psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I19	R:R:L70	8.56	No	No	0	7	8
2	R:R:I19	R:R:W413	5.87	No	No	0	7	9
3	R:R:I23	R:R:I66	5.89	No	No	0	8	8
4	R:R:F25	R:R:S420	3.96	No	No	0	5	8
5	R:R:S420	R:R:T26	4.8	No	No	0	8	9
6	R:R:G29	R:R:P423	4.06	No	No	0	9	9
7	R:R:A55	R:R:N30	4.69	No	Yes	0	9	9
8	R:R:D58	R:R:N30	12.12	Yes	Yes	0	9	9
9	R:R:I59	R:R:N30	4.25	No	Yes	0	8	9
10	R:R:N30	R:R:P423	8.15	Yes	No	0	9	9
11	R:R:F437	R:R:L32	10.96	Yes	Yes	0	9	9
12	R:R:I440	R:R:L32	4.28	No	Yes	0	8	9
13	R:R:L32	R:R:L441	4.15	Yes	No	0	9	9
14	R:R:L35	R:R:T39	4.42	No	No	0	6	8
15	R:R:I440	R:R:L35	4.28	No	No	0	8	6
16	R:R:V37	R:R:V52	4.81	No	No	0	9	8
17	R:R:L43	R:R:S40	9.01	No	No	0	9	8
18	R:R:D432	R:R:S42	5.89	No	No	0	9	7
19	R:R:F433	R:R:L43	12.18	Yes	No	0	9	9
20	R:R:A45	R:R:Q47	4.55	No	Yes	0	8	9
21	R:R:P46	R:R:Q47	4.74	No	Yes	0	8	9
22	R:R:P126	R:R:P46	7.79	No	No	0	7	8
23	R:R:D109	R:R:Q47	3.92	Yes	Yes	2	9	9
24	R:R:Q47	R:R:R124	18.69	Yes	Yes	2	9	8
25	R:R:F433	R:R:N48	4.83	Yes	No	0	9	9
26	R:R:A105	R:R:F50	4.16	No	Yes	0	8	9
27	R:R:F50	R:R:I106	5.02	Yes	No	0	9	9
28	R:R:D109	R:R:F50	4.78	Yes	Yes	0	9	9
29	R:R:F50	R:R:I129	10.05	Yes	No	0	9	9
30	R:R:F50	R:R:I132	6.28	Yes	No	0	9	7
31	R:R:H102	R:R:S53	5.58	Yes	No	5	9	9
32	R:R:I133	R:R:S53	10.84	No	No	5	9	9
33	R:R:H102	R:R:L54	3.86	Yes	No	0	9	9
34	R:R:L54	R:R:N422	4.12	No	Yes	0	9	9
35	R:R:D58	R:R:S99	4.42	Yes	No	0	9	9
36	R:R:D58	R:R:S419	10.31	Yes	No	0	9	9
37	R:R:D58	R:R:N422	6.73	Yes	Yes	0	9	9
38	R:R:F95	R:R:L60	13.4	No	No	0	8	8
39	R:R:S419	R:R:V61	6.46	No	No	0	9	9
40	R:R:I65	R:R:Y88	8.46	No	Yes	0	9	8
41	R:R:D92	R:R:I65	12.59	No	No	0	9	9
42	R:R:I66	R:R:Y416	7.25	No	Yes	0	8	8
43	R:R:F68	R:R:Y88	8.25	No	Yes	0	7	8
44	R:R:S69	R:R:Y88	6.36	No	Yes	0	8	8
45	R:R:S69	R:R:Y416	5.09	No	Yes	0	8	8
46	R:R:L70	R:R:L74	5.54	No	No	0	8	8
47	R:R:E73	R:R:Q409	7.65	No	No	0	8	5
48	R:R:E73	R:R:W413	7.63	No	No	0	8	9
49	R:R:C85	R:R:W78	6.53	No	Yes	6	9	9
50	R:R:C164	R:R:W78	13.06	No	Yes	6	9	9
51	R:R:C164	R:R:C85	5.46	No	No	6	9	9
52	R:R:F95	R:R:L91	4.87	No	No	0	8	7
53	R:R:D92	R:R:Y416	6.9	No	Yes	1	9	8
54	L:L:?1	R:R:D92	9.97	Yes	No	1	0	9
55	L:L:?1	R:R:V93	9.73	Yes	No	0	0	9
56	R:R:L94	R:R:S144	6.01	No	No	0	8	9
