psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:S1	R:R:S184	4.89	No	No	0	0	5
2	L:L:K3	R:R:D288	6.91	No	No	0	0	4
3	L:L:K3	R:R:E291	9.45	No	No	0	0	6
4	L:L:E4	L:L:R6	5.82	Yes	Yes	1	0	0
5	L:L:E4	R:R:R199	3.49	Yes	Yes	1	0	4
6	L:L:E4	R:R:R203	3.49	Yes	Yes	1	0	5
7	L:L:E4	R:R:D265	6.5	Yes	Yes	1	0	5
8	L:L:E4	R:R:R269	4.65	Yes	Yes	1	0	2
9	L:L:E4	R:R:L287	3.98	Yes	No	0	0	4
10	L:L:L5	R:R:Y188	16.41	No	No	0	0	4
11	L:L:R6	R:R:D265	4.76	Yes	Yes	1	0	5
12	L:L:R6	R:R:R269	7.46	Yes	Yes	1	0	2
13	L:L:R6	R:R:R280	17.06	Yes	No	0	0	1
14	L:L:C34	L:L:C7	7.28	No	No	0	0	0
15	L:L:Q8	R:R:P29	3.16	No	No	0	0	3
16	L:L:C50	L:L:C9	7.28	No	No	0	0	0
17	L:L:K11	R:R:D26	11.06	No	No	5	0	7
18	L:L:K11	R:R:Y27	7.17	No	Yes	5	0	4
19	L:L:D52	L:L:T12	4.34	No	No	0	0	0
20	L:L:K15	L:L:Y13	10.75	No	No	7	0	0
21	L:L:L49	L:L:Y13	5.86	Yes	No	0	0	0
22	L:L:Y13	R:R:P22	4.17	No	No	7	0	6
23	L:L:K15	R:R:P21	3.35	No	No	0	0	3
24	L:L:K15	R:R:P22	5.02	No	No	7	0	6
25	L:L:P16	L:L:W57	8.11	No	Yes	0	0	0
26	L:L:F17	L:L:I22	3.77	No	No	0	0	0
27	L:L:F17	L:L:W57	5.01	No	Yes	0	0	0
28	L:L:H18	L:L:P19	4.58	No	No	2	0	0
29	L:L:H18	L:L:K20	13.1	No	No	2	0	0
30	L:L:F21	L:L:H18	6.79	No	No	2	0	0
31	L:L:K20	L:L:P19	5.02	No	No	2	0	0
32	L:L:K64	L:L:P19	5.02	No	No	0	0	0
33	L:L:K20	L:L:R68	3.71	No	No	0	0	0
34	L:L:F21	L:L:L43	7.31	No	Yes	2	0	0
35	L:L:F21	L:L:R47	4.28	No	Yes	2	0	0
36	L:L:I22	L:L:V41	13.83	No	No	0	0	0
37	L:L:K23	L:L:L43	2.82	No	Yes	0	0	0
38	L:L:K23	L:L:S44	3.06	No	No	0	0	0
39	L:L:E24	L:L:R26	5.82	No	No	0	0	0
40	L:L:E24	L:L:K42	5.4	No	No	0	0	0
41	L:L:I39	L:L:L25	2.85	Yes	No	0	0	0
42	L:L:F65	L:L:L25	7.31	No	No	0	0	0
43	L:L:I40	L:L:R26	6.26	No	No	0	0	0
44	L:L:I39	L:L:V27	4.61	Yes	No	0	0	0
45	L:L:E38	L:L:I28	8.2	No	No	0	0	0
46	L:L:S30	L:L:T37	3.2	No	No	0	0	0
47	L:L:S30	R:R:N193	5.96	No	No	0	0	3
48	L:L:G31	L:L:P32	4.06	No	No	0	0	0
49	L:L:P32	R:R:Y178	13.91	No	No	0	0	2
50	L:L:C34	L:L:H33	4.42	No	No	0	0	0
51	L:L:C34	L:L:E38	7.6	No	No	0	0	0
52	L:L:N36	L:L:T37	2.92	No	No	0	0	0
53	L:L:P53	L:L:T37	6.99	No	No	0	0	0
54	L:L:I39	L:L:L51	4.28	Yes	Yes	0	0	0
55	L:L:I39	L:L:V62	3.07	Yes	No	0	0	0
56	L:L:I40	R:R:P29	3.39	No	No	0	0	3
57	L:L:L49	L:L:V41	4.47	Yes	No	0	0	0
58	L:L:G46	L:L:K42	3.49	No	No	0	0	0
59	L:L:E48	L:L:K42	10.8	No	No	0	0	0
60	L:L:D45	L:L:L43	13.57	No	Yes	2	0	0
61	L:L:L43	L:L:R47	6.07	Yes	Yes	2	0	0
62	L:L:D45	L:L:R47	13.1	No	Yes	2	0	0
63	L:L:R47	R:R:A23	2.77	Yes	No	0	0	3
64	L:L:E48	R:R:S28	7.19	No	No	0	0	5
65	L:L:L49	L:L:L51	2.77	Yes	Yes	0	0	0
66	L:L:L49	R:R:Y27	11.72	Yes	Yes	0	0	4
67	L:L:L51	L:L:W57	3.42	Yes	Yes	6	0	0
68	L:L:L51	L:L:V58	13.41	Yes	No	6	0	0
69	L:L:D52	L:L:P53	6.44	No	No	0	0	0
70	L:L:D52	L:L:K54	4.15	No	No	0	0	0
71	L:L:E55	L:L:W57	21.81	No	Yes	6	0	0
72	L:L:E55	L:L:V58	8.56	No	No	6	0	0
73	L:L:V58	L:L:W57	8.58	No	Yes	6	0	0
74	L:L:E63	L:L:Q59	8.92	No	No	0	0	0
75	L:L:K64	L:L:R60	3.71	No	No	0	0	0
76	L:L:E63	L:L:V62	5.7	No	No	0	0	0
77	L:L:K64	L:L:R68	17.33	No	No	0	0	0
78	R:R:D24	R:R:D26	17.3	No	No	5	6	7
79	R:R:D24	R:R:Y27	5.75	No	Yes	5	6	4
80	R:R:E25	R:R:S28	8.62	No	No	0	2	5
81	R:R:D26	R:R:Y27	5.75	No	Yes	5	7	4
82	R:R:C277	R:R:C30	7.28	No	No	0	6	8
83	R:R:L32	R:R:R280	4.86	No	No	0	2	1
84	R:R:E33	R:R:N281	13.15	No	No	0	3	3
85	R:R:K39	R:R:T36	3	No	No	8	4	2
86	R:R:T36	R:R:Y40	6.24	No	No	8	2	4
87	R:R:N38	R:R:R285	21.69	No	No	0	3	3
88	R:R:K39	R:R:Y40	8.36	No	No	8	4	4
89	R:R:K39	R:R:V100	7.59	No	No	0	4	4
90	R:R:V42	R:R:Y46	5.05	No	Yes	4	5	7
91	R:R:K99	R:R:V42	4.55	No	No	4	5	5
92	R:R:L92	R:R:Y46	4.69	No	Yes	4	7	7
93	R:R:A96	R:R:Y46	4	No	Yes	0	7	7
94	R:R:K99	R:R:Y46	3.58	No	Yes	4	5	7
95	R:R:I292	R:R:Y46	3.63	No	Yes	0	4	7
96	R:R:F295	R:R:Y46	6.19	Yes	Yes	4	7	7
97	R:R:L48	R:R:V49	2.98	No	No	0	5	7
98	R:R:L92	R:R:V49	2.98	No	No	0	7	7
99	R:R:C299	R:R:V49	3.42	No	No	0	6	7
100	R:R:F50	R:R:L54	10.96	No	No	0	5	6
101	R:R:A89	R:R:F50	2.77	No	No	0	5	5
102	R:R:F50	R:R:P93	4.33	No	No	0	5	9
103	R:R:C299	R:R:L52	9.52	No	No	0	6	5
104	R:R:N57	R:R:S53	5.96	No	No	0	9	8
105	R:R:A89	R:R:S53	3.42	No	No	0	5	8
106	R:R:S298	R:R:S53	4.89	No	No	0	8	8
107	R:R:D85	R:R:N57	9.42	No	No	0	9	9
