Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:N50 7.945119
2A:A:I207 4.888559
3A:A:F212 7.2325409
4A:A:F219 5.744228
5A:A:F222 9.906557
6A:A:R232 8.8175468
7A:A:K233 6.27571769
8A:A:W234 6.56167609
9A:A:F238 10.0825409
10A:A:D249 9.9254118
11A:A:S251 5.58754119
12A:A:D252 7.97754118
13A:A:R265 6.23754119
14A:A:F273 7.0385269
15A:A:I276 5.275408
16A:A:W277 8.7645266
17A:A:W281 9.79505
18A:A:F290 6.286676249
19A:A:N292 4.3425409
20A:A:F312 6.05754278
21A:A:P321 6.6925405
22A:A:Y339 8.36593
23A:A:R342 6.222594
24A:A:E344 8.5654275
25A:A:F345 8.665408
26A:A:F363 7.042595
27A:A:N371 6.5345249
28A:A:R374 7.5575404
29A:A:F376 9.49408
30A:A:I383 4.86754218
31A:A:R385 7.26754285
32A:A:Y391 6.744144
33R:R:T227 5.1475409
34R:R:Y228 6.052508
35R:R:F229 4.5275409
36R:R:M233 3.9408
37R:R:Q234 7.722507
38R:R:P241 4.6405
39R:R:L245 4.7725403
40R:R:K275 6.2975405
41R:R:L280 9.165407
42R:R:H284 10.30754158
43R:R:S290 4.274107
44R:R:H322 7.1965169
45R:R:W331 8.726676109
46R:R:M332 5.7554129
47R:R:N338 5.9675407
48R:R:L342 5.5407
49R:R:Y347 9.204507
50R:R:R353 3.5454294
51R:R:Y354 9.3225306
52R:R:W363 7.391676109
53R:R:P366 4.06754109
54R:R:Y381 4.887169
55R:R:G382 2.5825405
56R:R:D390 5.9404
57R:R:M401 4.4925402
58R:R:V406 5.135168
59R:R:L415 5.054507
60R:R:W433 3.8725404
61R:R:R442 4.8754285
62R:R:L462 4.04254148
63R:R:W470 7.9545129
64R:R:L494 2.7875407
65R:R:Y495 7.1625129
66R:R:F500 4.272508
67R:R:W502 5.6125157
68R:R:F503 6.5425406
69R:R:R507 8.925407
70G:G:E22 6.5975419
71G:G:R27 6.0625418
72G:G:D48 9.565449
73G:G:L51 5.455446
74G:G:V54 4.3854326
75G:G:N59 3.1625409
76G:G:F61 5.992508
77B:B:V40 4.398543
78B:B:L51 8.52489
79B:B:H54 11.1775409
80B:B:K57 9.6825459
81B:B:Y59 13.4375458
82B:B:W63 6.956137
83B:B:I81 5.3075427
84B:B:W82 12.826589
85B:B:N88 5.5525407
86B:B:K89 8.416589
87B:B:H91 6.245425
88B:B:L95 6.042528
89B:B:W99 10.078559
90B:B:C103 3.825408
91B:B:Y105 4.90429726
92B:B:N110 6.505434
93B:B:Y111 6.126534
94B:B:C114 5.715428
95B:B:S122 4.3875428
96B:B:I123 3.89436
97B:B:Y124 5.54857726
98B:B:H142 7.77639
99B:B:Y145 6.73429768
100B:B:T159 6.0875439
101B:B:D163 8.165439
102B:B:C166 4.5854188
103B:B:L168 3.92406
104B:B:W169 8.39429738
105B:B:F180 7.268336187
106B:B:H183 6.076509
107B:B:D186 6.4725469
108B:B:L192 4.6975405
109B:B:F199 7.9645189
110B:B:V200 8.61416
111B:B:C204 6.105467
112B:B:L210 4.885405
113B:B:W211 8.9445188
114B:B:D212 5.09254199
115B:B:Q220 6.0675417
116B:B:F222 7.5425418
117B:B:H225 8.31833619
