psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F17	3.53	Yes	No	0	0	5
2	L:L:?1	R:R:Q80	12.85	Yes	No	0	0	6
3	L:L:?1	R:R:H84	6.21	Yes	No	1	0	7
4	L:L:?1	R:R:L101	10.69	Yes	No	0	0	5
5	L:L:?1	R:R:F104	28.22	Yes	Yes	1	0	3
6	L:L:?1	R:R:I105	6.89	Yes	No	0	0	4
7	L:L:?1	R:R:V108	4.32	Yes	Yes	1	0	4
8	L:L:?1	R:R:R272	8.21	Yes	No	1	0	6
9	L:L:?1	R:R:Y278	11.32	Yes	Yes	1	0	7
10	R:R:F17	R:R:K89	19.85	No	No	0	5	2
11	R:R:D18	R:R:H84	5.04	No	No	0	7	7
12	R:R:L20	R:R:L27	9.69	No	No	0	2	5
13	R:R:L20	R:R:L85	16.61	No	Yes	0	2	5
14	R:R:L23	R:R:N21	5.49	No	No	0	3	3
15	R:R:L27	R:R:N21	6.87	No	No	0	5	3
16	R:R:L23	R:R:L26	6.92	No	No	0	3	3
17	R:R:T29	R:R:Y25	6.24	No	No	0	2	1
18	R:R:F31	R:R:L27	10.96	Yes	No	0	7	5
19	R:R:F28	R:R:L85	12.18	No	Yes	0	7	5
20	R:R:L33	R:R:T29	8.84	No	No	0	2	2
21	R:R:F31	R:R:I30	3.77	Yes	No	0	7	4
22	R:R:F31	R:R:M81	6.22	Yes	Yes	0	7	6
23	R:R:F32	R:R:M82	21.15	No	No	0	6	8
24	R:R:M284	R:R:T34	4.52	No	No	0	5	4
25	R:R:T38	R:R:Y35	8.74	Yes	Yes	1	7	9
26	R:R:Y35	R:R:Y73	4.96	Yes	Yes	1	9	4
27	R:R:V78	R:R:Y35	16.4	No	Yes	0	5	9
28	R:R:P283	R:R:Y35	12.52	Yes	Yes	1	9	9
29	R:R:T38	R:R:T74	7.85	Yes	No	0	7	7
30	R:R:P283	R:R:T38	5.25	Yes	Yes	1	9	7
31	R:R:M284	R:R:T38	7.53	No	Yes	0	5	7
32	R:R:D70	R:R:N42	13.46	No	No	0	9	9
33	R:R:I71	R:R:N42	4.25	No	No	0	6	9
34	R:R:N42	R:R:P287	6.52	No	No	0	9	9
35	R:R:I45	R:R:T291	12.16	No	Yes	0	7	8
36	R:R:D52	R:R:V48	4.38	No	Yes	0	6	5
37	R:R:I304	R:R:V48	4.61	No	Yes	0	4	5
38	R:R:T49	R:R:Y60	3.75	No	Yes	0	7	9
39	R:R:D52	R:R:L55	8.14	No	No	0	6	9
40	R:R:L55	R:R:Y60	8.21	No	Yes	0	9	9
41	R:R:T57	R:R:Y60	7.49	No	Yes	0	7	9
42	R:R:M136	R:R:P58	8.39	No	No	0	8	9
43	R:R:M59	R:R:Y60	5.99	No	Yes	0	9	9
44	R:R:D296	R:R:Y60	8.05	Yes	Yes	2	6	9
45	R:R:I297	R:R:Y60	7.25	No	Yes	2	8	9
46	R:R:K138	R:R:Y61	9.55	No	No	0	4	5
47	R:R:C141	R:R:Y61	4.03	No	No	0	7	5
48	R:R:F62	R:R:L114	4.87	Yes	Yes	0	7	6
49	R:R:F62	R:R:M118	8.71	Yes	No	0	7	9
50	R:R:D121	R:R:F62	3.58	No	Yes	0	9	7
51	R:R:C141	R:R:F62	4.19	No	Yes	0	7	7
52	R:R:F62	R:R:L144	7.31	Yes	No	0	7	7
53	R:R:L63	R:R:T291	8.84	No	Yes	0	8	8
54	R:R:L114	R:R:N65	9.61	Yes	No	0	6	7
55	R:R:A145	R:R:N65	4.69	No	No	0	6	7
56	R:R:E111	R:R:L66	7.95	Yes	No	0	8	9
57	R:R:L114	R:R:L66	11.07	Yes	No	0	6	9
58	R:R:L115	R:R:L66	4.15	No	No	0	8	9
59	R:R:I69	R:R:S110	4.64	No	No	0	5	5
60	R:R:I69	R:R:W149	5.87	No	No	0	5	5
61	R:R:D70	R:R:E111	3.9	No	Yes	0	9	8
62	R:R:D70	R:R:P283	8.05	No	Yes	0	9	9
63	R:R:C72	R:R:F107	5.59	No	No	0	4	4
