psnGPCR

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Orange: nodes, hubs and links specific of alpha_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alpha_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	alpha_off Int. Strength	alpha_on Int. Strength	alpha_off Hub1?	alpha_on Hub1?	alpha_off Hub2?	alpha_on Hub2?	ConSurf1	ConSurf2
1	1x53	7x53	alpha_off	100	0	No	No	Yes	Yes	9	9
2	1x60	I1x49	alpha_off	100	0	No	No	No	No	6	6
3	I1x49	I1x50	alpha_off	100	0	No	No	No	Yes	6	8
4	2x39	3x50	alpha_off	100	0	No	No	Yes	Yes	8	9
5	2x40	2x43	alpha_off	100	0	No	No	No	No	8	7
6	2x42	3x46	alpha_off	100	0	Yes	Yes	No	No	8	9
7	2x42	4x46	alpha_off	100	0	Yes	Yes	No	No	8	8
8	2x43	7x53	alpha_off	100	0	No	No	Yes	Yes	7	9
9	2x53	2x56	alpha_off	100	0	No	No	No	Yes	8	8
10	2x59	3x24	alpha_off	100	0	No	No	No	No	5	5
11	3x28	Lig	alpha_off	100	0	Yes	Yes	Yes	Yes	5	0
12	3x37	4x57	alpha_off	100	0	Yes	No	Yes	No	7	8
13	3x39	6x44	alpha_off	100	0	No	No	Yes	Yes	9	9
14	3x40	6x44	alpha_off	100	0	No	No	Yes	Yes	8	9
15	3x41	4x53	alpha_off	100	0	No	No	No	No	6	8
16	3x41	5x50	alpha_off	100	0	No	No	No	No	6	9
17	3x43	6x41	alpha_off	100	0	No	Yes	Yes	No	8	8
18	3x49	3x50	alpha_off	100	0	Yes	Yes	Yes	Yes	9	9
19	5x54	6x41	alpha_off	100	0	No	No	Yes	No	8	8
20	I3	I3	alpha_off	100	0	Yes	No	Yes	No	3	3
21	6x39	7x52	alpha_off	100	0	No	No	No	No	7	8
22	6x40	7x52	alpha_off	100	0	No	No	No	No	8	8
23	6x48	6x51	alpha_off	100	0	Yes	Yes	Yes	Yes	8	7
24	6x54	E3	alpha_off	100	0	No	No	Yes	Yes	5	3
25	7x34	Lig	alpha_off	100	0	No	No	Yes	Yes	4	0
26	7x49	7x53	alpha_off	100	0	Yes	Yes	Yes	Yes	9	9
27	7x53	8x50	alpha_off	100	0	Yes	Yes	Yes	Yes	9	8
28	8x50	8x54	alpha_off	100	0	Yes	Yes	Yes	No	8	7
29	Lig	Lig	alpha_off	100	0	Yes	Yes	Yes	Yes	0	0
30	E2	Lig	alpha_off	100	0	Yes	Yes	Yes	Yes	4	0
31	E2x51	Lig	alpha_off	100	0	No	No	Yes	Yes	5	0
32	E2x52	Lig	alpha_off	100	0	No	No	Yes	Yes	6	0
33	2x551	3x31	alpha_off	100	0	No	No	No	No	6	5
34	E1x49	E2	alpha_off	100	0	No	No	Yes	Yes	4	4
35	3x43	5x54	alpha_off	100	0	No	Yes	No	No	8	8
36	I2x50	I2x51	alpha_off	100	0	No	No	No	No	8	7
37	6x40	7x49	alpha_off	100	0	No	No	Yes	Yes	8	9
38	6x44	7x45	alpha_off	100	0	Yes	Yes	No	No	9	9
39	7x34	E3	alpha_off	100	0	No	No	Yes	Yes	4	3
40	7x30	7x33	alpha_off	100	0	No	No	No	No	5	5
41	NT	NT	alpha_off	100	0	Yes	No	Yes	No	0	0
42	4x39	I1x48	alpha_off	100	0	No	No	No	No	4	7
43	2x63	E1x51	alpha_off	100	0	No	No	Yes	No	4	3
44	E1x51	E2x50	alpha_off	100	0	Yes	No	No	No	3	9
45	3x50	6x33	alpha_off	100	0	Yes	Yes	No	No	9	0
46	3x50	6x34	alpha_off	100	0	Yes	Yes	No	No	9	0
47	3x50	6x37	alpha_off	100	0	Yes	Yes	No	No	9	0
48	5x58	6x38	alpha_off	100	0	Yes	Yes	No	No	9	0
49	3x24	E1x51	alpha_off	100	0	No	No	Yes	No	5	3
50	I2x54	I2x57	alpha_off	100	0	No	No	Yes	No	6	6
51	4x41	I2x56	alpha_off	100	0	No	No	No	No	6	5
52	6x33	6x37	alpha_off	100	0	No	No	No	No	0	0
53	E2	NT	alpha_off	100	0	Yes	Yes	Yes	No	4	0
54	4x58	4x60	alpha_off	100	0	No	No	No	No	4	7
55	5x48	6x56	alpha_off	75	0	No	No	No	No	6	6
56	5x58	I3	alpha_off	50	0	Yes	Yes	Yes	No	9	3
57	5x51	6x45	alpha_off	50	0	No	No	No	No	6	5
58	6x29	8x49	alpha_off	50	0	No	No	No	No	0	7
59	5x68	6x27	alpha_off	50	0	No	No	No	No	7	0
60	3x51	5x61	alpha_off	75	0	Yes	No	No	No	8	9
61	3x29	E2x52	alpha_off	50	0	No	No	No	No	6	6
62	2x41	4x42	alpha_off	50	0	No	No	No	No	5	7
63	1x42	1x46	alpha_off	50	0	No	No	Yes	No	7	8
64	6x30	I2x53	alpha_off	50	0	No	No	Yes	Yes	0	7
65	5x36	5x38	alpha_off	50	0	No	No	No	No	6	5
66	6x39	7x56	alpha_off	25	0	No	No	No	No	7	7
67	5x76	I3	alpha_off	50	0	No	No	Yes	No	2	3
68	1x42	7x43	alpha_off	25	0	No	No	No	No	7	5
69	1x60	8x53	alpha_off	75	0	No	No	No	No	6	7
70	5x71	I3	alpha_off	50	0	No	No	Yes	No	4	3
71	5x72	I3	alpha_off	50	0	No	No	Yes	No	6	3
72	6x58	6x62	alpha_off	50	0	No	No	No	No	4	0
73	1x46	2x54	alpha_off	25	0	Yes	No	No	No	8	7
74	1x54	2x44	alpha_off	0	0	Yes	No	No	No	7	6
75	I2x52	I2x56	alpha_off	50	0	No	No	No	No	5	5
76	1x46	7x46	alpha_off	25	0	Yes	No	No	No	8	9
77	1x34	NT	alpha_off	50	0	Yes	No	Yes	No	4	0
78	4x62	E2	alpha_off	50	0	No	No	Yes	Yes	4	4
