Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:E54 9.5725175
2R:R:T55 3.82754175
3R:R:Y66 4.6045108
4R:R:F70 3.1775407
5R:R:N77 3.985409
6R:R:L83 3.3825497
7R:R:P93 4.754526
8R:R:F97 5.14167627
9R:R:H100 9.145429
10R:R:D105 7.495429
11R:R:R115 7.9154107
12R:R:H119 6.086105
13R:R:W125 6.578577109
14R:R:N142 6.19408
15R:R:M143 5.76528
16R:R:Y144 6.41627
17R:R:I147 4.71857727
18R:R:F149 5.71333628
19R:R:T151 5.0775427
20R:R:R157 6.786529
21R:R:F158 5.5685208
22R:R:H163 3.8754206
23R:R:R171 4.92714726
24R:R:W184 5.6525429
25R:R:T200 4.74754104
26R:R:C209 7.8454109
27R:R:L212 6.93754103
28R:R:Y213 6.311676105
29R:R:K216 10.5154142
30R:R:T236 5.4975428
31R:R:Y240 6.24333629
32R:R:K258 4.1925406
33R:R:F272 4.75429
34R:R:F276 8.725429
35R:R:Y279 5.18667627
36R:R:Y286 10.92254144
37R:R:V287 4.11254145
38R:R:Y290 6.185143
39R:R:L305 4.24754171
40R:R:N317 6.44409
41R:R:D321 5.238529
42R:R:M324 3.7475427
43R:R:Y325 8.512599
44R:R:F326 4.57857796
45R:R:F332 3.785408
46A:A:V34 6.236545
47A:A:L36 3.8875447
48A:A:K46 4.065219
49A:A:I49 4.19407
50A:A:Q52 5.7875449
51A:A:M53 7.935448
52A:A:L194 5.115444
53A:A:F196 7.872547
54A:A:F199 9.0875415
55A:A:D200 3.33254219
56A:A:R208 3.94519
57A:A:K210 4.916519
58A:A:W211 4.874519
59A:A:H213 6.875418
60A:A:F215 4.91286719
61A:A:D229 5.3775458
62A:A:Y230 5.082558
63A:A:F250 5.145409
64A:A:I253 3.815418
65A:A:N256 4.3575418
66A:A:W258 7.2615
67A:A:F259 4.07333619
68A:A:I265 3.195448
69A:A:L266 3.9675479
70A:A:F267 4.16286749
71A:A:L268 5.8575478
72A:A:F274 10.97459
73A:A:K277 4.9459
74A:A:C286 3.26406
75A:A:Y287 4.79667657
76A:A:Y290 5.056507
77A:A:Y296 6.9575474
78A:A:E298 5.4654224
79A:A:I303 5.1675457
80A:A:F307 4.44408
81A:A:N311 4.685478
82A:A:K317 3.5925477
83A:A:I319 5.325475
84A:A:Y320 7.17547
85A:A:T321 5.025475
86A:A:H322 8.558549
87A:A:K330 6.61444
88A:A:N331 5.88333648
89A:A:F334 6.4475443
90A:A:F336 4.9648
91A:A:L353 5.8975427
92B:B:L14 6.6754158
93B:B:L30 3.324115
94B:B:T34 4.474115
95B:B:V40 4.30754113
96B:B:H54 9.268336129
97B:B:Y59 7.016518
98B:B:W63 5.49167607
99B:B:W82 10.016129
100B:B:D83 7.0275468
101B:B:S84 3.19465
102B:B:Y85 10.275464
103B:B:N88 4.09567
104B:B:K89 6.521437129
105B:B:H91 4.675485
106B:B:I93 5.7575487
107B:B:L95 4.2325488
108B:B:W99 7.21167619
109B:B:Y105 3.944506
110B:B:N110 6.19414
111B:B:Y111 6.15514
112B:B:C114 3.8175488
113B:B:N119 4.3025409
114B:B:I123 3.564516
115B:B:Y124 6.20167686
116B:B:V133 5.7925484
117B:B:H142 6.16333619
118B:B:Y145 5.702518
119B:B:L146 3.55417
120B:B:F151 3.776519
121B:B:L152 4.2325403
122B:B:I157 3.6625417
123B:B:T159 5.34419
124B:B:D163 8.695419
125B:B:T165 5.145417
126B:B:W169 9.01167618
127B:B:Q176 7.1525414
128B:B:F180 6.938537
129B:B:H183 6.26429739
130B:B:D186 4.79519
