psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L41	R:R:L45	6.92	No	Yes	0	5	7
2	R:R:I96	R:R:L45	4.28	No	Yes	1	6	7
3	R:R:L45	R:R:W343	17.08	Yes	Yes	1	7	7
4	R:R:M92	R:R:T49	9.03	Yes	No	0	8	7
5	R:R:N56	R:R:T52	4.39	Yes	Yes	0	9	8
6	R:R:S88	R:R:T52	3.2	No	Yes	1	7	8
7	R:R:M92	R:R:T52	7.53	Yes	Yes	1	8	8
8	R:R:L350	R:R:T52	10.32	No	Yes	0	6	8
9	R:R:S88	R:R:V53	6.46	No	No	0	7	6
10	R:R:D84	R:R:N56	12.12	Yes	Yes	0	9	9
11	R:R:L85	R:R:N56	4.12	No	Yes	0	7	9
12	R:R:N56	R:R:P353	6.52	Yes	No	0	9	9
13	R:R:F58	R:R:T62	7.78	Yes	Yes	2	8	8
14	R:R:F367	R:R:F58	9.65	Yes	Yes	2	8	8
15	R:R:F58	R:R:I370	6.28	Yes	No	2	8	6
16	R:R:F58	R:R:V371	3.93	Yes	No	0	8	7
17	R:R:P353	R:R:V59	3.53	No	No	0	9	9
18	R:R:T357	R:R:V59	4.76	No	No	0	7	9
19	R:R:L60	R:R:L64	5.54	No	No	0	8	3
20	R:R:L60	R:R:T82	4.42	No	No	0	8	6
21	R:R:L65	R:R:T61	4.42	No	No	0	5	4
22	R:R:F367	R:R:T62	7.78	Yes	Yes	2	8	8
23	R:R:I370	R:R:T62	7.6	No	Yes	2	6	8
24	R:R:F363	R:R:I63	5.02	Yes	No	0	9	8
25	R:R:L69	R:R:T66	10.32	Yes	Yes	2	8	7
26	R:R:A366	R:R:T66	5.03	No	Yes	2	7	7
27	R:R:K369	R:R:T66	7.51	No	Yes	0	5	7
28	R:R:H70	R:R:R67	5.64	No	No	0	8	6
29	R:R:L69	R:R:N74	5.49	Yes	Yes	2	8	9
30	R:R:F363	R:R:L69	6.09	Yes	Yes	2	9	8
31	R:R:A366	R:R:L69	3.15	No	Yes	2	7	8
32	R:R:H70	R:R:Y75	6.53	No	No	0	8	4
33	R:R:P72	R:R:T71	3.5	No	No	0	6	7
34	R:R:N74	R:R:T71	8.77	Yes	No	0	9	7
35	R:R:A73	R:R:R150	4.15	No	Yes	0	8	7
36	R:R:E362	R:R:N74	3.94	No	Yes	0	7	9
37	R:R:F363	R:R:N74	7.25	Yes	Yes	2	9	9
38	R:R:L76	R:R:V131	4.47	No	No	0	8	7
39	R:R:D135	R:R:L76	4.07	No	No	0	9	8
40	R:R:A155	R:R:L76	3.15	No	No	0	7	8
41	R:R:I132	R:R:I77	4.42	Yes	No	2	9	8
42	R:R:I77	R:R:Y356	4.84	No	Yes	2	8	9
43	R:R:F363	R:R:I77	6.28	Yes	No	2	9	8
44	R:R:H128	R:R:S79	9.76	Yes	No	3	8	9
45	R:R:I159	R:R:S79	10.84	No	No	3	8	9
46	R:R:D84	R:R:L80	4.07	Yes	Yes	2	9	9
47	R:R:L129	R:R:L80	5.54	No	Yes	2	8	9
48	R:R:I132	R:R:L80	4.28	Yes	Yes	2	9	9
49	R:R:L80	R:R:N352	4.12	Yes	Yes	2	9	9
50	R:R:L80	R:R:Y356	3.52	Yes	Yes	2	9	9
51	R:R:A124	R:R:T83	3.36	No	No	3	8	9
52	R:R:H128	R:R:T83	6.85	Yes	No	3	8	9
53	R:R:T83	R:R:W163	4.85	No	No	3	9	9
54	R:R:D84	R:R:S349	7.36	Yes	No	0	9	9
55	R:R:D84	R:R:N352	4.04	Yes	Yes	2	9	9
56	R:R:S349	R:R:V87	4.85	No	No	0	9	7
57	R:R:M92	R:R:S88	4.6	Yes	No	1	8	7
58	R:R:V91	R:R:W114	4.9	Yes	Yes	1	8	6
59	R:R:S117	R:R:V91	3.23	No	Yes	0	5	8
60	R:R:D118	R:R:V91	5.84	No	Yes	1	8	8
61	R:R:V91	R:R:Y346	5.05	Yes	Yes	1	8	8
62	R:R:M92	R:R:W343	4.65	Yes	Yes	1	8	7
63	R:R:I94	R:R:W104	3.52	No	Yes	1	6	8
64	R:R:I94	R:R:W114	16.44	No	Yes	1	6	6
65	R:R:S95	R:R:W343	6.18	No	Yes	1	7	7
