psnGPCR

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Orange: nodes, hubs and links specific of angiotensin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of angiotensin_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Strength: the interaction strength between the two nodes or 0 if the link is not present.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	angiotensin_off Int. Strength	angiotensin_on Int. Strength	angiotensin_off Hub1?	angiotensin_on Hub1?	angiotensin_off Hub2?	angiotensin_on Hub2?	ConSurf1	ConSurf2
1	2x67	NT	angiotensin_off	17.135	0	No	No	Yes	Yes	3	4
2	1x35	2x64	angiotensin_off	14.455	0	Yes	Yes	Yes	No	6	5
3	1x39	Lig	angiotensin_off	7.4925	0	Yes	Yes	Yes	Yes	7	0
4	1x42	7x39	angiotensin_off	3.98	0	No	No	No	No	7	5
5	1x42	7x43	angiotensin_off	7.1225	0	No	No	No	No	7	5
6	1x42	7x47	angiotensin_off	4.4975	0	No	No	No	No	7	8
7	1x43	1x44	angiotensin_off	3.6025	0	No	No	No	No	6	5
8	1x53	7x53	angiotensin_off	5.9925	0	No	Yes	Yes	Yes	9	9
9	2x38	3x49	angiotensin_off	4.745	0	Yes	No	No	No	7	8
10	2x42	4x46	angiotensin_off	3.705	0	Yes	Yes	Yes	No	7	7
11	2x43	7x53	angiotensin_off	5.02	0	No	No	Yes	Yes	8	9
12	2x53	3x32	angiotensin_off	3.965	0	Yes	No	Yes	No	6	6
13	2x53	7x42	angiotensin_off	9.045	0	Yes	No	Yes	No	6	7
14	2x53	7x46	angiotensin_off	9.9525	0	Yes	No	Yes	No	6	9
15	2x59	3x28	angiotensin_off	3.835	0	No	No	No	No	6	6
16	2x60	E1x50	angiotensin_off	7.5	0	Yes	Yes	Yes	Yes	7	9
17	2x60	3x32	angiotensin_off	4.6425	0	Yes	Yes	Yes	No	7	6
18	3x26	E2	angiotensin_off	5.9125	0	No	No	Yes	Yes	6	4
19	3x30	4x61	angiotensin_off	4.095	0	No	No	No	No	5	4
20	3x35	7x42	angiotensin_off	3.4875	0	Yes	No	Yes	No	8	7
21	3x35	7x46	angiotensin_off	6.13	0	Yes	No	Yes	No	8	9
22	3x41	4x49	angiotensin_off	4.135	0	No	No	No	No	5	7
23	3x43	6x44	angiotensin_off	3.98	0	No	No	No	No	8	9
24	3x44	5x54	angiotensin_off	4.56	0	No	No	No	No	7	8
25	3x46	6x37	angiotensin_off	4.995	0	Yes	No	No	No	9	7
26	3x51	5x57	angiotensin_off	4.9175	0	Yes	Yes	No	No	8	7
27	4x48	4x52	angiotensin_off	4.605	0	No	No	No	No	3	4
28	4x63	4x64	angiotensin_off	10.315	0	No	No	Yes	No	4	4
29	4x64	E2x52	angiotensin_off	9.22	0	Yes	No	No	Yes	4	4
30	4x64	E2	angiotensin_off	9.29	0	Yes	No	Yes	Yes	4	4
31	4x65	Lig	angiotensin_off	18.89	0	No	No	Yes	Yes	5	0
32	5x35	E2	angiotensin_off	12.1325	0	No	No	Yes	Yes	1	4
33	5x49	5x53	angiotensin_off	3.4525	0	No	No	No	No	6	7
34	5x58	6x38	angiotensin_off	3.8675	0	Yes	Yes	No	No	9	4
35	5x61	6x34	angiotensin_off	4.3975	0	No	No	No	Yes	8	6
36	6x30	6x31	angiotensin_off	4.735	0	No	No	No	No	6	4
37	6x32	8x49	angiotensin_off	3.935	0	No	No	No	No	7	6
38	6x35	7x55	angiotensin_off	5.2725	0	No	No	No	No	5	6
39	6x40	7x49	angiotensin_off	4.25	0	No	No	Yes	No	8	9
40	6x40	7x52	angiotensin_off	4.865	0	No	No	Yes	No	8	8
41	6x44	7x45	angiotensin_off	4.5325	0	No	No	Yes	No	9	9
42	6x48	7x41	angiotensin_off	9.0825	0	Yes	Yes	No	No	8	8
43	6x48	7x42	angiotensin_off	3.6175	0	Yes	Yes	Yes	No	8	7
44	6x54	7x30	angiotensin_off	4.165	0	No	No	Yes	No	5	4
45	6x58	6x62	angiotensin_off	8.48	0	No	No	Yes	No	4	3
46	7x23	7x26	angiotensin_off	9.1775	0	No	No	No	No	4	1
47	7x42	Lig	angiotensin_off	4.845	0	Yes	No	Yes	Yes	7	0
48	7x45	7x46	angiotensin_off	4.0875	0	Yes	No	Yes	No	9	9
49	7x45	7x49	angiotensin_off	9.195	0	Yes	No	Yes	No	9	9
50	7x48	7x52	angiotensin_off	4.365	0	No	No	Yes	No	6	8
51	8x57	8x58	angiotensin_off	4.9725	0	No	No	No	No	4	6
52	1x36	2x64	angiotensin_off	3.655	0	No	No	Yes	No	5	5
53	3x26	4x62	angiotensin_off	4.0825	0	No	No	No	No	6	5
54	E2	E2x51	angiotensin_off	4.55	0	Yes	Yes	No	No	4	5
55	5x47	5x51	angiotensin_off	4.7025	0	No	Yes	No	No	8	6
56	7x54	7x55	angiotensin_off	4.0075	0	Yes	No	No	No	7	6
57	2x64	NT	angiotensin_off	8.25	0	Yes	No	Yes	Yes	5	4
58	1x53	7x54	angiotensin_off	4.44	0	No	Yes	Yes	No	9	7
59	1x57	7x54	angiotensin_off	6.745	0	No	No	Yes	No	7	7
60	1x60	I1	angiotensin_off	9.49	0	No	Yes	No	No	4	0
61	2x40	I1	angiotensin_off	5.355	0	Yes	No	No	No	8	0
62	8x51	I1	angiotensin_off	4.07	0	No	No	No	No	8	0
63	2x38	I2x56	angiotensin_off	7.19	0	Yes	No	No	No	7	4
64	2x52	3x31	angiotensin_off	4.87	0	No	No	No	No	7	5
65	2x53	3x36	angiotensin_off	3.535	0	Yes	No	No	No	6	7
66	3x24	3x28	angiotensin_off	6.22	0	No	No	No	No	5	6
67	3x31	3x35	angiotensin_off	5.435	0	No	No	Yes	No	5	8
68	3x42	4x50	angiotensin_off	3.51	0	No	No	Yes	Yes	7	9
69	3x43	7x49	angiotensin_off	4.25	0	No	No	Yes	No	8	9
70	3x46	7x53	angiotensin_off	5.985	0	Yes	No	Yes	Yes	9	9
71	3x50	8x50	angiotensin_off	11.225	0	No	No	Yes	Yes	9	8
72	3x56	I2x55	angiotensin_off	11.32	0	No	No	No	No	6	4
73	8x58	I2x50	angiotensin_off	7.225	0	No	No	No	No	6	8
74	4x38	4x39	angiotensin_off	4.075	0	Yes	No	No	No	7	1
75	5x32	E2	angiotensin_off	5.675	0	No	No	Yes	Yes	0	4
76	5x36	6x62	angiotensin_off	8.65	0	No	No	Yes	No	3	3
77	5x58	5x59	angiotensin_off	6.19	0	Yes	Yes	No	No	9	3
78	6x26	8x57	angiotensin_off	3.695	0	No	No	No	No	0	4
79	6x27	6x28	angiotensin_off	4.385	0	No	No	No	No	0	0
