psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T227	R:R:V231	4.76	Yes	No	0	9	7
2	R:R:P302	R:R:T227	5.25	No	Yes	0	5	9
3	R:R:M401	R:R:T227	6.02	Yes	Yes	0	2	9
4	R:R:I403	R:R:T227	4.56	No	Yes	0	4	9
5	R:R:V231	R:R:Y228	10.09	No	Yes	0	7	8
6	R:R:Q234	R:R:Y228	3.38	Yes	Yes	0	7	8
7	R:R:V240	R:R:Y228	3.79	Yes	Yes	0	4	8
8	R:R:L248	R:R:Y228	8.21	No	Yes	0	8	8
9	R:R:M401	R:R:Y228	4.79	Yes	Yes	0	2	8
10	R:R:F229	R:R:S252	3.96	Yes	Yes	4	9	8
11	R:R:F229	R:R:L294	3.65	Yes	No	0	9	8
12	R:R:F229	R:R:T489	3.89	Yes	Yes	4	9	7
13	R:R:F229	R:R:S493	6.61	Yes	No	4	9	8
14	R:R:L325	R:R:M233	4.24	No	Yes	0	7	8
15	R:R:M233	R:R:W470	3.49	Yes	Yes	1	8	9
16	R:R:A473	R:R:M233	3.22	No	Yes	1	8	8
17	R:R:F488	R:R:M233	4.98	No	Yes	1	9	8
18	R:R:P237	R:R:Q234	20.53	No	Yes	0	2	7
19	R:R:Q234	R:R:Q484	7.68	Yes	No	0	7	6
20	R:R:L485	R:R:Q234	3.99	No	Yes	0	6	7
21	R:R:L235	R:R:S476	6.01	No	No	0	4	6
22	R:R:P237	R:R:S476	3.56	No	No	0	2	6
23	R:R:F389	R:R:L239	8.53	No	No	0	1	1
24	R:R:P241	R:R:V240	5.3	Yes	Yes	0	5	4
25	R:R:L245	R:R:V240	5.96	Yes	Yes	6	3	4
26	R:R:V240	R:R:V388	3.21	Yes	No	6	4	4
27	R:R:L244	R:R:P241	8.21	No	Yes	0	4	5
28	R:R:L481	R:R:P241	3.28	No	Yes	0	5	5
29	R:R:F486	R:R:L244	7.31	No	No	0	8	4
30	R:R:L245	R:R:T249	4.42	Yes	No	0	3	5
31	R:R:L245	R:R:V388	4.47	Yes	No	6	3	4
32	R:R:L245	R:R:M401	4.24	Yes	Yes	0	3	2
33	R:R:F486	R:R:L248	12.18	No	No	0	8	8
34	R:R:L248	R:R:T489	4.42	No	Yes	0	8	7
35	R:R:F298	R:R:S252	3.96	No	Yes	0	8	8
36	R:R:S252	R:R:T489	3.2	Yes	Yes	4	8	7
37	R:R:S252	R:R:S493	3.26	Yes	No	4	8	8
38	R:R:G255	R:R:L494	3.42	No	Yes	0	9	7
39	R:R:C256	R:R:N295	3.15	No	No	0	6	7
40	R:R:C256	R:R:S493	3.44	No	No	0	6	8
41	R:R:N295	R:R:S259	10.43	No	No	0	7	9
42	R:R:G496	R:R:S259	3.71	No	No	0	9	9
43	R:R:A262	R:R:F500	4.16	No	Yes	0	7	8
44	R:R:L292	R:R:S263	9.01	No	No	0	5	8
45	R:R:L264	R:R:L292	4.15	No	No	0	4	5
46	R:R:F500	R:R:I265	5.02	Yes	No	0	8	5
47	R:R:H288	R:R:T266	12.32	No	No	0	6	7
48	R:R:F500	R:R:T266	6.49	Yes	No	0	8	7
49	R:R:F503	R:R:T266	5.19	Yes	No	0	6	7
50	R:R:F271	R:R:H270	5.66	No	No	0	3	7
51	R:R:H270	R:R:M285	19.7	No	No	0	7	6
52	R:R:F271	R:R:R274	9.62	No	No	0	3	7
53	R:R:F273	R:R:H272	12.44	No	No	0	6	4
54	R:R:D278	R:R:K275	4.15	No	No	0	7	5
55	R:R:K275	R:R:R507	8.66	No	Yes	0	5	7
56	R:R:R282	R:R:S277	7.91	No	No	0	6	7
57	R:R:H284	R:R:L280	10.29	Yes	No	0	8	7