79	I2x51	I3	alpha_off	50	0	No	No	Yes	No	7	3
80	4x40	4x43	alpha_off	50	0	No	No	No	No	5	5
81	4x43	4x46	alpha_off	25	0	No	No	No	No	5	8
82	6x26	6x29	alpha_off	50	0	No	No	No	No	0	0
83	3x23	3x27	alpha_off	25	0	No	No	No	No	3	5
84	2x49	3x39	alpha_off	25	0	No	No	No	No	8	9
85	5x64	5x68	alpha_off	0	0	No	No	No	No	6	7
86	3x44	5x54	alpha_off	0	0	No	No	No	No	6	8
87	5x65	6x31	alpha_off	0	0	No	No	Yes	No	8	0
88	3x24	3x27	alpha_off	25	0	No	No	No	No	5	5
89	4x60	5x42	alpha_off	50	0	No	No	No	No	7	5
90	5x69	6x31	alpha_off	50	0	No	No	Yes	No	5	0
91	6x36	7x53	alpha_off	25	0	No	No	Yes	Yes	0	9
92	6x60	E3	alpha_off	25	0	No	No	Yes	Yes	5	3
93	5x45	5x49	alpha_off	25	0	No	No	No	No	4	5
94	6x28	6x31	alpha_off	25	0	No	No	Yes	No	0	0
95	5x37	5x38	alpha_off	25	0	No	No	No	No	4	5
96	3x21	E2	alpha_off	50	0	No	No	Yes	Yes	8	4
97	8x52	8x56	alpha_off	25	0	No	No	No	No	5	5
98	8x56	CT	alpha_off	25	0	No	No	No	No	5	7
99	6x29	6x32	alpha_off	0	0	No	No	No	No	0	0
100	1x48	1x52	alpha_off	0	0	No	No	Yes	No	4	7
101	1x34	1x35	alpha_off	0	0	Yes	No	No	No	4	5
102	5x58	5x62	alpha_off	25	0	Yes	Yes	No	No	9	5
103	1x30	1x33	alpha_off	25	0	No	No	No	No	4	6
104	8x56	8x60	alpha_off	25	0	No	No	No	No	5	0
105	1x41	1x45	alpha_off	0	0	No	No	Yes	No	5	5
106	5x70	I3	alpha_off	25	0	No	No	Yes	No	5	3
107	8x55	8x59	alpha_off	25	0	No	No	No	No	5	5
108	5x74	I3	alpha_off	25	0	No	No	Yes	No	4	3
109	1x36	2x61	alpha_off	0	0	No	No	No	No	6	6
110	1x38	7x39	alpha_off	25	0	No	No	Yes	No	5	6
111	1x55	1x59	alpha_off	0	0	No	No	No	No	4	5
112	4x64	5x39	alpha_off	25	0	No	No	No	Yes	6	8
113	7x31	7x32	alpha_off	0	0	No	No	No	No	2	1
114	3x30	4x59	alpha_off	0	0	No	No	No	No	6	7
115	6x25	6x26	alpha_off	25	0	No	No	No	No	0	0
116	1x44	1x45	alpha_off	25	0	No	No	Yes	No	4	5
117	1x33	1x37	alpha_off	0	0	No	No	No	No	6	5
118	6x43	6x46	alpha_off	0	0	No	No	No	No	7	5
119	2x67	E1x50	alpha_off	0	0	No	No	Yes	Yes	4	8
120	1x34	1x37	alpha_off	0	0	Yes	No	No	No	4	5
121	5x70	5x75	alpha_off	12.5	0	No	No	No	No	5	2
122	5x70	5x73	alpha_off	12.5	0	No	No	No	No	5	4
123	1x28	1x31	alpha_off	0	0	No	No	No	No	0	3
124	1x39	2x61	Shared	100	100	No	No	No	No	7	6
125	1x45	7x51	Shared	100	50	Yes	No	No	No	5	6
126	1x49	7x50	Shared	100	66.6667	No	No	No	No	9	9
127	1x50	2x50	Shared	100	100	Yes	Yes	Yes	Yes	9	9
128	1x50	7x50	Shared	100	100	Yes	Yes	No	No	9	9
129	1x51	2x51	Shared	100	58.3333	No	No	No	No	4	7
130	1x52	8x54	Shared	100	100	Yes	No	Yes	No	7	7
131	1x57	2x44	Shared	100	100	No	No	No	No	8	6
132	1x60	I1x50	Shared	100	100	No	No	No	Yes	6	8
133	I1x48	I1x51	Shared	100	33.3333	No	No	No	No	7	8
134	2x39	3x49	Shared	100	100	No	No	Yes	Yes	8	9
135	2x42	4x42	Shared	100	100	Yes	Yes	No	No	8	7
136	2x45	4x46	Shared	100	100	No	No	No	No	9	8
137	2x45	4x50	Shared	100	100	No	No	No	No	9	9
138	2x50	3x39	Shared	100	100	Yes	Yes	No	No	9	9
139	2x50	7x49	Shared	100	100	Yes	Yes	Yes	Yes	9	9
140	2x53	3x35	Shared	100	100	No	No	No	No	8	6
141	2x53	7x46	Shared	100	100	No	No	No	No	8	9
142	2x56	3x32	Shared	100	100	No	Yes	No	No	8	7
143	2x57	7x42	Shared	100	100	No	No	Yes	Yes	8	7
144	2x59	3x28	Shared	100	100	No	No	Yes	Yes	5	5
145	2x60	3x28	Shared	100	100	No	No	Yes	Yes	7	5
146	2x63	E1x50	Shared	100	58.3333	No	No	Yes	Yes	4	8
147	2x64	7x35	Shared	100	100	No	No	No	No	5	5
148	E1x49	E1x51	Shared	100	16.6667	No	No	Yes	No	4	3
149	E1x50	E1x52	Shared	100	100	Yes	Yes	No	No	8	5
150	3x28	E1x50	Shared	100	100	Yes	Yes	Yes	Yes	5	8
151	E1x50	E2x50	Shared	100	100	Yes	Yes	No	No	8	9
152	3x22	E2	Shared	100	100	No	No	Yes	Yes	5	4
153	3x25	E2x50	Shared	100	100	No	No	No	No	9	9
154	3x31	3x35	Shared	100	50	No	No	No	No	5	6
155	3x32	7x42	Shared	100	100	No	No	Yes	Yes	7	7
156	3x32	Lig	Shared	100	100	No	No	Yes	Yes	7	0
157	3x33	4x57	Shared	100	75	No	No	Yes	No	6	8
158	3x33	Lig	Shared	100	100	No	No	Yes	Yes	6	0
159	3x34	4x57	Shared	100	100	No	No	Yes	No	6	8
160	3x36	6x48	Shared	100	100	No	No	Yes	Yes	6	8
161	3x37	4x53	Shared	100	100	Yes	No	No	No	7	8
162	3x37	4x56	Shared	100	100	Yes	No	No	No	7	6
163	3x37	5x461	Shared	100	100	Yes	No	No	No	7	6
164	3x38	4x50	Shared	100	100	No	No	No	No	8	9
