psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L176	R:R:V14	10.43	No	No	0	3	4
2	R:R:I15	R:R:P105	11.85	No	No	0	7	2
3	R:R:H18	R:R:L17	11.57	Yes	No	0	8	3
4	R:R:L17	R:R:L179	13.84	No	No	0	3	2
5	R:R:C175	R:R:H18	4.42	No	Yes	4	6	8
6	R:R:C182	R:R:H18	14.74	No	Yes	4	9	8
7	R:R:H18	R:R:P187	3.05	Yes	No	0	8	4
8	R:R:L25	R:R:Y19	3.52	No	Yes	1	6	9
9	R:R:L101	R:R:Y19	3.52	No	Yes	1	6	9
10	R:R:W108	R:R:Y19	3.86	Yes	Yes	1	9	9
11	R:R:P187	R:R:Y19	25.03	No	Yes	0	4	9
12	R:R:L179	R:R:Y21	3.52	No	No	0	2	5
13	R:R:D180	R:R:Y21	11.49	No	No	0	3	5
14	R:R:A279	R:R:Y21	6.67	No	No	0	2	5
15	R:R:G23	R:R:T22	3.64	No	No	0	7	8
16	R:R:K24	R:R:T22	3	No	No	0	6	8
17	R:R:G23	R:R:R26	7.51	No	No	0	7	3
18	L:L:?1	R:R:K24	4.67	Yes	No	0	0	6
19	R:R:L101	R:R:L25	8.3	No	No	1	6	6
20	R:R:A38	R:R:R37	2.77	No	No	0	7	3
21	R:R:R37	R:R:V41	3.92	No	No	0	3	5
22	R:R:D39	R:R:Q287	6.53	No	Yes	5	3	4
23	R:R:D289	R:R:D39	3.99	No	No	5	4	3
24	R:R:C43	R:R:Y89	8.06	No	Yes	0	6	7
25	R:R:I93	R:R:L44	4.28	Yes	No	0	6	4
26	R:R:I50	R:R:V46	3.07	Yes	No	0	7	6
27	R:R:A90	R:R:C47	3.61	No	No	0	7	6
28	R:R:I50	R:R:N54	4.25	Yes	Yes	0	7	9
29	R:R:I50	R:R:L300	8.56	Yes	No	0	7	6
30	R:R:L83	R:R:V51	2.98	No	No	0	7	6
31	R:R:E53	R:R:V57	7.13	No	No	2	8	9
32	R:R:E53	R:R:P303	3.14	No	Yes	2	8	9
33	R:R:D82	R:R:N54	10.77	No	Yes	2	9	9
34	R:R:L83	R:R:N54	5.49	No	Yes	0	7	9
35	R:R:N54	R:R:P303	3.26	Yes	Yes	2	9	9
36	R:R:P303	R:R:V57	5.3	Yes	No	2	9	9
37	R:R:L58	R:R:T79	2.95	No	No	0	7	9
38	R:R:L58	R:R:L80	2.77	No	No	0	7	5
39	R:R:G62	R:R:L61	3.42	No	Yes	0	3	7
40	R:R:F72	R:R:L61	9.74	No	Yes	0	8	7
41	R:R:G76	R:R:L61	3.42	No	Yes	0	6	7
42	R:R:E132	R:R:P70	3.14	No	Yes	6	9	5
43	R:R:P70	R:R:S147	10.69	Yes	No	6	5	6
44	R:R:P70	R:R:T151	5.25	Yes	Yes	0	5	6
45	R:R:M71	R:R:T309	7.53	No	No	0	8	7
46	R:R:I129	R:R:L74	5.71	Yes	No	0	9	8
47	R:R:L74	R:R:T151	2.95	No	Yes	0	8	6
48	R:R:L75	R:R:T79	2.95	No	No	0	8	9
49	R:R:L78	R:R:S125	7.51	Yes	No	0	9	8
50	R:R:L126	R:R:L78	2.77	Yes	Yes	2	8	9
51	R:R:I129	R:R:L78	2.85	Yes	Yes	2	9	9
52	R:R:L78	R:R:N302	2.75	Yes	Yes	2	9	9
53	R:R:A121	R:R:S81	3.42	No	No	7	7	8
54	R:R:S81	R:R:W159	3.71	No	No	7	8	9
55	R:R:D82	R:R:S299	8.83	No	No	0	9	9
56	R:R:D82	R:R:P303	3.22	No	Yes	2	9	9
57	R:R:A88	R:R:V115	3.39	No	No	0	5	5