57	R:R:F95	R:R:W137	4.01	No	Yes	0	8	9
58	R:R:C96	R:R:W384	5.22	No	Yes	1	9	9
59	L:L:?1	R:R:C96	6.48	Yes	No	1	0	9
60	R:R:I143	R:R:T97	6.08	No	No	0	8	9
61	R:R:S180	R:R:T97	7.99	No	No	0	9	9
62	R:R:S98	R:R:W137	14.83	No	Yes	0	9	9
63	R:R:F380	R:R:I100	5.02	Yes	No	1	9	9
64	R:R:I100	R:R:W384	12.92	No	Yes	1	9	9
65	R:R:V101	R:R:V136	6.41	No	No	0	8	9
66	R:R:H102	R:R:I133	3.98	Yes	No	5	9	9
67	R:R:H102	R:R:V136	6.92	Yes	No	0	9	9
68	R:R:H102	R:R:W137	7.41	Yes	Yes	0	9	9
69	R:R:L103	R:R:N422	6.87	No	Yes	0	9	9
70	R:R:L103	R:R:Y426	7.03	No	Yes	0	9	9
71	R:R:I106	R:R:R110	5.01	No	No	4	9	9
72	R:R:I106	R:R:Y426	4.84	No	Yes	4	9	9
73	R:R:M188	R:R:S107	4.6	No	No	0	9	9
74	R:R:S107	R:R:V191	4.85	No	No	0	9	9
75	R:R:S107	R:R:Y192	13.99	No	Yes	0	9	9
76	R:R:L108	R:R:W112	10.25	No	Yes	0	7	7
77	R:R:D109	R:R:Y120	9.2	Yes	Yes	2	9	9
78	R:R:D109	R:R:R124	13.1	Yes	Yes	2	9	8
79	R:R:R110	R:R:Y192	4.12	No	Yes	0	9	9
80	R:R:R110	R:R:Y426	7.2	No	Yes	4	9	9
81	R:R:W112	R:R:Y111	5.79	Yes	Yes	0	7	9
82	R:R:S115	R:R:Y111	12.72	No	Yes	0	9	9
83	R:R:V191	R:R:Y111	5.05	No	Yes	0	9	9
84	R:R:R194	R:R:Y111	11.32	No	Yes	0	7	9
85	R:R:R116	R:R:W112	13.99	No	Yes	2	7	7
86	R:R:W112	R:R:Y120	9.65	Yes	Yes	2	7	9
87	R:R:R128	R:R:W112	5	No	Yes	2	8	7
88	R:R:A113	R:R:R124	5.53	No	Yes	0	9	8
89	R:R:I198	R:R:V114	4.61	No	No	0	8	9
90	R:R:E119	R:R:R116	9.3	No	No	0	6	7
91	R:R:R116	R:R:Y120	8.23	No	Yes	2	7	9
92	R:R:R124	R:R:Y120	14.4	Yes	Yes	2	8	9
93	R:R:R128	R:R:Y120	6.17	No	Yes	2	8	9
94	R:R:P146	R:R:P147	5.84	No	No	7	8	8
95	R:R:P146	R:R:Y172	6.95	No	Yes	7	8	8
96	R:R:P147	R:R:Y172	12.52	No	Yes	7	8	8
97	R:R:I173	R:R:N167	5.66	No	No	0	8	8
98	R:R:W171	R:R:Y172	5.79	No	Yes	0	5	8
99	R:R:S176	R:R:Y172	11.45	No	Yes	0	9	8
100	R:R:I173	R:R:Y391	15.71	No	Yes	0	8	8
101	R:R:S176	R:R:Y391	3.82	No	Yes	0	9	8
102	R:R:F182	R:R:S177	5.28	No	Yes	1	8	8
103	R:R:F388	R:R:S177	3.96	Yes	Yes	1	9	8
104	R:R:S177	R:R:Y391	3.82	Yes	Yes	1	8	8
105	R:R:S177	R:R:S392	4.89	Yes	No	1	8	8
106	L:L:?1	R:R:S180	6.13	Yes	No	0	0	9
107	R:R:F181	R:R:F182	6.43	Yes	No	1	9	8
108	R:R:C185	R:R:F181	11.17	No	Yes	1	8	9
109	R:R:F181	R:R:F380	7.5	Yes	Yes	1	9	9
110	R:R:F181	R:R:F385	7.5	Yes	Yes	0	9	8
