psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E54	R:R:N123	5.26	No	No	0	5	5
2	R:R:P56	R:R:T55	5.25	No	No	0	3	5
3	R:R:L57	R:R:P56	3.28	No	No	0	4	3
4	R:R:E58	R:R:L305	5.3	No	No	0	3	1
5	R:R:H119	R:R:N59	10.2	Yes	No	0	5	6
6	R:R:F120	R:R:M60	4.98	No	No	0	4	5
7	R:R:F62	R:R:H119	11.31	No	Yes	1	5	5
8	R:R:F62	R:R:R308	25.66	No	Yes	1	5	3
9	R:R:D69	R:R:F65	4.78	Yes	No	0	7	5
10	R:R:C312	R:R:F65	5.59	No	No	0	5	5
11	R:R:L112	R:R:Y66	4.69	No	Yes	0	8	8
12	R:R:R115	R:R:Y66	12.35	Yes	Yes	1	7	8
13	R:R:H119	R:R:Y66	4.36	Yes	Yes	1	5	8
14	R:R:Y213	R:R:Y66	4.96	Yes	Yes	1	5	8
15	R:R:R308	R:R:Y66	10.29	Yes	Yes	1	3	8
16	R:R:I71	R:R:L67	4.28	No	No	0	5	4
17	R:R:D69	R:R:L112	4.07	Yes	No	0	7	8
18	R:R:D69	R:R:L316	4.07	Yes	No	0	7	5
19	R:R:A319	R:R:D69	4.63	No	Yes	0	8	7
20	R:R:F70	R:R:L74	3.65	No	No	0	7	5
21	R:R:F70	R:R:P113	4.33	No	No	0	7	8
22	R:R:L74	R:R:V109	2.98	No	No	0	5	6
23	R:R:G76	R:R:V75	3.68	No	No	0	7	5
24	R:R:G76	R:R:P322	4.06	No	No	0	7	9
25	R:R:D105	R:R:N77	12.12	No	No	0	9	9
26	R:R:N77	R:R:P322	9.77	No	No	0	9	9
27	R:R:F327	R:R:L79	6.09	Yes	No	0	7	6
28	R:R:A80	R:R:F326	8.32	No	Yes	0	9	6
29	R:R:A102	R:R:L81	3.15	No	No	0	8	7
30	R:R:L81	R:R:V103	2.98	No	No	0	7	6
31	R:R:R86	R:R:W82	10	Yes	No	5	4	4
32	R:R:L339	R:R:W82	10.25	No	No	5	5	4
33	R:R:F332	R:R:L83	10.96	No	No	0	8	7
34	R:R:F84	R:R:N95	6.04	No	No	0	6	7
35	R:R:F84	R:R:M99	19.9	No	No	0	6	6
36	R:R:L339	R:R:R86	3.64	No	Yes	5	5	4
37	R:R:N95	R:R:S90	2.98	No	No	0	7	6
38	R:R:P93	R:R:T92	5.25	Yes	No	4	6	7
39	R:R:R171	R:R:T92	3.88	Yes	No	4	6	7
40	R:R:D156	R:R:P93	3.22	No	Yes	4	7	6
41	R:R:P93	R:R:R171	10.09	Yes	Yes	4	6	6
42	R:R:A176	R:R:V96	5.09	No	No	0	7	7
43	R:R:H177	R:R:V96	16.61	No	No	0	3	7
44	R:R:C152	R:R:F97	6.98	No	No	0	7	7
45	R:R:F97	R:R:I153	3.77	No	No	0	7	9
46	R:R:L98	R:R:Y325	3.52	No	Yes	0	8	9
47	R:R:F326	R:R:L98	10.96	Yes	No	0	6	8
48	R:R:H100	R:R:M99	6.57	Yes	No	0	9	6
49	R:R:F149	R:R:H100	3.39	Yes	Yes	3	8	9
50	R:R:C180	R:R:H100	14.74	No	Yes	3	8	9
51	R:R:H100	R:R:W184	6.35	Yes	Yes	3	9	9
52	R:R:L101	R:R:S146	3	No	No	0	9	9
53	R:R:D321	R:R:L101	10.86	Yes	No	0	9	9
54	R:R:D105	R:R:G318	5.03	No	No	0	9	8
55	R:R:D105	R:R:D321	5.32	No	Yes	0	9	9
56	R:R:L106	R:R:V109	2.98	No	No	0	7	6
57	R:R:N142	R:R:S107	2.98	No	No	0	8	6
58	R:R:C108	R:R:N142	11.02	No	No	0	6	8
59	R:R:T114	R:R:T135	3.14	No	No	0	7	5
60	R:R:F139	R:R:R115	11.76	No	Yes	1	7	7
61	R:R:L212	R:R:R115	14.58	No	Yes	0	3	7
62	R:R:R115	R:R:Y213	5.14	Yes	Yes	1	7	5