80	6x27	6x31	angiotensin_off	4.765	0	No	No	No	No	0	4
81	6x32	8x53	angiotensin_off	7.46	0	No	No	No	Yes	7	5
82	6x48	Lig	angiotensin_off	3.465	0	Yes	Yes	Yes	Yes	8	0
83	6x51	6x52	angiotensin_off	5.09	0	Yes	Yes	No	No	6	8
84	7x51	7x55	angiotensin_off	5.895	0	No	No	No	No	6	6
85	8x52	8x55	angiotensin_off	4.675	0	No	No	No	No	5	3
86	5x31	5x34	angiotensin_off	3.39	0	No	No	No	No	0	0
87	2x39	3x49	angiotensin_off	3.3675	0	No	No	No	No	7	8
88	2x54	7x46	angiotensin_off	3.28	0	No	No	Yes	No	6	9
89	3x49	3x50	angiotensin_off	3.275	0	No	No	No	No	8	9
90	6x63	E3	angiotensin_off	3.2575	0	No	No	Yes	No	1	1
91	3x48	3x52	angiotensin_off	3.22	0	No	No	No	No	6	5
92	3x54	5x64	angiotensin_off	3.175	0	No	No	No	No	8	5
93	1x54	2x44	angiotensin_off	3.1725	0	No	No	Yes	No	7	5
94	1x57	2x40	angiotensin_off	3.1425	0	No	No	Yes	No	7	8
95	6x36	8x50	angiotensin_off	3.11	0	No	No	Yes	Yes	8	8
96	1x50	2x51	angiotensin_off	3.09	0	No	No	No	No	9	7
97	5x65	6x31	angiotensin_off	3.0525	0	No	No	No	No	8	4
98	6x26	I3	angiotensin_off	3.005	0	No	No	No	Yes	0	0
99	1x34	7x36	angiotensin_off	2.915	0	No	No	No	No	4	6
100	7x30	7x31	angiotensin_off	2.86	0	Yes	No	No	No	4	4
101	1x40	2x58	angiotensin_off	2.78	0	No	No	No	No	5	9
102	6x58	7x34	angiotensin_off	2.7725	0	No	No	No	No	4	4
103	5x44	5x48	angiotensin_off	2.745	0	Yes	No	No	No	4	4
104	1x40	2x61	angiotensin_off	2.67	0	No	No	No	No	5	7
105	1x56	1x60	angiotensin_off	2.625	0	No	No	No	Yes	7	4
106	3x27	3x28	angiotensin_off	2.62	0	No	No	No	No	6	6
107	5x39	5x42	angiotensin_off	2.5725	0	No	No	No	No	5	3
108	2x38	4x42	angiotensin_off	2.545	0	Yes	No	No	No	7	7
109	7x27	7x31	angiotensin_off	2.485	0	No	No	No	No	3	4
110	8x50	8x54	angiotensin_off	2.435	0	Yes	Yes	No	No	8	7
111	4x55	4x59	angiotensin_off	2.42	0	No	No	No	No	4	4
112	5x35	5x39	angiotensin_off	2.35	0	No	No	No	No	1	5
113	5x37	6x63	angiotensin_off	2.2325	0	No	No	No	No	2	1
114	7x25	7x29	angiotensin_off	2.1925	0	No	No	No	No	2	1
115	3x50	3x53	angiotensin_off	2.075	0	No	No	No	No	9	8
116	4x51	4x55	angiotensin_off	2.075	0	No	No	No	No	4	4
117	3x52	I2x52	angiotensin_off	1.995	0	No	No	No	No	5	4
118	6x33	8x50	angiotensin_off	1.965	0	No	No	Yes	Yes	7	8
119	6x36	8x49	angiotensin_off	1.86	0	No	No	No	No	8	6
120	5x37	5x38	angiotensin_off	1.8575	0	No	No	No	No	2	4
121	8x54	8x58	angiotensin_off	1.825	0	No	No	No	No	7	6
122	5x66	5x67	angiotensin_off	1.795	0	No	No	No	No	5	4
123	2x49	3x38	angiotensin_off	1.79	0	No	No	No	No	8	7
124	4x46	4x47	angiotensin_off	1.765	0	Yes	No	No	No	7	4
125	1x58	I1x50	angiotensin_off	1.7575	0	No	No	No	No	4	7
126	5x60	5x63	angiotensin_off	1.745	0	No	No	No	No	3	3
127	5x41	5x44	angiotensin_off	1.715	0	No	No	Yes	No	4	4
128	5x46	5x461	angiotensin_off	1.71	0	No	No	No	No	4	5
129	1x45	7x47	angiotensin_off	1.675	0	No	No	No	No	5	8
130	4x60	5x42	angiotensin_off	1.675	0	No	No	No	No	6	3
131	4x38	I2x54	angiotensin_off	1.6175	0	Yes	No	Yes	No	7	4
132	7x32	NT	angiotensin_off	1.615	0	No	No	Yes	Yes	1	4
133	6x29	8x57	angiotensin_off	1.585	0	No	No	No	No	0	4
134	1x51	1x54	angiotensin_off	1.535	0	No	No	No	No	3	7
135	5x33	5x34	angiotensin_off	1.515	0	No	No	No	No	0	0
136	6x24	6x27	angiotensin_off	1.5	0	No	No	No	No	0	0
137	1x52	1x56	angiotensin_off	1.49	0	No	No	No	No	6	7
138	5x45	5x49	angiotensin_off	1.47	0	No	No	No	No	5	6
139	7x54	8x47	angiotensin_off	1.455	0	Yes	No	No	No	7	8
140	I2x53	I2x54	angiotensin_off	1.445	0	No	No	Yes	No	6	4
141	5x64	5x68	angiotensin_off	1.37	0	No	No	No	No	5	0
142	8x56	8x59	angiotensin_off	1.32	0	No	No	No	No	3	0
143	5x40	5x43	angiotensin_off	1.3075	0	No	No	No	Yes	5	5
144	5x33	6x62	angiotensin_off	1.295	0	No	No	Yes	No	0	3
145	1x33	NT	angiotensin_off	1.26	0	No	No	Yes	Yes	5	4
146	1x55	1x58	angiotensin_off	1.255	0	No	No	No	No	3	4
147	4x40	4x43	angiotensin_off	1.235	0	No	No	No	No	4	3
148	5x48	5x52	angiotensin_off	1.08	0	No	No	No	No	4	3
149	I1x51	I2x55	angiotensin_off	1.0575	0	No	No	No	No	7	4
150	1x47	2x55	angiotensin_off	1.0525	0	No	No	No	No	6	4
151	6x64	E3	angiotensin_off	0.85	0	No	No	Yes	No	2	1
152	I2x54	I2x57	angiotensin_off	0.8	0	Yes	No	No	Yes	4	6
153	3x23	3x27	angiotensin_off	0.8	0	No	No	No	No	1	6
154	6x29	8x56	angiotensin_off	0.8	0	No	No	No	No	0	3
155	5x52	5x56	angiotensin_off	0.76	0	No	No	No	No	3	4
156	8x48	8x49	angiotensin_off	0.7175	0	No	No	No	No	5	6
157	8x48	8x51	angiotensin_off	0.7175	0	No	No	No	No	5	8
158	1x44	1x48	angiotensin_off	0.655	0	No	No	No	No	5	4
159	NT	NT	Shared	10.4075	17	Yes	Yes	Yes	Yes	4	4
160	E2	NT	Shared	9.0975	74.91	Yes	Yes	Yes	Yes	4	4
161	7x24	NT	Shared	3.64	7.28	No	No	Yes	Yes	7	4
162	7x31	NT	Shared	3.845	6.31	No	No	Yes	Yes	4	4
163	E1	NT	Shared	4.3575	7.2	No	Yes	Yes	Yes	4	4
164	1x28	1x30	Shared	4.6275	10.89	No	Yes	No	No	4	6
165	1x28	7x28	Shared	5.3575	7.56	No	Yes	No	No	4	4
166	1x28	7x32	Shared	3.765	5.48	No	Yes	No	No	4	1
167	1x32	2x67	Shared	7.87	16.32	No	No	No	No	4	3
168	1x35	1x39	Shared	6.045	6.04	Yes	Yes	Yes	Yes	6	7
169	1x35	7x36	Shared	5.13	2.94	Yes	Yes	No	No	6	6
