psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:D1	R:R:M242	4.16	No	No	0	0	1
2	L:L:L23	L:L:V2	10.43	Yes	No	0	0	0
3	L:L:L23	L:L:L3	15.22	Yes	No	0	0	0
4	L:L:L3	R:R:V241	5.96	No	No	0	0	2
5	L:L:E19	L:L:L6	17.23	No	Yes	0	0	0
6	L:L:I20	L:L:L6	4.28	No	Yes	0	0	0
7	L:L:L23	L:L:L6	4.15	Yes	Yes	0	0	0
8	L:L:L6	N:N:F14	6.09	Yes	No	0	0	0
9	L:L:S7	N:N:C10	5.16	No	No	0	0	0
10	L:L:S7	N:N:F14	14.53	No	No	0	0	0
11	L:L:C10	L:L:C15	7.28	No	No	0	0	0
12	L:L:C10	N:N:F14	4.19	No	No	0	0	0
13	L:L:C11	N:N:L9	6.35	No	No	0	0	0
14	L:L:C11	N:N:C10	7.28	No	No	0	0	0
15	L:L:S16	L:L:S18	4.89	No	No	0	0	0
16	L:L:I20	L:L:K17	4.36	No	No	0	0	0
17	L:L:C24	N:N:C22	7.28	No	No	0	0	0
18	L:L:C24	R:R:R250	5.57	No	No	0	0	3
19	N:N:E13	N:N:G11	4.91	No	No	0	0	0
20	N:N:I15	N:N:R12	6.26	No	No	0	0	0
21	N:N:R12	R:R:D145	8.34	No	No	0	0	3
22	N:N:R12	R:R:E244	8.14	No	No	0	0	2
23	N:N:I15	N:N:V18	4.61	No	No	0	0	0
24	N:N:R16	R:R:D145	10.72	No	No	4	0	3
25	N:N:R16	R:R:F146	10.69	No	Yes	4	0	4
26	N:N:I19	R:R:F146	8.79	No	Yes	0	0	4
27	N:N:I19	R:R:L246	8.56	No	No	0	0	4
28	N:N:F20	N:N:R26	9.62	Yes	No	3	0	0
29	N:N:F20	R:R:F364	4.29	Yes	No	0	0	1
30	N:N:F20	R:R:Q367	11.71	Yes	Yes	3	0	4
31	N:N:F20	R:R:V368	3.93	Yes	No	0	0	4
32	N:N:T21	R:R:K353	9.01	No	No	0	0	3
33	N:N:C22	R:R:W263	5.22	No	Yes	0	0	3
34	N:N:S25	R:R:W138	4.94	No	Yes	0	0	7
35	N:N:S25	R:R:E141	7.19	No	No	0	0	6
36	N:N:R26	R:R:Q367	9.35	No	Yes	3	0	4
37	N:N:R26	R:R:F371	27.79	No	Yes	3	0	4
38	N:N:W27	R:R:T162	8.49	Yes	No	0	0	7
39	N:N:W27	R:R:H268	4.23	Yes	No	0	0	5
40	N:N:W27	R:R:K271	10.44	Yes	Yes	0	0	5
41	N:N:W27	R:R:V375	7.36	Yes	No	0	0	6
42	R:R:E77	R:R:Y369	4.49	No	No	0	1	1
43	R:R:I82	R:R:R79	11.27	No	No	0	5	3
44	R:R:I84	R:R:V87	4.61	No	No	0	6	5
45	R:R:I84	R:R:Y88	6.04	No	Yes	0	6	8
46	R:R:I84	R:R:N142	4.25	No	No	0	6	6
47	R:R:S85	R:R:W89	8.65	Yes	No	0	5	5
48	R:R:L135	R:R:Y88	11.72	No	Yes	0	8	8
49	R:R:A139	R:R:Y88	4	No	Yes	0	7	8
50	R:R:V375	R:R:Y88	5.05	No	Yes	0	6	8
51	R:R:A139	R:R:W89	3.89	No	No	0	7	5
52	R:R:C92	R:R:L135	4.76	No	No	0	7	8
53	R:R:C92	R:R:P136	5.65	No	No	0	7	9
54	R:R:F129	R:R:L96	7.31	No	No	0	7	6
55	R:R:L133	R:R:L96	4.15	No	No	0	4	6
56	R:R:D128	R:R:N99	10.77	No	No	0	9	9
57	R:R:F129	R:R:N99	9.67	No	No	0	7	9
58	R:R:N99	R:R:P386	4.89	No	No	0	9	9
59	R:R:L100	R:R:Y104	7.03	No	No	0	4	4
60	R:R:F129	R:R:L100	6.09	No	No	0	7	4
61	R:R:P386	R:R:V102	5.3	No	Yes	0	9	9
62	R:R:C390	R:R:V102	6.83	No	Yes	0	7	9
63	R:R:L391	R:R:V102	4.47	No	Yes	0	7	9
64	R:R:S108	R:R:Y104	7.63	No	No	0	4	4
65	R:R:L105	R:R:L400	11.07	No	No	0	8	6
66	R:R:K107	R:R:M106	4.32	Yes	No	1	4	6
67	R:R:M106	R:R:T122	4.52	No	Yes	1	6	4
68	R:R:F396	R:R:M106	8.71	Yes	No	1	9	6
69	R:R:K107	R:R:R113	4.95	Yes	No	0	4	7
70	R:R:K107	R:R:T122	4.5	Yes	Yes	1	4	4
71	R:R:L403	R:R:M109	4.24	Yes	No	0	4	4
72	R:R:Q110	R:R:W112	5.48	No	Yes	0	5	5
73	R:R:K398	R:R:Q110	5.42	No	No	0	5	5
74	R:R:A399	R:R:Q110	4.55	No	No	0	6	5
75	R:R:E395	R:R:W112	17.45	No	Yes	1	5	5
76	R:R:F396	R:R:W112	5.01	Yes	Yes	1	9	5
77	R:R:N118	R:R:S115	8.94	No	No	0	8	7
78	R:R:S116	R:R:T179	4.8	No	No	0	7	8
79	R:R:I117	R:R:M176	4.37	No	No	0	8	9
80	R:R:I117	R:R:T179	4.56	No	No	0	8	8
81	R:R:I117	R:R:R393	5.01	No	No	0	8	8
82	R:R:N118	R:R:R393	4.82	No	No	0	8	8
83	R:R:L119	R:R:T122	4.42	No	Yes	1	6	4
