psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E4	R:R:T5	5.64	No	No	0	3	3
2	R:R:D7	R:R:E4	5.2	No	No	0	6	3
3	R:R:K269	R:R:Q6	6.78	No	No	0	2	6
4	R:R:Q6	R:R:W270	7.67	No	No	0	6	2
5	R:R:E14	R:R:Y10	14.59	Yes	Yes	1	6	6
6	R:R:S68	R:R:Y10	6.36	No	Yes	0	4	6
7	R:R:N273	R:R:Y10	18.61	No	Yes	0	4	6
8	R:R:I276	R:R:Y10	12.09	Yes	Yes	1	5	6
9	R:R:L277	R:R:Y10	5.86	No	Yes	1	4	6
10	R:R:I65	R:R:V11	9.22	No	No	0	7	7
11	R:R:L13	R:R:L277	4.15	No	No	0	4	4
12	R:R:E14	R:R:I61	8.2	Yes	Yes	1	6	6
13	R:R:E14	R:R:I276	5.47	Yes	Yes	1	6	5
14	R:R:E14	R:R:L277	6.63	Yes	No	1	6	4
15	R:R:E14	R:R:H280	14.77	Yes	Yes	1	6	7
16	R:R:A18	R:R:I61	6.5	No	Yes	0	6	6
17	R:R:N25	R:R:S21	4.47	Yes	No	0	9	8
18	R:R:S21	R:R:S283	6.52	No	No	0	8	9
19	R:R:S21	R:R:V284	6.46	No	Yes	0	8	6
20	R:R:A50	R:R:N25	4.69	No	Yes	0	9	9
21	R:R:D53	R:R:N25	13.46	Yes	Yes	0	9	9
22	R:R:N25	R:R:P287	9.77	Yes	No	0	9	9
23	R:R:A291	R:R:V28	5.09	No	No	0	8	9
24	R:R:V28	R:R:Y292	5.05	No	Yes	0	9	6
25	R:R:A31	R:R:F301	4.16	No	No	0	7	6
26	R:R:A35	R:R:L38	4.73	No	Yes	2	6	8
27	R:R:A35	R:R:T300	5.03	No	No	2	6	7
28	R:R:N36	R:R:Q39	6.6	No	No	0	6	8
29	R:R:L38	R:R:N43	4.12	Yes	Yes	2	8	9
30	R:R:D296	R:R:L38	5.43	No	Yes	2	7	8
31	R:R:F297	R:R:L38	7.31	Yes	Yes	2	8	8
32	R:R:L38	R:R:T300	7.37	Yes	No	2	8	7
33	R:R:P41	R:R:T40	5.25	No	No	0	6	8
34	R:R:T40	R:R:T42	6.28	No	Yes	2	8	9
35	R:R:N43	R:R:T40	5.85	Yes	No	2	9	8
36	R:R:N43	R:R:T42	4.39	Yes	Yes	2	9	9
37	R:R:D102	R:R:T42	7.23	Yes	Yes	2	9	9
38	R:R:T42	R:R:Y113	3.75	Yes	Yes	2	9	6
39	R:R:L46	R:R:N43	4.12	No	Yes	0	8	9
40	R:R:D296	R:R:N43	4.04	No	Yes	2	7	9
41	R:R:F297	R:R:N43	9.67	Yes	Yes	2	8	9
42	R:R:A98	R:R:F45	4.16	No	Yes	0	6	8
43	R:R:D102	R:R:F45	9.55	Yes	Yes	0	9	8
44	R:R:A122	R:R:F45	4.16	No	Yes	0	7	8
45	R:R:F45	R:R:I126	3.77	Yes	No	0	8	7
46	R:R:S48	R:R:S95	6.52	No	No	0	9	7
47	R:R:I126	R:R:S48	6.19	No	No	0	7	9
48	R:R:S48	R:R:W130	4.94	No	Yes	0	9	9
49	R:R:D53	R:R:L49	6.79	Yes	No	1	9	9
50	R:R:L49	R:R:S95	6.01	No	No	0	9	7
51	R:R:L49	R:R:N286	12.36	No	Yes	1	9	9
52	R:R:D53	R:R:S283	7.36	Yes	No	0	9	9
53	R:R:D53	R:R:N286	6.73	Yes	Yes	1	9	9
54	R:R:G57	R:R:V56	3.68	No	No	0	7	6
55	R:R:A60	R:R:V56	5.09	No	No	0	6	6
56	R:R:G57	R:R:I61	5.29	No	Yes	0	7	6
57	R:R:F59	R:R:L58	4.87	No	No	0	5	6
58	R:R:A60	R:R:V85	5.09	No	No	0	6	5
59	R:R:H280	R:R:I61	10.61	Yes	Yes	1	7	6
60	R:R:F63	R:R:L81	18.27	No	No	0	5	6
61	R:R:F63	R:R:F84	4.29	No	No	0	5	4
62	R:R:C78	R:R:I67	4.91	No	No	1	9	4
63	R:R:C171	R:R:I67	4.91	No	No	1	9	4
64	L:L:?1	R:R:I67	8.58	Yes	No	1	0	4
65	L:L:?1	R:R:S68	11.28	Yes	No	0	0	4
66	R:R:F71	R:R:L69	12.18	No	No	0	6	4
67	R:R:C72	R:R:K170	4.85	No	No	0	3	5
68	R:R:F75	R:R:N145	4.83	Yes	No	0	2	5
69	R:R:F75	R:R:K147	14.89	Yes	No	0	2	3
70	R:R:F75	R:R:V169	7.87	Yes	No	0	2	4
71	R:R:F75	R:R:V176	5.24	Yes	No	0	2	1
72	R:R:F141	R:R:Y76	4.13	Yes	No	0	5	1
73	R:R:C171	R:R:C78	7.28	No	No	1	9	9
74	R:R:C78	R:R:V176	5.12	No	No	0	9	1
75	R:R:L79	R:R:N145	5.49	No	No	0	6	5
76	R:R:L79	R:R:V176	5.96	No	No	0	6	1
77	R:R:F80	R:R:F84	5.36	No	No	0	4	4
78	R:R:F141	R:R:F80	5.36	Yes	No	0	5	4
79	R:R:C83	R:R:P140	5.65	No	No	0	6	4