58	R:R:I93	R:R:Y89	10.88	Yes	Yes	0	6	7
59	R:R:L292	R:R:Y89	15.24	No	Yes	0	5	7
60	R:R:N92	R:R:R111	3.62	No	Yes	0	5	5
61	L:L:?1	R:R:N92	11.82	Yes	No	0	0	5
62	R:R:L95	R:R:T100	2.95	No	No	1	4	5
63	R:R:L95	R:R:R111	14.58	No	Yes	1	4	5
64	R:R:G97	R:R:P98	4.06	No	No	0	6	3
65	R:R:L103	R:R:T100	5.9	No	No	0	5	5
66	R:R:R111	R:R:T100	6.47	Yes	No	1	5	5
67	R:R:L103	R:R:L107	5.54	No	No	0	5	4
68	R:R:P105	R:R:S104	3.56	No	No	0	2	7
69	R:R:F109	R:R:W108	3.01	Yes	Yes	1	5	9
70	R:R:R111	R:R:W108	8	Yes	Yes	1	5	9
71	R:R:E112	R:R:W108	3.27	Yes	Yes	1	5	9
72	R:R:L186	R:R:W108	4.56	No	Yes	1	7	9
73	R:R:L188	R:R:W108	6.83	No	Yes	1	4	9
74	R:R:W108	R:R:Y189	5.79	Yes	Yes	1	9	5
75	R:R:F109	R:R:P169	4.33	Yes	No	1	5	6
76	R:R:A170	R:R:F109	2.77	No	Yes	0	5	5
77	R:R:F109	R:R:L188	8.53	Yes	No	1	5	4
78	R:R:E112	R:R:L186	5.3	Yes	No	1	5	7
79	R:R:E112	R:R:Y189	12.35	Yes	Yes	1	5	5
80	L:L:?1	R:R:E112	9.65	Yes	Yes	0	0	5
81	R:R:F116	R:R:Y189	4.13	Yes	Yes	1	5	5
82	R:R:F116	R:R:Y193	9.28	Yes	Yes	1	5	7
83	L:L:?1	R:R:F116	7.26	Yes	Yes	0	0	5
84	R:R:S162	R:R:V117	3.23	No	No	0	7	5
85	R:R:L163	R:R:V117	2.98	No	No	0	5	5
86	R:R:L119	R:R:W264	6.83	No	No	0	7	9
87	L:L:?1	R:R:L119	7.33	Yes	No	0	0	7
88	R:R:S162	R:R:T120	3.2	No	No	0	7	6
89	L:L:?1	R:R:T120	10.74	Yes	No	0	0	6
90	R:R:A121	R:R:W159	3.89	No	No	7	7	9
91	R:R:A121	R:R:S162	3.42	No	No	0	7	7
92	R:R:I204	R:R:V123	3.07	No	No	0	8	8
93	L:L:?1	R:R:V123	7.89	Yes	No	0	0	8
94	R:R:A158	R:R:L124	3.15	No	No	0	7	5
95	R:R:L126	R:R:N298	2.75	Yes	Yes	2	8	9
96	R:R:L126	R:R:N302	2.75	Yes	Yes	2	8	9
97	R:R:L126	R:R:Y306	3.52	Yes	Yes	2	8	9
98	R:R:I204	R:R:L127	7.14	No	No	0	8	7
99	R:R:I208	R:R:L127	5.71	No	No	0	8	7
100	R:R:I129	R:R:R133	3.76	Yes	No	2	9	9
101	R:R:I129	R:R:Y306	3.63	Yes	Yes	2	9	9
102	R:R:A130	R:R:Y212	5.34	No	Yes	0	8	9
103	R:R:E132	R:R:S147	4.31	No	No	6	9	6
104	R:R:R133	R:R:Y212	5.14	No	Yes	0	9	9
105	R:R:R133	R:R:Y306	6.17	No	Yes	2	9	9
106	R:R:R214	R:R:S134	6.59	No	No	0	6	8
107	R:R:R139	R:R:T136	7.76	No	No	0	5	8
108	R:R:I215	R:R:M137	5.83	No	No	0	9	8
109	R:R:P144	R:R:R139	17.29	No	No	0	4	5
110	R:R:G141	R:R:P142	4.06	No	No	0	6	3
111	R:R:L152	R:R:T151	2.95	No	Yes	0	1	6
112	R:R:M154	R:R:T151	3.01	No	Yes	0	5	6
113	R:R:L168	R:R:Y193	7.03	No	Yes	0	5	7
