psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G49	R:R:V52	3.68	No	No	0	6	5
2	R:R:I54	R:R:L50	2.85	Yes	No	4	5	4
3	R:R:F303	R:R:L50	2.44	No	No	4	5	4
4	R:R:I54	R:R:Y58	6.04	Yes	Yes	0	5	7
5	R:R:I54	R:R:R302	3.76	Yes	No	0	5	4
6	R:R:F303	R:R:I54	5.02	No	Yes	4	5	5
7	R:R:G108	R:R:V55	3.68	No	Yes	0	6	4
8	R:R:I111	R:R:V55	3.07	Yes	Yes	0	4	4
9	R:R:L112	R:R:V55	11.92	No	Yes	0	4	4
10	R:R:G56	R:R:L59	3.42	No	No	0	5	4
11	R:R:L57	R:R:V61	2.98	No	No	0	5	7
12	R:R:I111	R:R:Y58	4.84	Yes	Yes	0	4	7
13	R:R:T305	R:R:Y58	2.5	No	Yes	0	5	7
14	R:R:A306	R:R:Y58	2.67	No	Yes	0	4	7
15	R:R:C313	R:R:V61	3.42	No	No	0	7	7
16	R:R:C62	R:R:L66	3.17	No	No	0	6	6
17	R:R:C62	R:R:L104	4.76	No	No	0	6	7
18	R:R:C62	R:R:P105	3.77	No	No	0	6	8
19	R:R:L66	R:R:T98	2.95	No	No	0	6	7
20	R:R:L101	R:R:L66	5.54	No	No	0	5	6
21	R:R:D97	R:R:N69	6.73	Yes	No	0	9	9
22	R:R:N69	R:R:T98	4.39	No	No	0	9	7
23	R:R:N69	R:R:P316	6.52	No	No	0	9	9
24	R:R:I76	R:R:V72	3.07	Yes	Yes	0	7	9
25	R:R:A320	R:R:V72	3.39	No	Yes	0	7	9
26	R:R:F321	R:R:V72	2.62	No	Yes	0	6	9
27	R:R:F91	R:R:M73	7.46	No	No	0	5	7
28	R:R:L95	R:R:M73	7.07	No	No	0	6	7
29	R:R:R78	R:R:Y74	6.17	No	No	0	5	4
30	R:R:H79	R:R:V75	6.92	No	No	0	5	7
31	R:R:F326	R:R:V75	5.24	No	No	0	8	7
32	R:R:I76	R:R:I90	2.94	Yes	No	0	7	8
33	R:R:F91	R:R:I76	3.77	No	Yes	0	5	7
34	R:R:F326	R:R:I76	2.51	No	Yes	0	8	7
35	R:R:L77	R:R:R78	2.43	No	No	0	3	5
36	R:R:F91	R:R:L77	3.65	No	No	0	5	3
37	R:R:F333	R:R:H79	5.66	No	No	0	4	5
38	R:R:M82	R:R:T80	4.52	No	No	5	7	5
39	R:R:C329	R:R:T80	5.07	No	No	5	5	5
40	R:R:M82	R:R:N87	5.61	No	No	0	7	8
41	R:R:C329	R:R:M82	3.24	No	No	5	5	7
42	R:R:I88	R:R:K83	4.36	No	No	0	6	7
43	R:R:K83	R:R:S164	6.12	No	No	0	7	3
44	R:R:N87	R:R:T84	8.77	No	No	0	8	7
45	R:R:A85	R:R:Y89	2.67	No	Yes	0	6	7
46	R:R:I90	R:R:T86	3.04	No	No	0	8	8
47	R:R:I88	R:R:N171	2.83	No	No	0	6	7
48	R:R:M144	R:R:Y89	5.99	No	Yes	0	9	7
49	R:R:D147	R:R:Y89	6.9	No	Yes	0	8	7
50	R:R:A167	R:R:Y89	5.34	No	Yes	0	7	7
51	R:R:V170	R:R:Y89	2.52	No	Yes	0	5	7
52	R:R:N171	R:R:Y89	6.98	No	Yes	0	7	7
53	R:R:N92	R:R:T140	5.85	No	No	0	9	7
54	R:R:N171	R:R:N92	8.17	No	No	0	7	9
55	R:R:N92	R:R:W175	12.43	No	No	0	9	9
56	R:R:D97	R:R:L93	6.79	Yes	No	2	9	9
57	R:R:L141	R:R:L93	5.54	No	No	0	8	9
58	R:R:L93	R:R:N315	2.75	No	No	2	9	9
59	R:R:A96	R:R:S137	3.42	No	No	0	8	9
60	R:R:D97	R:R:S137	2.94	Yes	No	0	9	9
61	R:R:D97	R:R:N315	8.08	Yes	No	2	9	9
62	R:R:L99	R:R:N133	13.73	No	No	0	7	8
63	R:R:V100	R:R:Y309	2.52	No	Yes	0	7	6
64	R:R:Q107	R:R:T103	4.25	No	No	0	5	6
65	R:R:D130	R:R:T103	11.56	No	No	0	6	6
66	R:R:L104	R:R:Y309	8.21	No	Yes	0	7	6
67	R:R:F106	R:R:F118	12.86	No	Yes	0	6	6
68	R:R:F106	R:R:V126	2.62	No	No	0	6	5
69	L:L:F4	R:R:Q107	9.37	Yes	No	0	0	5
70	R:R:F118	R:R:T109	5.19	Yes	No	0	6	4
