psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I19	R:R:L70	8.56	No	No	0	7	8
2	R:R:I19	R:R:W413	5.87	No	No	0	7	9
3	R:R:I23	R:R:I66	5.89	No	No	0	8	8
4	R:R:F25	R:R:S420	3.96	No	No	0	5	8
5	R:R:S420	R:R:T26	4.8	No	No	0	8	9
6	R:R:G29	R:R:P423	4.06	No	No	0	9	9
7	R:R:A55	R:R:N30	4.69	No	Yes	0	9	9
8	R:R:D58	R:R:N30	12.12	Yes	Yes	0	9	9
9	R:R:I59	R:R:N30	4.25	No	Yes	0	8	9
10	R:R:N30	R:R:P423	8.15	Yes	No	0	9	9
11	R:R:F437	R:R:L32	10.96	Yes	Yes	0	9	9
12	R:R:I440	R:R:L32	4.28	No	Yes	0	8	9
13	R:R:L32	R:R:L441	4.15	Yes	No	0	9	9
14	R:R:L35	R:R:T39	4.42	No	No	0	6	8
15	R:R:I440	R:R:L35	4.28	No	No	0	8	6
16	R:R:V37	R:R:V52	4.81	No	No	0	9	8
17	R:R:L43	R:R:S40	9.01	No	No	0	9	8
18	R:R:D432	R:R:S42	5.89	No	No	0	9	7
19	R:R:F433	R:R:L43	12.18	Yes	No	0	9	9
20	R:R:A45	R:R:Q47	4.55	No	Yes	0	8	9
21	R:R:P46	R:R:Q47	4.74	No	Yes	0	8	9
22	R:R:P126	R:R:P46	7.79	No	No	0	7	8
23	R:R:D109	R:R:Q47	3.92	Yes	Yes	2	9	9
24	R:R:Q47	R:R:R124	18.69	Yes	Yes	2	9	8
25	R:R:F433	R:R:N48	4.83	Yes	No	0	9	9
26	R:R:A105	R:R:F50	4.16	No	Yes	0	8	9
27	R:R:F50	R:R:I106	5.02	Yes	No	0	9	9
28	R:R:D109	R:R:F50	4.78	Yes	Yes	0	9	9
29	R:R:F50	R:R:I129	10.05	Yes	No	0	9	9
30	R:R:F50	R:R:I132	6.28	Yes	No	0	9	7
31	R:R:H102	R:R:S53	5.58	Yes	No	5	9	9
32	R:R:I133	R:R:S53	10.84	No	No	5	9	9
33	R:R:H102	R:R:L54	3.86	Yes	No	0	9	9
34	R:R:L54	R:R:N422	4.12	No	Yes	0	9	9
35	R:R:D58	R:R:S99	4.42	Yes	No	0	9	9
36	R:R:D58	R:R:S419	10.31	Yes	No	0	9	9
37	R:R:D58	R:R:N422	6.73	Yes	Yes	0	9	9
38	R:R:F95	R:R:L60	13.4	No	No	0	8	8
39	R:R:S419	R:R:V61	6.46	No	No	0	9	9
40	R:R:I65	R:R:Y88	8.46	No	Yes	0	9	8
41	R:R:D92	R:R:I65	12.59	No	No	0	9	9
42	R:R:I66	R:R:Y416	7.25	No	Yes	0	8	8
43	R:R:F68	R:R:Y88	8.25	No	Yes	0	7	8
44	R:R:S69	R:R:Y88	6.36	No	Yes	0	8	8
45	R:R:S69	R:R:Y416	5.09	No	Yes	0	8	8
46	R:R:L70	R:R:L74	5.54	No	No	0	8	8
47	R:R:E73	R:R:Q409	7.65	No	No	0	8	5
48	R:R:E73	R:R:W413	7.63	No	No	0	8	9
49	R:R:C85	R:R:W78	6.53	No	Yes	6	9	9
50	R:R:C164	R:R:W78	13.06	No	Yes	6	9	9
51	R:R:C164	R:R:C85	5.46	No	No	6	9	9
52	R:R:F95	R:R:L91	4.87	No	No	0	8	7
53	R:R:D92	R:R:Y416	6.9	No	Yes	1	9	8
54	L:L:?1	R:R:D92	9.97	Yes	No	1	0	9
55	L:L:?1	R:R:V93	9.73	Yes	No	0	0	9
56	R:R:L94	R:R:S144	6.01	No	No	0	8	9
57	R:R:F95	R:R:W137	4.01	No	Yes	0	8	9
58	R:R:C96	R:R:W384	5.22	No	Yes	1	9	9
59	L:L:?1	R:R:C96	6.48	Yes	No	1	0	9
60	R:R:I143	R:R:T97	6.08	No	No	0	8	9
61	R:R:S180	R:R:T97	7.99	No	No	0	9	9
62	R:R:S98	R:R:W137	14.83	No	Yes	0	9	9
63	R:R:F380	R:R:I100	5.02	Yes	No	1	9	9
64	R:R:I100	R:R:W384	12.92	No	Yes	1	9	9
65	R:R:V101	R:R:V136	6.41	No	No	0	8	9
66	R:R:H102	R:R:I133	3.98	Yes	No	5	9	9
67	R:R:H102	R:R:V136	6.92	Yes	No	0	9	9
68	R:R:H102	R:R:W137	7.41	Yes	Yes	0	9	9
69	R:R:L103	R:R:N422	6.87	No	Yes	0	9	9
70	R:R:L103	R:R:Y426	7.03	No	Yes	0	9	9
71	R:R:I106	R:R:R110	5.01	No	No	4	9	9
72	R:R:I106	R:R:Y426	4.84	No	Yes	4	9	9
73	R:R:M188	R:R:S107	4.6	No	No	0	9	9
74	R:R:S107	R:R:V191	4.85	No	No	0	9	9
75	R:R:S107	R:R:Y192	13.99	No	Yes	0	9	9
76	R:R:L108	R:R:W112	10.25	No	Yes	0	7	7
77	R:R:D109	R:R:Y120	9.2	Yes	Yes	2	9	9
78	R:R:D109	R:R:R124	13.1	Yes	Yes	2	9	8
79	R:R:R110	R:R:Y192	4.12	No	Yes	0	9	9