58	R:R:L280	R:R:N338	5.49	No	Yes	0	7	7
59	R:R:R507	R:R:T281	5.17	Yes	No	0	7	7
60	R:R:R282	R:R:R353	4.26	No	Yes	7	6	4
61	R:R:R282	R:R:V355	10.46	No	No	7	6	5
62	R:R:E335	R:R:I283	8.2	No	No	0	9	8
63	R:R:I283	R:R:N338	7.08	No	Yes	0	8	7
64	R:R:E335	R:R:H284	9.85	No	Yes	5	9	8
65	R:R:H284	R:R:L465	11.57	Yes	No	5	8	8
66	R:R:H284	R:R:W502	9.52	Yes	Yes	5	8	7
67	R:R:F503	R:R:M285	3.73	Yes	No	0	6	6
68	R:R:N286	R:R:W331	15.82	No	Yes	2	9	9
69	R:R:N286	R:R:W363	4.52	No	Yes	2	9	9
70	R:R:L287	R:R:S290	4.5	No	Yes	0	9	7
71	R:R:L287	R:R:L499	5.54	No	No	0	9	9
72	R:R:H288	R:R:L499	12.86	No	No	0	6	9
73	R:R:S290	R:R:S327	3.26	Yes	No	2	7	7
74	R:R:C328	R:R:S290	5.16	No	Yes	0	6	7
75	R:R:S290	R:R:W331	3.71	Yes	Yes	2	7	9
76	R:R:S290	R:R:W363	3.71	Yes	Yes	2	7	9
77	R:R:N295	R:R:V291	4.43	No	No	0	7	8
78	R:R:V291	R:R:Y495	5.05	No	Yes	0	8	9
79	R:R:A324	R:R:L293	4.73	No	No	0	8	5
80	R:R:A324	R:R:L294	3.15	No	No	0	8	8
81	R:R:L294	R:R:L325	4.15	No	No	0	8	7
82	R:R:A297	R:R:L321	3.15	No	No	0	5	8
83	R:R:P302	R:R:S301	3.56	No	No	0	5	6
84	R:R:I403	R:R:S301	7.74	No	No	0	4	6
85	R:R:C314	R:R:F304	5.59	No	No	0	9	5
86	R:R:F304	R:R:L317	6.09	No	No	0	5	6
87	R:R:P308	R:R:S307	5.34	No	No	0	3	4
88	R:R:P310	R:R:V309	3.53	No	No	0	4	1
89	R:R:A313	R:R:P310	5.61	No	No	0	3	4
90	R:R:S312	R:R:T315	3.2	No	No	0	3	4
91	R:R:C314	R:R:C404	7.28	No	No	0	9	9
92	R:R:A318	R:R:Y381	4	No	Yes	0	9	9
93	R:R:L321	R:R:W405	9.11	No	Yes	0	8	8
94	R:R:H322	R:R:L326	11.57	Yes	No	0	9	9
95	R:R:H322	R:R:Y381	10.89	Yes	Yes	3	9	9
96	R:R:H322	R:R:W405	4.23	Yes	Yes	3	9	8
97	R:R:H322	R:R:V406	4.15	Yes	Yes	3	9	8
98	R:R:H322	R:R:L415	5.14	Yes	Yes	0	9	7
99	R:R:W363	R:R:Y323	7.72	Yes	No	0	9	7
100	R:R:L326	R:R:P366	4.93	No	Yes	0	9	9
101	R:R:L326	R:R:Y419	3.52	No	No	0	9	9
102	R:R:S327	R:R:W363	9.88	No	Yes	2	7	9
103	R:R:C328	R:R:M332	3.24	No	Yes	0	6	9
104	R:R:L329	R:R:Y419	3.52	No	No	0	8	9
105	R:R:L329	R:R:T423	4.42	No	No	0	8	8
106	R:R:G362	R:R:T330	3.64	No	No	2	7	6
107	R:R:P366	R:R:T330	5.25	Yes	No	2	9	6
108	R:R:T330	R:R:Y419	11.24	No	No	0	6	9
109	R:R:I334	R:R:W331	7.05	No	Yes	0	6	9
110	R:R:G362	R:R:W331	7.04	No	Yes	2	7	9
111	R:R:W331	R:R:W363	15.93	Yes	Yes	2	9	9
112	R:R:M332	R:R:N427	4.21	Yes	No	0	9	9
113	R:R:G467	R:R:M332	3.49	No	Yes	1	9	9
114	R:R:M332	R:R:W470	8.14	Yes	Yes	1	9	9
115	R:R:M332	R:R:Y495	7.18	Yes	Yes	1	9	9
