psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T15	R:R:Y19	4.99	No	Yes	0	4	5
2	R:R:D16	R:R:F17	14.33	No	No	0	4	4
3	R:R:F17	R:R:R268	6.41	No	No	0	4	2
4	R:R:R18	R:R:Y22	4.12	Yes	Yes	1	4	6
5	R:R:R18	R:R:V170	2.62	Yes	Yes	1	4	5
6	R:R:L271	R:R:R18	4.86	No	Yes	0	3	4
7	R:R:R18	R:R:S275	2.64	Yes	No	1	4	4
8	R:R:Y19	R:R:Y78	3.97	Yes	Yes	1	5	5
9	R:R:Y19	R:R:Y79	8.94	Yes	Yes	1	5	5
10	R:R:H82	R:R:Y19	4.36	No	Yes	0	4	5
11	R:R:V170	R:R:Y19	3.79	Yes	Yes	1	5	5
12	R:R:D171	R:R:Y19	4.6	No	Yes	1	4	5
13	R:R:F20	R:R:V24	5.24	No	No	0	4	5
14	R:R:I21	R:R:S275	4.64	No	No	0	5	4
15	R:R:Y22	R:R:Y26	3.97	Yes	Yes	1	6	8
16	R:R:Y22	R:R:Y79	9.93	Yes	Yes	1	6	5
17	R:R:S275	R:R:Y22	7.63	No	Yes	1	4	6
18	R:R:C279	R:R:Y22	2.69	No	Yes	0	5	6
19	L:L:?1	R:R:Y22	3.61	Yes	Yes	1	0	6
20	R:R:I29	R:R:T25	3.04	No	No	0	7	4
21	R:R:C279	R:R:T25	10.14	No	No	0	5	4
22	R:R:L72	R:R:Y26	7.03	No	Yes	0	8	8
23	R:R:R75	R:R:Y26	4.12	Yes	Yes	1	6	8
24	R:R:K98	R:R:Y26	3.58	Yes	Yes	1	6	8
25	L:L:?1	R:R:Y26	2.71	Yes	Yes	1	0	8
26	R:R:I76	R:R:T27	4.56	No	No	0	7	5
27	R:R:I29	R:R:L283	2.85	No	No	0	7	5
28	R:R:C286	R:R:I29	3.27	No	No	0	7	7
29	R:R:L30	R:R:V31	4.47	No	No	0	6	5
30	R:R:P32	R:R:V31	3.53	No	No	0	5	5
31	R:R:I35	R:R:V31	3.07	No	No	0	4	5
32	R:R:I38	R:R:L34	2.85	No	No	0	3	6
33	R:R:G36	R:R:I35	3.53	No	No	0	8	4
34	R:R:D65	R:R:N37	6.73	Yes	Yes	0	9	9
35	R:R:L66	R:R:N37	2.75	No	Yes	0	7	9
36	R:R:N37	R:R:P289	3.26	Yes	No	0	9	9
37	R:R:F294	R:R:L39	3.65	Yes	No	0	7	6
38	R:R:L303	R:R:L39	2.77	No	No	0	6	6
39	R:R:A40	R:R:Y293	5.34	No	Yes	0	9	7
40	R:R:A62	R:R:L41	4.73	No	No	0	8	6
41	R:R:F299	R:R:V43	10.49	Yes	No	0	8	7
42	R:R:F44	R:R:V55	2.62	Yes	Yes	0	6	7
43	R:R:F44	R:R:M58	4.98	Yes	No	0	6	8
44	R:R:F44	R:R:Y293	3.09	Yes	Yes	4	6	7
45	R:R:F299	R:R:F44	5.36	Yes	Yes	4	8	6
46	R:R:K49	R:R:Y45	5.97	No	No	0	6	3
47	R:R:G46	R:R:K49	3.49	No	No	0	4	6
48	R:R:T51	R:R:Y47	8.74	No	Yes	3	6	5
49	R:R:R53	R:R:Y47	4.12	No	Yes	3	6	5
50	R:R:V55	R:R:Y47	2.52	Yes	Yes	0	7	5
51	R:R:E298	R:R:Y47	6.73	No	Yes	3	6	5
52	R:R:R302	R:R:Y47	8.23	No	Yes	3	5	5
53	R:R:E50	R:R:R302	5.82	No	No	0	6	5
54	R:R:R53	R:R:T51	5.17	No	No	3	6	6
55	R:R:D128	R:R:R53	5.96	No	No	0	5	6
56	R:R:I59	R:R:V55	4.61	No	Yes	0	5	7
57	R:R:F57	R:R:I56	7.54	Yes	Yes	2	7	6
58	R:R:D134	R:R:I56	2.8	Yes	Yes	2	8	6
59	R:R:I56	R:R:L135	2.85	Yes	No	0	6	3
60	R:R:I56	R:R:S138	4.64	Yes	No	2	6	5
61	R:R:C111	R:R:F57	5.59	No	Yes	0	6	7
62	R:R:F57	R:R:I112	5.02	Yes	No	0	7	8
63	R:R:F57	R:R:R115	3.21	Yes	Yes	2	7	8
64	R:R:D134	R:R:F57	3.58	Yes	Yes	2	8	7
65	R:R:F57	R:R:S138	2.64	Yes	No	2	7	5
66	R:R:I59	R:R:I63	2.94	No	No	0	5	5
67	R:R:F108	R:R:N60	14.5	No	No	2	7	9
68	R:R:N60	R:R:S138	5.96	No	No	2	9	5
