psnGPCR

Code	AND
Name	Prasterone
Synonyms	DHEA
Identifier	(3S,8R,9S,10R,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one
Formula	C19 H28 O2
Molecular Weight	288.424
SMILES	C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CC=C4[C@@]3(CC[C@@H](C4)O)C
PubChem	5881
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	6
Total Bonds	52
Total Aromatic Bonds	0
Networks	3

This ligand is also present in the following 3 networks:

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7XKD

Adhesion

ADGRG2

Mus musculus

Betahydroxyandrosterone

Gs/Beta1/Gamma2

2.4

2022-08-10

10.1038/s41589-022-01084-6

A 2D representation of the interactions of AND in 7XKD
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L620	R:R:Y854	3.52	0	No	Yes	9	9	1	2
L:L:?1	R:R:L620	5.51	0	Yes	No	0	9	0	1
R:R:T624	R:R:T861	4.71	0	No	Yes	9	8	1	2
L:L:?1	R:R:T624	5.87	0	Yes	No	0	9	0	1
L:L:?1	R:R:N763	12.29	0	Yes	No	0	5	0	1
R:R:P766	R:R:T765	5.25	0	No	No	5	5	2	1
L:L:?1	R:R:T765	10.26	0	Yes	No	0	5	0	1
R:R:F856	R:R:W838	4.01	15	Yes	Yes	9	9	1	2
R:R:N860	R:R:W838	24.86	15	No	Yes	9	9	2	2
R:R:A841	R:R:F856	4.16	0	No	Yes	9	9	2	1
L:L:?1	R:R:M853	5.63	0	Yes	No	0	8	0	1
R:R:F856	R:R:N860	7.25	15	Yes	No	9	9	1	2
L:L:?1	R:R:F856	8.48	0	Yes	Yes	0	9	0	1
R:R:F840	R:R:F856	3.22	0	No	Yes	9	9	2	1
R:R:A844	R:R:M853	3.22	0	No	No	9	8	2	1
L:L:?1	R:R:M617	2.81	0	Yes	No	0	4	0	1
R:R:T621	R:R:T765	1.57	0	No	No	9	5	2	1

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	1.00
Average Interaction Strength	7.26
Average Nodes In Shell	17.00
Average Hubs In Shell	5.00
Average Links In Shell	17.00
Average Links Mediated by Hubs In Shell	14.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7XKE

Adhesion

ADGRG2

Mus musculus

Betahydroxyandrosterone

chim(NtGi1-Gs)/Beta1/Gamma2

2.9

2022-08-10

10.1038/s41589-022-01084-6

A 2D representation of the interactions of AND in 7XKE
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L620	5.51	Yes	No	0	9	0	1
R:R:N763	R:R:W771	13.56	No	Yes	5	9	1	2
L:L:?1	R:R:N763	4.1	Yes	No	0	5	0	1
R:R:P766	R:R:T765	8.74	No	No	5	5	2	1
L:L:?1	R:R:T765	5.87	Yes	No	0	5	0	1
R:R:A841	R:R:F856	5.55	No	No	9	9	2	1
L:L:?1	R:R:M853	4.22	Yes	No	0	8	0	1
R:R:F856	R:R:N860	16.92	No	No	9	9	1	2
L:L:?1	R:R:F856	7.27	Yes	No	0	9	0	1
L:L:?1	R:R:P762	3.27	Yes	No	0	3	0	1
R:R:P762	R:R:W845	2.7	No	No	3	8	1	2
R:R:M853	R:R:Y854	2.39	No	Yes	8	9	1	2
R:R:A844	R:R:M853	1.61	No	No	9	8	2	1
R:R:T621	R:R:T765	1.57	No	No	9	5	2	1
L:L:?1	R:R:A857	1.57	Yes	No	0	7	0	1