131B:B:V187 4.2525439
132B:B:F199 6.46439
133B:B:V200 6.0375436
134B:B:S201 4.915439
135B:B:C204 5.8625417
136B:B:D205 5.5125439
137B:B:K209 9.0975436
138B:B:L210 4.1525405
139B:B:W211 7.83571738
140B:B:E215 10.3154243
141B:B:Q220 7.224537
142B:B:F222 6.465438
143B:B:H225 9.33667639
144B:B:D228 7.5425419
145B:B:I232 4.698538
146B:B:F235 7.1725186
147B:B:P236 5.68254187
148B:B:F241 6.4575436
149B:B:T243 5.065438
150B:B:D247 7.486539
151B:B:R251 8.948538
152B:B:F253 6.852536
153B:B:R256 6.1125409
154B:B:D258 10.4425437
155B:B:Y264 4.992867115
156B:B:I269 2.9145134
157B:B:F278 4.7085187
158B:B:R283 8.2045119
159B:B:L286 3.2785197
160B:B:Y289 5.666676137
161B:B:D290 7.375416
162B:B:N295 6.095136
163B:B:V296 3.12405
164B:B:D298 9.11754119
165B:B:L300 5.33754116
166B:B:K301 5.2475405
167B:B:R304 6.325135
168B:B:V307 3.0045133
169B:B:H311 8.1545169
170B:B:R314 10.015418
171B:B:L318 3.585196
172B:B:M325 4.6575405
173B:B:W332 8.88143719
174B:B:D333 6.3254169
175B:B:K337 8.1254166
176B:B:W339 9.2125169
177B:B:N340 6.7525469
178G:G:E22 3.6325439
179G:G:D48 5.52833609
180G:G:P60 6.0575469
181G:G:F61 4.25868
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F276 R:R:N317 10.89989.67YesYes099
2R:R:F276 R:R:M143 35.01483.73YesYes298
3R:R:M143 R:R:Y279 61.16055.99YesYes287
4R:R:Y140 R:R:Y279 16.40262.98NoYes047
5R:R:F139 R:R:Y140 15.06195.16NoNo074
6R:R:F139 R:R:R115 23.872713.9NoYes077
7R:R:L212 R:R:R115 13.24688.5YesYes1037
8R:R:C108 R:R:D105 11.37976.22NoYes069
9R:R:C108 R:R:N142 11.2334.72NoYes068
10R:R:L138 R:R:N142 10.25125.49NoYes058
11R:R:D105 R:R:N77 18.40159.42YesYes099
12R:R:N77 R:R:P322 18.94453.26YesNo099
13R:R:F326 R:R:P322 19.05032.89YesNo969
14R:R:F326 R:R:Y325 20.4754.13YesYes969
15R:R:F332 R:R:Y325 99.57675.16YesYes089
16R:R:D87 R:R:F332 99.93142.39NoYes048
17R:R:D87 R:R:K89 99.96592.77NoNo046
18B:B:F335 R:R:K89 1003.72NoNo046
19R:R:D105 R:R:D321 11.05229.31YesYes299
20R:R:F149 R:R:L101 12.92223.65YesNo289
21R:R:C180 R:R:F149 17.04672.79NoYes288
22R:R:C180 R:R:F97 17.72352.79NoYes287
23R:R:F97 R:R:P93 28.3224.33YesYes276
24R:R:D321 R:R:N317 11.8765.39YesYes099
25R:R:I147 R:R:M143 27.71094.37YesYes278
26R:R:F272 R:R:I147 29.70482.51YesYes297
27R:R:F272 R:R:F276 24.72426.43YesYes299
28R:R:F272 R:R:T236 47.7335.19YesYes298
29R:R:T236 R:R:Y240 48.68862.5YesYes289
30R:R:R157 R:R:Y240 32.02475.14YesYes299
31R:R:F97 R:R:I153 41.9655.02YesNo279
32R:R:P93 R:R:R171 27.81445.76YesYes266
33R:R:D156 R:R:F97 27.91424.78NoYes277
34R:R:D156 R:R:R171 27.72248.34NoYes276
35R:R:L98 R:R:Y325 79.780819.93NoYes089
36R:R:M324 R:R:R157 23.7466.2YesYes279
37R:R:L98 R:R:M324 79.74352.83NoYes087
38R:R:V268 R:R:Y240 20.9033.79NoYes089
39R:R:M324 R:R:V268 21.53963.04YesNo078
40A:A:N347 R:R:R171 53.91153.62NoYes286