114	R:R:P169	R:R:Y189	5.56	No	Yes	1	6	5
115	R:R:P169	R:R:Y193	12.52	No	Yes	1	6	7
116	R:R:A192	R:R:W173	3.89	No	No	0	4	4
117	R:R:W173	R:R:Y193	6.75	No	Yes	0	4	7
118	R:R:L188	R:R:N174	5.49	No	No	0	4	6
119	R:R:A181	R:R:C175	3.61	No	No	0	4	6
120	R:R:C175	R:R:C182	5.46	No	No	4	6	9
121	R:R:K191	R:R:S183	9.18	No	No	0	4	5
122	R:R:T184	R:R:V185	3.17	No	No	3	5	4
123	R:R:D274	R:R:T184	5.78	No	No	3	4	5
124	R:R:D274	R:R:V185	2.92	No	No	3	4	4
125	R:R:L285	R:R:V185	2.98	Yes	No	3	1	4
126	R:R:L186	R:R:Y189	8.21	No	Yes	1	7	5
127	R:R:Y189	R:R:Y193	5.96	Yes	Yes	1	5	7
128	L:L:?1	R:R:C197	11.56	Yes	No	0	0	5
129	R:R:F268	R:R:V198	3.93	Yes	No	0	7	4
130	R:R:F201	R:R:F268	9.65	No	Yes	0	8	7
131	L:L:?1	R:R:F201	4.84	Yes	No	0	0	8
132	R:R:F268	R:R:V202	3.93	Yes	No	0	7	4
133	R:R:L253	R:R:Y212	8.21	No	Yes	0	8	9
134	R:R:L257	R:R:Y212	4.69	No	Yes	0	8	9
135	R:R:R220	R:R:Y216	12.35	No	No	0	5	6
136	R:R:L249	R:R:Y216	4.69	No	No	0	8	6
137	R:R:L250	R:R:Y216	14.07	No	No	0	7	6
138	R:R:N222	R:R:Q218	3.96	No	No	0	7	5
139	R:R:K243	R:R:P244	3.35	No	No	0	4	4
140	R:R:L249	R:R:L253	2.77	No	No	0	8	8
141	R:R:L250	R:R:S254	3	No	No	0	7	6
142	R:R:I305	R:R:V256	3.07	No	No	0	9	8
143	R:R:F260	R:R:W264	7.02	No	No	2	9	9
144	R:R:F260	R:R:N298	12.08	No	Yes	2	9	9
145	R:R:A297	R:R:C263	3.61	No	No	0	5	8
146	R:R:C263	R:R:N298	6.3	No	Yes	0	8	9
147	R:R:N298	R:R:W264	18.08	Yes	No	2	9	9
148	R:R:G265	R:R:P266	4.06	No	No	0	5	9
149	R:R:F291	R:R:P266	2.89	No	No	0	5	9
150	R:R:L267	R:R:L271	5.54	No	No	0	7	6
151	L:L:?1	R:R:L267	6.42	Yes	No	0	0	7
152	R:R:F268	R:R:L272	6.09	Yes	No	0	7	5
153	R:R:L269	R:R:L272	2.77	No	No	0	5	5
154	R:R:L270	R:R:L271	2.77	No	No	0	5	6
155	R:R:L270	R:R:L273	4.15	No	No	0	5	5
156	R:R:F291	R:R:L270	14.61	No	No	0	5	5
157	R:R:C282	R:R:L273	3.17	Yes	No	0	4	5
158	R:R:D274	R:R:L285	4.07	No	Yes	3	4	1
159	R:R:C277	R:R:C282	7.28	No	Yes	3	5	4
160	R:R:C277	R:R:L285	4.76	No	Yes	3	5	1
161	R:R:C282	R:R:L285	4.76	Yes	Yes	3	4	1
162	R:R:D289	R:R:Q287	5.22	No	Yes	5	4	4
163	R:R:P290	R:R:Q287	7.9	No	Yes	0	4	4
164	R:R:L292	R:R:M296	2.83	No	No	0	5	7
165	L:L:?1	R:R:L292	7.33	Yes	No	0	0	5
166	R:R:M296	R:R:S299	7.67	No	No	0	7	9
167	R:R:A297	R:R:L300	3.15	No	No	0	5	6
168	R:R:N298	R:R:N302	5.45	Yes	Yes	2	9	9
169	R:R:L300	R:R:L301	2.77	No	No	0	6	6
