psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:L5	R:R:Q279	5.32	No	No	0	0	1
2	L:L:R6	L:L:Y13	17.49	Yes	Yes	1	0	0
3	L:L:R6	R:R:G97	4.5	Yes	Yes	1	0	4
4	L:L:R6	R:R:F177	18.17	Yes	No	1	0	1
5	L:L:R6	R:R:S183	6.59	Yes	Yes	1	0	5
6	L:L:C7	L:L:R14	11.14	No	Yes	0	0	0
7	L:L:C16	L:L:C7	5.46	No	No	0	0	0
8	L:L:C7	R:R:P280	3.77	No	No	0	0	1
9	L:L:M8	R:R:W93	5.82	Yes	Yes	1	0	5
10	L:L:M8	R:R:P280	3.35	Yes	No	0	0	1
11	L:L:M8	R:R:Y285	7.18	Yes	No	1	0	4
12	L:L:M8	R:R:Y288	21.55	Yes	Yes	1	0	5
13	L:L:L9	L:L:R14	6.07	Yes	Yes	2	0	0
14	L:L:L9	R:R:F186	3.65	Yes	Yes	2	0	5
15	L:L:L9	R:R:V194	4.47	Yes	No	2	0	1
16	L:L:L9	R:R:Y197	3.52	Yes	Yes	2	0	6
17	L:L:G10	R:R:Q271	3.29	No	No	0	0	5
18	L:L:R11	R:R:H82	7.9	Yes	Yes	3	0	7
19	L:L:R11	R:R:D113	14.29	Yes	Yes	3	0	6
20	L:L:R11	R:R:Q117	10.51	Yes	Yes	0	0	7
21	L:L:R11	R:R:I292	3.76	Yes	No	0	0	5
22	L:L:R11	R:R:S295	5.27	Yes	No	0	0	7
23	L:L:R11	R:R:Y296	12.35	Yes	Yes	3	0	7
24	L:L:V12	R:R:F186	5.24	No	Yes	0	0	5
25	L:L:Y13	R:R:Q92	12.4	Yes	Yes	1	0	5
26	L:L:Y13	R:R:W93	12.54	Yes	Yes	1	0	5
27	L:L:Y13	R:R:G97	4.35	Yes	Yes	1	0	4
28	L:L:Y13	R:R:S183	10.17	Yes	Yes	1	0	5
29	L:L:Y13	R:R:Y285	8.94	Yes	No	1	0	4
30	L:L:P15	L:L:R14	4.32	No	Yes	0	0	0
31	L:L:R14	R:R:V194	5.23	Yes	No	2	0	1
32	L:L:P15	R:R:T189	6.99	No	No	0	0	5
33	L:L:W17	R:R:P191	9.46	No	No	0	0	1
34	R:R:I36	R:R:V32	4.61	No	No	0	5	5
35	R:R:D33	R:R:L37	5.43	No	No	0	5	6
36	R:R:C293	R:R:M40	3.24	No	No	0	5	5
37	R:R:I41	R:R:M86	4.37	No	Yes	0	7	8
38	R:R:I41	R:R:Y289	3.63	No	Yes	1	7	3
39	R:R:C293	R:R:I41	6.55	No	No	1	5	7
40	R:R:I44	R:R:S300	4.64	No	Yes	0	7	7
41	R:R:C45	R:R:L49	3.17	No	No	0	7	6
42	R:R:C45	R:R:I83	3.27	No	No	0	7	6
43	R:R:S300	R:R:T47	3.2	Yes	No	0	7	5
44	R:R:F304	R:R:T47	5.19	No	No	0	7	5
45	R:R:G48	R:R:S300	3.71	No	Yes	0	8	7
46	R:R:G51	R:R:V50	3.68	No	No	0	8	4
47	R:R:G51	R:R:P303	4.06	No	No	0	8	9
48	R:R:D79	R:R:N52	5.39	Yes	No	0	9	9
49	R:R:L80	R:R:N52	8.24	No	No	0	8	9
50	R:R:N52	R:R:P303	6.52	No	No	0	9	9
51	R:R:A76	R:R:I55	3.25	No	Yes	0	9	9
52	R:R:I55	R:R:P303	3.39	Yes	No	0	9	9
53	R:R:I55	R:R:Y306	4.84	Yes	No	0	9	9
54	R:R:I307	R:R:I55	5.89	No	Yes	0	6	9
55	R:R:F57	R:R:R61	8.55	No	No	0	4	4
56	R:R:D69	R:R:I59	4.2	No	No	0	8	7
57	R:R:C73	R:R:I59	8.18	No	No	0	5	7
58	R:R:P68	R:R:T66	6.99	No	No	0	7	7
59	R:R:D69	R:R:T66	10.12	No	No	0	8	7
60	R:R:P68	R:R:V67	3.53	No	No	0	7	6
61	R:R:D130	R:R:V67	4.38	No	No	0	8	6
62	R:R:T150	R:R:V67	12.69	No	No	0	7	6
63	R:R:I70	R:R:T150	4.56	No	No	0	6	7
64	R:R:I151	R:R:I70	4.42	No	No	0	3	6
65	R:R:V126	R:R:Y71	5.05	No	Yes	0	7	7
66	R:R:M127	R:R:Y71	8.38	No	Yes	0	8	7
67	R:R:D130	R:R:Y71	13.79	No	Yes	0	8	7
68	R:R:T150	R:R:Y71	4.99	No	Yes	0	7	7
69	R:R:N154	R:R:Y71	6.98	No	Yes	0	7	7