69	R:R:N60	R:R:W142	6.78	No	Yes	2	9	9
70	R:R:L109	R:R:L61	2.77	No	No	0	8	9
71	R:R:A64	R:R:W142	2.59	No	Yes	0	8	9
72	R:R:D65	R:R:S105	4.42	Yes	No	0	9	9
73	R:R:D65	R:R:S285	4.42	Yes	No	0	9	8
74	R:R:D288	R:R:D65	6.65	No	Yes	0	9	9
75	R:R:L67	R:R:N101	10.98	No	No	0	7	8
76	R:R:K98	R:R:Q68	4.07	Yes	No	0	6	7
77	R:R:N101	R:R:Q68	3.96	No	No	0	8	7
78	R:R:Q68	R:R:S285	2.89	No	No	0	7	8
79	R:R:S285	R:R:V69	3.23	No	No	0	8	5
80	R:R:R75	R:R:S71	2.64	Yes	No	0	6	7
81	R:R:L97	R:R:S71	3	No	No	0	5	7
82	R:R:L74	R:R:W84	7.97	No	Yes	0	6	8
83	R:R:K98	R:R:R75	9.9	Yes	Yes	1	6	6
84	R:R:F169	R:R:R75	13.9	Yes	Yes	1	4	6
85	L:L:?1	R:R:R75	8.41	Yes	Yes	1	0	6
86	R:R:F77	R:R:N81	12.08	No	No	0	4	3
87	R:R:W84	R:R:Y78	3.86	Yes	Yes	1	8	5
88	R:R:C168	R:R:Y78	4.03	Yes	Yes	1	9	5
89	R:R:F169	R:R:Y78	3.09	Yes	Yes	1	4	5
90	R:R:D171	R:R:Y78	5.75	No	Yes	1	4	5
91	R:R:F169	R:R:Y79	3.09	Yes	Yes	1	4	5
92	R:R:V170	R:R:Y79	7.57	Yes	Yes	1	5	5
93	L:L:?1	R:R:Y79	5.41	Yes	Yes	1	0	5
94	R:R:D83	R:R:R165	11.91	No	No	0	4	3
95	R:R:F86	R:R:W84	12.03	No	Yes	0	6	8
96	R:R:G87	R:R:W84	2.81	No	Yes	0	7	8
97	R:R:L90	R:R:W84	3.42	No	Yes	0	5	8
98	R:R:C91	R:R:W84	3.92	No	Yes	1	9	8
99	R:R:C168	R:R:W84	15.67	Yes	Yes	1	9	8
100	R:R:F169	R:R:W84	4.01	Yes	Yes	1	4	8
101	R:R:F86	R:R:P85	7.22	No	No	0	6	3
102	R:R:P85	R:R:R165	4.32	No	No	0	3	3
103	R:R:G87	R:R:P88	4.06	No	No	0	7	3
104	R:R:C168	R:R:C91	7.28	Yes	No	1	9	9
105	R:R:C91	R:R:F169	2.79	No	Yes	1	9	4
106	R:R:M92	R:R:T157	3.01	No	No	0	7	4
107	R:R:C94	R:R:F169	4.19	No	Yes	0	4	4
108	R:R:F95	R:R:Y99	3.09	No	No	1	5	4
109	R:R:F95	R:R:R156	7.48	No	Yes	1	5	5
110	L:L:?1	R:R:F95	8.44	Yes	No	1	0	5
111	R:R:V100	R:R:Y96	8.83	No	No	0	4	5
112	R:R:C146	R:R:Y96	2.69	No	No	0	4	5
113	R:R:P153	R:R:Y96	2.78	No	No	0	4	5
114	R:R:L97	R:R:N101	2.75	No	No	0	5	8
115	R:R:K98	R:R:S282	3.06	Yes	No	0	6	6
116	R:R:F152	R:R:Y99	11.35	No	No	1	3	4
117	L:L:?1	R:R:Y99	11.73	Yes	No	1	0	4
118	R:R:C149	R:R:V100	3.42	No	No	0	7	4
119	R:R:H247	R:R:Y103	6.53	Yes	No	0	8	7
120	L:L:?1	R:R:Y103	8.12	Yes	No	0	0	7
121	R:R:A104	R:R:W142	3.89	No	Yes	0	7	9
122	R:R:I106	R:R:P197	3.39	No	No	0	7	9
123	R:R:F243	R:R:I106	11.3	Yes	No	0	9	7
124	R:R:F108	R:R:Y107	8.25	No	Yes	0	7	5
125	R:R:C111	R:R:Y107	2.69	No	Yes	0	6	5
126	R:R:G141	R:R:Y107	5.79	No	Yes	0	7	5
127	R:R:F108	R:R:W142	7.02	No	Yes	2	7	9
128	R:R:L109	R:R:Y292	4.69	No	Yes	0	8	9
129	R:R:I112	R:R:R116	3.76	No	No	0	8	9
130	R:R:S113	R:R:V201	3.23	No	No	0	9	8
131	R:R:F119	R:R:R115	3.21	No	Yes	2	8	8
132	R:R:F126	R:R:R115	3.21	No	Yes	2	5	8
133	R:R:D134	R:R:R115	5.96	Yes	Yes	2	8	8
134	R:R:I232	R:R:R116	5.01	No	No	0	7	9
135	R:R:R116	R:R:Y292	4.12	No	Yes	0	9	9
