Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:T407 4.87254189
2R:R:H408 7.275409
3R:R:F409 5.21754169
4R:R:L412 5.665409
5R:R:D423 4.54254194
6R:R:Y424 3.735403
7R:R:I430 2.89408
8R:R:F452 7.84407
9R:R:E454 5.20254215
10R:R:I455 4.5625407
11R:R:H463 6.9875408
12R:R:F471 3.3925406
13R:R:H498 4.70667669
14R:R:Y499 3.32406
15R:R:W507 10.7654179
16R:R:M508 2.855409
17R:R:Y538 5.375179
18R:R:P541 2.8725409
19R:R:Y555 9.21333665
20R:R:Y556 4.79769
21R:R:W563 7.03409
22R:R:L564 5.5575469
23R:R:F570 6.5468
24R:R:I571 3.3825407
25R:R:I575 4.94407
26R:R:N585 2.585409
27R:R:F589 3.1575407
28R:R:N612 5.1525405
29R:R:W631 6.508336169
30R:R:F649 4.9745169
31R:R:N653 7.34169
32R:R:F655 3.408508
33R:R:F661 6.8554209
34R:R:F663 3.52754247
35A:A:Q19 8.725444
36A:A:L44 5.2875429
37A:A:K53 5.4539
38A:A:I56 3.3725437
39A:A:R61 3.42598
40A:A:H64 5.5375408
41A:A:F219 5.9885148
42A:A:M221 4.218598
43A:A:F222 9.505427
44A:A:D223 4.6225439
45A:A:R231 4.764259
46A:A:R232 11.1325418
47A:A:K233 7.865419
48A:A:W234 10.99254259
49A:A:F238 6.5425429
50A:A:I244 4.315428
51A:A:V247 3.8825437
52A:A:Y253 7.6825408
53A:A:R265 7.906509
54A:A:F273 4.92409
55A:A:W277 6.606506
56A:A:W281 9.3975405
57A:A:F290 4.6325409
58A:A:N292 4.378539
59A:A:K293 6.3275439
60A:A:Q294 4.88476
61A:A:L296 3.52436
62A:A:F312 3.15254268
63A:A:E314 2.6354266
64A:A:P321 4.55405
65A:A:E330 4.438573
66A:A:V334 2.796574
67A:A:K338 6.625475
68A:A:F340 8.9365267
69A:A:R342 6.396504
70A:A:F345 6.06408
71A:A:L346 4.874234
72A:A:S349 4.39754237
73A:A:Y358 6.8254134
74A:A:T364 5.59439
75A:A:F376 4.876148
76A:A:Q385 5.0365135
77B:B:I37 3.8775402
78B:B:H54 6.75333649
79B:B:K57 7.652529
80B:B:Y59 8.2325428
81B:B:M61 3.894116
82B:B:W63 4.9165117
83B:B:D76 7.0625409
84B:B:W82 7.72571749
85B:B:D83 8.0625448
86B:B:K89 4.64429749
87B:B:L95 3.945408
88B:B:W99 7.80167629
89B:B:Y105 3.8925406
90B:B:Y111 6.015404
91B:B:Y124 4.766506
92B:B:E138 4.5075406
93B:B:L139 4.6125409
94B:B:H142 6.1065159
95B:B:Y145 3.655418
96B:B:F151 2.5275409
97B:B:T159 5.35754159
98B:B:D163 8.5175409
99B:B:W169 8.4185158
100B:B:Q176 7.894154
101B:B:F180 7.178557
102B:B:H183 7.276559
103B:B:D186 5.362519
104B:B:D205 5.7325459
105B:B:K209 8.062556
106B:B:W211 7.372558
107B:B:D212 9.374309
108B:B:F222 9.83418
109B:B:H225 6.65619
110B:B:D228 7.296519
111B:B:I232 4.3175408
112B:B:F235 5.976126
113B:B:N237 8.30254125
114B:B:F241 6.576516
115B:B:T243 5.5575418
116B:B:D247 4.555419
117B:B:R251 10.9575418
118B:B:F253 8.7375416
119B:B:Y264 4.506676285
120B:B:C271 2.455405
121B:B:F278 4.29407
122B:B:R283 6.098509
123B:B:Y289 5.405607
124B:B:N295 5.68254316
125B:B:V296 3.9405
126B:B:K301 5.8405
127B:B:H311 6.785689
128B:B:R314 10.052528
129B:B:T321 5.474117
130B:B:W332 10.23629
131B:B:D333 6.4325489
132B:B:F335 6.18404
133B:B:K337 6.47586
134B:B:W339 7.004589
135G:G:K29 2.8745274
136G:G:K32 1.865405
137G:G:L37 3.365127
138G:G:D48 5.256509
139G:G:L51 3.4225406
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:I411 R:R:T407 34.1583.04NoYes079
2R:R:I481 R:R:T407 41.33233.04NoYes1879
3R:R:H408 R:R:I411 33.263811.93YesNo097
4R:R:H408 R:R:L427 20.72457.71YesNo099
