psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A16	R:R:L70	4.73	No	No	0	7	8
2	R:R:A16	R:R:L74	3.15	No	No	0	7	8
3	R:R:I19	R:R:L70	2.85	No	No	0	7	8
4	R:R:I19	R:R:W413	7.05	No	No	0	7	9
5	R:R:L22	R:R:S420	4.5	No	No	0	8	8
6	R:R:I23	R:R:I27	2.94	No	No	0	8	7
7	R:R:I23	R:R:I66	5.89	No	No	0	8	8
8	R:R:F25	R:R:S420	6.61	No	No	0	5	8
9	R:R:N30	R:R:T26	4.39	Yes	No	0	9	9
10	R:R:A62	R:R:T26	3.36	No	No	0	9	9
11	R:R:S420	R:R:T26	3.2	No	No	0	8	9
12	R:R:G29	R:R:P423	4.06	No	No	0	9	9
13	R:R:A55	R:R:N30	4.69	No	Yes	0	9	9
14	R:R:D58	R:R:N30	12.12	Yes	Yes	0	9	9
15	R:R:N30	R:R:P423	11.4	Yes	No	0	9	9
16	R:R:F437	R:R:L32	3.65	No	No	0	9	9
17	R:R:I440	R:R:L32	2.85	No	No	0	8	9
18	R:R:T427	R:R:V33	3.17	No	No	0	9	9
19	R:R:I34	R:R:L38	2.85	No	No	0	8	6
20	R:R:A55	R:R:I34	3.25	No	No	0	9	8
21	R:R:L35	R:R:T39	2.95	No	No	0	6	8
22	R:R:I440	R:R:L35	2.85	No	No	0	8	6
23	R:R:N48	R:R:V37	2.96	No	No	0	9	9
24	R:R:V37	R:R:V52	4.81	No	No	0	9	8
25	R:R:L43	R:R:S40	7.51	No	No	0	9	8
26	R:R:R41	R:R:R44	7.46	No	No	0	8	8
27	R:R:D432	R:R:S42	10.31	No	No	0	9	7
28	R:R:L43	R:R:N48	5.49	No	No	4	9	9
29	R:R:F433	R:R:L43	12.18	Yes	No	4	9	9
30	R:R:A45	R:R:Q47	4.55	No	No	0	8	9
31	R:R:P46	R:R:Q47	3.16	No	No	0	8	9
32	R:R:P126	R:R:P46	7.79	No	No	0	7	8
33	R:R:Q47	R:R:R124	11.68	No	Yes	0	9	8
34	R:R:F433	R:R:N48	6.04	Yes	No	4	9	9
35	R:R:I129	R:R:L49	5.71	No	No	0	9	8
36	R:R:F50	R:R:I106	3.77	Yes	No	0	9	9
37	R:R:D109	R:R:F50	4.78	No	Yes	0	9	9
38	R:R:F50	R:R:I129	6.28	Yes	No	0	9	9
39	R:R:F50	R:R:I132	6.28	Yes	No	0	9	7
40	R:R:F433	R:R:L51	3.65	Yes	No	0	9	8
41	R:R:H102	R:R:S53	6.97	Yes	No	6	9	9
42	R:R:I133	R:R:S53	7.74	No	No	6	9	9
43	R:R:D58	R:R:L54	4.07	Yes	No	2	9	9
44	R:R:L54	R:R:S99	3	No	No	2	9	9
45	R:R:L54	R:R:N422	6.87	No	No	2	9	9
46	R:R:D58	R:R:S99	2.94	Yes	No	2	9	9
47	R:R:D58	R:R:S419	8.83	Yes	No	0	9	9
48	R:R:D58	R:R:N422	10.77	Yes	No	2	9	9
49	R:R:I59	R:R:T63	3.04	No	No	0	8	6
50	R:R:F95	R:R:L60	10.96	Yes	No	0	8	8
51	R:R:S419	R:R:V61	6.46	No	No	0	9	9
52	R:R:L64	R:R:T63	2.95	No	No	0	6	6
53	R:R:I65	R:R:L64	2.85	Yes	No	0	9	6
54	R:R:F95	R:R:L64	4.87	Yes	No	0	8	6
55	R:R:I65	R:R:Y88	8.46	Yes	Yes	0	9	8
56	R:R:D92	R:R:I65	7	No	Yes	1	9	9
