CodeSA0
NameSalicin
SynonymsD-salicin
Identifier
FormulaC13 H18 O7
Molecular Weight286.278
SMILES
PubChem439503
Formal Charge0
Total Atoms38
Total Chiral Atoms5
Total Bonds39
Total Aromatic Bonds6
Networks8
 missing image

This ligand is also present in the following 8 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9K6L T2 Sensory Taste2 TAS2R16 Homo Sapiens SA0 - Gi2/Beta1/Gamma2 2.77 2025-04-02 To be published

A 2D representation of the interactions of SA0 in 9K6L
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:Q60 R:R:Y14 3.38 1 Yes Yes 7 4 2 2
R:R:S63 R:R:Y14 3.82 1 Yes Yes 5 4 1 2
R:R:N67 R:R:Y14 4.65 1 Yes Yes 3 4 1 2
R:R:E262 R:R:Y14 6.73 1 Yes Yes 3 4 1 2
R:R:Y14 R:R:Y266 9.93 1 Yes Yes 4 4 2 1
R:R:L59 R:R:W85 12.53 0 No Yes 5 5 2 1
R:R:Q60 R:R:Y266 11.27 1 Yes Yes 7 4 2 1
R:R:N67 R:R:S63 4.47 1 Yes Yes 3 5 1 1
R:R:S63 R:R:W85 4.94 1 Yes Yes 5 5 1 1
R:R:S63 R:R:Y266 11.45 1 Yes Yes 5 4 1 1
L:L:?1 R:R:S63 5.93 1 Yes Yes 0 5 0 1
R:R:N66 R:R:N80 4.09 0 Yes No 5 3 1 2
R:R:N66 R:R:T82 4.39 0 Yes No 5 1 1 2
L:L:?1 R:R:N66 7.23 1 Yes Yes 0 5 0 1
R:R:L258 R:R:N67 6.87 1 Yes Yes 2 3 2 1
R:R:E262 R:R:N67 17.09 1 Yes Yes 3 3 1 1
L:L:?1 R:R:N67 7.23 1 Yes Yes 0 3 0 1
R:R:N89 R:R:W85 10.17 1 Yes Yes 8 5 2 1
R:R:I243 R:R:W85 4.7 1 Yes Yes 3 5 2 1
R:R:W85 R:R:Y266 7.72 1 Yes Yes 5 4 1 1
L:L:?1 R:R:W85 37.46 1 Yes Yes 0 5 0 1
R:R:E86 R:R:H181 17.23 0 No No 4 2 1 2
L:L:?1 R:R:E86 11.33 1 Yes No 0 4 0 1
R:R:I243 R:R:V265 4.61 1 Yes Yes 3 4 2 2
R:R:T246 R:R:W261 6.06 0 No Yes 4 4 1 2
L:L:?1 R:R:T246 6.79 1 Yes No 0 4 0 1
L:L:?1 R:R:I247 5.63 1 Yes No 0 4 0 1
R:R:E262 R:R:R255 3.49 1 Yes No 3 5 1 2
R:R:E262 R:R:Y266 5.61 1 Yes Yes 3 4 1 1
L:L:?1 R:R:E262 15.69 1 Yes Yes 0 3 0 1
R:R:V265 R:R:Y266 6.31 1 Yes Yes 4 4 2 1
R:R:I269 R:R:Y266 6.04 0 No Yes 8 4 2 1
L:L:?1 R:R:Y266 6.17 1 Yes Yes 0 4 0 1
R:R:L81 R:R:N66 2.75 0 No Yes 2 5 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub6.00
Average Interaction Strength11.50
Average Nodes In Shell24.00
Average Hubs In Shell14.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell33.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9KPD T2 Sensory Taste2 TAS2R16 Homo Sapiens SA0 - chim(Gs-CtGt3)/Beta1/Gamma2 2.84 2025-04-02 To be published