64	R:R:N77	R:R:Y73	15.12	No	Yes	1	6	4
65	R:R:F104	R:R:Y73	10.32	Yes	Yes	1	3	4
66	R:R:F107	R:R:Y73	10.32	No	Yes	0	4	4
67	R:R:V108	R:R:Y73	5.05	Yes	Yes	1	4	4
68	R:R:S279	R:R:Y73	3.82	No	Yes	1	6	4
69	R:R:P283	R:R:Y73	6.95	Yes	Yes	1	9	4
70	R:R:F104	R:R:N77	9.67	Yes	No	1	3	6
71	R:R:M81	R:R:V78	6.09	Yes	No	0	6	5
72	R:R:M81	R:R:Q80	5.44	Yes	No	0	6	6
73	R:R:Q100	R:R:Q80	8.96	No	No	0	9	6
74	R:R:H84	R:R:R272	21.44	No	No	1	7	6
75	R:R:L85	R:R:L86	5.54	Yes	No	0	5	5
76	R:R:I91	R:R:K89	4.36	No	No	0	4	2
77	R:R:C97	R:R:I91	11.46	No	No	0	9	4
78	R:R:F164	R:R:V98	5.24	No	No	0	4	5
79	R:R:L101	R:R:Q100	3.99	No	No	0	5	9
80	R:R:F102	R:R:S156	3.96	Yes	No	0	5	5
81	R:R:F102	R:R:H159	11.31	Yes	No	0	5	4
82	R:R:F102	R:R:T160	6.49	Yes	Yes	3	5	5
83	R:R:F102	R:R:F164	6.43	Yes	No	3	5	4
84	R:R:F104	R:R:V108	7.87	Yes	Yes	1	3	4
85	R:R:F104	R:R:Y278	4.13	Yes	Yes	1	3	7
86	R:R:F104	R:R:S279	3.96	Yes	No	1	3	6
87	R:R:F106	R:R:F107	17.15	Yes	No	0	3	4
88	R:R:F106	R:R:S110	3.96	Yes	No	0	3	5
89	R:R:F106	R:R:W149	6.01	Yes	No	0	3	5
90	R:R:F106	R:R:G152	6.02	Yes	No	0	3	7
91	R:R:F106	R:R:F153	35.37	Yes	No	0	3	2
92	R:R:F106	R:R:S156	3.96	Yes	No	0	3	5
93	R:R:E111	R:R:T282	8.47	Yes	Yes	1	8	8
94	R:R:E111	R:R:N286	10.52	Yes	No	1	8	9
95	R:R:C112	R:R:P210	3.77	No	No	0	5	7
96	R:R:C148	R:R:L114	11.11	No	Yes	0	5	6
97	R:R:L115	R:R:N286	9.61	No	No	0	8	9
98	R:R:L115	R:R:Y290	8.21	No	Yes	0	8	9
99	R:R:M118	R:R:Y290	5.99	No	Yes	0	9	9
100	R:R:A119	R:R:Y218	5.34	No	No	0	9	9
101	R:R:Y120	R:R:Y123	9.93	No	Yes	4	6	7
102	R:R:S217	R:R:Y120	7.63	No	No	4	9	6
103	R:R:D121	R:R:M136	4.16	No	No	0	9	8
104	R:R:I124	R:R:Y123	4.84	No	Yes	0	7	7
105	R:R:C127	R:R:Y123	4.03	No	Yes	0	8	7
106	R:R:S217	R:R:Y123	6.36	No	Yes	4	9	7
107	R:R:I221	R:R:Y123	7.25	No	Yes	0	9	7
108	R:R:A125	R:R:Y132	6.67	No	No	0	9	9
109	R:R:K128	R:R:R131	12.38	No	No	0	4	6
110	R:R:I135	R:R:R131	10.02	No	No	0	6	6
111	R:R:M136	R:R:Y132	10.78	No	No	0	8	9
112	R:R:F134	R:R:I135	6.28	No	No	0	5	6
113	R:R:A139	R:R:N137	4.69	No	No	0	3	7
114	R:R:L140	R:R:N137	4.12	No	No	0	3	7
115	R:R:H159	R:R:T163	9.58	No	No	0	4	5
116	R:R:H159	R:R:L199	9	No	No	0	4	4
117	R:R:F164	R:R:T160	6.49	No	Yes	3	4	5
118	R:R:N195	R:R:T163	5.85	No	No	0	5	5
119	R:R:E196	R:R:L199	5.3	No	No	0	5	4
120	R:R:G207	R:R:Y252	4.35	No	No	0	3	6
121	R:R:P210	R:R:T209	5.25	No	No	0	7	1
122	R:R:F211	R:R:I215	7.54	No	No	0	4	3
123	R:R:F211	R:R:V248	6.55	No	No	0	4	8
124	R:R:F211	R:R:I249	8.79	No	No	0	4	5