70	R:R:I72	R:R:Y306	19.34	No	No	0	8	9
71	R:R:I123	R:R:N74	11.33	No	No	0	8	9
72	R:R:N154	R:R:N74	9.54	No	No	0	7	9
73	R:R:N74	R:R:W158	9.04	No	No	0	9	9
74	R:R:D79	R:R:L75	9.5	Yes	No	0	9	9
75	R:R:I123	R:R:L75	5.71	No	No	0	8	9
76	R:R:L75	R:R:M124	5.65	No	No	0	9	8
77	R:R:C120	R:R:D79	4.67	No	Yes	0	9	9
78	R:R:D79	R:R:S299	8.83	Yes	Yes	0	9	9
79	R:R:N116	R:R:V81	8.87	No	No	0	8	7
80	R:R:D113	R:R:H82	7.56	Yes	Yes	3	6	7
81	R:R:H82	R:R:N116	5.1	Yes	No	0	7	8
82	R:R:H82	R:R:Y296	16.33	Yes	Yes	3	7	7
83	R:R:H82	R:R:S299	4.18	Yes	Yes	0	7	9
84	R:R:I83	R:R:S299	3.1	No	Yes	0	6	9
85	R:R:I83	R:R:S300	4.64	No	Yes	0	6	7
86	R:R:M86	R:R:P87	3.35	Yes	No	0	8	8
87	R:R:I90	R:R:M86	5.83	No	Yes	0	7	8
88	R:R:M86	R:R:Y296	26.34	Yes	Yes	0	8	7
89	R:R:F101	R:R:F88	8.57	Yes	No	0	7	6
90	R:R:F88	R:R:I109	6.28	No	No	0	6	6
91	R:R:I109	R:R:L89	5.71	No	No	0	6	6
92	R:R:D113	R:R:L89	5.43	Yes	No	0	6	6
93	R:R:I90	R:R:Y289	3.63	No	Yes	0	7	3
94	R:R:H91	R:R:W99	9.52	No	Yes	1	4	8
95	R:R:H91	R:R:V100	6.92	No	No	1	4	4
96	R:R:F101	R:R:H91	13.58	Yes	No	1	7	4
97	R:R:Q92	R:R:W99	8.76	Yes	Yes	1	5	8
98	R:R:Q92	R:R:S183	4.33	Yes	Yes	1	5	5
99	R:R:C184	R:R:Q92	6.1	No	Yes	1	9	5
100	R:R:W93	R:R:Y285	9.65	Yes	No	1	5	4
101	R:R:W93	R:R:Y288	5.79	Yes	Yes	1	5	5
102	R:R:W93	R:R:Y289	7.72	Yes	Yes	1	5	3
103	R:R:E98	R:R:R95	8.14	No	No	0	4	4
104	R:R:E98	R:R:V100	4.28	No	No	0	4	4
105	R:R:F101	R:R:W99	9.02	Yes	Yes	1	7	8
106	R:R:C106	R:R:W99	9.14	No	Yes	1	9	8
107	R:R:C184	R:R:W99	14.37	No	Yes	1	9	8
108	R:R:F101	R:R:V100	5.24	Yes	No	1	7	4
109	R:R:G103	R:R:P104	4.06	No	No	0	3	1
110	R:R:C106	R:R:V174	3.42	No	No	0	9	5
111	R:R:C106	R:R:C184	5.46	No	No	1	9	9
112	R:R:S172	R:R:T107	9.59	No	No	0	5	7
113	R:R:I108	R:R:W169	3.52	No	No	0	5	5
114	R:R:T110	R:R:V168	3.17	No	Yes	0	5	5
115	R:R:S172	R:R:T110	9.59	No	No	0	5	5
116	R:R:F186	R:R:T110	3.89	Yes	No	0	5	5
117	R:R:S111	R:R:V168	6.46	No	Yes	0	6	5
118	R:R:S111	R:R:W169	23.47	No	No	0	6	5
119	R:R:D113	R:R:Y296	5.75	Yes	Yes	3	6	7
120	R:R:F118	R:R:T114	5.19	Yes	No	0	7	5
121	R:R:T114	R:R:V168	9.52	No	Yes	0	5	5
122	R:R:C115	R:R:F162	4.19	No	No	0	6	3
123	R:R:F118	R:R:Q117	3.51	Yes	Yes	0	7	7
124	R:R:L201	R:R:Q117	5.32	No	Yes	0	5	7
125	R:R:Q117	R:R:T205	15.59	Yes	No	0	7	5
126	R:R:F118	R:R:Y200	8.25	Yes	No	0	7	4
127	R:R:A119	R:R:W158	7.78	No	No	4	7	9
128	R:R:A119	R:R:S161	3.42	No	No	4	7	8
129	R:R:S121	R:R:T205	3.2	No	No	0	7	5
130	R:R:A122	R:R:L157	4.73	No	No	0	5	7
131	R:R:M124	R:R:N302	4.21	No	No	0	8	9
132	R:R:P209	R:R:T125	3.5	No	No	0	9	7
133	R:R:L212	R:R:T125	4.42	No	No	0	6	7
134	R:R:I213	R:R:S128	9.29	No	No	0	8	9
135	R:R:C216	R:R:S128	3.44	No	No	0	8	9
136	R:R:D130	R:R:R145	7.15	No	No	0	8	7
137	R:R:L135	R:R:R131	3.64	No	No	0	8	9