57	R:R:I65	R:R:Y416	3.63	Yes	Yes	1	9	8
58	R:R:I66	R:R:P67	3.39	No	No	0	8	9
59	R:R:F68	R:R:F80	3.22	No	No	0	7	8
60	R:R:F68	R:R:Y88	5.16	No	Yes	0	7	8
61	R:R:S69	R:R:Y88	5.09	No	Yes	0	8	8
62	R:R:S69	R:R:Y416	7.63	No	Yes	0	8	8
63	R:R:N72	R:R:W78	3.39	No	Yes	0	7	9
64	R:R:E73	R:R:Q409	6.37	No	No	0	8	5
65	R:R:E73	R:R:W413	4.36	No	No	0	8	9
66	R:R:L75	R:R:Y77	4.69	No	No	0	6	4
67	R:R:Y77	R:R:Y79	9.93	No	No	0	4	5
68	R:R:C85	R:R:W78	3.92	No	Yes	3	9	9
69	R:R:W78	R:R:Y88	5.79	Yes	Yes	0	9	8
70	R:R:C164	R:R:W78	13.06	No	Yes	3	9	9
71	R:R:F80	R:R:Y79	14.44	No	No	0	8	5
72	R:R:R81	R:R:W84	23.99	No	No	0	8	5
73	R:R:C85	R:R:L89	3.17	No	No	3	9	8
74	R:R:C164	R:R:C85	7.28	No	No	3	9	9
75	R:R:C164	R:R:L89	3.17	No	No	3	9	8
76	R:R:L166	R:R:L89	4.15	No	No	0	7	8
77	R:R:F95	R:R:L91	6.09	Yes	No	0	8	7
78	R:R:D92	R:R:Y416	8.05	No	Yes	1	9	8
79	L:L:?1	R:R:D92	9.97	Yes	No	1	0	9
80	L:L:?1	R:R:V93	3.65	Yes	No	0	0	9
81	R:R:F95	R:R:L94	6.09	Yes	No	0	8	8
82	R:R:L94	R:R:S144	10.51	No	No	0	8	9
83	L:L:?1	R:R:C96	9.07	Yes	No	0	0	9
84	R:R:I143	R:R:T97	6.08	No	No	0	8	9
85	R:R:S180	R:R:T97	7.99	No	No	1	9	9
86	L:L:?1	R:R:T97	3.61	Yes	No	1	0	9
87	R:R:S98	R:R:W137	12.36	No	No	0	9	9
88	R:R:I100	R:R:P184	3.39	No	No	0	9	9
89	R:R:F380	R:R:I100	3.77	Yes	No	1	9	9
90	R:R:I100	R:R:W384	8.22	No	Yes	1	9	9
91	R:R:V101	R:R:V136	4.81	No	No	0	8	9
92	R:R:H102	R:R:I133	3.98	Yes	No	6	9	9
93	R:R:H102	R:R:V136	6.92	Yes	No	0	9	9
94	R:R:H102	R:R:W137	10.58	Yes	No	0	9	9
95	R:R:L103	R:R:Y426	3.52	No	Yes	0	9	9
96	R:R:C104	R:R:P184	3.77	No	No	0	8	9
97	R:R:C104	R:R:M188	3.24	No	Yes	0	8	9
98	R:R:I106	R:R:R110	5.01	No	No	0	9	9
99	R:R:M188	R:R:S107	4.6	Yes	No	1	9	9
100	R:R:S107	R:R:V191	4.85	No	No	0	9	9
101	R:R:S107	R:R:Y192	11.45	No	Yes	1	9	9
102	R:R:L108	R:R:W112	15.94	No	No	0	7	7
103	R:R:D109	R:R:Y120	4.6	No	Yes	5	9	9
104	R:R:D109	R:R:R124	13.1	No	Yes	5	9	8
105	R:R:R110	R:R:Y426	8.23	No	Yes	0	9	9
106	R:R:W112	R:R:Y111	4.82	No	Yes	0	7	9
107	R:R:S115	R:R:Y111	10.17	No	Yes	0	9	9
108	R:R:V191	R:R:Y111	6.31	No	Yes	0	9	9
109	R:R:R194	R:R:Y111	8.23	No	Yes	0	7	9
110	R:R:W112	R:R:Y120	15.43	No	Yes	0	7	9
111	R:R:A113	R:R:R124	4.15	No	Yes	0	9	8