136	R:R:C204	R:R:F117	11.17	No	No	0	6	8
137	R:R:F117	R:R:K207	4.96	No	Yes	0	8	4
138	R:R:F117	R:R:T208	3.89	No	No	0	8	8
139	R:R:W118	R:R:Y122	5.79	No	Yes	0	5	7
140	R:R:F126	R:R:W118	7.02	No	No	0	5	5
141	R:R:F119	R:R:L120	4.87	No	No	0	8	8
142	R:R:F119	R:R:F126	11.79	No	No	2	8	5
143	R:R:L120	R:R:L212	2.77	No	No	0	8	8
144	R:R:M121	R:R:Y122	8.38	No	Yes	0	7	7
145	R:R:K207	R:R:M121	2.88	Yes	No	0	4	7
146	R:R:M121	R:R:S211	7.67	No	No	0	7	4
147	R:R:R125	R:R:Y122	7.2	No	Yes	0	5	7
148	R:R:C129	R:R:H127	2.95	No	No	0	3	5
149	R:R:H127	R:R:K130	5.24	No	No	0	5	7
150	R:R:D128	R:R:Q131	2.61	No	No	0	5	3
151	R:R:D134	R:R:Q131	7.83	Yes	No	0	8	3
152	R:R:K132	R:R:Y133	21.5	No	No	0	4	4
153	R:R:Y133	R:R:Y136	8.94	No	No	0	4	1
154	L:L:?1	R:R:I145	3.3	Yes	No	0	0	8
155	R:R:L154	R:R:V150	2.98	No	No	0	4	4
156	L:L:?1	R:R:F152	9.37	Yes	No	1	0	3
157	R:R:L155	R:R:M185	2.83	No	No	0	4	4
158	R:R:L172	R:R:R156	6.07	No	Yes	0	4	5
159	R:R:R156	R:R:T174	3.88	Yes	No	1	5	3
160	R:R:K257	R:R:R156	7.43	Yes	Yes	1	5	5
161	L:L:?1	R:R:R156	11.22	Yes	Yes	1	0	5
162	R:R:S158	R:R:T161	3.2	No	No	0	5	1
163	R:R:P173	R:R:S158	5.34	No	No	0	5	5
164	R:R:D159	R:R:D160	2.66	No	No	0	1	3
165	R:R:G163	R:R:N164	3.39	No	No	0	3	6
166	R:R:K167	R:R:T166	4.5	No	No	0	4	4
167	R:R:C168	R:R:F169	11.17	Yes	Yes	1	9	4
168	R:R:D171	R:R:V170	4.38	No	Yes	1	4	5
169	L:L:?1	R:R:V170	3.44	Yes	Yes	1	0	5
170	R:R:L172	R:R:P173	3.28	No	No	0	4	5
171	R:R:F254	R:R:T174	2.59	Yes	No	0	4	3
172	R:R:K257	R:R:T174	3	Yes	No	1	5	3
173	R:R:S182	R:R:V177	4.85	No	No	0	4	2
174	R:R:N178	R:R:Q181	3.96	No	No	0	1	4
175	R:R:E260	R:R:L179	10.6	No	No	0	3	3
176	R:R:F254	R:R:M186	7.46	Yes	No	0	4	4
177	R:R:E190	R:R:H247	6.15	No	Yes	0	5	8
178	R:R:E190	R:R:F250	5.83	No	Yes	0	5	5
179	R:R:F194	R:R:L198	3.65	No	No	0	8	6
180	R:R:F194	R:R:H247	20.36	No	Yes	0	8	8
181	R:R:L199	R:R:V195	2.98	No	No	0	3	4
182	R:R:P197	R:R:T196	3.5	No	No	0	9	5
183	R:R:L198	R:R:L202	2.77	No	No	0	6	3
184	R:R:L198	R:R:L240	2.77	No	No	0	6	5
185	R:R:W206	R:R:Y203	3.86	No	No	5	3	3
186	R:R:K207	R:R:Y203	9.55	Yes	No	5	4	3
187	R:R:I232	R:R:T205	4.56	No	No	0	7	9
188	R:R:A236	R:R:T205	3.36	No	No	0	7	9
189	R:R:K207	R:R:W206	6.96	Yes	No	5	4	3
190	R:R:L229	R:R:V209	2.98	No	No	0	5	5
191	R:R:L233	R:R:V209	2.98	No	No	0	5	5
192	R:R:M218	R:R:Y216	11.97	No	No	0	2	4
193	R:R:M218	R:R:Q220	6.8	No	No	0	2	4
194	R:R:D221	R:R:G223	3.35	No	No	0	5	3
195	R:R:D221	R:R:E224	6.5	No	No	0	5	5
196	R:R:E224	R:R:L222	6.63	No	No	0	5	4
197	R:R:C235	R:R:Y292	8.06	No	Yes	0	7	9
198	R:R:I291	R:R:V238	4.61	No	No	0	7	6
199	R:R:F239	R:R:F243	4.29	No	Yes	0	9	9
200	R:R:C242	R:R:N284	9.45	No	No	0	7	9
201	R:R:F243	R:R:N284	8.46	Yes	No	0	9	9