138	R:R:R131	R:R:V253	6.54	No	No	0	9	7
139	R:R:F133	R:R:Y132	8.25	Yes	Yes	5	4	8
140	R:R:V136	R:R:Y132	12.62	No	Yes	0	7	8
141	R:R:Q137	R:R:Y132	7.89	Yes	Yes	5	7	8
142	R:R:C216	R:R:Y132	4.03	No	Yes	0	8	8
143	R:R:L219	R:R:Y132	8.21	No	Yes	0	4	8
144	R:R:I220	R:R:Y132	3.63	No	Yes	0	8	8
145	R:R:F133	R:R:Q137	4.68	Yes	Yes	5	4	7
146	R:R:F133	R:R:L141	10.96	Yes	No	0	4	5
147	R:R:I220	R:R:L135	4.28	No	No	0	8	8
148	R:R:V136	R:R:Y223	8.83	No	No	0	7	5
149	R:R:Q137	R:R:R140	14.02	Yes	No	0	7	5
150	R:R:F139	R:R:P138	13	No	No	0	5	8
151	R:R:L141	R:R:W144	10.25	No	No	0	5	1
152	R:R:K149	R:R:W144	3.48	Yes	No	0	4	1
153	R:R:K149	R:R:T146	4.5	Yes	No	0	4	6
154	R:R:I151	R:R:R147	3.76	No	No	0	3	3
155	R:R:K149	R:R:Y148	5.97	Yes	No	0	4	4
156	R:R:R152	R:R:Y148	22.64	No	No	0	3	4
157	R:R:S161	R:R:W158	4.94	No	No	4	8	9
158	R:R:V168	R:R:Y197	6.31	Yes	Yes	0	5	6
159	R:R:V170	R:R:Y171	11.36	No	No	0	4	5
160	R:R:L188	R:R:Y171	9.38	No	No	0	6	5
161	R:R:D187	R:R:K173	9.68	No	No	0	4	3
162	R:R:E182	R:R:V174	5.7	No	No	0	5	5
163	R:R:F177	R:R:I175	6.28	No	No	0	1	1
164	R:R:A185	R:R:I175	4.87	No	No	0	4	1
165	R:R:F177	R:R:S183	6.61	No	Yes	1	1	5
166	R:R:F186	R:R:L188	4.87	Yes	No	2	5	6
167	R:R:F186	R:R:Y197	10.32	Yes	Yes	2	5	6
168	R:R:L188	R:R:Y197	4.69	No	Yes	2	6	6
169	R:R:D193	R:R:S190	8.83	No	No	0	1	2
170	R:R:D192	R:R:W196	8.93	No	No	0	3	4
171	R:R:L195	R:R:L199	5.54	No	No	0	3	4
172	R:R:L195	R:R:L275	4.15	No	No	0	3	5
173	R:R:L201	R:R:Y197	3.52	No	Yes	0	5	6
174	R:R:F207	R:R:T202	6.49	No	No	0	4	5
175	R:R:H268	R:R:T202	6.85	Yes	No	0	8	5
176	R:R:H268	R:R:T205	9.58	Yes	No	0	8	5
177	R:R:F206	R:R:F207	8.57	Yes	No	0	8	4
178	R:R:F206	R:R:L210	8.53	Yes	Yes	6	8	7
179	R:R:F206	R:R:F260	6.43	Yes	No	6	8	9
180	R:R:A264	R:R:F206	4.16	No	Yes	0	8	8
181	R:R:A265	R:R:F206	4.16	No	Yes	0	5	8
182	R:R:F206	R:R:H268	15.84	Yes	Yes	0	8	8
183	R:R:F208	R:R:P209	4.33	No	No	0	6	9
184	R:R:F208	R:R:L212	4.87	No	No	0	6	6
185	R:R:L210	R:R:P211	3.28	Yes	No	0	7	3
186	R:R:F260	R:R:L210	3.65	No	Yes	6	9	7
187	R:R:L214	R:R:V257	4.47	No	No	0	4	8
188	R:R:I218	R:R:Y217	3.63	No	No	0	3	9
189	R:R:V253	R:R:Y217	3.79	No	No	0	7	9
190	R:R:L254	R:R:Y217	11.72	No	No	0	4	9
191	R:R:M227	R:R:Y223	14.37	No	No	0	6	5
192	R:R:T224	R:R:V246	6.35	No	No	0	8	6
193	R:R:Q229	R:R:W225	17.52	No	No	0	4	4
194	R:R:Q229	R:R:Y228	3.38	No	No	0	4	4
195	R:R:K243	R:R:Y228	5.97	No	No	0	1	4
196	R:R:V246	R:R:Y228	5.05	No	No	0	6	4
197	R:R:C236	R:R:K232	3.23	No	No	0	2	3
198	R:R:C237	R:R:N238	7.87	No	No	0	3	5
199	R:R:N238	R:R:P239	4.89	No	No	0	5	4
200	R:R:P242	R:R:V241	3.53	No	No	0	4	3
201	R:R:L249	R:R:T250	4.42	No	No	0	7	6
202	R:R:K251	R:R:L309	8.46	No	No	0	6	6
203	R:R:M252	R:R:Y256	4.79	No	Yes	0	8	8