84	R:R:L119	R:R:N123	9.61	No	No	1	6	9
85	R:R:A175	R:R:F120	4.16	No	No	0	7	8
86	R:R:F120	R:R:T179	5.19	No	No	0	8	8
87	R:R:M176	R:R:V121	4.56	No	No	0	9	8
88	R:R:N123	R:R:T122	5.85	No	Yes	1	9	4
89	R:R:F172	R:R:N123	10.87	No	No	0	8	9
90	R:R:D128	R:R:L124	4.07	No	No	0	9	9
91	R:R:L124	R:R:L173	6.92	No	No	6	9	9
92	R:R:L124	R:R:N385	4.12	No	No	6	9	9
93	R:R:N165	R:R:T127	4.39	Yes	No	0	8	8
94	R:R:A168	R:R:T127	5.03	No	No	7	7	8
95	R:R:T127	R:R:W222	7.28	No	Yes	7	8	9
96	R:R:D128	R:R:S382	4.42	No	No	0	9	9
97	R:R:N165	R:R:Q130	18.49	Yes	No	0	8	7
98	R:R:F131	R:R:N165	9.67	No	Yes	0	7	8
99	R:R:F131	R:R:H379	30.55	No	No	0	7	7
100	R:R:F131	R:R:S382	6.61	No	No	0	7	9
101	R:R:H379	R:R:V132	4.15	No	No	0	7	7
102	R:R:T134	R:R:W138	6.06	No	Yes	0	7	7
103	R:R:T134	R:R:V161	7.93	No	No	0	7	5
104	R:R:F137	R:R:V158	7.87	No	No	0	6	6
105	R:R:V158	R:R:W138	6.13	No	Yes	0	6	7
106	R:R:T162	R:R:W138	7.28	No	Yes	0	7	7
107	R:R:E141	R:R:F146	4.66	No	Yes	0	6	4
108	R:R:E141	R:R:W148	6.54	No	Yes	0	6	9
109	R:R:K147	R:R:L144	11.28	No	No	0	5	5
110	R:R:D145	R:R:F146	4.78	No	Yes	4	3	4
111	R:R:E244	R:R:K147	14.85	No	No	0	2	5
112	R:R:F150	R:R:W148	12.03	Yes	Yes	0	7	9
113	R:R:C155	R:R:W148	6.53	No	Yes	8	9	9
114	R:R:C247	R:R:W148	9.14	No	Yes	8	9	9
115	R:R:F150	R:R:P149	7.22	Yes	No	0	7	3
116	R:R:F150	R:R:M154	9.95	Yes	No	0	7	6
117	R:R:K152	R:R:T238	4.5	No	No	0	3	5
118	R:R:C155	R:R:C247	7.28	No	No	8	9	9
119	R:R:A233	R:R:K156	4.82	No	No	0	5	7
120	R:R:S159	R:R:S232	6.52	No	No	0	6	4
121	R:R:A233	R:R:M160	4.83	No	No	0	5	6
122	R:R:N165	R:R:V161	5.91	Yes	No	0	8	5
123	R:R:S163	R:R:Y167	3.82	No	Yes	0	4	6
124	R:R:A226	R:R:M164	4.83	No	No	0	3	5
125	R:R:M164	R:R:S229	6.13	No	No	0	5	7
126	R:R:K271	R:R:M166	8.64	Yes	No	2	5	8
127	R:R:M166	R:R:W339	5.82	No	Yes	2	8	9
128	R:R:M166	R:R:Q343	4.08	No	Yes	2	8	8
129	R:R:F171	R:R:Y167	5.16	No	Yes	0	5	6
130	R:R:A228	R:R:Y167	5.34	No	Yes	0	5	6
131	R:R:Q270	R:R:Y167	5.64	No	Yes	0	3	6
132	R:R:A168	R:R:W222	3.89	No	Yes	7	7	9
133	R:R:F335	R:R:V170	6.55	No	No	0	9	8
134	R:R:F171	R:R:I221	5.02	No	No	0	5	7
135	R:R:F171	R:R:L274	4.87	No	No	0	5	5
136	R:R:F172	R:R:I221	12.56	No	No	0	8	7
137	R:R:F172	R:R:W222	8.02	No	Yes	0	8	9
138	R:R:L173	R:R:N385	9.61	No	No	6	9	9
139	R:R:L173	R:R:Y389	4.69	No	Yes	0	9	9
140	R:R:P279	R:R:T174	5.25	No	No	0	9	7
141	R:R:I282	R:R:T174	6.08	No	No	0	7	7
142	R:R:I283	R:R:T174	4.56	No	No	0	8	7
143	R:R:M176	R:R:Y389	7.18	No	Yes	0	9	9
144	R:R:I283	R:R:S177	4.64	No	No	0	8	9
145	R:R:S177	R:R:Y287	15.26	No	Yes	0	9	9
146	R:R:R180	R:R:Y287	8.23	No	Yes	0	9	9
147	R:R:R180	R:R:Y389	5.14	No	Yes	0	9	9
148	R:R:A185	R:R:Y181	4	No	No	0	7	8
149	R:R:C286	R:R:Y181	4.03	No	No	0	7	8
150	R:R:L289	R:R:Y181	12.89	No	No	0	5	8
151	R:R:H182	R:R:S186	4.18	No	No	0	5	6
152	R:R:L290	R:R:V184	4.47	No	No	0	8	8
153	R:R:K189	R:R:R192	8.66	No	No	0	5	4
154	R:R:H191	R:R:S190	13.95	No	No	0	5	6
155	R:R:R192	R:R:T193	10.35	No	No	0	4	4
156	R:R:C211	R:R:L217	4.76	No	No	0	5	5
157	R:R:F212	R:R:S213	7.93	No	No	0	7	4
158	R:R:L224	R:R:W220	9.11	No	No	0	4	4
159	R:R:P231	R:R:Y267	4.17	No	Yes	0	8	6
160	R:R:S232	R:R:Y267	5.09	No	Yes	0	4	6
161	R:R:F235	R:R:I234	8.79	No	No	0	5	4
162	R:R:F235	R:R:F251	31.08	No	Yes	0	5	5
163	R:R:F235	R:R:P252	4.33	No	No	0	5	6
