psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A16	R:R:L70	4.73	No	No	0	7	8
2	R:R:A16	R:R:L74	3.15	No	No	0	7	8
3	R:R:I19	R:R:L70	2.85	No	No	0	7	8
4	R:R:I19	R:R:W413	7.05	No	No	0	7	9
5	R:R:L22	R:R:S420	4.5	No	No	0	8	8
6	R:R:I23	R:R:I27	2.94	No	No	0	8	7
7	R:R:I23	R:R:I66	5.89	No	No	0	8	8
8	R:R:F25	R:R:S420	6.61	No	No	0	5	8
9	R:R:N30	R:R:T26	4.39	Yes	No	0	9	9
10	R:R:A62	R:R:T26	3.36	No	No	0	9	9
11	R:R:S420	R:R:T26	3.2	No	No	0	8	9
12	R:R:G29	R:R:P423	4.06	No	No	0	9	9
13	R:R:A55	R:R:N30	4.69	No	Yes	0	9	9
14	R:R:D58	R:R:N30	12.12	Yes	Yes	0	9	9
15	R:R:N30	R:R:P423	11.4	Yes	No	0	9	9
16	R:R:F437	R:R:L32	3.65	No	No	0	9	9
17	R:R:I440	R:R:L32	2.85	No	No	0	8	9
18	R:R:T427	R:R:V33	3.17	No	No	0	9	9
19	R:R:I34	R:R:L38	2.85	No	No	0	8	6
20	R:R:A55	R:R:I34	3.25	No	No	0	9	8
21	R:R:L35	R:R:T39	2.95	No	No	0	6	8
22	R:R:I440	R:R:L35	2.85	No	No	0	8	6
23	R:R:N48	R:R:V37	2.96	No	No	0	9	9
24	R:R:V37	R:R:V52	4.81	No	No	0	9	8
25	R:R:L43	R:R:S40	7.51	No	No	0	9	8
26	R:R:R41	R:R:R44	7.46	No	No	0	8	8
27	R:R:D432	R:R:S42	10.31	No	No	0	9	7
28	R:R:L43	R:R:N48	5.49	No	No	4	9	9
29	R:R:F433	R:R:L43	12.18	Yes	No	4	9	9
30	R:R:A45	R:R:Q47	4.55	No	No	0	8	9
31	R:R:P46	R:R:Q47	3.16	No	No	0	8	9
32	R:R:P126	R:R:P46	7.79	No	No	0	7	8
33	R:R:Q47	R:R:R124	11.68	No	Yes	0	9	8
34	R:R:F433	R:R:N48	6.04	Yes	No	4	9	9
35	R:R:I129	R:R:L49	5.71	No	No	0	9	8
36	R:R:F50	R:R:I106	3.77	Yes	No	0	9	9
37	R:R:D109	R:R:F50	4.78	No	Yes	0	9	9
38	R:R:F50	R:R:I129	6.28	Yes	No	0	9	9
39	R:R:F50	R:R:I132	6.28	Yes	No	0	9	7
40	R:R:F433	R:R:L51	3.65	Yes	No	0	9	8
41	R:R:H102	R:R:S53	6.97	Yes	No	6	9	9
42	R:R:I133	R:R:S53	7.74	No	No	6	9	9
43	R:R:D58	R:R:L54	4.07	Yes	No	2	9	9
44	R:R:L54	R:R:S99	3	No	No	2	9	9
45	R:R:L54	R:R:N422	6.87	No	No	2	9	9
46	R:R:D58	R:R:S99	2.94	Yes	No	2	9	9
47	R:R:D58	R:R:S419	8.83	Yes	No	0	9	9
48	R:R:D58	R:R:N422	10.77	Yes	No	2	9	9
49	R:R:I59	R:R:T63	3.04	No	No	0	8	6
50	R:R:F95	R:R:L60	10.96	Yes	No	0	8	8
51	R:R:S419	R:R:V61	6.46	No	No	0	9	9
52	R:R:L64	R:R:T63	2.95	No	No	0	6	6
53	R:R:I65	R:R:L64	2.85	Yes	No	0	9	6
54	R:R:F95	R:R:L64	4.87	Yes	No	0	8	6
55	R:R:I65	R:R:Y88	8.46	Yes	Yes	0	9	8
56	R:R:D92	R:R:I65	7	No	Yes	1	9	9
57	R:R:I65	R:R:Y416	3.63	Yes	Yes	1	9	8
58	R:R:I66	R:R:P67	3.39	No	No	0	8	9
59	R:R:F68	R:R:F80	3.22	No	No	0	7	8
60	R:R:F68	R:R:Y88	5.16	No	Yes	0	7	8
61	R:R:S69	R:R:Y88	5.09	No	Yes	0	8	8
62	R:R:S69	R:R:Y416	7.63	No	Yes	0	8	8
63	R:R:N72	R:R:W78	3.39	No	Yes	0	7	9
64	R:R:E73	R:R:Q409	6.37	No	No	0	8	5
65	R:R:E73	R:R:W413	4.36	No	No	0	8	9
66	R:R:L75	R:R:Y77	4.69	No	No	0	6	4
67	R:R:Y77	R:R:Y79	9.93	No	No	0	4	5
68	R:R:C85	R:R:W78	3.92	No	Yes	3	9	9
69	R:R:W78	R:R:Y88	5.79	Yes	Yes	0	9	8
70	R:R:C164	R:R:W78	13.06	No	Yes	3	9	9
71	R:R:F80	R:R:Y79	14.44	No	No	0	8	5
72	R:R:R81	R:R:W84	23.99	No	No	0	8	5
73	R:R:C85	R:R:L89	3.17	No	No	3	9	8
74	R:R:C164	R:R:C85	7.28	No	No	3	9	9
75	R:R:C164	R:R:L89	3.17	No	No	3	9	8
76	R:R:L166	R:R:L89	4.15	No	No	0	7	8
77	R:R:F95	R:R:L91	6.09	Yes	No	0	8	7
78	R:R:D92	R:R:Y416	8.05	No	Yes	1	9	8
79	L:L:?1	R:R:D92	9.97	Yes	No	1	0	9
80	L:L:?1	R:R:V93	3.65	Yes	No	0	0	9
81	R:R:F95	R:R:L94	6.09	Yes	No	0	8	8
82	R:R:L94	R:R:S144	10.51	No	No	0	8	9
83	L:L:?1	R:R:C96	9.07	Yes	No	0	0	9
84	R:R:I143	R:R:T97	6.08	No	No	0	8	9
85	R:R:S180	R:R:T97	7.99	No	No	1	9	9
86	L:L:?1	R:R:T97	3.61	Yes	No	1	0	9
87	R:R:S98	R:R:W137	12.36	No	No	0	9	9
88	R:R:I100	R:R:P184	3.39	No	No	0	9	9
89	R:R:F380	R:R:I100	3.77	Yes	No	1	9	9
90	R:R:I100	R:R:W384	8.22	No	Yes	1	9	9
91	R:R:V101	R:R:V136	4.81	No	No	0	8	9
92	R:R:H102	R:R:I133	3.98	Yes	No	6	9	9
93	R:R:H102	R:R:V136	6.92	Yes	No	0	9	9
94	R:R:H102	R:R:W137	10.58	Yes	No	0	9	9
95	R:R:L103	R:R:Y426	3.52	No	Yes	0	9	9
96	R:R:C104	R:R:P184	3.77	No	No	0	8	9