80	R:R:R110	R:R:Y426	7.2	No	Yes	4	9	9
81	R:R:W112	R:R:Y111	5.79	Yes	Yes	0	7	9
82	R:R:S115	R:R:Y111	12.72	No	Yes	0	9	9
83	R:R:V191	R:R:Y111	5.05	No	Yes	0	9	9
84	R:R:R194	R:R:Y111	11.32	No	Yes	0	7	9
85	R:R:R116	R:R:W112	13.99	No	Yes	2	7	7
86	R:R:W112	R:R:Y120	9.65	Yes	Yes	2	7	9
87	R:R:R128	R:R:W112	5	No	Yes	2	8	7
88	R:R:A113	R:R:R124	5.53	No	Yes	0	9	8
89	R:R:I198	R:R:V114	4.61	No	No	0	8	9
90	R:R:E119	R:R:R116	9.3	No	No	0	6	7
91	R:R:R116	R:R:Y120	8.23	No	Yes	2	7	9
92	R:R:R124	R:R:Y120	14.4	Yes	Yes	2	8	9
93	R:R:R128	R:R:Y120	6.17	No	Yes	2	8	9
94	R:R:P146	R:R:P147	5.84	No	No	7	8	8
95	R:R:P146	R:R:Y172	6.95	No	Yes	7	8	8
96	R:R:P147	R:R:Y172	12.52	No	Yes	7	8	8
97	R:R:I173	R:R:N167	5.66	No	No	0	8	8
98	R:R:W171	R:R:Y172	5.79	No	Yes	0	5	8
99	R:R:S176	R:R:Y172	11.45	No	Yes	0	9	8
100	R:R:I173	R:R:Y391	15.71	No	Yes	0	8	8
101	R:R:S176	R:R:Y391	3.82	No	Yes	0	9	8
102	R:R:F182	R:R:S177	5.28	No	Yes	1	8	8
103	R:R:F388	R:R:S177	3.96	Yes	Yes	1	9	8
104	R:R:S177	R:R:Y391	3.82	Yes	Yes	1	8	8
105	R:R:S177	R:R:S392	4.89	Yes	No	1	8	8
106	L:L:?1	R:R:S180	6.13	Yes	No	0	0	9
107	R:R:F181	R:R:F182	6.43	Yes	No	1	9	8
108	R:R:C185	R:R:F181	11.17	No	Yes	1	8	9
109	R:R:F181	R:R:F380	7.5	Yes	Yes	1	9	9
110	R:R:F181	R:R:F385	7.5	Yes	Yes	0	9	8
111	R:R:F181	R:R:F388	17.15	Yes	Yes	1	9	9
112	R:R:F182	R:R:S392	3.96	No	No	1	8	8
113	R:R:C185	R:R:F380	5.59	No	Yes	1	8	9
114	R:R:F380	R:R:M188	4.98	Yes	No	0	9	9
115	R:R:I189	R:R:I377	5.89	No	No	0	6	8
116	R:R:I195	R:R:Y192	4.84	No	Yes	0	9	9
117	R:R:V376	R:R:Y192	5.05	No	Yes	0	9	9
118	R:R:K200	R:R:Y196	5.97	No	Yes	0	7	8
119	R:R:F369	R:R:Y196	5.16	Yes	Yes	0	9	8
120	R:R:I198	R:R:R201	6.26	No	No	0	8	6
121	R:R:A199	R:R:F369	8.32	No	Yes	0	9	9
122	R:R:N203	R:R:Q362	7.92	No	No	0	5	5
123	R:R:N203	R:R:R365	12.05	No	No	0	5	8
124	R:R:F369	R:R:N203	4.83	Yes	No	0	9	5
125	R:R:E366	R:R:F369	7	No	Yes	0	9	9
126	R:R:R368	R:R:V372	3.92	No	No	8	9	9
127	R:R:F429	R:R:R368	7.48	No	No	8	8	9
128	R:R:F371	R:R:V375	5.24	No	No	0	7	9
129	R:R:F429	R:R:V372	6.55	No	No	8	8	9
130	R:R:I425	R:R:V379	4.61	No	No	0	9	8
131	R:R:F380	R:R:W384	5.01	Yes	Yes	1	9	9
132	R:R:F380	R:R:N418	4.83	Yes	Yes	1	9	9
133	R:R:C383	R:R:N418	9.45	No	Yes	0	9	9
134	R:R:F388	R:R:W384	8.02	Yes	Yes	1	9	9
135	R:R:G415	R:R:W384	8.44	No	Yes	0	9	9
136	R:R:N418	R:R:W384	10.17	Yes	Yes	1	9	9
137	L:L:?1	R:R:W384	5.58	Yes	Yes	1	0	9
138	R:R:F385	R:R:P386	4.33	Yes	No	0	8	9
139	R:R:F411	R:R:P386	13	Yes	No	0	7	9
140	R:R:F387	R:R:F388	6.43	Yes	Yes	1	9	9
141	R:R:F387	R:R:Y391	8.25	Yes	Yes	1	9	8
142	R:R:F387	R:R:F408	6.43	Yes	No	0	9	7
143	L:L:?1	R:R:F387	17.89	Yes	Yes	1	0	9
144	L:L:?1	R:R:F388	5.96	Yes	Yes	1	0	9
145	R:R:F411	R:R:S390	3.96	Yes	No	0	7	8
146	L:L:?1	R:R:Y391	6.7	Yes	Yes	1	0	8
147	R:R:F410	R:R:F411	4.29	No	Yes	0	7	7
148	R:R:F410	R:R:I414	10.05	No	No	0	7	9
149	R:R:F412	R:R:Y416	9.28	No	Yes	1	8	8
150	L:L:?1	R:R:F412	17.89	Yes	No	1	0	8
151	R:R:W413	R:R:Y416	5.79	No	Yes	0	9	8
152	L:L:?1	R:R:Y416	8.61	Yes	Yes	1	0	8
153	R:R:N418	R:R:N422	10.9	Yes	Yes	0	9	9
154	R:R:I425	R:R:Y426	7.25	No	Yes	0	9	9
155	R:R:F433	R:R:T427	14.27	Yes	No	3	9	9