80	R:R:C83	R:R:F141	4.19	No	Yes	0	6	5
81	R:R:F84	R:R:L88	3.65	No	No	0	4	6
82	R:R:F173	R:R:L86	6.09	Yes	No	1	4	3
83	R:R:L86	R:R:Y181	4.69	No	Yes	1	3	6
84	R:R:L86	R:R:M182	8.48	No	Yes	1	3	4
85	R:R:F134	R:R:V87	10.49	No	No	0	3	5
86	L:L:?1	R:R:T89	6.64	Yes	No	0	0	6
87	R:R:I93	R:R:Q90	4.12	No	Yes	0	7	5
88	R:R:F94	R:R:Q90	14.05	No	Yes	0	5	5
89	R:R:C190	R:R:Q90	6.1	No	Yes	0	6	5
90	R:R:S91	R:R:W130	14.83	No	Yes	0	7	9
91	R:R:I93	R:R:W247	10.57	No	Yes	0	7	7
92	R:R:F94	R:R:L129	4.87	No	No	0	5	6
93	R:R:L96	R:R:Y290	11.72	No	Yes	0	9	9
94	R:R:L97	R:R:P194	8.21	No	No	0	7	8
95	R:R:V99	R:R:Y290	5.05	No	Yes	0	9	9
96	R:R:A100	R:R:M198	4.83	No	No	0	9	8
97	R:R:D102	R:R:Y113	8.05	Yes	Yes	2	9	6
98	R:R:D102	R:R:V117	4.38	Yes	No	2	9	7
99	R:R:R103	R:R:Y202	5.14	No	Yes	0	9	9
100	R:R:R103	R:R:Y290	10.29	No	Yes	0	9	9
101	R:R:C108	R:R:Y104	12.1	No	No	0	7	8
102	R:R:I201	R:R:Y104	15.71	No	No	0	7	8
103	R:R:K204	R:R:Y104	9.55	No	No	0	4	8
104	R:R:A106	R:R:Y113	5.34	No	Yes	0	8	6
105	R:R:I107	R:R:I205	10.3	No	No	0	8	9
106	R:R:R112	R:R:V109	5.23	No	No	0	5	5
107	R:R:K114	R:R:Y113	7.17	No	Yes	0	4	6
108	R:R:V117	R:R:Y113	12.62	No	Yes	2	7	6
109	R:R:R121	R:R:T118	5.17	No	No	0	5	7
110	R:R:L129	R:R:W130	4.56	No	Yes	0	6	9
111	R:R:F185	R:R:I136	5.02	No	Yes	0	3	4
112	R:R:C190	R:R:I136	4.91	No	Yes	0	6	4
113	R:R:T139	R:R:Y181	8.74	No	Yes	0	6	6
114	R:R:P140	R:R:Y181	18.08	No	Yes	0	4	6
115	R:R:W144	R:R:Y181	13.5	No	Yes	1	5	6
116	R:R:F185	R:R:W144	7.02	No	No	1	3	5
117	R:R:P178	R:R:S146	7.13	No	No	0	4	4
118	R:R:L172	R:R:N175	9.61	No	No	0	4	5
119	R:R:F173	R:R:V177	17.04	Yes	No	0	4	3
120	R:R:F173	R:R:M182	7.46	Yes	Yes	1	4	4
121	L:L:?1	R:R:F173	33.86	Yes	Yes	1	0	4
122	R:R:E174	R:R:M179	4.06	No	No	0	5	3
123	R:R:M179	R:R:N254	5.61	No	No	1	3	5
124	L:L:?1	R:R:M179	4.25	Yes	No	1	0	3
125	R:R:S180	R:R:Y184	3.82	No	No	0	4	3
126	R:R:F185	R:R:Y181	11.35	No	Yes	1	3	6
127	R:R:M182	R:R:N186	7.01	Yes	No	1	4	5
128	L:L:?1	R:R:M182	9.56	Yes	Yes	1	0	4
129	R:R:F188	R:R:V183	3.93	Yes	No	1	5	5
130	R:R:F259	R:R:V183	3.93	Yes	No	1	4	5
131	R:R:F188	R:R:Y184	4.13	Yes	No	1	5	3
132	R:R:F259	R:R:Y184	6.19	Yes	No	1	4	3
133	R:R:H251	R:R:N186	5.1	Yes	No	1	7	5
134	L:L:?1	R:R:N186	10.32	Yes	No	1	0	5
135	R:R:F187	R:R:F188	8.57	Yes	Yes	1	6	5
136	R:R:F187	R:R:V191	6.55	Yes	No	1	6	7
137	R:R:F187	R:R:L192	9.74	Yes	No	1	6	4
138	R:R:F187	R:R:H251	22.63	Yes	Yes	1	6	7
139	R:R:F188	R:R:L192	3.65	Yes	No	1	5	4
140	R:R:F188	R:R:F259	4.29	Yes	Yes	1	5	4
141	R:R:H251	R:R:V191	11.07	Yes	No	1	7	7
142	R:R:P193	R:R:P194	7.79	No	No	0	4	8
143	R:R:F243	R:R:L195	4.87	No	No	0	9	7
144	R:R:M198	R:R:Y202	7.18	No	Yes	0	8	9
145	R:R:K204	R:R:V200	4.55	No	No	0	4	4
146	R:R:I239	R:R:Y202	12.09	No	Yes	0	8	9
147	R:R:V240	R:R:Y202	5.05	No	Yes	0	8	9
148	R:R:I205	R:R:L236	4.28	No	No	0	9	8
149	R:R:C210	R:R:F206	5.59	No	No	0	5	5
150	R:R:A233	R:R:F206	4.16	No	No	0	7	5
151	R:R:F206	R:R:L236	3.65	No	No	0	5	8
152	R:R:C210	R:R:E229	6.08	No	No	0	5	7
153	R:R:L213	R:R:R228	8.5	No	No	0	4	5
154	R:R:Q227	R:R:T224	5.67	No	No	0	5	4
