Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L30 3.1675445
2A:A:L45 5.9525428
3A:A:N50 7.113336109
4A:A:I207 4.888519
5A:A:F212 6.34529
6A:A:V217 5.8475425
7A:A:F219 5.21528
8A:A:M221 4.18528
9A:A:F222 8.695617
10A:A:Q227 5.5725419
11A:A:R232 8.8175418
12A:A:K233 6.27571719
13A:A:W234 6.56167619
14A:A:F238 8.554519
15A:A:I244 3.208518
16A:A:I245 3.066527
17A:A:F246 5.402519
18A:A:V248 4.12417
19A:A:D249 9.9254108
20A:A:D252 7.97754108
21A:A:Y253 5.9425408
22A:A:R265 6.23754109
23A:A:L270 6.445406
24A:A:F273 5.80286719
25A:A:I276 5.275408
26A:A:W277 6.98571716
27A:A:W281 8.62667615
28A:A:L282 7.7275419
29A:A:I288 5.29409
30A:A:L289 3.84519
31A:A:F290 6.28667629
32A:A:L291 3.79167618
33A:A:N292 4.058509
34A:A:Q294 7.2725416
35A:A:I308 5.8125417
36A:A:F312 6.0575418
37A:A:F315 7.135416
38A:A:P321 6.6925405
39A:A:Y339 7.365613
40A:A:F340 5.658517
41A:A:I341 3.0375418
42A:A:R342 5.59614
43A:A:E344 8.565415
44A:A:F345 6.60167618
45A:A:L346 4.7025414
46A:A:S349 3.962517
47A:A:C359 3.71615
48A:A:Y360 8.7525498
49A:A:F363 7.042515
50A:A:N371 6.534529
51A:A:R374 7.5575424
52A:A:F376 8.116528
53A:A:C379 4.44428
54A:A:I383 4.508528
55A:A:R385 7.2675495
56A:A:Y391 5.97534
57B:B:I18 4.6425417
58B:B:L30 3.9375415
59B:B:V40 4.16167613
60B:B:M45 3.7225414
61B:B:L51 8.52449
62B:B:H54 9.576549
63B:B:L55 6.2406
64B:B:K57 9.6825419
65B:B:Y59 13.4375418
66B:B:M61 5.8125446
67B:B:W63 6.95647
68B:B:L70 5.246545
69B:B:V71 4.4275468
70B:B:S72 6.1575449
71B:B:Q75 7.91519
72B:B:I80 9.415448
73B:B:I81 4.86567
74B:B:W82 10.1029749
75B:B:Y85 11.1525444
76B:B:N88 5.5525407
77B:B:K89 6.83749
78B:B:H91 6.245465
79B:B:L95 6.042568
80B:B:W99 10.078519
81B:B:C103 3.825408
82B:B:Y105 4.90429766
83B:B:N110 6.505474
84B:B:Y111 6.126574
85B:B:V112 4.9325468
86B:B:C114 5.715468
87B:B:L117 4.805419
88B:B:N119 4.5419
89B:B:S122 4.156568
90B:B:I123 3.682576
91B:B:Y124 5.54857766
92B:B:L126 4.93465
93B:B:V133 6.0725464
94B:B:V135 4.75464
95B:B:E138 5.875466
96B:B:L139 6.4409
97B:B:H142 7.05143779
98B:B:Y145 6.73429718
99B:B:L146 3.83577
100B:B:R150 6.9925456
101B:B:L152 4.236553
102B:B:I157 3.11477
103B:B:V158 4.47455
104B:B:T159 5.478579
105B:B:S161 8.07479
106B:B:D163 8.165479
107B:B:T165 5.5075477
108B:B:C166 4.585458
109B:B:L168 3.41756
110B:B:W169 8.39429778
111B:B:F180 6.57857757
112B:B:H183 5.48333659
113B:B:D186 6.4725419
114B:B:V187 4.148559
115B:B:L190 4.734555
116B:B:L192 4.6975455
117B:B:F199 7.07333659
118B:B:V200 8.61416
119B:B:S201 4.2575459
120B:B:C204 6.105417
121B:B:D205 6.25459
122B:B:L210 4.394505
123B:B:W211 8.944558
124B:B:D212 5.09254149
125B:B:R219 5.11254145
126B:B:Q220 6.0675417
127B:B:F222 7.5425418
128B:B:H225 6.89625819
129B:B:D228 6.555619
130B:B:I229 4.1725417
131B:B:I232 5.4825418
132B:B:F234 6.158515
133B:B:F235 5.77816
134B:B:P236 6.03417
135B:B:N237 6.5525415
136B:B:F241 5.5175816
137B:B:T243 5.022518
138B:B:D246 7.01419
139B:B:D247 7.9419
140B:B:T249 4.3416
141B:B:R251 8.74833618
142B:B:F253 5.14286716
143B:B:D258 11.278517
144B:B:Y264 6.545615
145B:B:H266 6.14414
146B:B:I269 4.1325414
147B:B:F278 5.31571717
148B:B:R283 6.94619
149B:B:L284 3.4875415
150B:B:L285 5.56516
151B:B:Y289 7.96714717
152B:B:D290 6.87416
153B:B:N295 7.344516
154B:B:V296 4.5575405
155B:B:W297 5.62833618
156B:B:L300 4.88167616
157B:B:R304 6.785615
158B:B:L308 6.98417
159B:B:H311 8.8425419
160B:B:R314 12.9325418
161B:B:L318 3.47333616
162B:B:T329 6.03418
163B:B:W332 9.33714719
164B:B:D333 6.276519
165B:B:F335 5.5375404
166B:B:L336 5.638547
167B:B:K337 6.96616
168B:B:W339 7.88167619
169G:G:E22 6.5975419
170G:G:R27 5.352518
171G:G:Y40 6.3416
172G:G:D48 8.296519
173G:G:P49 4.2925407