156	R:R:F437	R:R:T427	7.78	Yes	No	3	9	9
157	R:R:F429	R:R:I428	5.02	No	No	0	8	7
158	R:R:D432	R:R:N430	6.73	No	No	0	9	9
159	R:R:F433	R:R:N430	8.46	Yes	No	0	9	9
160	R:R:D432	R:R:Q431	5.22	No	No	0	9	4
161	R:R:Q431	R:R:R435	7.01	No	No	0	4	6
162	R:R:F433	R:R:F437	4.29	Yes	Yes	3	9	9
163	R:R:R435	R:R:R438	7.46	No	No	0	6	7
164	R:R:C104	R:R:P184	3.77	No	No	0	8	9
165	R:R:T370	R:R:Y196	3.75	No	Yes	0	9	8
166	R:R:H405	R:R:Q409	3.71	No	No	0	5	5
167	R:R:F411	R:R:L407	3.65	Yes	No	0	7	7
168	R:R:G179	R:R:I178	3.53	No	No	0	7	7
169	R:R:L51	R:R:Y426	3.52	No	Yes	0	8	9
170	R:R:L75	R:R:Y77	3.52	No	No	0	6	4
171	R:R:L166	R:R:Y391	3.52	No	Yes	0	7	8
172	R:R:L373	R:R:Y192	3.52	No	Yes	0	9	9
173	R:R:L373	R:R:Y196	3.52	No	Yes	0	9	8
174	R:R:P126	R:R:T125	3.5	No	No	0	7	9
175	R:R:A140	R:R:S98	3.42	No	No	0	9	9
176	R:R:I23	R:R:P67	3.39	No	No	0	8	9
177	R:R:A55	R:R:V33	3.39	No	No	0	9	9
178	R:R:N72	R:R:W78	3.39	No	Yes	0	7	9
179	R:R:A62	R:R:T26	3.36	No	No	0	9	9
180	R:R:C104	R:R:I187	3.27	No	No	0	8	8
181	R:R:C185	R:R:I189	3.27	No	No	0	8	6
182	R:R:A55	R:R:I34	3.25	No	No	0	9	8
183	R:R:F385	R:R:F389	3.22	Yes	No	0	8	8
184	R:R:T427	R:R:V33	3.17	No	No	0	9	9
185	R:R:I27	R:R:T63	3.04	No	No	0	7	6
186	R:R:I59	R:R:T63	3.04	No	No	0	8	6
187	R:R:L22	R:R:S420	3	No	No	0	8	8
188	R:R:L421	R:R:V379	2.98	No	No	0	7	8
189	R:R:N48	R:R:V37	2.96	No	No	0	9	9
190	R:R:N30	R:R:T26	2.92	Yes	No	0	9	9
191	R:R:W78	R:R:Y88	2.89	Yes	Yes	0	9	8
192	R:R:I34	R:R:L38	2.85	No	No	0	8	6
193	R:R:I129	R:R:L49	2.85	No	No	0	9	8
194	R:R:K130	R:R:L49	2.82	No	No	0	6	8
195	R:R:A36	R:R:F437	2.77	No	Yes	0	9	9
196	R:R:E119	R:R:K123	2.7	No	No	0	6	6
197	R:R:E86	R:R:L148	2.65	No	No	0	8	9
198	R:R:F385	R:R:V381	2.62	Yes	No	0	8	8
199	R:R:A57	R:R:W137	2.59	No	Yes	0	9	9
200	R:R:F28	R:R:L32	2.44	No	Yes	0	6	9
201	R:R:F389	R:R:L393	2.44	No	No	0	8	7
202	R:R:L89	R:R:Y88	2.34	No	Yes	0	8	8
203	R:R:A183	R:R:P184	1.87	No	No	0	7	9
204	R:R:A36	R:R:A436	1.79	No	No	0	9	9
205	R:R:P184	R:R:V101	1.77	No	No	0	9	8
206	R:R:G378	R:R:I377	1.76	No	No	0	8	8
207	R:R:A141	R:R:S144	1.71	No	No	0	7	9
208	R:R:G76	R:R:N72	1.7	No	No	0	8	7
209	R:R:L145	R:R:P146	1.64	No	No	0	7	8
210	R:R:L407	R:R:P404	1.64	No	No	0	7	8
211	R:R:C417	R:R:I414	1.64	No	No	0	7	9
212	R:R:V372	R:R:V376	1.6	No	No	0	9	9
213	R:R:V375	R:R:V379	1.6	No	No	0	9	8
214	R:R:A16	R:R:L74	1.58	No	No	0	7	8
215	R:R:A90	R:R:L148	1.58	No	No	0	9	9
216	R:R:A140	R:R:L94	1.58	No	No	0	9	8
217	R:R:I198	R:R:S115	1.55	No	No	0	8	9
218	R:R:I428	R:R:V424	1.54	No	No	0	7	7
219	R:R:I139	R:R:T135	1.52	No	No	0	7	5
220	R:R:L91	R:R:V87	1.49	No	No	0	7	7
221	R:R:I15	R:R:I19	1.47	No	No	0	8	7
222	R:R:L24	R:R:T20	1.47	No	No	0	5	6
223	R:R:L64	R:R:T63	1.47	No	No	0	6	6
224	R:R:I149	R:R:L145	1.43	No	No	0	6	7
225	R:R:I178	R:R:L174	1.43	No	No	0	7	7
226	R:R:I189	R:R:L193	1.43	No	No	0	6	4
227	R:R:R127	R:R:T125	1.29	No	No	0	6	9
228	R:R:L197	R:R:Y196	1.17	No	Yes	0	5	8
229	R:R:R438	R:R:R439	1.07	No	No	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N30	6.426	5	0	9
2	R:R:L32	5.4575	4	0	9
3	R:R:Q47	7.975	4	2	9
4	R:R:F50	6.058	5	0	9
5	R:R:D58	8.395	4	0	9