125	R:R:H244	R:R:V214	8.3	Yes	No	0	9	8
126	R:R:I215	R:R:L245	11.42	No	No	0	3	7
127	R:R:C241	R:R:Y218	6.72	No	No	0	9	9
128	R:R:H244	R:R:Y218	40.29	Yes	No	0	9	9
129	R:R:F238	R:R:I222	3.77	No	No	0	7	6
130	R:R:H244	R:R:L245	6.43	Yes	No	0	9	7
131	R:R:H244	R:R:Y290	7.62	Yes	Yes	0	9	9
132	R:R:I249	R:R:L246	8.56	No	No	0	5	5
133	R:R:I247	R:R:L285	5.71	No	No	0	8	7
134	R:R:I247	R:R:I289	5.89	No	No	5	8	9
135	R:R:Y251	R:R:Y252	11.91	No	No	0	5	6
136	R:R:Y251	R:R:Y278	25.81	No	Yes	0	5	7
137	R:R:V281	R:R:Y251	7.57	No	No	0	5	5
138	R:R:I256	R:R:Y252	10.88	No	No	0	5	6
139	R:R:A255	R:R:Y259	5.34	No	Yes	1	4	7
140	R:R:A255	R:R:Y278	5.34	No	Yes	1	4	7
141	R:R:F257	R:R:T258	6.49	No	Yes	0	4	5
142	R:R:F257	R:R:R261	18.17	No	Yes	0	4	5
143	R:R:T258	R:R:Y259	3.75	Yes	Yes	1	5	7
144	R:R:K270	R:R:T258	4.5	No	Yes	0	3	5
145	R:R:I274	R:R:T258	15.2	No	Yes	1	4	5
146	R:R:I274	R:R:Y259	8.46	No	Yes	1	4	7
147	R:R:Y259	R:R:Y278	3.97	Yes	Yes	1	7	7
148	R:R:R261	R:R:V260	6.54	Yes	No	0	5	4
149	R:R:R261	R:R:S264	11.86	Yes	No	0	5	5
150	R:R:S265	R:R:S267	4.89	No	No	0	4	6
151	R:R:K270	R:R:S267	4.59	No	No	0	3	6
152	R:R:D271	R:R:K270	4.15	No	No	0	6	3
153	R:R:T282	R:R:V281	4.76	Yes	No	0	8	5
154	R:R:L285	R:R:V281	5.96	No	No	0	7	5
155	R:R:P283	R:R:T282	5.25	Yes	Yes	1	9	8
156	R:R:N286	R:R:T282	7.31	No	Yes	1	9	8
157	R:R:I289	R:R:Y290	6.04	No	Yes	0	9	9
158	R:R:L292	R:R:T291	4.42	No	Yes	0	8	8
159	R:R:I297	R:R:T291	6.08	No	Yes	0	8	8
160	R:R:D296	R:R:I297	4.2	Yes	No	2	6	8
161	R:R:P58	R:R:T57	3.5	No	No	0	9	7
162	R:R:G40	R:R:L39	3.42	No	No	0	3	5
163	R:R:C241	R:R:I222	3.27	No	No	0	9	6
164	R:R:A67	R:R:I45	3.25	No	No	0	8	7
165	R:R:S87	R:R:V83	3.23	No	No	0	4	3
166	R:R:T160	R:R:V157	3.17	Yes	No	0	5	2
167	R:R:T160	R:R:V161	3.17	Yes	No	0	5	3
168	R:R:I92	R:R:S93	3.1	No	No	0	9	8
169	R:R:M82	R:R:V83	3.04	No	No	0	8	3
170	R:R:F44	R:R:G41	3.01	No	No	0	4	7
171	R:R:L277	R:R:S254	3	No	No	0	5	7
172	R:R:L39	R:R:V43	2.98	No	No	0	5	1
173	R:R:Y123	R:R:Y220	2.98	Yes	No	0	7	1
174	R:R:I46	R:R:I50	2.94	Yes	No	0	7	1
175	R:R:I46	R:R:I71	2.94	Yes	No	0	7	6
176	R:R:I126	R:R:I221	2.94	No	No	0	9	9
177	R:R:I222	R:R:I225	2.94	No	No	0	6	8
178	R:R:N77	R:R:T76	2.92	No	No	0	6	5
179	L:L:?1	R:R:S275	2.9	Yes	No	0	0	7
180	R:R:E232	R:R:S231	2.87	No	No	0	4	4
181	R:R:I204	R:R:L200	2.85	No	No	0	4	4
182	R:R:I202	R:R:L205	2.85	No	No	0	4	1
183	R:R:I105	R:R:N155	2.83	No	No	0	4	4
184	R:R:I202	R:R:N155	2.83	No	No	0	4	4
185	R:R:A117	R:R:F62	2.77	No	Yes	0	6	7