116	R:R:A333	R:R:T423	3.36	No	No	0	7	8
117	R:R:I334	R:R:L358	8.56	No	No	0	6	6
118	R:R:E335	R:R:L465	14.58	No	No	5	9	8
119	R:R:F337	R:R:L341	7.31	No	Yes	8	5	6
120	R:R:F337	R:R:Y354	4.13	No	Yes	8	5	6
121	R:R:L342	R:R:N338	5.49	No	Yes	0	7	7
122	R:R:N338	R:R:Y354	5.81	Yes	Yes	0	7	6
123	R:R:L339	R:R:L462	6.92	No	No	9	8	8
124	R:R:W433	R:R:Y340	4.82	Yes	No	0	4	7
125	R:R:L341	R:R:R345	4.86	Yes	No	0	6	6
126	R:R:L341	R:R:Y354	5.86	Yes	Yes	8	6	6
127	R:R:L343	R:R:W433	3.42	No	Yes	0	6	4
128	R:R:N348	R:R:R345	7.23	No	No	0	6	6
129	R:R:I351	R:R:Y354	10.88	No	Yes	0	6	6
130	R:R:I351	R:R:K357	5.82	No	No	0	6	7
131	R:R:K357	R:R:R352	3.71	No	No	0	7	4
132	R:R:R353	R:R:V355	6.54	Yes	No	7	4	5
133	R:R:L358	R:R:Y354	19.93	No	Yes	0	6	6
134	R:R:F356	R:R:V360	6.55	No	No	0	4	3
135	R:R:A365	R:R:L361	3.15	No	No	0	4	4
136	R:R:G362	R:R:P366	4.06	No	Yes	2	7	9
137	R:R:L369	R:R:L415	9.69	No	Yes	0	6	7
138	R:R:V370	R:R:Y381	3.79	No	Yes	0	8	9
139	R:R:K377	R:R:V376	6.07	No	No	0	4	4
140	R:R:V380	R:R:Y381	7.57	No	Yes	0	5	9
141	R:R:S408	R:R:V380	6.46	No	No	0	3	5
142	R:R:V380	R:R:V411	3.21	No	No	0	5	5
143	R:R:V406	R:R:Y381	3.79	Yes	Yes	3	8	9
144	R:R:G382	R:R:P383	4.06	Yes	No	0	5	1
145	R:R:C384	R:R:R407	4.18	No	No	0	2	5
146	R:R:S402	R:R:T385	4.8	No	No	0	2	4
147	R:R:I386	R:R:P387	5.08	No	No	0	6	3
148	R:R:D390	R:R:W392	18.98	Yes	No	0	4	2
149	R:R:E393	R:R:G395	3.27	No	No	0	6	6
150	R:R:G395	R:R:T396	5.46	No	No	0	6	7
151	R:R:V406	R:R:W405	7.36	Yes	Yes	3	8	8
152	R:R:H412	R:R:W405	3.17	No	Yes	3	6	8
153	R:R:V406	R:R:V411	4.81	Yes	No	0	8	5
154	R:R:H412	R:R:V406	5.54	No	Yes	3	6	8
155	R:R:L415	R:R:V411	5.96	Yes	No	0	7	5
156	R:R:H412	R:R:V416	8.3	No	No	0	6	8
157	R:R:A471	R:R:S424	3.42	No	No	0	5	7
158	R:R:F426	R:R:V430	7.87	No	No	0	4	6
159	R:R:L466	R:R:N427	5.49	No	No	0	9	9
160	R:R:L428	R:R:T468	4.42	No	No	0	3	6
161	R:R:A471	R:R:L428	3.15	No	No	0	5	3
162	R:R:L431	R:R:T468	4.42	No	No	0	7	6
163	R:R:T437	R:R:W433	7.28	No	Yes	0	6	4
164	R:R:L435	R:R:V459	5.96	No	No	0	5	6
165	R:R:R440	R:R:W436	12	No	No	0	4	3
166	R:R:D455	R:R:L438	8.14	No	No	0	6	6
167	R:R:L441	R:R:R442	3.64	No	No	0	4	5
168	R:R:D455	R:R:R442	4.76	No	No	0	6	5
169	R:R:H454	R:R:T456	8.21	No	No	0	5	4
170	R:R:L462	R:R:L466	4.15	No	No	0	8	9
171	R:R:T463	R:R:T468	6.28	No	No	0	6	6
172	R:R:L465	R:R:W502	4.56	No	Yes	5	8	7