71	R:R:D110	R:R:W116	8.93	No	Yes	0	4	8
72	L:L:F4	R:R:D110	2.39	Yes	No	0	0	4
73	L:L:R8	R:R:D110	3.57	No	No	0	0	4
74	R:R:I111	R:R:R302	11.27	Yes	No	0	4	4
75	R:R:F115	R:R:L113	3.65	No	No	6	4	5
76	R:R:L113	R:R:P117	3.28	No	No	6	5	3
77	R:R:F115	R:R:P117	8.67	No	No	6	4	3
78	R:R:E197	R:R:F115	3.5	No	No	0	2	4
79	R:R:F118	R:R:W116	22.05	Yes	Yes	0	6	8
80	R:R:G119	R:R:W116	2.81	No	Yes	0	7	8
81	R:R:C123	R:R:W116	5.22	No	Yes	1	9	8
82	R:R:V126	R:R:W116	2.45	No	Yes	0	5	8
83	R:R:C200	R:R:W116	14.37	Yes	Yes	1	9	8
84	R:R:F118	R:R:P117	2.89	Yes	No	0	6	3
85	R:R:F118	R:R:L122	6.09	Yes	No	0	6	6
86	R:R:K124	R:R:N120	8.39	No	No	0	6	2
87	R:R:N120	R:R:S190	4.47	No	No	0	2	3
88	R:R:C123	R:R:C200	7.28	No	Yes	1	9	9
89	R:R:I129	R:R:T125	3.04	No	No	0	4	5
90	L:L:F4	R:R:V126	2.62	Yes	No	0	0	5
91	R:R:I127	R:R:Y131	2.42	Yes	Yes	1	4	4
92	R:R:C200	R:R:I127	3.27	Yes	Yes	1	9	4
93	R:R:I127	R:R:V202	3.07	Yes	Yes	1	4	4
94	L:L:F4	R:R:I127	5.02	Yes	Yes	1	0	4
95	R:R:I129	R:R:N133	2.83	No	No	0	4	8
96	R:R:D130	R:R:Y309	6.9	No	Yes	0	6	6
97	R:R:V185	R:R:Y131	2.52	No	Yes	1	4	4
98	R:R:V202	R:R:Y131	2.52	Yes	Yes	1	4	4
99	L:L:F1	R:R:Y131	8.25	Yes	Yes	0	0	4
100	R:R:N133	R:R:Y132	3.49	No	Yes	0	8	5
101	R:R:W175	R:R:Y132	10.61	No	Yes	0	9	5
102	R:R:A178	R:R:Y132	2.67	No	Yes	0	8	5
103	R:R:S179	R:R:Y132	7.63	No	Yes	0	4	5
104	R:R:M134	R:R:W276	6.98	No	Yes	0	7	8
105	L:L:F1	R:R:M134	9.95	Yes	No	0	0	7
106	R:R:F135	R:R:V181	5.24	No	No	0	6	5
107	R:R:T136	R:R:W175	14.55	No	No	0	6	9
108	R:R:P227	R:R:T138	3.5	No	No	0	8	7
109	R:R:I174	R:R:T140	3.04	No	No	0	6	7
110	R:R:F272	R:R:L141	2.44	Yes	No	0	9	8
111	R:R:L141	R:R:Y319	8.21	No	Yes	0	8	9
112	R:R:P227	R:R:T142	3.5	No	No	0	8	8
113	R:R:M144	R:R:Y319	2.39	No	Yes	0	9	9
114	R:R:I231	R:R:S145	9.29	No	No	7	8	9
115	R:R:S145	R:R:Y235	8.9	No	Yes	7	9	9
116	R:R:D147	R:R:R162	5.96	No	No	0	8	5
117	R:R:R148	R:R:Y235	4.12	No	Yes	0	9	9
118	R:R:R148	R:R:Y319	3.09	No	Yes	0	9	9
119	R:R:C153	R:R:Y149	6.72	No	No	0	7	8
120	R:R:C234	R:R:Y149	12.1	No	No	0	7	8
121	R:R:L237	R:R:Y149	7.03	No	No	0	4	8
122	R:R:A151	R:R:R162	5.53	No	No	0	8	5
123	R:R:I152	R:R:M238	7.29	No	No	0	8	8
124	R:R:I152	R:R:L242	2.85	No	No	0	8	8
125	R:R:C153	R:R:H154	4.42	No	No	0	7	6
126	R:R:C153	R:R:R241	2.79	No	No	0	7	5
127	R:R:D160	R:R:V161	4.38	No	No	0	3	4
128	R:R:K166	R:R:T163	9.01	No	No	0	4	7
129	R:R:P184	R:R:V183	3.53	No	No	0	7	4
130	R:R:I187	R:R:V183	3.07	No	No	0	4	4
131	R:R:V185	R:R:V202	3.21	No	Yes	1	4	4
132	R:R:F215	R:R:V185	3.93	No	No	0	6	4
133	R:R:M188	R:R:V202	3.04	No	Yes	0	5	4
134	R:R:F215	R:R:M188	2.49	No	No	0	6	5
135	R:R:E203	R:R:S190	8.62	No	No	0	1	3
136	R:R:E194	R:R:Q192	5.1	Yes	No	3	1	2
137	L:L:K9	R:R:Q192	2.71	Yes	No	3	0	2
138	R:R:I198	R:R:V193	7.68	No	No	0	4	2
