psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:N22	R:R:D107	5.39	No	No	5	0	4
2	L:L:N22	R:R:F195	7.25	No	Yes	5	0	1
3	L:L:L23	R:R:R103	6.07	No	Yes	0	0	5
4	L:L:L23	R:R:F195	4.87	No	Yes	0	0	1
5	L:L:W24	R:R:Y104	9.65	Yes	Yes	1	0	5
6	L:L:W24	R:R:H302	9.52	Yes	Yes	1	0	4
7	L:L:W24	R:R:M303	15.12	Yes	No	1	0	4
8	L:L:W24	R:R:T306	6.06	Yes	Yes	1	0	5
9	L:L:A25	R:R:I296	3.25	No	No	0	0	1
10	L:L:T26	R:R:R103	6.47	No	Yes	0	0	5
11	L:L:T26	R:R:A197	5.03	No	No	0	0	4
12	L:L:G27	R:R:R103	6	No	Yes	0	0	5
13	L:L:H28	R:R:P120	16.78	Yes	No	0	0	5
14	L:L:H28	R:R:E178	6.15	Yes	Yes	3	0	5
15	L:L:H28	R:R:S182	8.37	Yes	No	0	0	6
16	L:L:H28	R:R:C198	5.9	Yes	No	0	0	9
17	L:L:H28	R:R:P200	22.88	Yes	No	3	0	5
18	L:L:F29	R:R:I216	5.02	Yes	No	0	0	5
19	L:L:F29	R:R:N282	6.04	Yes	No	0	0	6
20	L:L:F29	R:R:H283	10.18	Yes	Yes	0	0	8
21	L:L:F29	R:R:Y286	9.28	Yes	No	0	0	5
22	L:L:M30	R:R:C96	9.73	Yes	Yes	4	0	7
23	L:L:M30	R:R:Q123	4.08	Yes	Yes	4	0	6
24	L:L:M30	R:R:F314	3.73	Yes	Yes	4	0	7
25	R:R:E39	R:R:L300	5.3	No	No	0	3	1
26	R:R:L40	R:R:R43	3.64	No	No	0	3	5
27	R:R:I46	R:R:P47	3.39	No	No	0	7	6
28	R:R:I46	R:R:L307	7.14	No	No	0	7	4
29	R:R:I54	R:R:Y50	12.09	No	Yes	4	6	8
30	R:R:V97	R:R:Y50	5.05	No	Yes	4	7	8
31	R:R:F314	R:R:Y50	8.25	Yes	Yes	4	7	8
32	R:R:I54	R:R:V97	9.22	No	No	4	6	7
33	R:R:F314	R:R:I54	3.77	Yes	No	4	7	6
34	R:R:C318	R:R:V56	5.12	No	Yes	0	8	6
35	R:R:F322	R:R:V56	3.93	No	Yes	0	7	6
36	R:R:L58	R:R:L93	5.54	No	No	0	7	7
37	R:R:G60	R:R:P321	4.06	No	No	0	8	9
38	R:R:D89	R:R:N61	5.39	No	No	0	9	9
39	R:R:L90	R:R:N61	5.49	No	No	0	8	9
40	R:R:L93	R:R:N61	4.12	No	No	0	7	9
41	R:R:F335	R:R:M63	8.71	Yes	No	0	7	6
42	R:R:A86	R:R:L64	4.73	No	No	0	9	9
43	R:R:F335	R:R:L64	3.65	Yes	No	0	7	9
44	R:R:K66	R:R:T70	9.01	Yes	No	0	3	6
45	R:R:K66	R:R:Q338	16.27	Yes	No	0	3	5
46	R:R:F331	R:R:I67	5.02	Yes	Yes	0	8	8
47	R:R:H334	R:R:I67	5.3	Yes	Yes	0	6	8
48	R:R:F335	R:R:I67	3.77	Yes	Yes	0	7	8
49	R:R:I67	R:R:Q338	8.23	Yes	No	0	8	5
50	R:R:F68	R:R:I82	5.02	Yes	No	0	7	8
51	R:R:F68	R:R:S83	11.89	Yes	No	0	7	6
52	R:R:F331	R:R:F68	4.29	Yes	Yes	2	8	7
53	R:R:A73	R:R:N71	4.69	No	No	0	5	5
54	R:R:M74	R:R:N71	4.21	Yes	No	2	7	5
55	R:R:H334	R:R:N71	7.65	Yes	No	2	6	5
56	R:R:R75	R:R:S72	7.91	No	No	0	7	5
57	R:R:M74	R:R:S330	6.13	Yes	No	2	7	7
58	R:R:F331	R:R:M74	6.22	Yes	Yes	2	8	7
59	R:R:H334	R:R:M74	13.13	Yes	Yes	2	6	7
60	R:R:P78	R:R:S76	5.34	No	No	2	8	8
61	R:R:N79	R:R:S76	8.94	Yes	No	2	8	8
62	R:R:P78	R:R:V77	3.53	No	Yes	0	8	7
63	R:R:L157	R:R:V77	4.47	No	Yes	0	2	7
64	R:R:T160	R:R:V77	4.76	No	Yes	0	8	7
65	R:R:N79	R:R:P78	4.89	Yes	No	2	8	8
66	R:R:F81	R:R:I80	5.02	Yes	No	0	7	5
67	R:R:I80	R:R:T160	6.08	No	No	0	5	8
68	R:R:A136	R:R:F81	4.16	No	Yes	7	7	7
69	R:R:D140	R:R:F81	7.17	No	Yes	0	8	7
70	R:R:F81	R:R:K163	8.69	Yes	No	7	7	6
71	R:R:N84	R:R:T133	10.24	No	No	0	9	8
72	R:R:N84	R:R:W168	14.69	No	No	0	9	9
73	R:R:L85	R:R:T133	5.9	Yes	No	0	9	8
74	R:R:L85	R:R:Q134	6.65	Yes	No	0	9	8
75	R:R:L85	R:R:N320	5.49	Yes	No	0	9	9
76	R:R:D89	R:R:S130	5.89	No	No	0	9	9
77	R:R:D89	R:R:S317	5.89	No	No	0	9	9
78	R:R:L90	R:R:L94	5.54	No	No	0	8	6
79	R:R:I122	R:R:L91	4.28	No	No	0	5	7
80	R:R:L91	R:R:S126	7.51	No	No	0	7	8
81	R:R:L92	R:R:S126	4.5	No	No	0	7	8
82	R:R:L93	R:R:S317	9.01	No	No	0	7	9
83	R:R:C96	R:R:T95	3.38	Yes	No	0	7	5
84	R:R:C96	R:R:Q123	10.68	Yes	Yes	4	7	6
85	R:R:P98	R:R:V97	3.53	No	No	0	9	7