108	R:R:N57	R:R:P302	6.52	No	Yes	0	9	9
109	R:R:F307	R:R:L59	4.87	No	No	0	7	7
110	R:R:F316	R:R:L59	6.09	No	No	0	7	7
111	R:R:A82	R:R:V60	3.39	No	Yes	0	9	8
112	R:R:P302	R:R:V60	3.53	Yes	Yes	0	9	8
113	R:R:A306	R:R:V60	5.09	No	Yes	9	6	8
114	R:R:F312	R:R:V60	5.24	Yes	Yes	9	8	8
115	R:R:L79	R:R:M61	2.83	Yes	No	0	5	6
116	R:R:L83	R:R:M61	4.24	No	No	0	5	6
117	R:R:L62	R:R:Y66	8.21	No	No	0	3	5
118	R:R:F312	R:R:V63	11.8	Yes	No	0	8	7
119	R:R:F316	R:R:V63	3.93	No	No	0	7	7
120	R:R:D75	R:R:I64	2.8	No	Yes	0	8	6
121	R:R:I64	R:R:L79	2.85	Yes	Yes	0	6	5
122	R:R:F312	R:R:I64	3.77	Yes	Yes	0	8	6
123	R:R:L65	R:R:L79	2.77	No	Yes	0	2	5
124	R:R:I319	R:R:Y66	6.04	No	No	0	6	5
125	R:R:D75	R:R:S72	7.36	No	No	0	8	7
126	R:R:D134	R:R:V73	2.92	No	No	10	8	6
127	R:R:K149	R:R:V73	7.59	Yes	No	10	6	6
128	R:R:V153	R:R:V73	3.21	No	No	0	8	6
129	R:R:V153	R:R:V76	4.81	No	No	0	8	6
130	R:R:C130	R:R:Y77	5.38	No	Yes	0	5	7
131	R:R:I131	R:R:Y77	7.25	No	Yes	0	8	7
132	R:R:D134	R:R:Y77	5.75	No	Yes	0	8	7
133	R:R:V153	R:R:Y77	5.05	No	Yes	0	8	7
134	R:R:L79	R:R:N80	2.75	Yes	No	0	5	9
135	R:R:C157	R:R:N80	6.3	No	No	0	7	9
136	R:R:N80	R:R:W161	3.39	No	No	0	9	9
137	R:R:L127	R:R:L81	4.15	No	No	0	7	9
138	R:R:L128	R:R:L81	4.15	No	No	0	8	9
139	R:R:L81	R:R:N301	10.98	No	Yes	0	9	9
140	R:R:L83	R:R:L87	4.15	No	No	0	5	7
141	R:R:D85	R:R:S298	4.42	No	No	0	9	8
142	R:R:D85	R:R:N301	10.77	No	Yes	0	9	9
143	R:R:F88	R:R:K117	4.96	No	No	0	6	6
144	R:R:F88	R:R:N120	13.29	No	No	0	6	8
145	R:R:F295	R:R:F88	5.36	Yes	No	0	7	6
146	R:R:L116	R:R:T91	4.42	No	No	0	5	6
147	R:R:F295	R:R:L92	3.65	Yes	No	4	7	7
148	R:R:F105	R:R:I94	5.02	Yes	No	0	6	6
149	R:R:I94	R:R:V113	4.61	No	No	0	6	5
150	R:R:W103	R:R:W95	3.75	Yes	No	0	9	6
151	R:R:K117	R:R:W95	10.44	No	No	0	6	6
152	R:R:A97	R:R:F105	2.77	No	Yes	0	5	6
153	R:R:S98	R:R:W103	7.41	No	Yes	0	5	9
154	R:R:D288	R:R:K99	4.15	No	No	0	4	5
155	R:R:N101	R:R:V100	5.91	No	No	0	4	4
156	R:R:G102	R:R:S184	3.71	No	No	0	5	5
157	R:R:F105	R:R:W103	6.01	Yes	Yes	0	6	9
158	R:R:C110	R:R:W103	5.22	Yes	Yes	1	9	9
159	R:R:A177	R:R:W103	3.89	No	Yes	1	3	9
160	R:R:C187	R:R:W103	15.67	No	Yes	1	9	9
161	R:R:F105	R:R:L109	7.31	Yes	No	0	6	6
162	R:R:K111	R:R:T107	3	No	No	0	8	4
163	R:R:Q176	R:R:T107	8.5	No	No	0	4	4
164	R:R:L109	R:R:V112	2.98	No	No	0	6	5
165	R:R:C110	R:R:R175	4.18	Yes	Yes	1	9	4
166	R:R:A177	R:R:C110	3.61	No	Yes	1	3	9
167	R:R:C110	R:R:C187	7.28	Yes	No	1	9	9
168	R:R:R175	R:R:S114	11.86	Yes	No	0	4	5
169	R:R:L115	R:R:V119	2.98	No	No	12	5	5
170	R:R:L115	R:R:S168	6.01	No	No	12	5	7
171	R:R:F172	R:R:L115	12.18	No	No	0	4	5
172	R:R:L116	R:R:N120	2.75	No	No	0	5	8
173	R:R:E118	R:R:K117	10.8	Yes	No	0	5	6
174	R:R:E118	R:R:F121	4.66	Yes	No	0	5	7
175	R:R:E118	R:R:S168	4.31	Yes	No	0	5	7
176	R:R:E118	R:R:F171	10.49	Yes	No	0	5	4
177	R:R:S168	R:R:V119	3.23	No	No	12	7	5
178	R:R:F121	R:R:Y122	6.19	No	Yes	0	7	7
179	R:R:F121	R:R:W255	8.02	No	Yes	0	7	9
180	R:R:L167	R:R:Y122	4.69	No	Yes	0	5	7
181	R:R:P206	R:R:Y122	4.17	No	Yes	0	5	7
182	R:R:G210	R:R:Y122	2.9	No	Yes	0	6	7
183	R:R:S123	R:R:W161	12.36	No	No	0	7	9
184	R:R:S123	R:R:S164	6.52	No	No	0	7	8
185	R:R:I125	R:R:P214	3.39	No	No	0	8	9
186	R:R:I125	R:R:W255	12.92	No	Yes	0	8	9
187	R:R:L126	R:R:L163	4.15	No	No	0	5	4
188	R:R:C130	R:R:L127	3.17	No	No	11	5	7
189	R:R:C160	R:R:L127	4.76	No	No	11	6	7
190	R:R:H297	R:R:L128	3.86	Yes	No	0	9	8
191	R:R:L128	R:R:Y305	5.86	No	Yes	0	8	9
192	R:R:A129	R:R:V217	3.39	No	No	0	6	7
193	R:R:C130	R:R:C160	3.64	No	No	11	5	6
194	R:R:I131	R:R:R135	6.26	No	No	0	8	9
195	R:R:M218	R:R:S132	3.07	No	No	0	8	9
196	R:R:C221	R:R:S132	5.16	No	No	0	6	9
197	R:R:S132	R:R:Y222	13.99	No	Yes	0	9	8
198	R:R:C221	R:R:V133	3.42	No	No	0	6	6
199	R:R:D134	R:R:K149	8.3	No	Yes	10	8	6
200	R:R:R135	R:R:Y222	9.26	No	Yes	0	9	8
201	R:R:R135	R:R:Y305	6.17	No	Yes	0	9	9
202	R:R:V140	R:R:Y136	11.36	Yes	Yes	3	7	7
203	R:R:H141	R:R:Y136	7.62	Yes	Yes	3	6	7
204	R:R:C221	R:R:Y136	5.38	No	Yes	0	6	7
205	R:R:F224	R:R:Y136	7.22	No	Yes	0	4	7
206	R:R:H141	R:R:L137	3.86	Yes	No	0	6	5
207	R:R:A138	R:R:K149	3.21	No	Yes	0	8	6
208	R:R:I139	R:R:T225	4.56	No	Yes	0	8	8