139	L:L:K9	R:R:E194	5.4	Yes	Yes	3	0	1
140	L:L:K13	R:R:E194	5.4	No	Yes	3	0	1
141	R:R:E199	R:R:L201	2.65	Yes	No	0	2	3
142	L:L:R8	R:R:E199	12.79	No	Yes	0	0	2
143	L:L:K9	R:R:E199	12.15	Yes	Yes	0	0	2
144	L:L:F4	R:R:C200	5.59	Yes	Yes	1	0	9
145	R:R:I204	R:R:P205	3.39	No	No	0	5	4
146	R:R:I204	R:R:Q208	5.49	No	No	0	5	5
147	R:R:P205	R:R:W211	5.4	No	No	0	4	4
148	R:R:P207	R:R:W211	5.4	No	No	0	4	4
149	R:R:W211	R:R:Y210	2.89	No	No	0	4	3
150	R:R:G212	R:R:P213	4.06	No	No	0	3	3
151	R:R:F215	R:R:I219	6.28	No	No	0	6	4
152	R:R:I217	R:R:L221	2.85	No	No	0	5	4
153	L:L:F1	R:R:I219	2.51	Yes	No	0	0	4
154	R:R:F220	R:R:I225	3.77	No	No	0	5	4
155	R:R:F220	R:R:Q280	7.03	No	Yes	0	5	7
156	R:R:F220	R:R:L284	10.96	No	No	0	5	5
157	R:R:I225	R:R:L221	2.85	No	No	0	4	4
158	R:R:Q280	R:R:S223	10.11	Yes	No	0	7	6
159	R:R:F224	R:R:I225	3.77	Yes	No	0	8	4
160	R:R:F224	R:R:V228	3.93	Yes	Yes	0	8	6
161	R:R:F224	R:R:T277	3.89	Yes	No	0	8	6
162	R:R:F224	R:R:Q280	5.86	Yes	Yes	0	8	7
163	R:R:P227	R:R:V226	3.53	No	No	0	8	5
164	R:R:F272	R:R:V228	2.62	Yes	Yes	0	9	6
165	R:R:V228	R:R:V273	3.21	Yes	No	0	6	6
166	R:R:L229	R:R:V233	2.98	No	No	0	4	5
167	R:R:I231	R:R:Y235	2.42	No	Yes	7	8	9
168	R:R:M238	R:R:Y235	4.79	No	Yes	0	8	9
169	R:R:V265	R:R:Y235	6.31	No	Yes	0	7	9
170	R:R:V269	R:R:Y235	2.52	No	Yes	0	7	9
171	R:R:L237	R:R:R240	3.64	No	No	0	4	3
172	R:R:I239	R:R:T262	12.16	No	No	0	5	6
173	R:R:R241	R:R:V245	2.62	No	No	0	5	6
174	R:R:L242	R:R:L248	5.54	No	No	0	8	3
175	R:R:L247	R:R:V245	4.47	No	No	0	5	6
176	R:R:L248	R:R:L258	2.77	No	No	0	3	6
177	R:R:G250	R:R:K254	3.49	No	No	0	4	3
178	R:R:K254	R:R:S251	9.18	No	No	0	3	3
179	R:R:E253	R:R:R256	11.63	No	No	0	3	4
180	R:R:D255	R:R:L258	2.71	No	No	0	3	6
181	R:R:N257	R:R:R260	3.62	No	No	0	5	8
182	R:R:I261	R:R:N257	2.83	No	No	0	7	5
183	R:R:L258	R:R:T262	2.95	No	No	0	6	6
184	R:R:V268	R:R:Y319	2.52	No	Yes	0	8	9
185	R:R:N311	R:R:V271	2.96	Yes	No	0	9	6
186	R:R:F272	R:R:W276	5.01	Yes	Yes	2	9	8
187	R:R:F272	R:R:N311	4.83	Yes	Yes	2	9	9
188	R:R:C275	R:R:N311	7.87	No	Yes	0	8	9
189	R:R:N311	R:R:W276	7.91	Yes	Yes	2	9	8
190	R:R:S312	R:R:W276	2.47	No	Yes	0	8	8
191	R:R:P278	R:R:T277	3.5	No	No	0	9	6
192	R:R:C304	R:R:P278	3.77	No	No	0	6	9
193	L:L:F1	R:R:V279	2.62	Yes	No	0	0	6
194	L:L:F1	R:R:Q280	4.68	Yes	Yes	0	0	7
195	R:R:F282	R:R:Q286	7.03	No	No	0	5	4
196	R:R:F282	R:R:L301	10.96	No	No	0	5	4
197	L:L:F1	R:R:V283	7.87	Yes	No	0	0	5
198	R:R:P292	R:R:Q286	9.47	Yes	No	0	4	4
199	L:L:T5	R:R:Q286	5.67	No	No	0	0	4
200	L:L:S10	R:R:Q291	7.22	No	No	0	0	6
201	L:L:L14	R:R:S293	6.01	No	No	0	0	1
202	R:R:S294	R:R:T296	4.8	No	No	0	1	3
203	R:R:L301	R:R:T305	2.95	No	No	0	4	5
204	R:R:T305	R:R:Y309	2.5	No	Yes	0	5	6
205	R:R:L314	R:R:N311	2.75	No	Yes	0	6	9
206	R:R:N311	R:R:N315	5.45	Yes	No	2	9	9