118B:B:D228 7.328569
119B:B:F234 6.8925405
120B:B:F235 7.5725176
121B:B:P236 6.034177
122B:B:F241 6.41333616
123B:B:T243 5.5175418
124B:B:D246 7.01469
125B:B:R251 8.74833618
126B:B:F253 5.14286716
127B:B:D258 11.278517
128B:B:Y264 7.32505
129B:B:F278 5.7956177
130B:B:R283 7.842549
131B:B:Y289 7.96714777
132B:B:N295 8.3325476
133B:B:L300 5.9225406
134B:B:R304 6.785675
135B:B:H311 8.8425409
136B:B:R314 12.9325458
137B:B:W332 11.832559
138B:B:D333 6.865409
139B:B:L336 6.355487
140B:B:K337 9.07446
141B:B:W339 7.88167649
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:I338 B:B:L51 11.20634.28NoYes059
2B:B:I338 B:B:W63 14.27384.7NoYes057
3B:B:M61 B:B:W63 19.81634.65NoYes1367
4B:B:C317 B:B:M61 20.189.73NoNo076
5B:B:C317 B:B:S316 20.53313.44NoNo079
6B:B:S316 B:B:W332 20.70934.94NoYes099
7B:B:K57 B:B:W332 32.094515.08YesYes599
8B:B:K57 B:B:Q75 32.00665.42YesNo599
9B:B:Q75 B:B:W99 63.8854.38NoYes599
10A:A:F238 B:B:W99 60.915113.03YesYes099
11A:A:F238 A:A:W234 60.19185.01YesYes099
12A:A:W234 B:B:Y145 95.06826.75YesYes098
13B:B:G162 B:B:Y145 55.918110.14NoYes098
14B:B:G162 B:B:S161 55.62243.71NoNo099
15B:B:H142 B:B:S161 52.513316.74YesNo399
16B:B:H142 B:B:W169 50.1938.46YesYes398
17B:B:I157 B:B:W169 48.16943.52NoYes378
18B:B:I123 B:B:I157 47.55392.94YesNo367
19B:B:I123 B:B:Y111 46.9663.63YesYes364
20B:B:A106 B:B:Y111 43.33792.67NoYes064
21B:B:A106 B:B:F151 42.12259.71NoNo069
22B:B:A113 B:B:F151 41.51374.16NoNo099
23B:B:A113 B:B:C149 41.2093.61NoNo098
24B:B:C149 B:B:T102 40.90418.45NoNo088
25B:B:C148 B:B:T102 40.5993.38NoNo068
26B:B:C148 B:B:R150 40.29388.36NoNo066
27B:B:H62 B:B:R150 13.017613.54NoNo066
28B:B:H62 B:B:Y105 12.69593.27NoYes066
29B:B:W332 B:B:Y59 32.094513.5YesYes598
30B:B:Q75 B:B:Y59 32.006623.67NoYes598
31B:B:R314 B:B:W332 38.700919.99YesYes589
32A:A:W281 B:B:R314 38.53526YesYes058
33A:A:N279 A:A:W281 38.33655.65NoYes085
34A:A:I235 A:A:N279 29.9674.25NoNo2598
35A:A:I235 A:A:W234 29.94723.52NoYes099
36B:B:N313 B:B:W332 1005.65NoYes079
37B:B:D333 B:B:N313 99.96464.04YesNo097
38B:B:D312 B:B:D333 87.68847.98NoYes059
39B:B:D312 R:R:Q276 87.611213.05NoNo055
40R:R:K275 R:R:Q276 87.535410.85YesNo055
41R:R:D278 R:R:K275 52.46994.15NoYes075
42A:A:Q390 R:R:D278 52.28875.22NoNo047
43A:A:Q390 R:R:L280 12.28717.99NoYes047
44R:R:L280 R:R:N338 11.28285.49YesYes077
45R:R:N338 R:R:Y354 22.96785.81YesYes076
46A:A:Q390 R:R:L342 40.38433.99NoYes047
47R:R:L342 R:R:N338 12.80595.49YesYes077
48A:A:H41 A:A:I383 32.8325.3NoYes2168