112	R:R:I198	R:R:V114	4.61	No	No	0	8	9
113	R:R:E119	R:R:R116	8.14	No	No	0	6	7
114	R:R:R116	R:R:Y120	13.38	No	Yes	0	7	9
115	R:R:R124	R:R:Y120	13.38	Yes	Yes	5	8	9
116	R:R:L145	R:R:P146	3.28	No	No	0	7	8
117	R:R:I149	R:R:L145	8.56	No	No	0	6	7
118	R:R:P146	R:R:P147	5.84	No	No	7	8	8
119	R:R:P146	R:R:Y172	9.74	No	Yes	7	8	8
120	R:R:P147	R:R:Y172	6.95	No	Yes	7	8	8
121	R:R:W171	R:R:Y150	6.75	No	No	0	5	6
122	R:R:K165	R:R:Q163	5.42	No	No	0	4	4
123	R:R:Q168	R:R:Y172	5.64	No	Yes	0	6	8
124	R:R:E169	R:R:W171	4.36	No	No	0	7	5
125	R:R:W171	R:R:Y172	6.75	No	Yes	0	5	8
126	R:R:S176	R:R:Y172	13.99	No	Yes	0	9	8
127	R:R:I173	R:R:Y391	13.3	No	No	0	8	8
128	R:R:A395	R:R:L174	3.15	No	No	0	8	7
129	R:R:F182	R:R:S177	5.28	Yes	No	1	8	8
130	R:R:S177	R:R:Y391	5.09	No	No	0	8	8
131	R:R:S177	R:R:S392	4.89	No	No	1	8	8
132	R:R:G179	R:R:I178	3.53	No	No	0	7	7
133	R:R:F182	R:R:I178	3.77	Yes	No	0	8	7
134	L:L:?1	R:R:S180	6.13	Yes	No	1	0	9
135	R:R:F181	R:R:F182	6.43	Yes	Yes	1	9	8
136	R:R:C185	R:R:F181	11.17	No	Yes	0	8	9
137	R:R:F181	R:R:F380	5.36	Yes	Yes	1	9	9
138	R:R:F181	R:R:W384	4.01	Yes	Yes	1	9	9
139	R:R:F181	R:R:F385	6.43	Yes	Yes	0	9	8
140	R:R:F181	R:R:F388	24.65	Yes	No	1	9	9
141	R:R:F182	R:R:S392	6.61	Yes	No	1	8	8
142	R:R:C185	R:R:I189	3.27	No	No	0	8	6
143	R:R:M188	R:R:Y192	3.59	Yes	Yes	1	9	9
144	R:R:F380	R:R:M188	6.22	Yes	Yes	1	9	9
145	R:R:I189	R:R:I377	2.94	No	No	0	6	8
146	R:R:V376	R:R:Y192	5.05	No	Yes	0	9	9
147	R:R:I377	R:R:Y192	3.63	No	Yes	0	8	9
148	R:R:I195	R:R:L373	2.85	No	No	0	9	9
149	R:R:K200	R:R:Y196	8.36	No	Yes	0	7	8
150	R:R:F369	R:R:Y196	4.13	No	Yes	0	9	8
151	R:R:T370	R:R:Y196	7.49	No	Yes	0	9	8
152	R:R:L373	R:R:Y196	3.52	No	Yes	0	9	8
153	R:R:A199	R:R:F369	5.55	No	No	0	9	9
154	R:R:N203	R:R:Q362	13.2	No	No	0	5	5
155	R:R:E366	R:R:F369	3.5	No	No	0	9	9
156	R:R:F371	R:R:V375	7.87	No	No	0	7	9
157	R:R:F429	R:R:V372	11.8	No	No	0	8	9
158	R:R:V376	R:R:Y426	3.79	No	Yes	0	9	9
159	R:R:I425	R:R:V379	3.07	No	No	0	9	8
160	R:R:F380	R:R:W384	7.02	Yes	Yes	1	9	9
161	R:R:C383	R:R:N418	3.15	No	No	0	9	9
162	R:R:F388	R:R:W384	7.02	No	Yes	1	9	9
163	R:R:G415	R:R:W384	4.22	No	Yes	0	9	9
164	R:R:N418	R:R:W384	9.04	No	Yes	0	9	9