86	R:R:R103	R:R:V99	5.23	Yes	No	0	5	6
87	R:R:Q123	R:R:V99	5.73	Yes	No	0	6	6
88	R:R:D100	R:R:R310	8.34	No	No	0	6	6
89	R:R:D100	R:R:F314	7.17	No	Yes	0	6	7
90	R:R:R103	R:R:W109	12	Yes	No	0	5	9
91	R:R:M303	R:R:Y104	3.59	No	Yes	1	4	5
92	R:R:T306	R:R:Y104	3.75	Yes	Yes	1	5	5
93	R:R:L307	R:R:Y104	4.69	No	Yes	1	4	5
94	R:R:R310	R:R:Y104	4.12	No	Yes	0	6	5
95	R:R:D107	R:R:F195	11.94	No	Yes	5	4	1
96	R:R:F111	R:R:W109	7.02	Yes	No	0	7	9
97	R:R:C198	R:R:W109	5.22	No	No	0	9	9
98	R:R:F111	R:R:I119	7.54	Yes	Yes	0	7	5
99	R:R:G115	R:R:I119	3.53	No	Yes	0	5	5
100	R:R:C116	R:R:V184	3.42	No	No	0	9	5
101	R:R:C116	R:R:C198	7.28	No	No	0	9	9
102	R:R:I119	R:R:P120	3.39	Yes	No	0	5	5
103	R:R:I119	R:R:Q123	4.12	Yes	Yes	0	5	6
104	R:R:A175	R:R:L124	4.73	No	No	0	7	5
105	R:R:E178	R:R:L124	5.3	Yes	No	0	5	5
106	R:R:L124	R:R:Y220	5.86	No	Yes	0	5	6
107	R:R:S171	R:R:T125	4.8	No	No	0	8	5
108	R:R:T125	R:R:V172	4.76	No	No	0	5	4
109	R:R:V129	R:R:W168	17.16	No	No	0	7	9
110	R:R:S171	R:R:V129	6.46	No	No	0	8	7
111	R:R:P224	R:R:V131	3.53	No	No	0	9	8
112	R:R:F132	R:R:I167	7.54	No	No	0	6	7
113	R:R:F132	R:R:V170	5.24	No	No	0	6	4
114	R:R:F275	R:R:Q134	4.68	Yes	No	0	9	8
115	R:R:N316	R:R:Q134	5.28	No	No	0	9	8
116	R:R:A136	R:R:K163	3.21	No	No	7	7	6
117	R:R:I228	R:R:S138	6.19	No	No	0	8	9
118	R:R:S138	R:R:Y231	5.09	No	Yes	0	9	7
119	R:R:S138	R:R:Y232	11.45	No	Yes	0	9	9
120	R:R:A139	R:R:Y231	5.34	No	Yes	0	6	7
121	R:R:F271	R:R:R141	3.21	Yes	No	0	8	9
122	R:R:V146	R:R:Y142	7.57	No	No	0	7	8
123	R:R:Y142	R:R:Y231	15.89	No	Yes	0	8	7
124	R:R:H234	R:R:Y142	8.71	No	No	0	4	8
125	R:R:I145	R:R:I235	7.36	No	No	0	8	8
126	R:R:N147	R:R:V146	4.43	No	No	0	7	7
127	R:R:T238	R:R:V146	6.35	No	No	0	5	7
128	R:R:L174	R:R:Y220	5.86	No	Yes	0	5	6
129	R:R:P177	R:R:V176	3.53	No	No	0	7	5
130	R:R:E178	R:R:P200	4.72	Yes	No	3	5	5
131	R:R:E178	R:R:H212	7.39	Yes	No	0	5	6
132	R:R:F181	R:R:H208	24.89	No	Yes	0	5	1
133	R:R:E183	R:R:I199	4.1	No	No	0	4	3
134	R:R:E183	R:R:P202	4.72	No	No	0	4	5
135	R:R:T196	R:R:V184	6.35	No	No	0	4	5
136	R:R:A185	R:R:I199	3.25	No	No	0	1	3
137	R:R:R186	R:R:S194	3.95	No	No	0	3	4
138	R:R:R186	R:R:T196	3.88	No	No	0	3	4
139	R:R:F195	R:R:I187	5.02	Yes	No	0	1	1
140	R:R:I187	R:R:I296	4.42	No	No	0	1	1
141	R:R:P200	R:R:Y201	11.13	No	Yes	3	5	5
142	R:R:H208	R:R:Y201	4.36	Yes	Yes	3	1	5
143	R:R:P209	R:R:Y201	16.69	No	Yes	3	4	5
144	R:R:H212	R:R:Y201	10.89	No	Yes	0	6	5
145	R:R:Y201	R:R:Y286	8.94	Yes	No	0	5	5
146	R:R:N294	R:R:Q203	5.28	Yes	No	0	1	4
147	R:R:E206	R:R:Y293	11.22	No	No	3	1	1
148	R:R:E206	R:R:N294	5.26	No	Yes	3	1	1
149	R:R:K210	R:R:L207	4.23	No	No	0	3	2
150	R:R:I211	R:R:L207	4.28	No	No	0	4	2
151	R:R:H208	R:R:P209	4.58	Yes	No	3	1	4
152	R:R:P209	R:R:Y293	9.74	No	No	3	4	1
153	R:R:F291	R:R:K210	6.2	No	No	0	5	3
154	R:R:H212	R:R:I216	11.93	No	No	0	6	5
155	R:R:M287	R:R:S213	4.6	No	No	0	6	5
156	R:R:S213	R:R:S290	6.52	No	No	0	5	5
157	R:R:I216	R:R:Y220	7.25	No	Yes	0	5	6
158	R:R:F217	R:R:F221	11.79	No	Yes	6	6	8
159	R:R:F217	R:R:H283	5.66	No	Yes	6	6	8
160	R:R:F217	R:R:M287	12.44	No	No	0	6	6
161	R:R:L218	R:R:L222	4.15	No	No	0	5	4
162	R:R:I223	R:R:L218	4.28	No	No	0	5	5
163	R:R:V219	R:R:Y220	5.05	No	Yes	0	5	6
164	R:R:F221	R:R:L225	3.65	Yes	No	0	8	7
165	R:R:F221	R:R:F280	5.36	Yes	No	0	8	6
166	R:R:F221	R:R:H283	19.23	Yes	Yes	6	8	8
167	R:R:I223	R:R:P224	3.39	No	No	0	5	9