111	R:R:F181	R:R:F388	17.15	Yes	Yes	1	9	9
112	R:R:F182	R:R:S392	3.96	No	No	1	8	8
113	R:R:C185	R:R:F380	5.59	No	Yes	1	8	9
114	R:R:F380	R:R:M188	4.98	Yes	No	0	9	9
115	R:R:I189	R:R:I377	5.89	No	No	0	6	8
116	R:R:I195	R:R:Y192	4.84	No	Yes	0	9	9
117	R:R:V376	R:R:Y192	5.05	No	Yes	0	9	9
118	R:R:K200	R:R:Y196	5.97	No	Yes	0	7	8
119	R:R:F369	R:R:Y196	5.16	Yes	Yes	0	9	8
120	R:R:I198	R:R:R201	6.26	No	No	0	8	6
121	R:R:A199	R:R:F369	8.32	No	Yes	0	9	9
122	R:R:N203	R:R:Q362	7.92	No	No	0	5	5
123	R:R:N203	R:R:R365	12.05	No	No	0	5	8
124	R:R:F369	R:R:N203	4.83	Yes	No	0	9	5
125	R:R:E366	R:R:F369	7	No	Yes	0	9	9
126	R:R:R368	R:R:V372	3.92	No	No	8	9	9
127	R:R:F429	R:R:R368	7.48	No	No	8	8	9
128	R:R:F371	R:R:V375	5.24	No	No	0	7	9
129	R:R:F429	R:R:V372	6.55	No	No	8	8	9
130	R:R:I425	R:R:V379	4.61	No	No	0	9	8
131	R:R:F380	R:R:W384	5.01	Yes	Yes	1	9	9
132	R:R:F380	R:R:N418	4.83	Yes	Yes	1	9	9
133	R:R:C383	R:R:N418	9.45	No	Yes	0	9	9
134	R:R:F388	R:R:W384	8.02	Yes	Yes	1	9	9
135	R:R:G415	R:R:W384	8.44	No	Yes	0	9	9
136	R:R:N418	R:R:W384	10.17	Yes	Yes	1	9	9
137	L:L:?1	R:R:W384	5.58	Yes	Yes	1	0	9
138	R:R:F385	R:R:P386	4.33	Yes	No	0	8	9
139	R:R:F411	R:R:P386	13	Yes	No	0	7	9
140	R:R:F387	R:R:F388	6.43	Yes	Yes	1	9	9
141	R:R:F387	R:R:Y391	8.25	Yes	Yes	1	9	8
142	R:R:F387	R:R:F408	6.43	Yes	No	0	9	7
143	L:L:?1	R:R:F387	17.89	Yes	Yes	1	0	9
144	L:L:?1	R:R:F388	5.96	Yes	Yes	1	0	9
145	R:R:F411	R:R:S390	3.96	Yes	No	0	7	8
146	L:L:?1	R:R:Y391	6.7	Yes	Yes	1	0	8
147	R:R:F410	R:R:F411	4.29	No	Yes	0	7	7
148	R:R:F410	R:R:I414	10.05	No	No	0	7	9
149	R:R:F412	R:R:Y416	9.28	No	Yes	1	8	8
150	L:L:?1	R:R:F412	17.89	Yes	No	1	0	8
151	R:R:W413	R:R:Y416	5.79	No	Yes	0	9	8
152	L:L:?1	R:R:Y416	8.61	Yes	Yes	1	0	8
153	R:R:N418	R:R:N422	10.9	Yes	Yes	0	9	9
154	R:R:I425	R:R:Y426	7.25	No	Yes	0	9	9
155	R:R:F433	R:R:T427	14.27	Yes	No	3	9	9
156	R:R:F437	R:R:T427	7.78	Yes	No	3	9	9
157	R:R:F429	R:R:I428	5.02	No	No	0	8	7
158	R:R:D432	R:R:N430	6.73	No	No	0	9	9
159	R:R:F433	R:R:N430	8.46	Yes	No	0	9	9
160	R:R:D432	R:R:Q431	5.22	No	No	0	9	4
161	R:R:Q431	R:R:R435	7.01	No	No	0	4	6
162	R:R:F433	R:R:F437	4.29	Yes	Yes	3	9	9
163	R:R:R435	R:R:R438	7.46	No	No	0	6	7