165	L:L:?1	R:R:W384	4.65	Yes	Yes	1	0	9
166	R:R:F385	R:R:P386	4.33	Yes	No	0	8	9
167	R:R:F411	R:R:P386	10.11	Yes	No	0	7	9
168	R:R:F387	R:R:F408	7.5	Yes	No	0	9	7
169	R:R:F387	R:R:F411	3.22	Yes	Yes	0	9	7
170	R:R:F387	R:R:F412	8.57	Yes	No	1	9	8
171	L:L:?1	R:R:F387	11.93	Yes	Yes	1	0	9
172	L:L:?1	R:R:F388	3.98	Yes	No	1	0	9
173	R:R:F389	R:R:L393	3.65	No	No	0	8	7
174	R:R:F411	R:R:S390	3.96	Yes	No	0	7	8
175	L:L:?1	R:R:Y391	10.52	Yes	No	0	0	8
176	R:R:F411	R:R:L407	3.65	Yes	No	0	7	7
177	R:R:F408	R:R:Q409	4.68	No	No	0	7	5
178	R:R:F410	R:R:I414	6.28	No	No	0	7	9
179	R:R:F412	R:R:Y416	14.44	No	Yes	1	8	8
180	L:L:?1	R:R:F412	14.91	Yes	No	1	0	8
181	R:R:W413	R:R:Y416	7.72	No	Yes	0	9	8
182	L:L:?1	R:R:Y416	5.74	Yes	Yes	1	0	8
183	R:R:N418	R:R:N422	13.62	No	No	0	9	9
184	R:R:I425	R:R:Y426	4.84	No	Yes	0	9	9
185	R:R:F433	R:R:T427	3.89	Yes	No	0	9	9
186	R:R:F437	R:R:T427	6.49	No	No	0	9	9
187	R:R:F429	R:R:I428	3.77	No	No	0	8	7
188	R:R:D432	R:R:N430	8.08	No	No	0	9	9
189	R:R:F433	R:R:N430	7.25	Yes	No	0	9	9
190	R:R:A436	R:R:R439	4.15	No	No	0	9	7
191	R:R:I440	R:R:L441	2.85	No	No	0	8	9
192	R:R:K130	R:R:L49	2.82	No	No	0	6	8
193	R:R:W78	R:R:W84	2.81	Yes	No	0	9	5
194	R:R:C131	R:R:R127	2.79	No	No	0	4	6
195	R:R:A105	R:R:F50	2.77	No	Yes	0	8	9
196	R:R:A71	R:R:Y79	2.67	No	No	0	7	5
197	R:R:R439	R:R:S40	2.64	No	No	0	7	8
198	R:R:F25	R:R:V424	2.62	No	No	0	5	7
199	R:R:F385	R:R:V381	2.62	Yes	No	0	8	8
200	R:R:A57	R:R:W137	2.59	No	No	0	9	9
201	R:R:F50	R:R:I133	2.51	Yes	No	0	9	9
202	R:R:I132	R:R:R128	2.51	No	No	0	7	8
203	R:R:I195	R:R:Y111	2.42	No	Yes	0	9	9
204	R:R:N203	R:R:R365	2.41	No	No	0	5	8
205	R:R:Q431	R:R:R434	2.34	No	No	0	4	9
206	R:R:F410	R:R:F411	2.14	No	Yes	0	7	7
207	R:R:C397	R:R:P398	1.88	No	No	0	8	4
208	R:R:A90	R:R:P147	1.87	No	No	0	9	8
209	R:R:A183	R:R:P184	1.87	No	No	0	7	9
210	R:R:C383	R:R:C417	1.82	No	No	0	9	7
211	R:R:C397	R:R:C401	1.82	No	No	0	8	5
212	R:R:A36	R:R:A436	1.79	No	No	0	9	9
213	R:R:P423	R:R:V33	1.77	No	No	0	9	9
214	R:R:P404	R:R:V403	1.77	No	No	0	8	6
215	R:R:G378	R:R:I377	1.76	No	No	0	8	8
216	R:R:P126	R:R:T125	1.75	No	No	0	7	9
217	R:R:A140	R:R:S98	1.71	No	No	0	9	9