173	R:R:G467	R:R:Y495	4.35	No	Yes	1	9	9
174	R:R:T469	R:R:W470	3.64	No	Yes	1	8	9
175	R:R:L491	R:R:T469	7.37	No	No	0	6	8
176	R:R:N492	R:R:T469	8.77	No	No	1	9	8
177	R:R:N492	R:R:W470	15.82	No	Yes	1	9	9
178	R:R:W470	R:R:Y495	8.68	Yes	Yes	1	9	9
179	R:R:L472	R:R:L487	5.54	No	No	0	7	5
180	R:R:A473	R:R:F488	4.16	No	No	1	8	9
181	R:R:F475	R:R:F480	8.57	No	No	0	6	3
182	R:R:Q484	R:R:S476	7.22	No	No	0	6	6
183	R:R:F480	R:R:V479	5.24	No	No	0	3	4
184	R:R:F480	R:R:P483	4.33	No	No	0	3	4
185	R:R:F486	R:R:L482	4.87	No	No	0	8	2
186	R:R:L487	R:R:L491	6.92	No	No	0	5	6
187	R:R:F488	R:R:N492	16.92	No	No	1	9	9
188	R:R:L499	R:R:Y495	10.55	No	Yes	0	9	9
189	R:R:F497	R:R:F500	4.29	No	Yes	0	5	8
190	R:R:F497	R:R:L501	4.87	No	No	0	5	6
191	R:R:Q506	R:R:W502	5.48	No	Yes	0	5	7
192	R:R:F503	R:R:R507	16.03	Yes	Yes	0	6	7
193	R:R:Q506	R:R:R507	5.84	No	Yes	0	5	7
194	R:R:E513	R:R:R509	3.49	No	No	0	7	5
195	R:R:E511	R:R:K515	4.05	No	No	0	6	5
196	R:R:I518	R:R:Q517	5.49	No	No	0	1	4
197	R:R:E519	R:R:I518	4.1	No	No	0	5	1
198	R:R:I251	R:R:T489	3.04	No	Yes	0	8	7
199	R:R:A230	R:R:Q234	3.03	No	Yes	0	9	7
200	R:R:F474	R:R:G421	3.01	No	No	0	5	3
201	R:R:L317	R:R:S301	3	No	No	0	6	6
202	R:R:G382	R:R:R407	3	Yes	No	0	5	5
203	R:R:L415	R:R:V414	2.98	Yes	No	0	7	6
204	R:R:I251	R:R:I490	2.94	No	No	0	8	7
205	R:R:I260	R:R:I296	2.94	No	No	0	6	5
206	R:R:I386	R:R:M401	2.92	No	Yes	0	6	2
207	R:R:G344	R:R:Y340	2.9	No	No	0	7	7
208	R:R:M233	R:R:M417	2.89	Yes	No	0	8	6
209	R:R:I258	R:R:L494	2.85	No	Yes	0	7	7
210	R:R:I260	R:R:L292	2.85	No	No	0	6	5
211	R:R:I334	R:R:L361	2.85	No	No	0	6	4
212	R:R:G359	R:R:W331	2.81	No	Yes	0	4	9
213	R:R:G461	R:R:W502	2.81	No	Yes	0	7	7
214	R:R:H288	R:R:S263	2.79	No	No	0	6	8
215	R:R:L232	R:R:L325	2.77	No	No	0	9	7
216	R:R:A238	R:R:F389	2.77	No	No	0	1	1
217	R:R:L339	R:R:L343	2.77	No	No	0	8	6
218	R:R:H454	R:R:V457	2.77	No	No	0	5	6
219	R:R:E519	R:R:K515	2.7	No	No	0	5	5
220	R:R:A319	R:R:Y381	2.67	No	Yes	0	5	9
221	R:R:A367	R:R:Y323	2.67	No	No	0	5	7
222	R:R:F474	R:R:S424	2.64	No	No	0	5	7
223	R:R:F271	R:R:V267	2.62	No	No	0	3	7
224	R:R:A289	R:R:W363	2.59	No	Yes	0	4	9
225	R:R:V346	R:R:Y347	2.52	No	No	0	8	7
226	R:R:V430	R:R:W433	2.45	No	Yes	0	6	4
227	R:R:F273	R:R:L269	2.44	No	No	0	6	8
228	R:R:F497	R:R:L494	2.44	No	Yes	0	5	7
229	R:R:F498	R:R:L494	2.44	No	Yes	0	6	7
230	R:R:L253	R:R:Y250	2.34	No	No	0	4	4