170	1x39	2x57	Shared	6.1525	8.21	Yes	Yes	No	Yes	7	8
171	1x39	7x39	Shared	8.5475	4.03	Yes	Yes	No	No	7	5
172	1x43	1x47	Shared	6.54	5.02	No	No	No	No	6	6
173	1x43	2x58	Shared	12.2775	14.45	No	No	No	No	6	9
174	1x47	2x51	Shared	5.94	2.85	No	No	No	No	6	7
175	1x49	7x50	Shared	5.565	2.03	No	No	No	No	7	9
176	1x50	2x50	Shared	8.0775	6.73	No	No	Yes	Yes	9	9
177	1x50	7x50	Shared	10.585	11.4	No	No	No	No	9	9
178	1x57	2x44	Shared	6.6075	4.28	No	No	Yes	No	7	5
179	2x42	3x45	Shared	10.315	4.19	Yes	Yes	No	No	7	7
180	2x42	3x46	Shared	4.8325	3.65	Yes	Yes	Yes	No	7	9
181	2x42	4x45	Shared	6.5	5.19	Yes	Yes	No	No	7	5
182	2x43	3x46	Shared	4.6075	2.77	No	No	Yes	No	8	9
183	2x45	3x42	Shared	8.02	4.12	No	No	No	No	9	7
184	2x45	4x46	Shared	8.465	7.87	No	No	Yes	No	9	7
185	2x45	4x50	Shared	5.085	6.78	No	No	Yes	Yes	9	9
186	2x46	2x50	Shared	6.445	4.07	No	Yes	Yes	Yes	9	9
187	2x46	7x49	Shared	6.8625	4.12	No	Yes	Yes	No	9	9
188	2x50	7x46	Shared	11.2125	4.63	Yes	Yes	Yes	No	9	9
189	2x50	7x49	Shared	6.395	6.73	Yes	Yes	Yes	No	9	9
190	2x53	3x35	Shared	8.02	1.56	Yes	No	Yes	No	6	8
191	2x56	3x31	Shared	4.6475	6.4	No	No	No	No	7	5
192	2x59	E1x52	Shared	9.44	4.87	No	No	Yes	Yes	6	6
193	2x60	Lig	Shared	20.705	16.21	Yes	Yes	Yes	Yes	7	0
194	2x62	E1x52	Shared	4.2325	2.62	No	No	Yes	Yes	4	6
195	2x63	E1	Shared	9.18	10.92	No	Yes	No	Yes	5	4
196	2x63	E1x50	Shared	8.925	10.61	No	Yes	Yes	Yes	5	9
197	2x63	Lig	Shared	3.4475	4.84	No	Yes	Yes	Yes	5	0
198	2x64	E1	Shared	5.79	7.49	Yes	No	No	Yes	5	4
199	2x66	E1x51	Shared	5.61	3.35	No	No	No	No	5	3
200	E1x49	E2	Shared	14.3375	5.01	No	No	Yes	Yes	5	4
201	E1x50	E1x52	Shared	13.0275	17.04	Yes	Yes	Yes	Yes	9	6
202	3x25	E1x50	Shared	5.55	9.14	No	No	Yes	Yes	9	9
203	E1x50	E2x50	Shared	9.47	15.67	Yes	Yes	No	No	9	9
204	E1x51	E1x52	Shared	6.5	7.22	No	No	Yes	Yes	3	6
205	3x24	E1x52	Shared	5.86	6.09	No	No	Yes	Yes	5	6
206	3x22	E2	Shared	9.925	12.72	No	No	Yes	Yes	3	4
207	3x25	E2x50	Shared	7.28	7.28	No	No	No	No	9	9
208	3x29	4x65	Shared	7.6675	15.81	No	No	No	No	5	5
209	3x30	4x62	Shared	4.93	4.87	No	No	No	No	5	5
210	3x32	7x42	Shared	4.96	3.79	Yes	No	Yes	No	6	7
211	3x32	Lig	Shared	13.51	3.93	Yes	No	Yes	Yes	6	0
212	3x33	Lig	Shared	9.85	5.28	No	No	Yes	Yes	4	0
213	3x34	4x50	Shared	6.15	7.02	No	Yes	Yes	Yes	5	9
214	3x34	4x53	Shared	3.91	2.77	No	Yes	No	No	5	8
215	3x36	6x48	Shared	10.905	3.42	No	No	Yes	Yes	7	8
216	3x36	Lig	Shared	6.0525	4.87	No	No	Yes	Yes	7	0
217	3x37	3x41	Shared	6.63	6.19	No	Yes	No	No	7	5
218	3x37	4x56	Shared	9.955	8.01	No	Yes	No	No	7	5
219	3x37	Lig	Shared	5.545	4.13	No	Yes	Yes	Yes	7	0
220	3x40	5x50	Shared	3.46	3.53	No	No	No	Yes	8	8
221	3x42	4x49	Shared	10.66	2.85	No	No	No	No	7	7
222	3x44	5x53	Shared	4.385	6.08	No	No	No	No	7	7
223	3x47	5x54	Shared	8.9025	4.64	No	No	No	No	9	8
224	3x47	5x58	Shared	5.725	5.09	No	No	Yes	Yes	9	9
225	3x51	3x55	Shared	11.725	11.36	Yes	Yes	No	No	8	7
226	3x51	3x56	Shared	3.54	8.71	Yes	Yes	No	No	8	6
227	3x51	5x60	Shared	4.8125	8.21	Yes	Yes	No	No	8	3
228	3x54	5x61	Shared	9.7275	4.42	No	No	No	No	8	8
229	3x55	3x56	Shared	10.455	11.07	No	No	No	No	7	6
230	I2x51	I2x54	Shared	4.445	1.24	No	No	Yes	No	6	4
231	4x65	E2x52	Shared	7.19	17.1	No	No	No	Yes	5	4
232	E2	E2	Shared	53.735	65.49	Yes	Yes	Yes	Yes	4	4
233	E2	E2x52	Shared	11.4225	4.13	Yes	Yes	No	Yes	4	4
234	6x62	E2	Shared	4.7925	18.18	Yes	No	Yes	Yes	3	4
235	5x47	6x52	Shared	15.22	10.54	No	Yes	No	No	8	8
236	5x49	5x50	Shared	3.86	1.44	No	No	No	Yes	6	8
237	5x51	6x45	Shared	13.215	9.65	No	No	No	Yes	6	5
238	5x58	6x37	Shared	3.4525	3.63	Yes	Yes	No	No	9	7
239	5x58	6x41	Shared	6.3075	5.05	Yes	Yes	No	No	9	8
240	5x62	5x66	Shared	5.01	3.48	No	Yes	No	No	5	5
241	6x39	7x52	Shared	4.95	2.77	No	No	Yes	No	5	8
242	6x40	7x53	Shared	5.3475	8.46	No	No	Yes	Yes	8	9
243	6x43	6x47	Shared	3.6325	3.96	No	Yes	No	No	6	8
244	6x43	7x48	Shared	5.4175	7.31	No	Yes	No	No	6	6
245	6x43	7x52	Shared	4.51	11.79	No	Yes	Yes	No	6	8
246	6x44	6x48	Shared	7.5175	5.01	No	No	Yes	Yes	9	8
247	6x51	6x55	Shared	7.9275	6.85	Yes	Yes	No	No	6	6
248	6x51	7x37	Shared	5.1425	8.21	Yes	Yes	No	No	6	7
249	6x51	7x38	Shared	5.895	3.98	Yes	Yes	No	No	6	6
250	6x54	7x33	Shared	4.6025	8.32	No	No	No	No	5	5
251	6x56	6x60	Shared	7.915	6.09	No	No	No	No	5	3
252	6x57	7x30	Shared	4.7475	2.98	No	No	Yes	No	5	4
253	6x60	E3	Shared	9.045	9.99	No	No	Yes	No	3	1
254	7x26	E3	Shared	4.48	4.42	No	No	Yes	No	1	1
255	7x38	Lig	Shared	7.615	6.41	No	No	Yes	Yes	6	0
256	2x56	2x60	Shared	4.8525	4.85	No	No	Yes	Yes	7	7
257	3x33	4x61	Shared	4.3525	3.42	No	No	No	No	4	4
258	5x44	6x52	Shared	7.435	3.96	Yes	No	No	No	4	8
259	2x52	3x35	Shared	6.18	6.3	No	No	Yes	No	7	8
260	2x57	7x42	Shared	8.525	8.21	No	Yes	Yes	No	8	7
261	4x64	5x35	Shared	4.01	2.57	Yes	No	No	No	4	1
262	5x43	Lig	Shared	4.29	24.77	No	Yes	Yes	Yes	5	0
263	I3	I3	Shared	6.395	4.06	No	Yes	No	Yes	0	0
264	6x47	7x45	Shared	3.935	8.94	No	No	Yes	No	8	9
265	6x51	Lig	Shared	5.93	7.92	Yes	Yes	Yes	Yes	6	0
266	1x35	7x35	Shared	3.39	5.08	Yes	Yes	No	No	6	5
