Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1P:P:V74 5.83254138
2P:P:L81 6.795406
3P:P:Q85 6.4275407
4P:P:I98 3.6475403
5P:P:F114 4.625406
6P:P:D117 6.2425418
7P:P:Y121 8.158517
8P:P:S122 6.04456
9P:P:F126 6.41571754
10P:P:F129 4.4025407
11P:P:R134 6.9365139
12P:P:R142 4.96507
13P:P:E148 6.14406
14P:P:F162 7.8675406
15P:P:W164 6.952556
16P:P:L166 5.3975415
17P:P:V172 3.765405
18P:P:C187 3.444148
19P:P:K201 10.248518
20P:P:W203 9.7375415
21P:P:F204 7.56518
22P:P:E219 4.415405
23P:P:L220 5.5625433
24P:P:Y222 9.73407
25P:P:R225 9.14533
26P:P:W230 11.075406
27P:P:Y232 6.23507
28P:P:F239 11.312568
29P:P:Y240 8.0775408
30P:P:Y251 8.205404
31P:P:F253 5.484525
32P:P:R254 6.925428
33P:P:F270 6.99167626
34P:P:E277 5.6425426
35P:P:R287 6.972508
36P:P:L288 6.135407
37P:P:F294 5.552507
38P:P:F298 8.214565
39P:P:L307 4.91754124
40P:P:S310 3.394125
41R:R:I44 4.14404
42R:R:I59 2.83405
43R:R:V74 5.83254178
44R:R:L81 6.1325406
45R:R:Q85 5.39447
46R:R:I98 4.082503
47R:R:L104 2.8675404
48R:R:F114 4.625406
49R:R:D117 7.2975418
50R:R:Y121 7.746517
51R:R:S122 6.04446
52R:R:F126 6.60286744
53R:R:L128 4.2925407
54R:R:F129 5.115407
55R:R:R134 7.2265179
56R:R:Y140 8.46435
57R:R:R142 4.96507
58R:R:E148 6.14406
59R:R:F162 8.49406
60R:R:W164 7.152546
61R:R:L166 5.3975415
62R:R:V172 3.765405
63R:R:W184 8.76754162
64R:R:C187 4.265408
65R:R:K201 11.7525418
66R:R:W203 10.8125415
67R:R:F204 7.504518
68R:R:M210 8.8725407
69R:R:L220 4.955433
70R:R:Y222 7.695407
71R:R:R225 8.242533
72R:R:Y232 5.848507
73R:R:R235 3.565408
74R:R:F239 11.088578
75R:R:Y240 10.7625408
76R:R:Y250 6.628516
77R:R:Y251 7.71414
78R:R:F253 6.154195
79R:R:F270 8.5375406
80R:R:R287 6.59408
81R:R:L288 5.765407
82R:R:F298 8.008575
83R:R:L307 3.725404
84S:S:L81 6.7425406
85S:S:Q85 6.7825407
86S:S:I98 3.802503
87S:S:L104 1.8625404
88S:S:F114 4.625406
89S:S:D116 4.29405
90S:S:D117 7.0675418
91S:S:Y121 7.286517
92S:S:S122 6.04486
93S:S:F126 6.86684
94S:S:F129 4.4025407
95S:S:R134 6.9365229
96S:S:R142 5.0725407
97S:S:N152 6.035408
98S:S:W164 6.724586
99S:S:L166 5.7025415
100S:S:V172 4.1925405
101S:S:W184 9.2775402
102S:S:C187 3.8975408
103S:S:P190 4.4275409
104S:S:K201 12.0975418
105S:S:W203 8.014515
106S:S:F204 6.86518
107S:S:M210 8.685407
108S:S:E219 3.805405
109S:S:L220 5.634113
110S:S:Y222 7.388507
111S:S:R225 9.25754113
112S:S:Y232 6.904507
113S:S:F239 10.872598
114S:S:Y240 8.335408
115S:S:Y251 8.1625404
116S:S:F253 5.6985105
117S:S:F270 7.336676206
118S:S:E277 5.93254106
119S:S:R287 6.464508
120S:S:L288 6.135407
121S:S:F294 5.336507
122S:S:F298 8.25595
123S:S:F299 6.22406
124S:S:R301 6.114232
125S:S:L307 3.7254214
126S:S:S310 3.0554215
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1P:P:G45 P:P:I98 11.77461.76NoYes063