155	R:R:E229	R:R:T225	7.06	No	No	0	7	5
156	R:R:E229	R:R:L226	5.3	No	No	0	7	4
157	R:R:H231	R:R:S235	4.18	No	No	0	8	8
158	R:R:R293	R:R:S235	3.95	No	No	0	7	8
159	R:R:M238	R:R:R293	4.96	No	No	0	7	7
160	R:R:I239	R:R:Y290	4.84	No	Yes	0	8	9
161	R:R:I242	R:R:V285	4.61	No	No	0	7	6
162	R:R:F243	R:R:W247	15.03	No	Yes	0	9	7
163	R:R:C246	R:R:W247	3.92	No	Yes	1	8	7
164	R:R:C246	R:R:N282	7.87	No	No	1	8	8
165	R:R:S279	R:R:W247	7.41	No	Yes	0	7	7
166	R:R:N282	R:R:W247	13.56	No	Yes	1	8	7
167	L:L:?1	R:R:W247	5.13	Yes	Yes	1	0	7
168	R:R:N254	R:R:V250	4.43	No	No	0	5	5
169	L:L:?1	R:R:H251	5.8	Yes	Yes	1	0	7
170	L:L:?1	R:R:N254	6.19	Yes	No	1	0	5
171	R:R:C255	R:R:F259	4.19	No	Yes	0	5	4
172	R:R:Q260	R:R:V256	8.6	No	No	0	4	3
173	R:R:F259	R:R:L258	3.65	Yes	No	0	4	4
174	R:R:M274	R:R:W270	4.65	No	No	0	3	2
175	L:L:?1	R:R:M272	4.25	Yes	No	0	0	4
176	R:R:H280	R:R:I276	3.98	Yes	Yes	1	7	5
177	L:L:?1	R:R:I276	4.29	Yes	Yes	1	0	5
178	R:R:N282	R:R:N286	12.26	No	Yes	1	8	9
179	R:R:N286	R:R:Y290	5.81	Yes	Yes	0	9	9
180	R:R:I288	R:R:Y292	4.84	No	Yes	0	6	6
181	R:R:R293	R:R:V289	3.92	No	No	0	7	8
182	R:R:A291	R:R:F297	4.16	No	Yes	0	8	8
183	R:R:F301	R:R:Y292	5.16	No	Yes	0	6	6
184	R:R:F297	R:R:N294	10.87	Yes	No	0	8	9
185	R:R:D296	R:R:F297	9.55	No	Yes	2	7	8
186	R:R:R307	R:R:Y308	17.49	No	No	0	5	1
187	R:R:G119	R:R:T118	3.64	No	No	0	2	7
188	R:R:G137	R:R:I136	3.53	No	Yes	0	6	4
189	R:R:P178	R:R:V177	3.53	No	No	0	4	3
190	R:R:L236	R:R:Y202	3.52	No	Yes	0	8	9
191	R:R:F259	R:R:Q260	3.51	Yes	No	0	4	4
192	R:R:K267	R:R:W270	3.48	No	No	0	3	2
193	R:R:D74	R:R:Y76	3.45	No	No	0	7	1
194	R:R:I61	R:R:P62	3.39	Yes	No	0	6	8
195	R:R:V32	R:R:V47	3.21	No	No	0	7	6
196	R:R:R295	R:R:R298	3.2	No	No	0	5	8
197	R:R:A55	R:R:L88	3.15	No	No	0	6	6
198	R:R:A244	R:R:L248	3.15	No	No	0	6	5
199	R:R:T118	R:R:T120	3.14	No	No	0	7	4
200	R:R:I107	R:R:V208	3.07	No	No	0	8	6
201	R:R:I239	R:R:V289	3.07	No	No	0	8	8
202	R:R:M272	R:R:V253	3.04	No	No	0	4	4
203	R:R:A133	R:R:Q90	3.03	No	Yes	0	7	5
204	R:R:F134	R:R:W130	3.01	No	Yes	0	3	9
205	R:R:L15	R:R:V11	2.98	No	No	0	5	7
206	R:R:L58	R:R:V22	2.98	No	No	0	6	5
207	R:R:L38	R:R:V32	2.98	Yes	No	0	8	7
208	R:R:L58	R:R:V54	2.98	No	No	0	6	7
209	R:R:L97	R:R:V101	2.98	No	No	0	7	7
210	R:R:L105	R:R:V101	2.98	No	No	0	6	7
211	R:R:L105	R:R:V117	2.98	No	No	0	6	7
212	R:R:L38	R:R:T37	2.95	Yes	No	0	8	6
213	R:R:D53	R:R:S92	2.94	Yes	No	0	9	9
214	R:R:I61	R:R:I65	2.94	Yes	No	0	6	7
215	R:R:I197	R:R:I201	2.94	No	No	0	6	7
216	R:R:I230	R:R:K234	2.91	No	No	0	4	7
217	R:R:G119	R:R:Y44	2.9	No	No	0	2	5
218	R:R:I197	R:R:L97	2.85	No	No	0	6	7
219	R:R:P41	R:R:Y44	2.78	No	No	0	6	5
220	R:R:L13	R:R:L9	2.77	No	No	0	4	5
221	R:R:A55	R:R:F59	2.77	No	No	0	6	5
222	R:R:A82	R:R:F173	2.77	No	Yes	0	5	4
223	R:R:E174	R:R:N175	2.63	No	No	0	5	5
224	R:R:D7	R:R:Q6	2.61	No	No	0	6	6
225	R:R:A52	R:R:W130	2.59	No	Yes	0	8	9
226	R:R:R228	R:R:T225	2.59	No	No	0	5	5
227	R:R:I304	R:R:R307	2.51	No	No	0	5	5
228	R:R:F141	R:R:L138	2.44	Yes	No	0	5	3
229	R:R:L116	R:R:R112	2.43	No	No	0	5	5
230	R:R:L27	R:R:Y292	2.34	No	Yes	0	6	6
231	R:R:G189	R:R:P193	2.03	No	No	0	3	4