170	R:R:I304	R:R:L301	2.85	No	No	0	6	6
171	R:R:N302	R:R:P303	3.26	Yes	Yes	2	9	9
172	R:R:I305	R:R:Y306	4.84	No	Yes	0	9	9
173	R:R:L286	R:R:Q287	2.66	No	Yes	0	1	4
174	R:R:R150	R:R:S146	2.64	No	No	0	7	5
175	R:R:A190	R:R:W173	2.59	No	No	0	5	4
176	R:R:F49	R:R:I50	2.51	No	Yes	0	4	7
177	R:R:L135	R:R:R150	2.43	No	No	0	4	7
178	R:R:L152	R:R:R148	2.43	No	No	0	1	7
179	R:R:L285	R:R:R280	2.43	Yes	No	0	1	3
180	R:R:L286	R:R:R280	2.43	No	No	0	1	3
181	R:R:L84	R:R:W159	2.28	No	No	0	7	9
182	R:R:G113	R:R:G114	2.11	No	No	0	6	5
183	L:L:?1	R:R:A288	2.09	Yes	No	0	0	4
184	R:R:G141	R:R:P144	2.03	No	No	0	6	4
185	R:R:C43	R:R:G293	1.96	No	No	0	6	5
186	R:R:A85	R:R:G86	1.95	No	No	0	8	7
187	R:R:A206	R:R:G203	1.95	No	No	0	3	4
188	R:R:C277	R:R:P278	1.88	No	No	0	5	3
189	R:R:C282	R:R:P283	1.88	Yes	No	0	4	4
190	R:R:A69	R:R:P70	1.87	No	Yes	0	7	5
191	R:R:A143	R:R:P144	1.87	No	No	0	8	4
192	R:R:G86	R:R:V51	1.84	No	No	0	7	6
193	R:R:G114	R:R:V117	1.84	No	No	0	5	5
194	R:R:G203	R:R:V202	1.84	No	No	0	4	4
195	R:R:A118	R:R:A85	1.79	No	No	0	7	8
196	R:R:P278	R:R:T281	1.75	No	No	0	3	4
197	R:R:G97	R:R:L101	1.71	No	No	0	6	6
198	R:R:A106	R:R:S104	1.71	No	No	0	1	7
199	R:R:G160	R:R:L163	1.71	No	No	0	4	5
200	R:R:G172	R:R:N174	1.7	No	No	0	5	6
201	R:R:K191	R:R:P278	1.67	No	No	0	4	3
202	R:R:L99	R:R:P98	1.64	No	No	0	4	3
203	R:R:L294	R:R:P266	1.64	No	No	0	7	9
204	R:R:S125	R:R:S77	1.63	No	No	0	8	9
205	R:R:S122	R:R:S81	1.63	No	No	0	9	8
206	R:R:A40	R:R:I93	1.62	No	Yes	0	4	6
207	R:R:S183	R:R:V194	1.62	No	No	0	5	6
208	R:R:S246	R:R:V219	1.62	No	Yes	0	7	8
209	R:R:A128	R:R:M154	1.61	No	No	0	6	5
210	R:R:V194	R:R:V275	1.6	No	No	0	6	4
211	R:R:T79	R:R:V57	1.59	No	No	0	9	9
212	R:R:A207	R:R:L127	1.58	No	No	0	5	7
213	R:R:A259	R:R:L301	1.58	No	No	0	7	6
214	R:R:A295	R:R:L267	1.58	No	No	0	7	7
215	R:R:I93	R:R:S96	1.55	Yes	No	0	6	5
216	R:R:M137	R:R:V219	1.52	No	Yes	0	8	8
217	R:R:F116	R:R:G166	1.51	Yes	No	0	5	8
218	R:R:G62	R:R:R63	1.5	No	No	0	3	5
219	R:R:L211	R:R:S134	1.5	No	No	0	7	8
220	R:R:G149	R:R:R148	1.5	No	No	0	3	7
221	R:R:L17	R:R:V14	1.49	No	No	0	3	4
222	R:R:L52	R:R:V51	1.49	No	No	0	4	6
223	R:R:L165	R:R:V161	1.49	Yes	No	0	6	4
224	R:R:L205	R:R:V261	1.49	No	No	0	6	6
225	R:R:L249	R:R:V219	1.49	No	Yes	0	8	8