204	R:R:L305	R:R:V255	4.47	No	No	0	8	6
205	R:R:L309	R:R:V255	4.47	No	No	0	6	6
206	R:R:N302	R:R:Y256	5.81	No	Yes	0	9	8
207	R:R:L305	R:R:Y256	8.21	No	Yes	0	8	8
208	R:R:I301	R:R:V259	9.22	No	No	0	6	6
209	R:R:A297	R:R:S263	3.42	No	No	0	5	8
210	R:R:S263	R:R:S298	6.52	No	No	0	8	9
211	R:R:H268	R:R:Y267	10.89	Yes	Yes	0	8	7
212	R:R:Q271	R:R:Y267	19.16	No	Yes	0	5	7
213	R:R:S291	R:R:Y267	3.82	No	Yes	0	7	7
214	R:R:I292	R:R:Y267	3.63	No	Yes	0	5	7
215	R:R:I270	R:R:Y288	3.63	No	Yes	0	4	5
216	R:R:I270	R:R:S291	4.64	No	No	0	4	7
217	R:R:Q271	R:R:Y288	13.53	No	Yes	0	5	5
218	R:R:F284	R:R:N274	7.25	Yes	No	0	4	4
219	R:R:I292	R:R:Y288	8.46	No	Yes	0	5	5
220	R:R:C293	R:R:Y289	9.41	No	Yes	1	5	3
221	R:R:I301	R:R:L305	4.28	No	No	0	6	8
222	R:R:F313	R:R:Y306	24.76	No	No	0	9	9
223	R:R:G311	R:R:S310	3.71	No	No	0	4	8
224	R:R:F313	R:R:S310	5.28	No	No	0	9	8
225	R:R:G311	R:R:N312	3.39	No	No	0	4	6
226	R:R:F313	R:R:R316	14.97	No	No	0	9	5
227	R:R:R131	R:R:Y256	3.09	No	Yes	0	9	8
228	R:R:I261	R:R:V257	3.07	No	No	0	5	8
229	L:L:C16	R:R:Q279	3.05	No	No	0	0	1
230	R:R:I213	R:R:T125	3.04	No	No	0	8	7
231	R:R:F88	R:R:G85	3.01	No	No	0	6	7
232	R:R:L80	R:R:V84	2.98	No	No	0	8	4
233	R:R:L157	R:R:V126	2.98	No	No	0	7	7
234	R:R:L219	R:R:V215	2.98	No	No	0	4	4
235	R:R:L254	R:R:V258	2.98	No	No	0	4	5
236	R:R:L262	R:R:V258	2.98	No	No	0	6	5
237	R:R:L282	R:R:V286	2.98	No	No	0	1	1
238	L:L:L9	R:R:T198	2.95	Yes	No	0	0	5
239	R:R:I59	R:R:K65	2.91	No	No	0	7	6
240	R:R:I307	R:R:L54	2.85	No	No	0	6	6
241	R:R:I108	R:R:L112	2.85	No	No	0	5	6
242	R:R:I151	R:R:L155	2.85	No	No	0	3	4
243	R:R:I261	R:R:L210	2.85	No	Yes	0	5	7
244	R:R:I307	R:R:L308	2.85	No	No	0	6	7
245	R:R:G102	R:R:W99	2.81	No	Yes	0	8	8
246	R:R:M227	R:R:N231	2.8	No	No	0	6	4
247	R:R:M277	R:R:N274	2.8	No	No	0	4	4
248	R:R:L317	R:R:L54	2.77	No	No	7	7	6
249	R:R:A134	R:R:R145	2.77	No	No	0	8	7
250	R:R:D179	R:R:K178	2.77	No	No	0	2	1
251	R:R:K232	R:R:Q229	2.71	No	No	0	3	4
252	R:R:E182	R:R:K176	2.7	No	No	0	5	2
253	R:R:F133	R:R:V129	2.62	Yes	No	0	4	6
254	R:R:F284	R:R:V273	2.62	Yes	No	0	4	4
255	R:R:F118	R:R:T204	2.59	Yes	No	0	7	4
256	L:L:M8	R:R:F284	2.49	Yes	Yes	0	0	4
257	R:R:K243	R:R:R235	2.48	No	No	0	1	4
258	R:R:F101	R:R:L105	2.44	Yes	No	0	7	6
259	R:R:F118	R:R:L164	2.44	Yes	No	0	7	5
260	R:R:F207	R:R:L272	2.44	No	No	0	4	6
261	L:L:W17	R:R:T189	2.43	No	No	0	0	5
262	R:R:L317	R:R:R61	2.43	No	No	0	7	4
263	R:R:D187	R:R:Y171	2.3	No	No	0	4	5
264	R:R:G96	R:R:G97	2.11	No	Yes	0	4	4
265	R:R:G102	R:R:G103	2.11	No	No	0	8	3
266	R:R:C45	R:R:G42	1.96	No	No	0	7	5
267	R:R:A159	R:R:G156	1.95	No	No	0	3	4
268	R:R:A265	R:R:P266	1.87	No	No	0	5	9
269	R:R:G97	R:R:V181	1.84	Yes	No	0	4	2
270	R:R:A78	R:R:C120	1.81	No	No	0	8	9