202	R:R:H247	R:R:Y246	7.62	Yes	Yes	0	8	6
203	R:R:F250	R:R:Y246	6.19	Yes	Yes	1	5	6
204	R:R:H274	R:R:Y246	7.62	Yes	Yes	1	5	6
205	R:R:L278	R:R:Y246	4.69	No	Yes	0	5	6
206	L:L:?1	R:R:Y246	3.61	Yes	Yes	1	0	6
207	R:R:F273	R:R:S249	5.28	No	No	0	5	4
208	R:R:H274	R:R:S249	6.97	Yes	No	0	5	4
209	R:R:F250	R:R:P251	4.33	Yes	No	0	5	6
210	L:L:?1	R:R:F250	5.62	Yes	Yes	1	0	5
211	R:R:I270	R:R:L252	4.28	No	No	0	4	4
212	R:R:D253	R:R:K257	5.53	No	Yes	0	4	5
213	R:R:D253	R:R:H274	22.69	No	Yes	0	4	5
214	L:L:?1	R:R:F254	4.69	Yes	Yes	0	0	4
215	R:R:E260	R:R:L255	3.98	No	No	0	3	4
216	R:R:I261	R:R:L255	2.85	No	No	0	1	4
217	R:R:I261	R:R:V256	3.07	No	Yes	0	1	2
218	R:R:R267	R:R:V256	3.92	No	Yes	0	3	2
219	R:R:I270	R:R:V256	4.61	No	Yes	0	4	2
220	R:R:L271	R:R:V256	2.98	No	Yes	0	3	2
221	L:L:?1	R:R:K257	8.68	Yes	Yes	1	0	5
222	R:R:E260	R:R:S258	5.75	No	No	0	3	2
223	R:R:N259	R:R:R267	3.62	No	No	0	1	3
224	L:L:?1	R:R:H274	5.94	Yes	Yes	1	0	5
225	R:R:D288	R:R:N284	5.39	No	No	0	9	9
226	R:R:P289	R:R:Y293	9.74	No	Yes	0	9	7
227	R:R:F294	R:R:P289	2.89	Yes	No	0	7	9
228	R:R:I291	R:R:Y292	3.63	No	Yes	0	7	9
229	R:R:F299	R:R:Y293	5.16	Yes	Yes	4	8	7
230	R:R:F294	R:R:F299	7.5	Yes	Yes	0	7	8
231	R:R:F299	R:R:T296	3.89	Yes	No	0	8	8
232	R:R:N297	R:R:R301	3.62	No	No	0	6	5
233	R:R:E298	R:R:R301	4.65	No	No	0	6	5
234	R:R:E298	R:R:R302	8.14	No	No	3	6	5
235	R:R:F243	R:R:M102	2.49	Yes	No	0	9	7
236	R:R:V43	R:R:W42	2.45	No	No	0	7	3
237	R:R:F254	R:R:L155	2.44	Yes	No	0	4	4
238	R:R:I76	R:R:Y26	2.42	No	Yes	0	7	8
239	R:R:I137	R:R:Y107	2.42	No	Yes	0	5	5
240	R:R:C286	R:R:G33	1.96	No	No	0	7	8
241	R:R:A140	R:R:G141	1.95	No	No	0	3	7
242	R:R:A236	R:R:G237	1.95	No	No	0	7	4
243	R:R:A244	R:R:P245	1.87	No	No	0	5	9
244	R:R:A277	R:R:P245	1.87	No	No	0	6	9
245	R:R:G163	R:R:T161	1.82	No	No	0	3	1
246	R:R:P197	R:R:V110	1.77	No	No	0	9	7
247	R:R:G163	R:R:K167	1.74	No	No	0	3	4
248	R:R:C204	R:R:S113	1.72	No	No	0	6	9
249	R:R:A277	R:R:S249	1.71	No	No	0	6	4
250	R:R:A266	R:R:S263	1.71	No	No	0	1	6
251	R:R:M92	R:R:P153	1.68	No	No	0	7	4
252	R:R:L72	R:R:P73	1.64	No	No	0	8	9
253	R:R:C149	R:R:I145	1.64	No	No	0	7	8
254	R:R:C204	R:R:I200	1.64	No	No	0	6	7
255	R:R:G223	R:R:Q226	1.64	No	No	0	3	4
256	R:R:L280	R:R:P245	1.64	No	No	0	7	9
257	R:R:A266	R:R:I261	1.62	No	No	0	1	1
258	R:R:T27	R:R:V28	1.59	No	No	0	5	4
259	R:R:T187	R:R:V183	1.59	No	No	0	4	3
260	R:R:T205	R:R:V209	1.59	No	No	0	9	5
261	R:R:T234	R:R:V238	1.59	No	No	0	5	6
262	R:R:A23	R:R:L80	1.58	No	No	0	5	4
263	R:R:A228	R:R:L212	1.58	No	No	0	7	8
264	R:R:A62	R:R:N37	1.56	No	Yes	0	8	9
265	R:R:A180	R:R:N178	1.56	No	No	0	1	1
266	R:R:I200	R:R:V114	1.54	No	No	0	7	6
267	R:R:I188	R:R:V184	1.54	No	No	0	4	2