231	R:R:E443	R:R:R440	2.33	No	No	0	3	4
232	R:R:F356	R:R:R353	2.14	No	Yes	0	4	4
233	R:R:G420	R:R:G421	2.11	No	No	0	7	3
234	R:R:G364	R:R:P366	2.03	No	Yes	0	7	9
235	R:R:A246	R:R:P247	1.87	No	No	0	1	3
236	R:R:G255	R:R:V254	1.84	No	No	0	9	7
237	R:R:G336	R:R:V430	1.84	No	No	0	7	6
238	R:R:G382	R:R:T315	1.82	Yes	No	0	5	4
239	R:R:P409	R:R:S408	1.78	No	No	0	3	3
240	R:R:C508	R:R:S505	1.72	No	No	0	5	5
241	R:R:A305	R:R:S402	1.71	No	No	0	5	2
242	R:R:G420	R:R:L329	1.71	No	No	0	7	8
243	R:R:G397	R:R:N394	1.7	No	No	0	5	5
244	R:R:M306	R:R:P308	1.68	No	No	0	3	3
245	R:R:L482	R:R:P483	1.64	No	No	0	2	4
246	R:R:N400	R:R:P387	1.63	No	No	0	5	3
247	R:R:D390	R:R:P241	1.61	Yes	Yes	0	4	5
248	R:R:A305	R:R:M306	1.61	No	No	0	5	3
249	R:R:T458	R:R:V459	1.59	No	No	0	7	6
250	R:R:T463	R:R:V464	1.59	No	No	0	6	6
251	R:R:A434	R:R:L339	1.58	No	No	9	8	8
252	R:R:A434	R:R:L462	1.58	No	No	9	8	8
253	R:R:A242	R:R:D390	1.54	No	Yes	0	1	4
254	R:R:I258	R:R:V261	1.54	No	No	0	7	4
255	R:R:I265	R:R:V261	1.54	No	No	0	5	4
256	R:R:K275	R:R:S510	1.53	No	No	0	5	6
257	R:R:K377	R:R:S373	1.53	No	No	0	4	8
258	R:R:F398	R:R:G397	1.51	No	No	0	5	5
259	R:R:F477	R:R:G478	1.51	No	No	0	5	5
260	R:R:A514	R:R:E511	1.51	No	No	0	4	6
261	R:R:L372	R:R:S373	1.5	No	No	0	6	8
262	R:R:L415	R:R:S373	1.5	Yes	No	0	7	8
263	R:R:L371	R:R:V370	1.49	No	No	0	4	8
264	R:R:L438	R:R:V459	1.49	No	No	0	6	6
265	R:R:N394	R:R:V388	1.48	No	No	0	5	4
266	R:R:D278	R:R:S279	1.47	No	No	0	7	4
267	R:R:D390	R:R:S391	1.47	Yes	No	0	4	6
268	R:R:L460	R:R:T463	1.47	No	No	0	5	6
269	R:R:N400	R:R:T385	1.46	No	No	0	5	4
270	R:R:G382	R:R:Y381	1.45	Yes	Yes	0	5	9
271	R:R:I349	R:R:L341	1.43	No	Yes	0	5	6
272	R:R:I349	R:R:L342	1.43	No	No	0	5	7
273	R:R:C504	R:R:F500	1.4	No	Yes	0	7	8
274	R:R:C508	R:R:R509	1.39	No	No	0	5	5
275	R:R:L239	R:R:L481	1.38	No	No	0	1	5
276	R:R:L253	R:R:L299	1.38	No	No	0	4	7
277	R:R:L299	R:R:L300	1.38	No	No	0	7	4
278	R:R:L300	R:R:L317	1.38	No	No	0	4	6
279	R:R:L371	R:R:L374	1.38	No	No	0	4	5
280	R:R:E243	R:R:L244	1.33	No	No	0	1	4
281	R:R:R407	R:R:S379	1.32	No	No	0	5	4
282	R:R:F304	R:R:V309	1.31	No	No	0	5	1
283	R:R:K357	R:R:R353	1.24	No	Yes	0	7	4
284	R:R:F477	R:R:L235	1.22	No	No	0	5	4
285	R:R:F503	R:R:L269	1.22	Yes	No	0	6	8
286	R:R:N348	R:R:Y347	1.16	No	No	0	6	7
287	R:R:R439	R:R:W436	1	No	No	0	3	3