218	R:R:A141	R:R:S144	1.71	No	No	0	7	9
219	R:R:A113	R:R:V114	1.7	No	No	0	9	9
220	R:R:A11	R:R:T12	1.68	No	No	0	6	6
221	R:R:C397	R:R:I396	1.64	No	No	0	8	7
222	R:R:S176	R:R:S180	1.63	No	No	0	9	9
223	R:R:A62	R:R:I66	1.62	No	No	0	9	8
224	R:R:A395	R:R:I173	1.62	No	No	0	8	8
225	R:R:V372	R:R:V376	1.6	No	No	0	9	9
226	R:R:V375	R:R:V379	1.6	No	No	0	9	8
227	R:R:C383	R:R:L421	1.59	No	No	0	9	7
228	R:R:A13	R:R:L74	1.58	No	No	0	7	8
229	R:R:A90	R:R:L148	1.58	No	No	0	9	9
230	R:R:I187	R:R:V191	1.54	No	No	0	8	9
231	R:R:I139	R:R:T135	1.52	No	No	0	7	5
232	R:R:F28	R:R:G29	1.51	No	No	0	6	9
233	R:R:L91	R:R:V87	1.49	No	No	0	7	7
234	R:R:L70	R:R:T20	1.47	No	No	0	8	6
235	R:R:P444	R:R:R443	1.44	No	No	0	5	6
236	R:R:I27	R:R:L24	1.43	No	No	0	7	5
237	R:R:I189	R:R:L193	1.43	No	No	0	6	4
238	R:R:P162	R:R:Y77	1.39	No	No	0	3	4
239	R:R:C442	R:R:R443	1.39	No	No	0	5	6
240	R:R:L186	R:R:L190	1.38	No	No	0	5	5
241	R:R:E119	R:R:K123	1.35	No	No	0	6	6
242	R:R:P444	R:R:W445	1.35	No	No	0	5	4
243	R:R:E366	R:R:L363	1.33	No	No	0	9	5
244	R:R:N430	R:R:Q431	1.32	No	No	0	9	4
245	R:R:E366	R:R:N203	1.31	No	No	0	9	5
246	R:R:R127	R:R:T125	1.29	No	No	0	6	9
247	R:R:I198	R:R:R201	1.25	No	No	0	8	6
248	R:R:H405	R:R:Q409	1.24	No	No	0	5	5
249	R:R:F21	R:R:L24	1.22	No	No	0	5	5
250	R:R:L197	R:R:Y196	1.17	No	Yes	0	5	8
251	R:R:Q362	R:R:R204	1.17	No	No	0	5	7
252	R:R:R358	R:R:R359	1.07	No	No	0	6	5
253	R:R:F385	R:R:F389	1.07	Yes	No	0	8	8
254	R:R:R82	R:R:W78	1	No	Yes	0	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N30	8.15	4	0	9
2	R:R:F50	4.39833	6	0	9
3	R:R:D58	7.746	5	2	9
4	R:R:I65	5.485	4	1	9
5	R:R:W78	4.995	6	3	9
6	R:R:Y88	6.125	4	0	8
7	R:R:F95	7.0025	4	0	8
8	R:R:H102	7.1125	4	6	9
9	R:R:Y111	6.39	5	0	9
10	R:R:Y120	11.6975	4	5	9
11	R:R:R124	10.5775	4	5	8
12	R:R:Y172	8.614	5	7	8
13	R:R:F181	9.675	6	1	9
14	R:R:F182	5.5225	4	1	8
15	R:R:M188	4.4125	4	1	9
16	R:R:Y192	5.93	4	1	9
17	R:R:Y196	4.934	5	0	8
18	R:R:F380	5.5925	4	1	9
19	R:R:W384	6.31143	7	1	9
20	R:R:F385	3.6125	4	0	8
21	R:R:F387	7.805	4	1	9
22	R:R:F411	4.616	5	0	7
23	R:R:Y416	7.86833	6	1	8
24	R:R:Y426	5.095	4	0	9
25	R:R:F433	6.602	5	4	9