6	R:R:W78	6.4675	4	6	9
7	R:R:Y88	5.66	5	0	8
8	R:R:H102	5.55	5	5	9
9	R:R:D109	7.75	4	2	9
10	R:R:Y111	8.72	4	0	9
11	R:R:W112	8.936	5	2	7
12	R:R:Y120	9.53	5	2	9
13	R:R:R124	12.93	4	2	8
14	R:R:W137	7.21	4	0	9
15	R:R:Y172	9.1775	4	7	8
16	R:R:S177	4.4875	4	1	8
17	R:R:F181	9.95	5	1	9
18	R:R:Y192	6.304	5	0	9
19	R:R:Y196	3.914	5	0	8
20	R:R:F369	6.3275	4	0	9
21	R:R:F380	5.48833	6	1	9
22	R:R:W384	7.90857	7	1	9
23	R:R:F385	4.4175	4	0	8
24	R:R:F387	9.75	4	1	9
25	R:R:F388	8.304	5	1	9
26	R:R:Y391	6.97	6	1	8
27	R:R:F411	6.225	4	0	7
28	R:R:Y416	7.15333	6	1	8
29	R:R:N418	8.8375	4	1	9
30	R:R:N422	7.155	4	0	9
31	R:R:Y426	5.968	5	4	9
32	R:R:F433	8.806	5	3	9
33	R:R:F437	6.45	4	3	9
34	L:L:?1	9.494	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I19	R:R:W413	11.9006	5.87	No	No	0	7	9
2	R:R:W413	R:R:Y416	20.9441	5.79	No	Yes	0	9	8
3	R:R:N30	R:R:T26	12.7826	2.92	Yes	No	0	9	9
4	R:R:D58	R:R:N30	82.323	12.12	Yes	Yes	0	9	9
5	R:R:D58	R:R:N422	88.7329	6.73	Yes	Yes	0	9	9
6	R:R:N418	R:R:N422	100	10.9	Yes	Yes	0	9	9
7	R:R:N418	R:R:W384	66.7453	10.17	Yes	Yes	1	9	9
8	L:L:?1	R:R:W384	84.3354	5.58	Yes	Yes	1	0	9
9	L:L:?1	R:R:Y416	48.1118	8.61	Yes	Yes	1	0	8
10	R:R:A55	R:R:N30	60.7081	4.69	No	Yes	0	9	9
11	R:R:I59	R:R:N30	10.2733	4.25	No	Yes	0	8	9
12	R:R:A55	R:R:V33	54.7453	3.39	No	No	0	9	9
13	R:R:T427	R:R:V33	52.6584	3.17	No	No	0	9	9
14	R:R:F437	R:R:T427	20.646	7.78	Yes	No	3	9	9
15	R:R:F437	R:R:L32	15.1925	10.96	Yes	Yes	0	9	9
16	R:R:F433	R:R:T427	30.1615	14.27	Yes	No	3	9	9
17	R:R:D432	R:R:N430	15.2671	6.73	No	No	0	9	9
18	R:R:F433	R:R:N430	17.7267	8.46	Yes	No	0	9	9
19	R:R:D109	R:R:Q47	18.3106	3.92	Yes	Yes	2	9	9
20	R:R:D109	R:R:F50	28.8944	4.78	Yes	Yes	0	9	9
21	R:R:F50	R:R:I106	41.8261	5.02	Yes	No	0	9	9
22	R:R:I106	R:R:Y426	35.8137	4.84	No	Yes	4	9	9
23	R:R:L103	R:R:Y426	63.7019	7.03	No	Yes	0	9	9
24	R:R:L103	R:R:N422	64.9565	6.87	No	Yes	0	9	9
25	R:R:P46	R:R:Q47	14.3478	4.74	No	Yes	0	8	9
26	R:R:P126	R:R:P46	10.795	7.79	No	No	0	7	8
27	R:R:H102	R:R:L54	47.0559	3.86	Yes	No	0	9	9
28	R:R:L54	R:R:N422	49.1677	4.12	No	Yes	0	9	9
29	R:R:H102	R:R:W137	26.9317	7.41	Yes	Yes	0	9	9
30	R:R:S69	R:R:Y88	19.3789	6.36	No	Yes	0	8	8
31	R:R:S69	R:R:Y416	21.4037	5.09	No	Yes	0	8	8
32	R:R:W78	R:R:Y88	23.7516	2.89	Yes	Yes	0	9	8
33	R:R:S98	R:R:W137	12.7826	14.83	No	Yes	0	9	9
34	R:R:A140	R:R:S98	10.2733	3.42	No	No	0	9	9
35	R:R:F380	R:R:W384	29.8509	5.01	Yes	Yes	1	9	9
36	R:R:H102	R:R:V136	15.2671	6.92	Yes	No	0	9	9
37	R:R:V101	R:R:V136	12.7826	6.41	No	No	0	8	9
38	R:R:F380	R:R:M188	54.8696	4.98	Yes	No	0	9	9
39	R:R:M188	R:R:S107	53.8509	4.6	No	No	0	9	9
40	R:R:S107	R:R:V191	31.7888	4.85	No	No	0	9	9
41	R:R:S107	R:R:Y192	29.1056	13.99	No	Yes	0	9	9
42	R:R:V191	R:R:Y111	29.7516	5.05	No	Yes	0	9	9
43	R:R:W112	R:R:Y111	18.7578	5.79	Yes	Yes	0	7	9
44	R:R:W112	R:R:Y120	11.2671	9.65	Yes	Yes	2	7	9
45	R:R:S115	R:R:Y111	10.2112	12.72	No	Yes	0	9	9
46	L:L:?1	R:R:Y391	27.9255	6.7	Yes	Yes	1	0	8
47	R:R:S176	R:R:Y391	22.7702	3.82	No	Yes	0	9	8
48	R:R:S176	R:R:Y172	19.5901	11.45	No	Yes	0	9	8
49	L:L:?1	R:R:F388	13.6646	5.96	Yes	Yes	1	0	9