209	R:R:I139	R:R:T228	3.04	No	No	0	8	5
210	R:R:H141	R:R:V140	4.15	Yes	Yes	3	6	7
211	R:R:T225	R:R:V140	3.17	Yes	Yes	3	8	7
212	R:R:T228	R:R:V140	6.35	No	Yes	0	5	7
213	R:R:H141	R:R:L146	9	Yes	No	0	6	5
214	R:R:T143	R:R:T145	4.71	No	No	0	5	5
215	R:R:R144	R:R:T147	11.64	No	No	0	4	5
216	R:R:R144	R:R:R150	5.33	No	No	0	4	3
217	R:R:L146	R:R:T145	4.42	No	No	0	5	5
218	R:R:L146	R:R:Q148	3.99	No	No	0	5	3
219	R:R:K149	R:R:T147	4.5	Yes	No	0	6	5
220	R:R:F209	R:R:L163	4.87	No	No	0	4	4
221	R:R:L169	R:R:N166	2.75	No	No	0	3	4
222	R:R:L167	R:R:L205	4.15	No	No	0	5	3
223	R:R:F209	R:R:L167	3.65	No	No	0	4	5
224	R:R:F174	R:R:P170	2.89	No	No	0	4	8
225	R:R:L202	R:R:P170	3.28	No	No	0	5	8
226	R:R:F171	R:R:R175	6.41	No	Yes	1	4	4
227	R:R:E189	R:R:F171	4.66	Yes	No	1	5	4
228	R:R:F174	R:R:L191	4.87	No	Yes	0	4	5
229	R:R:C187	R:R:R175	4.18	No	Yes	1	9	4
230	R:R:E189	R:R:R175	8.14	Yes	Yes	1	5	4
231	R:R:Q176	R:R:V190	7.16	No	No	0	4	4
232	R:R:P180	R:R:Y178	13.91	No	No	0	3	2
233	R:R:V190	R:R:Y178	5.05	No	No	0	4	2
234	R:R:H179	R:R:P185	9.15	No	No	0	3	4
235	R:R:P180	R:R:V186	3.53	No	No	0	3	4
236	R:R:P185	R:R:S184	3.56	No	No	0	4	5
237	R:R:R199	R:R:Y188	16.46	Yes	No	0	4	4
238	R:R:E189	R:R:R199	3.49	Yes	Yes	1	5	4
239	R:R:E189	R:R:L202	3.98	Yes	No	0	5	5
240	R:R:G192	R:R:L191	3.42	No	Yes	0	5	5
241	R:R:L191	R:R:T195	5.9	Yes	No	0	5	4
242	R:R:L191	R:R:W198	7.97	Yes	No	0	5	3
243	R:R:D194	R:R:K197	9.68	No	No	0	3	1
244	R:R:A196	R:R:R269	2.77	No	Yes	0	1	2
245	R:R:R199	R:R:R203	6.4	Yes	Yes	1	4	5
246	R:R:M200	R:R:T266	6.02	No	No	0	3	5
247	R:R:M200	R:R:R269	4.96	No	Yes	0	3	2
248	R:R:H207	R:R:R203	3.39	No	Yes	1	6	5
249	R:R:L262	R:R:R203	14.58	Yes	Yes	1	6	5
250	R:R:I204	R:R:T208	3.04	No	No	0	4	5
251	R:R:H207	R:R:N259	11.48	No	No	0	6	8
252	R:R:H207	R:R:L262	6.43	No	Yes	1	6	6
253	R:R:F209	R:R:T208	6.49	No	No	0	4	5
254	R:R:F211	R:R:L256	7.31	Yes	No	0	8	5
255	R:R:F211	R:R:N259	9.67	Yes	No	0	8	8
256	R:R:F216	R:R:I212	3.77	No	No	0	3	4
257	R:R:P214	R:R:V213	3.53	No	No	0	9	5
258	R:R:L215	R:R:L252	4.15	No	No	0	6	5
259	R:R:F251	R:R:M218	4.98	No	No	0	9	8
260	R:R:F220	R:R:F224	6.43	No	No	0	4	4
261	R:R:T225	R:R:Y222	3.75	Yes	Yes	3	8	8
262	R:R:I244	R:R:Y222	12.09	No	Yes	3	7	8
263	R:R:V248	R:R:Y222	3.79	No	Yes	0	8	8
264	R:R:I244	R:R:T225	3.04	No	Yes	3	7	8
265	R:R:L226	R:R:M241	4.24	No	No	0	4	6
266	R:R:I244	R:R:L226	4.28	No	No	0	7	4
267	R:R:A232	R:R:M234	3.22	No	Yes	0	3	4
268	R:R:K237	R:R:M234	5.76	No	Yes	13	7	4
269	R:R:H238	R:R:K237	7.86	No	No	0	5	7
270	R:R:Q310	R:R:R239	5.84	No	No	0	5	7
271	R:R:R239	R:R:R313	5.33	No	No	0	7	8
272	R:R:I308	R:R:V243	6.14	No	No	0	6	7
273	R:R:A246	R:R:I304	3.25	No	No	0	5	8
274	R:R:V247	R:R:Y305	6.31	No	Yes	0	7	9
275	R:R:H297	R:R:I250	6.63	Yes	No	0	9	6
276	R:R:I250	R:R:I304	2.94	No	No	0	6	8
277	R:R:F251	R:R:W255	7.02	No	Yes	0	9	9
278	R:R:C254	R:R:H297	8.85	No	Yes	0	8	9
279	R:R:G294	R:R:W255	5.63	No	Yes	0	8	9
280	R:R:H297	R:R:W255	6.35	Yes	Yes	0	9	9
281	R:R:L256	R:R:P257	4.93	No	No	0	5	9
282	R:R:L256	R:R:L260	4.15	No	No	0	5	6
283	R:R:P257	R:R:T290	3.5	No	No	0	9	7
284	R:R:L262	R:R:Y258	8.21	Yes	No	0	6	6
285	R:R:L262	R:R:L287	4.15	Yes	No	0	6	4
286	R:R:L263	R:R:L267	2.77	No	No	0	6	4
287	R:R:D265	R:R:R269	9.53	Yes	Yes	1	5	2
288	R:R:D265	R:R:I283	4.2	Yes	No	0	5	4
289	R:R:L267	R:R:V272	8.94	No	No	14	4	3
290	R:R:I273	R:R:L267	5.71	Yes	No	14	4	4
291	R:R:I273	R:R:M268	5.83	Yes	Yes	0	4	1
292	R:R:E275	R:R:M268	4.06	No	Yes	0	3	1
293	R:R:T270	R:R:V272	3.17	No	No	0	1	3
294	R:R:E275	R:R:Q271	5.1	No	No	0	3	1
295	R:R:I273	R:R:V272	3.07	Yes	No	14	4	3
296	R:R:I273	R:R:Q274	5.49	Yes	No	0	4	1
297	R:R:E278	R:R:S276	8.62	No	No	0	4	5
298	R:R:E291	R:R:F295	10.49	No	Yes	0	6	7
299	R:R:L293	R:R:L296	2.77	No	No	0	7	5
300	R:R:L296	R:R:L300	6.92	No	No	0	5	6
301	R:R:N301	R:R:P302	3.26	Yes	Yes	0	9	9
302	R:R:N301	R:R:Y305	5.81	Yes	Yes	0	9	9
303	R:R:I304	R:R:Y305	3.63	No	Yes	0	8	9
304	R:R:A306	R:R:F312	8.32	No	Yes	9	6	8
305	R:R:F307	R:R:F312	5.36	No	Yes	0	7	8
306	L:L:E55	L:L:N56	2.63	No	No	0	0	0
307	L:L:R60	L:L:V61	2.62	No	No	0	0	0
308	R:R:A84	R:R:W161	2.59	No	No	0	8	9