164	R:R:L248	R:R:V239	8.94	No	No	0	4	2
165	R:R:E245	R:R:K240	16.2	No	No	0	4	1
166	R:R:P252	R:R:R250	4.32	No	No	0	6	3
167	R:R:F251	R:R:R260	11.76	Yes	No	0	5	5
168	R:R:F251	R:R:Y267	5.16	Yes	Yes	0	5	6
169	R:R:D253	R:R:L255	8.14	No	No	0	1	2
170	R:R:L255	R:R:L256	4.15	No	No	0	2	3
171	R:R:R258	R:R:W263	6	No	Yes	0	4	3
172	R:R:D259	R:R:W263	8.93	No	Yes	5	4	3
173	R:R:D259	R:R:L264	4.07	No	No	5	4	4
174	R:R:L266	R:R:Q261	6.65	No	No	0	3	1
175	R:R:L264	R:R:W263	7.97	No	Yes	5	4	3
176	R:R:K353	R:R:W263	19.73	No	Yes	0	3	3
177	R:R:L266	R:R:S269	4.5	No	No	0	3	4
178	R:R:H268	R:R:Y267	6.53	No	Yes	0	5	6
179	R:R:Q270	R:R:Y267	5.64	No	Yes	0	3	6
180	R:R:H268	R:R:T346	4.11	No	No	0	5	5
181	R:R:K271	R:R:N342	4.2	Yes	Yes	2	5	7
182	R:R:K271	R:R:Q343	12.2	Yes	Yes	2	5	8
183	R:R:K271	R:R:T346	7.51	Yes	No	2	5	5
184	R:R:Q343	R:R:V272	4.3	Yes	No	0	8	7
185	R:R:T347	R:R:V272	4.76	No	No	0	6	7
186	R:R:G275	R:R:P279	4.06	No	No	0	6	9
187	R:R:F276	R:R:Q343	9.37	No	Yes	0	8	8
188	R:R:L278	R:R:P279	4.93	No	No	0	6	9
189	R:R:I282	R:R:L278	4.28	No	No	0	7	6
190	R:R:F336	R:R:L280	4.87	No	No	0	6	6
191	R:R:V328	R:R:Y287	8.83	No	Yes	0	7	9
192	R:R:T325	R:R:V291	6.35	No	No	0	6	5
193	R:R:F293	R:R:R297	5.34	No	No	0	5	5
194	R:R:I294	R:R:R320	6.26	No	No	0	8	5
195	R:R:R298	R:R:S317	3.95	No	No	0	2	4
196	R:R:R298	R:R:R320	5.33	No	No	0	2	5
197	R:R:R312	R:R:S317	7.91	No	No	0	2	4
198	R:R:G315	R:R:R319	7.51	No	No	0	4	4
199	R:R:L321	R:R:R320	4.86	No	No	0	6	5
200	R:R:V331	R:R:Y389	6.31	No	Yes	0	8	9
201	R:R:F335	R:R:W339	4.01	No	Yes	0	9	9
202	R:R:F336	R:R:L340	9.74	No	No	0	6	5
203	R:R:C338	R:R:N381	4.72	No	No	0	9	9
204	R:R:N342	R:R:W339	6.78	Yes	Yes	2	7	9
205	R:R:Q343	R:R:W339	7.67	Yes	Yes	2	8	9
206	R:R:A378	R:R:W339	7.78	No	Yes	2	7	9
207	R:R:N381	R:R:W339	4.52	No	Yes	0	9	9
208	R:R:N342	R:R:S374	4.47	Yes	No	0	7	6
209	R:R:A378	R:R:N342	4.69	No	Yes	2	7	7
210	R:R:Q343	R:R:T346	4.25	Yes	No	2	8	5
211	R:R:C366	R:R:L345	4.76	No	No	0	3	4
212	R:R:L345	R:R:Q367	5.32	No	Yes	0	4	4
213	R:R:I352	R:R:W348	5.87	No	Yes	9	3	5
214	R:R:W348	R:R:Y363	3.86	Yes	No	9	5	3
215	R:R:Q367	R:R:S349	5.78	Yes	No	0	4	4
216	R:R:F354	R:R:I350	7.54	Yes	No	0	2	5
217	R:R:I352	R:R:Y363	8.46	No	No	9	3	3
218	R:R:F359	R:R:K353	4.96	No	No	0	3	3
219	R:R:F359	R:R:V357	3.93	No	No	0	3	4
220	R:R:F359	R:R:Y363	10.32	No	No	0	3	3
221	R:R:E362	R:R:S360	4.31	No	No	0	3	5
222	R:R:F364	R:R:Q361	9.37	No	No	0	1	5
223	R:R:L365	R:R:Q361	13.31	No	No	0	2	5
224	R:R:F371	R:R:Q367	10.54	Yes	Yes	3	4	4
225	R:R:V368	R:R:Y369	12.62	No	No	0	4	1
226	R:R:F371	R:R:P372	4.33	Yes	No	0	4	5
227	R:R:F371	R:R:V375	3.93	Yes	No	0	4	6
228	R:R:N381	R:R:N385	12.26	No	No	0	9	9
229	R:R:L391	R:R:V387	5.96	No	No	0	7	7
230	R:R:C390	R:R:F396	5.59	No	Yes	0	7	9
231	R:R:F396	R:R:R393	6.41	Yes	No	0	9	8
232	R:R:R394	R:R:R397	6.4	No	No	0	5	8
233	R:R:E395	R:R:F396	9.33	No	Yes	1	5	9
234	R:R:E395	R:R:K398	4.05	No	No	0	5	5
235	R:R:I407	R:R:L403	4.28	No	Yes	0	3	4
236	R:R:V332	R:R:Y287	3.79	No	Yes	0	8	9
237	L:L:G5	L:L:S8	3.71	No	No	0	0	0
238	R:R:F276	R:R:L340	3.65	No	No	0	8	5
239	R:R:F335	R:R:L280	3.65	No	No	0	9	6
240	R:R:L255	R:R:R260	3.64	No	No	0	2	5
241	R:R:P313	R:R:S317	3.56	No	No	0	3	4
242	R:R:P341	R:R:S374	3.56	No	No	0	9	6
243	R:R:G243	R:R:K240	3.49	No	No	0	6	1