165	3x38	4x53	Shared	100	33.3333	No	No	No	No	8	8
166	3x40	5x50	Shared	100	33.3333	No	No	No	No	8	9
167	3x43	6x44	Shared	100	100	No	Yes	Yes	Yes	8	9
168	3x44	5x53	Shared	100	100	No	No	No	No	6	6
169	3x49	I2x53	Shared	100	100	Yes	Yes	Yes	Yes	9	7
170	3x49	I2x57	Shared	100	100	Yes	Yes	Yes	No	9	6
171	3x51	3x55	Shared	100	100	Yes	No	No	No	8	7
172	3x53	I2x53	Shared	100	54.1667	No	No	Yes	Yes	8	7
173	3x55	3x56	Shared	100	100	No	No	No	Yes	7	6
174	I2x53	I2x57	Shared	100	100	Yes	Yes	Yes	No	7	6
175	4x59	4x60	Shared	100	100	No	No	No	No	7	7
176	E2	E2	Shared	100	100	Yes	Yes	Yes	Yes	4	4
177	5x36	E2	Shared	100	100	No	No	Yes	Yes	6	4
178	5x39	E2	Shared	100	100	No	Yes	Yes	Yes	8	4
179	5x39	5x43	Shared	100	100	No	Yes	No	No	8	7
180	5x40	6x55	Shared	100	100	No	No	No	No	6	7
181	5x40	6x59	Shared	100	100	No	No	No	No	6	5
182	5x44	6x52	Shared	100	50	No	No	Yes	Yes	7	7
183	5x47	5x48	Shared	100	100	Yes	Yes	No	No	8	6
184	5x47	5x51	Shared	100	100	Yes	Yes	No	No	8	6
185	5x47	6x49	Shared	100	100	Yes	Yes	No	Yes	8	7
186	5x47	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
187	5x58	5x61	Shared	100	25	Yes	Yes	No	No	9	9
188	6x43	7x52	Shared	100	100	No	No	No	No	7	8
189	6x44	6x48	Shared	100	100	Yes	Yes	Yes	Yes	9	8
190	6x47	7x45	Shared	100	100	No	No	No	No	8	9
191	6x48	6x52	Shared	100	100	Yes	Yes	Yes	Yes	8	7
192	6x48	7x41	Shared	100	100	Yes	Yes	No	No	8	7
193	6x51	6x52	Shared	100	100	Yes	Yes	Yes	Yes	7	7
194	6x51	6x55	Shared	100	100	Yes	Yes	No	No	7	7
195	6x51	7x38	Shared	100	100	Yes	Yes	No	No	7	6
196	6x51	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
197	6x52	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
198	6x54	7x37	Shared	100	100	No	No	No	No	5	5
199	6x61	E3	Shared	100	100	No	No	Yes	Yes	4	3
200	E3	E3	Shared	100	100	Yes	Yes	Yes	Yes	3	3
201	7x31	7x35	Shared	100	0	No	No	No	No	2	5
202	7x38	7x42	Shared	100	100	No	No	Yes	Yes	6	7
203	7x38	Lig	Shared	100	100	No	No	Yes	Yes	6	0
204	7x39	7x42	Shared	100	100	Yes	No	Yes	Yes	6	7
205	7x42	Lig	Shared	100	100	Yes	Yes	Yes	Yes	7	0
206	7x54	8x54	Shared	100	100	No	No	Yes	No	7	7
207	7x55	7x56	Shared	100	50	No	No	No	No	5	7
208	8x47	8x50	Shared	100	100	No	No	Yes	Yes	8	8
209	2x38	4x39	Shared	100	62.5	No	No	No	No	7	4
210	2x45	3x42	Shared	100	50	No	No	No	No	9	7
211	2x50	7x46	Shared	100	100	Yes	Yes	No	No	9	9
212	2x52	3x35	Shared	100	100	No	No	No	No	6	6
213	3x42	4x49	Shared	100	50	No	No	No	No	7	6
214	3x47	5x57	Shared	100	100	No	No	No	No	9	6
215	3x51	5x60	Shared	100	100	Yes	No	No	No	8	6
216	3x52	I2x53	Shared	100	100	No	Yes	Yes	Yes	5	7
217	E2	E2x51	Shared	100	100	Yes	Yes	No	No	4	5
218	6x49	6x53	Shared	100	100	No	Yes	No	No	7	6
219	6x50	7x37	Shared	100	100	No	No	No	No	9	5
220	2x60	7x42	Shared	100	100	No	No	Yes	Yes	7	7
221	5x62	5x66	Shared	100	100	No	No	No	No	5	5
222	6x27	6x31	Shared	100	37.5	No	No	Yes	No	0	0
223	6x57	E3	Shared	100	75	No	No	Yes	Yes	5	3
224	6x58	E3	Shared	100	75	No	No	Yes	Yes	4	3
225	2x39	I2x57	Shared	100	100	No	No	Yes	No	8	6
226	3x48	3x52	Shared	50	100	No	No	No	Yes	6	5
227	1x50	2x47	Shared	75	50	Yes	Yes	No	No	9	9
228	3x41	4x52	Shared	75	50	No	No	No	No	6	5
229	2x37	2x40	Shared	50	100	No	No	No	No	7	8
230	5x58	6x41	Shared	75	58.3333	Yes	Yes	Yes	No	9	8
231	1x46	7x47	Shared	62.5	100	Yes	No	No	No	8	6
232	1x43	2x58	Shared	62.5	33.3333	No	No	No	No	5	9
233	4x57	4x58	Shared	50	25	Yes	No	No	No	8	4
234	2x46	7x49	Shared	50	100	No	No	Yes	Yes	9	9
235	3x26	E2	Shared	50	12.5	No	No	Yes	Yes	6	4
236	2x42	4x45	Shared	50	50	Yes	Yes	No	No	8	6
237	2x42	3x49	Shared	75	100	Yes	Yes	Yes	Yes	8	9
238	7x33	7x37	Shared	50	50	No	No	No	No	5	5
239	3x51	5x57	Shared	50	100	Yes	No	No	No	8	6
240	2x55	2x551	Shared	75	66.6667	No	No	No	No	5	6
241	4x38	4x41	Shared	75	29.1667	No	No	No	No	7	6
242	2x64	7x39	Shared	50	100	No	No	Yes	No	5	6
243	2x42	3x45	Shared	50	100	Yes	Yes	No	No	8	7
244	2x41	4x39	Shared	50	50	No	No	No	No	5	4
245	1x39	7x39	Shared	75	100	No	No	Yes	No	7	6
246	1x43	2x57	Shared	25	100	No	No	No	No	5	8
247	8x50	I1x50	Shared	50	100	Yes	Yes	No	Yes	8	8