309	L:L:H33	R:R:N181	2.55	No	No	0	0	3
310	R:R:S28	R:R:Y27	2.54	No	Yes	0	5	4
311	R:R:V156	R:R:Y77	2.52	No	Yes	0	5	7
312	R:R:F307	R:R:I303	2.51	No	No	0	7	7
313	R:R:F230	R:R:M241	2.49	No	No	0	4	6
314	R:R:F172	R:R:K111	2.48	No	No	0	4	8
315	R:R:M268	R:R:R279	2.48	Yes	No	0	1	4
316	R:R:F172	R:R:L173	2.44	No	No	0	4	4
317	R:R:F211	R:R:L215	2.44	Yes	No	0	8	6
318	R:R:F251	R:R:L215	2.44	No	No	0	9	6
319	R:R:F245	R:R:L226	2.44	No	No	0	4	4
320	R:R:Q236	R:R:R239	2.34	No	No	0	5	7
321	R:R:K197	R:R:W198	2.32	No	No	0	1	3
322	R:R:G56	R:R:P302	2.03	No	Yes	0	7	9
323	L:L:R60	L:L:W57	2	No	Yes	0	0	0
324	R:R:A84	R:R:G124	1.95	No	No	0	8	9
325	L:L:C9	R:R:P29	1.88	No	No	0	0	3
326	R:R:A129	R:R:P214	1.87	No	No	0	6	9
327	R:R:G102	R:R:S98	1.86	No	No	0	5	5
328	R:R:P180	R:R:S183	1.78	No	No	0	3	3
329	R:R:G284	R:R:I283	1.76	No	No	0	4	4
330	R:R:G309	R:R:I308	1.76	No	No	0	8	6
331	R:R:G162	R:R:M165	1.75	No	No	0	4	3
332	R:R:G235	R:R:M234	1.75	No	Yes	0	3	4
333	R:R:G56	R:R:L55	1.71	No	No	0	7	5
334	R:R:A45	R:R:V41	1.7	No	No	0	5	5
335	R:R:A286	R:R:V261	1.7	No	No	0	4	5
336	R:R:L169	R:R:P170	1.64	No	No	0	3	8
337	R:R:G235	R:R:Q236	1.64	No	No	0	3	5
338	R:R:L293	R:R:P257	1.64	No	No	0	7	9
339	R:R:A45	R:R:I292	1.62	No	No	0	5	4
340	R:R:A264	R:R:M268	1.61	No	Yes	0	4	1
341	L:L:S1	R:R:T34	1.6	No	No	0	0	5
342	R:R:S72	R:R:T74	1.6	No	No	0	7	7
343	R:R:A306	R:R:L78	1.58	No	No	0	6	8
344	R:R:A240	R:R:L229	1.58	No	Yes	0	7	8
345	R:R:C277	R:R:N281	1.57	No	No	0	6	3
346	R:R:I43	R:R:V100	1.54	No	No	0	6	4
347	L:L:H33	L:L:P32	1.53	No	No	0	0	0
348	L:L:C9	L:L:E38	1.52	No	No	0	0	0
349	R:R:K154	R:R:V76	1.52	No	No	0	3	6
350	R:R:M165	R:R:V119	1.52	No	No	0	3	5
351	R:R:F105	R:R:G106	1.51	Yes	No	0	6	8
352	R:R:L86	R:R:S58	1.5	No	No	0	7	2
353	R:R:G309	R:R:R313	1.5	No	No	0	8	8
354	L:L:L66	L:L:V27	1.49	No	No	0	0	0
355	R:R:L152	R:R:V156	1.49	No	No	0	3	5
356	R:R:L219	R:R:V248	1.49	No	No	0	4	8
357	R:R:L287	R:R:V261	1.49	No	No	0	4	5
358	R:R:N38	R:R:V42	1.48	No	No	0	3	5
359	R:R:I43	R:R:I44	1.47	No	No	0	6	5
360	R:R:L229	R:R:T228	1.47	Yes	No	0	8	5
361	R:R:I283	R:R:M268	1.46	No	Yes	0	4	1
362	L:L:I10	L:L:K11	1.45	No	No	0	0	0
363	R:R:I319	R:R:K318	1.45	No	No	0	6	5
364	R:R:I44	R:R:L48	1.43	No	No	0	5	5
365	R:R:I250	R:R:L249	1.43	No	No	0	6	5
366	R:R:L86	R:R:M61	1.41	No	No	0	7	6
367	R:R:L229	R:R:M234	1.41	Yes	Yes	13	8	4
368	R:R:K237	R:R:L229	1.41	No	Yes	13	7	8
369	R:R:L54	R:R:L90	1.38	No	No	0	6	5
370	R:R:L59	R:R:L62	1.38	No	No	0	7	3
371	L:L:E63	L:L:K67	1.35	No	No	0	0	0
372	R:R:R279	R:R:S276	1.32	No	No	0	4	5
373	R:R:E35	R:R:N38	1.31	No	No	0	1	3
374	R:R:F105	R:R:I104	1.26	Yes	No	0	6	3
375	R:R:F211	R:R:I212	1.26	Yes	No	0	8	4
376	R:R:I64	R:R:R71	1.25	Yes	No	0	6	6
377	L:L:R26	R:R:N182	1.21	No	No	0	0	7
378	R:R:L37	R:R:Y40	1.17	No	No	0	2	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:E4	4.655	6	1	0
2	L:L:R6	8.775	4	1	0
3	L:L:I39	3.7025	4	0	0
4	L:L:L43	7.4425	4	2	0
5	L:L:R47	6.555	4	2	0
6	L:L:L49	6.205	4	0	0
7	L:L:L51	5.97	4	6	0
8	L:L:W57	8.155	6	6	0
9	R:R:Y27	6.586	5	5	4
10	R:R:Y46	4.52333	6	4	7
11	R:R:V60	4.3125	4	9	8
12	R:R:I64	2.6675	4	0	6
13	R:R:Y77	5.19	5	0	7
14	R:R:L79	2.8	4	0	5
15	R:R:W103	6.99167	6	1	9
16	R:R:F105	3.98	6	0	6
17	R:R:C110	5.0725	4	1	9
18	R:R:E118	7.565	4	0	5
19	R:R:Y122	4.4875	4	0	7
20	R:R:Y136	7.895	4	3	7
21	R:R:V140	6.2575	4	3	7
22	R:R:H141	6.1575	4	3	6
23	R:R:K149	5.9	4	10	6
24	R:R:R175	6.954	5	1	4
25	R:R:E189	5.0675	4	1	5
26	R:R:L191	5.54	4	0	5
27	R:R:R199	7.46	4	1	4
28	R:R:R203	6.965	4	1	5
29	R:R:F211	5.17	4	0	8
30	R:R:Y222	8.576	5	3	8
31	R:R:T225	3.63	4	3	8
32	R:R:L229	1.4675	4	13	8
33	R:R:M234	3.035	4	13	4
34	R:R:W255	7.988	5	0	9
35	R:R:L262	8.3425	4	1	6
36	R:R:D265	6.2475	4	1	5
37	R:R:M268	3.088	5	0	1
38	R:R:R269	5.874	5	1	2
39	R:R:I273	5.025	4	14	4
40	R:R:F295	6.4225	4	4	7
41	R:R:H297	6.4225	4	0	9
42	R:R:N301	7.705	4	0	9
43	R:R:P302	3.835	4	0	9
44	R:R:Y305	5.556	5	0	9
45	R:R:F312	6.898	5	9	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F295	R:R:F88	25.4628	5.36	Yes	No	0	7	6
2	R:R:F88	R:R:K117	28.8248	4.96	No	No	0	6	6