63	R:R:R115	R:R:S311	3.95	Yes	Yes	1	7	6
64	R:R:P126	R:R:V117	3.53	No	No	2	3	3
65	R:R:F127	R:R:V117	6.55	Yes	No	2	7	3
66	R:R:H119	R:R:Y118	3.27	Yes	No	0	5	5
67	R:R:N123	R:R:Y118	10.47	No	No	0	5	5
68	R:R:H119	R:R:Y213	8.71	Yes	Yes	1	5	5
69	R:R:H119	R:R:R308	5.64	Yes	Yes	1	5	3
70	R:R:G122	R:R:H124	3.18	No	No	0	3	5
71	R:R:H124	R:R:H205	16.72	No	No	0	5	5
72	R:R:F127	R:R:W125	15.03	Yes	No	2	7	9
73	R:R:C132	R:R:W125	3.92	No	No	2	9	9
74	R:R:C209	R:R:W125	10.45	No	No	2	9	9
75	R:R:F127	R:R:P126	8.67	Yes	No	2	7	3
76	R:R:E129	R:R:R133	17.45	No	No	0	3	7
77	R:R:C132	R:R:Q199	3.05	No	Yes	2	9	4
78	R:R:C132	R:R:C209	7.28	No	No	2	9	9
79	R:R:P198	R:R:R133	5.76	No	No	0	4	7
80	R:R:L134	R:R:L138	4.15	No	No	0	4	5
81	R:R:F137	R:R:L141	3.65	Yes	No	0	6	5
82	R:R:F137	R:R:L194	4.87	Yes	No	0	6	4
83	R:R:F137	R:R:L195	6.09	Yes	No	0	6	5
84	R:R:F139	R:R:Y140	6.19	No	Yes	0	7	4
85	R:R:F139	R:R:S311	3.96	No	Yes	1	7	6
86	R:R:M191	R:R:Y140	7.18	No	Yes	0	6	4
87	R:R:R214	R:R:Y140	20.58	No	Yes	0	3	4
88	R:R:Y140	R:R:Y279	4.96	Yes	Yes	0	4	7
89	R:R:L141	R:R:W184	4.56	No	Yes	0	5	9
90	R:R:L141	R:R:V187	2.98	No	No	0	5	8
91	R:R:M143	R:R:Y144	5.99	Yes	Yes	0	8	7
92	R:R:F276	R:R:M143	4.98	No	Yes	0	9	8
93	R:R:M143	R:R:Y279	5.99	Yes	Yes	1	8	7
94	R:R:M143	R:R:T314	4.52	Yes	No	1	8	8
95	R:R:M191	R:R:Y144	3.59	No	Yes	0	6	7
96	R:R:A228	R:R:Y144	5.34	No	Yes	0	5	7
97	R:R:H280	R:R:Y144	6.53	No	Yes	0	8	7
98	R:R:A145	R:R:F149	4.16	No	Yes	3	7	8
99	R:R:A145	R:R:W184	3.89	No	Yes	3	7	9
100	R:R:I147	R:R:P232	3.39	No	No	0	7	9
101	R:R:F276	R:R:I147	15.07	No	No	0	9	7
102	R:R:P232	R:R:Y148	11.13	No	No	0	9	6
103	R:R:C180	R:R:F149	5.59	No	Yes	3	8	8
104	R:R:F149	R:R:L183	3.65	Yes	No	0	8	7
105	R:R:F149	R:R:W184	10.02	Yes	Yes	3	8	9
106	R:R:F272	R:R:L150	4.87	No	No	0	9	9
107	R:R:L150	R:R:Y325	4.69	No	Yes	0	9	9
108	R:R:P232	R:R:T151	5.25	No	No	0	9	7
109	R:R:T151	R:R:T235	4.71	No	No	0	7	7
110	R:R:T151	R:R:T236	4.71	No	No	0	7	8
111	R:R:I153	R:R:R157	6.26	No	No	6	9	9
112	R:R:I153	R:R:Y325	6.04	No	Yes	6	9	9
113	R:R:S154	R:R:T236	6.4	No	No	0	9	8
114	R:R:C239	R:R:S154	5.16	No	No	0	7	9
115	R:R:S154	R:R:Y240	13.99	No	Yes	0	9	9
116	R:R:D156	R:R:R171	13.1	No	Yes	4	7	6
117	R:R:R157	R:R:Y240	8.23	No	Yes	0	9	9
118	R:R:R157	R:R:Y325	5.14	No	Yes	6	9	9
119	R:R:F158	R:R:V162	9.18	Yes	No	7	8	7
120	R:R:F158	R:R:H163	4.53	Yes	Yes	7	8	6
121	R:R:C239	R:R:F158	5.59	No	Yes	0	7	8
122	R:R:F158	R:R:L242	7.31	Yes	No	0	8	4
123	R:R:F158	R:R:I243	3.77	Yes	No	0	8	8