41A:A:V339 A:A:V34 26.41898.02NoYes485
42A:A:I343 A:A:V339 60.24013.07NoNo078
43A:A:I343 A:A:N347 60.69174.25NoNo078
44A:A:F196 A:A:V339 33.36935.24YesNo478
45B:B:Q75 B:B:W99 35.55973.29NoYes199
46B:B:Q75 B:B:Y59 35.455312.4NoYes198
47B:B:W332 B:B:Y59 35.43453.86YesYes198
48B:B:N313 B:B:W332 86.14216.78NoYes079
49B:B:D333 B:B:N313 86.1154.04YesNo097
50B:B:D333 B:B:F335 97.44347.17YesNo094
51R:R:E215 R:R:N307 24.08533.94NoNo034
52R:R:N307 R:R:R283 12.84564.82NoNo045
53R:R:R283 R:R:Y279 29.698110.29NoYes057
54R:R:N307 R:R:T310 12.84812.92NoNo047
55R:R:T310 R:R:Y279 15.25133.75NoYes077
56R:R:K216 R:R:R283 16.05779.9YesNo025
57R:R:K216 R:R:R291 12.043813.61YesNo1421
58R:R:R291 R:R:Y286 11.246114.4NoYes1414
59R:R:E215 R:R:Y286 22.481314.59NoYes034
60R:R:Y286 R:R:Y290 26.49972.98YesYes1443
61R:R:T299 R:R:Y290 14.45812.5NoYes013
62B:B:M61 B:B:W63 10.00733.49NoYes067
63B:B:C317 B:B:M61 10.16954.86NoNo076
64B:B:C317 B:B:S316 10.49963.44NoNo079
65B:B:S316 B:B:W332 10.66893.71NoYes099
66A:A:L36 A:A:V34 14.38994.47YesYes475
67A:A:F196 A:A:L36 14.3923.65YesYes477
68A:A:I222 A:A:L36 24.13364.28NoYes477
69A:A:F259 A:A:W258 37.11883.01YesYes195
70A:A:W258 B:B:W332 45.953.75YesYes159
71A:A:I221 A:A:I253 11.38162.94NoYes088
72A:A:F259 A:A:I221 11.44146.28YesNo098
73A:A:G40 A:A:K46 11.17346.97NoYes099
74A:A:C224 A:A:G40 12.56961.96NoNo079
75A:A:C224 A:A:I49 13.96564.91NoYes077
76A:A:M53 A:A:Q52 10.2610.88YesYes489
77A:A:F189 A:A:M53 11.13614.93NoYes498
78A:A:F189 A:A:F196 12.996712.86NoYes497
79A:A:F267 A:A:I49 11.17316.28YesYes097
80A:A:F267 A:A:I222 22.27682.51YesNo497
81A:A:F307 A:A:L266 17.17853.65YesYes089
82A:A:F250 A:A:L266 29.66763.65YesYes099
83A:A:F223 A:A:F250 37.569510.72NoYes099
84A:A:F223 A:A:L249 37.90764.87NoNo099
85A:A:L249 A:A:R208 27.07464.86NoYes199
86A:A:I212 A:A:R208 36.31633.76NoYes189
87A:A:I212 A:A:N256 18.20922.83NoYes188
88A:A:N256 A:A:W258 18.23096.78YesYes185
89A:A:F259 A:A:I212 18.26085.02YesNo198
90A:A:I253 A:A:L249 11.16974.28YesNo189
91A:A:L266 A:A:L268 10.47194.15YesYes798
92A:A:F307 A:A:I303 12.26742.51YesYes087
93B:B:L117 B:B:W99 25.71096.83NoYes099
94A:A:R208 A:A:W211 18.67496YesYes199
95A:A:F215 A:A:W211 13.09394.01YesYes199
96A:A:S206 A:A:W211 30.3344.94NoYes189
97B:B:M101 B:B:Y145 25.13534.79NoYes098
98B:B:L117 B:B:M101 25.21932.83NoNo099
99A:A:S206 B:B:D186 26.06022.94NoYes189
100B:B:C204 B:B:D186 26.38173.11YesYes179
101B:B:C204 B:B:D228 25.807312.45YesYes179
102B:B:W297 B:B:Y264 11.38811.58NoYes085
103B:B:W297 B:B:Y289 11.26825.79NoYes087
104B:B:C271 B:B:Y289 13.52664.03NoYes057
105B:B:C271 B:B:D290 14.3077.78NoYes056
106B:B:D290 B:B:R314 14.525215.48YesYes168
107B:B:H311 B:B:T329 10.46326.85YesNo098
108B:B:D333 B:B:H311 13.95893.78YesYes1699