226	R:R:L273	R:R:V284	1.49	No	No	0	5	4
227	R:R:L124	R:R:T120	1.47	No	No	0	5	6
228	R:R:N310	R:R:T309	1.46	No	No	0	8	7
229	R:R:P244	R:R:R242	1.44	No	No	0	4	4
230	R:R:Q218	R:R:V219	1.43	No	Yes	0	5	8
231	R:R:L55	R:R:L83	1.38	No	No	0	4	7
232	R:R:L61	R:R:L75	1.38	Yes	No	0	7	8
233	R:R:L131	R:R:L211	1.38	No	No	0	6	7
234	R:R:A138	R:R:R214	1.38	No	No	0	6	6
235	R:R:L164	R:R:L165	1.38	No	Yes	0	3	6
236	R:R:L168	R:R:L171	1.38	No	No	0	5	5
237	R:R:A181	R:R:R178	1.38	No	No	0	4	3
238	R:R:L226	R:R:N222	1.37	No	No	0	6	7
239	R:R:C47	R:R:Y89	1.34	No	Yes	0	6	7
240	R:R:R139	R:R:V145	1.31	No	No	0	5	4
241	R:R:F260	R:R:V261	1.31	No	No	0	9	6
242	R:R:R251	R:R:T252	1.29	No	No	0	7	9
243	R:R:M154	R:R:R150	1.24	No	No	0	5	7
244	R:R:F196	R:R:L165	1.22	No	Yes	0	5	6
245	R:R:L165	R:R:Y193	1.17	Yes	Yes	0	6	7
246	R:R:F72	R:R:H68	1.13	No	No	0	8	8
247	R:R:H68	R:R:R148	1.13	No	No	0	8	7
248	L:L:?1	R:R:V115	0.99	Yes	No	0	0	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:H18	8.445	4	4	8
2	R:R:Y19	8.9825	4	1	9
3	R:R:I50	4.5975	4	0	7
4	R:R:N54	5.9425	4	2	9
5	R:R:L61	4.49	4	0	7
6	R:R:P70	5.2375	4	6	5
7	R:R:L78	3.97	4	2	9
8	R:R:Y89	8.88	4	0	7
9	R:R:I93	4.5825	4	0	6
10	R:R:W108	5.04571	7	1	9
11	R:R:F109	4.66	4	1	5
12	R:R:R111	8.1675	4	1	5
13	R:R:E112	7.6425	4	1	5
14	R:R:F116	5.545	4	1	5
15	R:R:L126	2.9475	4	2	8
16	R:R:I129	3.9875	4	2	9
17	R:R:T151	3.54	4	0	6
18	R:R:L165	1.315	4	0	6
19	R:R:Y189	7	6	1	5
20	R:R:Y193	7.11833	6	1	7
21	R:R:Y212	5.845	4	0	9
22	R:R:V219	1.515	4	0	8
23	R:R:F268	5.9	4	0	7
24	R:R:C282	4.2725	4	3	4
25	R:R:L285	3.8	5	3	1
26	R:R:Q287	5.5775	4	5	4
27	R:R:N298	8.932	5	2	9
28	R:R:N302	3.5525	4	2	9
29	R:R:P303	3.636	5	2	9
30	R:R:Y306	4.54	4	2	9
31	L:L:?1	7.12231	13	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H18	R:R:L17	13.846	11.57	Yes	No	0	8	3
2	R:R:H18	R:R:P187	23.0794	3.05	Yes	No	0	8	4
3	R:R:P187	R:R:Y19	24.9132	25.03	No	Yes	0	4	9
4	R:R:W108	R:R:Y19	35.5037	3.86	Yes	Yes	1	9	9
5	L:L:?1	R:R:E112	46.9505	9.65	Yes	Yes	0	0	5
6	R:R:E112	R:R:W108	40.8434	3.27	Yes	Yes	1	5	9
7	R:R:L285	R:R:R280	11.6568	2.43	Yes	No	0	1	3
8	R:R:C282	R:R:L285	20.6075	4.76	Yes	Yes	3	4	1
9	R:R:C282	R:R:L273	37.4424	3.17	Yes	No	0	4	5
10	R:R:L270	R:R:L273	40.8676	4.15	No	No	0	5	5
