psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D10	inf	Yes	Yes	1	0	7
2	L:L:?1	R:R:T13	inf	Yes	No	1	0	7
3	L:L:?1	R:R:Y104	inf	Yes	Yes	1	0	5
4	L:L:?1	R:R:Y108	inf	Yes	No	1	0	7
5	L:L:?1	R:R:Y165	inf	Yes	Yes	1	0	1
6	L:L:?1	R:R:F176	inf	Yes	No	1	0	4
7	L:L:?1	R:R:V178	inf	Yes	No	1	0	3
8	L:L:?1	R:R:L179	inf	Yes	No	0	0	4
9	L:L:?1	R:R:W181	inf	Yes	No	0	0	2
10	L:L:?1	R:R:W190	inf	Yes	No	0	0	3
11	L:L:?1	R:R:L194	inf	Yes	No	1	0	5
12	L:L:?1	R:R:I197	inf	Yes	No	0	0	5
13	L:L:?1	R:R:L257	inf	Yes	No	1	0	6
14	L:L:?1	R:R:H260	inf	Yes	Yes	1	0	4
15	L:L:?1	R:R:I261	inf	Yes	Yes	1	0	5
16	L:L:?1	R:R:R264	inf	Yes	No	1	0	3
17	L:L:?1	R:R:L265	inf	Yes	No	0	0	1
18	L:L:?1	R:R:Y272	inf	Yes	Yes	1	0	4
19	L:L:?1	R:R:Y275	inf	Yes	Yes	1	0	5
20	R:R:D10	R:R:T13	8.67	Yes	No	1	7	7
21	R:R:D10	R:R:R264	10.72	Yes	No	1	7	3
22	R:R:L17	R:R:M16	4.24	No	No	0	6	6
23	R:R:M16	R:R:Y272	5.99	No	Yes	0	6	4
24	R:R:H87	R:R:L17	14.14	Yes	No	0	4	6
25	R:R:L17	R:R:T174	4.42	No	No	0	6	4
26	R:R:L170	R:R:R18	4.86	No	No	0	3	4
27	R:R:N19	R:R:P20	4.89	No	No	0	5	2
28	R:R:I22	R:R:N19	14.16	No	No	0	4	5
29	R:R:I22	R:R:K276	4.36	No	No	0	4	4
30	R:R:L26	R:R:Y30	10.55	No	Yes	0	6	8
31	R:R:H83	R:R:L26	7.71	Yes	No	0	5	6
32	R:R:C280	R:R:V29	10.25	No	No	0	6	5
33	R:R:I80	R:R:Y30	4.84	No	Yes	0	7	8
34	R:R:I80	R:R:S31	6.19	No	No	0	7	4
35	R:R:C287	R:R:V33	5.12	No	No	0	8	7
36	R:R:C287	R:R:V36	5.12	No	No	0	8	5
37	R:R:D69	R:R:N41	5.39	Yes	No	0	9	9
38	R:R:N41	R:R:P290	4.89	No	No	0	9	9
39	R:R:F43	R:R:V47	7.87	No	No	0	6	7
40	R:R:F43	R:R:L304	7.31	No	No	0	6	6
41	R:R:S44	R:R:Y294	7.63	No	Yes	0	8	7
42	R:R:L45	R:R:S66	9.01	No	No	0	7	9
43	R:R:L45	R:R:V67	4.47	No	No	0	7	6
44	R:R:R50	R:R:W46	18.99	No	No	0	4	3
45	R:R:R51	R:R:W46	7	No	No	0	5	3
46	R:R:R51	R:R:V47	5.23	No	No	0	5	7
47	R:R:F300	R:R:V47	6.55	Yes	No	0	8	7
48	R:R:L48	R:R:M52	4.24	No	No	0	7	5
49	R:R:L48	R:R:Y294	16.41	No	Yes	5	7	7
50	R:R:F300	R:R:L48	9.74	Yes	No	5	8	7
51	R:R:S56	R:R:S58	4.89	No	No	0	7	7
52	R:R:E120	R:R:P57	6.29	No	No	0	8	6
53	R:R:E120	R:R:S58	5.75	No	No	0	8	7
54	R:R:C116	R:R:F61	9.78	No	Yes	0	7	7
55	R:R:F61	R:R:I117	5.02	Yes	No	0	7	9
56	R:R:E120	R:R:F61	4.66	No	Yes	0	8	7
57	R:R:M62	R:R:Y294	9.58	No	Yes	0	8	7
58	R:R:N64	R:R:T68	4.39	No	Yes	0	9	8
59	R:R:N64	R:R:T113	10.24	No	No	0	9	8
60	R:R:C144	R:R:N64	4.72	No	No	0	8	9
61	R:R:L65	R:R:T113	5.9	No	No	0	9	8
62	R:R:L65	R:R:M114	4.24	No	Yes	3	9	9
63	R:R:D289	R:R:L65	9.5	Yes	No	3	9	9
64	R:R:S66	R:R:Y294	5.09	No	Yes	0	9	7
65	R:R:N106	R:R:T68	7.31	No	Yes	0	8	8
66	R:R:S109	R:R:T68	9.59	No	Yes	0	7	8
67	R:R:S110	R:R:T68	4.8	No	Yes	0	9	8
68	R:R:D69	R:R:S110	5.89	Yes	No	0	9	9
69	R:R:D69	R:R:N286	13.46	Yes	No	0	9	9
70	R:R:D289	R:R:D69	9.31	Yes	Yes	0	9	9
71	R:R:M71	R:R:N106	9.82	No	No	0	6	8
72	R:R:L72	R:R:M107	7.07	No	No	0	7	8
73	R:R:L72	R:R:N286	9.61	No	No	0	7	9
74	R:R:F78	R:R:F91	9.65	No	Yes	0	6	7
75	R:R:F78	R:R:L95	6.09	No	No	0	6	5
76	R:R:F78	R:R:V99	10.49	No	No	0	6	4