5R:R:F409 R:R:L412 30.06287.31YesYes099
6R:R:F477 R:R:L412 29.42084.87NoYes099
7R:R:F477 R:R:I481 43.12323.77NoNo097
8R:R:F409 R:R:W631 14.47913.01YesYes1699
9R:R:F501 R:R:L412 29.48193.65NoYes089
10R:R:L412 R:R:W563 29.85566.83YesYes099
11R:R:F477 R:R:L497 14.71573.65NoNo098
12R:R:L497 R:R:W563 17.34354.56NoYes089
13R:R:L427 R:R:T650 13.51864.42NoNo098
14R:R:I430 R:R:T650 12.61863.04YesNo088
15R:R:F655 R:R:I430 10.82952.51YesYes088
16R:R:F452 R:R:I455 94.3513.77YesYes077
17R:R:I455 R:R:T460 93.77936.08YesNo077
18R:R:F449 R:R:T460 93.39813.89NoNo097
19R:R:F449 R:R:H463 92.82644.53NoYes098
20R:R:E511 R:R:H463 86.07188.62NoYes098
21R:R:E511 R:R:I462 85.77145.47NoNo098
22R:R:I462 R:R:T458 85.24253.04NoNo2287
23R:R:H530 R:R:T458 95.7179.58NoNo057
24R:R:H530 R:R:L529 94.97143.86NoNo056
25R:R:F533 R:R:L529 94.72243.65NoNo076
26R:R:F533 R:R:I510 94.473110.05NoNo077
27R:R:I510 R:R:W507 93.97388.22NoYes079
28R:R:W507 R:R:Y538 92.348912.54YesYes1799
29R:R:Y499 R:R:Y538 91.13012.98YesYes069
30R:R:P541 R:R:Y499 89.61072.78YesYes096
31R:R:L502 R:R:P541 88.84773.28NoYes099
32R:R:H498 R:R:L502 88.33773.86YesNo099
33R:R:F574 R:R:H498 77.13235.66NoYes099
34R:R:F501 R:R:F574 30.04854.29NoNo089
35R:R:F574 R:R:W563 46.831812.03NoYes099
36R:R:E674 R:R:F452 97.83414.66NoYes087
37R:R:E454 R:R:E674 97.968.88YesNo2158
38B:B:F335 R:R:E454 98.66257YesYes045
39R:R:H514 R:R:T458 10.72245.48NoNo2267
40R:R:H514 R:R:I518 10.802110.61NoNo068
41A:A:N387 R:R:I518 12.37334.25NoNo088
42A:A:D381 R:R:H599 22.56137.56NoNo087
43A:A:D381 A:A:Y360 22.38369.2NoNo088
44A:A:I382 A:A:Y360 13.20074.84NoNo068
45A:A:I382 A:A:M386 12.85691.46NoNo063
46A:A:I383 A:A:M386 12.68721.46NoNo083
47A:A:I383 A:A:N387 12.52074.25NoNo088
48A:A:Q385 R:R:H599 22.30156.18YesNo057
49A:A:Q385 A:A:Y358 25.15783.38YesYes1354
50A:A:Y358 R:R:P605 25.75946.95YesNo045
51R:R:K604 R:R:P605 10.1443.35NoNo065
52A:A:L346 R:R:K604 10.17064.23YesNo046
53A:A:T350 R:R:P605 15.79713.5NoNo045
54A:A:N23 B:B:N88 13.416614.98NoNo477
55A:A:N23 B:B:K89 13.76955.6NoYes479
56B:B:K89 B:B:W82 15.79848.12YesYes499
57B:B:L70 B:B:W82 20.94995.69NoYes059
58B:B:L70 B:B:M61 21.29592.83NoYes056
59B:B:M61 B:B:W63 10.36224.65YesYes1167
60B:B:T321 B:B:W63 10.312110.92YesYes1177
61B:B:D323 B:B:T321 10.05174.34NoYes1177
62B:B:D323 B:B:M325 10.10764.16NoNo075
63B:B:M325 G:G:P49 10.05843.35NoNo057
64G:G:D48 G:G:P49 10.08954.83YesNo097
65B:B:S279 G:G:D48 14.0422.94NoYes099
66B:B:L284 B:B:S279 14.27094.5NoNo059
67B:B:L284 B:B:V296 15.42715.96NoYes055
68B:B:L308 B:B:V296 1002.98NoYes075
69B:B:L308 B:B:W339 99.97387.97NoYes079
70B:B:H311 B:B:W339 49.90393.17YesYes899
71B:B:D333 B:B:H311 49.67046.3YesYes899
72B:B:D333 B:B:F335 49.5789.55YesYes094
73B:B:C317 B:B:M61 19.0714.86NoYes076
74B:B:C317 B:B:S316 19.54323.44NoNo079
75B:B:S316 B:B:W332 19.78234.94NoYes099
76B:B:R314 B:B:W332 96.759221.99YesYes289
77B:B:R314 B:B:T274 86.61285.17YesNo288
78B:B:S275 B:B:T274 93.47173.2NoNo088
79B:B:L318 B:B:S275 93.31246.01NoNo068
80B:B:L286 B:B:L318 93.04814.15NoNo076
81B:B:L286 B:B:V296 93.05272.98NoYes075
82B:B:K337 B:B:W339 49.76628.12YesYes869
83B:B:K337 B:B:T50 49.59277.51YesNo063