2P:P:G45 P:P:I44 12.9261.76NoNo064
3P:P:D274 P:P:F270 12.99348.36NoYes296
4P:P:D274 P:P:R257 15.31944.76NoNo297
5P:P:F253 P:P:R257 16.30277.48YesNo257
6P:P:F253 P:P:T280 29.1253.89YesNo054
7P:P:T280 P:P:Y250 30.27036.24NoNo046
8P:P:R281 P:P:Y250 18.70618.23NoNo046
9P:P:R281 P:P:T285 17.54063.88NoNo043
10P:P:Y250 P:P:Y251 49.6827.94NoYes064
11P:P:K201 P:P:Y251 65.037514.33YesYes084
12P:P:K201 P:P:L120 45.85844.23YesNo085
13P:P:L120 P:P:R287 27.78348.5NoYes058
14P:P:I295 P:P:L81 13.00155.71NoYes066
15P:P:K201 P:P:Y121 70.497611.94YesYes187
16P:P:F204 P:P:Y121 78.516114.44YesYes187
17P:P:F204 P:P:L125 25.40917.31YesNo185
18P:P:A163 P:P:L125 36.27394.73NoNo045
19P:P:A163 P:P:F126 35.8274.16NoYes044
20P:P:F126 P:P:L81 30.18086.09YesYes046
21P:P:I295 P:P:I58 11.92864.42NoNo067
22P:P:L120 P:P:L205 17.96944.15NoNo054
23P:P:F247 P:P:L205 17.611113.4NoNo034
24P:P:C243 P:P:F247 38.67535.59NoNo053
25P:P:C243 P:P:F239 38.71255.59NoYes058
26P:P:F239 P:P:F298 63.30449.65YesYes685
27P:P:F298 P:P:Y232 79.84369.28YesYes057
28P:P:R134 P:P:Y232 69.60497.2YesYes097
29P:P:R134 P:P:V74 29.63937.85YesYes1398
30P:P:F247 P:P:R287 21.41756.41NoYes038
31P:P:F299 P:P:V74 20.16245.24NoYes068
32P:P:F299 P:P:L65 15.92629.74NoNo067
33P:P:L65 P:P:S310 12.13694.5NoYes1275
34P:P:S310 P:P:V67 13.25111.62YesNo055
35P:P:D133 P:P:R134 33.28178.34NoYes089
36P:P:F162 P:P:L166 47.1989.74YesYes065
37P:P:F204 P:P:L166 36.82444.87YesYes185
38P:P:D197 P:P:K201 27.019512.44NoYes078
39P:P:D197 P:P:I189 25.86618.4NoNo077
40P:P:I189 P:P:T177 24.71064.56NoNo075
41P:P:T177 P:P:Y193 23.553214.98NoNo058
42P:P:P190 P:P:Y193 21.23236.95NoNo098
43P:P:G178 P:P:P190 14.23842.03NoNo079
44P:P:G178 P:P:L113 13.06291.71NoNo075
45P:P:F239 P:P:Y240 43.177212.38YesYes088
46P:P:D133 S:S:Y222 32.434210.34NoYes087
47P:P:A137 P:P:R134 32.47055.53NoYes099
48P:P:A137 S:S:Y222 32.04779.34NoYes097
49P:P:R142 S:S:Y222 61.2194.12YesYes077
50P:P:R142 P:P:Y140 60.4395.14YesNo075
51P:P:R225 P:P:Y140 36.538620.58YesNo035
52P:P:Y140 S:S:S223 28.6546.36NoNo054
53P:P:R142 S:S:R226 10.20257.46YesNo078
54P:P:F162 S:S:M210 43.645214.93YesYes067
55P:P:F204 P:P:W203 98.20457.02YesYes185
56P:P:W203 S:S:W203 49.53810.31YesYes155
57S:S:F204 S:S:W203 1008.02YesYes185
58S:S:F204 S:S:Y121 83.944912.38YesYes187
59S:S:K201 S:S:Y121 44.093111.94YesYes187
60S:S:K201 S:S:Y251 42.610614.33YesYes084
61S:S:L198 S:S:Y251 11.25833.52NoYes074
62P:P:P173 S:S:L198 10.24483.28NoNo087
63P:P:W203 R:R:W203 49.039811.25YesYes155
64P:P:L198 P:P:Y251 14.23843.52NoYes074
65P:P:L198 R:R:P173 13.06293.28NoNo078
66R:R:P173 R:R:V172 11.88533.53NoYes085
67P:P:M210 P:P:Y240 42.22719.58NoYes078
68R:R:F204 R:R:W203 99.608510.02YesYes185
69R:R:F204 R:R:L166 38.19524.87YesYes185