124	R:R:A160	R:R:R171	6.91	No	Yes	0	8	6
125	R:R:H163	R:R:V162	4.15	Yes	No	7	6	7
126	R:R:S246	R:R:V162	3.23	No	No	0	5	7
127	R:R:R171	R:R:S167	5.27	Yes	No	0	6	5
128	R:R:R172	R:R:Y175	4.12	No	No	0	6	3
129	R:R:F182	R:R:V186	7.87	No	No	0	4	4
130	R:R:L194	R:R:Q211	7.99	No	Yes	0	4	4
131	R:R:Q199	R:R:S197	5.78	Yes	No	2	4	4
132	R:R:Q211	R:R:S197	4.33	Yes	No	2	4	4
133	R:R:L210	R:R:Q199	3.99	No	Yes	0	3	4
134	R:R:Q199	R:R:Q211	16.64	Yes	Yes	2	4	4
135	R:R:T200	R:R:V207	3.17	No	No	0	4	5
136	R:R:V201	R:R:V208	9.62	No	No	0	1	4
137	R:R:L210	R:R:V201	4.47	No	No	0	3	1
138	R:R:Q202	R:R:V207	11.46	No	No	0	1	5
139	R:R:N204	R:R:T203	10.24	No	No	0	3	2
140	R:R:T203	R:R:T206	7.85	No	No	0	2	3
141	R:R:H205	R:R:T206	10.95	No	No	0	5	3
142	R:R:T206	R:R:V208	4.76	No	No	0	3	4
143	R:R:C209	R:R:L212	3.17	No	No	0	9	3
144	R:R:Q211	R:R:R214	10.51	Yes	No	0	4	3
145	R:R:R308	R:R:Y213	21.61	Yes	Yes	1	3	5
146	R:R:S311	R:R:Y213	5.09	Yes	Yes	1	6	5
147	R:R:R214	R:R:R283	13.86	No	No	0	3	5
148	R:R:E215	R:R:Y286	10.1	No	Yes	8	3	4
149	R:R:E215	R:R:Y290	6.73	No	Yes	8	3	3
150	R:R:K216	R:R:S218	6.12	No	No	0	2	3
151	R:R:A217	R:R:H219	4.39	No	No	0	1	2
152	R:R:A217	R:R:R291	5.53	No	No	0	1	1
153	R:R:H220	R:R:S218	8.37	No	No	0	5	3
154	R:R:A221	R:R:S218	3.42	No	No	0	5	3
155	R:R:L222	R:R:V287	11.92	No	No	0	5	5
156	R:R:H280	R:R:L225	3.86	No	No	0	8	6
157	R:R:F229	R:R:F233	4.29	No	No	9	8	6
158	R:R:F229	R:R:H280	28.28	No	No	0	8	8
159	R:R:F231	R:R:T235	3.89	No	No	0	5	7
160	R:R:F233	R:R:V237	3.93	No	No	0	6	4
161	R:R:F272	R:R:T236	10.38	No	No	0	9	8
162	R:R:L241	R:R:V237	2.98	No	No	0	3	4
163	R:R:I265	R:R:Y240	3.63	No	Yes	0	7	9
164	R:R:L269	R:R:Y240	5.86	No	Yes	0	8	9
165	R:R:I244	R:R:V262	6.14	No	No	0	5	6
166	R:R:I244	R:R:I265	5.89	No	No	0	5	7
167	R:R:L251	R:R:V253	5.96	No	No	0	4	2
168	R:R:K258	R:R:V253	4.55	Yes	No	0	6	2
169	R:R:E254	R:R:L257	7.95	No	No	0	4	5
170	R:R:K255	R:R:T259	3	No	No	0	4	5
171	R:R:L257	R:R:R256	6.07	No	No	0	5	4
172	R:R:M264	R:R:V328	3.04	No	No	0	8	5
173	R:R:M324	R:R:V268	3.04	No	No	0	7	8
174	R:R:V268	R:R:Y325	5.05	No	Yes	0	8	9
175	R:R:L273	R:R:V277	4.47	No	Yes	0	6	5
176	R:R:C275	R:R:L316	4.76	No	No	0	9	5
177	R:R:C275	R:R:N317	12.6	No	No	0	9	9
178	R:R:F276	R:R:N317	8.46	No	No	0	9	9
179	R:R:P278	R:R:V277	3.53	No	Yes	0	9	5
180	R:R:R283	R:R:Y279	13.38	No	Yes	0	5	7
181	R:R:T310	R:R:Y279	3.75	No	Yes	0	7	7
182	R:R:T314	R:R:Y279	3.75	No	Yes	1	8	7
183	R:R:A306	R:R:N282	3.13	No	No	0	5	5