50	R:R:F181	R:R:F388	19.7764	17.15	Yes	Yes	1	9	9
51	R:R:C185	R:R:F380	12.9068	5.59	No	Yes	1	8	9
52	R:R:F181	R:R:F385	38.4472	7.5	Yes	Yes	0	9	8
53	R:R:C185	R:R:I189	15.441	3.27	No	No	0	8	6
54	R:R:V376	R:R:Y192	14.4348	5.05	No	Yes	0	9	9
55	R:R:L373	R:R:Y192	26.3478	3.52	No	Yes	0	9	9
56	R:R:L373	R:R:Y196	24.3602	3.52	No	Yes	0	9	8
57	R:R:F369	R:R:Y196	14.9689	5.16	Yes	Yes	0	9	8
58	R:R:V372	R:R:V376	12.1118	1.6	No	No	0	9	9
59	R:R:I425	R:R:Y426	12.472	7.25	No	Yes	0	9	9
60	R:R:F385	R:R:P386	26.0248	4.33	Yes	No	0	8	9
61	R:R:F411	R:R:P386	22.8571	13	Yes	No	0	7	9
62	R:R:D432	R:R:Q431	10.2733	5.22	No	No	0	9	4
63	R:R:P184	R:R:V101	10.2733	1.77	No	No	0	9	8
64	R:R:D92	R:R:I65	20.1491	12.59	No	No	0	9	9
65	R:R:R110	R:R:Y192	26.6335	4.12	No	Yes	0	9	9
66	R:R:R110	R:R:Y426	19.0186	7.2	No	Yes	4	9	9
67	L:L:?1	R:R:D92	21.9503	9.97	Yes	No	1	0	9
68	R:R:I65	R:R:Y88	18.1366	8.46	No	Yes	0	9	8
69	R:R:F380	R:R:N418	33.8882	4.83	Yes	Yes	1	9	9
70	R:R:D109	R:R:Y120	10.7329	9.2	Yes	Yes	2	9	9
71	R:R:F181	R:R:F380	31.6149	7.5	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D92	R:R:I65	12.59	1	No	No	9	9	1	2
R:R:I66	R:R:Y416	7.25	0	No	Yes	8	8	2	1
R:R:S69	R:R:Y416	5.09	0	No	Yes	8	8	2	1
R:R:D92	R:R:Y416	6.9	1	No	Yes	9	8	1	1
L:L:?1	R:R:D92	9.97	1	Yes	No	0	9	0	1
L:L:?1	R:R:V93	9.73	1	Yes	No	0	9	0	1
R:R:C96	R:R:W384	5.22	1	No	Yes	9	9	1	1
L:L:?1	R:R:C96	6.48	1	Yes	No	0	9	0	1
R:R:S180	R:R:T97	7.99	0	No	No	9	9	1	2
R:R:F380	R:R:I100	5.02	1	Yes	No	9	9	2	2
R:R:I100	R:R:W384	12.92	1	No	Yes	9	9	2	1
R:R:I173	R:R:Y391	15.71	0	No	Yes	8	8	2	1
R:R:S176	R:R:Y391	3.82	0	No	Yes	9	8	2	1
R:R:F388	R:R:S177	3.96	1	Yes	Yes	9	8	1	2
R:R:S177	R:R:Y391	3.82	1	Yes	Yes	8	8	2	1
L:L:?1	R:R:S180	6.13	1	Yes	No	0	9	0	1
R:R:F181	R:R:F380	7.5	1	Yes	Yes	9	9	2	2
R:R:F181	R:R:F388	17.15	1	Yes	Yes	9	9	2	1
R:R:F380	R:R:W384	5.01	1	Yes	Yes	9	9	2	1
R:R:F380	R:R:N418	4.83	1	Yes	Yes	9	9	2	2
R:R:F388	R:R:W384	8.02	1	Yes	Yes	9	9	1	1
R:R:G415	R:R:W384	8.44	0	No	Yes	9	9	2	1
R:R:N418	R:R:W384	10.17	1	Yes	Yes	9	9	2	1
L:L:?1	R:R:W384	5.58	1	Yes	Yes	0	9	0	1
R:R:F387	R:R:F388	6.43	1	Yes	Yes	9	9	1	1
R:R:F387	R:R:Y391	8.25	1	Yes	Yes	9	8	1	1
R:R:F387	R:R:F408	6.43	1	Yes	No	9	7	1	2
L:L:?1	R:R:F387	17.89	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F388	5.96	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y391	6.7	1	Yes	Yes	0	8	0	1
R:R:F412	R:R:Y416	9.28	1	No	Yes	8	8	1	1
L:L:?1	R:R:F412	17.89	1	Yes	No	0	8	0	1
R:R:W413	R:R:Y416	5.79	0	No	Yes	9	8	2	1
L:L:?1	R:R:Y416	8.61	1	Yes	Yes	0	8	0	1
R:R:L166	R:R:Y391	3.52	0	No	Yes	7	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6K41_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.82
Number of Linked Nodes	209
Number of Links	229
Number of Hubs	34
Number of Links mediated by Hubs	131
Number of Communities	8
Number of Nodes involved in Communities	42
Number of Links involved in Communities	57

Path Summary
Number Of Nodes in MetaPath	72
Number Of Links MetaPath	71
Number of Shortest Paths	22577
Length Of Smallest Path	3
Average Path Length	10.7303
Length of Longest Path	23
Minimum Path Strength	1.535