49A:A:H387 A:A:I383 33.44576.63NoYes088
50A:A:H387 R:R:L342 33.74229NoYes087
51A:A:H41 R:R:Y347 32.70115.44NoYes067
52A:A:K293 A:A:N292 13.13366.99NoYes099
53A:A:I56 A:A:N292 16.26824.25NoYes079
54A:A:I56 A:A:N371 16.794.25NoYes079
55A:A:F290 A:A:N371 12.576810.87YesYes2499
56A:A:D378 A:A:Y360 21.783816.09NoNo078
57A:A:D381 A:A:Y360 22.270510.34NoNo088
58A:A:D381 A:A:R385 22.43248.34NoYes085
59A:A:R385 R:R:L441 22.81786.07YesNo2854
60A:A:Q384 R:R:L441 24.360313.31NoNo064
61A:A:Q384 R:R:V346 26.26115.73NoNo068
62A:A:R380 R:R:V346 26.418314.38NoNo078
63A:A:R380 R:R:Y347 26.57537.2NoYes077
64A:A:D378 A:A:H362 14.2998.82NoNo079
65A:A:K233 B:B:Y145 40.82723.58YesYes698
66A:A:F246 A:A:I276 10.94875.02NoYes098
67A:A:K233 B:B:D228 38.67159.68YesYes699
68A:A:F246 A:A:F273 13.60638.57NoYes099
69R:R:K275 R:R:R507 36.41628.66YesYes057
70R:R:F503 R:R:R507 34.560916.03YesYes067
71R:R:F503 R:R:T266 33.28235.19YesNo067
72R:R:H288 R:R:T266 31.303912.32NoNo067
73R:R:H288 R:R:L499 30.476312.86NoNo069
74R:R:L499 R:R:Y495 22.554910.55NoYes099
75R:R:W470 R:R:Y495 21.54968.68YesYes1299
76R:R:M233 R:R:W470 23.81253.49YesYes089
77R:R:L325 R:R:M233 23.17544.24NoYes078
78R:R:L294 R:R:L325 22.85034.15NoNo087
79R:R:F229 R:R:L294 22.35873.65YesNo098
80R:R:F229 R:R:T489 21.53583.89YesNo097
81R:R:L248 R:R:T489 21.03974.42NoNo087
82R:R:L248 R:R:Y228 17.93348.21NoYes088
83R:R:L358 R:R:Y354 18.025519.93NoYes066
84R:R:I334 R:R:L358 17.74738.56NoNo066
85R:R:I334 R:R:W331 16.92057.05NoYes069
86R:R:L287 R:R:L499 10.22865.54NoNo099
87R:R:L287 R:R:S290 10.09984.5NoYes097
88R:R:G362 R:R:W331 23.60727.04NoYes1079
89R:R:G362 R:R:P366 15.89274.06NoYes1079
90R:R:L326 R:R:P366 14.99674.93NoYes099
91R:R:H322 R:R:L326 14.590611.57YesNo099
92B:B:L192 B:B:R150 27.61663.64YesNo056
93B:B:F199 B:B:L192 21.90423.65YesYes095
94B:B:F199 B:B:W211 13.227713.03YesYes1898
95B:B:D228 B:B:S227 37.82262.94YesNo696
96B:B:D247 B:B:S227 37.549110.31NoNo096
97B:B:D247 B:B:E226 18.461912.99NoNo093
98B:B:E226 B:B:R251 18.1493.49NoYes038
99B:B:F253 B:B:R251 30.586.41YesYes168
100B:B:F222 B:B:F253 15.9518.57YesYes186
101B:B:D247 B:B:T249 18.78025.78NoNo096
102B:B:R251 B:B:T249 18.15433.88YesNo086
103B:B:D333 B:B:S331 37.77775.89YesNo099
104B:B:H311 B:B:S331 37.6219.76YesNo099
105B:B:H311 B:B:T329 18.56628.21YesNo098
106B:B:T329 B:B:W339 18.06428.49NoYes089
107B:B:M45 B:B:W339 34.76433.49NoYes449
108B:B:M45 G:G:L50 34.45514.24NoNo449
109G:G:D48 G:G:L50 33.75365.43YesNo499
110G:G:D48 G:G:L51 33.060512.21YesYes496