248	6x35	6x39	Shared	50	62.5	No	No	No	No	0	7
249	3x56	I2x52	Shared	50	100	No	Yes	No	No	6	5
250	8x47	8x49	Shared	50	50	No	No	No	No	8	7
251	1x54	2x47	Shared	50	25	Yes	No	No	No	7	9
252	1x56	8x54	Shared	50	37.5	No	No	Yes	No	8	7
253	2x61	2x65	Shared	50	25	No	No	No	No	6	5
254	3x54	5x61	Shared	50	29.1667	No	No	No	No	8	9
255	1x50	2x51	Shared	0	100	Yes	Yes	No	No	9	7
256	5x41	6x60	Shared	25	16.6667	No	No	No	No	6	5
257	8x48	8x51	Shared	37.5	20.8333	No	No	No	No	5	8
258	1x47	2x54	Shared	50	25	No	No	No	No	6	7
259	1x52	8x58	Shared	25	41.6667	Yes	No	No	No	7	7
260	1x55	8x57	Shared	12.5	50	No	No	No	No	4	6
261	5x49	5x50	Shared	25	54.1667	No	No	No	No	5	9
262	3x54	5x64	Shared	0	50	No	No	No	No	8	6
263	4x43	4x47	Shared	25	0	No	No	No	No	5	4
264	1x52	8x57	Shared	0	33.3333	Yes	No	No	No	7	6
265	8x48	8x49	Shared	50	50	No	No	No	No	5	7
266	3x34	4x54	Shared	25	0	No	No	No	No	6	4
267	5x67	5x68	Shared	25	12.5	No	No	No	No	5	7
268	7x43	7x48	Shared	50	12.5	No	No	No	No	5	6
269	5x51	5x55	Shared	50	50	No	No	No	No	6	5
270	7x36	7x40	Shared	25	100	No	No	No	No	5	7
271	1x45	7x47	Shared	25	33.3333	Yes	No	No	No	5	6
272	8x58	8x59	Shared	25	4.16667	No	No	No	No	7	5
273	1x32	2x65	Shared	0	8.33333	No	No	No	No	4	5
274	2x62	2x66	Shared	12.5	50	No	No	No	No	5	5
275	6x50	7x40	Shared	25	12.5	No	No	No	No	9	7
276	1x54	2x48	Shared	0	12.5	Yes	No	No	No	7	6
277	1x31	1x34	Shared	50	8.33333	No	No	Yes	No	3	4
278	5x45	5x46	Shared	0	25	No	No	No	No	4	5
279	4x47	4x51	Shared	0	0	No	No	No	No	4	4
280	8x48	8x52	Shared	25	100	No	No	No	No	5	5
281	I2x52	I2x55	Shared	25	0	No	No	No	No	5	4
282	5x52	5x56	Shared	0	8.33333	No	No	No	No	4	4
283	3x26	4x61	Shared	25	12.5	No	No	No	No	6	5
284	1x40	1x43	Shared	0	16.6667	No	No	No	No	3	5
285	2x66	E1x49	Shared	25	100	No	No	No	No	5	4
286	4x40	4x44	Shared	25	12.5	No	No	No	No	5	3
287	1x54	1x58	Shared	0	4.16667	Yes	No	No	No	7	2
288	6x41	6x42	Shared	0	0	Yes	No	No	No	8	5
289	5x56	5x60	Shared	0	54.1667	No	No	No	No	4	6
290	5x60	5x63	Shared	0	25	No	No	No	No	6	4
291	1x33	1x34	Shared	0	0	No	No	Yes	No	6	4
292	5x55	5x59	Shared	0	0	No	No	No	No	5	3
293	4x48	4x52	Shared	0	4.16667	No	No	No	No	2	5
294	4x62	4x63	Shared	0	25	No	No	No	No	4	5
295	2x40	I1x50	alpha_on	0	100	No	No	No	Yes	8	8
296	2x40	8x50	alpha_on	0	100	No	No	Yes	Yes	8	8
297	2x46	2x50	alpha_on	0	100	No	No	Yes	Yes	9	9
298	2x46	3x43	alpha_on	0	100	No	No	No	Yes	9	8
299	2x56	3x28	alpha_on	0	100	No	Yes	Yes	Yes	8	5
300	2x56	7x42	alpha_on	0	100	No	Yes	Yes	Yes	8	7
301	2x59	E1x52	alpha_on	0	100	No	No	No	No	5	5
302	3x25	E1x50	alpha_on	0	100	No	No	Yes	Yes	9	8
303	3x36	Lig	alpha_on	0	100	No	No	Yes	Yes	6	0
304	3x40	6x48	alpha_on	0	100	No	No	Yes	Yes	8	8
305	3x41	4x49	alpha_on	0	100	No	No	No	No	6	6
306	3x43	7x49	alpha_on	0	100	No	Yes	Yes	Yes	8	9
307	3x43	7x53	alpha_on	0	100	No	Yes	Yes	Yes	8	9
308	3x46	3x50	alpha_on	0	100	No	No	Yes	Yes	9	9
309	3x46	7x53	alpha_on	0	100	No	No	Yes	Yes	9	9
310	3x47	5x54	alpha_on	0	100	No	No	No	No	9	8
311	3x47	5x58	alpha_on	0	100	No	No	Yes	Yes	9	9
312	3x50	5x58	alpha_on	0	100	Yes	Yes	Yes	Yes	9	9
313	3x50	7x53	alpha_on	0	100	Yes	Yes	Yes	Yes	9	9
314	4x60	E2	alpha_on	0	100	No	No	Yes	Yes	7	4
315	4x60	5x39	alpha_on	0	100	No	No	No	Yes	7	8
316	4x64	5x36	alpha_on	0	100	No	No	No	No	6	6
317	E2	E2x52	alpha_on	0	100	Yes	Yes	No	No	4	6
318	5x43	Lig	alpha_on	0	100	No	No	Yes	Yes	7	0
319	5x47	6x44	alpha_on	0	100	Yes	Yes	Yes	Yes	8	9
320	5x51	6x44	alpha_on	0	100	No	No	Yes	Yes	6	9
321	5x54	6x44	alpha_on	0	100	No	No	Yes	Yes	8	9
322	5x58	6x40	alpha_on	0	100	Yes	Yes	No	No	9	8
323	5x62	6x34	alpha_on	0	100	No	No	No	No	5	0
324	5x65	6x33	alpha_on	0	100	No	No	No	No	8	0
325	5x66	6x30	alpha_on	0	100	No	No	No	No	5	0
326	6x48	7x45	alpha_on	0	100	Yes	Yes	No	No	8	9
327	6x48	Lig	alpha_on	0	100	Yes	Yes	Yes	Yes	8	0
328	6x55	Lig	alpha_on	0	100	No	No	Yes	Yes	7	0
329	7x45	7x49	alpha_on	0	100	No	No	Yes	Yes	9	9
330	7x52	7x53	alpha_on	0	100	No	No	Yes	Yes	8	9
331	7x54	8x50	alpha_on	0	100	No	No	Yes	Yes	7	8
332	3x52	3x56	alpha_on	0	100	No	Yes	No	Yes	5	6
333	5x58	6x37	alpha_on	0	100	Yes	Yes	No	No	9	0