184	R:R:N282	R:R:T310	7.31	No	No	0	5	7
185	R:R:N307	R:R:R283	12.05	No	No	0	4	5
186	R:R:V287	R:R:Y286	3.79	No	Yes	0	5	4
187	R:R:Y286	R:R:Y290	25.81	Yes	Yes	8	4	3
188	R:R:L303	R:R:Y286	9.38	No	Yes	0	4	4
189	R:R:R291	R:R:Y290	13.38	No	Yes	0	1	3
190	R:R:S296	R:R:T299	6.4	No	No	0	5	1
191	R:R:C297	R:R:Q300	3.05	No	No	0	7	2
192	R:R:I302	R:R:R301	7.52	No	No	0	3	3
193	R:R:I309	R:R:L305	4.28	No	No	0	5	1
194	R:R:N307	R:R:T310	4.39	No	No	0	4	7
195	R:R:C312	R:R:R308	9.75	No	Yes	0	5	3
196	R:R:S311	R:R:T314	3.2	Yes	No	1	6	8
197	R:R:C312	R:R:S315	3.44	No	No	0	5	7
198	R:R:L316	R:R:L320	8.3	No	No	0	5	6
199	R:R:D321	R:R:P322	3.22	Yes	No	0	9	9
200	R:R:D321	R:R:Y325	5.75	Yes	Yes	0	9	9
201	R:R:F327	R:R:I323	3.77	Yes	No	0	7	7
202	R:R:F326	R:R:F327	3.22	Yes	Yes	0	6	7
203	R:R:F326	R:R:F332	6.43	Yes	No	0	6	8
204	R:R:F327	R:R:L336	6.09	Yes	No	0	7	5
205	R:R:E330	R:R:R333	15.12	No	No	0	4	8
206	R:R:L242	R:R:T238	2.95	No	No	0	4	4
207	R:R:L303	R:R:T299	2.95	No	No	0	4	1
208	R:R:I267	R:R:M324	2.92	No	No	0	5	7
209	R:R:I71	R:R:L72	2.85	No	No	0	5	5
210	R:R:E58	R:R:T55	2.82	No	No	0	3	5
211	R:R:E129	R:R:T200	2.82	No	No	0	3	4
212	R:R:L116	R:R:L67	2.77	No	No	0	7	4
213	R:R:L68	R:R:L72	2.77	No	No	0	5	5
214	R:R:L106	R:R:L81	2.77	No	No	0	7	7
215	R:R:A335	R:R:R86	2.77	No	Yes	0	5	4
216	R:R:H100	R:R:V96	2.77	Yes	No	0	9	7
217	R:R:A176	R:R:F97	2.77	No	No	0	7	7
218	R:R:A102	R:R:F326	2.77	No	Yes	0	8	6
219	R:R:H289	R:R:T299	2.74	No	No	0	3	1
220	R:R:E129	R:R:I130	2.73	No	No	0	3	3
221	R:R:K216	R:R:Q211	2.71	No	Yes	0	2	4
222	R:R:E330	R:R:K260	2.7	No	No	0	4	7
223	R:R:R115	R:R:V111	2.62	Yes	No	0	7	6
224	R:R:F229	R:R:V277	2.62	No	Yes	9	8	5
225	R:R:F233	R:R:V277	2.62	No	Yes	9	6	5
226	R:R:A104	R:R:W184	2.59	No	Yes	0	8	9
227	R:R:R256	R:R:T259	2.59	No	No	0	4	5
228	R:R:F84	R:R:I85	2.51	No	No	0	6	4
229	R:R:I244	R:R:R248	2.51	No	No	0	5	4
230	R:R:F332	R:R:K331	2.48	No	No	0	8	6
231	R:R:F137	R:R:L138	2.44	Yes	No	0	6	5
232	R:R:N282	R:R:Y286	2.33	No	Yes	0	5	4
233	R:R:Q300	R:R:Y290	2.25	No	Yes	0	2	3
234	R:R:A176	R:R:P93	1.87	No	Yes	0	7	6
235	R:R:A192	R:R:P193	1.87	No	No	0	4	7
236	R:R:G136	R:R:T135	1.82	No	No	0	5	5
237	R:R:A155	R:R:C239	1.81	No	No	0	6	7
238	R:R:A319	R:R:A73	1.79	No	No	0	8	8
239	R:R:P126	R:R:S121	1.78	No	No	0	3	4
240	R:R:P198	R:R:S197	1.78	No	No	0	4	4
241	R:R:G250	R:R:K258	1.74	No	Yes	0	6	6
242	R:R:A104	R:R:S107	1.71	No	No	0	8	6
243	R:R:G136	R:R:L194	1.71	No	No	0	5	4
244	R:R:A298	R:R:S296	1.71	No	No	0	2	5