267	3x47	5x57	Shared	3.35	4.89	No	No	No	No	9	7
268	3x55	5x64	Shared	3.315	5.09	No	No	No	No	7	5
269	2x50	3x39	Shared	3.3125	5.89	Yes	Yes	No	No	9	9
270	6x36	7x56	Shared	3.305	4.28	No	No	No	No	8	7
271	1x38	7x39	Shared	3.265	6.35	No	No	No	No	5	5
272	3x33	4x57	Shared	3.23	6.52	No	No	No	No	4	7
273	2x38	2x42	Shared	3.205	2.62	Yes	No	Yes	Yes	7	7
274	1x58	1x59	Shared	3.06	7.22	No	No	No	No	4	4
275	5x461	5x50	Shared	3.045	4.06	No	No	No	Yes	5	8
276	5x47	6x49	Shared	3.045	3.77	No	Yes	No	Yes	8	5
277	5x62	6x34	Shared	2.97	10.02	No	Yes	No	Yes	5	6
278	1x53	2x47	Shared	2.9675	1.7	No	Yes	No	No	9	8
279	2x44	2x48	Shared	2.965	2.77	Yes	No	No	No	5	5
280	6x49	6x53	Shared	2.96	4.42	No	Yes	No	No	5	6
281	6x45	6x46	Shared	2.945	10.72	No	Yes	No	No	5	6
282	1x46	7x47	Shared	2.94	1.96	No	Yes	No	No	8	8
283	3x21	E1x50	Shared	2.81	2.81	No	No	Yes	Yes	8	9
284	7x23	7x25	Shared	2.8025	4.76	No	No	No	No	4	2
285	3x48	5x53	Shared	2.78	2.94	No	No	No	No	6	7
286	1x36	2x65	Shared	2.76	3.74	No	No	No	No	5	3
287	1x30	1x31	Shared	2.72	7.25	No	No	No	No	6	3
288	2x40	I1x48	Shared	2.6825	7.67	Yes	No	No	No	8	5
289	5x65	6x34	Shared	2.605	4.87	No	No	No	Yes	8	6
290	3x38	4x50	Shared	2.595	6.48	No	No	Yes	Yes	7	9
291	6x49	6x50	Shared	2.515	5.08	No	Yes	No	No	5	9
292	3x41	4x52	Shared	2.4625	3.65	No	No	No	No	5	4
293	2x44	I1x50	Shared	2.4225	5.54	Yes	No	No	No	5	7
294	5x44	6x56	Shared	2.415	3.62	Yes	No	No	No	4	5
295	6x61	7x30	Shared	2.305	4.61	No	No	Yes	No	2	4
296	6x59	6x63	Shared	2.295	1.49	No	No	No	No	4	1
297	4x38	4x40	Shared	2.26	1.47	Yes	No	No	No	7	4
298	8x52	8x56	Shared	2.03	8.18	No	No	No	No	5	3
299	3x34	4x54	Shared	1.925	3.01	No	Yes	No	No	5	3
300	4x41	4x45	Shared	1.7675	1.59	No	No	No	No	4	5
301	4x59	4x60	Shared	1.64	3.28	No	No	No	No	4	6
302	6x50	7x40	Shared	1.64	5.08	No	No	No	No	9	8
303	2x41	4x46	Shared	1.625	1.71	No	Yes	Yes	No	6	7
304	1x41	1x45	Shared	1.505	1.54	No	No	No	No	5	5
305	1x37	1x41	Shared	1.47	1.52	No	No	No	No	6	5
306	4x38	4x41	Shared	1.4525	3.17	Yes	No	No	No	7	4
307	6x38	6x42	Shared	1.4125	2.83	No	No	No	No	4	5
308	2x37	2x40	Shared	1.2	4.8	No	No	Yes	No	8	8
309	4x44	4x48	Shared	0.77	3.07	No	No	No	No	3	3
310	5x55	5x59	Shared	0.7375	2.95	No	No	No	No	5	3
311	Lig	NT	angiotensin_on	0	16.77	Yes	Yes	Yes	Yes	0	4
312	1x28	1x31	angiotensin_on	0	5.3	No	Yes	No	No	4	3
313	1x32	E1	angiotensin_on	0	4.13	No	No	No	Yes	4	4
314	1x35	1x36	angiotensin_on	0	3.39	Yes	Yes	No	No	6	5
315	1x39	7x38	angiotensin_on	0	6.04	Yes	Yes	No	No	7	6
316	1x43	2x57	angiotensin_on	0	3.65	No	No	No	Yes	6	8
317	1x52	7x55	angiotensin_on	0	3.65	No	No	No	No	6	6
318	1x52	8x54	angiotensin_on	0	6.09	No	No	No	No	6	7
319	1x53	1x57	angiotensin_on	0	3.07	No	Yes	No	No	9	7
320	1x53	7x50	angiotensin_on	0	3.53	No	Yes	No	No	9	9
321	1x55	1x59	angiotensin_on	0	3.77	No	No	No	No	3	4
322	1x56	8x50	angiotensin_on	0	3.93	No	No	Yes	Yes	7	8
323	1x56	8x53	angiotensin_on	0	3.79	No	No	No	Yes	7	5
324	1x59	1x60	angiotensin_on	0	3.09	No	No	No	Yes	4	4
325	1x60	8x53	angiotensin_on	0	10.92	No	Yes	No	Yes	4	5
326	1x60	8x56	angiotensin_on	0	7.89	No	Yes	No	No	4	3
327	1x60	8x57	angiotensin_on	0	8.21	No	Yes	No	No	4	4
328	1x60	8x60	angiotensin_on	0	3.97	No	Yes	No	No	4	0
329	I1x49	I1x51	angiotensin_on	0	5.75	No	No	No	No	5	7
330	2x41	4x42	angiotensin_on	0	5.09	No	Yes	No	No	6	7
331	2x41	4x43	angiotensin_on	0	4.55	No	Yes	No	No	6	3
332	2x42	3x49	angiotensin_on	0	9.55	Yes	Yes	No	No	7	8
333	2x46	3x43	angiotensin_on	0	5.54	No	Yes	No	No	9	8
334	2x46	7x53	angiotensin_on	0	3.52	No	Yes	Yes	Yes	9	9
335	2x56	2x59	angiotensin_on	0	4.42	No	No	No	No	7	6
336	2x60	2x63	angiotensin_on	0	3.86	Yes	Yes	No	Yes	7	5
337	2x60	3x28	angiotensin_on	0	3.89	Yes	Yes	No	No	7	6
338	2x67	E1x49	angiotensin_on	0	10.47	No	No	No	No	3	5
339	E1	Lig	angiotensin_on	0	10.64	No	Yes	Yes	Yes	4	0
340	3x22	3x26	angiotensin_on	0	8.39	No	No	No	No	3	6
341	3x34	3x35	angiotensin_on	0	4.83	No	Yes	Yes	No	5	8
342	3x36	7x42	angiotensin_on	0	7.03	No	No	Yes	No	7	7
343	3x37	5x42	angiotensin_on	0	4.99	No	Yes	No	No	7	3
344	3x37	5x43	angiotensin_on	0	4.78	No	Yes	No	Yes	7	5
345	3x40	6x48	angiotensin_on	0	4.9	No	No	Yes	Yes	8	8
346	3x43	7x53	angiotensin_on	0	5.86	No	No	Yes	Yes	8	9
347	3x44	5x50	angiotensin_on	0	3.5	No	No	No	Yes	7	8
348	3x45	4x49	angiotensin_on	0	3.27	No	No	No	No	7	7
349	3x49	I2x57	angiotensin_on	0	10.72	No	No	No	Yes	8	6
350	3x50	5x58	angiotensin_on	0	8.23	No	No	Yes	Yes	9	9
351	3x50	7x53	angiotensin_on	0	7.2	No	No	Yes	Yes	9	9
352	3x51	3x52	angiotensin_on	0	3.52	Yes	Yes	No	No	8	5
353	3x51	5x61	angiotensin_on	0	3.63	Yes	Yes	No	No	8	8
354	3x52	I2x57	angiotensin_on	0	3.64	No	No	No	Yes	5	6
355	3x53	I2x57	angiotensin_on	0	5.53	No	No	No	Yes	8	6
356	I2x53	I2x57	angiotensin_on	0	6.59	No	No	No	Yes	6	6
357	4x64	5x36	angiotensin_on	0	4.58	Yes	No	No	No	4	3
358	E2	E2x50	angiotensin_on	0	5.12	Yes	Yes	No	No	4	9
359	E2	Lig	angiotensin_on	0	34.34	Yes	Yes	Yes	Yes	4	0
360	E2x51	Lig	angiotensin_on	0	4.95	No	No	Yes	Yes	5	0
361	5x39	E2x52	angiotensin_on	0	4.87	No	No	No	Yes	5	4
