Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Y62 6.838548
2R:R:E81 6.05754108
3R:R:F108 2.585618
4R:R:M111 3.674529
5R:R:L112 4.5275419
6R:R:Q114 4.5429
7R:R:R119 7.37519
8R:R:D126 3.722519
9R:R:W129 12.7817618
10R:R:Y130 3.852519
11R:R:L133 3.955409
12R:R:R135 4.935439
13R:R:R146 8.8725409
14R:R:F151 4.455419
15R:R:P154 5.144267
16R:R:L197 4.4725429
17R:R:R200 8.7225429
18R:R:Y220 5.86833628
19R:R:V221 2.944528
20R:R:P231 4.9425405
21R:R:F233 6.0325109
22R:R:L234 5.355449
23R:R:R242 4.5754108
24R:R:W245 5.03125848
25R:R:L246 4.64109
26R:R:T252 5.02428
27R:R:F253 5.628509
28R:R:Y254 5.824529
29R:R:K257 9.2975429
30R:R:P262 5.756529
31R:R:M270 2.9825409
32R:R:W288 5.04333646
33R:R:Y289 4.075445
34R:R:H293 7.2825408
35R:R:S299 3.855409
36R:R:Q308 5.5725406
37R:R:F310 6.456549
38R:R:L312 5.15333649
39R:R:Y315 4.95409
40R:R:L354 4.83407
41R:R:L357 5.044115
42R:R:C359 3.68254119
43R:R:S365 3.66254118
44R:R:P371 2.83754289
45R:R:V374 7.01754187
46R:R:R381 4.0075409
47R:R:V384 3.834298
48R:R:Q388 5.664149
49R:R:M392 3.34149
50R:R:L423 3.622509
51R:R:F426 5.084508
52R:R:L428 3.1385149
53R:R:Y430 6.14149
54R:R:F431 3.47254148
55R:R:W450 8.224209
56R:R:L454 2.67254208
57R:R:F456 11.276558
58R:R:Y460 13.96459
59R:R:Y468 5.7975485
60R:R:W508 8.574509
61R:R:R515 5.45254154
62R:R:P521 6.5045155
63R:R:L522 6.33754159
64R:R:I524 3.17754195
65R:R:T528 4.674509
66R:R:R532 8.58754189
67R:R:D540 5.26754159
68R:R:V547 3.855459
69R:R:E550 4.89459
70R:R:L554 3.944559
71R:R:G557 2.5925489
72R:R:L560 4.358589
73R:R:H582 6.4075489
74R:R:E584 6.5275459
75R:R:F591 11.535459
76R:R:H592 5.988559
77R:R:F596 4.874559
78R:R:H603 9.5585188
79R:R:F611 4.045457
80R:R:F612 4.4575409
81R:R:V619 4.32409
82R:R:F627 4.6375408
83R:R:W632 7.7775401
84S:S:Y62 6.838568
85S:S:E81 6.05754128
86S:S:F108 2.585618
87S:S:M111 3.674539
88S:S:L112 4.5275419
89S:S:Q114 4.5439
90S:S:R119 7.37519
91S:S:D126 3.722519
92S:S:W129 12.7817618
93S:S:Y130 3.852519
94S:S:L133 3.955409
95S:S:R135 5.24429
96S:S:R146 8.8725409
97S:S:F151 4.455419
98S:S:P154 5.144317
99S:S:L175 3.6425409
100S:S:L197 4.4725439
101S:S:R200 7.6325439
102S:S:Y220 5.86833638
103S:S:V221 2.66538
104S:S:P231 4.9425405
105S:S:F233 6.0325129
106S:S:L234 5.355469
107S:S:R242 4.5754128
108S:S:W245 5.03125868
109S:S:L246 4.64129
110S:S:T252 5.02438
111S:S:F253 5.628509
112S:S:Y254 5.824539
113S:S:K257 9.2975439
114S:S:P262 5.756539
115S:S:M270 2.9825409
116S:S:W288 4.84666
117S:S:Y289 4.075465
118S:S:H293 7.2825408
119S:S:S299 3.855409
120S:S:Q308 5.5725406
121S:S:F310 6.456569
122S:S:L312 5.15333669
123S:S:Y315 4.95409
124S:S:L354 4.83407
125S:S:L357 5.044135
126S:S:C359 3.68254139
127S:S:S365 3.66254138
128S:S:P371 3.714339