334	6x36	7x56	alpha_on	0	100	No	No	No	No	0	7
335	6x49	6x50	alpha_on	0	75	No	Yes	No	No	7	9
336	6x30	6x33	alpha_on	0	50	No	No	No	No	0	0
337	5x69	6x29	alpha_on	0	50	No	No	No	No	5	0
338	2x54	2x57	alpha_on	0	58.3333	No	No	No	No	7	8
339	5x64	5x67	alpha_on	0	75	No	No	No	No	6	5
340	5x44	6x56	alpha_on	0	50	No	No	No	No	7	6
341	8x49	I1x49	alpha_on	0	62.5	No	No	No	No	7	6
342	2x38	2x42	alpha_on	0	50	No	No	Yes	Yes	7	8
343	2x37	2x39	alpha_on	0	54.1667	No	No	No	No	7	8
344	5x67	6x29	alpha_on	0	50	No	No	No	No	5	0
345	1x53	7x54	alpha_on	0	54.1667	No	No	No	No	9	7
346	6x43	7x48	alpha_on	0	41.6667	No	No	No	No	7	6
347	6x45	6x49	alpha_on	0	37.5	No	No	No	Yes	5	7
348	2x43	8x50	alpha_on	0	37.5	No	No	Yes	Yes	7	8
349	5x461	Lig	alpha_on	0	62.5	No	No	Yes	Yes	6	0
350	6x51	7x34	alpha_on	0	50	Yes	Yes	No	No	7	4
351	3x44	5x50	alpha_on	0	29.1667	No	No	No	No	6	9
352	7x30	7x31	alpha_on	0	50	No	No	No	No	5	2
353	5x62	6x37	alpha_on	0	4.16667	No	No	No	No	5	0
354	8x52	8x55	alpha_on	0	62.5	No	No	No	No	5	5
355	I2x53	I2x54	alpha_on	0	50	Yes	Yes	No	No	7	6
356	6x32	6x36	alpha_on	0	41.6667	No	No	No	No	0	0
357	2x49	4x50	alpha_on	0	8.33333	No	No	No	No	8	9
358	5x69	6x26	alpha_on	0	50	No	No	No	No	5	0
359	2x551	2x56	alpha_on	0	29.1667	No	No	No	Yes	6	8
360	6x53	6x57	alpha_on	0	50	No	No	No	No	6	5
361	7x30	7x32	alpha_on	0	50	No	No	No	No	5	1
362	3x24	E1x52	alpha_on	0	37.5	No	No	No	No	5	5
363	1x57	I1x50	alpha_on	0	50	No	No	No	Yes	8	8
364	5x37	6x60	alpha_on	0	37.5	No	No	No	No	4	5
365	6x60	6x61	alpha_on	0	20.8333	No	No	No	No	5	4
366	1x59	1x60	alpha_on	0	50	No	No	No	No	5	6
367	1x46	1x50	alpha_on	0	12.5	Yes	No	Yes	Yes	8	9
368	4x41	I2x53	alpha_on	0	50	No	No	Yes	Yes	6	7
369	3x23	3x24	alpha_on	0	29.1667	No	No	No	No	3	5
370	5x38	5x39	alpha_on	0	50	No	No	No	Yes	5	8
371	2x41	4x43	alpha_on	0	4.16667	No	No	No	No	5	5
372	3x50	7x56	alpha_on	0	50	Yes	Yes	No	No	9	7
373	3x21	E1x50	alpha_on	0	50	No	No	Yes	Yes	8	8
374	I2x51	I2x52	alpha_on	0	16.6667	No	No	No	No	7	5
375	3x52	I2x56	alpha_on	0	33.3333	No	Yes	No	No	5	5
376	5x45	5x48	alpha_on	0	25	No	No	No	No	4	6
377	3x30	4x61	alpha_on	0	12.5	No	No	No	No	6	5
378	1x48	1x49	alpha_on	0	4.16667	No	No	No	No	4	9
379	E1x49	E1x50	alpha_on	0	25	No	No	Yes	Yes	4	8
380	4x56	5x42	alpha_on	0	12.5	No	No	No	No	6	5
381	3x28	3x29	alpha_on	0	8.33333	Yes	Yes	No	No	5	6
382	1x56	8x53	alpha_on	0	12.5	No	No	No	No	8	7
383	1x42	7x47	alpha_on	0	4.16667	No	No	No	No	7	6
384	3x26	3x27	alpha_on	0	20.8333	No	No	No	No	6	5
385	4x62	4x64	alpha_on	0	12.5	No	No	No	No	4	6
386	2x66	2x67	alpha_on	0	4.16667	No	No	No	No	5	4
387	4x38	4x40	alpha_on	0	8.33333	No	No	No	No	7	5
388	1x40	1x41	alpha_on	0	0	No	No	No	No	3	5
389	6x31	6x35	alpha_on	0	12.5	Yes	No	No	No	0	0
390	1x60	8x56	alpha_on	0	12.5	No	No	No	No	6	5
391	6x39	6x43	alpha_on	0	0	No	No	No	No	7	7
392	I1x48	I1x50	alpha_on	0	12.5	No	No	No	Yes	7	8
393	1x36	2x65	alpha_on	0	0	No	No	No	No	6	5
394	1x31	1x35	alpha_on	0	16.6667	No	No	No	No	3	5
395	1x35	1x39	alpha_on	0	0	No	No	No	No	5	7
396	6x28	6x32	alpha_on	0	8.33333	No	No	No	No	0	0
397	3x56	I2x50	alpha_on	0	0	No	Yes	No	No	6	8
398	1x30	1x32	alpha_on	0	12.5	No	No	No	No	4	4
399	6x46	6x47	alpha_on	0	4.16667	No	No	No	No	5	8
400	6x38	6x41	alpha_on	0	0	No	No	Yes	No	0	8
401	1x44	1x47	alpha_on	0	0	No	No	No	No	4	6
402	1x37	1x38	alpha_on	0	0	No	No	No	No	5	5
403	4x52	4x55	alpha_on	0	4.16667	No	No	No	No	5	4
404	1x36	1x37	alpha_on	0	8.33333	No	No	No	No	6	5
405	6x25	6x28	alpha_on	0	0	No	No	No	No	0	0
406	6x23	6x26	alpha_on	0	4.16667	No	No	No	No	0	0
407	1x29	1x30	alpha_on	0	4.16667	No	No	No	No	0	4
408	6x24	6x25	alpha_on	0	0	No	No	No	No	0	0
409	5x70	6x26	alpha_on	0	4.16667	No	No	No	No	5	0
410	6x22	6x24	alpha_on	0	0	No	No	No	No	0	0

Orange: nodes, hubs and links specific of alpha_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alpha_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	alpha_off Avg Int. Strength	alpha_on Avg Int. Strength	alpha_off Num Of Links	alpha_on Num Of Links	ConSurf
1	1x34	alpha_off	0	0	5	2	4