271	R:R:A165	R:R:C115	1.81	No	No	0	7	6
272	R:R:P191	R:R:S190	1.78	No	No	0	1	2
273	R:R:C115	R:R:S161	1.72	No	No	0	6	8
274	R:R:C73	R:R:V77	1.71	No	No	0	5	6
275	R:R:G156	R:R:L155	1.71	No	No	0	4	4
276	R:R:G287	R:R:L290	1.71	No	No	0	5	5
277	R:R:A76	R:R:V56	1.7	No	No	0	9	7
278	R:R:A283	R:R:T281	1.68	No	No	0	3	2
279	R:R:L37	R:R:P38	1.64	No	No	0	6	6
280	R:R:L166	R:R:P167	1.64	No	No	0	4	7
281	R:R:C222	R:R:I218	1.64	No	No	0	3	3
282	R:R:L294	R:R:P266	1.64	No	No	0	7	9
283	R:R:S298	R:R:S299	1.63	No	Yes	0	9	9
284	R:R:T34	R:R:V35	1.59	No	No	0	5	5
285	R:R:T250	R:R:V253	1.59	No	No	0	6	7
286	R:R:P138	R:R:Q137	1.58	No	Yes	0	8	7
287	R:R:T224	R:R:T250	1.57	No	No	0	8	6
288	R:R:I36	R:R:V35	1.54	No	No	0	5	5
289	R:R:I60	R:R:V56	1.54	No	No	0	3	7
290	R:R:I153	R:R:V126	1.54	No	No	0	6	7
291	R:R:I270	R:R:V269	1.54	No	No	0	4	6
292	R:R:K65	R:R:S62	1.53	No	No	0	6	5
293	R:R:I43	R:R:T47	1.52	No	No	0	5	5
294	R:R:K64	R:R:T66	1.5	No	No	0	7	7
295	R:R:L275	R:R:V194	1.49	No	No	0	5	1
296	R:R:L221	R:R:V246	1.49	No	No	0	5	6
297	R:R:L290	R:R:V286	1.49	No	No	0	5	1
298	R:R:L54	R:R:T58	1.47	No	No	7	6	7
299	R:R:L317	R:R:T58	1.47	No	No	7	7	7
300	R:R:D179	R:R:V181	1.46	No	No	0	2	2
301	R:R:I53	R:R:L80	1.43	No	No	0	3	8
302	R:R:I163	R:R:L166	1.43	No	No	0	4	4
303	R:R:I203	R:R:L199	1.43	No	No	0	4	4
304	R:R:L290	R:R:M40	1.41	No	No	0	5	5
305	R:R:L254	R:R:M247	1.41	No	No	0	4	5
306	R:R:K315	R:R:N312	1.4	No	No	0	5	6
307	R:R:M227	R:R:Q230	1.36	No	No	0	6	4
308	R:R:K248	R:R:Q244	1.36	No	No	0	7	3
309	R:R:D192	R:R:D193	1.33	No	No	0	3	1
310	R:R:F284	R:R:T281	1.3	Yes	No	0	4	2
311	R:R:R145	R:R:T142	1.29	No	No	0	7	3
312	R:R:K149	R:R:R143	1.24	Yes	No	0	4	4
313	R:R:L37	R:R:Y289	1.17	No	Yes	0	6	3
314	R:R:L166	R:R:W169	1.14	No	No	0	4	5
315	R:R:E226	R:R:W225	1.09	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:R6	11.6875	4	1	0
2	L:L:M8	8.078	5	1	0
3	L:L:L9	4.132	5	2	0
4	L:L:R11	9.01333	6	3	0
5	L:L:Y13	10.9817	6	1	0
6	L:L:R14	6.69	4	2	0
7	R:R:I55	4.3425	4	0	9
8	R:R:Y71	7.838	5	0	7
9	R:R:D79	7.0975	4	0	9
10	R:R:H82	8.214	5	3	7
11	R:R:M86	9.9725	4	0	8
12	R:R:Q92	7.8975	4	1	5
13	R:R:W93	8.304	5	1	5
14	R:R:G97	3.2	4	1	4
15	R:R:W99	8.93667	6	1	8
16	R:R:F101	7.77	5	1	7
17	R:R:D113	8.2575	4	3	6
18	R:R:Q117	8.7325	4	0	7
19	R:R:F118	4.396	5	0	7
20	R:R:Y132	7.43833	6	5	8
21	R:R:F133	6.6275	4	5	4
22	R:R:Q137	7.0425	4	5	7
23	R:R:K149	3.7975	4	0	4
24	R:R:V168	6.365	4	0	5
25	R:R:S183	6.925	4	1	5
26	R:R:F186	5.594	5	2	5
27	R:R:Y197	5.672	5	2	6
28	R:R:F206	7.94833	6	6	8
29	R:R:L210	4.5775	4	6	7
30	R:R:Y256	5.475	4	0	8
31	R:R:Y267	9.375	4	0	7
32	R:R:H268	10.79	4	0	8
33	R:R:F284	3.415	4	0	4
34	R:R:Y288	10.592	5	1	5
35	R:R:Y289	5.112	5	1	3
36	R:R:Y296	15.1925	4	3	7