26	L:L:?1	7.65091	11	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:W413	R:R:Y416	11.8593	7.72	No	Yes	0	9	8
2	L:L:?1	R:R:Y416	64.6231	5.74	Yes	Yes	1	0	8
3	L:L:?1	R:R:W384	100	4.65	Yes	Yes	1	0	9
4	R:R:N418	R:R:W384	66.3583	9.04	No	Yes	0	9	9
5	R:R:N418	R:R:N422	62.4512	13.62	No	No	0	9	9
6	R:R:D58	R:R:N422	58.8715	10.77	Yes	No	2	9	9
7	R:R:D58	R:R:N30	54.9299	12.12	Yes	Yes	0	9	9
8	R:R:N30	R:R:T26	17.8522	4.39	Yes	No	0	9	9
9	R:R:A62	R:R:T26	10.6125	3.36	No	No	0	9	9
10	R:R:N30	R:R:P423	36.2675	11.4	Yes	No	0	9	9
11	R:R:P423	R:R:V33	32.4408	1.77	No	No	0	9	9
12	R:R:T427	R:R:V33	31.1423	3.17	No	No	0	9	9
13	R:R:F433	R:R:T427	21.8973	3.89	Yes	No	0	9	9
14	R:R:F380	R:R:W384	73.351	7.02	Yes	Yes	1	9	9
15	R:R:F380	R:R:M188	80.1655	6.22	Yes	Yes	1	9	9
16	R:R:M188	R:R:S107	44.4725	4.6	Yes	No	1	9	9
17	R:R:S107	R:R:V191	46.3227	4.85	No	No	0	9	9
18	R:R:V191	R:R:Y111	44.3921	6.31	No	Yes	0	9	9
19	R:R:W112	R:R:Y111	26.8099	4.82	No	Yes	0	7	9
20	R:R:W112	R:R:Y120	24.5461	15.43	No	Yes	0	7	9
21	R:R:R124	R:R:Y120	15.8469	13.38	Yes	Yes	5	8	9
22	R:R:Q47	R:R:R124	10.6068	11.68	No	Yes	0	9	8
23	R:R:M188	R:R:Y192	35.0724	3.59	Yes	Yes	1	9	9
24	R:R:V376	R:R:Y192	34.3542	5.05	No	Yes	0	9	9
25	R:R:V376	R:R:Y426	30.0391	3.79	No	Yes	0	9	9
26	R:R:R110	R:R:Y426	23.4314	8.23	No	Yes	0	9	9
27	R:R:I106	R:R:R110	22.5293	5.01	No	No	0	9	9
28	R:R:F50	R:R:I106	21.5698	3.77	Yes	No	0	9	9
29	R:R:F50	R:R:I133	13.7497	2.51	Yes	No	0	9	9
30	R:R:H102	R:R:I133	10.7332	3.98	Yes	No	6	9	9
31	R:R:I65	R:R:Y416	36.4629	3.63	Yes	Yes	1	9	8
32	R:R:I65	R:R:L64	24.7587	2.85	Yes	No	0	9	6
33	R:R:F95	R:R:L64	17.45	4.87	Yes	No	0	8	6
34	R:R:I65	R:R:Y88	45.2367	8.46	Yes	Yes	0	9	8
35	R:R:S69	R:R:Y416	24.1841	7.63	No	Yes	0	8	8
36	R:R:S69	R:R:Y88	23.1671	5.09	No	Yes	0	8	8
37	R:R:F68	R:R:Y88	26.017	5.16	No	Yes	0	7	8
38	R:R:F68	R:R:F80	22.3339	3.22	No	No	0	7	8
39	R:R:W78	R:R:Y88	39.9448	5.79	Yes	Yes	0	9	8
40	R:R:F80	R:R:Y79	18.6394	14.44	No	No	0	8	5
41	R:R:Y77	R:R:Y79	11.2158	9.93	No	No	0	4	5
42	R:R:C85	R:R:W78	10.8194	3.92	No	Yes	3	9	9
43	R:R:C164	R:R:W78	10.8194	13.06	No	Yes	3	9	9
44	L:L:?1	R:R:S180	19.9552	6.13	Yes	No	1	0	9
45	R:R:S176	R:R:S180	18.5992	1.63	No	No	0	9	9