2	1x45	alpha_off	0	0	4	2	5
3	1x46	alpha_off	0	0	4	2	8
4	1x52	alpha_off	0	0	4	3	7
5	1x54	alpha_off	0	0	4	3	7
6	E1x51	alpha_off	25	0	4	1	3
7	3x37	alpha_off	0	0	4	3	7
8	3x51	alpha_off	25	25	4	3	8
9	I2x57	alpha_off	25	62.5	4	3	6
10	4x57	alpha_off	0	0	4	3	8
11	I3	alpha_off	25	0	9	0	3
12	6x41	alpha_off	0	0	4	3	8
13	7x39	alpha_off	0	25	4	3	6
14	8x54	alpha_off	0	0	4	3	7
15	NT	alpha_off	25	0	4	0	0
16	6x31	alpha_off	0	0	4	2	0
17	1x50	Shared	0	25	4	5	9
18	2x42	Shared	87.5	25	6	5	8
19	2x50	Shared	12.5	50	4	5	9
20	E1x50	Shared	25	37.5	5	7	8
21	3x28	Shared	87.5	12.5	4	5	5
22	3x49	Shared	50	25	5	4	9
23	3x50	Shared	50	25	5	4	9
24	I2x53	Shared	50	62.5	5	6	7
25	E2	Shared	100	50	12	9	4
26	5x47	Shared	50	95.8333	4	5	8
27	5x58	Shared	0	95.8333	5	6	9
28	6x44	Shared	50	62.5	5	5	9
29	6x48	Shared	100	100	5	7	8
30	6x51	Shared	100	58.3333	5	5	7
31	6x52	Shared	75	91.6667	5	5	7
32	E3	Shared	62.5	25	8	5	3
33	7x42	Shared	75	95.8333	6	7	7
34	7x49	Shared	25	83.3333	4	4	9
35	7x53	Shared	0	83.3333	5	4	9
36	8x50	Shared	50	25	4	5	8
37	Lig	Shared	100	100	13	11	0
38	I1x50	alpha_on	0	0	3	5	8
39	2x56	alpha_on	0	0	2	4	8
40	3x43	alpha_on	0	25	3	4	8
41	3x52	alpha_on	0	25	2	4	5
42	3x56	alpha_on	0	0	2	4	6
43	5x39	alpha_on	37.5	37.5	3	4	8
44	6x49	alpha_on	0	0	2	4	7

Orange: nodes, hubs and links specific of alpha_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of alpha_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	alpha_off Recurrence	alpha_on Recurrence	alpha_off Hub1?	alpha_on Hub1?	alpha_off Hub2?	alpha_on Hub2?	ConSurf1	ConSurf2
1	2x53	2x56	alpha_off	35.5301	0	No	No	No	Yes	8	8
2	2x53	7x46	alpha_off	34.9838	8.4583	No	No	No	No	8	9
3	1x46	7x46	alpha_off	17.2728	0	Yes	No	No	No	8	9
4	7x49	7x53	alpha_off	60.4234	0	Yes	Yes	Yes	Yes	9	9
5	1x50	2x47	alpha_off	13.4141	8.4583	Yes	Yes	No	No	9	9
6	1x54	2x47	alpha_off	11.206	6.35541	Yes	No	No	No	7	9
7	7x53	8x50	alpha_off	49.7012	0	Yes	Yes	Yes	Yes	9	8
8	3x33	Lig	alpha_off	40.4359	7.15408	No	No	Yes	Yes	6	0
9	3x33	4x57	alpha_off	38.7229	5.73941	No	No	Yes	No	6	8
10	3x37	4x57	alpha_off	23.425	0	Yes	No	Yes	No	7	8
11	2x45	4x46	alpha_off	37.2659	1.44441	No	No	No	No	9	8
12	2x42	4x46	alpha_off	29.7536	0	Yes	Yes	No	No	8	8
13	6x48	6x51	alpha_off	50.7313	0	Yes	Yes	Yes	Yes	8	7
14	3x39	6x44	alpha_off	81.5833	0	No	No	Yes	Yes	9	9
15	6x51	Lig	alpha_off	45.1369	2.18786	Yes	Yes	Yes	Yes	7	0
16	6x48	6x52	alpha_off	50.1679	4.41395	Yes	Yes	Yes	Yes	8	7
17	3x28	Lig	alpha_off	25.3031	0	Yes	Yes	Yes	Yes	5	0
18	E2	Lig	alpha_off	48.6825	0	Yes	Yes	Yes	Yes	4	0
19	3x40	6x44	alpha_off	35.6155	0	No	No	Yes	Yes	8	9
20	3x40	5x50	alpha_off	34.1415	6.06228	No	No	No	No	8	9
21	3x41	4x53	alpha_off	27.7901	0	No	No	No	No	6	8
22	3x43	6x41	alpha_off	67.3098	0	No	Yes	Yes	No	8	8
23	5x58	6x41	alpha_off	64.5438	4.43519	Yes	Yes	Yes	No	9	8
24	3x51	5x61	alpha_off	28.0804	0	Yes	No	No	No	8	9
25	4x57	4x58	alpha_off	12.2588	1.44441	Yes	No	No	No	8	4
26	6x40	7x49	alpha_off	16.4874	0	No	No	Yes	Yes	8	9
27	6x40	7x52	alpha_off	14.302	0	No	No	No	No	8	8
28	7x34	Lig	alpha_off	33.4016	0	No	No	Yes	Yes	4	0
29	7x34	E3	alpha_off	31.7967	0	No	No	Yes	Yes	4	3
30	6x54	E3	alpha_off	17.2842	0	No	No	Yes	Yes	5	3
31	6x54	7x37	alpha_off	14.8483	1.58885	No	No	No	No	5	5
32	8x50	8x54	alpha_off	20.9891	0	Yes	Yes	Yes	No	8	7
33	5x58	I3	alpha_off	15.5142	0	Yes	Yes	Yes	No	9	3
34	5x64	5x68	alpha_off	13.4198	0	No	No	No	No	6	7
35	8x48	8x49	alpha_off	11.4165	9.9282	No	No	No	No	5	7
36	1x34	NT	alpha_off	14.3646	0	Yes	No	Yes	No	4	0
37	E2	NT	alpha_off	16.0776	0	Yes	Yes	Yes	No	4	0
38	2x50	3x39	alpha_off	79.0905	2.12413	Yes	Yes	No	No	9	9
39	3x41	5x50	alpha_off	28.1999	0	No	No	No	No	6	9
40	7x39	7x42	Shared	21.5412	21.1564	Yes	No	Yes	Yes	6	7
41	2x56	3x32	Shared	36.2245	21.1861	No	Yes	No	No	8	7
42	2x50	7x46	Shared	38.8766	10.5527	Yes	Yes	No	No	9	9
43	1x50	2x50	Shared	24.2843	31.0294	Yes	Yes	Yes	Yes	9	9
44	2x50	7x49	Shared	77.793	29.6232	Yes	Yes	Yes	Yes	9	9
45	7x42	Lig	Shared	20.3119	65.8779	Yes	Yes	Yes	Yes	7	0
46	3x37	4x53	Shared	23.8347	16.8189	Yes	No	No	No	7	8