70R:R:F162 R:R:L166 42.04399.74YesYes065
71R:R:F129 R:R:F162 19.58574.29YesYes076
72P:P:R225 P:P:S223 25.31855.27YesNo334
73P:P:S223 R:R:Y140 28.23235.09NoYes345
74R:R:R142 R:R:Y140 54.8315.14YesYes075
75P:P:R226 R:R:R142 12.53557.46NoYes087
76P:P:R226 P:P:W230 10.54676NoYes086
77R:R:F204 R:R:L125 37.76656.09YesNo185
78R:R:A163 R:R:L125 42.02484.73NoNo045
79R:R:A163 R:R:F126 41.49744.16NoYes044
80R:R:F126 R:R:L81 33.53836.09YesYes046
81R:R:F127 R:R:L81 31.23559.74NoYes076
82R:R:F127 R:R:F298 24.44594.29NoYes775
83R:R:F298 R:R:Y232 66.12058.25YesYes057
84R:R:R134 R:R:Y232 58.39197.2YesYes097
85R:R:D133 R:R:R134 28.59468.34NoYes089
86P:P:Y222 R:R:D133 27.944410.34YesNo078
87P:P:Y222 R:R:R142 53.67864.12YesYes077
88S:S:F204 S:S:L166 37.86114.87YesYes185
89S:S:F162 S:S:L166 50.659210.96NoYes065
90R:R:M210 S:S:F162 48.65448.71YesNo076
91R:R:M210 R:R:Y240 48.012219.16YesYes078
92R:R:F239 R:R:Y240 52.068313.41YesYes088
93R:R:F239 R:R:F298 43.08669.65YesYes785
94R:R:A137 R:R:R134 27.8765.53NoYes099
95P:P:Y222 R:R:A137 27.55199.34YesNo079
96P:P:R225 S:S:E219 10.38974.65YesYes035
97R:R:R225 R:R:Y140 30.870218.52YesYes335
98P:P:E219 R:R:R225 12.74284.65YesYes053
99S:S:M210 S:S:Y240 41.39889.58YesYes078
100S:S:F239 S:S:Y240 41.806413.41YesYes088
101S:S:F239 S:S:F298 51.43528.57YesYes985
102S:S:F298 S:S:Y232 67.1329.28YesYes057
103S:S:R134 S:S:Y232 62.63817.2YesYes097
104S:S:D133 S:S:R134 27.74718.34NoYes089
105R:R:Y222 S:S:D133 27.070810.34YesNo078
106R:R:Y222 S:S:R142 56.81584.12YesYes077
107S:S:R142 S:S:Y140 56.16465.14YesNo075
108R:R:S223 S:S:Y140 32.68995.09NoNo045
109R:R:R225 R:R:S223 29.66755.27YesNo334
110S:S:A137 S:S:R134 26.97725.53NoYes099
111R:R:Y222 S:S:A137 26.6399.34YesNo079
112P:P:R235 P:P:Y232 10.98255.14NoYes087
113R:R:F204 R:R:Y121 88.996412.38YesYes187
114R:R:K201 R:R:Y121 68.584311.94YesYes187
115R:R:D197 R:R:K201 22.066712.44NoYes078
116R:R:D197 R:R:I189 21.12867NoNo077
117R:R:I189 R:R:P190 20.18863.39NoNo079
118R:R:P190 R:R:S179 16.40835.34NoNo094
119R:R:L106 R:R:S179 15.45823NoNo024
120R:R:L106 R:R:R110 14.50616.07NoNo028
121R:R:K201 R:R:Y251 51.017514.33YesYes184
122R:R:Y250 R:R:Y251 39.48055.96YesYes164
123R:R:R254 R:R:Y250 36.81744.12NoYes086
124R:R:Q188 R:R:R254 34.093911.68NoNo058
125R:R:D181 R:R:Q188 27.668618.27NoNo055
126R:R:D181 R:R:W184 26.74274.47NoYes052
127R:R:F270 R:R:W184 23.952813.03YesYes062
128R:R:F270 R:R:R37 17.37254.28YesNo066
129R:R:L185 R:R:R37 15.47438.5NoNo016
130R:R:L185 R:R:R101 14.52228.5NoNo012
131R:R:D41 R:R:R101 12.6123.57NoNo042
132R:R:D41 R:R:I98 11.65387NoYes043
133R:R:D117 R:R:Y121 13.62656.9YesYes187
134R:R:D116 R:R:D117 14.82225.32NoYes058
135R:R:D116 R:R:T92 12.97134.34NoNo056
136R:R:L288 R:R:T92 12.4634.42YesNo076