207	R:R:I317	R:R:L314	2.85	No	No	0	6	6
208	R:R:L314	R:R:L318	6.92	No	No	0	6	8
209	R:R:F321	R:R:I317	3.77	No	No	0	6	6
210	R:R:F321	R:R:F326	3.22	No	No	0	6	8
211	R:R:E324	R:R:K327	5.4	No	No	0	5	8
212	R:R:K327	R:R:R331	3.71	No	No	0	8	4
213	R:R:F330	R:R:R331	4.28	No	No	0	5	4
214	R:R:F333	R:R:K332	2.48	No	No	0	4	5
215	L:L:K13	L:L:K9	7.18	No	Yes	3	0	0
216	R:R:D255	R:R:R259	2.38	No	No	0	3	4
217	R:R:E324	R:R:R260	2.33	No	No	0	5	8
218	R:R:G64	R:R:G65	2.11	No	No	0	5	7
219	L:L:G2	L:L:G3	2.11	No	No	0	0	0
220	R:R:C313	R:R:G65	1.96	No	No	0	7	7
221	R:R:A216	R:R:G287	1.95	No	No	0	4	4
222	R:R:A297	R:R:P292	1.87	No	Yes	0	3	4
223	L:L:A7	R:R:P292	1.87	No	Yes	0	0	4
224	R:R:G182	R:R:V181	1.84	No	No	0	7	5
225	R:R:G308	R:R:V279	1.84	No	No	0	7	6
226	L:L:G2	R:R:V283	1.84	No	No	0	0	5
227	L:L:G6	L:L:T5	1.82	No	No	0	0	0
228	R:R:A191	R:R:C123	1.81	No	No	0	4	9
229	R:R:A128	R:R:A186	1.79	No	No	0	5	4
230	L:L:S10	R:R:P292	1.78	No	Yes	0	0	4
231	R:R:G189	R:R:I127	1.76	No	Yes	0	5	4
232	R:R:G212	R:R:I204	1.76	No	No	0	3	5
233	R:R:P207	R:R:T206	1.75	No	No	0	4	2
234	R:R:G189	R:R:K124	1.74	No	No	0	5	6
235	R:R:G65	R:R:L101	1.71	No	No	0	7	5
236	R:R:G68	R:R:L67	1.71	No	No	0	8	4
237	R:R:C218	R:R:V214	1.71	No	No	0	3	3
238	R:R:C234	R:R:V230	1.71	No	No	0	7	7
239	R:R:A297	R:R:S294	1.71	No	No	0	3	1
240	R:R:A94	R:R:V72	1.7	No	Yes	0	9	9
241	L:L:A11	R:R:V298	1.7	No	No	0	0	3
242	R:R:M188	R:R:P205	1.68	No	No	0	5	4
243	R:R:C304	R:R:I300	1.64	No	No	0	6	4
244	R:R:S164	R:R:S165	1.63	No	No	0	3	4
245	R:R:A143	R:R:I174	1.62	No	No	0	7	6
246	R:R:A191	R:R:I198	1.62	No	No	0	4	4
247	R:R:S232	R:R:V228	1.62	No	Yes	0	4	6
248	R:R:S232	R:R:V269	1.62	No	No	0	4	7
249	R:R:V146	R:R:V150	1.6	No	No	0	7	5
250	R:R:V146	R:R:V230	1.6	No	No	0	7	7
251	R:R:V150	R:R:V161	1.6	No	No	0	5	4
252	R:R:V226	R:R:V230	1.6	No	No	0	5	7
253	R:R:V267	R:R:V271	1.6	No	No	0	6	6
254	R:R:T80	R:R:V75	1.59	No	No	0	5	7
255	R:R:T277	R:R:V281	1.59	No	No	0	6	6
256	R:R:A299	R:R:L50	1.58	No	No	0	1	4
257	R:R:H154	R:R:P155	1.53	No	No	0	6	7
258	R:R:K51	R:R:V52	1.52	No	No	0	4	5
259	R:R:M134	R:R:T138	1.51	No	No	0	7	7
260	L:L:R8	R:R:G114	1.5	No	No	0	0	4
261	R:R:G244	R:R:R241	1.5	No	No	0	4	5
262	R:R:L59	R:R:V55	1.49	No	Yes	0	4	4
263	R:R:L237	R:R:V233	1.49	No	No	0	4	5
264	R:R:L264	R:R:V268	1.49	No	No	0	8	8
265	R:R:I111	R:R:K51	1.45	Yes	No	0	4	4
266	R:R:D323	R:R:T86	1.45	No	No	0	8	8
267	R:R:E253	R:R:S251	1.44	No	No	0	3	3
268	R:R:I261	R:R:L242	1.43	No	No	0	7	8
269	R:R:L102	R:R:L99	1.38	No	No	0	4	7
270	R:R:A158	R:R:R162	1.38	No	No	0	6	5
271	R:R:L264	R:R:L322	1.38	No	No	0	8	6
272	R:R:D323	R:R:N325	1.35	No	No	0	8	6
273	L:L:L14	R:R:Q291	1.33	No	No	0	0	6
274	R:R:F135	R:R:S223	1.32	No	No	0	6	6
275	R:R:R263	R:R:V267	1.31	No	No	0	6	6