268	R:R:M186	R:R:S182	1.53	No	No	0	4	4
269	R:R:M48	R:R:V55	1.52	No	Yes	0	5	7
270	R:R:F294	R:R:G36	1.51	Yes	No	0	7	8
271	R:R:L265	R:R:S263	1.5	No	No	0	2	6
272	R:R:L265	R:R:V269	1.49	No	No	0	2	3
273	R:R:L191	R:R:T187	1.47	No	No	0	4	4
274	R:R:I188	R:R:I192	1.47	No	No	0	4	4
275	R:R:F77	R:R:P85	1.44	No	No	0	4	3
276	R:R:I38	R:R:L66	1.43	No	No	0	3	7
277	R:R:I76	R:R:L80	1.43	No	No	0	7	4
278	R:R:L151	R:R:M185	1.41	No	No	0	8	4
279	R:R:P123	R:R:Y122	1.39	No	Yes	0	8	7
280	R:R:P217	R:R:Y216	1.39	No	No	0	3	4
281	R:R:L67	R:R:L70	1.38	No	No	0	7	5
282	R:R:D214	R:R:K215	1.38	No	No	0	5	5
283	R:R:K225	R:R:Q226	1.36	No	No	0	6	4
284	R:R:L210	R:R:Q213	1.33	No	No	0	4	4
285	R:R:A281	R:R:Y246	1.33	No	Yes	0	8	6
286	L:L:?1	R:R:G189	1.32	Yes	No	0	0	5
287	L:L:?1	R:R:G193	1.32	Yes	No	0	0	5
288	R:R:R175	R:R:V177	1.31	No	No	0	4	2
289	R:R:I272	R:R:R268	1.25	No	No	0	1	2
290	R:R:N297	R:R:R300	1.21	No	No	0	6	8
291	R:R:L210	R:R:W206	1.14	No	No	0	4	3
292	L:L:?1	R:R:I192	1.1	Yes	No	0	0	4
293	R:R:F194	R:R:F248	1.07	No	No	0	8	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:R18	3.56	4	1	4
2	R:R:Y19	5.10833	6	1	5
3	R:R:Y22	5.325	6	1	6
4	R:R:Y26	3.97167	6	1	8
5	R:R:N37	3.575	4	0	9
6	R:R:F44	4.0125	4	4	6
7	R:R:Y47	6.068	5	3	5
8	R:R:V55	2.8175	4	0	7
9	R:R:I56	4.4575	4	2	6
10	R:R:F57	4.59667	6	2	7
11	R:R:D65	5.555	4	0	9
12	R:R:R75	7.794	5	1	6
13	R:R:Y78	4.14	5	1	5
14	R:R:Y79	6.988	5	1	5
15	R:R:W84	6.71125	8	1	8
16	R:R:K98	5.1525	4	1	6
17	R:R:Y107	4.7875	4	0	5
18	R:R:R115	3.8975	4	2	8
19	R:R:Y122	5.69	4	0	7
20	R:R:D134	5.0425	4	2	8
21	R:R:W142	5.07	4	2	9
22	R:R:R156	7.216	5	1	5
23	R:R:C168	9.5375	4	1	9
24	R:R:F169	6.03429	7	1	4
25	R:R:V170	4.36	5	1	5
26	R:R:K207	6.0875	4	5	4
27	R:R:F243	6.635	4	0	9
28	R:R:Y246	5.17667	6	1	6
29	R:R:H247	10.165	4	0	8
30	R:R:F250	5.4925	4	1	5
31	R:R:F254	4.295	4	0	4
32	R:R:V256	3.645	4	0	2
33	R:R:K257	6.16	4	1	5
34	R:R:H274	10.805	4	1	5
35	R:R:Y292	5.125	4	0	9
36	R:R:Y293	5.8325	4	4	7
37	R:R:F294	3.8875	4	0	7
38	R:R:F299	6.48	5	4	8
39	L:L:?1	5.68632	19	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L271	R:R:R18	19.7653	4.86	No	Yes	0	3	4
2	R:R:Y22	R:R:Y26	14.9519	3.97	Yes	Yes	1	6	8
3	L:L:?1	R:R:Y26	37.4952	2.71	Yes	Yes	1	0	8
4	L:L:?1	R:R:V170	10.6464	3.44	Yes	Yes	1	0	5
5	R:R:F169	R:R:R75	16.5564	13.9	Yes	Yes	1	4	6
6	L:L:?1	R:R:R75	41.5044	8.41	Yes	Yes	1	0	6
7	R:R:K98	R:R:Y26	52.8319	3.58	Yes	Yes	1	6	8
8	R:R:K98	R:R:R75	47.703	9.9	Yes	Yes	1	6	6
9	R:R:F294	R:R:P289	11.2312	2.89	Yes	No	0	7	9
10	R:R:N37	R:R:P289	89.9538	3.26	Yes	No	0	9	9
11	R:R:D65	R:R:N37	93.1166	6.73	Yes	Yes	0	9	9
12	R:R:D65	R:R:S285	98.611	4.42	Yes	No	0	9	8