109B:B:H142 B:B:S161 16.806113.95YesNo199
110B:B:G162 B:B:S161 18.2583.71NoNo199
111B:B:G162 B:B:Y145 14.22385.79NoYes198
112B:B:I232 B:B:T243 15.89113.04YesYes388
113B:B:H225 B:B:T243 20.61316.85YesYes398
114B:B:D247 B:B:H225 26.294610.08YesYes399
115B:B:D247 B:B:S227 33.36297.36YesNo096
116B:B:D246 B:B:S227 33.9692.94NoNo096
117B:B:D228 B:B:D246 29.98126.65YesNo099
118R:R:I153 R:R:M324 34.70352.92NoYes297
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7Y89
Class A
SubFamily Orphan
Type A orphans
SubType GPR17 (CysLT)
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.02
Date 2022-10-12
D.O.I. 10.1002/mco2.159
Net Summary
Imin 2.5
Number of Linked Nodes 850
Number of Links 1067
Number of Hubs 181
Number of Links mediated by Hubs 665
Number of Communities 24
Number of Nodes involved in Communities 289
Number of Links involved in Communities 415
Path Summary
Number Of Nodes in MetaPath 119
Number Of Links MetaPath 118
Number of Shortest Paths 1926175
Length Of Smallest Path 3
Average Path Length 27.5178
Length of Longest Path 51
Minimum Path Strength 1.345
Average Path Strength 5.61259
Maximum Path Strength 23.525
Minimum Path Correlation 0.7
Average Path Correlation 0.982854
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.125
Average % Of Corr. Nodes 44.3136
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.7274
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ13304
Sequence
>7Y89_Chain_R
GQETPLENM LFASFYLLD FILALVGNT LALWLFIRD HKSGTPANV 
FLMHLAVAD LSCVLVLPT RLVYHFSGN HWPFGEIAC RLTGFLFYL 
NMYASIYFL TCISADRFL AIVHPVKSL KLRRPLYAH LACAFLWVV 
VAVAMAPLL VSPQTVQTN HTVVCLQLY REKASHHAL VSLAVAFTF 
PFITTVTCY LLIIRSLRQ GLRVEKRLK TKAVRMIAI VLAIFLVCF 
VPYHVNRSV YVLHYRSHG ASCATQRIL ALANRITSC LTSLNGALD 
PIMYFFVAE KFRHALCNL LCG


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7Y89_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKST 
IVKQMTGIV ETHFTFKDL HFKMFDVGA QRSERKKWI HCFEGVTAI 
IFCVALSDY DLVNRMHES MKLFDSICN NKWFTDTSI ILFLNKKDL 
FEEKIKKSP LTICYPEYA GSNTYEEAA AYIQCQFED LNKRKDTKE 
IYTHFTCST DTKNVQFVF DAVTDVIIK NNLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7Y89_Chain_B
EAEQLKNQI RDARKACAD ATLSQITNN IDPVGRIQM RTRRTLRGH 
LAKIYAMHW GTDSRLLVS ASQDGKLII WDSYTTNKV HAIPLRSSW 
VMTCAYAPS GNYVACGGL DNICSIYNL KTREGNVRV SRELAGHTG 
YLSCCRFLD DNQIVTSSG DTTCALWDI ETGQQTTTF TGHTGDVMS 
LSLAPDTRL FVSGACDAS AKLWDVREG MCRQTFTGH ESDINAICF 
FPNGNAFAT GSDDATCRL FDLRADQEL MTYSHDNII CGITSVSFS 
KSGRLLLAG YDDFNCNVW DALKADRAG VLAGHDNRV SCLGVTDDG 
MAVATGSWD SFLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7Y89_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF RE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7Y89.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.