66	R:R:S95	R:R:Y346	6.36	No	Yes	1	7	8
67	R:R:I96	R:R:W343	5.87	No	Yes	1	6	7
68	R:R:W104	R:R:Y98	10.61	Yes	No	0	8	5
69	R:R:D187	R:R:Y98	3.45	No	No	0	3	5
70	R:R:T99	R:R:W343	3.64	No	Yes	0	6	7
71	R:R:I100	R:R:T101	4.56	Yes	No	0	5	4
72	R:R:D339	R:R:H102	5.04	No	No	0	6	4
73	R:R:F106	R:R:W104	6.01	No	Yes	1	6	8
74	R:R:L110	R:R:W104	3.42	No	Yes	1	5	8
75	R:R:C111	R:R:W104	6.53	Yes	Yes	1	9	8
76	R:R:W104	R:R:W114	11.25	Yes	Yes	1	8	6
77	R:R:C188	R:R:W104	15.67	Yes	Yes	1	9	8
78	R:R:F106	R:R:L110	10.96	No	No	1	6	5
79	R:R:C111	R:R:Q108	6.1	Yes	No	0	9	4
80	R:R:D112	R:R:Q108	13.05	No	No	0	6	4
81	R:R:C111	R:R:L115	3.17	Yes	No	1	9	6
82	R:R:C111	R:R:C188	7.28	Yes	Yes	1	9	9
83	R:R:L115	R:R:W114	4.56	No	Yes	1	6	6
84	R:R:C188	R:R:W114	3.92	Yes	Yes	1	9	6
85	R:R:C188	R:R:L115	4.76	Yes	No	1	9	6
86	R:R:S116	R:R:S170	4.89	No	No	0	6	8
87	R:R:D118	R:R:Y346	9.2	No	Yes	1	8	8
88	L:L:?1	R:R:D118	11.54	Yes	No	1	0	8
89	R:R:I119	R:R:S170	6.19	No	No	0	7	8
90	L:L:?1	R:R:I119	7.28	Yes	No	0	0	7
91	R:R:S170	R:R:T120	6.4	No	No	0	8	6
92	R:R:C122	R:R:W314	6.53	No	Yes	1	7	8
93	L:L:?1	R:R:C122	13.5	Yes	No	1	0	7
94	R:R:S166	R:R:T123	6.4	No	No	0	8	7
95	R:R:I169	R:R:T123	9.12	No	No	0	7	7
96	R:R:A124	R:R:W163	7.78	No	No	3	8	9
97	R:R:A124	R:R:S166	3.42	No	No	0	8	8
98	R:R:I126	R:R:P209	3.39	Yes	No	0	8	9
99	R:R:F310	R:R:I126	5.02	Yes	Yes	1	9	8
100	R:R:I126	R:R:W314	5.87	Yes	Yes	1	8	8
101	R:R:C130	R:R:W127	3.92	No	No	0	7	6
102	R:R:V162	R:R:W127	4.9	No	No	0	7	6
103	R:R:I165	R:R:W127	15.27	No	No	0	5	6
104	R:R:H128	R:R:I159	6.63	Yes	No	3	8	8
105	R:R:H128	R:R:V162	6.92	Yes	No	0	8	7
106	R:R:H128	R:R:W163	4.23	Yes	No	3	8	9
107	R:R:L129	R:R:N352	10.98	No	Yes	2	8	9
108	R:R:L129	R:R:Y356	7.03	No	Yes	2	8	9
109	R:R:C130	R:R:L212	4.76	No	No	0	7	7
110	R:R:M158	R:R:V131	7.61	No	No	0	6	7
111	R:R:V131	R:R:V162	3.21	No	No	0	7	7
112	R:R:I132	R:R:R136	6.26	Yes	No	2	9	9
113	R:R:I132	R:R:Y356	7.25	Yes	Yes	2	9	9
114	R:R:A133	R:R:L216	3.15	No	No	0	9	6
115	R:R:A133	R:R:Y217	4	No	Yes	0	9	9
116	R:R:L134	R:R:W138	9.11	No	Yes	0	6	5
117	R:R:L134	R:R:L216	9.69	No	No	0	6	6
118	R:R:D135	R:R:Y146	11.49	No	Yes	4	9	8
119	R:R:D135	R:R:R150	13.1	No	Yes	4	9	7
120	R:R:R136	R:R:Y217	6.17	No	Yes	0	9	9
121	R:R:R136	R:R:Y356	9.26	No	Yes	2	9	9
122	R:R:W138	R:R:Y137	4.82	Yes	Yes	0	5	8
123	R:R:T141	R:R:Y137	16.23	No	Yes	0	7	8
124	R:R:L216	R:R:Y137	4.69	No	Yes	0	6	8
125	R:R:R219	R:R:Y137	13.38	No	Yes	0	5	8
126	R:R:I220	R:R:Y137	3.63	No	Yes	0	9	8
127	R:R:D142	R:R:W138	5.58	No	Yes	4	6	5
128	R:R:W138	R:R:Y146	17.36	Yes	Yes	4	5	8
129	R:R:R149	R:R:W138	6	No	Yes	4	5	5