168	R:R:F275	R:R:L225	7.31	Yes	No	0	9	7
169	R:R:I276	R:R:L225	7.14	No	No	0	6	7
170	R:R:I227	R:R:Y231	4.84	No	Yes	0	6	7
171	R:R:F275	R:R:I228	8.79	Yes	No	0	9	8
172	R:R:S229	R:R:V272	6.46	No	No	0	5	8
173	R:R:V268	R:R:Y232	3.79	No	Yes	0	8	9
174	R:R:F271	R:R:Y232	7.22	Yes	Yes	0	8	9
175	R:R:V272	R:R:Y232	5.05	No	Yes	0	8	9
176	R:R:I235	R:R:V268	4.61	No	No	0	8	8
177	R:R:A236	R:R:L269	4.73	No	No	0	5	5
178	R:R:L239	R:R:R261	7.29	No	Yes	0	8	7
179	R:R:L239	R:R:L264	4.15	No	No	0	8	8
180	R:R:A265	R:R:L239	4.73	No	No	0	6	8
181	R:R:I240	R:R:K262	8.72	No	No	0	5	5
182	R:R:R261	R:R:S242	6.59	Yes	No	0	7	6
183	R:R:A243	R:R:M258	4.83	No	No	0	4	3
184	R:R:A243	R:R:K262	3.21	No	No	0	4	5
185	R:R:H244	R:R:K262	14.41	No	No	0	2	5
186	R:R:E252	R:R:T254	9.88	No	No	0	3	3
187	R:R:E252	R:R:K255	4.05	No	No	0	3	4
188	R:R:H253	R:R:T254	6.85	No	No	0	4	3
189	R:R:M258	R:R:T254	7.53	No	No	0	3	3
190	R:R:Q257	R:R:R261	3.5	No	Yes	0	5	7
191	R:R:M258	R:R:R261	6.2	No	Yes	0	3	7
192	R:R:L264	R:R:L327	4.15	No	No	0	8	7
193	R:R:F271	R:R:I267	5.02	Yes	No	0	8	8
194	R:R:I267	R:R:L327	7.14	No	No	0	8	7
195	R:R:F275	R:R:W279	18.04	Yes	No	0	9	8
196	R:R:F277	R:R:L312	13.4	No	No	0	6	7
197	R:R:C278	R:R:N316	4.72	No	No	0	9	9
198	R:R:H283	R:R:W279	8.46	Yes	No	0	8	8
199	R:R:N316	R:R:W279	16.95	No	No	0	9	8
200	R:R:F280	R:R:P281	4.33	No	No	0	6	9
201	R:R:L312	R:R:P281	3.28	No	No	0	7	9
202	R:R:N282	R:R:S313	8.94	No	No	0	6	8
203	R:R:L285	R:R:R289	6.07	Yes	No	1	5	4
204	R:R:L285	R:R:T306	5.9	Yes	Yes	1	5	5
205	R:R:S290	R:R:Y286	5.09	No	No	0	5	5
206	R:R:N292	R:R:Y288	9.3	No	No	1	3	4
207	R:R:D297	R:R:Y288	3.45	Yes	No	1	1	4
208	R:R:H302	R:R:R289	7.9	Yes	No	1	4	4
209	R:R:R289	R:R:T306	5.17	No	Yes	1	4	5
210	R:R:D297	R:R:N292	5.39	Yes	No	1	1	3
211	R:R:N294	R:R:Y293	22.1	Yes	No	3	1	1
212	R:R:E295	R:R:N294	3.94	No	Yes	0	1	1
213	R:R:D297	R:R:H302	6.3	Yes	Yes	1	1	4
214	R:R:H302	R:R:T306	5.48	Yes	Yes	1	4	5
215	R:R:L307	R:R:M303	7.07	No	No	1	4	4
216	R:R:N320	R:R:P321	3.26	No	No	0	9	9
217	R:R:F331	R:R:L324	15.83	Yes	No	0	8	9
218	R:R:R332	R:R:Y325	8.23	No	No	8	9	7
219	R:R:F335	R:R:Y325	9.28	Yes	No	0	7	7
220	R:R:N336	R:R:Y325	8.14	No	No	8	4	7
221	R:R:L326	R:R:L327	4.15	No	No	0	6	7
222	R:R:S328	R:R:S330	3.26	No	No	2	8	7
223	R:R:F331	R:R:S328	3.96	Yes	No	2	8	8
224	R:R:E329	R:R:R332	5.82	No	No	0	5	9
225	R:R:F331	R:R:S330	3.96	Yes	No	2	8	7
226	R:R:N336	R:R:R332	3.62	No	No	8	4	9
227	R:R:H334	R:R:R333	4.51	Yes	No	0	6	5
228	R:R:C96	R:R:L92	3.17	Yes	No	0	7	7
229	R:R:C161	R:R:L157	3.17	No	No	0	3	2
230	R:R:A309	R:R:L285	3.15	No	Yes	0	7	5
231	L:L:T26	R:R:I199	3.04	No	No	0	0	3
232	L:L:M30	R:R:V127	3.04	Yes	No	0	0	7
233	R:R:I69	R:R:T70	3.04	No	No	0	3	6
234	R:R:L85	R:R:S130	3	Yes	No	0	9	9
235	R:R:L49	R:R:V45	2.98	No	No	0	4	5
236	R:R:L52	R:R:V56	2.98	No	Yes	0	5	6
237	R:R:L173	R:R:V169	2.98	No	No	0	5	4
238	R:R:L174	R:R:V170	2.98	No	No	0	5	4
239	R:R:L312	R:R:V311	2.98	No	No	0	7	5
240	R:R:I223	R:R:I227	2.94	No	No	0	5	6
241	R:R:I284	R:R:M287	2.92	No	No	0	7	6
242	R:R:G128	R:R:Y220	2.9	No	Yes	0	6	6
243	R:R:K113	R:R:K117	2.87	No	No	0	3	7
244	R:R:I122	R:R:L118	2.85	No	No	0	5	5
245	R:R:I211	R:R:L215	2.85	No	No	0	4	4
246	R:R:A164	R:R:F81	2.77	No	Yes	0	8	7
247	R:R:A101	R:R:F105	2.77	No	No	0	6	4
248	R:R:A323	R:R:F271	2.77	No	Yes	0	8	8
249	R:R:D205	R:R:H208	2.52	No	Yes	0	3	1
250	R:R:F81	R:R:L137	2.44	Yes	No	0	7	9