77	R:R:Q79	R:R:V99	4.3	No	No	0	6	4
78	R:R:N85	R:R:Y81	4.65	No	No	0	4	4
79	R:R:V90	R:R:Y81	11.36	No	No	2	1	4
80	R:R:F91	R:R:Y81	7.22	Yes	No	2	7	4
81	R:R:H83	R:R:Y82	6.53	Yes	Yes	2	5	5
82	R:R:H87	R:R:Y82	7.62	Yes	Yes	2	4	5
83	R:R:W89	R:R:Y82	5.79	Yes	Yes	2	9	5
84	R:R:D177	R:R:Y82	16.09	No	Yes	2	4	5
85	R:R:H83	R:R:H87	4.78	Yes	Yes	2	5	4
86	R:R:H88	R:R:N85	10.2	No	No	0	4	4
87	R:R:D177	R:R:H87	6.3	No	Yes	2	4	4
88	R:R:H88	R:R:I172	7.95	No	No	0	4	3
89	R:R:F91	R:R:W89	18.04	Yes	Yes	2	7	9
90	R:R:C96	R:R:W89	5.22	No	Yes	2	9	9
91	R:R:C175	R:R:W89	18.28	No	Yes	2	9	9
92	R:R:F91	R:R:V90	7.87	Yes	No	2	7	1
93	R:R:D162	R:R:V93	8.76	No	No	0	4	3
94	R:R:C175	R:R:C96	5.46	No	No	2	9	9
95	R:R:L163	R:R:N97	5.49	Yes	No	0	4	7
96	R:R:L163	R:R:T100	5.9	Yes	No	0	4	5
97	R:R:F103	R:R:Y104	10.32	Yes	Yes	0	6	5
98	R:R:F103	R:R:M107	6.22	Yes	No	0	6	8
99	R:R:F103	R:R:L279	7.31	Yes	No	0	6	5
100	R:R:Y104	R:R:Y108	6.95	Yes	No	1	5	7
101	R:R:F176	R:R:Y104	6.19	No	Yes	1	4	5
102	R:R:Y104	R:R:Y275	4.96	Yes	Yes	1	5	5
103	R:R:N106	R:R:W148	4.52	No	No	0	8	9
104	R:R:M107	R:R:S282	4.6	No	No	0	8	8
105	R:R:L201	R:R:Y108	7.03	Yes	No	0	5	7
106	R:R:S109	R:R:W148	11.12	No	No	0	7	9
107	R:R:F250	R:R:I111	15.07	No	No	0	9	8
108	R:R:L112	R:R:T147	7.37	Yes	No	0	6	7
109	R:R:L112	R:R:P205	4.93	Yes	No	0	6	9
110	R:R:F246	R:R:M114	7.46	Yes	Yes	0	9	9
111	R:R:M114	R:R:N285	7.01	Yes	Yes	3	9	9
112	R:R:D289	R:R:M114	5.54	Yes	Yes	3	9	9
113	R:R:M114	R:R:Y293	7.18	Yes	No	0	9	9
114	R:R:P205	R:R:T115	6.99	No	No	0	9	8
115	R:R:T115	R:R:T209	6.28	No	No	0	8	8
116	R:R:I117	R:R:R121	6.26	No	No	0	9	9
117	R:R:S118	R:R:T209	9.59	No	No	0	9	8
118	R:R:S118	R:R:Y213	7.63	No	Yes	0	9	9
119	R:R:R121	R:R:Y213	6.17	No	Yes	0	9	9
120	R:R:F122	R:R:L126	12.18	Yes	No	6	8	7
121	R:R:F122	R:R:Y127	9.28	Yes	Yes	6	8	6
122	R:R:C212	R:R:F122	5.59	No	Yes	0	7	8
123	R:R:L123	R:R:S131	7.51	No	Yes	0	6	6
124	R:R:G124	R:R:R135	4.5	No	No	0	8	6
125	R:R:T216	R:R:V125	4.76	No	No	0	8	8
126	R:R:L126	R:R:Y127	10.55	No	Yes	6	7	6
127	R:R:K219	R:R:L126	7.05	No	No	0	5	7
128	R:R:R136	R:R:R138	10.66	No	No	7	6	4
129	R:R:R136	R:R:Y139	12.35	No	No	7	6	3
130	R:R:R138	R:R:Y139	10.29	No	No	7	4	3
131	R:R:P157	R:R:S156	5.34	No	No	8	8	3
132	R:R:R160	R:R:S156	6.59	No	No	8	3	3
133	R:R:P157	R:R:R160	4.32	No	No	8	8	3
134	R:R:F193	R:R:P157	7.22	No	No	0	6	8
135	R:R:M183	R:R:T161	13.55	No	No	0	2	4
136	R:R:D162	R:R:T164	8.67	No	No	0	4	5
137	R:R:V178	R:R:Y165	7.57	No	Yes	1	3	1
138	R:R:K180	R:R:Y165	4.78	No	Yes	0	3	1
139	R:R:H168	R:R:P166	7.63	No	No	0	3	3
140	R:R:I172	R:R:L170	5.71	No	No	0	3	3
141	R:R:L184	R:R:P185	4.93	No	No	0	1	1
142	R:R:L184	R:R:W190	12.53	No	No	0	1	3
143	R:R:M189	R:R:P185	6.71	No	No	0	6	1
144	R:R:F193	R:R:I197	11.3	No	No	0	6	5
145	R:R:I261	R:R:L194	7.14	Yes	No	1	5	5
146	R:R:F195	R:R:I261	5.02	No	Yes	0	5	5
147	R:R:I197	R:R:L201	4.28	No	Yes	0	5	5
148	R:R:F198	R:R:F202	7.5	No	Yes	0	7	8
149	R:R:F198	R:R:L258	13.4	No	No	0	7	5