362	E2x52	Lig	angiotensin_on	0	6.19	No	Yes	Yes	Yes	4	0
363	5x36	E2	angiotensin_on	0	13.08	No	No	Yes	Yes	3	4
364	5x37	6x62	angiotensin_on	0	6.86	No	No	Yes	No	2	3
365	5x43	6x51	angiotensin_on	0	7.86	No	Yes	Yes	Yes	5	6
366	5x43	6x55	angiotensin_on	0	10.51	No	Yes	No	No	5	6
367	5x47	6x45	angiotensin_on	0	6.43	No	Yes	No	Yes	8	5
368	5x51	5x55	angiotensin_on	0	6.09	No	No	No	No	6	5
369	5x51	6x44	angiotensin_on	0	3.22	No	No	No	No	6	9
370	5x54	6x44	angiotensin_on	0	5.02	No	No	No	No	8	9
371	5x58	6x40	angiotensin_on	0	4.84	Yes	Yes	No	No	9	8
372	5x62	6x37	angiotensin_on	0	5.87	No	Yes	No	No	5	7
373	5x62	6x38	angiotensin_on	0	4.65	No	Yes	No	No	5	4
374	5x66	6x34	angiotensin_on	0	8.69	No	No	No	Yes	5	6
375	6x28	I3	angiotensin_on	0	5.56	No	No	No	Yes	0	0
376	6x30	I3	angiotensin_on	0	6.98	No	No	No	Yes	6	0
377	6x33	I3	angiotensin_on	0	4.84	No	No	No	Yes	7	0
378	6x29	I3	angiotensin_on	0	3.71	No	No	No	Yes	0	0
379	6x28	6x30	angiotensin_on	0	6.52	No	No	No	No	0	6
380	6x30	6x34	angiotensin_on	0	6.04	No	No	No	Yes	6	6
381	6x31	6x32	angiotensin_on	0	10.65	No	No	No	No	4	7
382	6x33	6x34	angiotensin_on	0	3.77	No	No	No	Yes	7	6
383	6x43	7x45	angiotensin_on	0	6.04	No	Yes	Yes	No	6	9
384	6x45	6x49	angiotensin_on	0	7.54	No	Yes	No	Yes	5	5
385	6x48	6x52	angiotensin_on	0	3.29	Yes	Yes	No	No	8	8
386	6x48	7x45	angiotensin_on	0	7.91	Yes	Yes	Yes	No	8	9
387	6x50	7x37	angiotensin_on	0	3.5	No	No	No	No	9	7
388	6x51	7x34	angiotensin_on	0	3.94	Yes	Yes	No	No	6	4
389	6x58	Lig	angiotensin_on	0	14.05	No	No	Yes	Yes	4	0
390	6x61	E3	angiotensin_on	0	5.89	No	No	Yes	No	2	1
391	6x61	Lig	angiotensin_on	0	5.01	No	No	Yes	Yes	2	0
392	7x24	7x27	angiotensin_on	0	3.61	No	No	No	No	7	3
393	7x26	7x29	angiotensin_on	0	4.42	No	No	No	No	1	1
394	7x28	7x32	angiotensin_on	0	4.34	No	No	No	No	4	1
395	7x31	Lig	angiotensin_on	0	22.07	No	No	Yes	Yes	4	0
396	7x34	Lig	angiotensin_on	0	13.98	No	No	Yes	Yes	4	0
397	7x35	Lig	angiotensin_on	0	7.63	No	No	Yes	Yes	5	0
398	7x40	7x43	angiotensin_on	0	5.02	No	No	No	No	8	5
399	7x49	7x53	angiotensin_on	0	3.49	Yes	No	Yes	Yes	9	9
400	7x55	8x50	angiotensin_on	0	5.36	No	No	Yes	Yes	6	8
401	8x49	8x53	angiotensin_on	0	9.55	No	No	No	Yes	6	5
402	8x50	8x53	angiotensin_on	0	4.13	Yes	Yes	No	Yes	8	5
403	8x52	8x53	angiotensin_on	0	11.32	No	No	No	Yes	5	5
404	8x53	8x56	angiotensin_on	0	4.51	No	Yes	No	No	5	3
405	Lig	Lig	angiotensin_on	0	30	Yes	Yes	Yes	Yes	0	0
406	7x54	8x50	angiotensin_on	0	3.01	Yes	No	Yes	Yes	7	8
407	2x40	I1x50	angiotensin_on	0	3	Yes	No	No	No	8	7
408	5x42	5x46	angiotensin_on	0	2.95	No	No	No	No	3	4
409	1x31	1x35	angiotensin_on	0	2.94	No	No	Yes	Yes	3	6
410	4x62	4x63	angiotensin_on	0	2.94	No	No	No	No	5	4
411	6x36	6x40	angiotensin_on	0	2.94	No	No	No	No	8	8
412	1x34	1x35	angiotensin_on	0	2.92	No	No	Yes	Yes	4	6
413	1x42	2x57	angiotensin_on	0	2.85	No	No	No	Yes	7	8
414	3x54	5x65	angiotensin_on	0	2.85	No	No	No	No	8	8
415	5x61	5x65	angiotensin_on	0	2.85	No	No	No	No	8	8
416	3x41	4x53	angiotensin_on	0	2.77	No	No	No	No	5	8
417	6x31	6x35	angiotensin_on	0	2.77	No	No	No	No	4	5
418	7x51	7x56	angiotensin_on	0	2.77	No	No	No	No	6	7
419	1x39	2x61	angiotensin_on	0	2.67	Yes	Yes	No	No	7	7
420	1x53	7x55	angiotensin_on	0	2.62	No	Yes	No	No	9	6
421	2x38	I2x57	angiotensin_on	0	2.62	Yes	No	No	Yes	7	6
422	2x49	4x50	angiotensin_on	0	2.59	No	No	Yes	Yes	8	9
423	6x54	7x37	angiotensin_on	0	2.59	No	No	No	No	5	7
424	7x25	7x26	angiotensin_on	0	2.51	No	No	No	No	2	1
425	5x47	5x48	angiotensin_on	0	2.44	No	Yes	No	No	8	4
426	5x62	5x63	angiotensin_on	0	2.32	No	Yes	No	No	5	3
427	1x45	1x46	angiotensin_on	0	1.84	No	No	No	Yes	5	8
428	5x40	6x59	angiotensin_on	0	1.84	No	No	No	No	5	4
429	1x46	2x54	angiotensin_on	0	1.71	No	Yes	No	No	8	6
430	3x30	4x57	angiotensin_on	0	1.71	No	No	No	No	5	7
431	5x39	5x40	angiotensin_on	0	1.71	No	No	No	No	5	5
432	1x46	1x50	angiotensin_on	0	1.7	No	Yes	No	No	8	9
433	1x54	2x47	angiotensin_on	0	1.7	No	No	No	No	7	8
434	2x37	2x39	angiotensin_on	0	1.68	No	No	No	No	8	7
435	4x60	5x39	angiotensin_on	0	1.64	No	No	No	No	6	5
436	1x40	1x41	angiotensin_on	0	1.55	No	No	No	No	5	5
437	1x47	1x51	angiotensin_on	0	1.55	No	No	No	No	6	3
438	3x56	I2x50	angiotensin_on	0	1.53	No	No	No	No	6	8
439	2x38	4x39	angiotensin_on	0	1.52	Yes	No	No	No	7	1
440	2x41	4x39	angiotensin_on	0	1.52	No	Yes	No	No	6	1
441	1x48	1x49	angiotensin_on	0	1.51	No	No	No	No	4	7
442	4x40	4x44	angiotensin_on	0	1.49	No	No	No	No	4	3
443	4x47	4x48	angiotensin_on	0	1.47	No	No	No	No	4	3
444	5x56	5x60	angiotensin_on	0	1.47	No	No	No	No	4	3
445	5x67	I3	angiotensin_on	0	1.45	No	No	No	Yes	4	0
446	8x55	8x59	angiotensin_on	0	1.41	No	No	No	No	3	0
447	8x55	8x58	angiotensin_on	0	1.38	No	No	No	No	3	6
448	5x68	I3	angiotensin_on	0	1.33	No	No	No	Yes	0	0
449	3x52	I2x56	angiotensin_on	0	1.21	No	No	No	No	5	4
450	I2x55	I2x56	angiotensin_on	0	1.21	No	No	No	No	4	4
451	6x29	6x31	angiotensin_on	0	1.19	No	No	No	No	0	4
452	8x59	8x60	angiotensin_on	0	1.19	No	No	No	No	0	0