3	R:R:K117	R:R:W95	14.9264	10.44	No	No	0	6	6
4	R:R:W103	R:R:W95	14.2562	3.75	Yes	No	0	9	6
5	R:R:F295	R:R:Y46	10.058	6.19	Yes	Yes	4	7	7
6	L:L:E4	R:R:R199	20.2862	3.49	Yes	Yes	1	0	4
7	R:R:E189	R:R:R199	26.1805	3.49	Yes	Yes	1	5	4
8	L:L:E4	R:R:D265	15.9285	6.5	Yes	Yes	1	0	5
9	L:L:C34	L:L:H33	53.3264	4.42	No	No	0	0	0
10	L:L:H33	L:L:P32	54.71	1.53	No	No	0	0	0
11	L:L:P32	R:R:Y178	56.0764	13.91	No	No	0	0	2
12	R:R:V190	R:R:Y178	58.7574	5.05	No	No	0	4	2
13	R:R:Q176	R:R:V190	59.4168	7.16	No	No	0	4	4
14	R:R:Q176	R:R:T107	60.072	8.5	No	No	0	4	4
15	R:R:K111	R:R:T107	60.7228	3	No	No	0	8	4
16	R:R:F172	R:R:K111	61.3694	2.48	No	No	0	4	8
17	R:R:F172	R:R:L115	62.6495	12.18	No	No	0	4	5
18	R:R:L115	R:R:S168	62.7724	6.01	No	No	12	5	7
19	R:R:E118	R:R:S168	65.7744	4.31	Yes	No	0	5	7
20	R:R:E118	R:R:K117	41.7383	10.8	Yes	No	0	5	6
21	L:L:C9	R:R:P29	49.0873	1.88	No	No	0	0	3
22	L:L:C9	L:L:E38	50.5205	1.52	No	No	0	0	0
23	L:L:C34	L:L:E38	51.9234	7.6	No	No	0	0	0
24	R:R:S28	R:R:Y27	40.9129	2.54	No	Yes	0	5	4
25	L:L:E48	R:R:S28	42.4431	7.19	No	No	0	0	5
26	L:L:E48	L:L:K42	43.2017	10.8	No	No	0	0	0
27	L:L:E24	L:L:K42	44.7059	5.4	No	No	0	0	0
28	L:L:E24	L:L:R26	45.4516	5.82	No	No	0	0	0
29	L:L:I40	L:L:R26	46.93	6.26	No	No	0	0	0
30	L:L:I40	R:R:P29	47.6326	3.39	No	No	0	0	3
31	L:L:L49	R:R:Y27	37.0121	11.72	Yes	Yes	0	0	4
32	L:L:L51	L:L:W57	19.2474	3.42	Yes	Yes	6	0	0
33	L:L:L49	L:L:L51	30.411	2.77	Yes	Yes	0	0	0
34	L:L:K64	L:L:P19	10.3317	5.02	No	No	0	0	0
35	L:L:K64	L:L:R60	13.1183	3.71	No	No	0	0	0
36	L:L:R60	L:L:W57	14.9242	2	No	Yes	0	0	0
37	R:R:F295	R:R:L92	11.9049	3.65	Yes	No	4	7	7
38	R:R:L92	R:R:V49	11.2993	2.98	No	No	0	7	7
39	R:R:E118	R:R:F121	98.4354	4.66	Yes	No	0	5	7
40	R:R:F121	R:R:W255	100	8.02	No	Yes	0	7	9
41	R:R:H297	R:R:W255	75.8324	6.35	Yes	Yes	0	9	9
42	R:R:H297	R:R:L128	73.7549	3.86	Yes	No	0	9	8
43	R:R:L128	R:R:L81	37.0466	4.15	No	No	0	8	9
44	R:R:L81	R:R:N301	31.2989	10.98	No	Yes	0	9	9
45	R:R:D85	R:R:N301	17.9328	10.77	No	Yes	0	9	9
46	R:R:N57	R:R:S53	14.7928	5.96	No	No	0	9	8
47	R:R:A89	R:R:S53	18.2194	3.42	No	No	0	5	8
48	R:R:A89	R:R:F50	14.5837	2.77	No	No	0	5	5
49	R:R:L128	R:R:Y305	37.2169	5.86	No	Yes	0	8	9
50	R:R:N301	R:R:Y305	39.038	5.81	Yes	Yes	0	9	9
51	R:R:N301	R:R:P302	51.0916	3.26	Yes	Yes	0	9	9
52	R:R:P302	R:R:V60	40.15	3.53	Yes	Yes	0	9	8
53	R:R:F312	R:R:V60	35.4044	5.24	Yes	Yes	9	8	8
54	R:R:F312	R:R:I64	23.7064	3.77	Yes	Yes	0	8	6
55	R:R:I64	R:R:L79	17.6182	2.85	Yes	Yes	0	6	5
56	R:R:L127	R:R:L81	10.0343	4.15	No	No	0	7	9
57	R:R:R135	R:R:Y305	17.8983	6.17	No	Yes	0	9	9
58	R:R:I131	R:R:R135	12.3122	6.26	No	No	0	8	9
59	R:R:I131	R:R:Y77	11.5515	7.25	No	Yes	0	8	7
60	R:R:F251	R:R:W255	37.0811	7.02	No	Yes	0	9	9
61	R:R:F251	R:R:M218	35.1135	4.98	No	No	0	9	8
62	R:R:M218	R:R:S132	34.9367	3.07	No	No	0	8	9
63	R:R:C221	R:R:S132	14.1139	5.16	No	No	0	6	9
64	R:R:S132	R:R:Y222	22.7129	13.99	No	Yes	0	9	8
65	R:R:C221	R:R:Y136	12.8252	5.38	No	Yes	0	6	7
66	R:R:T225	R:R:Y222	24.3551	3.75	Yes	Yes	3	8	8
67	R:R:T225	R:R:V140	13.0881	3.17	Yes	Yes	3	8	7
68	R:R:I139	R:R:T225	11.1614	4.56	No	Yes	0	8	8
69	R:R:T228	R:R:V140	18.0794	6.35	No	Yes	0	5	7
70	R:R:I139	R:R:T228	10.4912	3.04	No	No	0	8	5
71	R:R:E189	R:R:L202	10.8554	3.98	Yes	No	0	5	5
72	R:R:H207	R:R:N259	10.823	11.48	No	No	0	6	8
73	R:R:F251	R:R:L215	18.8099	2.44	No	No	0	9	6
74	R:R:F211	R:R:L215	17.3789	2.44	Yes	No	0	8	6
75	R:R:F211	R:R:N259	11.1722	9.67	Yes	No	0	8	8
76	R:R:L229	R:R:T228	26.6438	1.47	Yes	No	0	8	5
77	R:R:L229	R:R:M234	19.0492	1.41	Yes	Yes	13	8	4
78	R:R:G235	R:R:M234	15.2906	1.75	No	Yes	0	3	4
79	R:R:G235	R:R:Q236	13.3833	1.64	No	No	0	3	5
80	R:R:Q236	R:R:R239	11.4717	2.34	No	No	0	5	7
81	R:R:D265	R:R:I283	15.1915	4.2	Yes	No	0	5	4
82	R:R:I283	R:R:M268	13.2217	1.46	No	Yes	0	4	1
83	R:R:E189	R:R:F171	30.8205	4.66	Yes	No	1	5	4
84	R:R:E118	R:R:F171	35.2794	10.49	Yes	No	0	5	4
85	R:R:R135	R:R:Y222	12.6032	9.26	No	Yes	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:S1	R:R:S184	4.89	0	No	No	0	5	0	1
L:L:K3	R:R:D288	6.91	0	No	No	0	4	0	1
L:L:K3	R:R:E291	9.45	0	No	No	0	6	0	1