Average Path Strength	6.64708
Maximum Path Strength	17.89
Minimum Path Correlation	0.7
Average Path Correlation	0.899589
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	45.9895
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.52
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • GABA-ergic synapse • glutamatergic synapse • cell body • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • response to external stimulus • detection of abiotic stimulus • detection of stimulus • response to radiation • phototransduction, visible light • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • myelin sheath • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • G-protein beta-subunit binding • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • alpha-adrenergic receptor activity • G protein-coupled amine receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • adrenergic receptor activity • alpha2-adrenergic receptor activity • epinephrine binding • cation binding • ion binding • catecholamine binding • hormone binding • small molecule binding • protein heterodimerization activity • protein dimerization activity • heterotrimeric G-protein binding • thioesterase binding • identical protein binding • protein homodimerization activity • kinase binding • protein kinase binding • adrenergic receptor binding • signaling receptor binding • alpha-2C adrenergic receptor binding • G protein-coupled receptor binding • norepinephrine binding • regulation of body fluid levels • wound healing • cell activation • hemostasis • blood coagulation • coagulation • regulation of biological quality • response to wounding • platelet activation • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • positive regulation of signaling • cellular developmental process • regulation of developmental process • regulation of cell differentiation • positive regulation of neuron differentiation • positive regulation of developmental process • neurogenesis • neuron differentiation • positive regulation of cell differentiation • cell differentiation • nervous system development • generation of neurons • regulation of neuron differentiation • adrenergic receptor signaling pathway • multi-multicellular organism process • reproductive process • female pregnancy • multi-organism reproductive process • monoamine transport • regulation of localization • nitrogen compound transport • negative regulation of amine transport • transport • regulation of catecholamine secretion • negative regulation of biological process • epinephrine secretion • negative regulation of transport • organic hydroxy compound transport • localization • secretion by cell • regulation of secretion by cell • negative regulation of secretion • catecholamine transport • negative regulation of cellular process • negative regulation of secretion by cell • epinephrine transport • regulation of epinephrine secretion • secretion • regulation of transport • export from cell • negative regulation of catecholamine secretion • establishment