129S:S:V374 7.01754217
130S:S:R381 4.0075409
131S:S:V384 3.834348
132S:S:Q388 5.664169
133S:S:M392 3.34169
134S:S:L423 3.622509
135S:S:F426 5.084508
136S:S:L428 3.1385169
137S:S:Y430 6.14169
138S:S:F431 3.47254168
139S:S:W450 8.224239
140S:S:L454 2.67254238
141S:S:F456 11.276578
142S:S:Y460 13.96479
143S:S:Y468 5.7975495
144S:S:W508 8.574509
145S:S:R515 5.45254174
146S:S:P521 6.5045175
147S:S:L522 6.33754179
148S:S:I524 3.17754225
149S:S:T528 4.674509
150S:S:R532 8.58754219
151S:S:D540 5.26754179
152S:S:V547 3.855479
153S:S:E550 4.89479
154S:S:L554 3.944579
155S:S:G557 2.5925499
156S:S:L560 4.358599
157S:S:E584 6.5275479
158S:S:F591 11.535479
159S:S:H592 5.988579
160S:S:F596 4.874579
161S:S:H603 9.5585218
162S:S:F611 4.045477
163S:S:F612 4.4575409
164S:S:V619 4.32409
165S:S:F627 4.6375408
166S:S:W632 8.43401
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:L312 R:R:L63 88.80594.15YesNo099
2R:R:L63 R:R:W245 88.7024.56NoYes098
3R:R:G313 R:R:L312 49.53541.71NoYes489
4R:R:P231 R:R:P232 81.58811.95YesNo059
5R:R:P232 R:R:W245 81.7782.7NoYes498
6R:R:P231 R:R:S230 81.71423.56YesNo059
7R:R:F310 R:R:I279 10.678913.82YesNo499
8R:R:F310 R:R:W288 11.88077.02YesYes496
9R:R:P92 R:R:W288 13.93444.05NoYes096
10R:R:L95 R:R:P92 13.43719.85NoNo099
11R:R:L91 R:R:L95 12.58652.77NoNo059
12R:R:L91 R:R:Q96 12.5153.99NoNo054
13R:R:G97 R:R:Q96 12.48411.64NoNo064
14R:R:G97 S:S:G97 12.47592.11NoNo066
15R:R:L102 R:R:V268 10.26764.47NoNo069
16R:R:L149 R:R:V268 11.12162.98NoNo099
17R:R:L149 R:R:Y130 12.98362.34NoYes099
18R:R:F253 R:R:L109 26.452112.18YesNo099
19R:R:F253 R:R:G266 48.74326.02YesNo098
20R:R:G266 R:R:N152 48.31655.09NoNo086
21R:R:N152 R:R:V264 51.31742.96NoNo068
22R:R:T252 R:R:V264 50.16023.17YesNo288
23R:R:Q267 R:R:T252 75.34944.25NoYes288
24R:R:Q267 R:R:Q269 76.17393.84NoNo087
25R:R:Q269 R:R:T248 76.38142.83NoNo078
26R:R:S230 R:R:T248 81.14124.8NoNo098
27R:R:F151 R:R:F253 10.06235.36YesYes099
28R:R:L133 R:R:S136 11.08734.5YesNo099
29R:R:L109 R:R:L133 21.21944.15NoYes099
30R:R:F108 S:S:S136 11.27992.64YesNo089
31R:R:F108 R:R:L133 14.24162.44YesYes089
32R:R:F108 R:R:L112 11.97732.44YesYes189
33R:R:L112 R:R:L113 18.74122.77YesNo099
34R:R:F253 R:R:L113 17.87482.44YesNo099
35R:R:T252 R:R:Y254 25.24037.49YesYes289
36R:R:L197 R:R:Y254 15.32649.38YesYes299
37R:R:F108 S:S:F108 15.4673.22YesYes188
38R:R:S136 S:S:F108 11.24622.64NoYes098
39R:R:G219 R:R:Y220 12.12312.9NoYes298
40R:R:G219 R:R:M111 12.37161.75NoYes299
41R:R:M111 S:S:R135 19.92123.72YesYes299
42R:R:L149 R:R:V134 14.65244.47NoNo099
43R:R:L175 R:R:V134 19.45874.47NoNo099
44S:S:F108 S:S:L112 11.93372.44YesYes189
45R:R:L175 R:R:R135 19.34266.07NoYes099
46R:R:R135 S:S:M111 18.7853.72YesYes399
47S:S:G97 S:S:Q96 12.47921.64NoNo064