186	R:R:L158	R:R:L162	2.77	No	No	0	4	4
187	R:R:D296	R:R:K295	2.77	Yes	No	0	6	6
188	R:R:C213	R:R:Y120	2.69	No	No	0	4	6
189	R:R:A146	R:R:W143	2.59	No	No	0	4	1
190	R:R:R293	R:R:T240	2.59	No	No	0	9	9
191	R:R:H54	R:R:L55	2.57	No	No	0	4	9
192	R:R:I91	R:R:Y94	2.42	No	No	0	4	4
193	R:R:I263	R:R:Y266	2.42	No	No	0	5	3
194	R:R:F28	R:R:F32	2.14	No	No	0	7	6
195	R:R:F31	R:R:F32	2.14	Yes	No	0	7	6
196	R:R:G40	R:R:G41	2.11	No	No	0	3	7
197	R:R:G95	R:R:G96	2.11	No	No	0	1	4
198	R:R:G151	R:R:G152	2.11	No	No	0	4	7
199	R:R:A67	R:R:G64	1.95	No	No	0	8	4
200	R:R:G109	R:R:V108	1.84	No	Yes	0	3	4
201	R:R:G96	R:R:T99	1.82	No	No	0	4	4
202	R:R:G151	R:R:T150	1.82	No	No	0	4	3
203	R:R:P79	R:R:V78	1.77	No	No	0	9	5
204	R:R:G95	R:R:I92	1.76	No	No	0	1	9
205	R:R:G203	R:R:I202	1.76	No	No	0	5	4
206	R:R:G305	R:R:I304	1.76	No	No	0	1	4
207	R:R:G305	R:R:K302	1.74	No	No	0	1	4
208	R:R:G151	R:R:L113	1.71	No	No	0	4	3
209	R:R:A198	R:R:S201	1.71	No	No	0	4	3
210	R:R:A300	R:R:V48	1.7	No	Yes	0	7	5
211	R:R:A116	R:R:V214	1.7	No	No	0	7	8
212	R:R:C213	R:R:T209	1.69	No	No	0	4	1
213	R:R:A103	R:R:T76	1.68	No	No	0	4	5
214	R:R:K90	R:R:P79	1.67	No	No	0	4	9
215	R:R:K128	R:R:P129	1.67	No	No	0	4	9
216	R:R:C37	R:R:I36	1.64	No	No	0	4	4
217	R:R:G96	R:R:Q100	1.64	No	No	0	4	9
218	R:R:L113	R:R:P210	1.64	No	No	0	3	7
219	R:R:C241	R:R:I221	1.64	No	No	0	9	9
220	R:R:A237	R:R:I225	1.62	No	No	0	8	8
221	R:R:V43	R:R:V47	1.6	No	No	0	1	3
222	R:R:V301	R:R:V48	1.6	No	Yes	0	5	5
223	R:R:V276	R:R:V280	1.6	No	No	0	6	5
224	R:R:G233	R:R:H235	1.59	No	No	0	7	2
225	R:R:I228	R:R:S230	1.55	No	No	0	6	8
226	R:R:I247	R:R:S243	1.55	No	No	5	8	8
227	R:R:I289	R:R:S243	1.55	No	No	5	9	8
228	R:R:I46	R:R:V47	1.54	Yes	No	0	7	3
229	R:R:I304	R:R:V47	1.54	No	No	0	4	3
230	R:R:M81	R:R:V276	1.52	Yes	No	0	6	6
231	R:R:M284	R:R:V288	1.52	No	No	0	5	5
232	R:R:L144	R:R:S147	1.5	No	No	0	7	3
233	R:R:L39	R:R:T75	1.47	No	No	0	5	7
234	R:R:I225	R:R:I228	1.47	No	No	0	8	6
235	R:R:E88	R:R:S87	1.44	No	No	0	3	4
236	R:R:P262	R:R:R261	1.44	No	Yes	0	8	5
237	R:R:I46	R:R:L68	1.43	Yes	No	0	7	4
238	R:R:I69	R:R:L68	1.43	No	No	0	5	4
239	R:R:I249	R:R:L250	1.43	No	No	0	5	5
240	R:R:L154	R:R:L158	1.38	No	No	0	3	4
241	R:R:L250	R:R:L277	1.38	No	No	0	5	5
242	R:R:D18	R:R:L268	1.36	No	No	0	7	3
243	R:R:D296	R:R:N294	1.35	Yes	No	0	6	9
244	R:R:E22	R:R:L23	1.33	No	No	0	3	3
245	R:R:L85	R:R:Q24	1.33	Yes	No	0	5	6
246	R:R:H19	R:R:L86	1.29	No	No	0	4	5
247	R:R:I228	R:R:R227	1.25	No	No	0	6	5