130	R:R:A139	R:R:R150	4.15	No	Yes	0	8	7
131	R:R:I140	R:R:I220	5.89	No	No	0	8	9
132	R:R:D142	R:R:T141	4.34	No	No	0	6	7
133	R:R:D142	R:R:R149	4.76	No	No	4	6	5
134	R:R:R149	R:R:Y146	4.12	No	Yes	4	5	8
135	R:R:R150	R:R:Y146	17.49	Yes	Yes	4	7	8
136	R:R:H154	R:R:Y146	3.27	No	Yes	0	7	8
137	R:R:H154	R:R:M158	11.82	No	No	0	7	6
138	R:R:I167	R:R:I171	5.89	No	No	0	4	4
139	R:R:I169	R:R:Y200	6.04	No	No	0	7	5
140	R:R:I171	R:R:P172	3.39	No	Yes	0	4	7
141	R:R:F175	R:R:I171	3.77	No	No	0	5	4
142	R:R:P172	R:R:P173	5.84	Yes	No	6	7	7
143	R:R:P172	R:R:Y197	4.17	Yes	No	6	7	8
144	R:R:P173	R:R:Y197	11.13	No	No	6	7	8
145	R:R:Q194	R:R:W176	16.43	No	No	0	6	7
146	L:L:?1	R:R:V190	5.07	Yes	No	0	0	6
147	R:R:N191	R:R:S193	8.94	No	No	7	4	4
148	R:R:N191	R:R:Q194	5.28	No	No	7	4	6
149	R:R:P325	R:R:T192	6.99	No	No	0	6	5
150	R:R:Q194	R:R:S193	4.33	No	No	7	6	4
151	R:R:I195	R:R:T198	6.08	No	No	0	4	6
152	R:R:S201	R:R:Y197	10.17	No	No	0	7	8
153	R:R:P325	R:R:T198	8.74	No	No	0	6	6
154	L:L:?1	R:R:S201	7.66	Yes	No	0	0	7
155	R:R:T202	R:R:Y207	3.75	No	No	1	6	6
156	R:R:L322	R:R:T202	10.32	No	No	1	5	6
157	R:R:G204	R:R:I208	3.53	No	No	0	4	6
158	L:L:?1	R:R:A205	4.02	Yes	No	0	0	7
159	R:R:F206	R:R:S210	10.57	Yes	No	1	8	6
160	R:R:F206	R:R:F310	10.72	Yes	Yes	1	8	9
161	R:R:F206	R:R:L315	9.74	Yes	No	0	8	6
162	R:R:F206	R:R:F318	20.36	Yes	Yes	1	8	7
163	R:R:L322	R:R:Y207	5.86	No	No	1	5	6
164	R:R:I208	R:R:P209	3.39	No	No	0	6	9
165	R:R:F310	R:R:S210	3.96	Yes	No	1	9	6
166	R:R:L213	R:R:Y217	4.69	No	Yes	0	8	9
167	R:R:F310	R:R:L213	4.87	Yes	No	0	9	8
168	R:R:I215	R:R:R219	7.52	No	No	0	4	5
169	R:R:I306	R:R:Y217	13.3	No	Yes	0	9	9
170	R:R:L307	R:R:Y217	5.86	No	Yes	0	8	9
171	R:R:R225	R:R:Y221	11.32	No	Yes	0	6	6
172	R:R:T300	R:R:Y221	11.24	No	Yes	0	8	6
173	R:R:L303	R:R:Y221	3.52	No	Yes	0	8	6
174	R:R:L229	R:R:R225	3.64	No	No	8	4	6
175	R:R:E296	R:R:R225	10.47	No	No	8	8	6
176	R:R:P231	R:R:R227	8.65	No	No	9	1	7
177	R:R:R227	R:R:Y235	5.14	No	No	9	7	3
178	R:R:E296	R:R:I228	9.56	No	No	0	8	5
179	R:R:E296	R:R:L229	10.6	No	No	8	8	4
180	R:R:P231	R:R:Y235	4.17	No	No	9	1	3
181	R:R:L234	R:R:P232	8.21	No	No	0	1	2
182	R:R:R238	R:R:Y235	8.23	No	No	0	2	3
183	R:R:R238	R:R:R288	5.33	No	No	0	2	5
184	R:R:R288	R:R:S284	5.27	No	No	0	5	4
185	R:R:I291	R:R:R295	7.52	No	No	0	5	7
186	R:R:I302	R:R:K298	7.27	No	No	0	8	8
187	R:R:I305	R:R:K301	4.36	No	No	0	6	8
188	R:R:F359	R:R:I302	18.84	Yes	No	0	7	8
189	R:R:I305	R:R:I355	4.42	No	Yes	5	6	8
190	R:R:F359	R:R:I305	3.77	Yes	No	5	7	6
191	R:R:I306	R:R:I355	4.42	No	Yes	0	9	8
192	R:R:F310	R:R:I311	3.77	Yes	No	0	9	6