97	R:R:C104	R:R:M188	3.24	No	Yes	0	8	9
98	R:R:I106	R:R:R110	5.01	No	No	0	9	9
99	R:R:M188	R:R:S107	4.6	Yes	No	1	9	9
100	R:R:S107	R:R:V191	4.85	No	No	0	9	9
101	R:R:S107	R:R:Y192	11.45	No	Yes	1	9	9
102	R:R:L108	R:R:W112	15.94	No	No	0	7	7
103	R:R:D109	R:R:Y120	4.6	No	Yes	5	9	9
104	R:R:D109	R:R:R124	13.1	No	Yes	5	9	8
105	R:R:R110	R:R:Y426	8.23	No	Yes	0	9	9
106	R:R:W112	R:R:Y111	4.82	No	Yes	0	7	9
107	R:R:S115	R:R:Y111	10.17	No	Yes	0	9	9
108	R:R:V191	R:R:Y111	6.31	No	Yes	0	9	9
109	R:R:R194	R:R:Y111	8.23	No	Yes	0	7	9
110	R:R:W112	R:R:Y120	15.43	No	Yes	0	7	9
111	R:R:A113	R:R:R124	4.15	No	Yes	0	9	8
112	R:R:I198	R:R:V114	4.61	No	No	0	8	9
113	R:R:E119	R:R:R116	8.14	No	No	0	6	7
114	R:R:R116	R:R:Y120	13.38	No	Yes	0	7	9
115	R:R:R124	R:R:Y120	13.38	Yes	Yes	5	8	9
116	R:R:L145	R:R:P146	3.28	No	No	0	7	8
117	R:R:I149	R:R:L145	8.56	No	No	0	6	7
118	R:R:P146	R:R:P147	5.84	No	No	7	8	8
119	R:R:P146	R:R:Y172	9.74	No	Yes	7	8	8
120	R:R:P147	R:R:Y172	6.95	No	Yes	7	8	8
121	R:R:W171	R:R:Y150	6.75	No	No	0	5	6
122	R:R:K165	R:R:Q163	5.42	No	No	0	4	4
123	R:R:Q168	R:R:Y172	5.64	No	Yes	0	6	8
124	R:R:E169	R:R:W171	4.36	No	No	0	7	5
125	R:R:W171	R:R:Y172	6.75	No	Yes	0	5	8
126	R:R:S176	R:R:Y172	13.99	No	Yes	0	9	8
127	R:R:I173	R:R:Y391	13.3	No	No	0	8	8
128	R:R:A395	R:R:L174	3.15	No	No	0	8	7
129	R:R:F182	R:R:S177	5.28	Yes	No	1	8	8
130	R:R:S177	R:R:Y391	5.09	No	No	0	8	8
131	R:R:S177	R:R:S392	4.89	No	No	1	8	8
132	R:R:G179	R:R:I178	3.53	No	No	0	7	7
133	R:R:F182	R:R:I178	3.77	Yes	No	0	8	7
134	L:L:?1	R:R:S180	6.13	Yes	No	1	0	9
135	R:R:F181	R:R:F182	6.43	Yes	Yes	1	9	8
136	R:R:C185	R:R:F181	11.17	No	Yes	0	8	9
137	R:R:F181	R:R:F380	5.36	Yes	Yes	1	9	9
138	R:R:F181	R:R:W384	4.01	Yes	Yes	1	9	9
139	R:R:F181	R:R:F385	6.43	Yes	Yes	0	9	8
140	R:R:F181	R:R:F388	24.65	Yes	No	1	9	9
141	R:R:F182	R:R:S392	6.61	Yes	No	1	8	8
142	R:R:C185	R:R:I189	3.27	No	No	0	8	6
143	R:R:M188	R:R:Y192	3.59	Yes	Yes	1	9	9
144	R:R:F380	R:R:M188	6.22	Yes	Yes	1	9	9
145	R:R:I189	R:R:I377	2.94	No	No	0	6	8
146	R:R:V376	R:R:Y192	5.05	No	Yes	0	9	9
147	R:R:I377	R:R:Y192	3.63	No	Yes	0	8	9
148	R:R:I195	R:R:L373	2.85	No	No	0	9	9
149	R:R:K200	R:R:Y196	8.36	No	Yes	0	7	8
150	R:R:F369	R:R:Y196	4.13	No	Yes	0	9	8
151	R:R:T370	R:R:Y196	7.49	No	Yes	0	9	8
152	R:R:L373	R:R:Y196	3.52	No	Yes	0	9	8
153	R:R:A199	R:R:F369	5.55	No	No	0	9	9
154	R:R:N203	R:R:Q362	13.2	No	No	0	5	5
155	R:R:E366	R:R:F369	3.5	No	No	0	9	9
156	R:R:F371	R:R:V375	7.87	No	No	0	7	9
157	R:R:F429	R:R:V372	11.8	No	No	0	8	9
158	R:R:V376	R:R:Y426	3.79	No	Yes	0	9	9
159	R:R:I425	R:R:V379	3.07	No	No	0	9	8
160	R:R:F380	R:R:W384	7.02	Yes	Yes	1	9	9
161	R:R:C383	R:R:N418	3.15	No	No	0	9	9
162	R:R:F388	R:R:W384	7.02	No	Yes	1	9	9
163	R:R:G415	R:R:W384	4.22	No	Yes	0	9	9
164	R:R:N418	R:R:W384	9.04	No	Yes	0	9	9
165	L:L:?1	R:R:W384	4.65	Yes	Yes	1	0	9
166	R:R:F385	R:R:P386	4.33	Yes	No	0	8	9
167	R:R:F411	R:R:P386	10.11	Yes	No	0	7	9
168	R:R:F387	R:R:F408	7.5	Yes	No	0	9	7
169	R:R:F387	R:R:F411	3.22	Yes	Yes	0	9	7
170	R:R:F387	R:R:F412	8.57	Yes	No	1	9	8
171	L:L:?1	R:R:F387	11.93	Yes	Yes	1	0	9
172	L:L:?1	R:R:F388	3.98	Yes	No	1	0	9
173	R:R:F389	R:R:L393	3.65	No	No	0	8	7
174	R:R:F411	R:R:S390	3.96	Yes	No	0	7	8
175	L:L:?1	R:R:Y391	10.52	Yes	No	0	0	8
176	R:R:F411	R:R:L407	3.65	Yes	No	0	7	7
177	R:R:F408	R:R:Q409	4.68	No	No	0	7	5
178	R:R:F410	R:R:I414	6.28	No	No	0	7	9
179	R:R:F412	R:R:Y416	14.44	No	Yes	1	8	8
180	L:L:?1	R:R:F412	14.91	Yes	No	1	0	8
181	R:R:W413	R:R:Y416	7.72	No	Yes	0	9	8
182	L:L:?1	R:R:Y416	5.74	Yes	Yes	1	0	8
183	R:R:N418	R:R:N422	13.62	No	No	0	9	9
184	R:R:I425	R:R:Y426	4.84	No	Yes	0	9	9
185	R:R:F433	R:R:T427	3.89	Yes	No	0	9	9
186	R:R:F437	R:R:T427	6.49	No	No	0	9	9
187	R:R:F429	R:R:I428	3.77	No	No	0	8	7
188	R:R:D432	R:R:N430	8.08	No	No	0	9	9