245	R:R:A94	R:R:T92	1.68	No	No	0	7	7
246	R:R:L313	R:R:P278	1.64	No	No	0	8	9
247	R:R:A160	R:R:I161	1.62	No	No	0	8	8
248	R:R:S224	R:R:V223	1.62	No	No	0	5	3
249	R:R:V185	R:R:V189	1.6	No	No	0	4	3
250	R:R:V277	R:R:V281	1.6	Yes	No	0	5	6
251	R:R:A63	R:R:L116	1.58	No	No	0	5	7
252	R:R:A319	R:R:L72	1.58	No	No	0	8	5
253	R:R:A335	R:R:L83	1.58	No	No	0	5	7
254	R:R:A261	R:R:L247	1.58	No	No	0	7	8
255	R:R:I323	R:R:V328	1.54	No	No	0	7	5
256	R:R:H163	R:R:P164	1.53	Yes	No	0	6	8
257	R:R:I234	R:R:T238	1.52	No	No	0	3	4
258	R:R:F127	R:R:G128	1.51	Yes	No	0	7	8
259	R:R:L61	R:R:S64	1.5	No	No	0	6	5
260	R:R:L159	R:R:S167	1.5	No	No	0	5	5
261	R:R:L288	R:R:S284	1.5	No	No	0	4	5
262	R:R:L247	R:R:V262	1.49	No	No	0	8	6
263	R:R:L74	R:R:T78	1.47	No	No	0	5	3
264	R:R:L106	R:R:T78	1.47	No	No	0	7	3
265	R:R:I271	R:R:M324	1.46	No	No	0	6	7
266	R:R:P173	R:R:R172	1.44	No	No	0	1	6
267	R:R:K255	R:R:K258	1.44	No	Yes	0	4	6
268	R:R:K169	R:R:L170	1.41	No	No	0	4	4
269	R:R:K258	R:R:L247	1.41	Yes	No	0	6	8
270	R:R:A131	R:R:F127	1.39	No	Yes	0	6	7
271	R:R:L174	R:R:L178	1.38	No	No	0	4	3
272	R:R:H220	R:R:V223	1.38	No	No	0	5	3
273	R:R:A298	R:R:R301	1.38	No	No	0	2	3
274	R:R:D87	R:R:N95	1.35	No	No	0	4	7
275	R:R:H163	R:R:K166	1.31	Yes	No	0	6	4
276	R:R:H289	R:R:L288	1.29	No	No	0	3	4
277	R:R:I267	R:R:R263	1.25	No	No	0	5	5
278	R:R:K260	R:R:R256	1.24	No	No	0	7	4
279	R:R:F62	R:R:L305	1.22	No	No	0	5	1
280	R:R:F182	R:R:L183	1.22	No	No	0	4	7
281	R:R:N338	R:R:R86	1.21	No	Yes	0	4	4
282	R:R:L178	R:R:Y175	1.17	No	No	0	3	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y66	7.33	5	1	8
2	R:R:D69	4.3875	4	0	7
3	R:R:R86	4.405	4	5	4
4	R:R:P93	5.1075	4	4	6
5	R:R:H100	6.764	5	3	9
6	R:R:R115	8.4	6	1	7
7	R:R:H119	7.24833	6	1	5
8	R:R:F127	6.63	5	2	7
9	R:R:F137	4.2625	4	0	6
10	R:R:Y140	9.7275	4	0	4
11	R:R:M143	5.37	4	1	8
12	R:R:Y144	5.3625	4	0	7
13	R:R:F149	5.362	5	3	8
14	R:R:F158	6.076	5	7	8
15	R:R:H163	2.88	4	7	6
16	R:R:R171	7.85	5	4	6
17	R:R:W184	5.482	5	3	9
18	R:R:Q199	7.365	4	2	4
19	R:R:Q211	8.436	5	2	4
20	R:R:Y213	9.102	5	1	5
21	R:R:Y240	7.9275	4	0	9
22	R:R:K258	2.285	4	0	6
23	R:R:V277	2.968	5	9	5
24	R:R:Y279	6.366	5	1	7
25	R:R:Y286	10.282	5	8	4
26	R:R:Y290	12.0425	4	8	3
27	R:R:R308	14.59	5	1	3
28	R:R:S311	4.05	4	1	6
29	R:R:D321	6.2875	4	0	9
30	R:R:Y325	5.03167	6	6	9
31	R:R:F326	6.34	5	0	6
32	R:R:F327	4.7925	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F62	R:R:H119	18.7685	11.31	No	Yes	1	5	5