251	R:R:F68	R:R:N79	2.42	Yes	Yes	2	7	8
252	R:R:F331	R:R:N79	2.42	Yes	Yes	2	8	8
253	R:R:L51	R:R:Y50	2.34	No	Yes	0	5	8
254	R:R:H234	R:R:Y233	2.18	No	No	0	4	3
255	R:R:F105	R:R:F106	2.14	No	No	0	4	2
256	R:R:C318	R:R:G57	1.96	No	No	0	8	8
257	R:R:G57	R:R:S317	1.86	No	No	0	8	9
258	R:R:G88	R:R:S126	1.86	No	No	0	8	8
259	R:R:G301	R:R:S299	1.86	No	No	0	1	3
260	R:R:G115	R:R:V114	1.84	No	No	0	5	1
261	R:R:G166	R:R:V169	1.84	No	No	0	4	4
262	R:R:G273	R:R:V272	1.84	No	No	0	5	8
263	R:R:A236	R:R:A265	1.79	No	No	0	5	6
264	R:R:G315	R:R:I53	1.76	No	No	0	5	7
265	R:R:G301	R:R:I304	1.76	No	No	0	1	1
266	R:R:G60	R:R:M63	1.75	No	No	0	8	6
267	R:R:P224	R:R:T135	1.75	No	No	0	9	7
268	R:R:G166	R:R:M165	1.75	No	No	0	4	3
269	R:R:P202	R:R:T204	1.75	No	No	0	5	3
270	R:R:G342	R:R:K66	1.74	No	Yes	0	3	3
271	R:R:G60	R:R:L59	1.71	No	No	0	8	5
272	R:R:C274	R:R:V270	1.71	No	No	0	7	7
273	R:R:C278	R:R:V319	1.71	No	No	0	9	6
274	R:R:A156	R:R:V77	1.7	No	Yes	0	7	7
275	R:R:A175	R:R:V121	1.7	No	No	0	7	6
276	R:R:A179	R:R:V121	1.7	No	No	0	5	6
277	R:R:M149	R:R:P148	1.68	No	No	0	5	7
278	R:R:C318	R:R:I53	1.64	No	No	0	8	7
279	R:R:N147	R:R:P148	1.63	No	No	0	7	7
280	R:R:C341	R:R:K66	1.62	No	Yes	0	9	3
281	R:R:A179	R:R:K117	1.61	No	No	0	5	7
282	R:R:A144	R:R:M151	1.61	No	No	0	8	5
283	R:R:D297	R:R:P298	1.61	Yes	No	0	1	3
284	R:R:V41	R:R:V45	1.6	No	No	0	2	5
285	R:R:T55	R:R:V56	1.59	No	Yes	0	5	6
286	R:R:I296	R:R:S188	1.55	No	No	0	1	2
287	R:R:I62	R:R:V65	1.54	No	No	0	4	7
288	R:R:F111	R:R:G112	1.51	Yes	No	0	7	8
289	R:R:K237	R:R:T238	1.5	No	No	0	3	5
290	R:R:L215	R:R:V214	1.49	No	No	0	4	4
291	R:R:L285	R:R:V305	1.49	Yes	No	0	5	5
292	R:R:I240	R:R:K266	1.45	No	No	0	5	6
293	R:R:Q338	R:R:S337	1.44	No	No	0	5	4
294	R:R:C44	R:R:R43	1.39	No	No	0	5	5
295	R:R:H302	R:R:S299	1.39	Yes	No	0	4	3
296	R:R:L339	R:R:N336	1.37	No	No	0	7	4
297	R:R:D205	R:R:L207	1.36	No	No	0	3	2
298	R:R:D150	R:R:N147	1.35	No	No	0	4	7
299	R:R:R103	R:R:S102	1.32	Yes	No	0	5	4
300	R:R:F106	R:R:S102	1.32	No	No	0	2	4
301	R:R:F181	R:R:V180	1.31	No	No	0	5	4
302	R:R:D107	R:R:E108	1.3	No	No	0	4	4
303	R:R:H244	R:R:N245	1.28	No	No	0	2	2
304	R:R:I267	R:R:R263	1.25	No	No	0	8	7
305	R:R:F106	R:R:M110	1.24	No	No	0	2	3
306	R:R:F111	R:R:M110	1.24	Yes	No	0	7	3
307	R:R:I230	R:R:Y231	1.21	No	Yes	0	4	7
308	R:R:D150	R:R:R143	1.19	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:W24	10.0875	4	1	0
2	L:L:H28	12.016	5	3	0
3	L:L:F29	7.63	4	0	0
4	L:L:M30	5.145	4	4	0
5	R:R:Y50	6.9325	4	4	8
6	R:R:V56	3.405	4	0	6
7	R:R:K66	7.16	4	0	3
8	R:R:I67	5.58	4	0	8
9	R:R:F68	5.905	4	2	7
10	R:R:M74	7.4225	4	2	7
11	R:R:V77	3.615	4	0	7
12	R:R:N79	4.6675	4	2	8
13	R:R:F81	5.04167	6	7	7
14	R:R:L85	5.26	4	0	9
15	R:R:C96	6.74	4	4	7
16	R:R:R103	6.18167	6	0	5
17	R:R:Y104	5.16	5	1	5
18	R:R:F111	4.3275	4	0	7
19	R:R:I119	4.645	4	0	5
20	R:R:Q123	6.1525	4	4	6
21	R:R:E178	5.89	4	3	5
22	R:R:F195	7.27	4	5	1
23	R:R:Y201	10.402	5	3	5
24	R:R:H208	9.0875	4	3	1
25	R:R:Y220	5.384	5	0	6
26	R:R:F221	10.0075	4	6	8
27	R:R:Y231	6.474	5	0	7
28	R:R:Y232	6.8775	4	0	9
29	R:R:R261	5.895	4	0	7
30	R:R:F271	4.555	4	0	8
31	R:R:F275	9.705	4	0	9
32	R:R:H283	10.8825	4	6	8
33	R:R:L285	4.1525	4	1	5
34	R:R:N294	9.145	4	3	1
35	R:R:D297	4.1875	4	1	1
36	R:R:H302	6.118	5	1	4
37	R:R:T306	5.272	5	1	5
38	R:R:F314	5.73	4	4	7
39	R:R:F331	5.95714	7	2	8
40	R:R:H334	7.6475	4	2	6