11	R:R:L270	R:R:L271	49.1478	2.77	No	No	0	5	6
12	R:R:L267	R:R:L271	50.7553	5.54	No	No	0	7	6
13	L:L:?1	R:R:L267	53.922	6.42	Yes	No	0	0	7
14	R:R:L292	R:R:Y89	18.1679	15.24	No	Yes	0	5	7
15	L:L:?1	R:R:L292	41.2877	7.33	Yes	No	0	0	5
16	R:R:D82	R:R:N54	11.8992	10.77	No	Yes	2	9	9
17	R:R:D82	R:R:S299	28.9684	8.83	No	No	0	9	9
18	R:R:M296	R:R:S299	29.2431	7.67	No	No	0	7	9
19	R:R:L292	R:R:M296	29.5743	2.83	No	No	0	5	7
20	L:L:?1	R:R:L119	100	7.33	Yes	No	0	0	7
21	R:R:L119	R:R:W264	99.8869	6.83	No	No	0	7	9
22	R:R:N298	R:R:W264	96.6476	18.08	Yes	No	2	9	9
23	R:R:C263	R:R:N298	10.1058	6.3	No	Yes	0	8	9
24	R:R:L83	R:R:N54	12.3193	5.49	No	Yes	0	7	9
25	R:R:D82	R:R:P303	16.7865	3.22	No	Yes	2	9	9
26	R:R:N302	R:R:P303	26.7792	3.26	Yes	Yes	2	9	9
27	R:R:N298	R:R:N302	35.7056	5.45	Yes	Yes	2	9	9
28	R:R:P303	R:R:V57	27.999	5.3	Yes	No	2	9	9
29	R:R:T79	R:R:V57	25.5675	1.59	No	No	0	9	9
30	R:R:L61	R:R:L75	15.7202	1.38	Yes	No	0	7	8
31	R:R:L75	R:R:T79	18.1517	2.95	No	No	0	8	9
32	R:R:P70	R:R:T151	15.9625	5.25	Yes	Yes	0	5	6
33	R:R:L74	R:R:T151	53.5504	2.95	No	Yes	0	8	6
34	R:R:I129	R:R:L74	57.234	5.71	Yes	No	0	9	8
35	R:R:I129	R:R:L78	43.8565	2.85	Yes	Yes	2	9	9
36	R:R:L126	R:R:L78	21.181	2.77	Yes	Yes	2	8	9
37	R:R:L126	R:R:N298	61.0712	2.75	Yes	Yes	2	8	9
38	R:R:I129	R:R:Y306	18.1679	3.63	Yes	Yes	2	9	9
39	R:R:L126	R:R:Y306	43.4849	3.52	Yes	Yes	2	8	9
40	R:R:L78	R:R:N302	29.6066	2.75	Yes	Yes	2	9	9
41	R:R:A121	R:R:S162	10.0493	3.42	No	No	0	7	7
42	R:R:S162	R:R:T120	21.5849	3.2	No	No	0	7	6
43	L:L:?1	R:R:T120	27.1347	10.74	Yes	No	0	0	6
44	R:R:S162	R:R:V117	10.0493	3.23	No	No	0	7	5
45	L:L:?1	R:R:V123	10.0493	7.89	Yes	No	0	0	8
46	R:R:R133	R:R:Y306	22.2635	6.17	No	Yes	2	9	9
47	R:R:R133	R:R:Y212	27.5063	5.14	No	Yes	0	9	9
48	R:R:L249	R:R:V219	12.6666	1.49	No	Yes	0	8	8
49	R:R:L249	R:R:L253	21.2376	2.77	No	No	0	8	8
50	R:R:L253	R:R:Y212	22.7886	8.21	No	Yes	0	8	9
51	R:R:L152	R:R:T151	16.4634	2.95	No	Yes	0	1	6
52	R:R:M154	R:R:T151	19.5735	3.01	No	Yes	0	5	6
53	R:R:C277	R:R:P278	12.0123	1.88	No	No	0	5	3
54	R:R:C277	R:R:C282	13.3371	7.28	No	Yes	3	5	4
55	R:R:F201	R:R:F268	13.9591	9.65	No	Yes	0	8	7
56	L:L:?1	R:R:F201	15.8898	4.84	Yes	No	0	0	8
57	R:R:M154	R:R:R150	11.6488	1.24	No	No	0	5	7