193	R:R:F310	R:R:W314	7.02	Yes	Yes	1	9	8
194	R:R:C313	R:R:N348	4.72	No	No	0	8	9
195	R:R:F317	R:R:W314	11.02	Yes	Yes	1	8	8
196	R:R:F318	R:R:W314	10.02	Yes	Yes	1	7	8
197	R:R:G345	R:R:W314	8.44	No	Yes	0	7	8
198	R:R:N348	R:R:W314	12.43	No	Yes	0	9	8
199	L:L:?1	R:R:W314	3.87	Yes	Yes	1	0	8
200	R:R:L315	R:R:P316	3.28	No	No	0	6	9
201	R:R:F341	R:R:P316	8.67	Yes	No	0	5	9
202	R:R:F317	R:R:F318	3.22	Yes	Yes	1	8	7
203	R:R:F317	R:R:F338	3.22	Yes	No	0	8	5
204	L:L:?1	R:R:F317	11.39	Yes	Yes	1	0	8
205	L:L:?1	R:R:F318	9.32	Yes	Yes	1	0	7
206	R:R:F341	R:R:V320	5.24	Yes	No	0	5	4
207	L:L:?1	R:R:S321	5.11	Yes	No	0	0	7
208	R:R:C327	R:R:V323	5.12	No	No	0	6	6
209	R:R:I333	R:R:L324	4.28	No	No	0	4	4
210	R:R:C327	R:R:C331	7.28	No	No	0	6	7
211	R:R:H334	R:R:W332	6.35	Yes	No	0	5	2
212	R:R:I333	R:R:L337	5.71	No	No	0	4	4
213	R:R:H334	R:R:P335	7.63	Yes	No	0	5	1
214	R:R:F341	R:R:L337	9.74	Yes	No	0	5	4
215	R:R:F340	R:R:F341	4.29	No	Yes	0	5	5
216	R:R:T342	R:R:Y346	3.75	No	Yes	0	6	8
217	R:R:W343	R:R:Y346	6.75	Yes	Yes	1	7	8
218	L:L:?1	R:R:Y346	4.98	Yes	Yes	1	0	8
219	R:R:I351	R:R:L347	7.14	No	No	0	7	4
220	R:R:N348	R:R:N352	13.62	No	Yes	0	9	9
221	R:R:F359	R:R:I355	5.02	Yes	Yes	5	7	8
222	R:R:F363	R:R:T357	7.78	Yes	No	2	9	7
223	R:R:F367	R:R:T357	7.78	Yes	No	2	8	7
224	R:R:F359	R:R:V358	9.18	Yes	No	0	7	5
225	R:R:E362	R:R:N360	14.46	No	No	0	7	9
226	R:R:F363	R:R:N360	10.87	Yes	No	0	9	9
227	R:R:E361	R:R:R364	5.82	No	No	0	5	8
228	R:R:F363	R:R:F367	3.22	Yes	Yes	2	9	8
229	R:R:T101	R:R:T103	3.14	No	No	0	4	3
230	R:R:I126	R:R:S125	3.1	Yes	No	0	8	9
231	R:R:I228	R:R:S292	3.1	No	No	0	5	6
232	R:R:F206	R:R:Y207	3.09	Yes	No	1	8	6
233	R:R:I161	R:R:T157	3.04	No	No	0	3	3
234	R:R:L50	R:R:S46	3	No	No	0	4	2
235	R:R:L90	R:R:S117	3	No	No	0	5	5
236	R:R:L45	R:R:V44	2.98	Yes	No	0	7	4
237	R:R:I161	R:R:I165	2.94	No	No	0	3	5
238	R:R:I195	R:R:I199	2.94	No	No	0	4	5
239	R:R:I195	R:R:I326	2.94	No	No	0	4	4
240	R:R:I351	R:R:I355	2.94	No	Yes	5	7	8
241	R:R:A336	R:R:H334	2.93	No	Yes	0	1	5
242	R:R:D339	R:R:T99	2.89	No	No	0	6	6
243	R:R:P232	R:R:R227	2.88	No	No	0	2	7
244	R:R:I100	R:R:L41	2.85	Yes	No	0	5	5
245	R:R:I89	R:R:L90	2.85	No	No	0	5	5
246	R:R:I214	R:R:L307	2.85	No	No	0	5	8
247	R:R:G107	R:R:W104	2.81	No	Yes	0	7	8
248	R:R:L34	R:R:L37	2.77	No	No	0	5	2
249	R:R:L60	R:R:L85	2.77	No	No	0	8	7
250	R:R:L86	R:R:L90	2.77	No	No	0	7	5
251	R:R:P172	R:R:W176	2.7	Yes	No	0	7	7
252	R:R:A152	R:R:Y75	2.67	No	No	0	3	4
253	R:R:E361	R:R:N360	2.63	No	No	0	5	9
254	R:R:F239	R:R:K237	2.48	No	No	0	1	3
255	R:R:L189	R:R:Y98	2.34	No	No	0	4	5
256	R:R:L303	R:R:Y217	2.34	No	Yes	0	8	9