232	R:R:A244	R:R:G241	1.95	No	No	0	6	5
233	R:R:A275	R:R:P249	1.87	No	No	0	6	9
234	R:R:G241	R:R:V240	1.84	No	No	0	5	8
235	R:R:A50	R:R:C29	1.81	No	No	0	9	8
236	R:R:P110	R:R:V109	1.77	No	No	0	8	5
237	R:R:G70	R:R:K170	1.74	No	No	0	4	5
238	R:R:C108	R:R:V109	1.71	No	No	0	7	5
239	R:R:G143	R:R:L142	1.71	No	No	0	4	4
240	R:R:A275	R:R:V250	1.7	No	No	0	6	5
241	R:R:A281	R:R:V284	1.7	No	Yes	0	5	6
242	R:R:C171	R:R:T73	1.69	No	No	0	9	7
243	R:R:D74	R:R:G77	1.68	No	No	0	7	5
244	R:R:M274	R:R:P249	1.68	No	No	0	3	9
245	R:R:K267	R:R:P268	1.67	No	No	0	3	3
246	R:R:C246	R:R:I242	1.64	No	No	0	8	7
247	R:R:L278	R:R:P249	1.64	No	No	0	7	9
248	R:R:V22	R:R:V26	1.6	No	No	0	5	4
249	R:R:V26	R:R:V54	1.6	No	No	0	4	7
250	R:R:T257	R:R:V253	1.59	No	No	0	4	4
251	R:R:T257	R:R:V256	1.59	No	No	0	4	3
252	R:R:A8	R:R:L3	1.58	No	No	0	4	8
253	R:R:I17	R:R:V284	1.54	No	Yes	0	6	6
254	R:R:I304	R:R:T300	1.52	No	No	0	5	7
255	R:R:F134	R:R:G135	1.51	No	No	0	3	3
256	R:R:L20	R:R:V284	1.49	No	Yes	0	5	6
257	R:R:L129	R:R:V125	1.49	No	No	0	6	6
258	R:R:L199	R:R:V240	1.49	No	No	0	5	8
259	R:R:L81	R:R:T66	1.47	No	No	0	6	4
260	R:R:I304	R:R:I305	1.47	No	No	0	5	5
261	R:R:A64	R:R:H280	1.46	No	Yes	0	6	7
262	R:R:G24	R:R:Y292	1.45	No	Yes	0	8	6
263	R:R:I136	R:R:L132	1.43	Yes	No	0	4	4
264	R:R:I203	R:R:L199	1.43	No	No	0	4	5
265	R:R:I203	R:R:L207	1.43	No	No	0	4	1
266	R:R:Q212	R:R:V208	1.43	No	No	0	7	6
267	R:R:K170	R:R:N175	1.4	No	No	0	5	5
268	R:R:L3	R:R:L69	1.38	No	No	0	8	4
269	R:R:L245	R:R:L278	1.38	No	No	0	6	7
270	R:R:H302	R:R:I305	1.33	No	No	0	5	5
271	R:R:F71	R:R:T66	1.3	No	No	0	6	4
272	R:R:R123	R:R:T120	1.29	No	No	0	1	4
273	R:R:R211	R:R:R215	1.07	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y10	11.502	5	1	6
2	R:R:E14	9.932	5	1	6
3	R:R:N25	8.0975	4	0	9
4	R:R:L38	4.98429	7	2	8
5	R:R:T42	5.4125	4	2	9
6	R:R:N43	5.365	6	2	9
7	R:R:F45	5.41	4	0	8
8	R:R:D53	7.456	5	1	9
9	R:R:I61	6.155	6	1	6
10	R:R:F75	8.2075	4	0	2
11	R:R:Q90	6.825	4	0	5
12	R:R:D102	7.3025	4	2	9
13	R:R:Y113	7.386	5	2	6
14	R:R:W130	5.986	5	0	9
15	R:R:I136	3.7225	4	0	4
16	R:R:F141	4.03	4	0	5
17	R:R:F173	13.444	5	1	4
18	R:R:Y181	11.272	5	1	6
19	R:R:M182	8.1275	4	1	4
20	R:R:F187	11.8725	4	1	6
21	R:R:F188	4.914	5	1	5
22	R:R:Y202	6.596	5	0	9
23	R:R:W247	9.27	6	1	7
24	R:R:H251	11.15	4	1	7
25	R:R:F259	4.29333	6	1	4
26	R:R:I276	6.4575	4	1	5
27	R:R:H280	7.705	4	1	7
28	R:R:V284	2.7975	4	0	6
29	R:R:N286	9.29	4	1	9
30	R:R:Y290	7.542	5	0	9
31	R:R:Y292	3.768	5	0	6
32	R:R:F297	8.312	5	2	8
33	L:L:?1	9.17917	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E14	R:R:I276	19.5407	5.47	Yes	Yes	1	6	5
2	L:L:?1	R:R:I276	44.2269	4.29	Yes	Yes	1	0	5
3	L:L:?1	R:R:N254	21.9317	6.19	Yes	No	1	0	5
4	R:R:N254	R:R:V250	21.1845	4.43	No	No	0	5	5
5	R:R:A275	R:R:V250	19.725	1.7	No	No	0	6	5
6	R:R:A275	R:R:P249	18.2556	1.87	No	No	0	6	9
7	R:R:M274	R:R:P249	13.7826	1.68	No	No	0	3	9
8	R:R:M274	R:R:W270	12.2734	4.65	No	No	0	3	2
9	R:R:E14	R:R:I61	14.4401	8.2	Yes	Yes	1	6	6
10	R:R:H280	R:R:I276	16.7663	3.98	Yes	Yes	1	7	5
11	R:R:H280	R:R:I61	14.1911	10.61	Yes	Yes	1	7	6