A 2D representation of the interactions of SA0 in 9KPD
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S63 R:R:Y14 3.82 2 Yes Yes 5 4 1 2
R:R:N67 R:R:Y14 5.81 2 Yes Yes 3 4 2 2
R:R:E262 R:R:Y14 19.08 2 Yes Yes 3 4 1 2
R:R:Y14 R:R:Y266 14.89 2 Yes Yes 4 4 2 2
R:R:L59 R:R:W85 21.64 2 No Yes 5 5 2 1
R:R:L59 R:R:Y266 5.86 2 No Yes 5 4 2 2
R:R:A62 R:R:W85 3.89 0 No Yes 4 5 2 1
R:R:N67 R:R:S63 4.47 2 Yes Yes 3 5 2 1
R:R:S63 R:R:W85 3.71 2 Yes Yes 5 5 1 1
R:R:S63 R:R:Y266 11.45 2 Yes Yes 5 4 1 2
L:L:?1 R:R:S63 3.95 2 Yes Yes 0 5 0 1
L:L:?1 R:R:N66 5.42 2 Yes No 0 5 0 1
R:R:E262 R:R:N67 11.83 2 Yes Yes 3 3 1 2
R:R:N80 R:R:T82 4.39 0 No No 3 1 2 1
R:R:N89 R:R:W85 9.04 2 Yes Yes 8 5 2 1
R:R:W85 R:R:Y239 3.86 2 Yes Yes 5 7 1 2
R:R:I243 R:R:W85 3.52 2 Yes Yes 3 5 2 1
R:R:W85 R:R:Y266 7.72 2 Yes Yes 5 4 1 2
L:L:?1 R:R:W85 30.71 2 Yes Yes 0 5 0 1
R:R:E86 R:R:I90 8.2 2 Yes No 4 6 1 2
R:R:E86 R:R:I141 5.47 2 Yes No 4 5 1 2
R:R:E86 R:R:H181 4.92 2 Yes Yes 4 2 1 1
L:L:?1 R:R:E86 3.49 2 Yes Yes 0 4 0 1
R:R:N89 R:R:Y239 11.63 2 Yes Yes 8 7 2 2
R:R:I243 R:R:N89 7.08 2 Yes Yes 3 8 2 2
R:R:I141 R:R:S144 4.64 0 No No 5 3 2 2
R:R:H181 R:R:S144 6.97 2 Yes No 2 3 1 2
R:R:H181 R:R:I247 3.98 2 Yes No 2 4 1 1
L:L:?1 R:R:H181 3.38 2 Yes Yes 0 2 0 1
R:R:I243 R:R:Y239 13.3 2 Yes Yes 3 7 2 2
L:L:?1 R:R:T246 6.79 2 Yes No 0 4 0 1
L:L:?1 R:R:I247 3.76 2 Yes No 0 4 0 1
R:R:F252 R:R:K254 3.72 2 No Yes 2 3 2 1
R:R:F252 R:R:W261 37.08 2 No Yes 2 4 2 2
R:R:K254 R:R:L258 4.23 2 Yes No 3 2 1 2
R:R:K254 R:R:W261 9.28 2 Yes Yes 3 4 1 2
R:R:E262 R:R:K254 5.4 2 Yes Yes 3 3 1 1
L:L:?1 R:R:K254 7.42 2 Yes Yes 0 3 0 1
R:R:E262 R:R:Y266 4.49 2 Yes Yes 3 4 1 2
L:L:?1 R:R:E262 6.97 2 Yes Yes 0 3 0 1
R:R:I247 R:R:T182 3.04 2 No No 4 4 1 2
L:L:?1 R:R:T82 2.91 2 Yes No 0 1 0 1
R:R:H181 R:R:Q177 2.47 2 Yes Yes 2 1 1 2
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub6.00
Average Interaction Strength7.48
Average Nodes In Shell28.00
Average Hubs In Shell15.00
Average Links In Shell43.00
Average Links Mediated by Hubs In Shell40.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9KPE T2 Sensory Taste2 TAS2R16 Homo Sapiens SA0 - Gi1/Beta1/Gamma2 3.35 2025-04-02 To be published