37	R:R:S299	4.435	4	0	9
38	R:R:S300	4.0475	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C7	R:R:P280	17.4812	3.77	No	No	0	0	1
2	L:L:M8	R:R:P280	18.4927	3.35	Yes	No	0	0	1
3	L:L:Y13	R:R:W93	28.0411	12.54	Yes	Yes	1	0	5
4	L:L:C7	L:L:R14	13.6871	11.14	No	Yes	0	0	0
5	L:L:M8	R:R:Y288	10.8489	21.55	Yes	Yes	1	0	5
6	L:L:L9	L:L:R14	15.184	6.07	Yes	Yes	2	0	0
7	L:L:L9	R:R:Y197	16.5771	3.52	Yes	Yes	2	0	6
8	R:R:I292	R:R:Y288	31.4499	8.46	No	Yes	0	5	5
9	L:L:R11	R:R:I292	41.1946	3.76	Yes	No	0	0	5
10	L:L:R11	R:R:H82	77.7984	7.9	Yes	Yes	3	0	7
11	R:R:L201	R:R:Y197	31.6907	3.52	No	Yes	0	5	6
12	R:R:L201	R:R:Q117	32.554	5.32	No	Yes	0	5	7
13	L:L:Y13	R:R:Q92	16.6031	12.4	Yes	Yes	1	0	5
14	L:L:P15	L:L:R14	10.2227	4.32	No	Yes	0	0	0
15	R:R:H82	R:R:S299	100	4.18	Yes	Yes	0	7	9
16	R:R:I83	R:R:S299	11.853	3.1	No	Yes	0	6	9
17	R:R:D79	R:R:S299	98.0288	8.83	Yes	Yes	0	9	9
18	R:R:D79	R:R:N52	29.2823	5.39	Yes	No	0	9	9
19	R:R:N52	R:R:P303	25.1028	6.52	No	No	0	9	9
20	R:R:I55	R:R:P303	21.8904	3.39	Yes	No	0	9	9
21	R:R:D79	R:R:L75	89.3253	9.5	Yes	No	0	9	9
22	R:R:I123	R:R:L75	48.4012	5.71	No	No	0	8	9
23	R:R:I123	R:R:N74	47.5157	11.33	No	No	0	8	9
24	R:R:N154	R:R:N74	41.1093	9.54	No	No	0	7	9
25	R:R:N154	R:R:Y71	40.1645	6.98	No	Yes	0	7	7
26	R:R:D130	R:R:Y71	15.6101	13.79	No	Yes	0	8	7
27	R:R:D130	R:R:V67	11.3268	4.38	No	No	0	8	6
28	R:R:P68	R:R:V67	20.3379	3.53	No	No	0	7	6
29	R:R:P68	R:R:T66	18.1074	6.99	No	No	0	7	7
30	R:R:D69	R:R:T66	13.6241	10.12	No	No	0	8	7
31	R:R:T150	R:R:Y71	18.9336	4.99	No	Yes	0	7	7
32	R:R:T150	R:R:V67	11.438	12.69	No	No	0	7	6
33	R:R:D69	R:R:I59	11.3713	4.2	No	No	0	8	7
34	R:R:L75	R:R:M124	61.9845	5.65	No	No	0	9	8
35	R:R:Q92	R:R:W99	11.2638	8.76	Yes	Yes	1	5	8
36	R:R:F101	R:R:F88	12.3458	8.57	Yes	No	0	7	6
37	R:R:D113	R:R:L89	15.6397	5.43	Yes	No	0	6	6
38	R:R:I109	R:R:L89	14.7023	5.71	No	No	0	6	6
39	R:R:V168	R:R:Y197	13.65	6.31	Yes	Yes	0	5	6
40	R:R:S111	R:R:V168	16.4919	6.46	No	Yes	0	6	5
41	R:R:S111	R:R:W169	14.1576	23.47	No	No	0	6	5
42	R:R:T114	R:R:V168	10.8711	9.52	No	Yes	0	5	5
43	R:R:F118	R:R:T114	11.7418	5.19	Yes	No	0	7	5
44	R:R:F118	R:R:Q117	15.536	3.51	Yes	Yes	0	7	7
45	R:R:Q117	R:R:T205	17.2774	15.59	Yes	No	0	7	5
46	R:R:M124	R:R:N302	61.2249	4.21	No	No	0	8	9
47	R:R:N302	R:R:Y256	60.458	5.81	No	Yes	0	9	8
48	R:R:R131	R:R:Y256	54.0517	3.09	No	Yes	0	9	8
49	R:R:L135	R:R:R131	34.2843	3.64	No	No	0	8	9
50	R:R:I220	R:R:L135	33.2876	4.28	No	No	0	8	8
51	R:R:I220	R:R:Y132	32.2835	3.63	No	Yes	0	8	8
52	R:R:R131	R:R:V253	23.7949	6.54	No	No	0	9	7
53	R:R:F133	R:R:Y132	10.5673	8.25	Yes	Yes	5	4	8
54	R:R:H268	R:R:Y267	20.8529	10.89	Yes	Yes	0	8	7
55	R:R:I292	R:R:Y267	18.804	3.63	No	Yes	0	5	7