288	R:R:W433	R:R:W436	0.94	Yes	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T227	5.1475	4	0	9
2	R:R:Y228	6.052	5	0	8
3	R:R:F229	4.5275	4	4	9
4	R:R:M233	3.764	5	1	8
5	R:R:Q234	7.722	5	0	7
6	R:R:V240	4.565	4	6	4
7	R:R:P241	4.6	4	0	5
8	R:R:L245	4.7725	4	6	3
9	R:R:S252	3.595	4	4	8
10	R:R:H284	10.3075	4	5	8
11	R:R:S290	4.068	5	2	7
12	R:R:H322	7.196	5	3	9
13	R:R:W331	8.72667	6	2	9
14	R:R:M332	5.252	5	1	9
15	R:R:N338	5.9675	4	0	7
16	R:R:L341	4.865	4	8	6
17	R:R:R353	3.545	4	7	4
18	R:R:Y354	9.322	5	8	6
19	R:R:W363	7.39167	6	2	9
20	R:R:P366	4.0675	4	2	9
21	R:R:Y381	4.88	7	3	9
22	R:R:G382	2.5825	4	0	5
23	R:R:D390	5.9	4	0	4
24	R:R:M401	4.4925	4	0	2
25	R:R:W405	5.9675	4	3	8
26	R:R:V406	5.13	5	3	8
27	R:R:L415	5.054	5	0	7
28	R:R:W433	3.782	5	0	4
29	R:R:W470	7.954	5	1	9
30	R:R:T489	3.6375	4	4	7
31	R:R:L494	2.7875	4	0	7
32	R:R:Y495	7.162	5	1	9
33	R:R:F500	4.272	5	0	8
34	R:R:W502	5.5925	4	5	7
35	R:R:F503	6.5425	4	0	6
36	R:R:R507	8.925	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T227	R:R:V231	26.4694	4.76	Yes	No	0	9	7
2	R:R:V231	R:R:Y228	27.3948	10.09	No	Yes	0	7	8
3	R:R:Q234	R:R:Y228	15.1227	3.38	Yes	Yes	0	7	8
4	R:R:M401	R:R:Y228	38.0637	4.79	Yes	Yes	0	2	8
5	R:R:M401	R:R:T227	28.7784	6.02	Yes	Yes	0	2	9
6	R:R:V240	R:R:Y228	17.2429	3.79	Yes	Yes	0	4	8
7	R:R:L248	R:R:Y228	86.7127	8.21	No	Yes	0	8	8
8	R:R:F229	R:R:T489	81.8874	3.89	Yes	Yes	4	9	7
9	R:R:L248	R:R:T489	100	4.42	No	Yes	0	8	7
10	R:R:S252	R:R:T489	19.6323	3.2	Yes	Yes	4	8	7
11	R:R:F229	R:R:L294	64.0503	3.65	Yes	No	0	9	8
12	R:R:F229	R:R:S493	19.1959	6.61	Yes	No	4	9	8
13	R:R:S252	R:R:S493	20.4494	3.26	Yes	No	4	8	8
14	R:R:L294	R:R:L325	64.4495	4.15	No	No	0	8	7
15	R:R:L325	R:R:M233	64.7002	4.24	No	Yes	0	7	8
16	R:R:M233	R:R:W470	64.7467	3.49	Yes	Yes	1	8	9
17	R:R:P241	R:R:V240	12.1978	5.3	Yes	Yes	0	5	4
18	R:R:F486	R:R:L244	10.4553	7.31	No	No	0	8	4
19	R:R:F486	R:R:L248	17.0107	12.18	No	No	0	8	8
20	R:R:F497	R:R:F500	11.7645	4.29	No	Yes	0	5	8
21	R:R:F500	R:R:T266	21.6844	6.49	Yes	No	0	8	7
22	R:R:H288	R:R:T266	52.3167	12.32	No	No	0	6	7
23	R:R:H288	R:R:L499	60.6735	12.86	No	No	0	6	9
24	R:R:L499	R:R:Y495	56.7025	10.55	No	Yes	0	9	9
25	R:R:V291	R:R:Y495	39.831	5.05	No	Yes	0	8	9
26	R:R:N295	R:R:V291	39.7908	4.43	No	No	0	7	8
27	R:R:C256	R:R:N295	39.6793	3.15	No	No	0	6	7
28	R:R:C256	R:R:S493	39.6484	3.44	No	No	0	6	8