244	R:R:C286	R:R:S177	3.44	No	No	0	7	9
245	R:R:L126	R:R:W222	3.42	No	Yes	0	5	9
246	R:R:C286	R:R:V178	3.42	No	No	0	7	6
247	R:R:A216	R:R:S213	3.42	No	No	0	2	4
248	R:R:L217	R:R:W220	3.42	No	No	0	5	4
249	R:R:C218	R:R:V219	3.42	No	No	0	7	4
250	R:R:S163	R:R:S229	3.26	No	No	0	4	7
251	L:L:A4	R:R:M242	3.22	No	No	0	0	1
252	R:R:V291	R:R:V328	3.21	No	No	0	5	7
253	R:R:S186	R:R:T193	3.2	No	No	0	6	4
254	L:L:C24	R:R:L248	3.17	No	No	0	0	4
255	R:R:C383	R:R:L94	3.17	No	No	0	8	6
256	R:R:C218	R:R:L119	3.17	No	No	0	7	6
257	R:R:M160	R:R:S229	3.07	No	No	0	6	7
258	R:R:I294	R:R:V184	3.07	No	No	0	8	8
259	R:R:I284	R:R:V332	3.07	No	No	0	4	8
260	R:R:K156	R:R:S236	3.06	No	No	0	7	5
261	R:R:F354	R:R:G265	3.01	Yes	No	0	2	3
262	R:R:L384	R:R:S334	3	No	No	0	6	6
263	R:R:L377	R:R:S380	3	No	No	0	7	5
264	R:R:L135	R:R:V91	2.98	No	No	0	8	7
265	R:R:L273	R:R:V277	2.98	No	No	0	4	4
266	R:R:L388	R:R:V387	2.98	No	No	0	7	7
267	R:R:L333	R:R:T329	2.95	No	No	0	5	5
268	R:R:I157	R:R:M154	2.92	No	No	0	4	6
269	R:R:E77	R:R:V80	2.85	No	No	0	1	5
270	R:R:K189	R:R:L188	2.82	No	No	0	5	6
271	R:R:A78	R:R:R79	2.77	No	No	0	3	3
272	R:R:L285	R:R:L289	2.77	No	No	0	4	5
273	R:R:F150	R:R:V140	2.62	Yes	No	0	7	5
274	R:R:F251	R:R:V249	2.62	Yes	No	0	5	5
275	R:R:F276	R:R:V277	2.62	No	No	0	8	4
276	R:R:I82	R:R:R81	2.51	No	No	0	5	4
277	R:R:K254	R:R:R258	2.48	No	No	0	3	4
278	R:R:F212	R:R:L217	2.44	No	No	0	7	5
279	R:R:F336	R:R:L337	2.44	No	No	0	6	5
280	R:R:L403	R:R:R406	2.43	Yes	No	0	4	4
281	R:R:K114	R:R:W112	2.32	No	Yes	0	6	5
282	R:R:L351	R:R:W348	2.28	No	Yes	0	4	5
283	R:R:L404	R:R:W405	2.28	No	No	0	6	4
284	N:N:G23	N:N:G24	2.11	No	No	0	0	0
285	R:R:F354	R:R:W263	2	Yes	Yes	0	2	3
286	N:N:G24	R:R:C247	1.96	No	No	0	0	9
287	R:R:C383	R:R:G95	1.96	No	No	0	8	8
288	L:L:A4	L:L:G5	1.95	No	No	0	0	0
289	R:R:A97	R:R:G98	1.95	No	No	0	4	8
290	R:R:A316	R:R:P313	1.87	No	No	0	4	3
291	R:R:G95	R:R:V132	1.84	No	No	0	8	7
292	R:R:A168	R:R:A225	1.79	No	No	0	7	8
293	R:R:P358	R:R:S360	1.78	No	No	0	1	5
294	R:R:G151	R:R:M154	1.75	No	No	0	8	6
295	R:R:G111	R:R:K107	1.74	No	Yes	0	5	4
296	R:R:C338	R:R:S334	1.72	No	No	0	9	6
297	R:R:C338	R:R:S380	1.72	No	No	0	9	5
298	R:R:A143	R:R:S85	1.71	No	Yes	0	5	5
299	R:R:C376	R:R:V91	1.71	No	No	0	6	7
300	R:R:G98	R:R:L101	1.71	No	No	0	8	7
301	R:R:A214	R:R:S116	1.71	No	No	0	7	7
302	R:R:A125	R:R:V102	1.7	No	Yes	0	9	9
303	R:R:A344	R:R:T347	1.68	No	No	0	6	6
304	R:R:L230	R:R:P231	1.64	No	No	0	4	8
305	R:R:E244	R:R:G243	1.64	No	No	0	2	6
306	R:R:S85	R:R:V86	1.62	Yes	No	0	5	5
307	R:R:S169	R:R:V170	1.62	No	No	0	9	8
308	R:R:C218	R:R:K215	1.62	No	No	0	7	3
309	R:R:A153	R:R:K156	1.61	No	No	0	2	7
310	R:R:V86	R:R:V90	1.6	No	No	0	5	4
311	R:R:V239	R:R:V241	1.6	No	No	0	2	2
312	R:R:V291	R:R:V324	1.6	No	No	0	5	8
313	R:R:T329	R:R:V328	1.59	No	No	0	5	7
314	R:R:A125	R:R:L103	1.58	No	No	0	9	7
315	R:R:A295	R:R:L321	1.58	No	No	0	4	6
316	R:R:A299	R:R:L321	1.58	No	No	0	4	6
317	R:R:A370	R:R:L345	1.58	No	No	0	4	4
318	R:R:I82	R:R:S85	1.55	No	Yes	0	5	5
319	R:R:I350	R:R:S269	1.55	No	No	0	5	4
320	R:R:I330	R:R:S327	1.55	No	No	0	6	8
321	R:R:I330	R:R:V331	1.54	No	No	0	6	8
322	R:R:K215	R:R:S213	1.53	No	No	0	3	4
323	N:N:C10	N:N:E13	1.52	No	No	0	0	0
324	L:L:L23	L:L:S22	1.5	Yes	No	0	0	0