150	R:R:F202	R:R:F206	11.79	Yes	Yes	4	8	7
151	R:R:F202	R:R:N254	22.96	Yes	No	0	8	8
152	R:R:F202	R:R:F255	8.57	Yes	No	4	8	6
153	R:R:F206	R:R:F246	6.43	Yes	Yes	0	7	9
154	R:R:F206	R:R:F255	4.29	Yes	No	4	7	6
155	R:R:F246	R:R:T209	16.86	Yes	No	0	9	8
156	R:R:V242	R:R:Y213	8.83	No	Yes	0	8	9
157	R:R:L218	R:R:R222	7.29	No	No	0	3	3
158	R:R:L221	R:R:V236	5.96	No	No	0	4	5
159	R:R:R232	R:R:T223	9.06	Yes	No	0	7	5
160	R:R:E225	R:R:H227	4.92	No	No	0	3	3
161	R:R:G228	R:R:Q231	6.58	No	No	0	3	5
162	R:R:R229	R:R:R232	6.4	No	Yes	0	3	7
163	R:R:R234	R:R:R298	7.46	No	Yes	9	7	5
164	R:R:E299	R:R:R234	5.82	No	No	9	6	7
165	R:R:V242	R:R:V292	4.81	No	No	0	8	7
166	R:R:V242	R:R:Y293	8.83	No	No	0	8	9
167	R:R:F246	R:R:F250	5.36	Yes	No	0	9	9
168	R:R:C249	R:R:N285	9.45	No	Yes	0	9	9
169	R:R:F250	R:R:N285	12.08	No	Yes	0	9	9
170	R:R:N253	R:R:Y275	11.63	Yes	Yes	1	7	5
171	R:R:N253	R:R:T278	8.77	Yes	No	0	7	8
172	R:R:L279	R:R:N253	6.87	No	Yes	1	5	7
173	R:R:N253	R:R:S282	8.94	Yes	No	0	7	8
174	R:R:V256	R:R:V274	4.81	No	No	0	5	5
175	R:R:T278	R:R:V256	4.76	No	No	0	8	5
176	R:R:I261	R:R:L257	7.14	Yes	No	1	5	6
177	R:R:L257	R:R:Y275	9.38	No	Yes	1	6	5
178	R:R:H260	R:R:R264	4.51	Yes	No	1	4	3
179	R:R:H260	R:R:S270	6.97	Yes	No	0	4	4
180	R:R:H260	R:R:Y272	10.89	Yes	Yes	1	4	4
181	R:R:V262	R:R:Y267	5.05	No	No	0	4	1
182	R:R:S263	R:R:Y271	11.45	No	No	0	4	3
183	R:R:F266	R:R:L265	9.74	No	No	0	2	1
184	R:R:F266	R:R:Y267	6.19	No	No	0	2	1
185	R:R:K276	R:R:Y272	13.14	No	Yes	0	4	4
186	R:R:H273	R:R:V274	6.92	No	No	0	1	5
187	R:R:L279	R:R:Y275	7.03	No	Yes	1	5	5
188	R:R:D289	R:R:N285	9.42	Yes	Yes	3	9	9
189	R:R:F295	R:R:P290	7.22	No	No	0	6	9
190	R:R:F291	R:R:F295	13.93	No	No	0	6	6
191	R:R:F300	R:R:Y294	5.16	Yes	Yes	5	8	7
192	R:R:F295	R:R:F300	5.36	No	Yes	0	6	8
193	R:R:E299	R:R:S297	5.75	No	No	0	6	8
194	R:R:E299	R:R:R298	13.96	No	Yes	9	6	5
195	R:R:L302	R:R:R298	6.07	No	Yes	0	4	5
196	R:R:P9	R:R:Y165	4.17	Yes	Yes	0	5	1
197	R:R:P166	R:R:Y165	4.17	No	Yes	0	3	1
198	R:R:A140	R:R:F61	4.16	No	Yes	0	7	7
199	R:R:L112	R:R:L151	4.15	Yes	No	0	6	7
200	R:R:G8	R:R:P9	4.06	No	Yes	0	6	5
201	R:R:G53	R:R:P54	4.06	No	No	0	5	6
202	R:R:C280	R:R:Y30	4.03	No	Yes	0	6	8
203	R:R:C283	R:R:Y30	4.03	No	Yes	0	7	8
204	R:R:H88	R:R:I173	3.98	No	No	0	4	3
205	R:R:R135	R:R:S131	3.95	No	Yes	0	6	6
206	R:R:F206	R:R:V210	3.93	Yes	No	0	7	4
207	R:R:F176	R:R:T100	3.89	No	No	0	4	5
208	R:R:E230	R:R:Q231	3.82	No	No	0	3	5
209	R:R:C84	R:R:P27	3.77	No	No	0	4	5
210	R:R:F198	R:R:L203	3.65	No	No	0	7	4
211	R:R:P9	R:R:V167	3.53	Yes	No	0	5	1
212	R:R:A73	R:R:S37	3.42	No	No	0	6	8
213	R:R:I38	R:R:P39	3.39	No	No	0	6	4
214	R:R:I60	R:R:P54	3.39	No	No	0	6	6
215	R:R:A102	R:R:V75	3.39	No	No	0	5	7
216	R:R:I204	R:R:P205	3.39	No	No	0	5	9
217	R:R:A245	R:R:V292	3.39	No	No	0	6	7
218	R:R:C96	R:R:T164	3.38	No	No	0	9	5
219	R:R:L14	R:R:P9	3.28	No	Yes	0	5	5
220	R:R:L281	R:R:P252	3.28	No	No	0	8	9
221	R:R:C49	R:R:I63	3.27	No	No	0	4	6
222	R:R:A239	R:R:I217	3.25	No	No	0	7	5
