVREG MCRQTFTGH ESDINAICF 
FPNGNAFAT GSDDATCRL FDLRADQEL MTYSHDNII CGITSVSFS 
KSGRLLLAG YDDFNCNVW DALKADRAG VLAGHDNRV SCLGVTDDG 
MAVATGSWD SFLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7Y89_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF RE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ13304
Sequence
>7Y89_Chain_R
GQETPLENM LFASFYLLD FILALVGNT LALWLFIRD HKSGTPANV 
FLMHLAVAD LSCVLVLPT RLVYHFSGN HWPFGEIAC RLTGFLFYL 
NMYASIYFL TCISADRFL AIVHPVKSL KLRRPLYAH LACAFLWVV 
VAVAMAPLL VSPQTVQTN HTVVCLQLY REKASHHAL VSLAVAFTF 
PFITTVTCY LLIIRSLRQ GLRVEKRLK TKAVRMIAI VLAIFLVCF 
VPYHVNRSV YVLHYRSHG ASCATQRIL ALANRITSC LTSLNGALD 
PIMYFFVAE KFRHALCNL LCG


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7Y89 (No Gprot) AOrphanOrphanGPR17 (CysLT)Homo sapiens--3.022022-10-1210.1002/mco2.159




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