189	R:R:F433	R:R:N430	7.25	Yes	No	0	9	9
190	R:R:A436	R:R:R439	4.15	No	No	0	9	7
191	R:R:I440	R:R:L441	2.85	No	No	0	8	9
192	R:R:K130	R:R:L49	2.82	No	No	0	6	8
193	R:R:W78	R:R:W84	2.81	Yes	No	0	9	5
194	R:R:C131	R:R:R127	2.79	No	No	0	4	6
195	R:R:A105	R:R:F50	2.77	No	Yes	0	8	9
196	R:R:A71	R:R:Y79	2.67	No	No	0	7	5
197	R:R:R439	R:R:S40	2.64	No	No	0	7	8
198	R:R:F25	R:R:V424	2.62	No	No	0	5	7
199	R:R:F385	R:R:V381	2.62	Yes	No	0	8	8
200	R:R:A57	R:R:W137	2.59	No	No	0	9	9
201	R:R:F50	R:R:I133	2.51	Yes	No	0	9	9
202	R:R:I132	R:R:R128	2.51	No	No	0	7	8
203	R:R:I195	R:R:Y111	2.42	No	Yes	0	9	9
204	R:R:N203	R:R:R365	2.41	No	No	0	5	8
205	R:R:Q431	R:R:R434	2.34	No	No	0	4	9
206	R:R:F410	R:R:F411	2.14	No	Yes	0	7	7
207	R:R:C397	R:R:P398	1.88	No	No	0	8	4
208	R:R:A90	R:R:P147	1.87	No	No	0	9	8
209	R:R:A183	R:R:P184	1.87	No	No	0	7	9
210	R:R:C383	R:R:C417	1.82	No	No	0	9	7
211	R:R:C397	R:R:C401	1.82	No	No	0	8	5
212	R:R:A36	R:R:A436	1.79	No	No	0	9	9
213	R:R:P423	R:R:V33	1.77	No	No	0	9	9
214	R:R:P404	R:R:V403	1.77	No	No	0	8	6
215	R:R:G378	R:R:I377	1.76	No	No	0	8	8
216	R:R:P126	R:R:T125	1.75	No	No	0	7	9
217	R:R:A140	R:R:S98	1.71	No	No	0	9	9
218	R:R:A141	R:R:S144	1.71	No	No	0	7	9
219	R:R:A113	R:R:V114	1.7	No	No	0	9	9
220	R:R:A11	R:R:T12	1.68	No	No	0	6	6
221	R:R:C397	R:R:I396	1.64	No	No	0	8	7
222	R:R:S176	R:R:S180	1.63	No	No	0	9	9
223	R:R:A62	R:R:I66	1.62	No	No	0	9	8
224	R:R:A395	R:R:I173	1.62	No	No	0	8	8
225	R:R:V372	R:R:V376	1.6	No	No	0	9	9
226	R:R:V375	R:R:V379	1.6	No	No	0	9	8
227	R:R:C383	R:R:L421	1.59	No	No	0	9	7
228	R:R:A13	R:R:L74	1.58	No	No	0	7	8
229	R:R:A90	R:R:L148	1.58	No	No	0	9	9
230	R:R:I187	R:R:V191	1.54	No	No	0	8	9
231	R:R:I139	R:R:T135	1.52	No	No	0	7	5
232	R:R:F28	R:R:G29	1.51	No	No	0	6	9
233	R:R:L91	R:R:V87	1.49	No	No	0	7	7
234	R:R:L70	R:R:T20	1.47	No	No	0	8	6
235	R:R:P444	R:R:R443	1.44	No	No	0	5	6
236	R:R:I27	R:R:L24	1.43	No	No	0	7	5
237	R:R:I189	R:R:L193	1.43	No	No	0	6	4
238	R:R:P162	R:R:Y77	1.39	No	No	0	3	4
239	R:R:C442	R:R:R443	1.39	No	No	0	5	6
240	R:R:L186	R:R:L190	1.38	No	No	0	5	5
241	R:R:E119	R:R:K123	1.35	No	No	0	6	6
242	R:R:P444	R:R:W445	1.35	No	No	0	5	4
243	R:R:E366	R:R:L363	1.33	No	No	0	9	5
244	R:R:N430	R:R:Q431	1.32	No	No	0	9	4
245	R:R:E366	R:R:N203	1.31	No	No	0	9	5
246	R:R:R127	R:R:T125	1.29	No	No	0	6	9
247	R:R:I198	R:R:R201	1.25	No	No	0	8	6
248	R:R:H405	R:R:Q409	1.24	No	No	0	5	5
249	R:R:F21	R:R:L24	1.22	No	No	0	5	5
250	R:R:L197	R:R:Y196	1.17	No	Yes	0	5	8
251	R:R:Q362	R:R:R204	1.17	No	No	0	5	7
252	R:R:R358	R:R:R359	1.07	No	No	0	6	5
253	R:R:F385	R:R:F389	1.07	Yes	No	0	8	8
254	R:R:R82	R:R:W78	1	No	Yes	0	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N30	8.15	4	0	9
2	R:R:F50	4.39833	6	0	9
3	R:R:D58	7.746	5	2	9
4	R:R:I65	5.485	4	1	9
5	R:R:W78	4.995	6	3	9
6	R:R:Y88	6.125	4	0	8
7	R:R:F95	7.0025	4	0	8
8	R:R:H102	7.1125	4	6	9
9	R:R:Y111	6.39	5	0	9
10	R:R:Y120	11.6975	4	5	9
11	R:R:R124	10.5775	4	5	8
12	R:R:Y172	8.614	5	7	8
13	R:R:F181	9.675	6	1	9
14	R:R:F182	5.5225	4	1	8
15	R:R:M188	4.4125	4	1	9
16	R:R:Y192	5.93	4	1	9
17	R:R:Y196	4.934	5	0	8
18	R:R:F380	5.5925	4	1	9
19	R:R:W384	6.31143	7	1	9
20	R:R:F385	3.6125	4	0	8
21	R:R:F387	7.805	4	1	9
22	R:R:F411	4.616	5	0	7
23	R:R:Y416	7.86833	6	1	8
24	R:R:Y426	5.095	4	0	9
25	R:R:F433	6.602	5	4	9
26	L:L:?1	7.65091	11	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:W413	R:R:Y416	11.8593	7.72	No	Yes	0	9	8
2	L:L:?1	R:R:Y416	64.6231	5.74	Yes	Yes	1	0	8
3	L:L:?1	R:R:W384	100	4.65	Yes	Yes	1	0	9
4	R:R:N418	R:R:W384	66.3583	9.04	No	Yes	0	9	9
5	R:R:N418	R:R:N422	62.4512	13.62	No	No	0	9	9
6	R:R:D58	R:R:N422	58.8715	10.77	Yes	No	2	9	9
7	R:R:D58	R:R:N30	54.9299	12.12	Yes	Yes	0	9	9
8	R:R:N30	R:R:T26	17.8522	4.39	Yes	No	0	9	9