of localization • organic cation transport • regulation of secretion • catecholamine secretion • amine transport • negative regulation of epinephrine secretion • regulation of amine transport • circulatory system process • regulation of blood pressure • positive regulation of blood pressure • blood circulation • positive regulation of smooth muscle contraction • positive regulation of uterine smooth muscle contraction • regulation of system process • muscle contraction • muscle system process • regulation of muscle system process • uterine smooth muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • positive regulation of muscle contraction • regulation of uterine smooth muscle contraction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • cell-cell signaling • vascular associated smooth muscle contraction • regulation of vascular associated smooth muscle contraction • blood vessel diameter maintenance • regulation of tube diameter • regulation of tube size • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • vasoconstriction • regulation of anatomical structure size • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • signal release • negative regulation of norepinephrine secretion • norepinephrine transport • norepinephrine secretion • regulation of norepinephrine secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • positive regulation of response to wounding • regulation of response to wounding • positive regulation of wound healing • regulation of response to stress • regulation of wound healing • phospholipase C-activating adrenergic receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting adrenergic receptor signaling pathway • cell surface receptor protein tyrosine kinase signaling pathway • positive regulation of ERBB signaling pathway • regulation of epidermal growth factor receptor signaling pathway • epidermal growth factor receptor signaling pathway • enzyme-linked receptor protein signaling pathway • positive regulation of epidermal growth factor receptor signaling pathway • regulation of ERBB signaling pathway • cell surface receptor signaling pathway • ERBB signaling pathway • fear response • multicellular organismal response to stress • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of protein transport • establishment of protein localization • carbohydrate homeostasis • establishment of localization in cell • negative regulation of hormone secretion • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • intracellular glucose homeostasis • protein secretion • regulation of protein secretion • cellular response to carbohydrate stimulus • chemical homeostasis • negative regulation of protein secretion • response to glucose • glucose homeostasis • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • homeostatic process • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • response to monosaccharide • response to carbohydrate • amide transport • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • negative regulation