56	R:R:F206	R:R:H268	26.144	15.84	Yes	Yes	0	8	8
57	R:R:F206	R:R:L210	10.2042	8.53	Yes	Yes	6	8	7
58	R:R:T250	R:R:V253	15.0654	1.59	No	No	0	6	7
59	R:R:T224	R:R:T250	12.783	1.57	No	No	0	8	6
60	R:R:T224	R:R:V246	11.6751	6.35	No	No	0	8	6
61	R:R:W93	R:R:Y288	23.2947	5.79	Yes	Yes	1	5	5
62	L:L:R11	R:R:Q117	56.0673	10.51	Yes	Yes	0	0	7
63	R:R:M86	R:R:Y296	14.1057	26.34	Yes	Yes	0	8	7
64	R:R:F88	R:R:I109	13.7315	6.28	No	No	0	6	6
65	R:R:H268	R:R:T205	15.8768	9.58	Yes	No	0	8	5
66	R:R:H82	R:R:Y296	10.8748	16.33	Yes	Yes	3	7	7
67	R:R:D113	R:R:H82	11.5306	7.56	Yes	Yes	3	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:L5	R:R:Q279	5.32	0	No	No	0	1	0	1
L:L:R6	R:R:G97	4.5	1	Yes	Yes	0	4	0	1
L:L:R6	R:R:F177	18.17	1	Yes	No	0	1	0	1
L:L:R6	R:R:S183	6.59	1	Yes	Yes	0	5	0	1
L:L:C7	R:R:P280	3.77	0	No	No	0	1	0	1
L:L:M8	R:R:W93	5.82	1	Yes	Yes	0	5	0	1
L:L:M8	R:R:P280	3.35	1	Yes	No	0	1	0	1
L:L:M8	R:R:Y285	7.18	1	Yes	No	0	4	0	1
L:L:M8	R:R:Y288	21.55	1	Yes	Yes	0	5	0	1
L:L:L9	R:R:F186	3.65	2	Yes	Yes	0	5	0	1
L:L:L9	R:R:V194	4.47	2	Yes	No	0	1	0	1
L:L:L9	R:R:Y197	3.52	2	Yes	Yes	0	6	0	1
L:L:G10	R:R:Q271	3.29	0	No	No	0	5	0	1
L:L:R11	R:R:H82	7.9	3	Yes	Yes	0	7	0	1
L:L:R11	R:R:D113	14.29	3	Yes	Yes	0	6	0	1
L:L:R11	R:R:Q117	10.51	3	Yes	Yes	0	7	0	1
L:L:R11	R:R:I292	3.76	3	Yes	No	0	5	0	1
L:L:R11	R:R:S295	5.27	3	Yes	No	0	7	0	1
L:L:R11	R:R:Y296	12.35	3	Yes	Yes	0	7	0	1
L:L:V12	R:R:F186	5.24	0	No	Yes	0	5	0	1
L:L:Y13	R:R:Q92	12.4	1	Yes	Yes	0	5	0	1
L:L:Y13	R:R:W93	12.54	1	Yes	Yes	0	5	0	1
L:L:Y13	R:R:G97	4.35	1	Yes	Yes	0	4	0	1
L:L:Y13	R:R:S183	10.17	1	Yes	Yes	0	5	0	1
L:L:Y13	R:R:Y285	8.94	1	Yes	No	0	4	0	1
L:L:R14	R:R:V194	5.23	2	Yes	No	0	1	0	1
L:L:P15	R:R:T189	6.99	0	No	No	0	5	0	1
L:L:W17	R:R:P191	9.46	0	No	No	0	1	0	1
R:R:D113	R:R:H82	7.56	3	Yes	Yes	6	7	1	1
R:R:H82	R:R:N116	5.1	3	Yes	No	7	8	1	2
R:R:H82	R:R:Y296	16.33	3	Yes	Yes	7	7	1	1
R:R:H82	R:R:S299	4.18	3	Yes	Yes	7	9	1	2
R:R:M86	R:R:Y296	26.34	0	Yes	Yes	8	7	2	1
R:R:D113	R:R:L89	5.43	3	Yes	No	6	6	1	2
R:R:Q92	R:R:W99	8.76	1	Yes	Yes	5	8	1	2
R:R:Q92	R:R:S183	4.33	1	Yes	Yes	5	5	1	1
R:R:C184	R:R:Q92	6.1	1	No	Yes	9	5	2	1
R:R:W93	R:R:Y285	9.65	1	Yes	No	5	4	1	1
R:R:W93	R:R:Y288	5.79	1	Yes	Yes	5	5	1	1
R:R:W93	R:R:Y289	7.72	1	Yes	Yes	5	3	1	2
R:R:C184	R:R:W99	14.37	1	No	Yes	9	8	2	2
R:R:T110	R:R:V168	3.17	0	No	Yes	5	5	2	2
R:R:F186	R:R:T110	3.89	2	Yes	No	5	5	1	2
R:R:D113	R:R:Y296	5.75	3	Yes	Yes	6	7	1	1
R:R:F118	R:R:Q117	3.51	0	Yes	Yes	7	7	2	1
R:R:L201	R:R:Q117	5.32	0	No	Yes	5	7	2	1
R:R:Q117	R:R:T205	15.59	0	Yes	No	7	5	1	2
R:R:V168	R:R:Y197	6.31	0	Yes	Yes	5	6	2	1
R:R:F177	R:R:I175	6.28	1	No	No	1	1	1	2
R:R:F177	R:R:S183	6.61	1	No	Yes	1	5	1	1
R:R:F186	R:R:L188	4.87	2	Yes	No	5	6	1	2
R:R:F186	R:R:Y197	10.32	2	Yes	Yes	5	6	1	1