248	R:R:N294	R:R:R122	1.21	No	No	0	9	9
249	R:R:L226	R:R:R229	1.21	No	No	0	6	4
250	R:R:L273	R:R:R272	1.21	No	No	0	5	6
251	R:R:E232	R:R:R234	1.16	No	No	0	4	7
252	R:R:L212	R:R:W208	1.14	No	No	0	1	3
253	R:R:F238	R:R:H235	1.13	No	No	0	7	2
254	R:R:F238	R:R:R234	1.07	No	No	0	7	7
255	R:R:F28	R:R:Y25	1.03	No	No	0	7	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.514	10	1	0
2	R:R:F31	5.7725	4	0	7
3	R:R:Y35	10.655	4	1	9
4	R:R:T38	7.3425	4	1	7
5	R:R:I46	2.2125	4	0	7
6	R:R:V48	3.0725	4	0	5
7	R:R:Y60	6.79	6	2	9
8	R:R:F62	5.23833	6	0	7
9	R:R:Y73	8.07714	7	1	4
10	R:R:M81	4.8175	4	0	6
11	R:R:L85	8.915	4	0	5
12	R:R:F102	7.0475	4	3	5
13	R:R:F104	10.695	6	1	3
14	R:R:F106	12.0783	6	0	3
15	R:R:V108	4.77	4	1	4
16	R:R:E111	7.71	4	1	8
17	R:R:L114	9.165	4	0	6
18	R:R:Y123	5.89833	6	4	7
19	R:R:T160	4.83	4	3	5
20	R:R:H244	15.66	4	0	9
21	R:R:T258	7.485	4	1	5
22	R:R:Y259	5.38	4	1	7
23	R:R:R261	9.5025	4	0	5
24	R:R:Y278	10.114	5	1	7
25	R:R:T282	6.4475	4	1	8
26	R:R:P283	7.604	5	1	9
27	R:R:Y290	6.965	4	0	9
28	R:R:T291	7.875	4	0	8
29	R:R:D296	4.0925	4	2	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F17	22.4174	3.53	Yes	No	0	0	5
2	R:R:F17	R:R:K89	18.3332	19.85	No	No	0	5	2
3	L:L:?1	R:R:H84	12.9898	6.21	Yes	No	1	0	7
4	L:L:?1	R:R:Q80	40.2949	12.85	Yes	No	0	0	6
5	R:R:M81	R:R:Q80	22.3511	5.44	Yes	No	0	6	6
6	R:R:F31	R:R:M81	52.5971	6.22	Yes	Yes	0	7	6
7	R:R:F31	R:R:L27	21.6138	10.96	Yes	No	0	7	5
8	R:R:L20	R:R:L27	11.0099	9.69	No	No	0	2	5
9	R:R:F31	R:R:F32	27.9761	2.14	Yes	No	0	7	6
10	R:R:F28	R:R:F32	17.4965	2.14	No	No	0	7	6
11	L:L:?1	R:R:F104	47.9828	28.22	Yes	Yes	1	0	3
12	R:R:F104	R:R:Y73	56.3665	10.32	Yes	Yes	1	3	4
13	R:R:Y35	R:R:Y73	14.3153	4.96	Yes	Yes	1	9	4
14	L:L:?1	R:R:V108	46.7401	4.32	Yes	Yes	1	0	4
15	R:R:V108	R:R:Y73	48.8278	5.05	Yes	Yes	1	4	4
16	R:R:P283	R:R:Y73	100	6.95	Yes	Yes	1	9	4
17	R:R:M81	R:R:V78	54.5274	6.09	Yes	No	0	6	5
18	R:R:D70	R:R:P283	72.7943	8.05	No	Yes	0	9	9
19	R:R:D70	R:R:N42	54.3534	13.46	No	No	0	9	9
20	R:R:I71	R:R:N42	50.4598	4.25	No	No	0	6	9
21	R:R:I46	R:R:I71	49.0432	2.94	Yes	No	0	7	6
22	R:R:I46	R:R:V47	57.4766	1.54	Yes	No	0	7	3
23	R:R:I304	R:R:V47	41.2393	1.54	No	No	0	4	3
24	R:R:I304	R:R:V48	34.6864	4.61	No	Yes	0	4	5
25	R:R:D52	R:R:V48	28.7963	4.38	No	Yes	0	6	5
26	R:R:D52	R:R:L55	27.5951	8.14	No	No	0	6	9
27	R:R:L55	R:R:Y60	25.4577	8.21	No	Yes	0	9	9
28	R:R:I297	R:R:Y60	30.6685	7.25	No	Yes	2	8	9
29	R:R:I297	R:R:T291	27.0317	6.08	No	Yes	0	8	8