A 2D representation of the interactions of SA0 in 9KPE
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S63 R:R:Y14 3.82 1 No Yes 5 4 2 2
R:R:N67 R:R:Y14 9.3 1 No Yes 3 4 2 2
R:R:E262 R:R:Y14 14.59 1 Yes Yes 3 4 1 2
R:R:Y14 R:R:Y266 15.89 1 Yes Yes 4 4 2 1
R:R:L59 R:R:W85 10.25 0 No Yes 5 5 2 1
R:R:Q60 R:R:S63 5.78 1 Yes No 7 5 2 2
R:R:Q60 R:R:Y266 11.27 1 Yes Yes 7 4 2 1
R:R:A62 R:R:W85 3.89 0 No Yes 4 5 2 1
R:R:S63 R:R:Y266 11.45 1 No Yes 5 4 2 1
R:R:L65 R:R:N66 4.12 0 No No 4 5 2 1
L:L:?1 R:R:N66 8.13 1 Yes No 0 5 0 1
R:R:E262 R:R:N67 14.46 1 Yes No 3 3 1 2
L:L:?1 R:R:T82 4.85 1 Yes No 0 1 0 1
R:R:N89 R:R:W85 11.3 1 Yes Yes 8 5 2 1
R:R:W85 R:R:Y239 4.82 1 Yes Yes 5 7 1 2
R:R:I243 R:R:W85 5.87 1 No Yes 3 5 2 1
R:R:W85 R:R:Y266 8.68 1 Yes Yes 5 4 1 1
L:L:?1 R:R:W85 40.45 1 Yes Yes 0 5 0 1
R:R:E86 R:R:I90 4.1 0 Yes No 4 6 1 2
R:R:E86 R:R:H181 14.77 0 Yes Yes 4 2 1 2
R:R:E86 R:R:L185 3.98 0 Yes No 4 5 1 2
L:L:?1 R:R:E86 4.36 1 Yes Yes 0 4 0 1
R:R:L185 R:R:N89 5.49 0 No Yes 5 8 2 2
R:R:N89 R:R:Y239 6.98 1 Yes Yes 8 7 2 2
R:R:F178 R:R:I247 6.28 0 Yes No 4 4 2 1
R:R:I247 R:R:L185 5.71 0 No No 4 5 1 2
R:R:I243 R:R:Y239 12.09 1 No Yes 3 7 2 2
R:R:T242 R:R:W261 6.06 1 No Yes 6 4 2 2
R:R:T242 R:R:V265 4.76 1 No Yes 6 4 2 1
R:R:I243 R:R:T246 4.56 1 No Yes 3 4 2 1
R:R:T246 R:R:W261 4.85 0 Yes Yes 4 4 1 2
L:L:?1 R:R:T246 4.85 1 Yes Yes 0 4 0 1
L:L:?1 R:R:I247 3.76 1 Yes No 0 4 0 1
R:R:V265 R:R:W261 4.9 1 Yes Yes 4 4 1 2
R:R:E262 R:R:Y266 7.86 1 Yes Yes 3 4 1 1
L:L:?1 R:R:E262 15.69 1 Yes Yes 0 3 0 1
R:R:V265 R:R:Y266 8.83 1 Yes Yes 4 4 1 1
L:L:?1 R:R:V265 3.92 1 Yes Yes 0 4 0 1
R:R:I269 R:R:Y266 6.04 0 No Yes 8 4 2 1
L:L:?1 R:R:Y266 7.71 1 Yes Yes 0 4 0 1
R:R:K254 R:R:T246 3 0 No Yes 3 4 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub6.00
Average Interaction Strength10.41
Average Nodes In Shell28.00
Average Hubs In Shell14.00
Average Links In Shell41.00
Average Links Mediated by Hubs In Shell39.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9KPF T2 Sensory Taste2 TAS2R16 Homo Sapiens SA0 - Gi1/Beta1/Gamma2 3.15 2025-04-02 To be published