Orange: nodes, hubs and links specific of angiotensin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of angiotensin_on network

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Owner: the name of the network the hub belong to or "Shared" if the corresponding hub is present in both networks.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub in the corresponding network.

Num Of Links: the number of links of the corresponding hub in the corresponding network.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Owner	angiotensin_off Avg Int. Strength	angiotensin_on Avg Int. Strength	angiotensin_off Num Of Links	angiotensin_on Num Of Links	ConSurf
1	2x38	angiotensin_off	4.42125	2.25333	4	3	7
2	2x40	angiotensin_off	3.095	5.15667	4	3	8
3	2x44	angiotensin_off	3.79187	4.19667	4	3	5
4	2x53	angiotensin_off	6.9035	1.56	5	1	6
5	2x64	angiotensin_off	8.0375	7.49	4	1	5
6	3x32	angiotensin_off	6.76937	3.86	4	2	6
7	3x35	angiotensin_off	5.8505	4.23	5	3	8
8	3x46	angiotensin_off	5.105	3.21	4	2	9
9	I2x54	angiotensin_off	2.07687	1.24	4	1	4
10	4x38	angiotensin_off	2.35125	2.32	4	2	7
11	4x46	angiotensin_off	3.89	4.79	4	2	7
12	4x64	angiotensin_off	8.20875	3.575	4	2	4
13	5x44	angiotensin_off	3.5775	3.79	4	2	4
14	6x62	angiotensin_off	5.80438	12.52	4	2	3
15	E3	angiotensin_off	4.40812	6.76667	4	3	1
16	7x30	angiotensin_off	3.51938	3.795	4	2	4
17	7x42	angiotensin_off	5.74667	6.34333	6	3	7
18	7x45	angiotensin_off	5.4375	7.63	4	3	9
19	7x46	angiotensin_off	6.9325	4.63	5	1	9
20	7x49	angiotensin_off	6.1905	4.78	5	3	9
21	7x52	angiotensin_off	4.6725	7.28	4	2	8
22	7x54	angiotensin_off	4.16188	3.01	4	1	7
23	NT	Shared	7.0015	20.9243	10	7	4
24	1x35	Shared	7.255	3.885	4	6	6
25	1x39	Shared	7.05938	5.398	4	5	7
26	2x42	Shared	5.7115	5.04	5	5	7
27	2x50	Shared	7.0885	5.61	5	5	9
28	2x60	Shared	9.425	7.2025	4	4	7
29	E1x50	Shared	7.88042	11.054	6	5	9
30	E1x52	Shared	7.812	7.568	5	5	6
31	3x51	Shared	6.24875	7.086	4	5	8
32	4x50	Shared	4.335	5.7175	4	4	9
33	E2	Shared	16.2171	29.847	12	10	4
34	5x58	Shared	5.1085	5.368	5	5	9
35	6x48	Shared	6.9175	4.906	5	5	8
36	6x51	Shared	5.997	6.46	5	6	6
37	7x53	Shared	5.58625	5.706	4	5	9
38	8x50	Shared	4.68375	4.1075	4	4	8
39	Lig	Shared	8.5875	13.0471	13	21	0
40	1x28	angiotensin_on	4.58333	7.3075	3	4	4
41	1x46	angiotensin_on	2.94	1.8025	1	4	8
42	1x53	angiotensin_on	4.46667	2.73	3	4	9
43	1x60	angiotensin_on	6.0575	6.816	2	5	4
44	2x41	angiotensin_on	1.625	3.2175	1	4	6
45	2x46	angiotensin_on	6.65375	4.3125	2	4	9
46	2x57	angiotensin_on	7.33875	5.73	2	4	8
47	2x63	angiotensin_on	7.18417	7.5575	3	4	5
48	E1	angiotensin_on	6.4425	8.076	3	5	4
49	3x34	angiotensin_on	3.995	4.4075	3	4	5
50	3x37	angiotensin_on	7.37667	5.62	3	5	7
51	I2x57	angiotensin_on	0.8	5.82	1	5	6
52	E2x52	angiotensin_on	9.2775	8.0725	3	4	4
53	5x43	angiotensin_on	2.79875	11.98	2	4	5
54	5x47	angiotensin_on	7.65583	5.795	3	4	8
55	5x50	angiotensin_on	3.455	3.1325	3	4	8
56	5x62	angiotensin_on	3.99	5.268	2	5	5
57	I3	angiotensin_on	5.265	3.99875	3	8	0
58	6x34	angiotensin_on	3.32417	6.678	3	5	6
59	6x43	angiotensin_on	4.52	7.275	3	4	6
60	6x45	angiotensin_on	8.08	8.585	2	4	5
61	6x49	angiotensin_on	2.84	5.2025	3	4	5
62	8x53	angiotensin_on	7.46	7.37	1	6	5

Orange: nodes, hubs and links specific of angiotensin_off network

Green: nodes, hubs and links shared by both networks

Purple: nodes, hubs and links specific of angiotensin_on network

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Owner: the name of the network the link belong to or "Shared" if the corresponding link is present in both networks.