84B:B:F335 B:B:T50 49.51563.89YesNo043
85B:B:K57 B:B:W332 46.971610.44YesYes299
86A:A:F290 A:A:I288 13.98313.77YesNo099
87A:A:D378 A:A:I288 14.53288.4NoNo079
88A:A:D378 A:A:Y360 18.75428.05NoNo078
89A:A:I244 A:A:L44 17.06114.28YesYes289
90A:A:I244 A:A:L282 17.99784.28YesNo089
91A:A:L282 A:A:N279 18.1749.61NoNo098
92A:A:I235 A:A:N279 28.4212.83NoNo098
93A:A:I235 A:A:R231 28.26113.76NoYes2599
94A:A:L272 A:A:R231 28.99983.64NoYes089
95A:A:F246 A:A:L272 29.09866.09NoNo098
96A:A:S349 A:A:T350 15.90163.2YesNo074
97A:A:F246 A:A:L289 20.55683.65NoNo099
98A:A:C359 A:A:L289 20.76233.17NoNo059
99A:A:C359 A:A:L346 13.11313.17NoYes2354
100B:B:W332 B:B:Y59 45.429411.58YesYes298
101B:B:Q75 B:B:W99 88.83025.48NoYes299
102B:B:Q75 B:B:Y59 44.10110.15NoYes298
103B:B:K57 B:B:Q75 45.03818.14YesNo299
104B:B:G162 B:B:S161 25.01873.71NoNo099
105B:B:G162 B:B:Y145 25.28062.9NoYes198
106B:B:M101 B:B:Y145 61.36042.39NoYes098
107B:B:L117 B:B:M101 61.65164.24NoNo099
108B:B:L117 B:B:W99 61.94335.69NoYes099
109A:A:K233 B:B:Y145 36.93313.58YesYes198
110A:A:K233 B:B:D228 35.32978.3YesYes199
111A:A:W281 B:B:R314 11.15344YesYes058
112B:B:F222 B:B:F253 11.548510.72YesYes186
113B:B:F253 B:B:T243 13.19967.78YesYes168
114B:B:H225 B:B:T243 30.42676.85YesYes198
115B:B:H225 B:B:S245 32.26515.58YesNo199
116B:B:S227 B:B:S245 33.89423.26NoNo169
117B:B:D228 B:B:S227 34.17072.94YesNo196
118B:B:W297 B:B:Y264 11.21614.82NoYes085
119B:B:W297 B:B:Y289 11.47144.82NoYes087
120B:B:D291 B:B:Y289 14.50715.75NoYes087
121B:B:C271 B:B:D291 15.78733.11YesNo058
122B:B:C271 B:B:D290 16.53933.11YesNo056
123B:B:I81 B:B:V71 28.44933.07NoNo078
124B:B:H91 B:B:I81 30.40395.3NoNo057
125B:B:H91 B:B:V133 31.70984.15NoNo054
126B:B:I93 B:B:V133 34.32059.22NoNo074
127B:B:I93 B:B:Y124 35.62693.63NoYes076
128B:B:S122 B:B:Y124 20.75063.82NoYes086
129B:B:E138 B:B:S122 21.07214.31YesNo068
130B:B:E138 B:B:I120 42.76852.73YesNo066
131B:B:D118 B:B:I120 43.70464.2NoNo096
132B:B:D118 B:B:S97 44.01878.83NoNo098
133B:B:S97 B:B:W99 44.3333.71NoYes089
134B:B:V135 B:B:Y124 20.75068.83NoYes046
135B:B:E138 B:B:V135 21.07212.85YesNo064
136B:B:H62 B:B:Y105 24.00323.27NoYes066
137B:B:V71 B:B:Y105 25.89145.05NoYes086
138B:B:H62 B:B:R150 23.377811.28NoNo066
139B:B:F151 B:B:Y111 12.94642.06YesYes094
140B:B:F151 B:B:I123 14.98222.51YesNo096
141B:B:L139 B:B:W169 10.876310.25YesYes098
142B:B:H142 B:B:W169 11.19477.41YesYes1598
143B:B:H142 B:B:S161 22.38119.76YesNo099
144B:B:L190 B:B:S160 20.88423NoNo056
145B:B:C148 B:B:L190 21.50584.76NoNo065
146B:B:C148 B:B:R150 22.12946.96NoNo066
147B:B:R214 B:B:V213 10.06452.62NoNo094
148B:B:R197 B:B:R214 10.71773.2NoNo059
149B:B:D212 B:B:R197 12.02485.96YesNo095
150B:B:L210 B:B:V200 14.3094.47NoNo056
151B:B:I232 B:B:V200 15.59336.14YesNo086
152B:B:I232 B:B:T243 17.00384.56YesYes088
153B:B:S160 B:B:V187 19.64496.46NoNo069
154B:B:C166 B:B:V187 19.06613.42NoNo089
155B:B:C166 B:B:S201 11.8683.44NoNo089
156A:A:F238 A:A:L44 179.74YesYes299
157A:A:N279 A:A:W281 10.65345.65NoYes085
158A:A:F238 B:B:W99 16.54789.02YesYes299
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9QXL
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRL4