58	R:R:L152	R:R:R148	12.6666	2.43	No	No	0	1	7
59	L:L:?1	R:R:F116	24.6547	7.26	Yes	Yes	0	0	5
60	R:R:F116	R:R:Y193	18.2648	9.28	Yes	Yes	1	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K24	R:R:T22	3	0	No	No	6	8	1	2
L:L:?1	R:R:K24	4.67	0	Yes	No	0	6	0	1
R:R:A88	R:R:V115	3.39	0	No	No	5	5	2	1
R:R:L292	R:R:Y89	15.24	0	No	Yes	5	7	1	2
R:R:N92	R:R:R111	3.62	0	No	Yes	5	5	1	2
L:L:?1	R:R:N92	11.82	0	Yes	No	0	5	0	1
R:R:R111	R:R:W108	8	1	Yes	Yes	5	9	2	2
R:R:E112	R:R:W108	3.27	1	Yes	Yes	5	9	1	2
R:R:L186	R:R:W108	4.56	1	No	Yes	7	9	2	2
R:R:W108	R:R:Y189	5.79	1	Yes	Yes	9	5	2	2
R:R:E112	R:R:L186	5.3	1	Yes	No	5	7	1	2
R:R:E112	R:R:Y189	12.35	1	Yes	Yes	5	5	1	2
L:L:?1	R:R:E112	9.65	0	Yes	Yes	0	5	0	1
R:R:F116	R:R:Y189	4.13	1	Yes	Yes	5	5	1	2
R:R:F116	R:R:Y193	9.28	1	Yes	Yes	5	7	1	2
L:L:?1	R:R:F116	7.26	0	Yes	Yes	0	5	0	1
R:R:L119	R:R:W264	6.83	0	No	No	7	9	1	2
L:L:?1	R:R:L119	7.33	0	Yes	No	0	7	0	1
R:R:S162	R:R:T120	3.2	0	No	No	7	6	2	1
L:L:?1	R:R:T120	10.74	0	Yes	No	0	6	0	1
R:R:I204	R:R:V123	3.07	0	No	No	8	8	2	1
L:L:?1	R:R:V123	7.89	0	Yes	No	0	8	0	1
R:R:L186	R:R:Y189	8.21	1	No	Yes	7	5	2	2
R:R:Y189	R:R:Y193	5.96	1	Yes	Yes	5	7	2	2
L:L:?1	R:R:C197	11.56	0	Yes	No	0	5	0	1
R:R:F201	R:R:F268	9.65	0	No	Yes	8	7	1	2
L:L:?1	R:R:F201	4.84	0	Yes	No	0	8	0	1
R:R:L267	R:R:L271	5.54	0	No	No	7	6	1	2
L:L:?1	R:R:L267	6.42	0	Yes	No	0	7	0	1
R:R:L292	R:R:M296	2.83	0	No	No	5	7	1	2
L:L:?1	R:R:L292	7.33	0	Yes	No	0	5	0	1
L:L:?1	R:R:A288	2.09	0	Yes	No	0	4	0	1
R:R:A295	R:R:L267	1.58	0	No	No	7	7	2	1
R:R:F116	R:R:G166	1.51	1	Yes	No	5	8	1	2
R:R:L124	R:R:T120	1.47	0	No	No	5	6	2	1
L:L:?1	R:R:V115	0.99	0	Yes	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EW1_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.75
Number of Linked Nodes	228
Number of Links	248
Number of Hubs	31
Number of Links mediated by Hubs	117
Number of Communities	7
Number of Nodes involved in Communities	47
Number of Links involved in Communities	63

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	27693
Length Of Smallest Path	3
Average Path Length	11.5815
Length of Longest Path	25
Minimum Path Strength	1.13
Average Path Strength	5.7908
Maximum Path Strength	14.445
Minimum Path Correlation	0.7
Average Path Correlation	0.923706