257	R:R:C203	R:R:G204	1.96	No	No	0	4	4
258	R:R:A81	R:R:G78	1.95	No	No	0	9	7
259	R:R:A156	R:R:G153	1.95	No	No	0	3	5
260	R:R:G153	R:R:T151	1.82	No	No	0	5	8
261	R:R:G78	R:R:I63	1.76	No	No	0	7	8
262	R:R:G308	R:R:I311	1.76	No	No	0	6	6
263	R:R:G308	R:R:I312	1.76	No	No	0	6	6
264	R:R:C121	R:R:S117	1.72	No	No	0	7	5
265	R:R:I94	R:R:P93	1.69	No	No	0	6	8
266	R:R:C203	R:R:I199	1.64	No	No	0	4	5
267	R:R:L344	R:R:P316	1.64	No	No	0	7	9
268	R:R:L324	R:R:P325	1.64	No	No	0	4	6
269	R:R:N230	R:R:P231	1.63	No	No	0	3	1
270	R:R:A36	R:R:I39	1.62	No	No	0	3	5
271	R:R:A42	R:R:I100	1.62	No	Yes	0	5	5
272	R:R:A223	R:R:I140	1.62	No	No	0	5	8
273	R:R:A224	R:R:I228	1.62	No	No	0	8	5
274	R:R:A309	R:R:I351	1.62	No	No	5	5	7
275	R:R:A309	R:R:I355	1.62	No	Yes	5	5	8
276	R:R:V319	R:R:V320	1.6	No	No	0	6	4
277	R:R:A51	R:R:L350	1.58	No	No	0	4	6
278	R:R:A57	R:R:L85	1.58	No	No	0	4	7
279	R:R:T61	R:R:T62	1.57	No	Yes	0	4	8
280	R:R:I48	R:R:V44	1.54	No	No	0	7	4
281	R:R:K68	R:R:T66	1.5	No	Yes	0	5	7
282	R:R:L324	R:R:V323	1.49	No	No	0	4	6
283	R:R:L50	R:R:T49	1.47	No	No	0	4	7
284	R:R:I100	R:R:K38	1.45	Yes	No	0	5	4
285	R:R:G218	R:R:Y221	1.45	No	Yes	0	3	6
286	R:R:I354	R:R:L350	1.43	No	No	0	7	6
287	R:R:K38	R:R:L37	1.41	No	No	0	4	2
288	R:R:A294	R:R:R297	1.38	No	No	0	4	6
289	R:R:H154	R:R:T151	1.37	No	No	0	7	8
290	R:R:L229	R:R:N230	1.37	No	No	0	4	3
291	R:R:D112	R:R:L174	1.36	No	No	0	6	6
292	R:R:C168	R:R:Y200	1.34	No	No	0	4	5
293	R:R:A155	R:R:Y75	1.33	No	No	0	7	4
294	R:R:H334	R:R:L337	1.29	Yes	No	0	5	4
295	R:R:E361	R:R:Q365	1.27	No	No	0	5	5
296	R:R:N191	R:R:R177	1.21	No	No	0	4	4
297	R:R:E287	R:R:R288	1.16	No	No	0	5	5
298	R:R:R219	R:R:R222	1.07	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L45	7.815	4	1	7
2	R:R:T52	6.36	4	1	8
3	R:R:N56	6.7875	4	0	9
4	R:R:F58	6.91	4	2	8
5	R:R:T62	6.1825	4	2	8
6	R:R:T66	6.09	4	2	7
7	R:R:L69	6.2625	4	2	8
8	R:R:N74	6.3625	4	2	9
9	R:R:L80	4.306	5	2	9
10	R:R:D84	6.8975	4	2	9
11	R:R:V91	4.755	4	1	8
12	R:R:M92	6.4525	4	1	8
13	R:R:I100	2.62	4	0	5
14	R:R:W104	7.4775	8	1	8
15	R:R:C111	5.77	4	1	9
16	R:R:W114	8.214	5	1	6
17	R:R:I126	4.345	4	1	8
18	R:R:H128	6.878	5	3	8
19	R:R:I132	5.5525	4	2	9
20	R:R:Y137	8.55	5	0	8
21	R:R:W138	8.574	5	4	5
22	R:R:Y146	10.746	5	4	8
23	R:R:R150	9.7225	4	4	7
24	R:R:P172	4.025	4	6	7
25	R:R:C188	7.9075	4	1	9
26	R:R:F206	10.896	5	1	8
27	R:R:Y217	6.06	6	0	9
28	R:R:Y221	6.8825	4	0	6
29	R:R:F310	5.89333	6	1	9
30	R:R:W314	8.15	8	1	8
31	R:R:F317	7.2125	4	1	8
32	R:R:F318	10.73	4	1	7
33	R:R:H334	4.55	4	0	5
34	R:R:F341	6.985	4	0	5
35	R:R:W343	7.36167	6	1	7