47	3x38	4x53	Shared	43.2132	15.4637	No	No	No	No	8	8
48	3x38	4x50	Shared	42.0466	14.1	No	No	No	No	8	9
49	2x45	4x50	Shared	40.8685	11.3471	No	No	No	No	9	9
50	2x42	3x49	Shared	16.7207	12.2817	Yes	Yes	Yes	Yes	8	9
51	6x44	6x48	Shared	100	83.0961	Yes	Yes	Yes	Yes	9	8
52	6x52	Lig	Shared	50.7882	14.2232	Yes	Yes	Yes	Yes	7	0
53	3x28	E1x50	Shared	14.0857	40.9746	Yes	Yes	Yes	Yes	5	8
54	3x43	6x44	Shared	74.5945	38.2174	No	Yes	Yes	Yes	8	9
55	5x58	5x61	Shared	45.4613	12.8	Yes	Yes	No	No	9	9
56	3x51	3x55	Shared	14.0174	93.3897	Yes	No	No	No	8	7
57	3x55	3x56	Shared	11.9629	92.574	No	No	No	Yes	7	6
58	5x47	6x52	Shared	14.1312	17.0016	Yes	Yes	Yes	Yes	8	7
59	8x47	8x50	Shared	21.3761	17.0483	No	No	Yes	Yes	8	8
60	8x47	8x49	Shared	19.8509	15.1663	No	No	No	No	8	7
61	3x54	5x61	Shared	16.9199	11.3046	No	No	No	No	8	9
62	3x54	5x64	Shared	15.4573	10.0557	No	No	No	No	8	6
63	1x52	8x54	Shared	15.8329	10.4083	Yes	No	Yes	No	7	7
64	3x32	Lig	Shared	30.1747	21.8446	No	No	Yes	Yes	7	0
65	1x39	7x39	alpha_on	9.52137	14.4229	No	No	Yes	No	7	6
66	2x57	7x42	alpha_on	9.00916	10.3233	No	No	Yes	Yes	8	7
67	6x48	Lig	alpha_on	0	92.9309	Yes	Yes	Yes	Yes	8	0
68	6x48	7x45	alpha_on	0	19.3806	Yes	Yes	No	No	8	9
69	7x45	7x49	alpha_on	0	16.2326	No	No	Yes	Yes	9	9
70	1x46	1x50	alpha_on	0	10.5527	Yes	No	Yes	Yes	8	9
71	5x54	6x44	alpha_on	0	100	No	No	Yes	Yes	8	9
72	3x47	5x54	alpha_on	0	99.7536	No	No	No	No	9	8
73	3x47	5x57	alpha_on	2.11712	98.135	No	No	No	No	9	6
74	3x51	5x57	alpha_on	4.22856	97.2174	Yes	No	No	No	8	6
75	3x52	3x56	alpha_on	0	88.3682	No	Yes	No	Yes	5	6
76	3x52	I2x53	alpha_on	3.07894	85.6748	No	Yes	Yes	Yes	5	7
77	3x49	I2x53	alpha_on	7.12538	45.431	Yes	Yes	Yes	Yes	9	7
78	2x39	3x49	alpha_on	1.08133	34.1136	No	No	Yes	Yes	8	9
79	2x37	2x39	alpha_on	0	65.3596	No	No	No	No	7	8
80	2x37	2x40	alpha_on	2.2594	62.9169	No	No	No	No	7	8
81	2x40	I1x50	alpha_on	0	19.8649	No	No	No	Yes	8	8
82	I2x53	I2x57	alpha_on	0.0739855	33.8545	Yes	Yes	Yes	No	7	6
83	2x39	I2x57	alpha_on	0.0512208	33.0048	No	No	Yes	No	8	6
84	5x461	Lig	alpha_on	0	22.1547	No	No	Yes	Yes	6	0
85	3x37	5x461	alpha_on	1.5537	20.8335	Yes	No	No	No	7	6
86	2x46	3x43	alpha_on	0	16.4875	No	No	No	Yes	9	8
87	2x56	7x42	alpha_on	0	23.3272	No	Yes	Yes	Yes	8	7
88	2x56	3x28	alpha_on	0	38.3619	No	Yes	Yes	Yes	8	5
89	2x59	3x28	alpha_on	9.79455	11.8824	No	No	Yes	Yes	5	5
90	2x60	7x42	alpha_on	2.62933	21.0289	No	No	Yes	Yes	7	7
91	2x60	3x28	alpha_on	1.94639	20.2345	No	No	Yes	Yes	7	5
92	E1x49	E1x50	alpha_on	0	17.4774	No	No	Yes	Yes	4	8
93	2x66	E1x49	alpha_on	5.02533	10.5102	No	No	No	No	5	4
94	5x43	Lig	alpha_on	0	19.5505	No	No	Yes	Yes	7	0
95	5x39	5x43	alpha_on	2.49843	18.6244	No	Yes	No	No	8	7
96	5x39	E2	alpha_on	6.7213	13.1866	No	Yes	Yes	Yes	8	4
97	3x43	7x53	alpha_on	0	21.5557	No	Yes	Yes	Yes	8	9
98	3x47	5x58	alpha_on	0	28.8457	No	No	Yes	Yes	9	9
99	5x47	6x49	alpha_on	3.21553	22.4096	Yes	Yes	No	Yes	8	7
100	7x52	7x53	alpha_on	0	11.9759	No	No	Yes	Yes	8	9
101	6x43	7x52	alpha_on	4.51312	10.4805	No	No	No	No	7	8
102	6x49	6x53	alpha_on	1.61061	10.8161	No	Yes	No	No	7	6
103	2x40	8x50	alpha_on	0	40.5412	No	No	Yes	Yes	8	8
104	3x50	7x53	alpha_on	0	16.4408	Yes	Yes	Yes	Yes	9	9
105	3x50	7x56	alpha_on	0	10.0132	Yes	Yes	No	No	9	7
106	7x54	8x50	alpha_on	0	19.9839	No	No	Yes	Yes	7	8
107	7x54	8x54	alpha_on	2.16835	16.1647	No	No	Yes	No	7	7
108	3x24	E1x52	alpha_on	0	11.9376	No	No	No	No	5	5
109	2x46	2x50	alpha_on	0	15.23	No	No	Yes	Yes	9	9
110	3x43	7x49	alpha_on	0	16.3601	No	Yes	Yes	Yes	8	9
111	3x50	5x58	alpha_on	0	12.7958	Yes	Yes	Yes	Yes	9	9
112	5x47	6x44	alpha_on	0	18.2718	Yes	Yes	Yes	Yes	8	9

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
2x56	3x32	Shared	5.6575	8.98917	0	1	2	1
2x57	7x42	Shared	6.22625	7.09625	0	0	2	1
2x59	3x28	Shared	9.86625	6.02208	0	0	2	1
2x60	3x28	Shared	5.6525	4.33125	0	0	2	1
3x28	E1x50	Shared	4.535	4.0575	1	0	1	2
3x22	E2	Shared	6.14	3.9825	0	0	2	1
3x28	Lig	alpha_off	9.93875	0	1	0	1	0
3x32	7x42	Shared	7.185	8.09417	1	1	1	1
3x32	Lig	Shared	19.4513	11.0379	1	1	1	0