174G:G:L51 4.595616
175G:G:V54 4.3854176
176G:G:N59 3.1625409
177G:G:F61 5.52833648
178R:R:T227 4.636509
179R:R:Y228 5.061437118
180R:R:F229 3.76143789
181R:R:M233 3.764588
182R:R:Q234 7.7225117
183R:R:V240 4.5654114
184R:R:P241 4.6405
185R:R:L245 4.77254113
186R:R:S252 3.595488
187R:R:C256 3.0425486
188R:R:D278 3.4325407
189R:R:L280 9.165407
190R:R:I283 5.2675438
191R:R:H284 10.3075438
192R:R:H288 7.65406
193R:R:S290 4.068537
194R:R:N295 5.1075487
195R:R:F298 2.945408
196R:R:H322 6.458336139
197R:R:L326 5.6975409
198R:R:W331 7.83286739
199R:R:M332 5.252589
200R:R:I334 5.35436
201R:R:E335 8.82439
202R:R:N338 5.9675407
203R:R:L339 4.575438
204R:R:L342 5.5407
205R:R:V346 6.425428
206R:R:Y347 7.37571727
207R:R:R353 3.5454204
208R:R:Y354 9.322536
209R:R:W363 7.39167639
210R:R:P366 4.0675439
211R:R:Y381 4.887139
212R:R:G382 2.5825405
213R:R:D390 5.9404
214R:R:M401 4.4925402
215R:R:W405 5.96754138
216R:R:V406 5.135138
217R:R:L415 5.054507
218R:R:Y419 5.195439
219R:R:W433 3.626214
220R:R:L438 3.7075496
221R:R:L441 6.4325494
222R:R:R442 4.386595
223R:R:L462 4.0425438
224R:R:T463 3.07254126
225R:R:W470 7.13689
226R:R:F486 6.7175408
227R:R:T489 3.6375487
228R:R:L494 2.7875407
229R:R:Y495 7.162589
230R:R:F497 3.59254185
231R:R:F500 4.2725188
232R:R:W502 5.15833637
233R:R:F503 5.7525196
234R:R:R507 8.9254197
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:W281 B:B:W332 16.2982.81YesYes159
2A:A:N279 A:A:W281 17.36425.65NoYes185
3A:A:I235 A:A:N279 15.97414.25NoNo198
4A:A:I235 A:A:W234 18.00353.52NoYes199
5A:A:W234 B:B:Y145 67.76926.75YesYes198
6B:B:G162 B:B:Y145 99.617310.14NoYes098
7B:B:G162 B:B:S161 99.69013.71NoYes099
8B:B:H142 B:B:S161 59.820916.74YesYes799
9B:B:H142 B:B:T159 20.11796.85YesYes799
10B:B:I157 B:B:T159 39.98763.04YesYes779
11B:B:I123 B:B:I157 60.08672.94YesYes767
12B:B:I123 B:B:Y111 1003.63YesYes764
13B:B:A106 B:B:Y111 98.94332.67NoYes064
14B:B:A106 B:B:F151 98.58989.71NoNo069
15B:B:A113 B:B:F151 98.41284.16NoNo099
16B:B:A113 B:B:C149 98.32433.61NoNo098
17B:B:C149 B:B:T102 98.23578.45NoNo088
18B:B:C148 B:B:T102 98.1473.38NoNo068
19B:B:C148 B:B:R150 90.90158.36NoYes566
20B:B:H62 B:B:R150 91.276613.54NoYes066
21B:B:H62 B:B:Y105 91.18433.27NoYes066
22B:B:L146 B:B:S161 39.75523YesYes779
23B:B:L146 B:B:T159 19.89384.42YesYes779
24B:B:H142 B:B:W169 40.27788.46YesYes798
25B:B:I157 B:B:W169 20.20823.52YesYes778
26B:B:L139 B:B:W169 20.208315.94YesYes098
27B:B:I123 B:B:L139 40.05172.85YesYes069
28B:B:C121 B:B:L146 19.89413.17NoYes787
29B:B:C121 B:B:L139 19.89143.17NoYes089
30B:B:V112 B:B:Y105 88.10863.79YesYes686
31B:B:V112 B:B:Y124 88.07973.79YesYes686
32B:B:S122 B:B:Y124 87.213.82YesYes686
33B:B:I120 B:B:S122 87.16433.1NoYes668
34B:B:D118 B:B:I120 87.11765.6NoNo096
35A:A:S205 B:B:D118 86.92984.42NoNo079
36A:A:F208 A:A:S205 86.83582.64NoNo057
37A:A:D223 A:A:F208 86.64772.39NoNo095
38A:A:D223 A:A:L45 86.33485.43NoYes298
39A:A:L45 A:A:M221 16.13497.07YesYes288
40A:A:F212 A:A:M221 15.14224.98YesYes298
41A:A:F212 A:A:F219 14.8988.57YesYes298
42A:A:F219 A:A:V217 22.31083.93YesYes285
43A:A:V217 R:R:N348 20.79962.96YesNo056
44R:R:N348 R:R:R345 20.59587.23NoNo066
45R:R:L341 R:R:R345 20.39214.86NoNo066
46R:R:L341 R:R:Y354 19.96825.86NoYes366
47A:A:I245 A:A:L45 70.13672.85YesYes278
48A:A:I245 A:A:L43 59.01082.85YesNo277
49A:A:F219 A:A:L43 14.7014.87YesNo287
50A:A:C379 A:A:T242 40.7723.38YesNo288
51A:A:C379 A:A:L43 44.20964.76YesNo287
52A:A:I383 A:A:T242 40.55816.08YesNo288
53A:A:F290 A:A:I245 11.66613.77YesYes297
54B:B:D246 B:B:G272 17.38855.03YesNo094
55B:B:D290 B:B:G272 17.20813.35YesNo064
56A:A:R231 A:A:W234 42.09525NoYes099
57A:A:I276 A:A:R231 21.01037.52YesNo089