276	R:R:R302	R:R:V298	1.31	No	No	0	4	3
277	R:R:D195	R:R:E194	1.3	No	Yes	0	1	1
278	R:R:F139	R:R:I174	1.26	No	No	0	5	6
279	R:R:I239	R:R:R243	1.25	No	No	0	5	5
280	L:L:R12	R:R:E199	1.16	No	Yes	0	0	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I54	4.4175	4	4	5
2	R:R:V55	5.04	4	0	4
3	R:R:Y58	4.0125	4	0	7
4	R:R:V72	2.695	4	0	9
5	R:R:I76	3.0725	4	0	7
6	R:R:Y89	5.06667	6	0	7
7	R:R:D97	6.135	4	2	9
8	R:R:I111	5.1575	4	0	4
9	R:R:W116	9.305	6	1	8
10	R:R:F118	9.816	5	0	6
11	R:R:I127	3.108	5	1	4
12	R:R:Y131	3.9275	4	1	4
13	R:R:Y132	6.1	4	0	5
14	R:R:E194	4.3	4	3	1
15	R:R:E199	7.1875	4	0	2
16	R:R:C200	7.6275	4	1	9
17	R:R:V202	2.96	4	1	4
18	R:R:F224	4.3625	4	0	8
19	R:R:V228	2.845	4	0	6
20	R:R:Y235	4.84333	6	7	9
21	R:R:F272	3.725	4	2	9
22	R:R:W276	5.5925	4	2	8
23	R:R:Q280	6.92	4	0	7
24	R:R:P292	3.7475	4	0	4
25	R:R:Y309	5.0325	4	0	6
26	R:R:N311	5.295	6	2	9
27	R:R:Y319	4.0525	4	0	9
28	L:L:F1	5.98	6	0	0
29	L:L:F4	4.998	5	1	0
30	L:L:K9	6.86	4	3	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I111	R:R:Y58	33.3529	4.84	Yes	Yes	0	4	7
2	R:R:I54	R:R:Y58	19.3996	6.04	Yes	Yes	0	5	7
3	R:R:I111	R:R:V55	14.6084	3.07	Yes	Yes	0	4	4
4	R:R:T305	R:R:Y58	57.2211	2.5	No	Yes	0	5	7
5	R:R:T305	R:R:Y309	92.8229	2.5	No	Yes	0	5	6
6	R:R:L104	R:R:Y309	58.4727	8.21	No	Yes	0	7	6
7	R:R:C62	R:R:L104	58.5509	4.76	No	No	0	6	7
8	R:R:C62	R:R:L66	59.9003	3.17	No	No	0	6	6
9	R:R:L101	R:R:L66	18.4707	5.54	No	No	0	5	6
10	R:R:G65	R:R:L101	15.4395	1.71	No	No	0	7	5
11	R:R:L66	R:R:T98	65.376	2.95	No	No	0	6	7
12	R:R:D97	R:R:N69	70.0596	6.73	Yes	No	0	9	9
13	R:R:N69	R:R:T98	66.4809	4.39	No	No	0	9	7
14	R:R:D97	R:R:N315	39.5033	8.08	Yes	No	2	9	9
15	R:R:N311	R:R:N315	41.8989	5.45	Yes	No	2	9	9
16	R:R:L314	R:R:N311	99.2764	2.75	No	Yes	0	6	9
17	R:R:I317	R:R:L314	94.8763	2.85	No	No	0	6	6
18	R:R:F321	R:R:I317	92.6469	3.77	No	No	0	6	6
19	R:R:F321	R:R:V72	36.697	2.62	No	Yes	0	6	9
20	R:R:I76	R:R:V72	29.2168	3.07	Yes	Yes	0	7	9
21	R:R:F321	R:R:F326	54.2779	3.22	No	No	0	6	8
22	R:R:F326	R:R:I76	29.5492	2.51	No	Yes	0	8	7
23	R:R:F91	R:R:I76	32.0915	3.77	No	Yes	0	5	7
24	R:R:F91	R:R:M73	10.8243	7.46	No	No	0	5	7
25	R:R:F91	R:R:L77	16.2022	3.65	No	No	0	5	3
26	R:R:L77	R:R:R78	10.8243	2.43	No	No	0	3	5
27	R:R:F326	R:R:V75	24.7287	5.24	No	No	0	8	7
28	R:R:I76	R:R:I90	21.541	2.94	Yes	No	0	7	8
29	R:R:T80	R:R:V75	14.0706	1.59	No	No	0	5	7
30	R:R:D97	R:R:L93	36.2081	6.79	Yes	No	2	9	9
31	R:R:L141	R:R:L93	37.8801	5.54	No	No	0	8	9
32	R:R:L141	R:R:Y319	97.8879	8.21	No	Yes	0	8	9
33	R:R:M144	R:R:Y319	69.1014	2.39	No	Yes	0	9	9
34	R:R:M144	R:R:Y89	67.0676	5.99	No	Yes	0	9	7
35	R:R:N171	R:R:Y89	49.4671	6.98	No	Yes	0	7	7
36	R:R:I88	R:R:N171	10.5114	2.83	No	No	0	6	7
37	R:R:I90	R:R:T86	16.1924	3.04	No	No	0	8	8