Recurrence: the relative Recurrence in the filtered pool of shortest paths.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Owner	angiotensin_off Recurrence	angiotensin_on Recurrence	angiotensin_off Hub1?	angiotensin_on Hub1?	angiotensin_off Hub2?	angiotensin_on Hub2?	ConSurf1	ConSurf2
1	1x35	1x39	angiotensin_off	11.2399	0.684913	Yes	Yes	Yes	Yes	6	7
2	1x39	7x39	angiotensin_off	15.1486	3.4114	Yes	Yes	No	No	7	5
3	1x42	7x39	angiotensin_off	11.83	0	No	No	No	No	7	5
4	1x43	1x47	angiotensin_off	14.3675	4.74698	No	No	No	No	6	6
5	1x47	2x51	angiotensin_off	19.1023	1.58584	No	No	No	No	6	7
6	1x50	2x51	angiotensin_off	21.4593	0	No	No	No	No	9	7
7	2x50	7x46	angiotensin_off	37.7152	2.57369	Yes	Yes	Yes	No	9	9
8	2x53	7x46	angiotensin_off	36.2399	0	Yes	No	Yes	No	6	9
9	2x53	3x32	angiotensin_off	18.1755	0	Yes	No	Yes	No	6	6
10	2x63	Lig	angiotensin_off	38.0346	8.98027	No	Yes	Yes	Yes	5	0
11	2x63	E1	angiotensin_off	24.8334	0.223914	No	Yes	No	Yes	5	4
12	E1	NT	angiotensin_off	19.7167	0.179131	No	Yes	Yes	Yes	4	4
13	2x53	7x42	angiotensin_off	10.3305	0	Yes	No	Yes	No	6	7
14	7x42	Lig	angiotensin_off	17.0265	0	Yes	No	Yes	Yes	7	0
15	3x35	7x46	angiotensin_off	13.3921	0	Yes	No	Yes	No	8	9
16	3x35	7x42	angiotensin_off	11.5558	0	Yes	No	Yes	No	8	7
17	1x57	7x54	angiotensin_off	28.2109	0	No	No	Yes	No	7	7
18	1x53	7x54	angiotensin_off	35.5283	0	No	Yes	Yes	No	9	7
19	1x53	7x53	angiotensin_off	38.3505	0	No	Yes	Yes	Yes	9	9
20	6x40	7x49	angiotensin_off	100	0	No	No	Yes	No	8	9
21	7x45	7x49	angiotensin_off	48.0943	0	Yes	No	Yes	No	9	9
22	6x44	7x45	angiotensin_off	41.0094	0	No	No	Yes	No	9	9
23	6x48	Lig	angiotensin_off	75.368	0	Yes	Yes	Yes	Yes	8	0
24	3x43	7x49	angiotensin_off	38.1838	0	No	No	Yes	No	8	9
25	3x43	6x44	angiotensin_off	38.2637	0	No	No	No	No	8	9
26	2x38	2x42	angiotensin_off	23.4726	8.28482	Yes	No	Yes	Yes	7	7
27	2x42	4x46	angiotensin_off	24.8403	0	Yes	Yes	Yes	No	7	7
28	2x45	4x46	angiotensin_off	25.0972	5.43189	No	No	Yes	No	9	7
29	2x45	3x42	angiotensin_off	22.3861	6.78328	No	No	No	No	9	7
30	3x42	4x49	angiotensin_off	26.3954	7.06515	No	No	No	No	7	7
31	3x41	4x49	angiotensin_off	26.8051	0	No	No	No	No	5	7
32	3x46	7x53	angiotensin_off	70.5013	0	Yes	No	Yes	Yes	9	9
33	2x60	E1x50	angiotensin_off	25.1979	0	Yes	Yes	Yes	Yes	7	9
34	2x63	E1x50	angiotensin_off	18.2206	8.30853	No	Yes	Yes	Yes	5	9
35	2x60	Lig	angiotensin_off	16.9154	5.12631	Yes	Yes	Yes	Yes	7	0
36	2x59	E1x52	angiotensin_off	10.9483	0.134348	No	No	Yes	Yes	6	6
37	E1x50	E1x52	angiotensin_off	32.6923	5.60048	Yes	Yes	Yes	Yes	9	6
38	3x24	E1x52	angiotensin_off	10.9553	1.12747	No	No	Yes	Yes	5	6
39	4x65	E2x52	angiotensin_off	34.1121	2.09162	No	No	No	Yes	5	4
40	E2	E2x52	angiotensin_off	22.1293	0.492611	Yes	Yes	No	Yes	4	4
41	5x49	5x53	angiotensin_off	10.4311	0	No	No	No	No	6	7
42	3x44	5x53	angiotensin_off	16.9016	2.11006	No	No	No	No	7	7
43	3x44	5x54	angiotensin_off	18.5886	0	No	No	No	No	7	8
44	3x46	6x37	angiotensin_off	64.85	0	Yes	No	No	No	9	7
45	3x51	5x57	angiotensin_off	33.1575	0	Yes	Yes	No	No	8	7
46	3x47	5x57	angiotensin_off	34.7681	1.09586	No	No	No	No	9	7
47	3x51	3x55	angiotensin_off	23.8441	2.17855	Yes	Yes	No	No	8	7
48	3x54	5x64	angiotensin_off	19.2759	0	No	No	No	No	8	5
49	3x55	5x64	angiotensin_off	22.2994	1.09059	No	No	No	No	7	5
50	3x54	5x61	angiotensin_off	17.5958	0.152788	No	No	No	No	8	8
51	6x51	6x52	angiotensin_off	36.7988	0	Yes	Yes	No	No	6	8
52	6x51	Lig	angiotensin_off	40.5269	6.69108	Yes	Yes	Yes	Yes	6	0
53	5x47	6x52	angiotensin_off	11.8509	3.08738	No	Yes	No	No	8	8
54	5x61	6x34	angiotensin_off	15.9053	0	No	No	No	Yes	8	6
55	3x50	8x50	angiotensin_off	16.787	0	No	No	Yes	Yes	9	8
56	3x49	3x50	angiotensin_off	18.7448	0	No	No	No	No	8	9
57	2x38	3x49	angiotensin_off	20.6158	0	Yes	No	No	No	7	8
58	5x44	6x56	angiotensin_off	17.4431	1.53579	Yes	No	No	No	4	5
59	5x44	6x52	angiotensin_off	24.5453	2.54472	Yes	No	No	No	4	8
60	6x56	6x60	angiotensin_off	16.0025	1.13274	No	No	No	No	5	3
61	6x60	E3	angiotensin_off	14.555	0.84297	No	No	Yes	No	3	1
62	8x50	8x54	angiotensin_off	10.8442	0	Yes	Yes	No	No	8	7
63	2x40	I1	angiotensin_off	10.4728	0	Yes	No	No	No	8	0
64	1x57	2x40	angiotensin_off	14.5237	0	No	No	Yes	No	7	8
65	3x27	3x28	angiotensin_off	10.9726	0	No	No	No	No	6	6
66	5x35	5x39	angiotensin_off	15.7803	0	No	No	No	No	1	5
67	5x39	5x42	angiotensin_off	13.1526	0	No	No	No	No	5	3
68	4x60	5x42	angiotensin_off	10.5179	0	No	No	No	No	6	3
69	1x39	Lig	angiotensin_off	22.7055	0	Yes	Yes	Yes	Yes	7	0
70	4x65	Lig	angiotensin_off	36.1983	0	No	No	Yes	Yes	5	0
71	4x64	E2x52	angiotensin_off	10.7644	0	Yes	No	No	Yes	4	4
72	7x45	7x46	angiotensin_off	10.4103	0	Yes	No	Yes	No	9	9
73	2x42	3x46	angiotensin_off	19.9077	3.51677	Yes	Yes	Yes	No	7	9
74	2x60	3x32	angiotensin_off	10.143	0	Yes	Yes	Yes	No	7	6
75	1x50	2x50	Shared	28.4886	100	No	No	Yes	Yes	9	9
76	6x40	7x53	Shared	98.2713	55.9864	No	No	Yes	Yes	8	9
77	6x44	6x48	Shared	78.7941	82.0553	No	No	Yes	Yes	9	8
78	1x57	2x44	Shared	13.5657	17.921	No	No	Yes	No	7	5
79	3x37	3x41	Shared	28.5407	21.9515	No	Yes	No	No	7	5
80	3x37	Lig	Shared	29.9084	24.051	No	Yes	Yes	Yes	7	0
81	2x42	4x45	Shared	10.2819	12.0887	Yes	Yes	No	No	7	5
82	3x47	5x54	Shared	20.2687	90.2374	No	No	No	No	9	8
83	3x47	5x58	Shared	54.7834	90.7958	No	No	Yes	Yes	9	9
84	5x58	6x37	Shared	63.465	49.9144	Yes	Yes	No	No	9	7
85	2x50	7x49	Shared	16.1032	53.4628	Yes	Yes	Yes	No	9	9
86	7x35	Lig	angiotensin_on	0	10.7452	No	No	Yes	Yes	5	0
87	E2	Lig	angiotensin_on	0	11.5777	Yes	Yes	Yes	Yes	4	0
88	2x57	7x42	angiotensin_on	5.52277	11.3037	No	Yes	Yes	No	8	7
89	3x36	7x42	angiotensin_on	0	10.9929	No	No	Yes	No	7	7
90	3x36	Lig	angiotensin_on	8.08803	69.4002	No	No	Yes	Yes	7	0
91	2x46	2x50	angiotensin_on	1.87795	53.5997	No	Yes	Yes	Yes	9	9
92	2x46	7x53	angiotensin_on	0	54.5955	No	Yes	Yes	Yes	9	9
93	3x50	7x53	angiotensin_on	0	55.2093	No	No	Yes	Yes	9	9
94	3x50	5x58	angiotensin_on	0	55.5201	No	No	Yes	Yes	9	9
95	5x54	6x44	angiotensin_on	0	89.9739	No	No	No	No	8	9
96	3x36	6x48	angiotensin_on	0.954596	76.3521	No	No	Yes	Yes	7	8
97	7x49	7x53	angiotensin_on	0	54.5771	Yes	No	Yes	Yes	9	9
98	5x58	6x40	angiotensin_on	0	57.3773	Yes	Yes	No	No	9	8
99	1x50	7x50	angiotensin_on	4.81463	80.9278	No	No	No	No	9	9
100	1x53	7x55	angiotensin_on	0	46.7269	No	Yes	No	No	9	6
101	1x53	7x50	angiotensin_on	0	73.6888	No	Yes	No	No	9	9
102	1x53	1x57	angiotensin_on	0	20.4605	No	Yes	No	No	9	7
103	1x60	8x53	angiotensin_on	0	21.9673	No	Yes	No	Yes	4	5
104	8x50	8x53	angiotensin_on	0	32.0487	Yes	Yes	No	Yes	8	5
105	7x55	8x50	angiotensin_on	0	39.5854	No	No	Yes	Yes	6	8
106	2x40	I1x50	angiotensin_on	0	10.2711	Yes	No	No	No	8	7
107	2x44	I1x50	angiotensin_on	6.66134	12.8263	Yes	No	No	No	5	7
108	2x45	4x50	angiotensin_on	2.8499	12.9633	No	No	Yes	Yes	9	9
109	3x34	4x50	angiotensin_on	3.2977	15.3421	No	Yes	Yes	Yes	5	9
110	3x34	4x53	angiotensin_on	1.10386	19.3198	No	Yes	No	No	5	8
111	3x41	4x53	angiotensin_on	0	20.197	No	No	No	No	5	8
112	3x51	5x61	angiotensin_on	0	30.555	Yes	Yes	No	No	8	8
113	5x61	5x65	angiotensin_on	0	31.1925	No	No	No	No	8	8
114	5x65	6x34	angiotensin_on	9.43835	32.8232	No	No	No	Yes	8	6
115	5x62	6x34	angiotensin_on	4.9153	45.4783	No	Yes	No	Yes	5	6
116	5x62	6x37	angiotensin_on	0	49.2795	No	Yes	No	No	5	7
117	3x52	I2x57	angiotensin_on	0	24.0115	No	No	No	Yes	5	6
118	2x38	I2x57	angiotensin_on	0	14.4727	Yes	No	No	Yes	7	6
119	4x41	4x45	angiotensin_on	9.31339	10.4923	No	No	No	No	4	5
120	5x51	6x44	angiotensin_on	0	11.3406	No	No	No	No	6	9
121	1x46	1x50	angiotensin_on	0	17.921	No	Yes	No	No	8	9
122	1x45	1x46	angiotensin_on	0	10.2711	No	No	No	Yes	5	8
123	3x51	3x52	angiotensin_on	0	25.031	Yes	Yes	No	No	8	5

Here, those paths that begin and end at given residue pair(s) or that pass through a residue are used to generate a novel metapath. Such a path filtering is particularly recommended if some information on allosteric residues is available. The selection syntax for a residue pair ("Pairs") is C:C:c534,A:A:?600 (the lower-case "c" stands for cytosine and "?" indicates any non standard amino acid or nucleotide residue). Selection of more than one apical residue pair has the following syntax: C:C:c534,A:A:?600,C:C:c534,A:A:E41. Only one residue can be selected as a tail ("Tail"). For midway residue(s), each residue must be separated by a comma as well e.g. A:A:?600,A:A:E41.