48S:S:L91 S:S:Q96 12.50673.99NoNo054
49S:S:L91 S:S:L95 12.57382.77NoNo059
50S:S:L95 S:S:P92 13.40799.85NoNo099
51S:S:P92 S:S:W288 13.90374.05NoYes096
52S:S:P231 S:S:S230 80.53413.56YesNo059
53S:S:S230 S:S:T248 79.96124.8NoNo098
54S:S:L175 S:S:R135 20.45096.07YesYes099
55R:R:C282 R:R:P304 99.324911.3NoNo099
56R:R:C282 R:R:C302 99.39837.28NoNo099
57R:R:C302 R:R:H293 99.478313.27NoYes098
58R:R:H293 R:R:Y315 1004.36YesYes089
59R:R:Q281 R:R:Y315 49.95899.02NoYes099
60R:R:L312 R:R:Q281 49.61219.32YesNo099
61R:R:G313 R:R:Y315 50.22912.9NoYes089
62R:R:G330 R:R:G331 98.8492.11NoNo028
63R:R:G331 R:R:L332 98.8991.71NoNo084
64R:R:L316 R:R:L332 99.00118.3NoNo064
65R:R:L316 R:R:V303 99.05335.96NoNo067
66R:R:P304 R:R:V303 99.11493.53NoNo097
67R:R:A326 R:R:G330 95.17471.95NoNo052
68R:R:A326 R:R:G325 95.12271.95NoNo055
69R:R:G325 R:R:S365 94.65631.86NoYes1158
70R:R:P360 R:R:S365 96.54353.56NoYes1188
71R:R:P360 R:R:T364 97.45912.24NoNo085
72R:R:E361 R:R:T364 96.77675.64NoNo085
73R:R:E361 R:R:R532 96.73019.3NoYes089
74R:R:E375 R:R:R532 48.05438.14NoYes1879
75R:R:R532 R:R:V374 48.26249.15YesYes1897
76R:R:H603 R:R:V374 47.92939.69YesYes1887
77R:R:E375 R:R:H603 47.92958.62NoYes1878
78R:R:D605 R:R:R381 94.46047.15NoYes099
79R:R:D605 R:R:H603 94.95688.82NoYes098
80R:R:L608 R:R:R381 92.64572.43NoYes099
81R:R:L608 R:R:V384 51.21314.47NoYes098
82R:R:F612 R:R:V384 50.65527.87YesYes098
83R:R:C387 R:R:F612 52.07914.19NoYes059
84R:R:C387 S:S:C390 51.97651.82NoNo058
85R:R:F612 R:R:Q388 32.91923.51YesYes099
86R:R:M392 R:R:Q388 12.64694.08YesYes1499
87R:R:Q388 R:R:Y430 19.17667.89YesYes1499
88R:R:C390 S:S:C390 51.95347.28NoNo088
89R:R:C390 S:S:C387 51.97041.82NoNo085
90R:R:L436 R:R:L608 56.8744.15NoNo099
91R:R:V619 R:R:Y430 18.961410.09YesYes099
92R:R:F426 R:R:V619 14.09192.62YesYes089
93R:R:F611 R:R:L436 51.33753.65YesNo079
94R:R:F591 R:R:F611 48.99927.5YesYes597
95R:R:F591 R:R:H592 34.838310.18YesYes599
96R:R:F596 R:R:H592 17.38633.39YesYes599
97R:R:D543 R:R:F596 16.52513.58NoYes599
98R:R:D543 R:R:R449 16.087311.91NoNo099
99R:R:R449 R:R:W508 15.644711NoYes099
100R:R:F591 R:R:H614 13.974826.02YesNo099
101R:R:H614 R:R:T618 13.57415.48NoNo099
102R:R:E584 R:R:L554 14.91226.63YesYes599
103R:R:G557 R:R:L581 20.72961.71YesNo099
104R:R:L554 R:R:L581 24.3032.77YesNo099
105S:S:C387 S:S:F612 52.07274.19NoYes059
106S:S:F612 S:S:Q388 33.05743.51YesYes099
107S:S:M392 S:S:Q388 13.00344.08YesYes1699
108S:S:L427 S:S:M392 10.21154.24NoYes099
109S:S:F310 S:S:W288 11.96247.02YesYes696
110S:S:F310 S:S:I279 10.751713.82YesNo699
111S:S:I279 S:S:L312 10.54032.85NoYes699
112S:S:L63 S:S:W245 87.64184.56NoYes098
113S:S:G313 S:S:L312 49.04311.71NoYes689
114S:S:P232 S:S:W245 80.72012.7NoYes698