36	R:R:Y346	6.015	6	1	8
37	R:R:N352	8.19	4	2	9
38	R:R:I355	3.684	5	5	8
39	R:R:Y356	6.38	5	2	9
40	R:R:F359	9.2025	4	5	7
41	R:R:F363	6.64429	7	2	9
42	R:R:F367	7.1075	4	2	8
43	L:L:?1	7.61273	11	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N56	R:R:T52	14.7366	4.39	Yes	Yes	0	9	8
2	R:R:D84	R:R:N56	17.5264	12.12	Yes	Yes	0	9	9
3	R:R:D135	R:R:L76	43.119	4.07	No	No	0	9	8
4	R:R:D135	R:R:Y146	44.2258	11.49	No	Yes	4	9	8
5	R:R:W138	R:R:Y146	90.3942	17.36	Yes	Yes	4	5	8
6	R:R:L134	R:R:W138	46.4872	9.11	No	Yes	0	6	5
7	R:R:L134	R:R:L216	46.9996	9.69	No	No	0	6	6
8	R:R:A133	R:R:L216	99.6721	3.15	No	No	0	9	6
9	R:R:A133	R:R:Y217	100	4	No	Yes	0	9	9
10	R:R:L213	R:R:Y217	69.0784	4.69	No	Yes	0	8	9
11	R:R:F310	R:R:L213	68.8415	4.87	Yes	No	0	9	8
12	R:R:F310	R:R:W314	49.8668	7.02	Yes	Yes	1	9	8
13	L:L:?1	R:R:W314	62.9045	3.87	Yes	Yes	1	0	8
14	L:L:?1	R:R:Y346	36.5444	4.98	Yes	Yes	1	0	8
15	R:R:W343	R:R:Y346	17.515	6.75	Yes	Yes	1	7	8
16	R:R:W138	R:R:Y137	47.5803	4.82	Yes	Yes	0	5	8
17	R:R:L216	R:R:Y137	52.3741	4.69	No	Yes	0	6	8
18	R:R:L76	R:R:V131	35.1393	4.47	No	No	0	8	7
19	R:R:H154	R:R:Y146	41.4133	3.27	No	Yes	0	7	8
20	R:R:H154	R:R:M158	36.18	11.82	No	No	0	7	6
21	R:R:M158	R:R:V131	34.8546	7.61	No	No	0	6	7
22	R:R:I132	R:R:L80	15.2149	4.28	Yes	Yes	2	9	9
23	R:R:D84	R:R:L80	17.8179	4.07	Yes	Yes	2	9	9
24	R:R:I132	R:R:I77	20.3275	4.42	Yes	No	2	9	8
25	R:R:I77	R:R:Y356	25.6268	4.84	No	Yes	2	8	9
26	R:R:L80	R:R:Y356	15.1989	3.52	Yes	Yes	2	9	9
27	R:R:H128	R:R:V162	47.8103	6.92	Yes	No	0	8	7
28	R:R:V131	R:R:V162	67.1153	3.21	No	No	0	7	7
29	R:R:N348	R:R:N352	20.3799	13.62	No	Yes	0	9	9
30	R:R:N348	R:R:W314	21.4866	12.43	No	Yes	0	9	8
31	R:R:A124	R:R:T83	16.9274	3.36	No	No	3	8	9
32	R:R:H128	R:R:T83	19.7331	6.85	Yes	No	3	8	9
33	R:R:A124	R:R:W163	16.9274	7.78	No	No	3	8	9
34	R:R:H128	R:R:W163	19.7331	4.23	Yes	No	3	8	9
35	R:R:V91	R:R:Y346	26.3009	5.05	Yes	Yes	1	8	8
36	R:R:V91	R:R:W114	38.9128	4.9	Yes	Yes	1	8	6
37	R:R:W104	R:R:W114	17.8748	11.25	Yes	Yes	1	8	6
38	R:R:C111	R:R:Q108	14.6934	6.1	Yes	No	0	9	4
39	R:R:A124	R:R:S166	28.2253	3.42	No	No	0	8	8
40	R:R:S166	R:R:T123	22.5889	6.4	No	No	0	8	7
41	R:R:I169	R:R:T123	16.9479	9.12	No	No	0	7	7
42	R:R:V162	R:R:W127	17.0231	4.9	No	No	0	7	6
43	R:R:I132	R:R:R136	24.5519	6.26	Yes	No	2	9	9
44	R:R:R136	R:R:Y356	25.3877	9.26	No	Yes	2	9	9
45	R:R:R136	R:R:Y217	50.3746	6.17	No	Yes	0	9	9
46	R:R:S201	R:R:Y197	11.0952	10.17	No	No	0	7	8
47	L:L:?1	R:R:S201	12.0767	7.66	Yes	No	0	0	7
48	R:R:I169	R:R:Y200	11.3024	6.04	No	No	0	7	5
49	R:R:F206	R:R:L315	17.6562	9.74	Yes	No	0	8	6