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	54.4397
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.1871
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • bioactive lipid receptor activity • sphingosine-1-phosphate receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • developmental process • multicellular organismal process • regulation of developmental process • cellular developmental process • regulation of cell differentiation • nervous system development • generation of neurons • neurogenesis • multicellular organism development • neuron differentiation • cell differentiation • anatomical structure development • regulation of neuron differentiation • system development • presynapse
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	J8C
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	J8C
Name	Siponimod
Synonyms	Siponimod fumarate Siponimod
Identifier
Formula	C29 H35 F3 N2 O3
Molecular Weight	516.595
SMILES
PubChem	72959169
Formal Charge	0
Total Atoms	72
Total Chiral Atoms	0
Total Bonds	75
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9H228
Sequence	>7EW1_nogp_Chain_R V I V L H Y N Y T G K L R G R A D A V V C L A V C A F I V L E N L A V L L V L G R H A P M F L L L G S L T L S D L L A G A A Y A A N I L L S G P L T L K L S P A L W F A R E G G V F V A L T A S V L S L L A I A L E R S L T M A R R G P A P V S S R G R T L A M A A A A W G V S L L L G L L P A L G W N C L G R L D A C S T V L P L Y A K A Y V L F C V L A F V G I L A A I C A L Y A R I Y C Q V R A N A R R L R K P R S L A L L R T L S V V L L A F V A C W G P L F L L L L L D V A C P A R T C P V L L Q A D P F L G L A M A N S L L N P I I Y T L T N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7YXA	A	Lipid	Lysophospholipid	S1P₅	Homo sapiens	ONO-5430608	-	-	2.2	2022-08-10	10.1038/s41467-022-32447-1
	7EW1	A	Lipid	Lysophospholipid	S1P₅	Homo sapiens	Siponimod	-	Gi1/β1/γ2	3.4	2021-09-29	10.1038/s41422-021-00566-x
	7EW1 (No Gprot)	A	Lipid	Lysophospholipid	S1P₅	Homo sapiens	Siponimod	-		3.4	2021-09-29	10.1038/s41422-021-00566-x

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7EW1_nogp.zip

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