12	L:L:?1	R:R:W247	100	5.13	Yes	Yes	1	0	7
13	R:R:N282	R:R:W247	92.8372	13.56	No	Yes	1	8	7
14	R:R:N282	R:R:N286	94.7998	12.26	No	Yes	1	8	9
15	R:R:D53	R:R:N286	19.3863	6.73	Yes	Yes	1	9	9
16	R:R:D53	R:R:N25	13.5087	13.46	Yes	Yes	0	9	9
17	R:R:S21	R:R:V284	12.109	6.46	No	Yes	0	8	6
18	R:R:A291	R:R:F297	11.591	4.16	No	Yes	0	8	8
19	R:R:F297	R:R:N43	13.678	9.67	Yes	Yes	2	8	9
20	R:R:N43	R:R:T42	31.6049	4.39	Yes	Yes	2	9	9
21	R:R:D102	R:R:T42	40.3218	7.23	Yes	Yes	2	9	9
22	R:R:D102	R:R:F45	61.3568	9.55	Yes	Yes	0	9	8
23	R:R:F45	R:R:I126	64.0167	3.77	Yes	No	0	8	7
24	R:R:I126	R:R:S48	64.8685	6.19	No	No	0	7	9
25	R:R:S48	R:R:S95	56.1317	6.52	No	No	0	9	7
26	R:R:L49	R:R:S95	56.9337	6.01	No	No	0	9	7
27	R:R:L49	R:R:N286	51.8828	12.36	No	Yes	1	9	9
28	R:R:A291	R:R:V28	10.1564	5.09	No	No	0	8	9
29	R:R:L38	R:R:N43	15.0727	4.12	Yes	Yes	2	8	9
30	R:R:T40	R:R:T42	10.794	6.28	No	Yes	2	8	9
31	R:R:P41	R:R:T40	10.3158	5.25	No	No	0	6	8
32	R:R:I93	R:R:W247	12.0094	10.57	No	Yes	0	7	7
33	R:R:I93	R:R:Q90	11.3469	4.12	No	Yes	0	7	5
34	R:R:F94	R:R:Q90	17.0004	14.05	No	Yes	0	5	5
35	R:R:F94	R:R:L129	16.3479	4.87	No	No	0	5	6
36	R:R:L129	R:R:W130	16.318	4.56	No	Yes	0	6	9
37	R:R:G57	R:R:I61	11.571	5.29	No	Yes	0	7	6
38	L:L:?1	R:R:F173	32.2425	33.86	Yes	Yes	1	0	4
39	R:R:F173	R:R:L86	27.2315	6.09	Yes	No	1	4	3
40	R:R:L86	R:R:Y181	54.0396	4.69	No	Yes	1	3	6
41	R:R:P140	R:R:Y181	53.1381	18.08	No	Yes	0	4	6
42	R:R:C83	R:R:P140	51.0161	5.65	No	No	0	6	4
43	R:R:C83	R:R:F141	48.8842	4.19	No	Yes	0	6	5
44	R:R:F141	R:R:F80	38.0753	5.36	Yes	No	0	5	4
45	R:R:F80	R:R:F84	35.8836	5.36	No	No	0	4	4
46	R:R:F84	R:R:L88	18.5246	3.65	No	No	0	4	6
47	R:R:A55	R:R:L88	16.2433	3.15	No	No	0	6	6
48	R:R:A55	R:R:F59	13.952	2.77	No	No	0	6	5
49	L:L:?1	R:R:M182	27.645	9.56	Yes	Yes	1	0	4
50	R:R:L86	R:R:M182	28.7906	8.48	No	Yes	1	3	4
51	R:R:F59	R:R:L58	11.6507	4.87	No	No	0	5	6
52	R:R:F63	R:R:F84	15.7103	4.29	No	No	0	5	4
53	R:R:F63	R:R:L81	13.6979	18.27	No	No	0	5	6
54	R:R:C78	R:R:I67	12.3481	4.91	No	No	1	9	4
55	L:L:?1	R:R:I67	16.7314	8.58	Yes	No	1	0	4
56	R:R:L81	R:R:T66	11.3917	1.47	No	No	0	6	4
57	R:R:C78	R:R:V176	10.9085	5.12	No	No	0	9	1
58	R:R:C190	R:R:Q90	15.2222	6.1	No	Yes	0	6	5
59	R:R:N286	R:R:Y290	70.8906	5.81	Yes	Yes	0	9	9
60	R:R:D102	R:R:V117	22.5194	4.38	Yes	No	2	9	7
61	R:R:L105	R:R:V117	24.1433	2.98	No	No	0	6	7
62	R:R:L105	R:R:V101	22.7087	2.98	No	No	0	6	7
63	R:R:L97	R:R:V101	21.2642	2.98	No	No	0	7	7
64	R:R:R103	R:R:Y202	29.6374	5.14	No	Yes	0	9	9
65	R:R:R103	R:R:Y290	30.7233	10.29	No	Yes	0	9	9
66	R:R:I239	R:R:Y202	30.0558	12.09	No	Yes	0	8	9
67	R:R:I239	R:R:Y290	37.0791	4.84	No	Yes	0	8	9
68	R:R:I201	R:R:Y104	12.3879	15.71	No	No	0	7	8
69	R:R:I197	R:R:I201	13.8922	2.94	No	No	0	6	7
70	R:R:I197	R:R:L97	15.3865	2.85	No	No	0	6	7
71	R:R:L236	R:R:Y202	34.2	3.52	No	Yes	0	8	9
72	R:R:I205	R:R:L236	10.784	4.28	No	No	0	9	8
73	R:R:F185	R:R:Y181	14.6643	11.35	No	Yes	1	3	6
74	R:R:F185	R:R:I136	13.8773	5.02	No	Yes	0	3	4
75	R:R:C190	R:R:I136	14.1512	4.91	No	Yes	0	6	4
76	L:L:?1	R:R:H251	17.8472	5.8	Yes	Yes	1	0	7