13	R:R:Q68	R:R:S285	99.419	2.89	No	No	0	7	8
14	R:R:K98	R:R:Q68	100	4.07	Yes	No	0	6	7
15	R:R:P289	R:R:Y293	78.2878	9.74	No	Yes	0	9	7
16	R:R:F44	R:R:Y293	73.2089	3.09	Yes	Yes	4	6	7
17	R:R:F44	R:R:V55	75.5329	2.62	Yes	Yes	0	6	7
18	R:R:V55	R:R:Y47	72.6741	2.52	Yes	Yes	0	7	5
19	R:R:R53	R:R:Y47	66.3332	4.12	No	Yes	3	6	5
20	R:R:D128	R:R:R53	65.7676	5.96	No	No	0	5	6
21	R:R:D134	R:R:F57	30.3925	3.58	Yes	Yes	2	8	7
22	R:R:D134	R:R:Q131	64.3132	7.83	Yes	No	0	8	3
23	R:R:D128	R:R:Q131	65.1212	2.61	No	No	0	5	3
24	R:R:F57	R:R:I112	19.065	5.02	Yes	No	0	7	8
25	R:R:D134	R:R:R115	24.8403	5.96	Yes	Yes	2	8	8
26	R:R:N60	R:R:S138	11.4044	5.96	No	No	2	9	5
27	R:R:I112	R:R:R116	17.9184	3.76	No	No	0	8	9
28	R:R:D288	R:R:D65	12.6549	6.65	No	Yes	0	9	9
29	R:R:C149	R:R:I145	10.9311	1.64	No	No	0	7	8
30	L:L:?1	R:R:I145	12.3432	3.3	Yes	No	0	0	8
31	L:L:?1	R:R:R156	14.9442	11.22	Yes	Yes	1	0	5
32	L:L:?1	R:R:Y103	10.1616	8.12	Yes	No	0	0	7
33	L:L:?1	R:R:Y246	13.2282	3.61	Yes	Yes	1	0	6
34	R:R:D288	R:R:N284	11.4236	5.39	No	No	0	9	9
35	R:R:K207	R:R:M121	14.7249	2.88	Yes	No	0	4	7
36	R:R:M121	R:R:Y122	17.072	8.38	No	Yes	0	7	7
37	R:R:W118	R:R:Y122	20.5348	5.79	No	Yes	0	5	7
38	R:R:F126	R:R:W118	21.6737	7.02	No	No	0	5	5
39	R:R:F126	R:R:R115	22.3394	3.21	No	Yes	2	5	8
40	L:L:?1	R:R:F254	13.3936	4.69	Yes	Yes	0	0	4
41	R:R:L172	R:R:R156	12.4971	6.07	No	Yes	0	4	5
42	R:R:L172	R:R:P173	11.0927	3.28	No	No	0	4	5
43	R:R:I261	R:R:V256	12.1855	3.07	No	Yes	0	1	2
44	R:R:L271	R:R:V256	18.688	2.98	No	Yes	0	3	2
45	R:R:F194	R:R:H247	15.1558	20.36	No	Yes	0	8	8
46	L:L:?1	R:R:H274	11.7507	5.94	Yes	Yes	1	0	5
47	R:R:R18	R:R:Y22	13.9092	4.12	Yes	Yes	1	4	6
48	R:R:F169	R:R:W84	13.3282	4.01	Yes	Yes	1	4	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:R18	R:R:Y22	4.12	1	Yes	Yes	4	6	2	1
R:R:R18	R:R:V170	2.62	1	Yes	Yes	4	5	2	1
R:R:R18	R:R:S275	2.64	1	Yes	No	4	4	2	2
R:R:Y19	R:R:Y79	8.94	1	Yes	Yes	5	5	2	1
R:R:V170	R:R:Y19	3.79	1	Yes	Yes	5	5	1	2
R:R:D171	R:R:Y19	4.6	1	No	Yes	4	5	2	2
R:R:Y22	R:R:Y26	3.97	1	Yes	Yes	6	8	1	1
R:R:Y22	R:R:Y79	9.93	1	Yes	Yes	6	5	1	1
R:R:S275	R:R:Y22	7.63	1	No	Yes	4	6	2	1
R:R:C279	R:R:Y22	2.69	0	No	Yes	5	6	2	1
L:L:?1	R:R:Y22	3.61	1	Yes	Yes	0	6	0	1
R:R:L72	R:R:Y26	7.03	0	No	Yes	8	8	2	1
R:R:R75	R:R:Y26	4.12	1	Yes	Yes	6	8	1	1
R:R:K98	R:R:Y26	3.58	1	Yes	Yes	6	8	2	1
L:L:?1	R:R:Y26	2.71	1	Yes	Yes	0	8	0	1
R:R:R75	R:R:S71	2.64	1	Yes	No	6	7	1	2
R:R:K98	R:R:R75	9.9	1	Yes	Yes	6	6	2	1
R:R:F169	R:R:R75	13.9	1	Yes	Yes	4	6	2	1
L:L:?1	R:R:R75	8.41	1	Yes	Yes	0	6	0	1
R:R:F169	R:R:Y79	3.09	1	Yes	Yes	4	5	2	1
R:R:V170	R:R:Y79	7.57	1	Yes	Yes	5	5	1	1
L:L:?1	R:R:Y79	5.41	1	Yes	Yes	0	5	0	1
R:R:F95	R:R:Y99	3.09	1	No	No	5	4	1	1