2	R:R:F62	R:R:L305	32.9309	1.22	No	No	0	5	1
3	R:R:E58	R:R:L305	22.235	5.3	No	No	0	3	1
4	R:R:E58	R:R:T55	16.7049	2.82	No	No	0	3	5
5	R:R:P56	R:R:T55	11.1478	5.25	No	No	0	3	5
6	R:R:D69	R:R:L112	15.0189	4.07	Yes	No	0	7	8
7	R:R:L112	R:R:Y66	15.8956	4.69	No	Yes	0	8	8
8	R:R:R115	R:R:Y66	27.6302	12.35	Yes	Yes	1	7	8
9	R:R:H119	R:R:Y213	23.1859	8.71	Yes	Yes	1	5	5
10	R:R:R115	R:R:Y213	14.648	5.14	Yes	Yes	1	7	5
11	R:R:A319	R:R:D69	19.8476	4.63	No	Yes	0	8	7
12	R:R:A319	R:R:L72	14.9649	1.58	No	No	0	8	5
13	R:R:I71	R:R:L72	10.0283	2.85	No	No	0	5	5
14	R:R:D69	R:R:L316	14.5266	4.07	Yes	No	0	7	5
15	R:R:S311	R:R:Y213	33.7402	5.09	Yes	Yes	1	6	5
16	R:R:S311	R:R:T314	35.6825	3.2	Yes	No	1	6	8
17	R:R:M143	R:R:T314	26.2948	4.52	Yes	No	1	8	8
18	R:R:F276	R:R:M143	74.764	4.98	No	Yes	0	9	8
19	R:R:F276	R:R:I147	80.2266	15.07	No	No	0	9	7
20	R:R:I147	R:R:P232	79.6871	3.39	No	No	0	7	9
21	R:R:P232	R:R:T151	79.215	5.25	No	No	0	9	7
22	R:R:T151	R:R:T236	78.7294	4.71	No	No	0	7	8
23	R:R:F272	R:R:T236	37.3078	10.38	No	No	0	9	8
24	R:R:F272	R:R:L150	36.5525	4.87	No	No	0	9	9
25	R:R:L150	R:R:Y325	36.2422	4.69	No	Yes	0	9	9
26	R:R:L98	R:R:Y325	44.6857	3.52	No	Yes	0	8	9
27	R:R:F326	R:R:L98	43.2627	10.96	Yes	No	0	6	8
28	R:R:A102	R:R:F326	20.1915	2.77	No	Yes	0	8	6
29	R:R:A102	R:R:L81	18.6134	3.15	No	No	0	8	7
30	R:R:L106	R:R:L81	15.3493	2.77	No	No	0	7	7
31	R:R:D321	R:R:Y325	16.9881	5.75	Yes	Yes	0	9	9
32	R:R:F326	R:R:F332	13.2722	6.43	Yes	No	0	6	8
33	R:R:F332	R:R:L83	10.1295	10.96	No	No	0	8	7
34	R:R:F139	R:R:R115	30.6987	11.76	No	Yes	1	7	7
35	R:R:F139	R:R:Y140	41.806	6.19	No	Yes	0	7	4
36	R:R:R214	R:R:Y140	65.8417	20.58	No	Yes	0	3	4
37	R:R:Q211	R:R:R214	100	10.51	Yes	No	0	4	3
38	R:R:L194	R:R:Q211	79.6803	7.99	No	Yes	0	4	4
39	R:R:F137	R:R:L194	75.9711	4.87	Yes	No	0	6	4
40	R:R:F137	R:R:L141	72.6531	3.65	Yes	No	0	6	5
41	R:R:L141	R:R:W184	71.021	4.56	No	Yes	0	5	9
42	R:R:H100	R:R:W184	58.0388	6.35	Yes	Yes	3	9	9
43	R:R:H100	R:R:M99	14.5198	6.57	Yes	No	0	9	6
44	R:R:F84	R:R:M99	12.1325	19.9	No	No	0	6	6
45	R:R:F139	R:R:S311	10.932	3.96	No	Yes	1	7	6
46	R:R:H100	R:R:V96	54.5657	2.77	Yes	No	0	9	7
47	R:R:A176	R:R:V96	52.7448	5.09	No	No	0	7	7
48	R:R:A176	R:R:P93	22.2484	1.87	No	Yes	0	7	6
49	R:R:P93	R:R:R171	12.3887	10.09	Yes	Yes	4	6	6
50	R:R:F97	R:R:I153	45.9064	3.77	No	No	0	7	9
51	R:R:I153	R:R:R157	18.1953	6.26	No	No	6	9	9
52	R:R:R157	R:R:Y240	28.5676	8.23	No	Yes	0	9	9
53	R:R:S154	R:R:Y240	36.5929	13.99	No	Yes	0	9	9