137R:R:L288 R:R:S51 10.19853YesNo078
138R:R:I295 R:R:L81 13.05384.28NoYes066
139R:R:I295 R:R:I58 12.00314.42NoNo067
140R:R:R134 R:R:V74 28.01087.85YesYes1798
141R:R:T78 R:R:V74 11.97393.17NoYes058
142R:R:L62 R:R:T78 10.65142.95NoNo065
143R:R:F299 R:R:V74 15.49755.24NoYes068
144R:R:G178 R:R:R110 11.65381.5NoNo078
145R:R:G178 R:R:L113 10.69371.71NoNo075
146R:R:C243 R:R:F239 12.57885.59NoYes058
147R:R:C243 R:R:F247 11.86525.59NoNo053
148R:R:F129 R:R:L128 14.08744.87YesYes077
149R:R:L128 R:R:P209 14.486.57YesNo079
150R:R:P209 R:R:Y240 14.99934.17NoYes098
151S:S:F204 S:S:L125 30.40324.87YesNo185
152S:S:A163 S:S:L125 43.6074.73NoNo045
153S:S:A163 S:S:F126 43.09874.16NoYes044
154S:S:F126 S:S:V160 16.85326.55YesNo846
155S:S:I76 S:S:V160 16.77973.07NoNo066
156S:S:I76 S:S:V72 15.94033.07NoNo063
157S:S:E148 S:S:V72 15.44525.7NoNo063
158R:R:R235 R:R:Y232 15.49153.09YesYes087
159R:R:P303 R:R:R235 11.64175.76NoYes088
160R:R:L198 R:R:Y251 10.69373.52NoYes074
161S:S:D197 S:S:K201 12.239612.44NoYes078
162S:S:D197 S:S:I189 11.22818.4NoNo077
163S:S:I189 S:S:P190 10.22973.39NoYes079
164S:S:Y250 S:S:Y251 30.13258.94NoYes064
165S:S:T280 S:S:Y250 28.17994.99NoNo046
166S:S:F253 S:S:T280 27.20063.89YesNo054
167S:S:E277 S:S:F253 20.22585.83YesYes1065
168S:S:E277 S:S:Q188 18.24215.1YesNo1065
169S:S:D181 S:S:Q188 17.29710.44NoNo055
170S:S:D181 S:S:W184 16.29564.47NoYes052
171S:S:F270 S:S:W184 11.258314.03YesYes062
172S:S:D117 S:S:Y121 33.74564.6YesYes187
173S:S:D116 S:S:D117 43.27785.32YesYes058
174S:S:D116 S:S:T92 30.26234.34YesNo056
175S:S:M93 S:S:T92 30.69413.01NoNo046
176S:S:I98 S:S:M93 23.73145.83YesNo034
177S:S:I98 S:S:K96 19.04934.36YesNo035
178S:S:F127 S:S:L81 23.655910.96NoYes076
179S:S:F126 S:S:L81 23.69517.31YesYes046
180S:S:R134 S:S:V74 38.72567.85YesNo2298
181S:S:F299 S:S:V74 44.84995.24YesNo068
182S:S:F299 S:S:T78 14.60073.89YesNo065
183S:S:L62 S:S:T78 12.98642.95NoNo065
184S:S:L62 S:S:W79 11.372.28NoNo064
185S:S:F299 S:S:L65 25.80378.53YesNo067
186S:S:L65 S:S:S310 14.54644.5NoYes2175
187S:S:I138 S:S:Y232 15.14424.84NoYes057
188S:S:D116 S:S:R287 24.66335.96YesYes058
189S:S:L288 S:S:T92 11.72935.9YesNo076
190S:S:L288 S:S:R287 14.50718.5YesYes078
191S:S:G186 S:S:K96 15.51665.23NoNo045
192S:S:C187 S:S:G186 14.3351.96YesNo084
193S:S:C243 S:S:F239 28.1875.59NoYes058
194S:S:C243 S:S:F247 27.80055.59NoNo053
195S:S:R225 S:S:S223 24.91396.59YesNo1134
196S:S:L288 S:S:S51 10.02943YesNo078
197P:P:I44 P:P:T285 16.37714.56NoNo043
198P:P:F127 P:P:F298 18.17474.29NoYes675
199P:P:F127 P:P:L81 25.144410.96NoYes076
200P:P:L125 P:P:L166 11.45154.15NoYes155
201P:P:M210 R:R:F162 42.455617.42NoYes076
202R:R:F299 R:R:L65 11.596410.96NoNo067
203S:S:R225 S:S:Y140 26.834316.46YesNo035