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(Gs-CtGq)/Beta1/Gamma2
PDB Resolution 3.14
Date 2026-01-14
D.O.I. To be published
Net Summary
Imin 2.78
Number of Linked Nodes 828
Number of Links 950
Number of Hubs 139
Number of Links mediated by Hubs 520
Number of Communities 31
Number of Nodes involved in Communities 192
Number of Links involved in Communities 247
Path Summary
Number Of Nodes in MetaPath 159
Number Of Links MetaPath 158
Number of Shortest Paths 1388123
Length Of Smallest Path 3
Average Path Length 40.427
Length of Longest Path 75
Minimum Path Strength 1.33
Average Path Strength 5.81932
Maximum Path Strength 18.735
Minimum Path Correlation 0.7
Average Path Correlation 0.983405
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.85185
Average % Of Corr. Nodes 38.3714
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.3215
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • cellular homeostasis   • chemical homeostasis   • homeostatic process   • glucose homeostasis   • carbohydrate homeostasis   • intracellular chemical homeostasis   • intracellular glucose homeostasis   • neuromuscular process   • regulation of system process   • skeletal muscle contraction   • muscle contraction   • muscle system process   • regulation of muscle system process   • striated muscle contraction   • multicellular organismal movement   • musculoskeletal movement   • regulation of striated muscle contraction   • regulation of muscle contraction   • regulation of skeletal muscle contraction   • regulation of multicellular organismal process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • skeletal system development   • bone development   • response to pH   • cellular response to pH   • response to abiotic stimulus   • cellular response to acidic pH   • response to acidic pH   • cellular response to abiotic stimulus   • cellular response to environmental stimulus   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • positive regulation of biological process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • positive regulation of cell communication   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • positive regulation of establishment of protein localization   • localization   • establishment of localization in cell   • positive regulation of insulin secretion involved in cellular response to glucose stimulus   • positive regulation of insulin secretion   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • positive regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular response to carbohydrate stimulus   • response to glucose   • positive regulation of protein localization   • insulin secretion involved in cellular response to glucose stimulus   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • positive regulation of secretion by cell   • hormone secretion   • protein localization to extracellular region   • positive regulation of protein transport   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • positive regulation of hormone secretion   • response to monosaccharide   • response to carbohydrate   • positive regulation of secretion   • signal release   • cellular response to hexose stimulus   • cellular response to monosaccharide stimulus   • positive regulation of cellular process   • positive regulation of peptide secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cellular response to glucose stimulus   • regulation of protein transport   • positive regulation of protein secretion   • peptide transport   • response to hexose   • positive regulation of transport   • regulation of cellular localization   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • regulation of insulin secretion involved in cellular response to glucose stimulus   • hormone transport   • regulation of cell communication   • insulin secretion   • positive regulation of signaling   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • serotonin receptor signaling pathway   • adenylate cyclase-activating serotonin receptor signaling pathway   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • cell surface receptor signaling pathway   • bile acid signaling pathway   • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway   • renal system process   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • endomembrane system   • trans-Golgi network   • calcium ion binding   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • bioluminescence   • metabolic process   • generation of precursor metabolites and energy   • cytoplasmic vesicle   • intracellular vesicle
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ9HBW9
Sequence
>9QXL_Chain_R
THFAILMSS GPSIGIKDY NILTRITQL GIIISLICL AICIFTFWF 
FSEIQSTRT TIHKNLCCS LFLAELVFL VGINTNTNK LFCSIIAGL 
LHYFFLAAF AWMCIEGIH LYLIVVGVI YNKGFLHKN FYIFGYLSP 
AVVVGFSAA LGYRYYGTT KVCWLSTEN NFIWSFIGP ACLIILVNL 
LAFGVIIYK VFRHTAGLK PEVSCFENI RSCARGALA LLFLLGTTW 
IFGVLHVVH ASVVTAYLF TVSNAFQGM FIFLFLCVL SRKIQEEYY 
RL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9QXL_Chain_A
EDQRNEEKA QREANKKIE KQLQKDKQV YRATHRLLL LGADNSGKS 
TIVKQMRIL HTSGIFETK FQVDKVNFH MFDVGGQRD ERRKWIQCF 
NDVTAIIFV VDSSDYNRL QEALNLFKS IWNNRWLRT ISVILFLNK 
QDLLAEKVL AGKSKIEDY FPEFARYTT PEDATPEPG EDPRVTRAK 
YFIRDEFLR ISTASGDGR HYCYPHFTC AVDTENARR IFNDCKDII 
LQMNLREYN LVGGSGGSG G


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9QXL_Chain_B
NQIRDARKA CADATLSQI TNNIDPVGR IQMRTRRTL RGHLAKIYA 
MHWGTDSRL LVSASQDGK LIIWDSYTT NKVHAIPLR SSWVMTCAY 
APSGNYVAC GGLDNICSI YNLKTREGN VRVSRELAG HTGYLSCCR 
FLDDNQIVT SSGDTTCAL WDIETGQQT TTFTGHTGD VMSLSLAPD 
TRLFVSGAC DASAKLWDV REGMCRQTF TGHESDINA ICFFPNGNA 
FATGSDDAT CRLFDLRAD QELMTYSHD NIICGITSV SFSKSGRLL 
LAGYDDFNC NVWDALKAD RAGVLAGHD NRVSCLGVT DDGMAVATG 
SWDSFLKIW N


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9QXL_Chain_G
ANIDRIKVS KAAADLMAY CEAHAKEDP LLTPVPASE NPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9QXLB2AdhesionAdhesionADGRL4Homo sapiens--chim(Gs-CtGq)/β1/γ23.142026-01-14To be published
9QXL (No Gprot) B2AdhesionAdhesionADGRL4Homo sapiens--3.142026-01-14To be published




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Download 9QXL.zip



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