9	R:R:A62	R:R:T26	10.6125	3.36	No	No	0	9	9
10	R:R:N30	R:R:P423	36.2675	11.4	Yes	No	0	9	9
11	R:R:P423	R:R:V33	32.4408	1.77	No	No	0	9	9
12	R:R:T427	R:R:V33	31.1423	3.17	No	No	0	9	9
13	R:R:F433	R:R:T427	21.8973	3.89	Yes	No	0	9	9
14	R:R:F380	R:R:W384	73.351	7.02	Yes	Yes	1	9	9
15	R:R:F380	R:R:M188	80.1655	6.22	Yes	Yes	1	9	9
16	R:R:M188	R:R:S107	44.4725	4.6	Yes	No	1	9	9
17	R:R:S107	R:R:V191	46.3227	4.85	No	No	0	9	9
18	R:R:V191	R:R:Y111	44.3921	6.31	No	Yes	0	9	9
19	R:R:W112	R:R:Y111	26.8099	4.82	No	Yes	0	7	9
20	R:R:W112	R:R:Y120	24.5461	15.43	No	Yes	0	7	9
21	R:R:R124	R:R:Y120	15.8469	13.38	Yes	Yes	5	8	9
22	R:R:Q47	R:R:R124	10.6068	11.68	No	Yes	0	9	8
23	R:R:M188	R:R:Y192	35.0724	3.59	Yes	Yes	1	9	9
24	R:R:V376	R:R:Y192	34.3542	5.05	No	Yes	0	9	9
25	R:R:V376	R:R:Y426	30.0391	3.79	No	Yes	0	9	9
26	R:R:R110	R:R:Y426	23.4314	8.23	No	Yes	0	9	9
27	R:R:I106	R:R:R110	22.5293	5.01	No	No	0	9	9
28	R:R:F50	R:R:I106	21.5698	3.77	Yes	No	0	9	9
29	R:R:F50	R:R:I133	13.7497	2.51	Yes	No	0	9	9
30	R:R:H102	R:R:I133	10.7332	3.98	Yes	No	6	9	9
31	R:R:I65	R:R:Y416	36.4629	3.63	Yes	Yes	1	9	8
32	R:R:I65	R:R:L64	24.7587	2.85	Yes	No	0	9	6
33	R:R:F95	R:R:L64	17.45	4.87	Yes	No	0	8	6
34	R:R:I65	R:R:Y88	45.2367	8.46	Yes	Yes	0	9	8
35	R:R:S69	R:R:Y416	24.1841	7.63	No	Yes	0	8	8
36	R:R:S69	R:R:Y88	23.1671	5.09	No	Yes	0	8	8
37	R:R:F68	R:R:Y88	26.017	5.16	No	Yes	0	7	8
38	R:R:F68	R:R:F80	22.3339	3.22	No	No	0	7	8
39	R:R:W78	R:R:Y88	39.9448	5.79	Yes	Yes	0	9	8
40	R:R:F80	R:R:Y79	18.6394	14.44	No	No	0	8	5
41	R:R:Y77	R:R:Y79	11.2158	9.93	No	No	0	4	5
42	R:R:C85	R:R:W78	10.8194	3.92	No	Yes	3	9	9
43	R:R:C164	R:R:W78	10.8194	13.06	No	Yes	3	9	9
44	L:L:?1	R:R:S180	19.9552	6.13	Yes	No	1	0	9
45	R:R:S176	R:R:S180	18.5992	1.63	No	No	0	9	9
46	R:R:S176	R:R:Y172	17.0823	13.99	No	Yes	0	9	8
47	R:R:F181	R:R:W384	13.8589	4.01	Yes	Yes	1	9	9
48	R:R:F181	R:R:F385	11.7444	6.43	Yes	Yes	0	9	8
49	R:R:I195	R:R:Y111	20.4436	2.42	No	Yes	0	9	9
50	R:R:I195	R:R:L373	19.0071	2.85	No	No	0	9	9
51	R:R:L373	R:R:Y196	17.6971	3.52	No	Yes	0	9	8
52	R:R:F369	R:R:Y196	11.9685	4.13	No	Yes	0	9	8
53	L:L:?1	R:R:F387	12.5661	11.93	Yes	Yes	1	0	9
54	R:R:D92	R:R:I65	33.3142	7	No	Yes	1	9	9
55	L:L:?1	R:R:D92	34.1703	9.97	Yes	No	1	0	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D92	R:R:I65	7	1	No	Yes	9	9	1	2
R:R:I65	R:R:Y416	3.63	1	Yes	Yes	9	8	2	1
R:R:S69	R:R:Y416	7.63	0	No	Yes	8	8	2	1
R:R:D92	R:R:Y416	8.05	1	No	Yes	9	8	1	1
L:L:?1	R:R:D92	9.97	1	Yes	No	0	9	0	1
L:L:?1	R:R:V93	3.65	1	Yes	No	0	9	0	1
L:L:?1	R:R:C96	9.07	1	Yes	No	0	9	0	1
R:R:I143	R:R:T97	6.08	0	No	No	8	9	2	1
R:R:S180	R:R:T97	7.99	1	No	No	9	9	1	1
L:L:?1	R:R:T97	3.61	1	Yes	No	0	9	0	1
R:R:F380	R:R:I100	3.77	1	Yes	No	9	9	2	2
R:R:I100	R:R:W384	8.22	1	No	Yes	9	9	2	1
R:R:I173	R:R:Y391	13.3	0	No	No	8	8	2	1
R:R:S177	R:R:Y391	5.09	1	No	No	8	8	2	1
L:L:?1	R:R:S180	6.13	1	Yes	No	0	9	0	1
R:R:F181	R:R:F380	5.36	1	Yes	Yes	9	9	2	2
R:R:F181	R:R:W384	4.01	1	Yes	Yes	9	9	2	1
R:R:F181	R:R:F388	24.65	1	Yes	No	9	9	2	1
R:R:F380	R:R:W384	7.02	1	Yes	Yes	9	9	2	1
R:R:F388	R:R:W384	7.02	1	No	Yes	9	9	1	1
R:R:G415	R:R:W384	4.22	0	No	Yes	9	9	2	1
R:R:N418	R:R:W384	9.04	0	No	Yes	9	9	2	1
L:L:?1	R:R:W384	4.65	1	Yes	Yes	0	9	0	1
R:R:F387	R:R:F408	7.5	1	Yes	No	9	7	1	2
R:R:F387	R:R:F411	3.22	1	Yes	Yes	9	7	1	2
R:R:F387	R:R:F412	8.57	1	Yes	No	9	8	1	1
L:L:?1	R:R:F387	11.93	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F388	3.98	1	Yes	No	0	9	0	1
L:L:?1	R:R:Y391	10.52	1	Yes	No	0	8	0	1
R:R:F412	R:R:Y416	14.44	1	No	Yes	8	8	1	1
L:L:?1	R:R:F412	14.91	1	Yes	No	0	8	0	1
R:R:W413	R:R:Y416	7.72	0	No	Yes	9	8	2	1
L:L:?1	R:R:Y416	5.74	1	Yes	Yes	0	8	0	1
R:R:S176	R:R:S180	1.63	0	No	No	9	9	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6K42_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	238