223	R:R:S56	R:R:V59	3.23	No	No	0	7	7
224	R:R:A169	R:R:L14	3.15	No	No	0	5	5
225	R:R:A34	R:R:L76	3.15	No	Yes	0	7	8
226	R:R:A154	R:R:L201	3.15	No	Yes	0	5	5
227	R:R:A235	R:R:L220	3.15	No	Yes	0	7	7
228	R:R:I63	R:R:V59	3.07	No	No	0	6	7
229	R:R:M189	R:R:S186	3.07	No	No	0	6	3
230	R:R:H83	R:R:P27	3.05	Yes	No	0	5	5
231	R:R:I208	R:R:T115	3.04	No	No	0	6	8
232	R:R:R133	R:R:W134	3	No	No	0	4	4
233	R:R:L76	R:R:V33	2.98	Yes	No	0	8	7
234	R:R:N286	R:R:S37	2.98	No	No	0	9	8
235	R:R:L95	R:R:V98	2.98	No	No	0	5	4
236	R:R:L123	R:R:V119	2.98	No	No	0	6	6
237	R:R:L220	R:R:V125	2.98	Yes	No	0	7	8
238	R:R:L220	R:R:V236	2.98	Yes	No	0	7	5
239	R:R:L163	R:R:T161	2.95	Yes	No	0	4	4
240	R:R:I199	R:R:I204	2.94	No	No	0	5	5
241	R:R:I22	R:R:L277	2.85	No	No	0	4	6
242	R:R:I199	R:R:L200	2.85	No	No	0	5	4
243	R:R:I217	R:R:L221	2.85	No	No	0	5	4
244	R:R:A143	R:R:F61	2.77	No	Yes	0	6	7
245	R:R:L112	R:R:L150	2.77	Yes	No	0	6	4
246	R:R:A215	R:R:F122	2.77	No	Yes	0	3	8
247	R:R:L155	R:R:L201	2.77	No	Yes	0	7	5
248	R:R:L158	R:R:L163	2.77	No	Yes	0	4	4
249	R:R:A191	R:R:F195	2.77	No	No	0	2	5
250	R:R:A251	R:R:F206	2.77	No	Yes	4	6	7
251	R:R:A251	R:R:F255	2.77	No	No	4	6	6
252	R:R:L70	R:R:N41	2.75	No	No	0	7	9
253	R:R:A239	R:R:Y213	2.67	No	Yes	0	7	9
254	R:R:A259	R:R:Y271	2.67	No	No	0	4	3
255	R:R:F103	R:R:V75	2.62	Yes	No	0	6	7
256	R:R:F206	R:R:V247	2.62	Yes	No	0	7	5
257	R:R:F122	R:R:T216	2.59	Yes	No	0	8	8
258	R:R:S131	R:R:Y127	2.54	Yes	Yes	0	6	6
259	R:R:S263	R:R:Y267	2.54	No	No	0	4	1
260	R:R:K132	R:R:R135	2.48	No	No	0	5	6
261	R:R:V187	R:R:W181	2.45	No	No	0	3	2
262	R:R:F103	R:R:L76	2.44	Yes	Yes	0	6	8
263	R:R:L238	R:R:R234	2.43	No	No	0	8	7
264	R:R:L243	R:R:Y213	2.34	No	Yes	0	7	9
265	R:R:E225	R:R:R232	2.33	No	Yes	0	3	7
266	R:R:G40	R:R:P39	2.03	No	No	0	8	4
267	R:R:A251	R:R:P252	1.87	No	No	0	6	9
268	R:R:G171	R:R:I172	1.76	No	No	0	4	3
269	R:R:G53	R:R:M52	1.75	No	No	0	5	5
270	R:R:G146	R:R:L149	1.71	No	No	0	4	4
271	R:R:A188	R:R:S186	1.71	No	No	0	5	3
272	R:R:A105	R:R:V101	1.7	No	No	0	6	5
273	R:R:L76	R:R:P77	1.64	Yes	No	0	8	9
274	R:R:A34	R:R:I38	1.62	No	No	0	7	6
275	R:R:A73	R:R:I38	1.62	No	No	0	6	6
276	R:R:A240	R:R:I217	1.62	No	No	0	5	5
277	R:R:V241	R:R:V292	1.6	No	No	0	6	7
278	R:R:T100	R:R:V101	1.59	No	No	0	5	5
279	R:R:T214	R:R:V210	1.59	No	No	0	3	4
280	R:R:G228	R:R:H227	1.59	No	No	0	3	3
281	R:R:C249	R:R:L284	1.59	No	No	0	9	5
282	R:R:C249	R:R:L288	1.59	No	No	0	9	6
283	R:R:A25	R:R:L277	1.58	No	No	0	5	6
284	R:R:A105	R:R:L152	1.58	No	No	0	6	4
285	R:R:A296	R:R:L238	1.58	No	No	0	7	8
286	R:R:A21	R:R:N19	1.56	No	No	0	2	5
287	R:R:A12	R:R:D10	1.54	No	Yes	0	4	7
288	R:R:I60	R:R:V141	1.54	No	No	0	6	3
289	R:R:K269	R:R:S263	1.53	No	No	0	1	4
290	R:R:M189	R:R:V192	1.52	No	No	0	6	3
291	R:R:F91	R:R:G92	1.51	Yes	No	0	7	8
292	R:R:K180	R:R:T182	1.5	No	No	0	3	4
293	R:R:L32	R:R:V28	1.49	No	No	0	5	6
294	R:R:L94	R:R:V98	1.49	No	No	0	2	4
295	R:R:L203	R:R:V207	1.49	No	No	0	4	3