115S:S:L175 S:S:V134 20.58094.47YesNo099
116S:S:L149 S:S:V134 15.42734.47NoNo099
117S:S:L149 S:S:V268 11.14862.98NoNo099
118S:S:L102 S:S:V268 10.29254.47NoNo069
119S:S:F108 S:S:L133 14.2232.44YesYes089
120S:S:L133 S:S:S136 11.06314.5YesNo099
121S:S:L109 S:S:L133 21.11224.15NoYes099
122S:S:L149 S:S:Y130 13.60642.34NoYes099
123S:S:L112 S:S:L113 18.29852.77YesNo099
124S:S:F253 S:S:L113 17.41132.44YesNo099
125S:S:F253 S:S:L109 26.58212.18YesNo099
126S:S:G219 S:S:M111 11.58941.75NoYes399
127S:S:G219 S:S:Y220 11.34352.9NoYes398
128S:S:F253 S:S:G266 48.84266.02YesNo098
129S:S:G266 S:S:N152 48.41355.09NoNo086
130S:S:N152 S:S:V264 52.11182.96NoNo068
131S:S:L197 S:S:Y254 14.55519.38YesYes399
132S:S:Q269 S:S:T248 75.90042.83NoNo078
133S:S:Q267 S:S:Q269 75.6973.84NoNo087
134S:S:Q267 S:S:T252 74.87844.25NoYes388
135S:S:T252 S:S:Y254 24.0377.49YesYes389
136S:S:L312 S:S:Q281 49.11949.32YesNo099
137S:S:Q281 S:S:Y315 49.46649.02NoYes099
138S:S:H293 S:S:Y315 99.01544.36YesYes089
139S:S:C302 S:S:H293 98.492913.27NoYes098
140S:S:C282 S:S:C302 98.41237.28NoNo099
141S:S:C282 S:S:P304 98.338311.3NoNo099
142S:S:G313 S:S:Y315 49.73632.9NoYes089
143S:S:P304 S:S:V303 98.12653.53NoNo097
144S:S:L316 S:S:V303 98.06425.96NoNo067
145S:S:L316 S:S:L332 98.01158.3NoNo064
146S:S:G331 S:S:L332 97.90821.71NoNo084
147S:S:G330 S:S:G331 97.85762.11NoNo028
148S:S:A326 S:S:G330 94.1821.95NoNo052
149S:S:A326 S:S:G325 94.12951.95NoNo055
150S:S:G325 S:S:S365 93.66241.86NoYes1358
151S:S:P360 S:S:S365 95.53683.56NoYes1388
152S:S:P360 S:S:T364 96.44812.24NoNo085
153S:S:E361 S:S:T364 95.7065.64NoNo085
154S:S:E361 S:S:R532 95.65859.3NoYes089
155S:S:E375 S:S:R532 47.51468.14NoYes2179
156S:S:R532 S:S:V374 47.72289.15YesYes2197
157S:S:H603 S:S:V374 47.38929.69YesYes2187
158S:S:E375 S:S:H603 47.38938.62NoYes2178
159S:S:F612 S:S:V384 51.47377.87YesYes098
160S:S:L608 S:S:V384 52.02474.47NoYes098
161S:S:L608 S:S:R381 91.58572.43NoYes099
162S:S:D605 S:S:R381 93.37967.15NoYes099
163S:S:Q388 S:S:Y430 18.95677.89YesYes1699
164S:S:V619 S:S:Y430 18.738610.09YesYes099
165S:S:F426 S:S:V619 14.10012.62YesYes089
166S:S:L436 S:S:L608 55.22944.15NoNo099
167S:S:F611 S:S:L436 49.68733.65YesNo079
168S:S:F591 S:S:F611 47.3457.5YesYes797
169S:S:F591 S:S:H592 33.734210.18YesYes799
170S:S:F596 S:S:H592 17.39123.39YesYes799
171S:S:D543 S:S:F596 16.52513.58NoYes799
172S:S:D543 S:S:R449 16.087311.91NoNo099
173S:S:R449 S:S:W508 15.644711NoYes099
174S:S:L554 S:S:L581 22.12752.77YesNo099
175S:S:G557 S:S:L581 18.51941.71YesNo099
176S:S:F591 S:S:H614 13.423526.02YesNo099
177S:S:H614 S:S:T618 13.02235.48NoNo099
178R:R:I279 R:R:L312 10.46682.85NoYes499
179S:S:T252 S:S:V264 50.90323.17YesNo388
180S:S:D605 S:S:H603 93.87428.82NoYes098