Number of Links	254
Number of Hubs	26
Number of Links mediated by Hubs	112
Number of Communities	7
Number of Nodes involved in Communities	39
Number of Links involved in Communities	51

Path Summary
Number Of Nodes in MetaPath	56
Number Of Links MetaPath	55
Number of Shortest Paths	35447
Length Of Smallest Path	3
Average Path Length	12.2829
Length of Longest Path	28
Minimum Path Strength	1.32
Average Path Strength	6.42632
Maximum Path Strength	17.91
Minimum Path Correlation	0.7
Average Path Correlation	0.92026
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	48.4925
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.9027
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cation binding • magnesium ion binding • ion binding • binding • metal ion binding • small molecule binding • guanyl nucleotide binding • nucleotide binding • GDP binding • guanyl ribonucleotide binding • purine ribonucleotide binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • G protein-coupled serotonin receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • GTP binding • purine ribonucleoside triphosphate binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • regulation of cytoskeleton organization • regulation of cellular component organization • regulation of cellular process • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of biological process
Gene Ontology	Biological Process	• regulation of cytoskeleton organization • regulation of cellular component organization • regulation of cellular process • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of biological process • regulation of cell cycle process • biological regulation • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • cellular process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • regulation of protein localization • positive regulation of biological process • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of protein localization to cell cortex • macromolecule localization • positive regulation of protein localization • intracellular protein localization • protein localization to cell cortex • cell division • cellular response to stimulus • response to stimulus • signaling • G protein-coupled receptor signaling pathway • signal transduction • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to lipid • response to alcohol • cellular response to forskolin • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to chemical • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • cell periphery • cell cortex • intracellular anatomical structure • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • cell periphery • cell cortex • intracellular anatomical structure • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • intracellular organelle • centrosome • microtubule organizing center • cytoskeleton • organelle • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • membrane-bounded organelle • nucleus • intracellular membrane-bounded organelle • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • response to external stimulus • detection of abiotic stimulus • detection of stimulus • response to radiation • phototransduction, visible light • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • myelin sheath • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • thioesterase binding • adrenergic receptor binding • signaling receptor binding • alpha-1B adrenergic receptor binding • G protein-coupled receptor binding • alpha-adrenergic receptor activity • G protein-coupled amine receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • adrenergic receptor activity • alpha2-adrenergic receptor activity • protein heterodimerization activity • protein dimerization activity • heterotrimeric G-protein binding • identical protein binding • protein homodimerization activity • kinase binding • protein kinase binding • alpha-2C adrenergic receptor binding • cation binding • ion binding • catecholamine binding • norepinephrine binding • small molecule binding • GTPase regulator activity • enzyme regulator activity • guanyl-nucleotide exchange factor activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • epinephrine binding • hormone binding • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • cell-cell signaling • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • positive regulation of response to wounding • wound healing • positive regulation of biological process • regulation of response to wounding • positive regulation of response to stimulus • positive regulation of wound healing • regulation of response to stimulus • regulation of response to stress • regulation of wound healing • response to wounding • phospholipase C-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting adrenergic receptor signaling pathway • thermoception • sensory perception of temperature stimulus • digestion • intestinal absorption • digestive system process • regulation of tube diameter • regulation of tube size • regulation of system process • circulatory system process • regulation of blood circulation • regulation of vasoconstriction • vascular process in circulatory system • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • blood circulation • vasoconstriction • regulation of anatomical structure size • cellular component organization • organelle organization • actin cytoskeleton organization • actin filament-based process • cellular component organization or biogenesis • cytoskeleton organization • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • cell surface receptor protein tyrosine kinase signaling pathway • positive regulation of ERBB signaling pathway • regulation of epidermal growth factor receptor signaling pathway • epidermal growth factor receptor signaling pathway • enzyme-linked receptor protein signaling pathway • positive regulation of cellular process • positive regulation of epidermal growth factor receptor signaling pathway • regulation of ERBB signaling pathway • cell surface receptor signaling pathway • ERBB signaling pathway • positive regulation of signaling • fear response • multicellular organismal response to stress • regulation of localization • regulation of calcium ion transport • transport • regulation of transport • negative regulation of monoatomic ion transport • regulation of monoatomic ion transport • negative regulation of biological process • negative regulation of transport • establishment of localization • calcium ion transport • metal ion transport • negative regulation of calcium ion transport • localization • monoatomic ion transport • monoatomic cation transport • regulation of metal ion transport • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of cellular process • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of body fluid levels • cell activation • hemostasis • blood coagulation • coagulation • platelet activation • regulation of potassium ion transport • positive regulation of potassium ion transport • positive regulation of transport • positive regulation of monoatomic ion transport • potassium ion transport • adenylate cyclase-activating adrenergic receptor signaling pathway • response to morphine • response to isoquinoline alkaloid • response to alkaloid • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • metabolic process • regulation of metabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process • positive regulation of protein metabolic process • positive regulation of membrane protein ectodomain proteolysis • macromolecule catabolic process • positive regulation of metabolic process • regulation of proteolysis • proteolysis • membrane protein proteolysis • positive regulation of macromolecule metabolic process • protein metabolic process • membrane protein ectodomain proteolysis • regulation of membrane protein ectodomain proteolysis • regulation of protein metabolic process • regulation of macromolecule metabolic process • protein catabolic process • positive regulation of protein catabolic process • positive regulation of catabolic process • positive regulation of proteolysis • macromolecule metabolic process • regulation of protein catabolic process • small GTPase-mediated signal transduction • Rho protein signal transduction • intracellular signal transduction • intracellular signaling cassette • muscle contraction • muscle system process • regulation of muscle system process • negative regulation of muscle contraction • uterine smooth muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • regulation of uterine smooth muscle contraction • negative regulation of uterine smooth muscle contraction • negative regulation of smooth muscle contraction • negative regulation of multicellular organismal process • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • nucleobase-containing compound metabolic process • DNA replication • DNA metabolic process • nucleic acid metabolic process • multi-multicellular organism process • reproductive process • female pregnancy • multi-organism reproductive process • regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • regulation of intracellular signal transduction • positive regulation of intracellular signal transduction • positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction • phosphatidylinositol 3-kinase/protein kinase B signal transduction • negative regulation of protein transport • establishment of protein localization • nitrogen compound transport • negative regulation of hormone secretion • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • amide transport • signal release • negative regulation of protein localization • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • Ras protein signal transduction • positive regulation of cell population proliferation • regulation of cell population proliferation • vasodilation • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • establishment of localization in cell • intracellular glucose homeostasis • cellular response to carbohydrate stimulus • response to glucose • insulin secretion involved in cellular response to glucose stimulus • cellular localization • response to monosaccharide • response to carbohydrate • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • negative regulation of response to stimulus • negative regulation of insulin secretion involved in cellular response to glucose stimulus • cellular response to glucose stimulus • response to hexose • cellular homeostasis • regulation of cellular localization • regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • monoamine transport • negative regulation of amine transport • regulation of catecholamine secretion • epinephrine secretion • organic hydroxy compound transport • catecholamine transport • epinephrine transport • regulation of epinephrine