58A:A:D272 A:A:R231 21.016410.72NoNo089
59A:A:D272 A:A:F246 20.8198.36NoYes089
60A:A:F246 A:A:I276 21.87145.02YesYes098
61A:A:K233 B:B:Y145 30.11323.58YesYes198
62A:A:K233 B:B:D228 21.13599.68YesYes199
63A:A:F246 A:A:F273 13.65958.57YesYes199
64A:A:F246 A:A:L289 21.63582.44YesYes199
65A:A:L289 A:A:L291 14.07314.15YesYes198
66A:A:F345 A:A:I341 13.89452.51YesYes188
67A:A:F340 A:A:I341 13.67442.51YesYes178
68A:A:H387 A:A:I383 40.55626.63NoYes088
69A:A:H387 R:R:L342 40.34659NoYes087
70A:A:Y391 R:R:L342 24.34453.52YesYes047
71R:R:L342 R:R:N338 10.98095.49YesYes077
72A:A:Y391 R:R:L462 22.43483.52YesYes348
73B:B:D247 B:B:S227 13.05910.31YesNo196
74B:B:D247 B:B:H225 11.95462.52YesYes199
75B:B:C271 B:B:D290 17.03393.11NoYes156
76B:B:C271 B:B:Y289 16.4364.03NoYes157
77B:B:W297 B:B:Y289 13.25149.65YesYes187
78R:R:L462 R:R:L466 22.45144.15YesNo089
79R:R:L466 R:R:N427 22.34295.49NoNo099
80R:R:M332 R:R:N427 22.2354.21YesNo099
81R:R:M332 R:R:W470 21.69418.14YesYes899
82R:R:F229 R:R:W470 20.46763.01YesYes899
83R:R:I283 R:R:N338 10.76387.08YesYes087
84R:R:L358 R:R:Y354 17.627619.93NoYes366
85R:R:I334 R:R:L358 17.32088.56YesNo366
86R:R:I334 R:R:W331 25.12097.05YesYes369
87R:R:G362 R:R:W331 15.24277.04NoYes379
88B:B:D228 B:B:S227 12.57042.94YesNo196
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7EQ1
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRG5
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 3.3
Date 2022-05-11
D.O.I. doi.org/10.1038/s41586-022-04619-y
Net Summary
Imin 2.39
Number of Linked Nodes 867
Number of Links 1178
Number of Hubs 234
Number of Links mediated by Hubs 812
Number of Communities 21
Number of Nodes involved in Communities 342
Number of Links involved in Communities 539
Path Summary
Number Of Nodes in MetaPath 89
Number Of Links MetaPath 88
Number of Shortest Paths 5698544
Length Of Smallest Path 3
Average Path Length 42.96
Length of Longest Path 70
Minimum Path Strength 0.97
Average Path Strength 5.69894
Maximum Path Strength 19.385
Minimum Path Correlation 0.7
Average Path Correlation 0.991983
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.08333
Average % Of Corr. Nodes 29.0927
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 56.2127
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• cytoskeletal protein binding   • spectrin binding   • protein-containing complex binding   • protein binding   • binding   • enzyme binding   • GTPase binding   • phosphoric ester hydrolase activity   • alkylglycerophosphoethanolamine phosphodiesterase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • hydrolase activity   • catalytic activity   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity, acting on acid anhydrides   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye
Gene OntologyBiological Process• positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • response to decreased oxygen levels   • cellular response to stimulus   • response to stimulus   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to chemical stimulus   • cellular response to stress   • response to hypoxia   • response to stress   • response to chemical   • response to oxygen levels   • response to abiotic stimulus   • cellular process   • cell population proliferation   • regulation of biological process   • regulation of cellular process   • signaling   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cell communication   • G protein-coupled receptor signaling pathway   • signal transduction   • muscle cell apoptotic process   • striated muscle cell apoptotic process   • apoptotic process   • cell death   • programmed cell death   • cardiac muscle cell apoptotic process   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cellular anatomical structure   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cellular anatomical structure   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • photoreceptor inner segment   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • intracellular anatomical structure   • cytoplasm   • membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor outer segment   • photoreceptor cell cilium   • organelle   • ciliary membrane   • photoreceptor outer segment membrane   • bounding membrane of organelle   • plasma membrane region   • organelle membrane   • cell projection membrane   • synapse   • cell junction   • cell body   • protein binding   • binding   • G-protein beta-subunit binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • cellular process   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • cell surface receptor signaling pathway   • peptide hormone receptor binding   • corticotropin-releasing hormone receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • corticotropin-releasing hormone receptor 1 binding   • hormone receptor binding   • neuropeptide receptor binding   • mu-type opioid receptor binding   • opioid receptor binding   • beta-2 adrenergic receptor binding   • adrenergic receptor binding   • D1 dopamine receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • ionotropic glutamate receptor binding   • glutamate receptor binding   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • molecular function regulator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • metal ion binding   • insulin-like growth factor receptor binding   • magnesium ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • regulation of protein localization   • positive regulation of biological process   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of protein localization to cell cortex   • macromolecule localization   • positive regulation of protein localization   • intracellular protein localization   • protein localization to cell cortex   • cell division   • cellular response to forskolin   • response to forskolin   • midbody   • cell cortex   • intracellular organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • membraneless organelle   • intracellular membraneless organelle   • microtubule cytoskeleton   • nucleus   • intracellular membrane-bounded organelle
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7EQ1_Chain_A
CTLSAEDKA AVERSKMIE KQLQKDKQV YRATHRLLL LGADNSGKS 
TIVKQMRIY HVKTSGIFE TKFQVDKVN FHMFDVGAQ RDERRKWIQ 
CFNDVTAII FVVDSSDYN RLQEALNDF KSIWNNRWL RTISVILFL 
NKQDLLAEK VLAGKSKIE DYFPEFARY TTPEDATPE PGEDPRVTR 
AKYFIRDEF LRISTASGD GRHYCYPHF TCSVDTENA RRIFNDCRD 
IIQRMHLRQ YEL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>7EQ1_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>7EQ1_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ8IZF4
Sequence
>7EQ1_Chain_R
TYFAVLMQL SPALVPAEL LAPLTYISL VGCSISIVA SLITVLLHF 
HFRKQSDSL TRIHMNLHA SVLLLNIAF LLSPAFAMS PVPGSACTA 
LAAALHYAL LSCLTWMAI EGFNLYLLL GRVYNIYIR RYVFKLGVL 
GWGAPALLV LLSLSVKSS VYGPCTIPV FDSWENGTG FQNMSICWV 
RSPVVHSVL VMGYGGLTS LFNLVVLAW ALWTLRRLR EHDTVTVLG 
LTVLLGTTW ALAFFSFGV FLLPQLFLF TILNSLYGF FLFLWFCSQ 
RCRSEAEAK AQIEA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7EQ1B2AdhesionAdhesionADGRG5Homo sapiens--chim(NtGi1-Gs)/β1/γ23.32022-05-11doi.org/10.1038/s41586-022-04619-y
7EQ1 (No Gprot) B2AdhesionAdhesionADGRG5Homo sapiens--3.32022-05-11doi.org/10.1038/s41586-022-04619-y




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