54	R:R:S154	R:R:T236	41.9274	6.4	No	No	0	9	8
55	R:R:I153	R:R:Y325	28.9587	6.04	No	Yes	6	9	9
56	R:R:A176	R:R:F97	45.4613	2.77	No	No	0	7	7
57	R:R:L212	R:R:R115	20.259	14.58	No	Yes	0	3	7
58	R:R:C209	R:R:L212	19.335	3.17	No	No	0	9	3
59	R:R:F127	R:R:W125	15.8147	15.03	Yes	No	2	7	9
60	R:R:C132	R:R:Q199	20.5624	3.05	No	Yes	2	9	4
61	R:R:L210	R:R:Q199	23.2398	3.99	No	Yes	0	3	4
62	R:R:L210	R:R:V201	20.7108	4.47	No	No	0	3	1
63	R:R:V201	R:R:V208	18.1683	9.62	No	No	0	1	4
64	R:R:T206	R:R:V208	15.6124	4.76	No	No	0	3	4
65	R:R:E129	R:R:R133	16.0777	17.45	No	No	0	3	7
66	R:R:P198	R:R:R133	19.2541	5.76	No	No	0	4	7
67	R:R:P198	R:R:S197	22.417	1.78	No	No	0	4	4
68	R:R:Q211	R:R:S197	21.0885	4.33	Yes	No	2	4	4
69	R:R:T314	R:R:Y279	10.8376	3.75	No	Yes	1	8	7
70	R:R:M143	R:R:Y144	16.1114	5.99	Yes	Yes	0	8	7
71	R:R:H280	R:R:Y144	19.969	6.53	No	Yes	0	8	7
72	R:R:C239	R:R:S154	22.7003	5.16	No	No	0	7	9
73	R:R:C239	R:R:F158	19.0181	5.59	No	Yes	0	7	8
74	R:R:R283	R:R:Y279	26.1128	13.38	No	Yes	0	5	7
75	R:R:T310	R:R:Y279	54.1745	3.75	No	Yes	0	7	7
76	R:R:N282	R:R:T310	61.7211	7.31	No	No	0	5	7
77	R:R:N282	R:R:Y286	56.1977	2.33	No	Yes	0	5	4
78	R:R:Y286	R:R:Y290	18.1886	25.81	Yes	Yes	8	4	3
79	R:R:K216	R:R:Q211	16.4149	2.71	No	Yes	0	2	4
80	R:R:K216	R:R:S218	13.9533	6.12	No	No	0	2	3
81	R:R:F229	R:R:H280	16.5026	28.28	No	No	0	8	8
82	R:R:I265	R:R:Y240	35.6353	3.63	No	Yes	0	7	9
83	R:R:I244	R:R:I265	33.7605	5.89	No	No	0	5	7
84	R:R:I244	R:R:V262	29.9703	6.14	No	No	0	5	6
85	R:R:L247	R:R:V262	28.0415	1.49	No	No	0	8	6
86	R:R:K258	R:R:L247	24.157	1.41	Yes	No	0	6	8
87	R:R:R256	R:R:T259	12.2336	2.59	No	No	0	4	5
88	R:R:K255	R:R:T259	14.2568	3	No	No	0	4	5
89	R:R:K255	R:R:K258	16.2665	1.44	No	Yes	0	4	6
90	R:R:C275	R:R:L316	16.334	4.76	No	No	0	9	5
91	R:R:C275	R:R:N317	17.8311	12.6	No	No	0	9	9
92	R:R:F276	R:R:N317	19.6453	8.46	No	No	0	9	9
93	R:R:N307	R:R:R283	13.4003	12.05	No	No	0	4	5
94	R:R:N307	R:R:T310	12.8945	4.39	No	No	0	4	7
95	R:R:L303	R:R:Y286	27.2592	9.38	No	Yes	0	4	4
96	R:R:L303	R:R:T299	24.5347	2.95	No	No	0	4	1
97	R:R:S296	R:R:T299	12.3752	6.4	No	No	0	5	1
98	R:R:F62	R:R:R308	19.5239	25.66	No	Yes	1	5	3
99	R:R:R308	R:R:Y213	20.6501	21.61	Yes	Yes	1	3	5
100	R:R:R115	R:R:S311	10.6016	3.95	Yes	Yes	1	7	6
101	R:R:Y140	R:R:Y279	28.8238	4.96	Yes	Yes	0	4	7
102	R:R:M143	R:R:Y279	44.7262	5.99	Yes	Yes	1	8	7
103	R:R:R214	R:R:R283	36.0264	13.86	No	No	0	3	5
104	R:R:Q199	R:R:Q211	31.8654	16.64	Yes	Yes	2	4	4