296	R:R:L200	R:R:T196	1.47	No	No	0	4	3
297	R:R:L218	R:R:T214	1.47	No	No	0	3	3
298	R:R:L244	R:R:T248	1.47	No	No	0	5	5
299	R:R:P57	R:R:R137	1.44	No	No	0	6	2
300	R:R:P128	R:R:Y127	1.39	No	Yes	0	8	6
301	R:R:L14	R:R:N11	1.37	No	No	0	5	8
302	R:R:S130	R:R:Y127	1.27	No	Yes	0	4	6
303	R:R:M52	R:R:R303	1.24	No	No	0	5	4
304	R:R:S131	R:R:W134	1.24	Yes	No	0	6	4
305	R:R:L220	R:R:R232	1.21	Yes	Yes	0	7	7
306	R:R:Q301	R:R:R298	1.17	No	Yes	0	8	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	inf	19	1	0
2	R:R:P9	3.76	4	0	5
3	R:R:D10	inf	4	1	7
4	R:R:Y30	5.8625	4	0	8
5	R:R:F61	5.278	5	0	7
6	R:R:T68	6.5225	4	0	8
7	R:R:D69	8.5125	4	0	9
8	R:R:L76	2.5525	4	0	8
9	R:R:Y82	9.0075	4	2	5
10	R:R:H83	5.5175	4	2	5
11	R:R:H87	8.21	4	2	4
12	R:R:W89	11.8325	4	2	9
13	R:R:F91	8.858	5	2	7
14	R:R:F103	5.782	5	0	6
15	R:R:Y104	inf	5	1	5
16	R:R:L112	4.805	4	0	6
17	R:R:M114	6.286	5	3	9
18	R:R:F122	6.482	5	6	8
19	R:R:Y127	5.006	5	6	6
20	R:R:S131	3.81	4	0	6
21	R:R:L163	4.2775	4	0	4
22	R:R:Y165	inf	5	1	1
23	R:R:L201	4.3075	4	0	5
24	R:R:F202	12.705	4	4	8
25	R:R:F206	5.305	6	4	7
26	R:R:Y213	5.528	5	0	9
27	R:R:L220	2.58	4	0	7
28	R:R:R232	4.75	4	0	7
29	R:R:F246	9.0275	4	0	9
30	R:R:N253	9.0525	4	1	7
31	R:R:H260	inf	4	1	4
32	R:R:I261	inf	4	1	5
33	R:R:Y272	inf	4	1	4
34	R:R:Y275	inf	5	1	5
35	R:R:N285	9.49	4	3	9
36	R:R:D289	8.4425	4	3	9
37	R:R:Y294	8.774	5	5	7
38	R:R:R298	7.165	4	9	5
39	R:R:F300	6.7025	4	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y272	56.811	inf	Yes	Yes	1	0	4
2	R:R:M16	R:R:Y272	49.7357	5.99	No	Yes	0	6	4
3	R:R:L17	R:R:M16	48.8245	4.24	No	No	0	6	6
4	R:R:H87	R:R:L17	46.6535	14.14	Yes	No	0	4	6
5	R:R:H87	R:R:Y82	31.3105	7.62	Yes	Yes	2	4	5
6	R:R:W89	R:R:Y82	31.5579	5.79	Yes	Yes	2	9	5
7	R:R:F91	R:R:W89	23.8976	18.04	Yes	Yes	2	7	9
8	R:R:F91	R:R:Y81	11.5973	7.22	Yes	No	2	7	4
9	R:R:N85	R:R:Y81	10.2306	4.65	No	No	0	4	4
10	R:R:K276	R:R:Y272	10.0731	13.14	No	Yes	0	4	4
11	R:R:H83	R:R:H87	13.099	4.78	Yes	Yes	2	5	4
12	R:R:H83	R:R:L26	10.27	7.71	Yes	No	0	5	6
13	L:L:?1	R:R:Y104	76.8785	inf	Yes	Yes	1	0	5
14	R:R:F103	R:R:Y104	90.4612	10.32	Yes	Yes	0	6	5
15	R:R:F103	R:R:L76	10.6468	2.44	Yes	Yes	0	6	8
16	R:R:F103	R:R:M107	90.5624	6.22	Yes	No	0	6	8
17	R:R:L72	R:R:M107	96.4229	7.07	No	No	0	7	8
18	R:R:L72	R:R:N286	96.4398	9.61	No	No	0	7	9
19	R:R:D69	R:R:N286	100	13.46	Yes	No	0	9	9
20	R:R:D69	R:R:N41	33.892	5.39	Yes	No	0	9	9
21	R:R:N41	R:R:P290	31.4173	4.89	No	No	0	9	9
22	R:R:F295	R:R:P290	30.1631	7.22	No	No	0	6	9
23	R:R:F295	R:R:F300	27.6209	5.36	No	Yes	0	6	8
24	R:R:D289	R:R:D69	90.1237	9.31	Yes	Yes	0	9	9
25	R:R:D289	R:R:M114	81.9685	5.54	Yes	Yes	3	9	9
26	R:R:M114	R:R:Y293	57.0585	7.18	Yes	No	0	9	9
27	R:R:V242	R:R:Y293	56.0967	8.83	No	No	0	8	9
28	R:R:V242	R:R:Y213	52.8628	8.83	No	Yes	0	8	9
29	R:R:R121	R:R:Y213	20.2812	6.17	No	Yes	0	9	9
30	R:R:I117	R:R:R121	19.0382	6.26	No	No	0	9	9
31	R:R:F61	R:R:I117	17.6772	5.02	Yes	No	0	7	9
32	R:R:E120	R:R:F61	11.9516	4.66	No	Yes	0	8	7