41	R:R:F335	6.3525	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:M30	R:R:Q123	40.9509	4.08	Yes	Yes	4	0	6
2	L:L:M30	R:R:F314	39.5556	3.73	Yes	Yes	4	0	7
3	R:R:D100	R:R:F314	31.4132	7.17	No	Yes	0	6	7
4	R:R:D100	R:R:R310	30.4361	8.34	No	No	0	6	6
5	R:R:R310	R:R:Y104	29.3935	4.12	No	Yes	0	6	5
6	R:R:T306	R:R:Y104	14.2651	3.75	Yes	Yes	1	5	5
7	L:L:H28	R:R:C198	34.8108	5.9	Yes	No	0	0	9
8	R:R:C198	R:R:W109	30.0102	5.22	No	No	0	9	9
9	R:R:R103	R:R:W109	23.0839	12	Yes	No	0	5	9
10	R:R:I119	R:R:Q123	48.6943	4.12	Yes	Yes	0	5	6
11	R:R:I119	R:R:P120	55.7363	3.39	Yes	No	0	5	5
12	L:L:H28	R:R:P120	56.5476	16.78	Yes	No	0	0	5
13	L:L:H28	R:R:E178	45.1425	6.15	Yes	Yes	3	0	5
14	L:L:H28	R:R:P200	46.4761	22.88	Yes	No	3	0	5
15	L:L:F29	R:R:I216	49.2416	5.02	Yes	No	0	0	5
16	R:R:H212	R:R:I216	43.5063	11.93	No	No	0	6	5
17	R:R:E178	R:R:H212	43.2616	7.39	Yes	No	0	5	6
18	L:L:F29	R:R:Y286	50.953	9.28	Yes	No	0	0	5
19	R:R:Y201	R:R:Y286	51.192	8.94	Yes	No	0	5	5
20	R:R:P200	R:R:Y201	47.0427	11.13	No	Yes	3	5	5
21	L:L:F29	R:R:H283	100	10.18	Yes	Yes	0	0	8
22	R:R:H283	R:R:W279	97.5371	8.46	Yes	No	0	8	8
23	R:R:F275	R:R:W279	61.4678	18.04	Yes	No	0	9	8
24	R:R:F275	R:R:Q134	45.3719	4.68	Yes	No	0	9	8
25	R:R:L85	R:R:Q134	79.4908	6.65	Yes	No	0	9	8
26	R:R:L85	R:R:S130	21.0892	3	Yes	No	0	9	9
27	R:R:D89	R:R:S130	19.9503	5.89	No	No	0	9	9
28	R:R:D89	R:R:S317	12.9816	5.89	No	No	0	9	9
29	R:R:N316	R:R:W279	36.6918	16.95	No	No	0	9	8
30	R:R:N316	R:R:Q134	35.7147	5.28	No	No	0	9	8
31	R:R:L85	R:R:N320	54.3371	5.49	Yes	No	0	9	9
32	R:R:N320	R:R:P321	53.3177	3.26	No	No	0	9	9
33	R:R:G60	R:R:P321	52.2943	4.06	No	No	0	8	9
34	R:R:G60	R:R:M63	50.2361	1.75	No	No	0	8	6
35	R:R:F335	R:R:M63	49.1973	8.71	Yes	No	0	7	6
36	R:R:F335	R:R:I67	40.8083	3.77	Yes	Yes	0	7	8
37	R:R:F331	R:R:I67	26.4468	5.02	Yes	Yes	0	8	8
38	R:R:F331	R:R:N79	17.4738	2.42	Yes	Yes	2	8	8
39	R:R:N79	R:R:P78	15.2691	4.89	Yes	No	2	8	8
40	R:R:P78	R:R:V77	14.134	3.53	No	Yes	0	8	7
41	R:R:F275	R:R:I228	35.9383	8.79	Yes	No	0	9	8
42	R:R:I228	R:R:S138	35.4006	6.19	No	No	0	8	9
43	R:R:S138	R:R:Y231	14.9068	5.09	No	Yes	0	9	7
44	R:R:S138	R:R:Y232	22.6098	11.45	No	Yes	0	9	9
45	R:R:F271	R:R:Y232	18.1599	7.22	Yes	Yes	0	8	9
46	R:R:F271	R:R:I267	16.2192	5.02	Yes	No	0	8	8
47	R:R:I267	R:R:L327	14.8837	7.14	No	No	0	8	7
48	R:R:L264	R:R:L327	13.5559	4.15	No	No	0	8	7
49	R:R:L239	R:R:L264	12.8736	4.15	No	No	0	8	8
50	R:R:L239	R:R:R261	10.1351	7.29	No	Yes	0	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:N22	R:R:D107	5.39	5	No	No	0	4	0	1
L:L:N22	R:R:F195	7.25	5	No	Yes	0	1	0	1
L:L:L23	R:R:R103	6.07	0	No	Yes	0	5	0	1
L:L:L23	R:R:F195	4.87	0	No	Yes	0	1	0	1
L:L:W24	R:R:Y104	9.65	1	Yes	Yes	0	5	0	1
L:L:W24	R:R:H302	9.52	1	Yes	Yes	0	4	0	1
L:L:W24	R:R:M303	15.12	1	Yes	No	0	4	0	1
L:L:W24	R:R:T306	6.06	1	Yes	Yes	0	5	0	1
L:L:A25	R:R:I296	3.25	0	No	No	0	1	0	1
L:L:T26	R:R:R103	6.47	0	No	Yes	0	5	0	1
L:L:T26	R:R:A197	5.03	0	No	No	0	4	0	1
L:L:G27	R:R:R103	6	0	No	Yes	0	5	0	1
L:L:H28	R:R:P120	16.78	3	Yes	No	0	5	0	1
L:L:H28	R:R:E178	6.15	3	Yes	Yes	0	5	0	1
L:L:H28	R:R:S182	8.37	3	Yes	No	0	6	0	1
L:L:H28	R:R:C198	5.9	3	Yes	No	0	9	0	1
L:L:H28	R:R:P200	22.88	3	Yes	No	0	5	0	1
L:L:F29	R:R:I216	5.02	0	Yes	No	0	5	0	1
L:L:F29	R:R:N282	6.04	0	Yes	No	0	6	0	1
L:L:F29	R:R:H283	10.18	0	Yes	Yes	0	8	0	1
L:L:F29	R:R:Y286	9.28	0	Yes	No	0	5	0	1