50	R:R:L315	R:R:P316	16.7657	3.28	No	No	0	6	9
51	R:R:F341	R:R:P316	14.9803	8.67	Yes	No	0	5	9
52	R:R:F341	R:R:L337	11.373	9.74	Yes	No	0	5	4
53	R:R:I306	R:R:Y217	10.8196	13.3	No	Yes	0	9	9
54	R:R:L303	R:R:Y217	19.1342	2.34	No	Yes	0	8	9
55	R:R:L303	R:R:Y221	18.2141	3.52	No	Yes	0	8	6
56	R:R:R225	R:R:Y221	15.4267	11.32	No	Yes	0	6	6
57	R:R:L229	R:R:R225	10.6329	3.64	No	No	8	4	6
58	R:R:F206	R:R:F310	14.6341	10.72	Yes	Yes	1	8	9
59	R:R:F363	R:R:I77	44.1233	6.28	Yes	No	2	9	8
60	R:R:F363	R:R:F367	10.8925	3.22	Yes	Yes	2	9	8
61	L:L:?1	R:R:D118	22.5479	11.54	Yes	No	1	0	8
62	R:R:D118	R:R:V91	21.8601	5.84	No	Yes	1	8	8
63	R:R:L80	R:R:N352	12.1405	4.12	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D118	R:R:V91	5.84	1	No	Yes	8	8	1	2
R:R:V91	R:R:Y346	5.05	1	Yes	Yes	8	8	2	1
R:R:S95	R:R:W343	6.18	1	No	Yes	7	7	2	2
R:R:S95	R:R:Y346	6.36	1	No	Yes	7	8	2	1
R:R:D118	R:R:Y346	9.2	1	No	Yes	8	8	1	1
L:L:?1	R:R:D118	11.54	1	Yes	No	0	8	0	1
R:R:I119	R:R:S170	6.19	0	No	No	7	8	1	2
L:L:?1	R:R:I119	7.28	1	Yes	No	0	7	0	1
R:R:C122	R:R:W314	6.53	1	No	Yes	7	8	1	1
L:L:?1	R:R:C122	13.5	1	Yes	No	0	7	0	1
R:R:F310	R:R:I126	5.02	1	Yes	Yes	9	8	2	2
R:R:I126	R:R:W314	5.87	1	Yes	Yes	8	8	2	1
L:L:?1	R:R:V190	5.07	1	Yes	No	0	6	0	1
R:R:S201	R:R:Y197	10.17	0	No	No	7	8	1	2
L:L:?1	R:R:S201	7.66	1	Yes	No	0	7	0	1
L:L:?1	R:R:A205	4.02	1	Yes	No	0	7	0	1
R:R:F206	R:R:F310	10.72	1	Yes	Yes	8	9	2	2
R:R:F206	R:R:F318	20.36	1	Yes	Yes	8	7	2	1
R:R:F310	R:R:W314	7.02	1	Yes	Yes	9	8	2	1
R:R:F317	R:R:W314	11.02	1	Yes	Yes	8	8	1	1
R:R:F318	R:R:W314	10.02	1	Yes	Yes	7	8	1	1
R:R:G345	R:R:W314	8.44	0	No	Yes	7	8	2	1
R:R:N348	R:R:W314	12.43	0	No	Yes	9	8	2	1
L:L:?1	R:R:W314	3.87	1	Yes	Yes	0	8	0	1
R:R:F317	R:R:F318	3.22	1	Yes	Yes	8	7	1	1
R:R:F317	R:R:F338	3.22	1	Yes	No	8	5	1	2
L:L:?1	R:R:F317	11.39	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F318	9.32	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:S321	5.11	1	Yes	No	0	7	0	1
R:R:T342	R:R:Y346	3.75	0	No	Yes	6	8	2	1
R:R:W343	R:R:Y346	6.75	1	Yes	Yes	7	8	2	1
L:L:?1	R:R:Y346	4.98	1	Yes	Yes	0	8	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7E32_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	253
Number of Links	298
Number of Hubs	43
Number of Links mediated by Hubs	164
Number of Communities	9
Number of Nodes involved in Communities	77
Number of Links involved in Communities	110

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	80471
Length Of Smallest Path	3
Average Path Length	15.1673
Length of Longest Path	30
Minimum Path Strength	1.43
Average Path Strength	6.44201