77	R:R:F187	R:R:H251	16.6567	22.63	Yes	Yes	1	6	7
78	R:R:F187	R:R:F188	13.3692	8.57	Yes	Yes	1	6	5
79	R:R:V240	R:R:Y202	19.0377	5.05	No	Yes	0	8	9
80	R:R:C210	R:R:F206	16.0191	5.59	No	No	0	5	5
81	R:R:F206	R:R:L236	21.05	3.65	No	No	0	5	8
82	R:R:C210	R:R:E229	13.3094	6.08	No	No	0	5	7
83	L:L:?1	R:R:M179	10.2062	4.25	Yes	No	1	0	3
84	R:R:S48	R:R:W130	16.1387	4.94	No	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E14	R:R:Y10	14.59	1	Yes	Yes	6	6	2	2
R:R:S68	R:R:Y10	6.36	0	No	Yes	4	6	1	2
R:R:I276	R:R:Y10	12.09	1	Yes	Yes	5	6	1	2
R:R:E14	R:R:I276	5.47	1	Yes	Yes	6	5	2	1
R:R:E14	R:R:H280	14.77	1	Yes	Yes	6	7	2	2
R:R:C78	R:R:I67	4.91	1	No	No	9	4	2	1
R:R:C171	R:R:I67	4.91	1	No	No	9	4	2	1
L:L:?1	R:R:I67	8.58	1	Yes	No	0	4	0	1
L:L:?1	R:R:S68	11.28	1	Yes	No	0	4	0	1
R:R:C171	R:R:C78	7.28	1	No	No	9	9	2	2
R:R:F173	R:R:L86	6.09	1	Yes	No	4	3	1	2
R:R:L86	R:R:M182	8.48	1	No	Yes	3	4	2	1
L:L:?1	R:R:T89	6.64	1	Yes	No	0	6	0	1
R:R:I93	R:R:W247	10.57	0	No	Yes	7	7	2	1
R:R:F173	R:R:V177	17.04	1	Yes	No	4	3	1	2
R:R:F173	R:R:M182	7.46	1	Yes	Yes	4	4	1	1
L:L:?1	R:R:F173	33.86	1	Yes	Yes	0	4	0	1
R:R:E174	R:R:M179	4.06	0	No	No	5	3	2	1
R:R:M179	R:R:N254	5.61	1	No	No	3	5	1	1
L:L:?1	R:R:M179	4.25	1	Yes	No	0	3	0	1
R:R:M182	R:R:N186	7.01	1	Yes	No	4	5	1	1
L:L:?1	R:R:M182	9.56	1	Yes	Yes	0	4	0	1
R:R:H251	R:R:N186	5.1	1	Yes	No	7	5	1	1
L:L:?1	R:R:N186	10.32	1	Yes	No	0	5	0	1
R:R:F187	R:R:V191	6.55	1	Yes	No	6	7	2	2
R:R:F187	R:R:H251	22.63	1	Yes	Yes	6	7	2	1
R:R:H251	R:R:V191	11.07	1	Yes	No	7	7	1	2
R:R:F243	R:R:W247	15.03	0	No	Yes	9	7	2	1
R:R:C246	R:R:W247	3.92	1	No	Yes	8	7	2	1
R:R:C246	R:R:N282	7.87	1	No	No	8	8	2	2
R:R:S279	R:R:W247	7.41	0	No	Yes	7	7	2	1
R:R:N282	R:R:W247	13.56	1	No	Yes	8	7	2	1
L:L:?1	R:R:W247	5.13	1	Yes	Yes	0	7	0	1
R:R:N254	R:R:V250	4.43	1	No	No	5	5	1	2
L:L:?1	R:R:H251	5.8	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N254	6.19	1	Yes	No	0	5	0	1
L:L:?1	R:R:M272	4.25	1	Yes	No	0	4	0	1
R:R:H280	R:R:I276	3.98	1	Yes	Yes	7	5	2	1
L:L:?1	R:R:I276	4.29	1	Yes	Yes	0	5	0	1
R:R:M272	R:R:V253	3.04	0	No	No	4	4	1	2
R:R:A82	R:R:F173	2.77	0	No	Yes	5	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8HDO_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.65
Number of Linked Nodes	248
Number of Links	273
Number of Hubs	33
Number of Links mediated by Hubs	136
Number of Communities	2
Number of Nodes involved in Communities	44
Number of Links involved in Communities	66

Path Summary
Number Of Nodes in MetaPath	85
Number Of Links MetaPath	84
Number of Shortest Paths	44725
Length Of Smallest Path	3
Average Path Length	13.7902
Length of Longest Path	35
Minimum Path Strength	1.385
Average Path Strength	6.99293
Maximum Path Strength	25.45
Minimum Path Correlation	0.7
Average Path Correlation	0.922616
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	42.0905
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.564