33	R:R:D69	R:R:S110	11.9741	5.89	Yes	No	0	9	9
34	R:R:S110	R:R:T68	10.5737	4.8	No	Yes	0	9	8
35	R:R:F176	R:R:T100	13.6164	3.89	No	No	0	4	5
36	R:R:F246	R:R:M114	32.2722	7.46	Yes	Yes	0	9	9
37	R:R:F246	R:R:T209	20.6805	16.86	Yes	No	0	9	8
38	R:R:T115	R:R:T209	16.5129	6.28	No	No	0	8	8
39	R:R:P205	R:R:T115	13.6108	6.99	No	No	0	9	8
40	R:R:S118	R:R:T209	10.0169	9.59	No	No	0	9	8
41	R:R:A239	R:R:Y213	44.2745	2.67	No	Yes	0	7	9
42	R:R:A239	R:R:I217	43.1215	3.25	No	No	0	7	5
43	R:R:I217	R:R:L221	40.748	2.85	No	No	0	5	4
44	R:R:L221	R:R:V236	39.5332	5.96	No	No	0	4	5
45	R:R:L220	R:R:V236	38.2902	2.98	Yes	No	0	7	5
46	R:R:L220	R:R:V125	25.748	2.98	Yes	No	0	7	8
47	R:R:T216	R:R:V125	24.5613	4.76	No	No	0	8	8
48	R:R:F122	R:R:T216	23.2115	2.59	Yes	No	0	8	8
49	R:R:F122	R:R:Y127	16.1417	9.28	Yes	Yes	6	8	6
50	R:R:S131	R:R:Y127	11.9629	2.54	Yes	Yes	0	6	6
51	L:L:?1	R:R:Y165	15.4893	inf	Yes	Yes	1	0	1
52	L:L:?1	R:R:W190	10.1912	inf	Yes	No	0	0	3
53	R:R:F206	R:R:F246	23.4252	6.43	Yes	Yes	0	7	9
54	R:R:L220	R:R:R232	11.6423	1.21	Yes	Yes	0	7	7
55	L:L:?1	R:R:L265	11.6029	inf	Yes	No	0	0	1
56	R:R:F266	R:R:L265	10.1912	9.74	No	No	0	2	1

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D10	inf	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:T13	inf	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y104	inf	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y108	inf	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y165	inf	1	Yes	Yes	0	1	0	1
L:L:?1	R:R:F176	inf	1	Yes	No	0	4	0	1
L:L:?1	R:R:V178	inf	1	Yes	No	0	3	0	1
L:L:?1	R:R:L179	inf	1	Yes	No	0	4	0	1
L:L:?1	R:R:W181	inf	1	Yes	No	0	2	0	1
L:L:?1	R:R:W190	inf	1	Yes	No	0	3	0	1
L:L:?1	R:R:L194	inf	1	Yes	No	0	5	0	1
L:L:?1	R:R:I197	inf	1	Yes	No	0	5	0	1
L:L:?1	R:R:L257	inf	1	Yes	No	0	6	0	1
L:L:?1	R:R:H260	inf	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:I261	inf	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:R264	inf	1	Yes	No	0	3	0	1
L:L:?1	R:R:L265	inf	1	Yes	No	0	1	0	1
L:L:?1	R:R:Y272	inf	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:Y275	inf	1	Yes	Yes	0	5	0	1
R:R:D10	R:R:T13	8.67	1	Yes	No	7	7	1	1
R:R:D10	R:R:R264	10.72	1	Yes	No	7	3	1	1
R:R:M16	R:R:Y272	5.99	0	No	Yes	6	4	2	1
R:R:F103	R:R:Y104	10.32	0	Yes	Yes	6	5	2	1
R:R:F103	R:R:L279	7.31	0	Yes	No	6	5	2	2
R:R:Y104	R:R:Y108	6.95	1	Yes	No	5	7	1	1
R:R:F176	R:R:Y104	6.19	1	No	Yes	4	5	1	1
R:R:Y104	R:R:Y275	4.96	1	Yes	Yes	5	5	1	1
R:R:L201	R:R:Y108	7.03	0	Yes	No	5	7	2	1
R:R:V178	R:R:Y165	7.57	1	No	Yes	3	1	1	1
R:R:K180	R:R:Y165	4.78	0	No	Yes	3	1	2	1
R:R:L184	R:R:W190	12.53	0	No	No	1	3	2	1
R:R:F193	R:R:I197	11.3	0	No	No	6	5	2	1
R:R:I261	R:R:L194	7.14	1	Yes	No	5	5	1	1
R:R:F195	R:R:I261	5.02	0	No	Yes	5	5	2	1
R:R:I197	R:R:L201	4.28	0	No	Yes	5	5	1	2
R:R:N253	R:R:Y275	11.63	1	Yes	Yes	7	5	2	1
R:R:L279	R:R:N253	6.87	1	No	Yes	5	7	2	2
R:R:I261	R:R:L257	7.14	1	Yes	No	5	6	1	1
R:R:L257	R:R:Y275	9.38	1	No	Yes	6	5	1	1