29	R:R:W470	R:R:Y495	19.3661	8.68	Yes	Yes	1	9	9
30	R:R:F503	R:R:T266	32.8175	5.19	Yes	No	0	6	7
31	R:R:F503	R:R:R507	20.1028	16.03	Yes	Yes	0	6	7
32	R:R:L358	R:R:Y354	19.004	19.93	No	Yes	0	6	6
33	R:R:I334	R:R:L358	19.7159	8.56	No	No	0	6	6
34	R:R:I334	R:R:W331	21.9536	7.05	No	Yes	0	6	9
35	R:R:S290	R:R:W331	53.6352	3.71	Yes	Yes	2	7	9
36	R:R:C328	R:R:S290	46.3091	5.16	No	Yes	0	6	7
37	R:R:C328	R:R:M332	46.5226	3.24	No	Yes	0	6	9
38	R:R:M332	R:R:W470	46.4762	8.14	Yes	Yes	1	9	9
39	R:R:Q506	R:R:W502	10.477	5.48	No	Yes	0	5	7
40	R:R:Q506	R:R:R507	11.6624	5.84	No	Yes	0	5	7
41	R:R:L287	R:R:L499	12.7921	5.54	No	No	0	9	9
42	R:R:H322	R:R:L326	28.8712	11.57	Yes	No	0	9	9
43	R:R:L326	R:R:P366	27.9767	4.93	No	Yes	0	9	9
44	R:R:G362	R:R:P366	29.1436	4.06	No	Yes	2	7	9
45	R:R:G362	R:R:W331	42.4464	7.04	No	Yes	2	7	9
46	R:R:P302	R:R:S301	24.699	3.56	No	No	0	5	6
47	R:R:P302	R:R:T227	26.5715	5.25	No	Yes	0	5	9
48	R:R:I403	R:R:S301	24.699	7.74	No	No	0	4	6
49	R:R:I403	R:R:T227	26.6427	4.56	No	Yes	0	4	9
50	R:R:F304	R:R:L317	24.8073	6.09	No	No	0	5	6
51	R:R:L317	R:R:S301	45.3125	3	No	No	0	6	6
52	R:R:I386	R:R:M401	10.1644	2.92	No	Yes	0	6	2
53	R:R:F304	R:R:V309	12.43	1.31	No	No	0	5	1
54	R:R:H322	R:R:Y381	14.092	10.89	Yes	Yes	3	9	9
55	R:R:G362	R:R:T330	12.6745	3.64	No	No	2	7	6
56	R:R:T330	R:R:Y419	12.1297	11.24	No	No	0	6	9
57	R:R:L329	R:R:Y419	12.8664	3.52	No	No	0	8	9
58	R:R:M332	R:R:N427	14.7451	4.21	Yes	No	0	9	9
59	R:R:L339	R:R:L462	11.4086	6.92	No	No	9	8	8
60	R:R:L462	R:R:L466	13.0861	4.15	No	No	0	8	9
61	R:R:L466	R:R:N427	13.9187	5.49	No	No	0	9	9
62	R:R:L339	R:R:L343	10.6441	2.77	No	No	0	8	6
63	R:R:G420	R:R:L329	10.2108	1.71	No	No	0	7	8
64	R:R:L299	R:R:L300	12.43	1.38	No	No	0	7	4
65	R:R:L300	R:R:L317	16.5619	1.38	No	No	0	4	6
66	R:R:L287	R:R:S290	11.7676	4.5	No	Yes	0	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7EQ1_nogp

PDB Summary
PDB	7EQ1_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	261
Number of Links	288
Number of Hubs	36
Number of Links mediated by Hubs	135
Number of Communities	9
Number of Nodes involved in Communities	42
Number of Links involved in Communities	53

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	54596
Length Of Smallest Path	3
Average Path Length	16.2105
Length of Longest Path	35
Minimum Path Strength	0.97
Average Path Strength	5.76188