38	R:R:D147	R:R:Y89	10.5114	6.9	No	Yes	0	8	7
39	R:R:N171	R:R:N92	37.8312	8.17	No	No	0	7	9
40	R:R:N92	R:R:T140	10.5114	5.85	No	No	0	9	7
41	R:R:N92	R:R:W175	25.7065	12.43	No	No	0	9	9
42	R:R:W175	R:R:Y132	20.7197	10.61	No	Yes	0	9	5
43	R:R:N133	R:R:Y132	13.0928	3.49	No	Yes	0	8	5
44	R:R:D130	R:R:Y309	59.4505	6.9	No	Yes	0	6	6
45	R:R:D130	R:R:T103	59.8709	11.56	No	No	0	6	6
46	R:R:Q107	R:R:T103	61.6016	4.25	No	No	0	5	6
47	L:L:F4	R:R:V126	13.1319	2.62	Yes	No	0	0	5
48	L:L:F4	R:R:Q107	63.1759	9.37	Yes	No	0	0	5
49	R:R:F118	R:R:W116	25.1491	22.05	Yes	Yes	0	6	8
50	L:L:F4	R:R:D110	30.4097	2.39	Yes	No	0	0	4
51	R:R:C200	R:R:W116	21.3357	14.37	Yes	Yes	1	9	8
52	L:L:R8	R:R:D110	25.2762	3.57	No	No	0	0	4
53	R:R:F118	R:R:P117	16.5347	2.89	Yes	No	0	6	3
54	L:L:F4	R:R:I127	61.1714	5.02	Yes	Yes	1	0	4
55	R:R:G189	R:R:I127	12.8483	1.76	No	Yes	0	5	4
56	R:R:G189	R:R:K124	10.3158	1.74	No	No	0	5	6
57	R:R:I127	R:R:Y131	81.5391	2.42	Yes	Yes	1	4	4
58	R:R:I127	R:R:V202	11.0003	3.07	Yes	Yes	1	4	4
59	L:L:F1	R:R:Y131	100	8.25	Yes	Yes	0	0	4
60	L:L:F1	R:R:M134	93.126	9.95	Yes	No	0	0	7
61	R:R:N311	R:R:W276	54.5908	7.91	Yes	Yes	2	9	8
62	R:R:M134	R:R:W276	97.9662	6.98	No	Yes	0	7	8
63	R:R:F135	R:R:S223	10.1985	1.32	No	No	0	6	6
64	R:R:Q280	R:R:S223	13.5621	10.11	Yes	No	0	7	6
65	L:L:F1	R:R:Q280	46.3381	4.68	Yes	Yes	0	0	7
66	R:R:M134	R:R:T138	58.7171	1.51	No	No	0	7	7
67	R:R:P227	R:R:T138	56.2433	3.5	No	No	0	8	7
68	R:R:F272	R:R:L141	74.6064	2.44	Yes	No	0	9	8
69	R:R:F272	R:R:N311	48.4697	4.83	Yes	Yes	2	9	9
70	R:R:R148	R:R:Y319	35.905	3.09	No	Yes	0	9	9
71	R:R:R148	R:R:Y235	34.096	4.12	No	Yes	0	9	9
72	R:R:C153	R:R:Y149	19.5561	6.72	No	No	0	7	8
73	R:R:C234	R:R:Y149	33.0987	12.1	No	No	0	7	8
74	R:R:C234	R:R:V230	35.7485	1.71	No	No	0	7	7
75	R:R:V226	R:R:V230	48.7044	1.6	No	No	0	5	7
76	R:R:P227	R:R:V226	51.2369	3.53	No	No	0	8	5
77	R:R:L237	R:R:Y149	11.411	7.03	No	No	0	4	8
78	R:R:M238	R:R:Y235	53.525	4.79	No	Yes	0	8	9
79	R:R:I152	R:R:M238	50.484	7.29	No	No	0	8	8
80	R:R:I152	R:R:L242	47.5702	2.85	No	No	0	8	8
81	R:R:C153	R:R:R241	11.1959	2.79	No	No	0	7	5
82	R:R:V146	R:R:V230	11.411	1.6	No	No	0	7	7
83	R:R:F215	R:R:M188	16.8573	2.49	No	No	0	6	5
84	R:R:M188	R:R:V202	25.0513	3.04	No	Yes	0	5	4
85	L:L:K9	R:R:E199	13.0537	12.15	Yes	Yes	0	0	2
86	L:L:R8	R:R:E199	20.5339	12.79	No	Yes	0	0	2
87	R:R:M188	R:R:P205	36.7068	1.68	No	No	0	5	4
88	R:R:I204	R:R:P205	16.6129	3.39	No	No	0	5	4
89	R:R:P205	R:R:W211	16.6129	5.4	No	No	0	4	4
90	L:L:F1	R:R:I219	19.869	2.51	Yes	No	0	0	4
91	R:R:F220	R:R:Q280	10.6581	7.03	No	Yes	0	5	7
92	R:R:F224	R:R:Q280	39.249	5.86	Yes	Yes	0	8	7
93	R:R:F224	R:R:I225	11.1079	3.77	Yes	No	0	8	4
94	R:R:F272	R:R:V228	42.4367	2.62	Yes	Yes	0	9	6
95	R:R:F224	R:R:V228	42.4465	3.93	Yes	Yes	0	8	6