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled adenosine receptor activity • regulation of tube diameter • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • regulation of biological quality • vasodilation • blood circulation • regulation of anatomical structure size • positive regulation of biological process • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • positive regulation of cellular process • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of chemokine production • regulation of gene expression • biosynthetic process • positive regulation of gene expression • chemokine production • positive regulation of chemokine production • positive regulation of multicellular organismal process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • positive regulation of chronic inflammatory response • regulation of defense response • chronic inflammatory response • regulation of response to external stimulus • regulation of chronic inflammatory response to non-antigenic stimulus • chronic inflammatory response to non-antigenic stimulus • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • positive regulation of chronic inflammatory response to non-antigenic stimulus • response to stress • regulation of response to stress • regulation of chronic inflammatory response • defense response • regulation of inflammatory response • response to external stimulus • regulation of response to stimulus • positive regulation of defense response • inflammatory response • establishment of organelle localization • regulated exocytosis • cellular localization • transport • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • vesicle-mediated transport • leukocyte activation • localization • secretion by cell • organelle localization • leukocyte activation involved in immune response • establishment of localization in cell • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • immune response • secretion • cell activation • vacuolar localization • export from cell • mast cell degranulation • establishment of localization • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • exocytosis • immune system process • lysosome localization • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • regulation of vascular endothelial growth factor production • vascular endothelial growth factor production • positive regulation of vascular endothelial growth factor production • interleukin-6 production • positive regulation of interleukin-6 production • regulation of interleukin-6 production • regulation of immune effector process • regulation of localization • regulation of myeloid leukocyte mediated immunity • positive regulation of leukocyte degranulation • positive regulation of regulated secretory pathway • regulation of immune system process • positive regulation of mast cell degranulation • positive regulation of immune system process • regulation of secretion • regulation of leukocyte mediated immunity • positive regulation of secretion by cell • positive regulation of exocytosis • regulation of mast cell degranulation • regulation of regulated secretory pathway • regulation