R:R:H260	R:R:R264	4.51	1	Yes	No	4	3	1	1
R:R:H260	R:R:S270	6.97	1	Yes	No	4	4	1	2
R:R:H260	R:R:Y272	10.89	1	Yes	Yes	4	4	1	1
R:R:F266	R:R:L265	9.74	0	No	No	2	1	2	1
R:R:K276	R:R:Y272	13.14	0	No	Yes	4	4	2	1
R:R:L279	R:R:Y275	7.03	1	No	Yes	5	5	2	1
R:R:P9	R:R:Y165	4.17	0	Yes	Yes	5	1	2	1
R:R:P166	R:R:Y165	4.17	0	No	Yes	3	1	2	1
R:R:F176	R:R:T100	3.89	1	No	No	4	5	1	2
R:R:V187	R:R:W181	2.45	0	No	No	3	2	2	1
R:R:A12	R:R:D10	1.54	0	No	Yes	4	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9ECJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.23
Number of Linked Nodes	279
Number of Links	306
Number of Hubs	39
Number of Links mediated by Hubs	155
Number of Communities	9
Number of Nodes involved in Communities	50
Number of Links involved in Communities	66

Path Summary
Number Of Nodes in MetaPath	57
Number Of Links MetaPath	56
Number of Shortest Paths	35756
Length Of Smallest Path	3
Average Path Length	14.2765
Length of Longest Path	37
Minimum Path Strength	1.33
Average Path Strength	inf
Maximum Path Strength	inf
Minimum Path Correlation	0.7
Average Path Correlation	0.925084
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	51.5548
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.2549
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • D5 dopamine receptor binding • dopamine receptor binding • GTPase regulator activity • enzyme regulator activity • guanyl-nucleotide exchange factor activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • multicellular organismal process • system process • circulatory system process • regulation of blood pressure • biological regulation • regulation of biological quality • blood circulation • developmental process • cellular developmental process • cell differentiation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of cell motility • regulation of fibroblast migration • fibroblast migration • regulation of locomotion • ameboidal-type cell migration • regulation of cell migration • cell migration • cell motility • locomotion • multicellular organism development • embryo development ending in birth or egg hatching • chordate embryonic development • anatomical structure development • embryo development • in utero embryonic development • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of developmental process • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • regulation of anatomical structure morphogenesis • regulation of body fluid levels • wound healing • cell activation • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • platelet activation • branching morphogenesis of an epithelial tube • angiogenesis • tube morphogenesis • epithelial tube morphogenesis • blood vessel development • system development • epithelium development • blood vessel morphogenesis • tube development • morphogenesis of an epithelium • tissue development • vasculature development • circulatory system development • branching involved in blood vessel morphogenesis • tissue morphogenesis • morphogenesis of a branching structure • anatomical structure formation involved in morphogenesis • morphogenesis of a branching epithelium • regulation of cellular component organization • cellular component organization • cellular component biogenesis • cellular component assembly • regulation of postsynapse assembly • cell junction assembly • regulation of synapse structure or activity • synapse organization • cellular component organization or biogenesis • regulation of synapse assembly • postsynapse organization • postsynapse assembly • regulation of postsynapse organization • nervous system development • regulation of cellular component biogenesis • regulation of cell junction assembly • regulation of synapse organization • cell junction organization • synapse assembly • Rho-activating G protein-coupled receptor signaling pathway • regulation of signaling • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • regulation of signal transduction • intracellular signal transduction • regulation of intracellular signal transduction • regulation of response to stimulus • intracellular signaling cassette • regulation of cell communication • Rho protein signal transduction • anchoring junction • focal adhesion • cell-substrate junction • pigment granule • intracellular vesicle • melanosome • cytoplasmic vesicle • brush border membrane • cluster of actin-based cell projections • brush border • apical part of cell • plasma membrane region • apical plasma membrane • cell projection membrane • postsynapse • nucleus • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • G protein-coupled purinergic nucleotide receptor activity • purinergic nucleotide receptor activity • nucleotide receptor activity
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q86VZ1
Sequence	>9ECJ_nogp_Chain_R G P D N A T L Q M L R N P A I A V A L P V V Y S L V A A V S I P G N L F S L W V L C R R M G P R S P S V I F M I N L S V T D L M L A S V L P F Q I Y Y H C N R H H W V F G V L L C N V V T V A F Y A N M Y S S I L T M T C I S V E R F L G V L Y P L S S K R W R R R R Y A V A A C A G T W L L L L T A L S P L A R T D L T Y P V H A L G I I T C F D V L K W T M L P S V A M W A V F L F T I F I L L F L I P F V I T V A C Y T A T I L K L L R T E E A H G R E Q R R R A V G L A A V V L L A F V T C F A P N N F V L L A H I V S R L F Y G K S Y Y H V Y K L T L C L S C L N N C L D P F V Y Y F A S R E F Q L R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9ECJ	A	Nucleotide	P2Y	P2Y8	Homo sapiens	S-geranylgeranyl-L-glutathione	-	G13/β1/γ2	2.9	2025-11-05	To be published
	9ECJ (No Gprot)	A	Nucleotide	P2Y	P2Y8	Homo sapiens	S-geranylgeranyl-L-glutathione	-		2.9	2025-11-05	To be published

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