325	N:N:G11	N:N:R8	1.5	No	No	0	0	0
326	R:R:L290	R:R:V324	1.49	No	No	0	8	8
327	R:R:L377	R:R:V373	1.49	No	No	0	7	5
328	R:R:I330	R:R:K326	1.45	No	No	0	6	7
329	L:L:E19	L:L:S9	1.44	No	No	0	0	0
330	L:L:L3	R:R:M242	1.41	No	No	0	0	1
331	L:L:G14	L:L:W13	1.41	No	No	0	0	0
332	R:R:E245	R:R:T238	1.41	No	No	0	4	5
333	R:R:K401	R:R:L400	1.41	No	No	0	4	6
334	R:R:L105	R:R:L391	1.38	No	No	0	8	7
335	R:R:L105	R:R:L403	1.38	No	Yes	0	8	4
336	R:R:L227	R:R:L230	1.38	No	No	0	4	4
337	R:R:A318	R:R:R312	1.38	No	No	0	3	2
338	L:L:S21	R:R:R258	1.32	No	No	0	0	4
339	R:R:F293	R:R:V184	1.31	No	No	0	5	8
340	R:R:R250	R:R:T237	1.29	No	No	0	3	4
341	R:R:K323	R:R:R319	1.24	No	No	0	7	4
342	R:R:L188	R:R:R297	1.21	No	No	0	6	5
343	R:R:F354	R:R:N355	1.21	Yes	No	0	2	4
344	R:R:F262	R:R:Q261	1.17	No	No	0	1	1
345	R:R:E362	R:R:W348	1.09	No	Yes	0	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:L6	7.9375	4	0	0
2	L:L:L23	7.825	4	0	0
3	N:N:F20	7.3875	4	3	0
4	N:N:W27	7.63	4	0	0
5	R:R:S85	3.3825	4	0	5
6	R:R:Y88	6.7025	4	0	8
7	R:R:V102	4.575	4	0	9
8	R:R:K107	3.8775	4	1	4
9	R:R:W112	7.565	4	1	5
10	R:R:T122	4.8225	4	1	4
11	R:R:W138	6.1025	4	0	7
12	R:R:F146	7.23	4	4	4
13	R:R:W148	8.56	4	8	9
14	R:R:F150	7.955	4	0	7
15	R:R:N165	9.615	4	0	8
16	R:R:Y167	4.99	4	0	6
17	R:R:W222	5.6525	4	7	9
18	R:R:F251	12.655	4	0	5
19	R:R:W263	8.30833	6	5	3
20	R:R:Y267	5.318	5	0	6
21	R:R:K271	8.598	5	2	5
22	R:R:Y287	9.0275	4	0	9
23	R:R:W339	6.09667	6	2	9
24	R:R:N342	5.035	4	2	7
25	R:R:Q343	6.97833	6	2	8
26	R:R:W348	3.275	4	9	5
27	R:R:F354	3.44	4	0	2
28	R:R:Q367	8.54	5	3	4
29	R:R:F371	11.6475	4	3	4
30	R:R:Y389	5.83	4	0	9
31	R:R:F396	7.01	5	1	9
32	R:R:L403	3.0825	4	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:L23	L:L:L3	19.3203	15.22	Yes	No	0	0	0
2	L:L:L3	R:R:V241	25.2873	5.96	No	No	0	0	2
3	L:L:L23	L:L:L6	16.2479	4.15	Yes	Yes	0	0	0
4	L:L:L6	N:N:F14	10.9955	6.09	Yes	No	0	0	0
5	L:L:C24	R:R:L248	28.1819	3.17	No	No	0	0	4
6	R:R:L248	R:R:V239	27.2236	8.94	No	No	0	4	2
7	R:R:V239	R:R:V241	26.2588	1.6	No	No	0	2	2
8	L:L:C24	N:N:C22	27.2236	7.28	No	No	0	0	0
9	L:L:C24	R:R:R250	51.5658	5.57	No	No	0	0	3
10	R:R:P252	R:R:R250	53.107	4.32	No	No	0	6	3
11	R:R:F235	R:R:P252	53.8677	4.33	No	No	0	5	6
12	R:R:F235	R:R:F251	55.3693	31.08	No	Yes	0	5	5
13	R:R:F251	R:R:Y267	59.7161	5.16	Yes	Yes	0	5	6
14	R:R:H268	R:R:Y267	62.4988	6.53	No	Yes	0	5	6
15	N:N:W27	R:R:H268	30.9086	4.23	Yes	No	0	0	5
16	N:N:W27	R:R:T162	45.365	8.49	Yes	No	0	0	7
17	R:R:T162	R:R:W138	44.4364	7.28	No	Yes	0	7	7
18	N:N:S25	R:R:W138	47.2915	4.94	No	Yes	0	0	7
19	N:N:S25	R:R:E141	45.747	7.19	No	No	0	0	6
20	R:R:E141	R:R:F146	26.7	4.66	No	Yes	0	6	4
21	R:R:D145	R:R:F146	20.2094	4.78	No	Yes	4	3	4
22	N:N:R12	R:R:D145	18.586	8.34	No	No	0	0	3
23	N:N:R12	R:R:E244	13.6398	8.14	No	No	0	0	2
24	N:N:W27	R:R:V375	72.154	7.36	Yes	No	0	0	6
25	R:R:F371	R:R:V375	40.9359	3.93	Yes	No	0	4	6
26	N:N:R26	R:R:F371	15.4082	27.79	No	Yes	3	0	4
27	N:N:F20	N:N:R26	13.7221	9.62	Yes	No	3	0	0
28	R:R:F371	R:R:Q367	22.2577	10.54	Yes	Yes	3	4	4
29	N:N:F20	R:R:Q367	13.8275	11.71	Yes	Yes	3	0	4
30	N:N:F20	R:R:F364	10.3797	4.29	Yes	No	0	0	1
31	N:N:F20	R:R:V368	13.8275	3.93	Yes	No	0	0	4
32	N:N:C22	R:R:W263	26.2588	5.22	No	Yes	0	0	3
33	R:R:K353	R:R:W263	12.0591	19.73	No	Yes	0	3	3