204S:S:F247 S:S:R287 27.19966.41NoYes038
205R:R:W203 S:S:W203 50.853510.31YesYes155
206S:S:F127 S:S:F298 17.04854.29NoYes975
207S:S:L125 S:S:L166 13.79764.15NoYes155
208S:S:D117 S:S:K201 10.64439.68YesYes188
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8Z1E
Class A
SubFamily Orphan
Type Orphan
SubType UL78
Species Human herpesvirus 5
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.12
Date 2024-05-15 
D.O.I. 10.1038/s41421-024-00684-x
Net Summary
Imin 3.89
Number of Linked Nodes 773
Number of Links 856
Number of Hubs 126
Number of Links mediated by Hubs 465
Number of Communities 23
Number of Nodes involved in Communities 122
Number of Links involved in Communities 148
Path Summary
Number Of Nodes in MetaPath 209
Number Of Links MetaPath 208
Number of Shortest Paths 471054
Length Of Smallest Path 3
Average Path Length 17.6141
Length of Longest Path 39
Minimum Path Strength 1.225
Average Path Strength 7.37434
Maximum Path Strength 20.91
Minimum Path Correlation 0.7
Average Path Correlation 0.954146
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.84615
Average % Of Corr. Nodes 50.9263
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 54.6135
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainP
ProteinReceptor
UniProtP16751
Sequence
>8Z1E_Chain_P
SADRAASDL LIGMFGSVS LVNLLTIIG CLWVLRVTR PPVSVMIFT 
WNLVLSQFF SILATMLSK GIMLRGALN LSLCRLVLF VDDVGLYST 
ALFFLFLIL DRLSAISYG RDLWHHETR ENAGVALYA VAFAWVLSI 
VAAVPTAAT GSLDYRWLG CQIPIQYAA VDLTIKMWF LLGAPMIAV 
LANVVELAY SDRRDHVWS YVGRVCTFY VTCLMLFVP YYCFRVLRG 
VLQGFGIMD YVELATRTL LTMRLGILP LFIIAFFSR EPTKDLDDS 
FDYLVERC


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP16751
Sequence
>8Z1E_Chain_R
SADRAASDL LIGMFGSVS LVNLLTIIG CLWVLRVTR PPVSVMIFT 
WNLVLSQFF SILATMLSK GIMLRGALN LSLCRLVLF VDDVGLYST 
ALFFLFLIL DRLSAISYG RDLWHHETR ENAGVALYA VAFAWVLSI 
VAAVPTAAT GSLDYRWLG CQIPIQYAA VDLTIKMWF LLGAPMIAV 
LANVVELAY SDRRDHVWS YVGRVCTFY VTCLMLFVP YYCFRVLRG 
VLQGFGIMD YVELATRTL LTMRLGILP LFIIAFFSR EPTKDLDDS 
FDYLVERC


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtP16751
Sequence
>8Z1E_Chain_S
SADRAASDL LIGMFGSVS LVNLLTIIG CLWVLRVTR PPVSVMIFT 
WNLVLSQFF SILATMLSK GIMLRGALN LSLCRLVLF VDDVGLYST 
ALFFLFLIL DRLSAISYG RDLWHHETR ENAGVALYA VAFAWVLSI 
VAAVPTAAT GSLDYRWLG CQIPIQYAA VDLTIKMWF LLGAPMIAV 
LANVVELAY SDRRDHVWS YVGRVCTFY VTCLMLFVP YYCFRVLRG 
VLQGFGIMD YVELATRTL LTMRLGILP LFIIAFFSR EPTKDLDDS 
FDYLVERC


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8Z1EAOrphanOrphanUL78Human herpesvirus 5---3.122024-05-1510.1038/s41421-024-00684-x
8Z1E (Multimeric) AOrphanOrphanUL78Human herpesvirus 5--3.122024-05-1510.1038/s41421-024-00684-x




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