111B:B:R283 G:G:L51 32.02783.64YesYes496
112B:B:L300 B:B:R283 25.0427.29YesYes069
113B:B:L30 B:B:L300 23.98764.15NoYes056
114B:B:H311 B:B:K337 18.389310.48YesYes096
115B:B:K337 B:B:W339 18.08329.28YesYes469
116B:B:L30 B:B:M262 20.46097.07NoNo054
117B:B:M262 B:B:Y264 19.753310.78NoYes045
118B:B:F241 B:B:F253 12.75476.43YesYes166
119B:B:F241 B:B:V200 10.22211.8YesYes166
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7EQ1
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRG5
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 3.3
Date 2022-05-11
D.O.I. 10.1038/s41586-022-04619-y
Net Summary
Imin 3.44
Number of Linked Nodes 867
Number of Links 1008
Number of Hubs 141
Number of Links mediated by Hubs 530
Number of Communities 32
Number of Nodes involved in Communities 192
Number of Links involved in Communities 253
Path Summary
Number Of Nodes in MetaPath 120
Number Of Links MetaPath 119
Number of Shortest Paths 1621825
Length Of Smallest Path 3
Average Path Length 32.4777
Length of Longest Path 67
Minimum Path Strength 0.97
Average Path Strength 7.26825
Maximum Path Strength 19.385
Minimum Path Correlation 0.7
Average Path Correlation 0.981858
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.22581
Average % Of Corr. Nodes 43.9063
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.1392
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7EQ1_Chain_A
CTLSAEDKA AVERSKMIE KQLQKDKQV YRATHRLLL LGADNSGKS 
TIVKQMRIY HVKTSGIFE TKFQVDKVN FHMFDVGAQ RDERRKWIQ 
CFNDVTAII FVVDSSDYN RLQEALNDF KSIWNNRWL RTISVILFL 
NKQDLLAEK VLAGKSKIE DYFPEFARY TTPEDATPE PGEDPRVTR 
AKYFIRDEF LRISTASGD GRHYCYPHF TCSVDTENA RRIFNDCRD 
IIQRMHLRQ YEL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ8IZF4
Sequence
>7EQ1_Chain_R
TYFAVLMQL SPALVPAEL LAPLTYISL VGCSISIVA SLITVLLHF 
HFRKQSDSL TRIHMNLHA SVLLLNIAF LLSPAFAMS PVPGSACTA 
LAAALHYAL LSCLTWMAI EGFNLYLLL GRVYNIYIR RYVFKLGVL 
GWGAPALLV LLSLSVKSS VYGPCTIPV FDSWENGTG FQNMSICWV 
RSPVVHSVL VMGYGGLTS LFNLVVLAW ALWTLRRLR EHDTVTVLG 
LTVLLGTTW ALAFFSFGV FLLPQLFLF TILNSLYGF FLFLWFCSQ 
RCRSEAEAK AQIEA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>7EQ1_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>7EQ1_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7EQ1B2AdhesionAdhesionADGRG5Homo sapiens--chim(NtGi1-Gs)/&β;1/&γ;23.32022-05-1110.1038/s41586-022-04619-y




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7EQ1.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.