164	R:R:C104	R:R:P184	3.77	No	No	0	8	9
165	R:R:T370	R:R:Y196	3.75	No	Yes	0	9	8
166	R:R:H405	R:R:Q409	3.71	No	No	0	5	5
167	R:R:F411	R:R:L407	3.65	Yes	No	0	7	7
168	R:R:G179	R:R:I178	3.53	No	No	0	7	7
169	R:R:L51	R:R:Y426	3.52	No	Yes	0	8	9
170	R:R:L75	R:R:Y77	3.52	No	No	0	6	4
171	R:R:L166	R:R:Y391	3.52	No	Yes	0	7	8
172	R:R:L373	R:R:Y192	3.52	No	Yes	0	9	9
173	R:R:L373	R:R:Y196	3.52	No	Yes	0	9	8
174	R:R:P126	R:R:T125	3.5	No	No	0	7	9
175	R:R:A140	R:R:S98	3.42	No	No	0	9	9
176	R:R:I23	R:R:P67	3.39	No	No	0	8	9
177	R:R:A55	R:R:V33	3.39	No	No	0	9	9
178	R:R:N72	R:R:W78	3.39	No	Yes	0	7	9
179	R:R:A62	R:R:T26	3.36	No	No	0	9	9
180	R:R:C104	R:R:I187	3.27	No	No	0	8	8
181	R:R:C185	R:R:I189	3.27	No	No	0	8	6
182	R:R:A55	R:R:I34	3.25	No	No	0	9	8
183	R:R:F385	R:R:F389	3.22	Yes	No	0	8	8
184	R:R:T427	R:R:V33	3.17	No	No	0	9	9
185	R:R:I27	R:R:T63	3.04	No	No	0	7	6
186	R:R:I59	R:R:T63	3.04	No	No	0	8	6
187	R:R:L22	R:R:S420	3	No	No	0	8	8
188	R:R:L421	R:R:V379	2.98	No	No	0	7	8
189	R:R:N48	R:R:V37	2.96	No	No	0	9	9
190	R:R:N30	R:R:T26	2.92	Yes	No	0	9	9
191	R:R:W78	R:R:Y88	2.89	Yes	Yes	0	9	8
192	R:R:I34	R:R:L38	2.85	No	No	0	8	6
193	R:R:I129	R:R:L49	2.85	No	No	0	9	8
194	R:R:K130	R:R:L49	2.82	No	No	0	6	8
195	R:R:A36	R:R:F437	2.77	No	Yes	0	9	9
196	R:R:E119	R:R:K123	2.7	No	No	0	6	6
197	R:R:E86	R:R:L148	2.65	No	No	0	8	9
198	R:R:F385	R:R:V381	2.62	Yes	No	0	8	8
199	R:R:A57	R:R:W137	2.59	No	Yes	0	9	9
200	R:R:F28	R:R:L32	2.44	No	Yes	0	6	9
201	R:R:F389	R:R:L393	2.44	No	No	0	8	7
202	R:R:L89	R:R:Y88	2.34	No	Yes	0	8	8
203	R:R:A183	R:R:P184	1.87	No	No	0	7	9
204	R:R:A36	R:R:A436	1.79	No	No	0	9	9
205	R:R:P184	R:R:V101	1.77	No	No	0	9	8
206	R:R:G378	R:R:I377	1.76	No	No	0	8	8
207	R:R:A141	R:R:S144	1.71	No	No	0	7	9
208	R:R:G76	R:R:N72	1.7	No	No	0	8	7
209	R:R:L145	R:R:P146	1.64	No	No	0	7	8
210	R:R:L407	R:R:P404	1.64	No	No	0	7	8
211	R:R:C417	R:R:I414	1.64	No	No	0	7	9
212	R:R:V372	R:R:V376	1.6	No	No	0	9	9
213	R:R:V375	R:R:V379	1.6	No	No	0	9	8
214	R:R:A16	R:R:L74	1.58	No	No	0	7	8
215	R:R:A90	R:R:L148	1.58	No	No	0	9	9
216	R:R:A140	R:R:L94	1.58	No	No	0	9	8
217	R:R:I198	R:R:S115	1.55	No	No	0	8	9
218	R:R:I428	R:R:V424	1.54	No	No	0	7	7
219	R:R:I139	R:R:T135	1.52	No	No	0	7	5