30	R:R:I45	R:R:T291	13.5863	12.16	No	Yes	0	7	8
31	R:R:D70	R:R:E111	51.5947	3.9	No	Yes	0	9	8
32	R:R:E111	R:R:L66	88.841	7.95	Yes	No	0	8	9
33	R:R:L114	R:R:L66	81.2692	11.07	Yes	No	0	6	9
34	R:R:F62	R:R:L114	70.599	4.87	Yes	Yes	0	7	6
35	R:R:D121	R:R:F62	60.3098	3.58	No	Yes	0	9	7
36	R:R:D121	R:R:M136	57.8245	4.16	No	No	0	9	8
37	R:R:M136	R:R:P58	48.7946	8.39	No	No	0	8	9
38	R:R:P58	R:R:T57	45.8786	3.5	No	No	0	9	7
39	R:R:T57	R:R:Y60	43.5838	7.49	No	Yes	0	7	9
40	R:R:P283	R:R:T282	80.623	5.25	Yes	Yes	1	9	8
41	R:R:E111	R:R:T282	49.3	8.47	Yes	Yes	1	8	8
42	L:L:?1	R:R:Y278	37.3871	11.32	Yes	Yes	1	0	7
43	R:R:Y251	R:R:Y278	45.1744	25.81	No	Yes	0	5	7
44	R:R:V281	R:R:Y251	46.9307	7.57	No	No	0	5	5
45	R:R:T282	R:R:V281	34.8687	4.76	Yes	No	0	8	5
46	R:R:C141	R:R:F62	10.0737	4.19	No	Yes	0	7	7
47	R:R:N286	R:R:T282	55.7452	7.31	No	Yes	1	9	8
48	R:R:L115	R:R:N286	61.859	9.61	No	No	0	8	9
49	R:R:L115	R:R:Y290	68.677	8.21	No	Yes	0	8	9
50	R:R:M118	R:R:Y290	15.6574	5.99	No	Yes	0	9	9
51	R:R:F107	R:R:Y73	50.3189	10.32	No	Yes	0	4	4
52	R:R:F106	R:R:F107	48.4467	17.15	Yes	No	0	3	4
53	R:R:F106	R:R:S110	12.3685	3.96	Yes	No	0	3	5
54	R:R:I69	R:R:S110	10.6288	4.64	No	No	0	5	5
55	R:R:F106	R:R:W149	12.3685	6.01	Yes	No	0	3	5
56	R:R:I69	R:R:W149	10.6288	5.87	No	No	0	5	5
57	L:L:?1	R:R:L101	29.5336	10.69	Yes	No	0	0	5
58	R:R:L101	R:R:Q100	25.6068	3.99	No	No	0	5	9
59	R:R:I91	R:R:K89	13.6194	4.36	No	No	0	4	2
60	R:R:F106	R:R:S156	30.2626	3.96	Yes	No	0	3	5
61	R:R:F102	R:R:S156	27.7442	3.96	Yes	No	0	5	5
62	R:R:F102	R:R:H159	12.5839	11.31	Yes	No	0	5	4
63	R:R:F106	R:R:G152	25.7477	6.02	Yes	No	0	3	7
64	R:R:G151	R:R:G152	23.6352	2.11	No	No	0	4	7
65	R:R:G151	R:R:L113	19.5924	1.71	No	No	0	4	3
66	R:R:L113	R:R:P210	17.6705	1.64	No	No	0	3	7
67	R:R:L285	R:R:V281	20.2303	5.96	No	No	0	7	5
68	R:R:I247	R:R:L285	19.0871	5.71	No	No	0	8	7
69	R:R:I247	R:R:I289	16.403	5.89	No	No	5	8	9
70	R:R:I289	R:R:Y290	17.7284	6.04	No	Yes	0	9	9
71	R:R:H244	R:R:Y290	89.1641	7.62	Yes	Yes	0	9	9
72	R:R:H244	R:R:Y218	59.5891	40.29	Yes	No	0	9	9
73	R:R:P210	R:R:T209	14.5224	5.25	No	No	0	7	1
74	R:R:C213	R:R:T209	13.2466	1.69	No	No	0	4	1
75	R:R:C213	R:R:Y120	12.2774	2.69	No	No	0	4	6
76	R:R:Y120	R:R:Y123	10.1234	9.93	No	Yes	4	6	7
77	R:R:C241	R:R:Y218	54.9167	6.72	No	No	0	9	9
78	R:R:C241	R:R:I221	22.4422	1.64	No	No	0	9	9
79	R:R:I221	R:R:Y123	17.9273	7.25	No	Yes	0	9	7
80	R:R:H244	R:R:L245	27.2803	6.43	Yes	No	0	9	7
81	R:R:I215	R:R:L245	24.3145	11.42	No	No	0	3	7