R:R:F95	R:R:R156	7.48	1	No	Yes	5	5	1	1
L:L:?1	R:R:F95	8.44	1	Yes	No	0	5	0	1
R:R:F152	R:R:Y99	11.35	1	No	No	3	4	1	1
L:L:?1	R:R:Y99	11.73	1	Yes	No	0	4	0	1
R:R:H247	R:R:Y103	6.53	0	Yes	No	8	7	2	1
L:L:?1	R:R:Y103	8.12	1	Yes	No	0	7	0	1
L:L:?1	R:R:I145	3.3	1	Yes	No	0	8	0	1
L:L:?1	R:R:F152	9.37	1	Yes	No	0	3	0	1
R:R:L172	R:R:R156	6.07	0	No	Yes	4	5	2	1
R:R:R156	R:R:T174	3.88	1	Yes	No	5	3	1	2
R:R:K257	R:R:R156	7.43	1	Yes	Yes	5	5	1	1
L:L:?1	R:R:R156	11.22	1	Yes	Yes	0	5	0	1
R:R:D171	R:R:V170	4.38	1	No	Yes	4	5	2	1
L:L:?1	R:R:V170	3.44	1	Yes	Yes	0	5	0	1
R:R:F254	R:R:T174	2.59	0	Yes	No	4	3	1	2
R:R:K257	R:R:T174	3	1	Yes	No	5	3	1	2
R:R:F254	R:R:M186	7.46	0	Yes	No	4	4	1	2
R:R:E190	R:R:H247	6.15	0	No	Yes	5	8	2	2
R:R:E190	R:R:F250	5.83	0	No	Yes	5	5	2	1
R:R:H247	R:R:Y246	7.62	0	Yes	Yes	8	6	2	1
R:R:F250	R:R:Y246	6.19	1	Yes	Yes	5	6	1	1
R:R:H274	R:R:Y246	7.62	1	Yes	Yes	5	6	1	1
R:R:L278	R:R:Y246	4.69	0	No	Yes	5	6	2	1
L:L:?1	R:R:Y246	3.61	1	Yes	Yes	0	6	0	1
R:R:H274	R:R:S249	6.97	1	Yes	No	5	4	1	2
R:R:F250	R:R:P251	4.33	1	Yes	No	5	6	1	2
L:L:?1	R:R:F250	5.62	1	Yes	Yes	0	5	0	1
R:R:D253	R:R:K257	5.53	0	No	Yes	4	5	2	1
R:R:D253	R:R:H274	22.69	0	No	Yes	4	5	2	1
L:L:?1	R:R:F254	4.69	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:K257	8.68	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:H274	5.94	1	Yes	Yes	0	5	0	1
R:R:F254	R:R:L155	2.44	0	Yes	No	4	4	1	2
R:R:I76	R:R:Y26	2.42	0	No	Yes	7	8	2	1
R:R:C149	R:R:I145	1.64	0	No	No	7	8	2	1
R:R:I188	R:R:I192	1.47	0	No	No	4	4	2	1
R:R:A281	R:R:Y246	1.33	0	No	Yes	8	6	2	1
L:L:?1	R:R:G189	1.32	1	Yes	No	0	5	0	1
L:L:?1	R:R:G193	1.32	1	Yes	No	0	5	0	1
L:L:?1	R:R:I192	1.1	1	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XV3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.52
Number of Linked Nodes	267
Number of Links	293
Number of Hubs	39
Number of Links mediated by Hubs	149
Number of Communities	5
Number of Nodes involved in Communities	46
Number of Links involved in Communities	74

Path Summary
Number Of Nodes in MetaPath	49
Number Of Links MetaPath	48
Number of Shortest Paths	43963
Length Of Smallest Path	3
Average Path Length	14.8608
Length of Longest Path	34
Minimum Path Strength	1.235
Average Path Strength	5.01363
Maximum Path Strength	15.22
Minimum Path Correlation	0.7
Average Path Correlation	0.923131
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	47.1732
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.6986