220	R:R:L91	R:R:V87	1.49	No	No	0	7	7
221	R:R:I15	R:R:I19	1.47	No	No	0	8	7
222	R:R:L24	R:R:T20	1.47	No	No	0	5	6
223	R:R:L64	R:R:T63	1.47	No	No	0	6	6
224	R:R:I149	R:R:L145	1.43	No	No	0	6	7
225	R:R:I178	R:R:L174	1.43	No	No	0	7	7
226	R:R:I189	R:R:L193	1.43	No	No	0	6	4
227	R:R:R127	R:R:T125	1.29	No	No	0	6	9
228	R:R:L197	R:R:Y196	1.17	No	Yes	0	5	8
229	R:R:R438	R:R:R439	1.07	No	No	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N30	6.426	5	0	9
2	R:R:L32	5.4575	4	0	9
3	R:R:Q47	7.975	4	2	9
4	R:R:F50	6.058	5	0	9
5	R:R:D58	8.395	4	0	9
6	R:R:W78	6.4675	4	6	9
7	R:R:Y88	5.66	5	0	8
8	R:R:H102	5.55	5	5	9
9	R:R:D109	7.75	4	2	9
10	R:R:Y111	8.72	4	0	9
11	R:R:W112	8.936	5	2	7
12	R:R:Y120	9.53	5	2	9
13	R:R:R124	12.93	4	2	8
14	R:R:W137	7.21	4	0	9
15	R:R:Y172	9.1775	4	7	8
16	R:R:S177	4.4875	4	1	8
17	R:R:F181	9.95	5	1	9
18	R:R:Y192	6.304	5	0	9
19	R:R:Y196	3.914	5	0	8
20	R:R:F369	6.3275	4	0	9
21	R:R:F380	5.48833	6	1	9
22	R:R:W384	7.90857	7	1	9
23	R:R:F385	4.4175	4	0	8
24	R:R:F387	9.75	4	1	9
25	R:R:F388	8.304	5	1	9
26	R:R:Y391	6.97	6	1	8
27	R:R:F411	6.225	4	0	7
28	R:R:Y416	7.15333	6	1	8
29	R:R:N418	8.8375	4	1	9
30	R:R:N422	7.155	4	0	9
31	R:R:Y426	5.968	5	4	9
32	R:R:F433	8.806	5	3	9
33	R:R:F437	6.45	4	3	9
34	L:L:?1	9.494	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I19	R:R:W413	11.9006	5.87	No	No	0	7	9
2	R:R:W413	R:R:Y416	20.9441	5.79	No	Yes	0	9	8
3	R:R:N30	R:R:T26	12.7826	2.92	Yes	No	0	9	9
4	R:R:D58	R:R:N30	82.323	12.12	Yes	Yes	0	9	9
5	R:R:D58	R:R:N422	88.7329	6.73	Yes	Yes	0	9	9
6	R:R:N418	R:R:N422	100	10.9	Yes	Yes	0	9	9
7	R:R:N418	R:R:W384	66.7453	10.17	Yes	Yes	1	9	9
8	L:L:?1	R:R:W384	84.3354	5.58	Yes	Yes	1	0	9
9	L:L:?1	R:R:Y416	48.1118	8.61	Yes	Yes	1	0	8
10	R:R:A55	R:R:N30	60.7081	4.69	No	Yes	0	9	9
11	R:R:I59	R:R:N30	10.2733	4.25	No	Yes	0	8	9
12	R:R:A55	R:R:V33	54.7453	3.39	No	No	0	9	9
13	R:R:T427	R:R:V33	52.6584	3.17	No	No	0	9	9
14	R:R:F437	R:R:T427	20.646	7.78	Yes	No	3	9	9
15	R:R:F437	R:R:L32	15.1925	10.96	Yes	Yes	0	9	9
16	R:R:F433	R:R:T427	30.1615	14.27	Yes	No	3	9	9
17	R:R:D432	R:R:N430	15.2671	6.73	No	No	0	9	9
18	R:R:F433	R:R:N430	17.7267	8.46	Yes	No	0	9	9