82	R:R:F211	R:R:I215	21.3321	7.54	No	No	0	4	3
83	R:R:F211	R:R:I249	15.3177	8.79	No	No	0	4	5
84	R:R:C241	R:R:I222	36.5173	3.27	No	No	0	9	6
85	R:R:Y259	R:R:Y278	24.8778	3.97	Yes	Yes	1	7	7
86	R:R:T258	R:R:Y259	21.3238	3.75	Yes	Yes	1	5	7
87	R:R:F257	R:R:T258	11.0513	6.49	No	Yes	0	4	5
88	R:R:V43	R:R:V47	16.842	1.6	No	No	0	1	3
89	R:R:L39	R:R:V43	14.0751	2.98	No	No	0	5	1
90	R:R:Q100	R:R:Q80	33.7503	8.96	No	No	0	9	6
91	R:R:G96	R:R:Q100	49.6562	1.64	No	No	0	4	9
92	R:R:G95	R:R:G96	29.8401	2.11	No	No	0	1	4
93	R:R:G95	R:R:I92	19.9072	1.76	No	No	0	1	9
94	R:R:I222	R:R:I225	15.4005	2.94	No	No	0	6	8
95	R:R:F238	R:R:I222	18.5486	3.77	No	No	0	7	6
96	L:L:?1	R:R:I105	22.7902	6.89	Yes	No	0	0	4
97	R:R:I105	R:R:N155	18.3332	2.83	No	No	0	4	4
98	R:R:I202	R:R:N155	13.6194	2.83	No	No	0	4	4
99	R:R:D296	R:R:Y60	16.7343	8.05	Yes	Yes	2	6	9
100	R:R:I69	R:R:L68	18.706	1.43	No	No	0	5	4
101	R:R:V78	R:R:Y35	57.9405	16.4	No	Yes	0	5	9
102	R:R:P283	R:R:Y35	47.378	12.52	Yes	Yes	1	9	9
103	R:R:F104	R:R:Y278	10.4465	4.13	Yes	Yes	1	3	7
104	R:R:I46	R:R:L68	17.687	1.43	Yes	No	0	7	4
105	R:R:F62	R:R:M118	13.6526	8.71	Yes	No	0	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F17	3.53	1	Yes	No	0	5	0	1
L:L:?1	R:R:Q80	12.85	1	Yes	No	0	6	0	1
L:L:?1	R:R:H84	6.21	1	Yes	No	0	7	0	1
L:L:?1	R:R:L101	10.69	1	Yes	No	0	5	0	1
L:L:?1	R:R:F104	28.22	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:I105	6.89	1	Yes	No	0	4	0	1
L:L:?1	R:R:V108	4.32	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:R272	8.21	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y278	11.32	1	Yes	Yes	0	7	0	1
R:R:F17	R:R:K89	19.85	0	No	No	5	2	1	2
R:R:D18	R:R:H84	5.04	0	No	No	7	7	2	1
R:R:N77	R:R:Y73	15.12	1	No	Yes	6	4	2	2
R:R:F104	R:R:Y73	10.32	1	Yes	Yes	3	4	1	2
R:R:V108	R:R:Y73	5.05	1	Yes	Yes	4	4	1	2
R:R:S279	R:R:Y73	3.82	1	No	Yes	6	4	2	2
R:R:F104	R:R:N77	9.67	1	Yes	No	3	6	1	2
R:R:M81	R:R:Q80	5.44	0	Yes	No	6	6	2	1
R:R:Q100	R:R:Q80	8.96	0	No	No	9	6	2	1
R:R:H84	R:R:R272	21.44	1	No	No	7	6	1	1
R:R:L101	R:R:Q100	3.99	0	No	No	5	9	1	2
R:R:F104	R:R:V108	7.87	1	Yes	Yes	3	4	1	1
R:R:F104	R:R:Y278	4.13	1	Yes	Yes	3	7	1	1
R:R:F104	R:R:S279	3.96	1	Yes	No	3	6	1	2
R:R:Y251	R:R:Y278	25.81	0	No	Yes	5	7	2	1
R:R:A255	R:R:Y259	5.34	1	No	Yes	4	7	2	2
R:R:A255	R:R:Y278	5.34	1	No	Yes	4	7	2	1
R:R:Y259	R:R:Y278	3.97	1	Yes	Yes	7	7	2	1
L:L:?1	R:R:S275	2.9	1	Yes	No	0	7	0	1
R:R:I105	R:R:N155	2.83	0	No	No	4	4	1	2
R:R:G109	R:R:V108	1.84	0	No	Yes	3	4	2	1