of secretion by cell • positive regulation of secretion • positive regulation of immune effector process • regulation of leukocyte degranulation • regulation of transport • regulation of vesicle-mediated transport • positive regulation of transport • regulation of exocytosis • regulation of system process • negative regulation of biological process • negative regulation of muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • negative regulation of smooth muscle contraction • relaxation of smooth muscle • muscle contraction • muscle system process • regulation of muscle system process • relaxation of muscle • relaxation of vascular associated smooth muscle • regulation of muscle contraction • negative regulation of multicellular organismal process • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • Schaffer collateral - CA1 synapse • presynapse • glutamatergic synapse
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	I5D
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	I5D
Name	2-[6-azanyl-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl]sulfanylethanamide
Synonyms
Identifier
Formula	C19 H17 N5 O2 S
Molecular Weight	379.436
SMILES
PubChem	11717831
Formal Charge	0
Total Atoms	44
Total Chiral Atoms	0
Total Bonds	46
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P29275
Sequence	>8HDO_nogp_Chain_R L E T Q D A L Y V A L E L V I A A L S V A G N V L V C A A V G T A N T L Q T P T N Y F L V S L A A A D V A V G L F A I P F A I T I S L G F C T D F Y G C L F L A C F V L V L T Q S S I F S L L A V A V D R Y L A I C V P L R Y K S L V T G T R A R G V I A V L W V L A F G I G L T P F L G W N S K D V K C L F E N V V P M S Y M V Y F N F F G C V L P P L L I M L V I Y I K I F L V A C R Q L Q R T T T L Q R E I H A A K S L A M I V G I F A L C W L P V H A V N C V T L F Q P A K P K W A M N M A I L L S H A N S V V N P I V Y A Y R N R D F R Y T F H K I I S R Y L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HDO	A	Nucleotide	Adenosine	A_2B	Homo sapiens	BAY 60-6583	-	Gs/β1/γ2	2.87	2023-01-18	doi.org/10.1038/s41421-022-00503-1
	8HDO (No Gprot)	A	Nucleotide	Adenosine	A_2B	Homo sapiens	BAY 60-6583	-		2.87	2023-01-18	doi.org/10.1038/s41421-022-00503-1
	8HDP	A	Nucleotide	Adenosine	A_2B	Homo sapiens	Adenosine	-	Gs/β1/γ2	3.2	2023-01-18	doi.org/10.1038/s41421-022-00503-1
	8HDP (No Gprot)	A	Nucleotide	Adenosine	A_2B	Homo sapiens	Adenosine	-		3.2	2023-01-18	doi.org/10.1038/s41421-022-00503-1
	7XY6	A	Nucleotide	Adenosine	A_2B	Homo sapiens	BAY 60-6583	-	chim(NtGi1-Gs)/β1/γ2	2.99	2023-05-03	doi.org/10.1126/sciadv.add3709
	7XY6 (No Gprot)	A	Nucleotide	Adenosine	A_2B	Homo sapiens	BAY 60-6583	-		2.99	2023-05-03	doi.org/10.1126/sciadv.add3709
	7XY7	A	Nucleotide	Adenosine	A_2B	Homo sapiens	NECA	-	chim(NtGi1-Gs)/β1/γ2	3.26	2023-05-03	doi.org/10.1126/sciadv.add3709
	7XY7 (No Gprot)	A	Nucleotide	Adenosine	A_2B	Homo sapiens	NECA	-		3.26	2023-05-03	doi.org/10.1126/sciadv.add3709

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