Maximum Path Strength	16.37
Minimum Path Correlation	0.7
Average Path Correlation	0.939168
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	54.399
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.9021
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• peptide hormone receptor binding • protein binding • binding • corticotropin-releasing hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • insulin-like growth factor receptor binding • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of biological process • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • positive regulation of cellular process • cell division • response to ketone • response to lipid • response to alcohol • cellular response to forskolin • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • intracellular anatomical structure • cytoplasm • midbody • cell cortex • intracellular organelle • centrosome • microtubule organizing center • cytoskeleton • organelle • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • membrane-bounded organelle • nucleus • intracellular membrane-bounded organelle • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell surface receptor signaling pathway • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8IZF4
Sequence	>7EQ1_nogp_Chain_R T Y F A V L M Q L S P A L V P A E L L A P L T Y I S L V G C S I S I V A S L I T V L L H F H F R K Q S D S L T R I H M N L H A S V L L L N I A F L L S P A F A M S P V P G S A C T A L A A A L H Y A L L S C L T W M A I E G F N L Y L L L G R V Y N I Y I R R Y V F K L G V L G W G A P A L L V L L S L S V K S S V Y G P C T I P V F D S W E N G T G F Q N M S I C W V R S P V V H S V L V M G Y G G L T S L F N L V V L A W A L W T L R R L R E H D T V T V L G L T V L L G T T W A L A F F S F G V F L L P Q L F L F T I L N S L Y G F F L F L W F C S Q R C R S E A E A K A Q I E A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7EQ1	B2	Adhesion	Adhesion	ADGRG5	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.3	2022-05-11	10.1038/s41586-022-04619-y
	7EQ1 (No Gprot)	B2	Adhesion	Adhesion	ADGRG5	Homo sapiens	-	-		3.3	2022-05-11	10.1038/s41586-022-04619-y

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7EQ1_nogp.zip

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