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • bioactive lipid receptor activity • multicellular organismal process • multicellular organismal-level homeostasis • leukocyte homeostasis • T cell homeostasis • homeostatic process • immune system process • homeostasis of number of cells • lymphocyte homeostasis • negative regulation of biological process • negative regulation of interleukin-2 production • regulation of cytokine production • cytokine production • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of interleukin-2 production • negative regulation of metabolic process • interleukin-2 production • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • intracellular membraneless organelle • centrosome • microtubule organizing center • cytoskeleton • centriolar satellite • membraneless organelle • microtubule cytoskeleton
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	WJS
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	WJS
Name	(2~{S})-2-$l^{4}-azanyl-3-[[(2~{R})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid
Synonyms
Identifier
Formula	C24 H20 N O9 P
Molecular Weight	497.391
SMILES
PubChem
Formal Charge	0
Total Atoms	55
Total Chiral Atoms	2
Total Bonds	54
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9BXC1
Sequence	>7XV3_nogp_Chain_R T D F R Y F I Y A V T Y T V I L V P G L I G N I L A L W V F Y G Y M K E T K R A V I F M I N L A I A D L L Q V L S L P L R I F Y Y L N H D W P F G P G L C M F C F Y L K Y V N M Y A S I Y F L V C I S V R R F W F L M Y P F R F H D C K Q K Y D L Y I S I A G W L I I C L A C V L F P L L R T S D D T S G N R T K C F V D L P T R N V N L A Q S V V M M T I G E L I G F V T P L L I V L Y C T W K T V L S L Q D K Y P M A Q D L G E K Q K A L K M I L T C A G V F L I C F A P Y H F S F P L D F L V K S N E I K S C L A R R V I L I F H S V A L C L A S L N S C L D P V I Y Y F S T N E F R R R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XV3	A	Orphan	Orphan	GPR174	Homo sapiens	Lysophosphatidylserine	-	chim(NtGi1-Gs)/β1/γ2	2.76	2023-02-15	doi.org/10.1038/s41467-023-36575-0
	7XV3 (No Gprot)	A	Orphan	Orphan	GPR174	Homo sapiens	Lysophosphatidylserine	-		2.76	2023-02-15	doi.org/10.1038/s41467-023-36575-0
	8KH5	A	Orphan	Orphan	GPR174	Homo sapiens	Lysophosphatidylserine	-	Gs/β1/γ2	2.83	2023-10-11	doi.org/10.1038/s41467-023-41654-3
	8KH5 (No Gprot)	A	Orphan	Orphan	GPR174	Homo sapiens	Lysophosphatidylserine	-		2.83	2023-10-11	doi.org/10.1038/s41467-023-41654-3
	8IZB	A	Orphan	Orphan	GPR174	Homo sapiens	Lysophosphatidylserine	-	Gs/β1/γ2	3.06	2023-11-01	doi.org/10.1371/journal.pbio.3002387
	8IZB (No Gprot)	A	Orphan	Orphan	GPR174	Homo sapiens	Lysophosphatidylserine	-		3.06	2023-11-01	doi.org/10.1371/journal.pbio.3002387

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