L:L:E4	R:R:R199	3.49	1	Yes	Yes	0	4	0	1
L:L:E4	R:R:R203	3.49	1	Yes	Yes	0	5	0	1
L:L:E4	R:R:D265	6.5	1	Yes	Yes	0	5	0	1
L:L:E4	R:R:R269	4.65	1	Yes	Yes	0	2	0	1
L:L:E4	R:R:L287	3.98	1	Yes	No	0	4	0	1
L:L:L5	R:R:Y188	16.41	0	No	No	0	4	0	1
L:L:R6	R:R:D265	4.76	1	Yes	Yes	0	5	0	1
L:L:R6	R:R:R269	7.46	1	Yes	Yes	0	2	0	1
L:L:R6	R:R:R280	17.06	1	Yes	No	0	1	0	1
L:L:Q8	R:R:P29	3.16	0	No	No	0	3	0	1
L:L:K11	R:R:D26	11.06	5	No	No	0	7	0	1
L:L:K11	R:R:Y27	7.17	5	No	Yes	0	4	0	1
L:L:Y13	R:R:P22	4.17	7	No	No	0	6	0	1
L:L:K15	R:R:P21	3.35	7	No	No	0	3	0	1
L:L:K15	R:R:P22	5.02	7	No	No	0	6	0	1
L:L:S30	R:R:N193	5.96	0	No	No	0	3	0	1
L:L:P32	R:R:Y178	13.91	0	No	No	0	2	0	1
L:L:I40	R:R:P29	3.39	0	No	No	0	3	0	1
L:L:R47	R:R:A23	2.77	2	Yes	No	0	3	0	1
L:L:E48	R:R:S28	7.19	0	No	No	0	5	0	1
L:L:L49	R:R:Y27	11.72	0	Yes	Yes	0	4	0	1
R:R:D24	R:R:D26	17.3	5	No	No	6	7	2	1
R:R:D24	R:R:Y27	5.75	5	No	Yes	6	4	2	1
R:R:E25	R:R:S28	8.62	0	No	No	2	5	2	1
R:R:D26	R:R:Y27	5.75	5	No	Yes	7	4	1	1
R:R:L32	R:R:R280	4.86	0	No	No	2	1	2	1
R:R:D288	R:R:K99	4.15	0	No	No	4	5	1	2
R:R:G102	R:R:S184	3.71	0	No	No	5	5	2	1
R:R:P180	R:R:Y178	13.91	0	No	No	3	2	2	1
R:R:V190	R:R:Y178	5.05	0	No	No	4	2	2	1
R:R:P185	R:R:S184	3.56	0	No	No	4	5	2	1
R:R:R199	R:R:Y188	16.46	1	Yes	No	4	4	1	1
R:R:E189	R:R:R199	3.49	1	Yes	Yes	5	4	2	1
R:R:A196	R:R:R269	2.77	0	No	Yes	1	2	2	1
R:R:R199	R:R:R203	6.4	1	Yes	Yes	4	5	1	1
R:R:M200	R:R:R269	4.96	0	No	Yes	3	2	2	1
R:R:H207	R:R:R203	3.39	1	No	Yes	6	5	2	1
R:R:L262	R:R:R203	14.58	1	Yes	Yes	6	5	2	1
R:R:H207	R:R:L262	6.43	1	No	Yes	6	6	2	2
R:R:L262	R:R:L287	4.15	1	Yes	No	6	4	2	1
R:R:D265	R:R:R269	9.53	1	Yes	Yes	5	2	1	1
R:R:D265	R:R:I283	4.2	1	Yes	No	5	4	1	2
R:R:E291	R:R:F295	10.49	0	No	Yes	6	7	1	2
L:L:H33	R:R:N181	2.55	0	No	No	0	3	0	1
R:R:S28	R:R:Y27	2.54	0	No	Yes	5	4	1	1
L:L:C9	R:R:P29	1.88	0	No	No	0	3	0	1
L:L:S1	R:R:T34	1.6	0	No	No	0	5	0	1
R:R:L287	R:R:V261	1.49	0	No	No	4	5	1	2
L:L:R26	R:R:N182	1.21	0	No	No	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IC0_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.75
Number of Linked Nodes	337
Number of Links	378
Number of Hubs	45
Number of Links mediated by Hubs	164
Number of Communities	14
Number of Nodes involved in Communities	65
Number of Links involved in Communities	79

Path Summary
Number Of Nodes in MetaPath	86
Number Of Links MetaPath	85
Number of Shortest Paths	86624
Length Of Smallest Path	3
Average Path Length	19.3719
Length of Longest Path	51
Minimum Path Strength	1.385
Average Path Strength	5.53252
Maximum Path Strength	16.435
Minimum Path Correlation	0.7
Average Path Correlation	0.948758
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.5
Average % Of Corr. Nodes	51.8216
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.8681
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• G protein-coupled chemoattractant receptor activity • molecular transducer activity • interleukin-8 receptor activity • C-X-C chemokine receptor activity • chemokine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cytokine receptor activity • immune receptor activity • C-C chemokine receptor activity • C-C chemokine binding • protein binding • binding • chemokine binding • cytokine binding • C-X-C chemokine binding • interleukin-8 binding • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cell chemotaxis • cellular response to stimulus • chemotaxis • dendritic cell chemotaxis • response to stimulus • response to external stimulus • leukocyte migration • dendritic cell migration • cellular response to chemical stimulus • taxis • immune system process