34	N:N:W27	R:R:K271	77.5908	10.44	Yes	Yes	0	0	5
35	R:R:H268	R:R:T346	32.5189	4.11	No	No	0	5	5
36	R:R:V368	R:R:Y369	10.3797	12.62	No	No	0	4	1
37	R:R:V375	R:R:Y88	32.7197	5.05	No	Yes	0	6	8
38	R:R:A139	R:R:Y88	17.5157	4	No	Yes	0	7	8
39	R:R:A139	R:R:W89	15.7935	3.89	No	No	0	7	5
40	R:R:S85	R:R:W89	14.0646	8.65	Yes	No	0	5	5
41	R:R:Q343	R:R:T346	30.2664	4.25	Yes	No	2	8	5
42	R:R:Q343	R:R:W339	53.5087	7.67	Yes	Yes	2	8	9
43	R:R:N381	R:R:W339	100	4.52	No	Yes	0	9	9
44	R:R:N381	R:R:N385	94.9287	12.26	No	No	0	9	9
45	R:R:L124	R:R:N385	20.1008	4.12	No	No	6	9	9
46	R:R:D128	R:R:L124	32.7955	4.07	No	No	0	9	9
47	R:R:D128	R:R:N99	25.1457	10.77	No	No	0	9	9
48	R:R:N99	R:R:P386	17.8384	4.89	No	No	0	9	9
49	R:R:P386	R:R:V102	16.8966	5.3	No	Yes	0	9	9
50	R:R:Q270	R:R:Y267	27.6616	5.64	No	Yes	0	3	6
51	R:R:Q270	R:R:Y167	27.082	5.64	No	Yes	0	3	6
52	R:R:F171	R:R:Y167	21.1051	5.16	No	Yes	0	5	6
53	R:R:F171	R:R:I221	20.6244	5.02	No	No	0	5	7
54	R:R:F172	R:R:I221	20.5947	12.56	No	No	0	8	7
55	R:R:F172	R:R:N123	22.4158	10.87	No	No	0	8	9
56	R:R:N123	R:R:T122	14.2754	5.85	No	Yes	1	9	4
57	R:R:M106	R:R:T122	16.0108	4.52	No	Yes	1	6	4
58	R:R:F396	R:R:M106	16.9921	8.71	Yes	No	1	9	6
59	R:R:L391	R:R:V102	17.3148	4.47	No	Yes	0	7	9
60	R:R:L105	R:R:L391	12.1777	1.38	No	No	0	8	7
61	R:R:F396	R:R:R393	15.3818	6.41	Yes	No	0	9	8
62	R:R:L173	R:R:N385	74.0936	9.61	No	No	6	9	9
63	R:R:L173	R:R:Y389	86.4162	4.69	No	Yes	0	9	9
64	R:R:M176	R:R:Y389	25.8142	7.18	No	Yes	0	9	9
65	R:R:I117	R:R:M176	23.3247	4.37	No	No	0	8	9
66	R:R:T134	R:R:W138	19.4257	6.06	No	Yes	0	7	7
67	R:R:T134	R:R:V161	19.1425	7.93	No	No	0	7	5
68	R:R:N165	R:R:V161	19.0174	5.91	Yes	No	0	8	5
69	R:R:F131	R:R:N165	16.4521	9.67	No	Yes	0	7	8
70	R:R:F131	R:R:S382	15.0887	6.61	No	No	0	7	9
71	R:R:D128	R:R:S382	15.1118	4.42	No	No	0	9	9
72	R:R:E141	R:R:W148	18.6518	6.54	No	Yes	0	6	9
73	R:R:F150	R:R:W148	10.271	12.03	Yes	Yes	0	7	9
74	R:R:K271	R:R:M166	24.8823	8.64	Yes	No	2	5	8
75	R:R:R180	R:R:Y389	70.9586	5.14	No	Yes	0	9	9
76	R:R:R180	R:R:Y287	69.5657	8.23	No	Yes	0	9	9
77	R:R:S177	R:R:Y287	23.5552	15.26	No	Yes	0	9	9
78	R:R:I283	R:R:S177	11.9373	4.64	No	No	0	8	9
79	R:R:I283	R:R:T174	10.2513	4.56	No	No	0	8	7
80	R:R:C286	R:R:S177	10.2513	3.44	No	No	0	7	9
81	R:R:V328	R:R:Y287	44.2158	8.83	No	Yes	0	7	9
82	R:R:V291	R:R:V328	39.5265	3.21	No	No	0	5	7
83	R:R:V291	R:R:V324	36.3684	1.6	No	No	0	5	8
84	R:R:L290	R:R:V324	34.8372	1.49	No	No	0	8	8
85	R:R:L290	R:R:V184	33.24	4.47	No	No	0	8	8
86	R:R:F293	R:R:V184	13.6069	1.31	No	No	0	5	8
87	R:R:F293	R:R:R297	11.934	5.34	No	No	0	5	5
88	R:R:L188	R:R:R297	10.248	1.21	No	No	0	6	5
89	R:R:C218	R:R:L119	10.8308	3.17	No	No	0	7	6
90	R:R:K271	R:R:N342	27.8296	4.2	Yes	Yes	2	5	7
91	R:R:I294	R:R:V184	18.6057	3.07	No	No	0	8	8
92	R:R:I294	R:R:R320	16.9493	6.26	No	No	0	8	5
93	R:R:R298	R:R:R320	10.248	5.33	No	No	0	2	5
94	R:R:L124	R:R:L173	13.4455	6.92	No	No	6	9	9
95	R:R:M166	R:R:W339	24.3225	5.82	No	Yes	2	8	9
96	R:R:N342	R:R:W339	25.1885	6.78	Yes	Yes	2	7	9
97	R:R:K271	R:R:Q343	26.891	12.2	Yes	Yes	2	5	8
98	R:R:I117	R:R:R393	15.9416	5.01	No	No	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:D1	R:R:M242	4.16	0	No	No	0	1	0	1
L:L:L3	R:R:V241	5.96	0	No	No	0	2	0	1