46	R:R:S176	R:R:Y172	17.0823	13.99	No	Yes	0	9	8
47	R:R:F181	R:R:W384	13.8589	4.01	Yes	Yes	1	9	9
48	R:R:F181	R:R:F385	11.7444	6.43	Yes	Yes	0	9	8
49	R:R:I195	R:R:Y111	20.4436	2.42	No	Yes	0	9	9
50	R:R:I195	R:R:L373	19.0071	2.85	No	No	0	9	9
51	R:R:L373	R:R:Y196	17.6971	3.52	No	Yes	0	9	8
52	R:R:F369	R:R:Y196	11.9685	4.13	No	Yes	0	9	8
53	L:L:?1	R:R:F387	12.5661	11.93	Yes	Yes	1	0	9
54	R:R:D92	R:R:I65	33.3142	7	No	Yes	1	9	9
55	L:L:?1	R:R:D92	34.1703	9.97	Yes	No	1	0	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D92	R:R:I65	7	1	No	Yes	9	9	1	2
R:R:I65	R:R:Y416	3.63	1	Yes	Yes	9	8	2	1
R:R:S69	R:R:Y416	7.63	0	No	Yes	8	8	2	1
R:R:D92	R:R:Y416	8.05	1	No	Yes	9	8	1	1
L:L:?1	R:R:D92	9.97	1	Yes	No	0	9	0	1
L:L:?1	R:R:V93	3.65	1	Yes	No	0	9	0	1
L:L:?1	R:R:C96	9.07	1	Yes	No	0	9	0	1
R:R:I143	R:R:T97	6.08	0	No	No	8	9	2	1
R:R:S180	R:R:T97	7.99	1	No	No	9	9	1	1
L:L:?1	R:R:T97	3.61	1	Yes	No	0	9	0	1
R:R:F380	R:R:I100	3.77	1	Yes	No	9	9	2	2
R:R:I100	R:R:W384	8.22	1	No	Yes	9	9	2	1
R:R:I173	R:R:Y391	13.3	0	No	No	8	8	2	1
R:R:S177	R:R:Y391	5.09	1	No	No	8	8	2	1
L:L:?1	R:R:S180	6.13	1	Yes	No	0	9	0	1
R:R:F181	R:R:F380	5.36	1	Yes	Yes	9	9	2	2
R:R:F181	R:R:W384	4.01	1	Yes	Yes	9	9	2	1
R:R:F181	R:R:F388	24.65	1	Yes	No	9	9	2	1
R:R:F380	R:R:W384	7.02	1	Yes	Yes	9	9	2	1
R:R:F388	R:R:W384	7.02	1	No	Yes	9	9	1	1
R:R:G415	R:R:W384	4.22	0	No	Yes	9	9	2	1
R:R:N418	R:R:W384	9.04	0	No	Yes	9	9	2	1
L:L:?1	R:R:W384	4.65	1	Yes	Yes	0	9	0	1
R:R:F387	R:R:F408	7.5	1	Yes	No	9	7	1	2
R:R:F387	R:R:F411	3.22	1	Yes	Yes	9	7	1	2
R:R:F387	R:R:F412	8.57	1	Yes	No	9	8	1	1
L:L:?1	R:R:F387	11.93	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F388	3.98	1	Yes	No	0	9	0	1
L:L:?1	R:R:Y391	10.52	1	Yes	No	0	8	0	1
R:R:F412	R:R:Y416	14.44	1	No	Yes	8	8	1	1
L:L:?1	R:R:F412	14.91	1	Yes	No	0	8	0	1
R:R:W413	R:R:Y416	7.72	0	No	Yes	9	8	2	1
L:L:?1	R:R:Y416	5.74	1	Yes	Yes	0	8	0	1
R:R:S176	R:R:S180	1.63	0	No	No	9	9	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6K42_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	238
Number of Links	254
Number of Hubs	26
Number of Links mediated by Hubs	112
Number of Communities	7
Number of Nodes involved in Communities	39