3x33	4x57	Shared	4.645	3.02833	1	0	1	2
3x33	Lig	Shared	7.8025	10.8146	1	0	1	0
3x36	6x48	Shared	7.34625	5.00417	0	1	1	1
3x37	4x57	alpha_off	3.8	0	0	0	2	2
3x37	5x461	Shared	7.995	6.59417	0	0	2	1
3x40	6x44	alpha_off	5.27625	0	0	0	2	2
E2	E2	Shared	24.925	23.2017	1	2	1	1
5x36	E2	Shared	9.08625	3.45458	1	2	2	1
5x39	E2	Shared	7.60125	7.07375	1	2	2	1
5x39	5x43	Shared	10.4925	7.68458	1	2	2	1
5x40	6x55	Shared	8.3625	6.8275	0	0	2	1
5x44	6x52	Shared	3.7775	3.13125	0	0	2	1
5x47	6x52	Shared	22.1038	18.1267	0	1	2	1
6x44	6x48	Shared	9.84375	4.55167	0	1	2	1
6x48	6x51	alpha_off	5.63875	0	1	1	1	1
6x48	6x52	Shared	5.26	6.4725	1	1	1	1
6x48	7x41	Shared	11.4375	8.49958	1	1	1	2
6x51	6x52	Shared	10.0487	5.27	1	1	1	1
6x51	6x55	Shared	5.20625	6.5	1	1	1	1
6x51	7x38	Shared	7.39	5.49208	1	1	1	1
6x51	Lig	Shared	11.7738	16.9788	1	1	1	0
6x52	Lig	Shared	5.8575	5.95125	1	1	1	0
E3	E3	Shared	5.905	6.6275	1	6	2	2
7x34	Lig	alpha_off	4.36	0	1	0	1	0
7x38	7x42	Shared	4.75875	8.12167	1	1	1	1
7x38	Lig	Shared	14.3787	15.5125	1	1	1	0
7x39	7x42	Shared	5.0625	6.955	0	0	2	1
7x42	Lig	Shared	4.6875	8.55708	1	1	1	0
E2	Lig	alpha_off	6.2325	0	1	2	1	0
E2x51	Lig	alpha_off	4.69375	0	1	0	1	0
E2x52	Lig	alpha_off	8.96	0	1	0	1	0
E1x49	E2	alpha_off	6.47125	0	1	0	2	1
E2	E2x51	Shared	3.92	6.10333	1	2	1	1
6x44	7x45	alpha_off	8.11	0	0	1	2	2
7x34	E3	alpha_off	5.50875	0	1	0	1	2
NT	NT	alpha_off	3.985	0	1	0	2	2
2x60	7x42	Shared	3.815	5.92042	0	0	2	1
E2	NT	alpha_off	4.8675	0	1	2	1	2
3x26	E2	Shared	3.4225	1.35625	1	2	2	1
3x29	E2x52	alpha_off	3.38	0	0	0	2	1
4x62	E2	alpha_off	2.29375	0	1	0	2	1
3x21	E2	alpha_off	1.73875	0	0	0	2	1
2x56	3x28	alpha_on	0	5.45125	0	1	2	1
2x56	7x42	alpha_on	0	3.4325	0	1	2	1
3x36	Lig	alpha_on	0	8.54583	0	1	1	0
3x40	6x48	alpha_on	0	11.1079	0	0	2	1
4x60	E2	alpha_on	0	5.71833	0	2	2	1
4x60	5x39	alpha_on	0	10.0271	0	2	2	2
E2	E2x52	alpha_on	0	4.00333	1	2	1	1
5x43	Lig	alpha_on	0	4.95667	0	0	1	0
5x47	6x44	alpha_on	0	5.35917	0	1	2	2
6x48	7x45	alpha_on	0	9.8875	1	1	1	2
6x48	Lig	alpha_on	0	5.30042	1	1	1	0
6x55	Lig	alpha_on	0	4.62542	0	1	1	0
5x461	Lig	alpha_on	0	2.78375	0	0	1	0
6x51	7x34	alpha_on	0	2.67958	1	1	1	1
3x21	E1x50	alpha_on	0	1.75875	0	0	2	2
E1x49	E1x50	alpha_on	0	1.43583	1	0	2	2
3x28	3x29	alpha_on	0	1.41292	1	0	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	alpha_off	alpha1_off alpha2_off
	alpha_on	alpha1_on alpha2_on

Network Difference
Value	alpha_off	alpha_on
I_min	3.7675	3.42542
Number of Linked Nodes	271	264
Number of Specific Nodes	12 (4.43%)	5 (1.89%)
Number of Shared Nodes	259 (95.57%)	259 (98.11%)
Number of Links	294	287
Number of Specific Links	123 (41.84%)	116 (40.42%)
Number of Shared Links	171 (58.16%)	171 (59.58%)
Number of Hubs	37	28
Number of Specific Hubs	16 (43.24%)	7 (25.00%)
Number of Shared Hubs	21 (56.76%)	21 (75.00%)
Average % Shared Neighbours (Jaccard)	46.30
Average % Shared Neighbours (Otsuka)	55.08
Average % Shared Neighbours (Overlap Coefficient)	63.97
Average % Shared Cliques (k3-6)	81.25
Graphlets Similarity	0.556245

Paths Difference
Value	alpha_off	alpha_on
Number Of Nodes in MetaPath	62	68
Specific Nodes in MetaPath	23 (37.10%)	29 (42.65%)
Shared Nodes in MetaPath	259 (95.57%)	259 (95.57%)
Number Of Links MetaPath	64	73
Specific Links in MetaPath	39 (60.94%)	48 (65.75%)
Shared Links in MetaPath	171 (58.16%)	171 (58.16%)
Number of Shortest Paths	45683	53091
Length Of Smallest Path	3	3
Average Path Length	12.0199	14.2319
Length of Longest Path	26	32
Minimum Path Strength	0.62	0.269375
Average Path Strength	5.70381	5.3275
Maximum Path Strength	16.0763	14.0083
Minimum Path Correlation	0.7025	0.70125
Average Path Correlation	0.907073	0.885863
Maximum Path Correlation	0.98875	0.984583
Minimum % Of Corr. Nodes	4.16667	3.7037
Average % Of Corr. Nodes	44.7038	35.0043
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	47.4499	42.5287
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download alpha_off_on.zip<

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