L:L:C24	R:R:R250	5.57	0	No	No	0	3	0	1
N:N:R12	R:R:D145	8.34	0	No	No	0	3	0	1
N:N:R12	R:R:E244	8.14	0	No	No	0	2	0	1
N:N:R16	R:R:D145	10.72	4	No	No	0	3	0	1
N:N:R16	R:R:F146	10.69	4	No	Yes	0	4	0	1
N:N:I19	R:R:F146	8.79	0	No	Yes	0	4	0	1
N:N:I19	R:R:L246	8.56	0	No	No	0	4	0	1
N:N:F20	R:R:F364	4.29	3	Yes	No	0	1	0	1
N:N:F20	R:R:Q367	11.71	3	Yes	Yes	0	4	0	1
N:N:F20	R:R:V368	3.93	3	Yes	No	0	4	0	1
N:N:T21	R:R:K353	9.01	0	No	No	0	3	0	1
N:N:C22	R:R:W263	5.22	0	No	Yes	0	3	0	1
N:N:S25	R:R:W138	4.94	0	No	Yes	0	7	0	1
N:N:S25	R:R:E141	7.19	0	No	No	0	6	0	1
N:N:R26	R:R:Q367	9.35	3	No	Yes	0	4	0	1
N:N:R26	R:R:F371	27.79	3	No	Yes	0	4	0	1
N:N:W27	R:R:T162	8.49	0	Yes	No	0	7	0	1
N:N:W27	R:R:H268	4.23	0	Yes	No	0	5	0	1
N:N:W27	R:R:K271	10.44	0	Yes	Yes	0	5	0	1
N:N:W27	R:R:V375	7.36	0	Yes	No	0	6	0	1
R:R:V375	R:R:Y88	5.05	0	No	Yes	6	8	1	2
R:R:T134	R:R:W138	6.06	0	No	Yes	7	7	2	1
R:R:V158	R:R:W138	6.13	0	No	Yes	6	7	2	1
R:R:T162	R:R:W138	7.28	0	No	Yes	7	7	1	1
R:R:E141	R:R:F146	4.66	0	No	Yes	6	4	1	1
R:R:E141	R:R:W148	6.54	0	No	Yes	6	9	1	2
R:R:D145	R:R:F146	4.78	4	No	Yes	3	4	1	1
R:R:E244	R:R:K147	14.85	0	No	No	2	5	1	2
R:R:C155	R:R:W148	6.53	8	No	Yes	9	9	2	2
R:R:C247	R:R:W148	9.14	8	No	Yes	9	9	1	2
R:R:C155	R:R:C247	7.28	8	No	No	9	9	2	1
R:R:K271	R:R:M166	8.64	2	Yes	No	5	8	1	2
R:R:M166	R:R:Q343	4.08	2	No	Yes	8	8	2	2
R:R:L248	R:R:V239	8.94	0	No	No	4	2	1	2
R:R:P252	R:R:R250	4.32	0	No	No	6	3	2	1
R:R:R258	R:R:W263	6	0	No	Yes	4	3	1	1
R:R:D259	R:R:W263	8.93	5	No	Yes	4	3	2	1
R:R:D259	R:R:L264	4.07	5	No	No	4	4	2	2
R:R:L264	R:R:W263	7.97	5	No	Yes	4	3	2	1
R:R:K353	R:R:W263	19.73	0	No	Yes	3	3	1	1
R:R:H268	R:R:Y267	6.53	0	No	Yes	5	6	1	2
R:R:H268	R:R:T346	4.11	0	No	No	5	5	1	2
R:R:K271	R:R:N342	4.2	2	Yes	Yes	5	7	1	2
R:R:K271	R:R:Q343	12.2	2	Yes	Yes	5	8	1	2
R:R:K271	R:R:T346	7.51	2	Yes	No	5	5	1	2
R:R:Q343	R:R:T346	4.25	2	Yes	No	8	5	2	2
R:R:L345	R:R:Q367	5.32	0	No	Yes	4	4	2	1
R:R:Q367	R:R:S349	5.78	3	Yes	No	4	4	1	2
R:R:F359	R:R:K353	4.96	0	No	No	3	3	2	1
R:R:F364	R:R:Q361	9.37	0	No	No	1	5	1	2
R:R:F371	R:R:Q367	10.54	3	Yes	Yes	4	4	1	1
R:R:V368	R:R:Y369	12.62	0	No	No	4	1	1	2
R:R:F371	R:R:P372	4.33	3	Yes	No	4	5	1	2
R:R:F371	R:R:V375	3.93	3	Yes	No	4	6	1	1
L:L:A4	R:R:M242	3.22	0	No	No	0	1	0	1
L:L:C24	R:R:L248	3.17	0	No	No	0	4	0	1
R:R:K254	R:R:R258	2.48	0	No	No	3	4	2	1
R:R:F354	R:R:W263	2	0	Yes	Yes	2	3	2	1
N:N:G24	R:R:C247	1.96	0	No	No	0	9	0	1
R:R:E244	R:R:G243	1.64	0	No	No	2	6	1	2
R:R:V239	R:R:V241	1.6	0	No	No	2	2	2	1
L:L:L3	R:R:M242	1.41	0	No	No	0	1	0	1
L:L:S21	R:R:R258	1.32	0	No	No	0	4	0	1
R:R:R250	R:R:T237	1.29	0	No	No	3	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9KFI_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.82
Number of Linked Nodes	329
Number of Links	345
Number of Hubs	32
Number of Links mediated by Hubs	125
Number of Communities	9
Number of Nodes involved in Communities	37
Number of Links involved in Communities	44

Path Summary
Number Of Nodes in MetaPath	99
Number Of Links MetaPath	98
Number of Shortest Paths	70749
Length Of Smallest Path	3
Average Path Length	16.3247
Length of Longest Path	41
Minimum Path Strength	1.38
Average Path Strength	6.7469
Maximum Path Strength	21.42
Minimum Path Correlation	0.7
Average Path Correlation	0.95082