Number of Links involved in Communities	51

Path Summary
Number Of Nodes in MetaPath	56
Number Of Links MetaPath	55
Number of Shortest Paths	35447
Length Of Smallest Path	3
Average Path Length	12.2829
Length of Longest Path	28
Minimum Path Strength	1.32
Average Path Strength	6.42632
Maximum Path Strength	17.91
Minimum Path Correlation	0.7
Average Path Correlation	0.92026
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	48.4925
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.9027
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CZX
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	CZX
Name	Dexmedetomidine
Synonyms	dexemedetomidine
Identifier
Formula	C13 H16 N2
Molecular Weight	200.28
SMILES
PubChem	5311068
Formal Charge	0
Total Atoms	31
Total Chiral Atoms	1
Total Bonds	32
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P18089
Sequence	>6K42_nogp_Chain_R A T A A I A A A I T F L I L F T I F G N A L V I L A V L T S R S L R A P Q N L F L V S L A A A D I L V A T L I I P F S L A N E L L G Y W Y F R R T W C E V Y L A L D V L F C T S S I V H L C A I S L D R Y W A V S R A L E Y N S K R T P R R I K C I I L T V W L I A A V I S L P P L I Y K P Q C K L N Q E A W Y I L A S S I G S F F A P C L I M I L V Y L R I Y L I A K R S N R R R R A Q L T R E K R F T F V L A V V I G V F V L C W F P F F F S Y S L G A I C P C K V P H G L F Q F F F W I G Y C N S S L N P V I Y T I F N Q D F R R A F R R I L C R P W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6K41	A	Amine	Adrenergic	α_2b	Homo sapiens	Dexmedetomidine	-	Go/β1/γ2	2.9	2020-04-15	doi.org/10.1038/s41589-020-0492-2
	6K41 (No Gprot)	A	Amine	Adrenergic	α_2b	Homo sapiens	Dexmedetomidine	-		2.9	2020-04-15	doi.org/10.1038/s41589-020-0492-2
	6K42	A	Amine	Adrenergic	α_2b	Homo sapiens	Dexmedetomidine	-	Gi1/β1/γ2	4.1	2020-04-15	doi.org/10.1038/s41589-020-0492-2
	6K42 (No Gprot)	A	Amine	Adrenergic	α_2b	Homo sapiens	Dexmedetomidine	-		4.1	2020-04-15	doi.org/10.1038/s41589-020-0492-2

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6K42_nogp.zip

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