96	R:R:F224	R:R:T277	13.9239	3.89	Yes	No	0	8	6
97	R:R:S232	R:R:V228	38.6037	1.62	No	Yes	0	4	6
98	R:R:S232	R:R:V269	35.8267	1.62	No	No	0	4	7
99	R:R:V269	R:R:Y235	33.8125	2.52	No	Yes	0	7	9
100	R:R:L242	R:R:L248	22.9882	5.54	No	No	0	8	3
101	R:R:L248	R:R:L258	19.7614	2.77	No	No	0	3	6
102	R:R:I261	R:R:L242	22.4602	1.43	No	No	0	7	8
103	R:R:I261	R:R:N257	19.517	2.83	No	No	0	7	5
104	R:R:N257	R:R:R260	16.2707	3.62	No	No	0	5	8
105	R:R:F282	R:R:L301	36.2179	10.96	No	No	0	5	4
106	R:R:L301	R:R:T305	38.9361	2.95	No	No	0	4	5
107	R:R:F282	R:R:Q286	33.7245	7.03	No	No	0	5	4
108	R:R:P292	R:R:Q286	25.6576	9.47	Yes	No	0	4	4
109	L:L:S10	R:R:P292	11.6848	1.78	No	Yes	0	0	4
110	R:R:E324	R:R:R260	13.0048	2.33	No	No	0	5	8
111	R:R:R302	R:R:V298	10.9612	1.31	No	No	0	4	3
112	R:R:D323	R:R:T86	10.8047	1.45	No	No	0	8	8
113	R:R:F215	R:R:I219	17.7374	6.28	No	No	0	6	4
114	R:R:V202	R:R:Y131	17.532	2.52	Yes	Yes	1	4	4
115	R:R:C200	R:R:I127	25.4718	3.27	Yes	Yes	1	9	4
116	R:R:F272	R:R:W276	44.4607	5.01	Yes	Yes	2	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:Q107	R:R:T103	4.25	0	No	No	5	6	1	2
R:R:F106	R:R:V126	2.62	0	No	No	6	5	2	1
L:L:F4	R:R:Q107	9.37	1	Yes	No	0	5	0	1
R:R:D110	R:R:W116	8.93	0	No	Yes	4	8	1	2
L:L:F4	R:R:D110	2.39	1	Yes	No	0	4	0	1
L:L:R8	R:R:D110	3.57	0	No	No	0	4	0	1
R:R:C123	R:R:W116	5.22	1	No	Yes	9	8	2	2
R:R:V126	R:R:W116	2.45	0	No	Yes	5	8	1	2
R:R:C200	R:R:W116	14.37	1	Yes	Yes	9	8	1	2
R:R:C123	R:R:C200	7.28	1	No	Yes	9	9	2	1
L:L:F4	R:R:V126	2.62	1	Yes	No	0	5	0	1
R:R:I127	R:R:Y131	2.42	1	Yes	Yes	4	4	1	1
R:R:C200	R:R:I127	3.27	1	Yes	Yes	9	4	1	1
R:R:I127	R:R:V202	3.07	1	Yes	Yes	4	4	1	2
L:L:F4	R:R:I127	5.02	1	Yes	Yes	0	4	0	1
R:R:V185	R:R:Y131	2.52	1	No	Yes	4	4	2	1
R:R:V202	R:R:Y131	2.52	1	Yes	Yes	4	4	2	1
L:L:F1	R:R:Y131	8.25	0	Yes	Yes	0	4	0	1
R:R:M134	R:R:W276	6.98	0	No	Yes	7	8	1	2
L:L:F1	R:R:M134	9.95	0	Yes	No	0	7	0	1
R:R:V185	R:R:V202	3.21	1	No	Yes	4	4	2	2
R:R:F215	R:R:V185	3.93	0	No	No	6	4	2	2
R:R:E194	R:R:Q192	5.1	3	Yes	No	1	2	1	1
L:L:K9	R:R:Q192	2.71	3	Yes	No	0	2	0	1
L:L:K9	R:R:E194	5.4	3	Yes	Yes	0	1	0	1
L:L:K13	R:R:E194	5.4	3	No	Yes	0	1	0	1
R:R:E199	R:R:L201	2.65	0	Yes	No	2	3	1	2
L:L:R8	R:R:E199	12.79	0	No	Yes	0	2	0	1
L:L:K9	R:R:E199	12.15	3	Yes	Yes	0	2	0	1
L:L:F4	R:R:C200	5.59	1	Yes	Yes	0	9	0	1
R:R:F215	R:R:I219	6.28	0	No	No	6	4	2	1
L:L:F1	R:R:I219	2.51	0	Yes	No	0	4	0	1
R:R:F220	R:R:Q280	7.03	0	No	Yes	5	7	2	1
R:R:Q280	R:R:S223	10.11	0	Yes	No	7	6	1	2
R:R:F224	R:R:Q280	5.86	0	Yes	Yes	8	7	2	1
L:L:F1	R:R:V279	2.62	0	Yes	No	0	6	0	1
L:L:F1	R:R:Q280	4.68	0	Yes	Yes	0	7	0	1
R:R:F282	R:R:Q286	7.03	0	No	No	5	4	2	1
L:L:F1	R:R:V283	7.87	0	Yes	No	0	5	0	1
R:R:P292	R:R:Q286	9.47	0	Yes	No	4	4	1	1
L:L:T5	R:R:Q286	5.67	0	No	No	0	4	0	1