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Node1	Node2	Owner	Net1LinkStrength	Net2LinkStrength	Comm1	Comm2	Node1Shell	Node2Shell
NT	NT	Shared	10.4075	17	2	1	1	1
E2	NT	Shared	9.0975	74.91	2	1	1	1
7x24	NT	Shared	3.64	7.28	0	1	2	1
7x31	NT	Shared	3.845	6.31	2	1	1	1
2x67	NT	angiotensin_off	17.135	0	2	0	2	1
E1	NT	Shared	4.3575	7.2	2	1	1	1
1x32	2x67	Shared	7.87	16.32	0	0	2	2
1x35	1x39	Shared	6.045	6.04	0	0	2	1
1x35	2x64	angiotensin_off	14.455	0	0	0	2	2
1x39	2x57	Shared	6.1525	8.21	0	0	1	2
1x39	7x39	Shared	8.5475	4.03	0	0	1	2
1x39	Lig	angiotensin_off	7.4925	0	0	0	1	0
2x53	3x32	angiotensin_off	3.965	0	1	0	2	1
2x53	3x35	Shared	8.02	1.56	1	0	2	2
2x53	7x42	angiotensin_off	9.045	0	1	0	2	1
2x60	E1x50	angiotensin_off	7.5	0	1	1	1	2
2x60	3x32	angiotensin_off	4.6425	0	1	1	1	1
2x60	Lig	Shared	20.705	16.21	1	1	1	0
2x63	E1	Shared	9.18	10.92	0	1	1	1
2x63	E1x50	Shared	8.925	10.61	0	1	1	2
2x63	Lig	Shared	3.4475	4.84	0	1	1	0
2x64	E1	Shared	5.79	7.49	2	0	2	1
E1x49	E2	Shared	14.3375	5.01	0	1	2	1
E1x50	E2x50	Shared	9.47	15.67	1	1	2	2
3x22	E2	Shared	9.925	12.72	0	1	2	1
3x26	E2	angiotensin_off	5.9125	0	2	0	2	1
3x29	4x65	Shared	7.6675	15.81	0	0	2	1
3x32	7x42	Shared	4.96	3.79	1	1	1	1
3x32	Lig	Shared	13.51	3.93	1	1	1	0
3x33	Lig	Shared	9.85	5.28	0	1	1	0
3x35	7x42	angiotensin_off	3.4875	0	1	0	2	1
3x36	6x48	Shared	10.905	3.42	1	1	1	1
3x36	Lig	Shared	6.0525	4.87	1	1	1	0
3x37	3x41	Shared	6.63	6.19	0	1	1	2
3x37	4x56	Shared	9.955	8.01	0	1	1	2
3x37	Lig	Shared	5.545	4.13	0	1	1	0
4x64	E2x52	angiotensin_off	9.22	0	2	0	2	1
4x64	E2	angiotensin_off	9.29	0	2	0	2	1
4x65	E2x52	Shared	7.19	17.1	0	0	1	1
4x65	Lig	angiotensin_off	18.89	0	0	0	1	0
E2	E2	Shared	53.735	65.49	2	1	1	1
E2	E2x52	Shared	11.4225	4.13	2	1	1	1
6x62	E2	Shared	4.7925	18.18	2	1	2	1
5x35	E2	angiotensin_off	12.1325	0	2	0	2	1
6x44	6x48	Shared	7.5175	5.01	0	0	2	1
6x44	7x45	angiotensin_off	4.5325	0	0	0	2	2
6x48	7x41	angiotensin_off	9.0825	0	1	0	1	2
6x48	7x42	angiotensin_off	3.6175	0	1	0	1	1
6x51	6x55	Shared	7.9275	6.85	1	1	1	2
6x51	7x37	Shared	5.1425	8.21	1	1	1	2
6x51	7x38	Shared	5.895	3.98	1	1	1	1
6x58	6x62	angiotensin_off	8.48	0	0	0	1	2
7x38	Lig	Shared	7.615	6.41	1	1	1	0
7x42	Lig	angiotensin_off	4.845	0	1	0	1	0
2x56	2x60	Shared	4.8525	4.85	0	0	2	1
3x33	4x61	Shared	4.3525	3.42	0	1	1	2
E2	E2x51	angiotensin_off	4.55	0	2	1	1	1
2x64	NT	angiotensin_off	8.25	0	2	0	2	1
2x53	3x36	angiotensin_off	3.535	0	1	0	2	1
2x57	7x42	Shared	8.525	8.21	0	0	2	1
4x64	5x35	Shared	4.01	2.57	2	0	2	2
5x32	E2	angiotensin_off	5.675	0	0	0	2	1
5x36	6x62	angiotensin_off	8.65	0	0	1	2	2
5x43	Lig	Shared	4.29	24.77	0	1	1	0
6x48	Lig	angiotensin_off	3.465	0	1	0	1	0
6x51	6x52	angiotensin_off	5.09	0	1	1	1	2
6x51	Lig	Shared	5.93	7.92	1	1	1	0
1x35	7x35	Shared	3.39	5.08	0	0	2	1
3x33	4x57	Shared	3.23	6.52	0	1	1	2
7x30	7x31	angiotensin_off	2.86	0	0	0	2	1
6x58	7x34	angiotensin_off	2.7725	0	0	0	1	1
5x39	5x42	angiotensin_off	2.5725	0	0	0	2	2
7x27	7x31	angiotensin_off	2.485	0	0	0	2	1
5x35	5x39	angiotensin_off	2.35	0	2	0	2	2
6x61	7x30	Shared	2.305	4.61	0	1	1	2
7x32	NT	angiotensin_off	1.615	0	2	4	2	1
5x40	5x43	angiotensin_off	1.3075	0	0	0	2	1
1x33	NT	angiotensin_off	1.26	0	0	0	2	1
Lig	NT	angiotensin_on	0	16.77	1	1	0	1
1x32	E1	angiotensin_on	0	4.13	0	0	2	1
1x39	7x38	angiotensin_on	0	6.04	0	0	1	1
2x60	2x63	angiotensin_on	0	3.86	1	1	1	1
2x60	3x28	angiotensin_on	0	3.89	1	1	1	2
2x67	E1x49	angiotensin_on	0	10.47	2	0	2	2
E1	Lig	angiotensin_on	0	10.64	2	1	1	0
3x22	3x26	angiotensin_on	0	8.39	0	1	2	2
3x36	7x42	angiotensin_on	0	7.03	1	1	1	1
3x37	5x42	angiotensin_on	0	4.99	0	1	1	2
3x37	5x43	angiotensin_on	0	4.78	0	1	1	1
3x40	6x48	angiotensin_on	0	4.9	0	0	2	1
4x64	5x36	angiotensin_on	0	4.58	2	0	2	2
E2	E2x50	angiotensin_on	0	5.12	2	1	1	2
E2	Lig	angiotensin_on	0	34.34	2	1	1	0
E2x51	Lig	angiotensin_on	0	4.95	0	0	1	0
5x39	E2x52	angiotensin_on	0	4.87	0	0	2	1
E2x52	Lig	angiotensin_on	0	6.19	2	1	1	0
5x36	E2	angiotensin_on	0	13.08	0	1	2	1
5x43	6x51	angiotensin_on	0	7.86	0	1	1	1
5x43	6x55	angiotensin_on	0	10.51	0	1	1	2
6x48	6x52	angiotensin_on	0	3.29	1	0	1	2
6x48	7x45	angiotensin_on	0	7.91	1	0	1	2
6x51	7x34	angiotensin_on	0	3.94	1	1	1	1
6x58	Lig	angiotensin_on	0	14.05	0	0	1	0
6x61	E3	angiotensin_on	0	5.89	0	1	1	2
6x61	Lig	angiotensin_on	0	5.01	0	1	1	0
7x24	7x27	angiotensin_on	0	3.61	0	1	2	2
7x31	Lig	angiotensin_on	0	22.07	2	1	1	0
7x34	Lig	angiotensin_on	0	13.98	0	1	1	0
7x35	Lig	angiotensin_on	0	7.63	0	1	1	0
1x39	2x61	angiotensin_on	0	2.67	0	0	1	2
5x39	5x40	angiotensin_on	0	1.71	0	0	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Difference Members
	Id	Description
	angiotensin_off	at1_off at2_off
	angiotensin_on	at1_on

Network Difference
Value	angiotensin_off	angiotensin_on
I_min	3.4225	3.07
Number of Linked Nodes	276	253
Number of Specific Nodes	25 (9.06%)	2 (0.79%)
Number of Shared Nodes	251 (90.94%)	251 (99.21%)
Number of Links	310	294
Number of Specific Links	158 (50.97%)	142 (48.30%)
Number of Shared Links	152 (49.03%)	152 (51.70%)
Number of Hubs	39	40
Number of Specific Hubs	22 (56.41%)	23 (57.50%)
Number of Shared Hubs	17 (43.59%)	17 (42.50%)
Average % Shared Neighbours (Jaccard)	35.58
Average % Shared Neighbours (Otsuka)	45.33
Average % Shared Neighbours (Overlap Coefficient)	55.28
Average % Shared Cliques (k3-6)	77.50
Graphlets Similarity	0.587655

Paths Difference
Value	angiotensin_off	angiotensin_on
Number Of Nodes in MetaPath	81	49
Specific Nodes in MetaPath	52 (64.20%)	20 (40.82%)
Shared Nodes in MetaPath	251 (90.94%)	251 (90.94%)
Number Of Links MetaPath	85	49
Specific Links in MetaPath	74 (87.06%)	38 (77.55%)
Shared Links in MetaPath	152 (49.03%)	152 (49.03%)
Number of Shortest Paths	65634	68830
Length Of Smallest Path	3	3
Average Path Length	13.9001	15.3139
Length of Longest Path	32	33
Minimum Path Strength	0.92	1.21
Average Path Strength	6.03463	5.63753
Maximum Path Strength	16.2	46.545
Minimum Path Correlation	0.7	0.7
Average Path Correlation	0.908844	0.932262
Maximum Path Correlation	0.985	1
Minimum % Of Corr. Nodes	3.33333	4.34783
Average % Of Corr. Nodes	41.2918	46.8589
Maximum % Of Corr. Nodes	100	100
Minimum Path Hubs %	0	0
Average Path Hubs %	44.3989	42.1279
Maximum Path Hubs %	100	100

Details about the values in these tables can be found in the corresponding documentation page .

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