19	R:R:D109	R:R:Q47	18.3106	3.92	Yes	Yes	2	9	9
20	R:R:D109	R:R:F50	28.8944	4.78	Yes	Yes	0	9	9
21	R:R:F50	R:R:I106	41.8261	5.02	Yes	No	0	9	9
22	R:R:I106	R:R:Y426	35.8137	4.84	No	Yes	4	9	9
23	R:R:L103	R:R:Y426	63.7019	7.03	No	Yes	0	9	9
24	R:R:L103	R:R:N422	64.9565	6.87	No	Yes	0	9	9
25	R:R:P46	R:R:Q47	14.3478	4.74	No	Yes	0	8	9
26	R:R:P126	R:R:P46	10.795	7.79	No	No	0	7	8
27	R:R:H102	R:R:L54	47.0559	3.86	Yes	No	0	9	9
28	R:R:L54	R:R:N422	49.1677	4.12	No	Yes	0	9	9
29	R:R:H102	R:R:W137	26.9317	7.41	Yes	Yes	0	9	9
30	R:R:S69	R:R:Y88	19.3789	6.36	No	Yes	0	8	8
31	R:R:S69	R:R:Y416	21.4037	5.09	No	Yes	0	8	8
32	R:R:W78	R:R:Y88	23.7516	2.89	Yes	Yes	0	9	8
33	R:R:S98	R:R:W137	12.7826	14.83	No	Yes	0	9	9
34	R:R:A140	R:R:S98	10.2733	3.42	No	No	0	9	9
35	R:R:F380	R:R:W384	29.8509	5.01	Yes	Yes	1	9	9
36	R:R:H102	R:R:V136	15.2671	6.92	Yes	No	0	9	9
37	R:R:V101	R:R:V136	12.7826	6.41	No	No	0	8	9
38	R:R:F380	R:R:M188	54.8696	4.98	Yes	No	0	9	9
39	R:R:M188	R:R:S107	53.8509	4.6	No	No	0	9	9
40	R:R:S107	R:R:V191	31.7888	4.85	No	No	0	9	9
41	R:R:S107	R:R:Y192	29.1056	13.99	No	Yes	0	9	9
42	R:R:V191	R:R:Y111	29.7516	5.05	No	Yes	0	9	9
43	R:R:W112	R:R:Y111	18.7578	5.79	Yes	Yes	0	7	9
44	R:R:W112	R:R:Y120	11.2671	9.65	Yes	Yes	2	7	9
45	R:R:S115	R:R:Y111	10.2112	12.72	No	Yes	0	9	9
46	L:L:?1	R:R:Y391	27.9255	6.7	Yes	Yes	1	0	8
47	R:R:S176	R:R:Y391	22.7702	3.82	No	Yes	0	9	8
48	R:R:S176	R:R:Y172	19.5901	11.45	No	Yes	0	9	8
49	L:L:?1	R:R:F388	13.6646	5.96	Yes	Yes	1	0	9
50	R:R:F181	R:R:F388	19.7764	17.15	Yes	Yes	1	9	9
51	R:R:C185	R:R:F380	12.9068	5.59	No	Yes	1	8	9
52	R:R:F181	R:R:F385	38.4472	7.5	Yes	Yes	0	9	8
53	R:R:C185	R:R:I189	15.441	3.27	No	No	0	8	6
54	R:R:V376	R:R:Y192	14.4348	5.05	No	Yes	0	9	9
55	R:R:L373	R:R:Y192	26.3478	3.52	No	Yes	0	9	9
56	R:R:L373	R:R:Y196	24.3602	3.52	No	Yes	0	9	8
57	R:R:F369	R:R:Y196	14.9689	5.16	Yes	Yes	0	9	8
58	R:R:V372	R:R:V376	12.1118	1.6	No	No	0	9	9
59	R:R:I425	R:R:Y426	12.472	7.25	No	Yes	0	9	9
60	R:R:F385	R:R:P386	26.0248	4.33	Yes	No	0	8	9
61	R:R:F411	R:R:P386	22.8571	13	Yes	No	0	7	9
62	R:R:D432	R:R:Q431	10.2733	5.22	No	No	0	9	4
63	R:R:P184	R:R:V101	10.2733	1.77	No	No	0	9	8
64	R:R:D92	R:R:I65	20.1491	12.59	No	No	0	9	9