L:L:M30	R:R:C96	9.73	4	Yes	Yes	0	7	0	1
L:L:M30	R:R:Q123	4.08	4	Yes	Yes	0	6	0	1
L:L:M30	R:R:F314	3.73	4	Yes	Yes	0	7	0	1
R:R:I54	R:R:Y50	12.09	4	No	Yes	6	8	2	2
R:R:F314	R:R:Y50	8.25	4	Yes	Yes	7	8	1	2
R:R:F314	R:R:I54	3.77	4	Yes	No	7	6	1	2
R:R:C96	R:R:T95	3.38	4	Yes	No	7	5	1	2
R:R:C96	R:R:Q123	10.68	4	Yes	Yes	7	6	1	1
R:R:R103	R:R:V99	5.23	0	Yes	No	5	6	1	2
R:R:Q123	R:R:V99	5.73	4	Yes	No	6	6	1	2
R:R:D100	R:R:R310	8.34	0	No	No	6	6	2	2
R:R:D100	R:R:F314	7.17	0	No	Yes	6	7	2	1
R:R:R103	R:R:W109	12	0	Yes	No	5	9	1	2
R:R:M303	R:R:Y104	3.59	1	No	Yes	4	5	1	1
R:R:T306	R:R:Y104	3.75	1	Yes	Yes	5	5	1	1
R:R:L307	R:R:Y104	4.69	1	No	Yes	4	5	2	1
R:R:R310	R:R:Y104	4.12	0	No	Yes	6	5	2	1
R:R:D107	R:R:F195	11.94	5	No	Yes	4	1	1	1
R:R:C198	R:R:W109	5.22	0	No	No	9	9	1	2
R:R:C116	R:R:C198	7.28	0	No	No	9	9	2	1
R:R:I119	R:R:P120	3.39	0	Yes	No	5	5	2	1
R:R:I119	R:R:Q123	4.12	0	Yes	Yes	5	6	2	1
R:R:E178	R:R:L124	5.3	3	Yes	No	5	5	1	2
R:R:L124	R:R:Y220	5.86	0	No	Yes	5	6	2	2
R:R:E178	R:R:P200	4.72	3	Yes	No	5	5	1	1
R:R:E178	R:R:H212	7.39	3	Yes	No	5	6	1	2
R:R:E183	R:R:I199	4.1	0	No	No	4	3	2	1
R:R:A185	R:R:I199	3.25	0	No	No	1	3	2	1
R:R:F195	R:R:I187	5.02	5	Yes	No	1	1	1	2
R:R:I187	R:R:I296	4.42	0	No	No	1	1	2	1
R:R:P200	R:R:Y201	11.13	3	No	Yes	5	5	1	2
R:R:H212	R:R:Y201	10.89	0	No	Yes	6	5	2	2
R:R:Y201	R:R:Y286	8.94	3	Yes	No	5	5	2	1
R:R:H212	R:R:I216	11.93	0	No	No	6	5	2	1
R:R:I216	R:R:Y220	7.25	0	No	Yes	5	6	1	2
R:R:F217	R:R:F221	11.79	6	No	Yes	6	8	2	2
R:R:F217	R:R:H283	5.66	6	No	Yes	6	8	2	1
R:R:F221	R:R:H283	19.23	6	Yes	Yes	8	8	2	1
R:R:H283	R:R:W279	8.46	6	Yes	No	8	8	1	2
R:R:N282	R:R:S313	8.94	0	No	No	6	8	1	2
R:R:L285	R:R:R289	6.07	1	Yes	No	5	4	2	2
R:R:L285	R:R:T306	5.9	1	Yes	Yes	5	5	2	1
R:R:S290	R:R:Y286	5.09	0	No	No	5	5	2	1
R:R:H302	R:R:R289	7.9	1	Yes	No	4	4	1	2
R:R:R289	R:R:T306	5.17	1	No	Yes	4	5	2	1
R:R:D297	R:R:H302	6.3	1	Yes	Yes	1	4	2	1
R:R:H302	R:R:T306	5.48	1	Yes	Yes	4	5	1	1
R:R:L307	R:R:M303	7.07	1	No	No	4	4	2	1
R:R:C96	R:R:L92	3.17	4	Yes	No	7	7	1	2
L:L:T26	R:R:I199	3.04	0	No	No	0	3	0	1
L:L:M30	R:R:V127	3.04	4	Yes	No	0	7	0	1
R:R:I296	R:R:S188	1.55	0	No	No	1	2	1	2
R:R:H302	R:R:S299	1.39	1	Yes	No	4	3	1	2
R:R:R103	R:R:S102	1.32	0	Yes	No	5	4	1	2
R:R:D107	R:R:E108	1.3	5	No	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8H0P_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.21
Number of Linked Nodes	285
Number of Links	308
Number of Hubs	41
Number of Links mediated by Hubs	151
Number of Communities	8
Number of Nodes involved in Communities	49
Number of Links involved in Communities	63

Path Summary
Number Of Nodes in MetaPath	51
Number Of Links MetaPath	50
Number of Shortest Paths	73789
Length Of Smallest Path	3
Average Path Length	18.7042
Length of Longest Path	37
Minimum Path Strength	1.24
Average Path Strength	7.23789
Maximum Path Strength	19.83
Minimum Path Correlation	0.7
Average Path Correlation	0.935611
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.94118
Average % Of Corr. Nodes	41.9821
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.4232
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• hormone activity • protein binding • binding • molecular function activator activity • signaling receptor binding • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • bombesin receptor binding • neuromedin B receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • neuropeptide activity • neuropeptide hormone activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • organic anion transport • carboxylic acid transport • secretion