105	R:R:R157	R:R:Y325	10.2441	5.14	No	Yes	6	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7Y89_nogp

PDB Summary
PDB	7Y89_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	257
Number of Links	282
Number of Hubs	32
Number of Links mediated by Hubs	126
Number of Communities	9
Number of Nodes involved in Communities	44
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	106
Number Of Links MetaPath	105
Number of Shortest Paths	44401
Length Of Smallest Path	3
Average Path Length	13.8982
Length of Longest Path	31
Minimum Path Strength	1.275
Average Path Strength	6.71558
Maximum Path Strength	19.595
Minimum Path Correlation	0.7
Average Path Correlation	0.926702
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	44.0821
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.7092
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • G protein-coupled chemoattractant receptor activity • molecular transducer activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cytokine receptor activity • immune receptor activity • receptor serine/threonine kinase binding • signaling receptor binding • cellular developmental process • nervous system development • neurogenesis • central nervous system development • gliogenesis • oligodendrocyte differentiation • glial cell differentiation • cell differentiation • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • response to stress • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q13304
Sequence	>7Y89_nogp_Chain_R G Q E T P L E N M L F A S F Y L L D F I L A L V G N T L A L W L F I R D H K S G T P A N V F L M H L A V A D L S C V L V L P T R L V Y H F S G N H W P F G E I A C R L T G F L F Y L N M Y A S I Y F L T C I S A D R F L A I V H P V K S L K L R R P L Y A H L A C A F L W V V V A V A M A P L L V S P Q T V Q T N H T V V C L Q L Y R E K A S H H A L V S L A V A F T F P F I T T V T C Y L L I I R S L R Q G L R V E K R L K T K A V R M I A I V L A I F L V C F V P Y H V N R S V Y V L H Y R S H G A S C A T Q R I L A L A N R I T S C L T S L N G A L D P I M Y F F V A E K F R H A L C N L L C G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7Y89	A	Orphan	Orphan	GPR17 (CysLT)	Homo sapiens	-	-	Gi1/β1/γ2	3.02	2022-10-12	doi.org/10.1002/mco2.159
	7Y89 (No Gprot)	A	Orphan	Orphan	GPR17 (CysLT)	Homo sapiens	-	-		3.02	2022-10-12	doi.org/10.1002/mco2.159

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