65	R:R:R110	R:R:Y192	26.6335	4.12	No	Yes	0	9	9
66	R:R:R110	R:R:Y426	19.0186	7.2	No	Yes	4	9	9
67	L:L:?1	R:R:D92	21.9503	9.97	Yes	No	1	0	9
68	R:R:I65	R:R:Y88	18.1366	8.46	No	Yes	0	9	8
69	R:R:F380	R:R:N418	33.8882	4.83	Yes	Yes	1	9	9
70	R:R:D109	R:R:Y120	10.7329	9.2	Yes	Yes	2	9	9
71	R:R:F181	R:R:F380	31.6149	7.5	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D92	R:R:I65	12.59	1	No	No	9	9	1	2
R:R:I66	R:R:Y416	7.25	0	No	Yes	8	8	2	1
R:R:S69	R:R:Y416	5.09	0	No	Yes	8	8	2	1
R:R:D92	R:R:Y416	6.9	1	No	Yes	9	8	1	1
L:L:?1	R:R:D92	9.97	1	Yes	No	0	9	0	1
L:L:?1	R:R:V93	9.73	1	Yes	No	0	9	0	1
R:R:C96	R:R:W384	5.22	1	No	Yes	9	9	1	1
L:L:?1	R:R:C96	6.48	1	Yes	No	0	9	0	1
R:R:S180	R:R:T97	7.99	0	No	No	9	9	1	2
R:R:F380	R:R:I100	5.02	1	Yes	No	9	9	2	2
R:R:I100	R:R:W384	12.92	1	No	Yes	9	9	2	1
R:R:I173	R:R:Y391	15.71	0	No	Yes	8	8	2	1
R:R:S176	R:R:Y391	3.82	0	No	Yes	9	8	2	1
R:R:F388	R:R:S177	3.96	1	Yes	Yes	9	8	1	2
R:R:S177	R:R:Y391	3.82	1	Yes	Yes	8	8	2	1
L:L:?1	R:R:S180	6.13	1	Yes	No	0	9	0	1
R:R:F181	R:R:F380	7.5	1	Yes	Yes	9	9	2	2
R:R:F181	R:R:F388	17.15	1	Yes	Yes	9	9	2	1
R:R:F380	R:R:W384	5.01	1	Yes	Yes	9	9	2	1
R:R:F380	R:R:N418	4.83	1	Yes	Yes	9	9	2	2
R:R:F388	R:R:W384	8.02	1	Yes	Yes	9	9	1	1
R:R:G415	R:R:W384	8.44	0	No	Yes	9	9	2	1
R:R:N418	R:R:W384	10.17	1	Yes	Yes	9	9	2	1
L:L:?1	R:R:W384	5.58	1	Yes	Yes	0	9	0	1
R:R:F387	R:R:F388	6.43	1	Yes	Yes	9	9	1	1
R:R:F387	R:R:Y391	8.25	1	Yes	Yes	9	8	1	1
R:R:F387	R:R:F408	6.43	1	Yes	No	9	7	1	2
L:L:?1	R:R:F387	17.89	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F388	5.96	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y391	6.7	1	Yes	Yes	0	8	0	1
R:R:F412	R:R:Y416	9.28	1	No	Yes	8	8	1	1
L:L:?1	R:R:F412	17.89	1	Yes	No	0	8	0	1
R:R:W413	R:R:Y416	5.79	0	No	Yes	9	8	2	1
L:L:?1	R:R:Y416	8.61	1	Yes	Yes	0	8	0	1
R:R:L166	R:R:Y391	3.52	0	No	Yes	7	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6K41_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.82
Number of Linked Nodes	209
Number of Links	229
Number of Hubs	34
Number of Links mediated by Hubs	131
Number of Communities	8
Number of Nodes involved in Communities	42
Number of Links involved in Communities	57