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cell chemotaxis • cellular response to stimulus • chemotaxis • dendritic cell chemotaxis • response to stimulus • response to external stimulus • leukocyte migration • dendritic cell migration • cellular response to chemical stimulus • taxis • immune system process • response to chemical • mononuclear cell migration • cell migration • cellular process • cell motility • leukocyte chemotaxis • locomotion • regulation of biological process • regulation of cellular process • cell surface receptor signaling pathway • signaling • signal transduction • cell communication • localization • import into cell • receptor internalization • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • immune response • neutrophil chemotaxis • neutrophil migration • granulocyte migration • granulocyte chemotaxis • myeloid leukocyte migration • G protein-coupled receptor signaling pathway • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle membrane
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • cell surface • membrane • plasma membrane • external side of plasma membrane • side of membrane • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle membrane • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • organelle membrane • secretory granule membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • Golgi apparatus • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • molecular function activator activity • signaling receptor activity • signaling receptor activator activity • cytokine receptor binding • chemokine activity • cytokine activity • signaling receptor regulator activity • chemokine receptor binding • receptor ligand activity • CXCR chemokine receptor binding • heparin binding • glycosaminoglycan binding • sulfur compound binding • interleukin-8 receptor binding • cell adhesion • regulation of cell adhesion • positive chemotaxis • chemotaxis • positive regulation of locomotion • regulation of response to external stimulus • positive regulation of positive chemotaxis • response to external stimulus • induction of positive chemotaxis • regulation of chemotaxis • positive regulation of chemotaxis • positive regulation of response to stimulus • regulation of positive chemotaxis • positive regulation of response to external stimulus • taxis • regulation of response to stimulus • regulation of locomotion • locomotion • import into cell • receptor internalization • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • blood vessel morphogenesis • tube development • angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • tube morphogenesis • anatomical structure formation involved in morphogenesis • blood vessel development • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of gene expression • regulation of macromolecule biosynthetic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • digestive system development • embryo development • digestive tract development • embryonic organ development • embryonic digestive tract development • neutrophil activation • cell activation • myeloid leukocyte activation • granulocyte activation • leukocyte activation • cell chemotaxis • neutrophil chemotaxis • neutrophil migration • granulocyte migration • granulocyte chemotaxis • myeloid leukocyte migration • leukocyte chemotaxis • biological process involved in interspecies interaction between organisms • entry of bacterium into host cell • regulation of entry of bacterium into host cell • symbiont entry into host • modulation by symbiont of entry into host • biological process involved in interaction with host • biological process involved in symbiotic interaction • regulation of biological process involved in symbiotic interaction • response to other organism • cellular response to lipopolysaccharide • cellular response to molecule of bacterial origin • response to lipopolysaccharide • response to biotic stimulus • cellular response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • regulation of cell motility • positive regulation of cell migration • positive regulation of neutrophil chemotaxis • regulation of immune system process • positive regulation of immune system process • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • positive regulation of granulocyte chemotaxis • regulation of neutrophil chemotaxis • regulation of neutrophil migration • regulation of granulocyte chemotaxis • positive regulation of cell motility • regulation of cell migration • positive regulation of leukocyte migration • positive regulation of neutrophil migration • calcium-mediated signaling • response to fibroblast growth factor • cellular response to growth factor stimulus • response to growth factor • cellular response to fibroblast growth factor stimulus • regulation of cell adhesion molecule production • negative regulation of cellular process • negative regulation of biological process • negative regulation of cell adhesion molecule production • cell adhesion molecule production • response to peptide • cellular response to tumor necrosis factor • response to cytokine • cellular response to cytokine stimulus • response to tumor necrosis factor • negative regulation of cell population proliferation • regulation of cell population proliferation • regulation of developmental process • regulation of vasculature development • positive regulation of developmental process • regulation of multicellular organismal process • regulation of anatomical structure morphogenesis • regulation of multicellular organismal development • positive regulation of angiogenesis • positive regulation of vasculature development • regulation of angiogenesis • positive regulation of multicellular organismal process • humoral immune response • defense response • immune response • defense response to symbiont • antimicrobial humoral response • antimicrobial humoral immune response mediated by antimicrobial peptide • defense response to other organism • response to stress • inflammatory response • regulation of signaling • negative regulation of signaling • negative regulation of response to stimulus • regulation of signal transduction • negative regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • regulation of cell communication • regulation of G protein-coupled receptor signaling pathway • regulation of single stranded viral RNA replication via double stranded DNA intermediate • RNA metabolic process • viral life cycle • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • regulation of RNA metabolic process • viral RNA genome replication • viral process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • nucleobase-containing compound biosynthetic process • single stranded viral RNA replication via double stranded DNA intermediate • nucleic acid metabolic process • regulation of viral life cycle • regulation of viral process • viral genome replication • regulation of viral genome replication • negative regulation of metabolic process • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • cellular response to interleukin-1 • response to interleukin-1 • cellular response to stress • response to endoplasmic reticulum stress
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • Interleukin 8-like chemokines
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • Interleukin 8-like chemokines
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P25024
Sequence	>8IC0_nogp_Chain_R P P A D E D Y S P C M L E T E T L N K Y V V I I A Y A L V F L L S L L G N S L V M L V I L Y S R V G R S V T D V Y L L N L A L A D L L F A L T L P I W A A S K V N G W I F G T F L C K V V S L L K E V N F Y S G I L L L A C I S V D R Y L A I V H A T R T L T Q K R H L V K F V C L G C W G L S M N L S L P F F L F R Q A Y H P N N S S P V C Y E V L G N D T A K W R M V L R I L P H T F G F I V P L F V M L F C Y G F T L R T L F K A H M G Q K H R A M R V I F A V V L I F L L C W L P Y N L V L L A D T L M R T Q V I Q E S C E R R N N I G R A L D A T E I L G F L H S C L N P I I Y A F I G Q N F R H G F L K I L A M Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IC0	A	Protein	Chemokine	CXCR1	Homo sapiens	Interleukin-8	-	Gi1/β1/γ2	3.41	2023-07-19	10.1038/s41467-023-39799-2
	8IC0 (No Gprot)	A	Protein	Chemokine	CXCR1	Homo sapiens	Interleukin-8	-		3.41	2023-07-19	10.1038/s41467-023-39799-2

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