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	54.9955
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	31.5001
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • regulation of cytokinesis • positive regulation of cell division • regulation of cell cycle process • positive regulation of biological process • cytokinesis • positive regulation of cell cycle • regulation of cell division • positive regulation of cytokinesis • positive regulation of cell cycle process • cell division • cell cycle • regulation of cell cycle • positive regulation of cellular process • cell cycle process • cell periphery • cellular anatomical structure • plasma membrane • membrane • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cell population proliferation • positive regulation of cell population proliferation • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • neural precursor cell proliferation • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of body fluid levels • multicellular organismal process • renal system process • system process • positive regulation of urine volume • regulation of urine volume • regulation of biological quality • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cell-cell signaling • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • cellular response to nitrogen compound • cellular response to acetylcholine • response to oxygen-containing compound • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • response to acetylcholine • response to nutrient levels • response to nutrient • midbody • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • cytosol • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • neuron to neuron synapse • synapse • cell junction • hippocampal mossy fiber to CA3 synapse • cell body • cilium • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • hormone activity • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9NSD7
Sequence	>9KFI_nogp_Chain_R E A R V R I L I S V V Y W V V C A L G L A G N L L V L Y L M K S M Q G W R K S S I N L F V T N L A L T D F Q F V L T L P F W A V E N A L D F K W P F G K A M C K I V S M V T S M N M Y A S V F F L T A M S V T R Y H S V A S A L K S H R T S C C F S A K A L C V W I W A L A A L A S L P S A I F S T T V K V M G E E L C L V R F P D K L L G R D R Q F W L G L Y H S Q K V L L G F V L P L G I I I L C Y L L L V R F I A D R R A G R P T G A S A R R L S K V T K S V T I V V L S F F L C W L P N Q A L T T W S I L I K F N A V P F S Q E Y F L C Q V Y A F P V S V C L A H S N S C L N P V L Y C L V R R E F R K A L K S L L W R I A S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9KFI	A	Peptide	Relaxin	RXFP3	Homo sapiens	Relaxin-3	-	Gi2/β1/γ2	2.91	2025-08-13	doi.org/10.1038/s42003-025-08220-7
	9KFI (No Gprot)	A	Peptide	Relaxin	RXFP3	Homo sapiens	Relaxin-3	-		2.91	2025-08-13	doi.org/10.1038/s42003-025-08220-7
	9KFJ	A	Peptide	Relaxin	RXFP3	Homo sapiens	PubChem 138319674	-	Gi2/β1/γ2	3.1	2025-08-13	doi.org/10.1038/s42003-025-08220-7
	9KFJ (No Gprot)	A	Peptide	Relaxin	RXFP3	Homo sapiens	PubChem 138319674	-		3.1	2025-08-13	doi.org/10.1038/s42003-025-08220-7

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