of protein localization • negative regulation of response to stimulus • regulation of peptide transport • negative regulation of insulin secretion involved in cellular response to glucose stimulus • regulation of establishment of protein localization • cellular response to glucose stimulus • regulation of protein transport • peptide transport • response to hexose • cellular homeostasis • negative regulation of insulin secretion • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • insulin secretion • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • cytokine production • regulation of cytokine production • positive regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • positive regulation of gene expression • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process • positive regulation of protein metabolic process • positive regulation of membrane protein ectodomain proteolysis • macromolecule catabolic process • regulation of proteolysis • proteolysis • membrane protein proteolysis • protein metabolic process • membrane protein ectodomain proteolysis • regulation of membrane protein ectodomain proteolysis • regulation of protein metabolic process • protein catabolic process • positive regulation of protein catabolic process • positive regulation of catabolic process • positive regulation of proteolysis • regulation of protein catabolic process • cell surface • cytosol • intracellular organelle • intracellular membrane-bounded organelle • dopaminergic synapse • receptor complex
SCOP2	Domain Identifier	• WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CZX
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	CZX
Name	Dexmedetomidine
Synonyms	Dexmedetomidinum
Identifier
Formula	C13 H16 N2
Molecular Weight	200.28
SMILES
PubChem	5311068
Formal Charge	0
Total Atoms	31
Total Chiral Atoms	1
Total Bonds	32
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P18089
Sequence	>6K41_nogp_Chain_R A T A A I A A A I T F L I L F T I F G N A L V I L A V L T S R S L R A P Q N L F L V S L A A A D I L V A T L I I P F S L A N E L L G Y W C E V Y L A L D V L F C T S S I V H L C A I S L D R Y W A V S R A L E Y N S K R T P R R I K C I I L T V W L I A A V I S L P P L I C K L N A W Y I L A S S I G S F F A P C L I M I L V Y L R I Y L I A K R S N A Q L T R E K R F T F V L A V V I G V F V L C W F P F F F S Y S L P H G L F Q F F F W I G Y C N S S L N P V I Y T I F N Q D F R R A F R R I L C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6K41	A	Amine	Adrenergic	α_2b	Homo sapiens	Dexmedetomidine	-	Go/β1/γ2	2.9	2020-04-15	doi.org/10.1038/s41589-020-0492-2
	6K41 (No Gprot)	A	Amine	Adrenergic	α_2b	Homo sapiens	Dexmedetomidine	-		2.9	2020-04-15	doi.org/10.1038/s41589-020-0492-2
	6K42	A	Amine	Adrenergic	α_2b	Homo sapiens	Dexmedetomidine	-	Gi1/β1/γ2	4.1	2020-04-15	doi.org/10.1038/s41589-020-0492-2
	6K42 (No Gprot)	A	Amine	Adrenergic	α_2b	Homo sapiens	Dexmedetomidine	-		4.1	2020-04-15	doi.org/10.1038/s41589-020-0492-2

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