Maximum Path Strength	17.425
Minimum Path Correlation	0.7
Average Path Correlation	0.946456
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	52.9414
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.2098
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • electron transport chain • metabolic process • generation of precursor metabolites and energy • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • intestine smooth muscle contraction • gastro-intestinal system smooth muscle contraction • smooth muscle contraction • phasic smooth muscle contraction • muscle contraction • muscle system process • trans-synaptic signaling • anterograde trans-synaptic signaling • chemical synaptic transmission • regulation of tube diameter • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • regulation of biological quality • vasoconstriction • blood circulation • regulation of anatomical structure size • regulation of behavior • behavior • regulation of multicellular organismal process • regulation of locomotion • locomotion • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • periplasmic space • somatodendritic compartment • dendrite • dendritic tree
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	SRO
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	SRO
Name	Serotonin
Synonyms	thrombotonin
Identifier
Formula	C10 H12 N2 O
Molecular Weight	176.215
SMILES
PubChem	5202
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	0
Total Bonds	26
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P28221
Sequence	>7E32_nogp_Chain_R L Q A L K I S L A V V L S V I T L A T V L S N A F V L T T I L L T R K L H T P A N Y L I G S L A T T D L L V S I L V M P I S I A Y T I T H T W N F G Q I L C D I W L S S D I T C C T A S I W H L C V I A L D R Y W A I T D A L E Y S K R R T A G H A A T M I A I V W A I S I C I S I P P L F W R D C L V N T S Q I S Y T I Y S T C G A F Y I P S V L L I I L Y G R I Y R A A R N R I L N P P S L Y G K R F S A L E R K R I S A A R E R K A T K I L G I I L G A F I I C W L P F F V V S L V L P I C R D S C W I H P A L F D F F T W L G Y L N S L I N P I I Y T V F N E E F R Q A F Q K I V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7E32	A	Amine	5-Hydroxytryptamine	5-HT_1D	Homo sapiens	Serotonin	-	Gi1/β1/γ2	2.9	2021-04-21	doi.org/10.1038/s41586-021-03376-8
	7E32 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1D	Homo sapiens	Serotonin	-		2.9	2021-04-21	doi.org/10.1038/s41586-021-03376-8

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