Path Summary
Number Of Nodes in MetaPath	72
Number Of Links MetaPath	71
Number of Shortest Paths	22577
Length Of Smallest Path	3
Average Path Length	10.7303
Length of Longest Path	23
Minimum Path Strength	1.535
Average Path Strength	6.64708
Maximum Path Strength	17.89
Minimum Path Correlation	0.7
Average Path Correlation	0.899589
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	45.9895
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.52
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • WD40 repeat-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • WD40 repeat-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CZX
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	CZX
Name	Dexmedetomidine
Synonyms	dexemedetomidine
Identifier
Formula	C13 H16 N2
Molecular Weight	200.28
SMILES
PubChem	5311068
Formal Charge	0
Total Atoms	31
Total Chiral Atoms	1
Total Bonds	32
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P18089
Sequence	>6K41_nogp_Chain_R A T A A I A A A I T F L I L F T I F G N A L V I L A V L T S R S L R A P Q N L F L V S L A A A D I L V A T L I I P F S L A N E L L G Y W C E V Y L A L D V L F C T S S I V H L C A I S L D R Y W A V S R A L E Y N S K R T P R R I K C I I L T V W L I A A V I S L P P L I C K L N A W Y I L A S S I G S F F A P C L I M I L V Y L R I Y L I A K R S N A Q L T R E K R F T F V L A V V I G V F V L C W F P F F F S Y S L P H G L F Q F F F W I G Y C N S S L N P V I Y T I F N Q D F R R A F R R I L C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6K41	A	Amine	Adrenergic	α_2b	Homo sapiens	Dexmedetomidine	-	Go/β1/γ2	2.9	2020-04-15	doi.org/10.1038/s41589-020-0492-2
	6K41 (No Gprot)	A	Amine	Adrenergic	α_2b	Homo sapiens	Dexmedetomidine	-		2.9	2020-04-15	doi.org/10.1038/s41589-020-0492-2
	6K42	A	Amine	Adrenergic	α_2b	Homo sapiens	Dexmedetomidine	-	Gi1/β1/γ2	4.1	2020-04-15	doi.org/10.1038/s41589-020-0492-2
	6K42 (No Gprot)	A	Amine	Adrenergic	α_2b	Homo sapiens	Dexmedetomidine	-		4.1	2020-04-15	doi.org/10.1038/s41589-020-0492-2

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6K41_nogp.zip

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