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • organic anion transport • carboxylic acid transport • secretion • transport • arachidonate transport • lipid localization • lipid transport • establishment of localization • organic acid transport • localization • arachidonate secretion • monocarboxylic acid transport • fatty acid transport • icosanoid transport • macromolecule localization • icosanoid secretion • long-chain fatty acid transport • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • positive regulation of testosterone secretion • positive regulation of cell communication • regulation of localization • regulation of hormone secretion • positive regulation of biological process • regulation of lipid transport • organic hydroxy compound transport • positive regulation of secretion by cell • hormone secretion • secretion by cell • positive regulation of hormone secretion • regulation of secretion by cell • positive regulation of secretion • signal release • positive regulation of cellular process • regulation of signaling • regulation of transport • regulation of hormone levels • cell-cell signaling • export from cell • positive regulation of lipid localization • regulation of secretion • testosterone secretion • positive regulation of lipid transport • positive regulation of transport • regulation of lipid localization • lipid export from cell • regulation of testosterone secretion • hormone transport • regulation of cell communication • positive regulation of signaling • sneeze reflex • reflex • response to external stimulus • biological process involved in interspecies interaction between organisms • immune response • response to other organism • defense response • defense response to symbiont • response to biotic stimulus • defense response to virus • immune system process • defense response to other organism • response to stress • innate immune response • antiviral innate immune response • response to external biotic stimulus • response to virus • interleukin-6 production • multicellular organismal process • negative regulation of biological process • regulation of interleukin-6 production • regulation of cytokine production • cytokine production • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • negative regulation of metabolic process • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • negative regulation of interleukin-6 production • negative regulation of gene expression • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • positive regulation of respiratory gaseous exchange • regulation of respiratory gaseous exchange • positive regulation of multicellular organismal process • respiratory gaseous exchange by respiratory system • regulation of leukocyte proliferation • cell population proliferation • positive regulation of cell population proliferation • osteoclast proliferation • regulation of osteoclast proliferation • positive regulation of osteoclast proliferation • leukocyte proliferation • regulation of cell population proliferation • positive regulation of leukocyte proliferation • negative regulation of signaling • negative regulation of transport • negative regulation of cell communication • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • interferon-alpha production • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of interferon-alpha production • positive regulation of type I interferon production • type I interferon production • positive regulation of interferon-alpha production • positive regulation of gene expression • positive regulation of cytokine production • regulation of type I interferon production • system process • sensory perception • nervous system process • sensory perception of itch • Leydig cell proliferation • cellular anatomical structure • extracellular region • extracellular space • cell projection • neuron projection • plasma membrane bounded cell projection • peptide receptor activity • molecular transducer activity • bombesin receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • phospholipase C-activating G protein-coupled receptor signaling pathway • intracellular anatomical structure • cytoplasm • cytosol • cell periphery • plasma membrane • membrane • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • developmental process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception of smell • cellular response to nitrogen compound • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • establishment of protein localization • nitrogen compound transport • regulation of protein localization • regulation of peptide secretion • protein localization to extracellular region • peptide secretion • amide transport • intracellular protein localization • regulation of peptide hormone secretion • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • regulation of protein transport • protein secretion • regulation of protein secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of peptide secretion • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • organelle • vesicle • extracellular membrane-bounded organelle • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • cilium • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P28336
Sequence	>8H0P_nogp_Chain_R E L V I R C V I P S L Y L L I I T V G L L G N I M L V K I F I T N S A M R S V P N I F I S N L A A G D L L L L L T C V P V D A S R Y F F D E W M F G K V G C K L I P V I Q L T S V G V S V F T Q T A L S A D R Y R A I V N P M D M G A L L R T C V K A M G I W V V S V L L A V P E A V F S E V A R I S S S F T A C I P Y P Q T D E L H P K I H S V L I F L V Y F L I P L A I I S I Y Y Y H I A K T L I K S A H N E H T K K Q M E T R K R L A K I V L V F V G C F I F C W F P N H I L Y M Y R S F N Y N E I D P S L G H M I V T L V A R V L S F G N S C V N P F A L Y L L S E S F R R H F N S Q L C C G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8H0P	A	Peptide	Bombesin	BB₁	Homo sapiens	NMB30	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.15	2023-08-09	doi.org/10.1038/s41422-022-00743-6
	8H0P (No Gprot)	A	Peptide	Bombesin	BB₁	Homo sapiens	NMB30	-		3.15	2023-08-09	doi.org/10.1038/s41422-022-00743-6
	9JF4	A	Peptide	Bombesin	BB₁	Homo sapiens	PD168368	-	-	3.6	2025-07-09	To be published

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