181S:S:F151 S:S:F253 10.62535.36YesYes099
182S:S:E584 S:S:L554 13.78666.63YesYes799
183S:S:P231 S:S:P232 80.52951.95YesNo059
184S:S:L312 S:S:L63 87.74564.15YesNo099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8IRJ
Class C
SubFamily Orphan
Type Orphan
SubType GPR179
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.49
Date 2024-09-18
D.O.I. To be published
Net Summary
Imin 1.71
Number of Linked Nodes 992
Number of Links 1158
Number of Hubs 166
Number of Links mediated by Hubs 595
Number of Communities 35
Number of Nodes involved in Communities 258
Number of Links involved in Communities 346
Path Summary
Number Of Nodes in MetaPath 185
Number Of Links MetaPath 184
Number of Shortest Paths 2147019
Length Of Smallest Path 3
Average Path Length 40.1653
Length of Longest Path 69
Minimum Path Strength 1.25
Average Path Strength 5.36294
Maximum Path Strength 29.815
Minimum Path Correlation 0.7
Average Path Correlation 0.991811
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.17391
Average % Of Corr. Nodes 48.6397
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 37.4988
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component• cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ6PRD1
Sequence
>8IRJ_Chain_R
GAEAALAYL YSGDAQQLS QVNCSERYE ARGAGAMPG LPPSLQGAA 
GTLAQAANF LNMLLQAND IRESSVEED VEWYQALVR SVAEGDPRV 
YRALLTFNP PPGASHLQL ALQATRTGE ETILQDLSG NWVQETPAL 
KKRVLTNDL GPQADGYVG DTQQVRLSP PFLECQEGR LRPGWLITL 
SATFYGLKP DLSPEVRGQ VQMDVDLQS VDINQCASG PGWYSNTHL 
CDLNSTQCV PLESQGFVL GRYLCRCRP GFYGASPSG GLGRLLQCL 
PCPEGCTSC MDATPCLVE EAAVLRAAV LACQACCML AIFLSMLVS 
YRCRRNKGV VLLETVLFG FLLLYFPVF ILYFKPSVF RCIALRWVR 
LLGFAIVYG TIILKLYRV LQLFLSSAL LSSGRLLRR LGLLLLPVL 
GFLAVWTVG ALERGIQHA PLVIRGHTP SGRHFYLCH HDRWDYIMV 
VAELLLLCW GSFLCYATR FHEPRYMGI ALHNELLLS AAFHTARFV 
LVPSLHPDW TLLLFFFHT HSTVTTTLA LIFIPKFWK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtQ6PRD1
Sequence
>8IRJ_Chain_S
GAEAALAYL YSGDAQQLS QVNCSERYE ARGAGAMPG LPPSLQGAA 
GTLAQAANF LNMLLQAND IRESSVEED VEWYQALVR SVAEGDPRV 
YRALLTFNP PPGASHLQL ALQATRTGE ETILQDLSG NWVQETPAL 
KKRVLTNDL GPQADGYVG DTQQVRLSP PFLECQEGR LRPGWLITL 
SATFYGLKP DLSPEVRGQ VQMDVDLQS VDINQCASG PGWYSNTHL 
CDLNSTQCV PLESQGFVL GRYLCRCRP GFYGASPSG GLGRLLQCL 
PCPEGCTSC MDATPCLVE EAAVLRAAV LACQACCML AIFLSMLVS 
YRCRRNKGV VLLETVLFG FLLLYFPVF ILYFKPSVF RCIALRWVR 
LLGFAIVYG TIILKLYRV LQLFLSSAL LSSGRLLRR LGLLLLPVL 
GFLAVWTVG ALERGIQHA PLVIRGHTP SGRHFYLCH HDRWDYIMV 
VAELLLLCW GSFLCYATR FHEPRYMGI ALHNELLLS AAFHTARFV 
LVPSLHPDW TLLLFFFHT HSTVTTTLA LIFIPKFWK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IRJCOrphanOrphanGPR179Homo sapiens---3.492024-09-18To be published




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