R:R:L188	R:R:Y197	4.69	2	No	Yes	6	6	2	1
R:R:L201	R:R:Y197	3.52	0	No	Yes	5	6	2	1
R:R:Q271	R:R:Y267	19.16	0	No	Yes	5	7	1	2
R:R:I292	R:R:Y267	3.63	0	No	Yes	5	7	1	2
R:R:I270	R:R:Y288	3.63	0	No	Yes	4	5	2	1
R:R:Q271	R:R:Y288	13.53	0	No	Yes	5	5	1	1
R:R:F284	R:R:N274	7.25	0	Yes	No	4	4	1	2
R:R:I292	R:R:Y288	8.46	0	No	Yes	5	5	1	1
L:L:C16	R:R:Q279	3.05	0	No	No	0	1	0	1
L:L:L9	R:R:T198	2.95	2	Yes	No	0	5	0	1
R:R:F284	R:R:V273	2.62	0	Yes	No	4	4	1	2
L:L:M8	R:R:F284	2.49	1	Yes	Yes	0	4	0	1
L:L:W17	R:R:T189	2.43	0	No	No	0	5	0	1
R:R:G96	R:R:G97	2.11	0	No	Yes	4	4	2	1
R:R:G97	R:R:V181	1.84	1	Yes	No	4	2	1	2
R:R:P191	R:R:S190	1.78	0	No	No	1	2	1	2
R:R:L275	R:R:V194	1.49	0	No	No	5	1	2	1
R:R:F284	R:R:T281	1.3	0	Yes	No	4	2	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8WST_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.1
Number of Linked Nodes	286
Number of Links	315
Number of Hubs	38
Number of Links mediated by Hubs	136
Number of Communities	7
Number of Nodes involved in Communities	41
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	68
Number Of Links MetaPath	67
Number of Shortest Paths	54802
Length Of Smallest Path	3
Average Path Length	13.8232
Length of Longest Path	31
Minimum Path Strength	1.285
Average Path Strength	6.88308
Maximum Path Strength	22.05
Minimum Path Correlation	0.7
Average Path Correlation	0.942939
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	62.5025
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.6145
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q969V1
Sequence	>8WST_nogp_Chain_R V V D T V I L P S M I G I I C S T G L V G N I L I V F T I I R S R K K T V P D I Y I C N L A V A D L V H I V G M P F L I H Q W A R G G E W V F G G P L C T I I T S L D T C N Q F A C S A I M T V M S V D R Y F A L V Q P F R L T R W R T R Y K T I R I N L G L W A A S F I L A L P V W V Y S K V I K F K D G V E S C A F D L T S P D D V L W Y T L Y L T I T T F F F P L P L I L V C Y I L I L C Y T W E M Y Q Q N K D A R C C N P S V P K Q R V M K L T K M V L V Y V V V F I L S A A P Y H V I Q L V N L Q M E Q P T L A F Y V G Y Y L S I C L S Y A S S S I N P F L Y I L L S G N F Q K R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8WST	A	Peptide	Melanin Concentrating Hormone	MCH2	Homo sapiens	Pro-MCH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.4	2024-06-19	doi.org/10.1038/s41421-024-00679-8
	8WST (No Gprot)	A	Peptide	Melanin Concentrating Hormone	MCH2	Homo sapiens	Pro-MCH	-		2.4	2024-06-19	doi.org/10.1038/s41421-024-00679-8

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Download 8WST_nogp.zip

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