L:L:S10	R:R:Q291	7.22	0	No	No	0	6	0	1
L:L:L14	R:R:S293	6.01	0	No	No	0	1	0	1
R:R:A297	R:R:P292	1.87	0	No	Yes	3	4	2	1
L:L:A7	R:R:P292	1.87	0	No	Yes	0	4	0	1
R:R:G308	R:R:V279	1.84	0	No	No	7	6	2	1
L:L:G2	R:R:V283	1.84	0	No	No	0	5	0	1
L:L:S10	R:R:P292	1.78	0	No	Yes	0	4	0	1
R:R:G189	R:R:I127	1.76	0	No	Yes	5	4	2	1
L:L:A11	R:R:V298	1.7	0	No	No	0	3	0	1
R:R:M134	R:R:T138	1.51	0	No	No	7	7	1	2
L:L:R8	R:R:G114	1.5	0	No	No	0	4	0	1
L:L:L14	R:R:Q291	1.33	0	No	No	0	6	0	1
R:R:R302	R:R:V298	1.31	0	No	No	4	3	2	1
R:R:D195	R:R:E194	1.3	0	No	Yes	1	1	2	1
L:L:R12	R:R:E199	1.16	0	No	Yes	0	2	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8F7X_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.39
Number of Linked Nodes	264
Number of Links	280
Number of Hubs	30
Number of Links mediated by Hubs	111
Number of Communities	7
Number of Nodes involved in Communities	30
Number of Links involved in Communities	35

Path Summary
Number Of Nodes in MetaPath	117
Number Of Links MetaPath	116
Number of Shortest Paths	39667
Length Of Smallest Path	3
Average Path Length	13.731
Length of Longest Path	31
Minimum Path Strength	1.4
Average Path Strength	4.95771
Maximum Path Strength	18.21
Minimum Path Correlation	0.7
Average Path Correlation	0.920257
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	46.2241
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.9711
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41146
Sequence	>8F7X_nogp_Chain_R G L K V T I V G L Y L A V C V G G L L G N C L V M Y V I L R H T K M K T A T N I Y I F N L A L A D T L V L L T L P F Q G T D I L L G F W P F G N A L C K T V I A I D Y Y N M F T S T F T L T A M S V D R Y V A I C H P I R A L D V R T S S K A Q A V N V A I W A L A S V V G V P V A I M G S A Q V E D E E I E C L V E I P T P Q D Y W G P V F A I C I F L F S F I V P V L V I S V C Y S L M I R R L R G V R L L S G S R E K D R N L R R I T R L V L V V V A V F V G C W T P V Q V F V L A Q G L G V Q P S S E T A V A I L R F C T A L G Y V N S C L N P I L Y A F L D E N F K A C F R K F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8F7X	A	Peptide	Opioid	NOP	Homo sapiens	Nociceptin	-	Gi1/β1/γ2	3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	8F7X (No Gprot)	A	Peptide	Opioid	NOP	Homo sapiens	Nociceptin	-		3.28	2022-12-14	doi.org/10.1016/j.cell.2022.12.026
	5DHG	A	Peptide	Opioid	NOP	Homo sapiens	C-35	-	-	3	2015-10-21	doi.org/10.1016/j.str.2015.07.024
	5DHH	A	Peptide	Opioid	NOP	Homo sapiens	SB-612111	-	-	3	2015-10-21	doi.org/10.1016/j.str.2015.07.024
	4EA3	A	Peptide	Opioid	NOP	Homo sapiens	PubChem 10296561	-	-	3.01	2012-04-25	doi.org/10.1038/nature11085

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