secretion • negative regulation of catecholamine secretion • organic cation transport • catecholamine secretion • amine transport • negative regulation of epinephrine secretion • regulation of amine transport • positive regulation of macromolecule biosynthetic process • positive regulation of biosynthetic process • cytokine production • regulation of cytokine production • regulation of biosynthetic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • regulation of macromolecule biosynthetic process • positive regulation of cytokine production • negative regulation of norepinephrine secretion • norepinephrine transport • norepinephrine secretion • regulation of norepinephrine secretion • cellular developmental process • regulation of developmental process • regulation of cell differentiation • positive regulation of neuron differentiation • positive regulation of developmental process • neurogenesis • neuron differentiation • positive regulation of cell differentiation • cell differentiation • nervous system development • generation of neurons • regulation of neuron differentiation • regulation of blood pressure • positive regulation of blood pressure • positive regulation of smooth muscle contraction • positive regulation of uterine smooth muscle contraction • positive regulation of muscle contraction • vascular associated smooth muscle contraction • regulation of vascular associated smooth muscle contraction • postsynaptic specialization membrane • postsynaptic specialization • postsynaptic density membrane • synaptic membrane • postsynaptic density • postsynapse • neuron to neuron synapse • postsynaptic membrane • asymmetric synapse • plasma membrane region • basal part of cell • basal plasma membrane • basolateral plasma membrane • dopaminergic synapse • glutamatergic synapse • receptor complex • somatodendritic compartment • cell body • neuronal cell body • GABA-ergic synapse • presynaptic active zone membrane • presynaptic membrane • presynapse • presynaptic active zone • axon • axon terminus • distal axon • neuron projection terminus • cell surface • cytosol
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CZX
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	CZX
Name	Dexmedetomidine
Synonyms	Dexmedetomidinum
Identifier
Formula	C13 H16 N2
Molecular Weight	200.28
SMILES
PubChem	5311068
Formal Charge	0
Total Atoms	31
Total Chiral Atoms	1
Total Bonds	32
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P18089
Sequence	>6K42_nogp_Chain_R A T A A I A A A I T F L I L F T I F G N A L V I L A V L T S R S L R A P Q N L F L V S L A A A D I L V A T L I I P F S L A N E L L G Y W Y F R R T W C E V Y L A L D V L F C T S S I V H L C A I S L D R Y W A V S R A L E Y N S K R T P R R I K C I I L T V W L I A A V I S L P P L I Y K P Q C K L N Q E A W Y I L A S S I G S F F A P C L I M I L V Y L R I Y L I A K R S N R R R R A Q L T R E K R F T F V L A V V I G V F V L C W F P F F F S Y S L G A I C P C K V P H G L F Q F F F W I G Y C N S S L N P V I Y T I F N Q D F R R A F R R I L C R P W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6K41	A	Amine	Adrenergic	α_2b	Homo sapiens	Dexmedetomidine	-	Go/β1/γ2	2.9	2020-04-15	doi.org/10.1038/s41589-020-0492-2
	6K41 (No Gprot)	A	Amine	Adrenergic	α_2b	Homo sapiens	Dexmedetomidine	-		2.9	2020-04-15	doi.org/10.1038/s41589-020-0492-2
	6K42	A	Amine	Adrenergic	α_2b	Homo sapiens	Dexmedetomidine	-	Gi1/β1/γ2	4.1	2020-04-15	doi.org/10.1038/s41589-020-0492-2
	6K42 (No Gprot)	A	Amine	Adrenergic	α_2b	Homo sapiens	Dexmedetomidine	-		4.1	2020-04-15	doi.org/10.1038/s41589-020-0492-2

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