Statistics	Value
Average Number Of Links	7.00
Average Number Of Links With An Hub	0.00
Average Interaction Strength	4.54
Average Nodes In Shell	16.00
Average Hubs In Shell	3.00
Average Links In Shell	15.00
Average Links Mediated by Hubs In Shell	9.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Show

PDB

Class

SubFamily

Type

SubType

Species

Orthosteric Ligand

Other Ligand(s)

Protein Partners

Resolution

Date

DOI

7XKF

Adhesion

ADGRG2

Mus musculus

Betahydroxyandrosterone

Gs/Beta1/Gamma2

2.4

2022-08-10

10.1038/s41589-022-01084-6

A 2D representation of the interactions of AND in 7XKF
colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

(Click to enlarge 🔍)

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L620	R:R:Y854	3.52	6	Yes	Yes	9	9	1	2
L:L:?1	R:R:L620	4.13	6	Yes	Yes	0	9	0	1
R:R:T624	R:R:T861	4.71	6	No	Yes	9	8	1	1
L:L:?1	R:R:T624	11.73	6	Yes	No	0	9	0	1
R:R:G627	R:R:T861	3.64	0	No	Yes	9	8	2	1
R:R:F671	R:R:F769	4.29	0	No	Yes	9	9	1	2
L:L:?1	R:R:F671	16.96	6	Yes	No	0	9	0	1
R:R:F701	R:R:W838	10.02	0	No	Yes	9	9	2	1
R:R:M704	R:R:W838	5.82	6	No	Yes	9	9	2	1
R:R:M704	R:R:Q863	5.44	6	No	Yes	9	9	2	2
R:R:P766	R:R:T765	5.25	0	No	No	5	5	2	1
L:L:?1	R:R:T765	11.73	6	Yes	No	0	5	0	1
R:R:F769	R:R:P766	7.22	0	Yes	No	9	5	2	2
R:R:F856	R:R:W838	4.01	6	Yes	Yes	9	9	1	1
R:R:N860	R:R:W838	24.86	6	No	Yes	9	9	2	1
R:R:Q863	R:R:W838	6.57	6	Yes	Yes	9	9	2	1
L:L:?1	R:R:W838	7.93	6	Yes	Yes	0	9	0	1
R:R:A841	R:R:F856	4.16	0	No	Yes	9	9	2	1
R:R:F856	R:R:N860	7.25	6	Yes	No	9	9	1	2
L:L:?1	R:R:F856	16.96	6	Yes	Yes	0	9	0	1
L:L:?1	R:R:T861	4.4	6	Yes	Yes	0	8	0	1
R:R:C628	R:R:T861	3.38	0	No	Yes	9	8	2	1
R:R:F840	R:R:F856	3.22	0	No	Yes	9	9	2	1
R:R:G835	R:R:W838	2.81	0	No	Yes	9	9	2	1
R:R:A857	R:R:T861	1.68	0	No	Yes	7	8	2	1
R:R:T621	R:R:T765	1.57	0	No	No	9	5	2	1
R:R:L620	R:R:M617	1.41	6	Yes	No	9	4	1	1
L:L:?1	R:R:M617	1.41	6	Yes	No	0	4	0	1
R:R:L620	R:R:M853	1.41	6	Yes	No	9	8	1	2

Statistics	Value
Average Number Of Links	8.00
Average Number Of Links With An Hub	4.00
Average Interaction Strength	9.41
Average Nodes In Shell	24.00
Average Hubs In Shell	8.00
Average Links In Shell	29.00
Average Links Mediated by Hubs In Shell	27.00

Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)

Location of the nodes interacting with this ligand (click to enlarge 🔍)

Statistics	Value
Average Number Of Links	7.33
Average Number Of Links With An Hub	1.67
Average Interaction Strength	7.07
Average Nodes In Shell	19.00
Average Hubs In Shell	5.33
Average Links In Shell	20.33
Average Links Mediated by Hubs In Shell	16.67

Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

Location of the nodes interacting with this ligand

(Click to enlarge 🔍)