R:R:L273	R:R:R272	1.21	0	No	No	5	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9LKB_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.53
Number of Linked Nodes	240
Number of Links	255
Number of Hubs	29
Number of Links mediated by Hubs	116
Number of Communities	5
Number of Nodes involved in Communities	31
Number of Links involved in Communities	41

Path Summary
Number Of Nodes in MetaPath	106
Number Of Links MetaPath	105
Number of Shortest Paths	42048
Length Of Smallest Path	3
Average Path Length	12.8638
Length of Longest Path	25
Minimum Path Strength	1.1
Average Path Strength	7.50535
Maximum Path Strength	26.26
Minimum Path Correlation	0.7
Average Path Correlation	0.918478
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	43.7639
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.3093
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • multicellular organismal process • system process • nervous system process • sensory perception of smell • detection of stimulus • sensory perception of chemical stimulus • sensory perception • response to chemical • detection of chemical stimulus • detection of chemical stimulus involved in sensory perception of smell • detection of stimulus involved in sensory perception • detection of chemical stimulus involved in sensory perception • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	A2RT31
Sequence	>9LKB_nogp_Chain_R F D H L N E L Q Y L L F T I F F L T Y I C T L G G N V F I I V V T I A D S H L H T P M Y Y F L G N L A L I D I C Y T T T N V P Q M M V H L L S E K K I I S Y G G C V T Q L F A F I F F V G S E C L L L A A M A Y D R Y I A I C K P L R Y S F I M N K A L C S W L A A S C W T G G F L N S V L H T V L T F N E L A L L S I G I L I G W T P F L C V I L S Y L Y I I S T I L R I R S S E G R H K A F S T C A S H L L I V I L Y Y G S A I F T Y V R P I S S Y S L E K D R L I S V L Y S V V T P M L N P V I Y T L R N K D I K E A V K A I G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9LKD	O2	Odorant	Odorant family 5	OR5V1	Mus musculus	PL45	-	-	3.6	2026-01-21	To be published
	9LKB	O2	Odorant	Odorant family 5	OR5V1	Mus musculus	PL45	-	chim(NtGi1-Gs)/β1	3.7	2026-01-21	To be published
	9LKB (No Gprot)	O2	Odorant	Odorant family 5	OR5V1	Mus musculus	PL45	-		3.7	2026-01-21	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9LKB_nogp.zip

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