A 2D representation of the interactions of SA0 in 9KPF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S63 R:R:Y14 2.54 1 Yes Yes 5 4 1 2
R:R:N67 R:R:Y14 10.47 1 Yes Yes 3 4 1 2
R:R:E262 R:R:Y14 15.71 1 Yes Yes 3 4 1 2
R:R:Y14 R:R:Y266 12.91 1 Yes Yes 4 4 2 2
R:R:L59 R:R:W85 6.83 0 No Yes 5 5 2 1
R:R:N67 R:R:S63 5.96 1 Yes Yes 3 5 1 1
R:R:S63 R:R:W85 4.94 1 Yes Yes 5 5 1 1
R:R:S63 R:R:Y266 8.9 1 Yes Yes 5 4 1 2
L:L:?1 R:R:S63 4.94 1 Yes Yes 0 5 0 1
R:R:L65 R:R:N66 2.75 1 No No 4 5 2 1
R:R:L65 R:R:L81 5.54 1 No No 4 2 2 2
R:R:L81 R:R:N66 5.49 1 No No 2 5 2 1
L:L:?1 R:R:N66 2.71 1 Yes No 0 5 0 1
R:R:E262 R:R:N67 11.83 1 Yes Yes 3 3 1 1
L:L:?1 R:R:N67 2.71 1 Yes Yes 0 3 0 1
L:L:?1 R:R:T82 2.91 1 Yes No 0 1 0 1
R:R:N89 R:R:W85 7.91 1 Yes Yes 8 5 2 1
R:R:I243 R:R:W85 5.87 0 No Yes 3 5 2 1
L:L:?1 R:R:W85 21.72 1 Yes Yes 0 5 0 1
R:R:E86 R:R:I90 2.73 1 Yes No 4 6 1 2
R:R:E86 R:R:I141 2.73 1 Yes No 4 5 1 2
R:R:E86 R:R:H181 14.77 1 Yes No 4 2 1 1
L:L:?1 R:R:E86 5.23 1 Yes Yes 0 4 0 1
R:R:I141 R:R:S144 3.1 0 No No 5 3 2 2
R:R:H181 R:R:S144 6.97 1 No No 2 3 1 2
R:R:F178 R:R:I247 2.51 0 No No 4 4 2 1
L:L:?1 R:R:H181 4.23 1 Yes No 0 2 0 1
R:R:I245 R:R:W261 5.87 0 No Yes 5 4 2 1
R:R:T246 R:R:W261 10.92 1 No Yes 4 4 1 1
L:L:?1 R:R:T246 7.76 1 Yes No 0 4 0 1
L:L:?1 R:R:I247 5.63 1 Yes No 0 4 0 1
R:R:F252 R:R:K254 7.44 0 No No 2 3 2 1
R:R:F252 R:R:W261 28.06 0 No Yes 2 4 2 1
R:R:K254 R:R:L258 4.23 0 No No 3 2 1 2
L:L:?1 R:R:K254 6.49 1 Yes No 0 3 0 1
R:R:E262 R:R:L258 2.65 1 Yes No 3 2 1 2
R:R:V265 R:R:W261 4.9 0 Yes Yes 4 4 2 1
L:L:?1 R:R:W261 3 1 Yes Yes 0 4 0 1
R:R:E262 R:R:Y266 3.37 1 Yes Yes 3 4 1 2
L:L:?1 R:R:E262 8.72 1 Yes Yes 0 3 0 1
R:R:V265 R:R:Y266 5.05 0 Yes Yes 4 4 2 2
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub6.00
Average Interaction Strength6.34
Average Nodes In Shell28.00
Average Hubs In Shell11.00
Average Links In Shell41.00
Average Links Mediated by Hubs In Shell33.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub6.12
Average Interaction Strength8.93
Average Nodes In Shell27.12
Average Hubs In Shell13.75
Average Links In Shell40.25
Average Links Mediated by Hubs In Shell36.88

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)