psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L176	R:R:V14	10.43	No	No	0	3	4
2	R:R:I15	R:R:P105	11.85	No	No	0	7	2
3	R:R:H18	R:R:L17	11.57	Yes	No	0	8	3
4	R:R:L17	R:R:L179	13.84	No	No	0	3	2
5	R:R:C175	R:R:H18	4.42	No	Yes	4	6	8
6	R:R:C182	R:R:H18	14.74	No	Yes	4	9	8
7	R:R:H18	R:R:P187	3.05	Yes	No	0	8	4
8	R:R:L25	R:R:Y19	3.52	No	Yes	1	6	9
9	R:R:L101	R:R:Y19	3.52	No	Yes	1	6	9
10	R:R:W108	R:R:Y19	3.86	Yes	Yes	1	9	9
11	R:R:P187	R:R:Y19	25.03	No	Yes	0	4	9
12	R:R:L179	R:R:Y21	3.52	No	No	0	2	5
13	R:R:D180	R:R:Y21	11.49	No	No	0	3	5
14	R:R:A279	R:R:Y21	6.67	No	No	0	2	5
15	R:R:G23	R:R:T22	3.64	No	No	0	7	8
16	R:R:K24	R:R:T22	3	No	No	0	6	8
17	R:R:G23	R:R:R26	7.51	No	No	0	7	3
18	L:L:?1	R:R:K24	4.67	Yes	No	0	0	6
19	R:R:L101	R:R:L25	8.3	No	No	1	6	6
20	R:R:A38	R:R:R37	2.77	No	No	0	7	3
21	R:R:R37	R:R:V41	3.92	No	No	0	3	5
22	R:R:D39	R:R:Q287	6.53	No	Yes	5	3	4
23	R:R:D289	R:R:D39	3.99	No	No	5	4	3
24	R:R:C43	R:R:Y89	8.06	No	Yes	0	6	7
25	R:R:I93	R:R:L44	4.28	Yes	No	0	6	4
26	R:R:I50	R:R:V46	3.07	Yes	No	0	7	6
27	R:R:A90	R:R:C47	3.61	No	No	0	7	6
28	R:R:I50	R:R:N54	4.25	Yes	Yes	0	7	9
29	R:R:I50	R:R:L300	8.56	Yes	No	0	7	6
30	R:R:L83	R:R:V51	2.98	No	No	0	7	6
31	R:R:E53	R:R:V57	7.13	No	No	2	8	9
32	R:R:E53	R:R:P303	3.14	No	Yes	2	8	9
33	R:R:D82	R:R:N54	10.77	No	Yes	2	9	9
34	R:R:L83	R:R:N54	5.49	No	Yes	0	7	9
35	R:R:N54	R:R:P303	3.26	Yes	Yes	2	9	9
36	R:R:P303	R:R:V57	5.3	Yes	No	2	9	9
37	R:R:L58	R:R:T79	2.95	No	No	0	7	9
38	R:R:L58	R:R:L80	2.77	No	No	0	7	5
39	R:R:G62	R:R:L61	3.42	No	Yes	0	3	7
40	R:R:F72	R:R:L61	9.74	No	Yes	0	8	7
41	R:R:G76	R:R:L61	3.42	No	Yes	0	6	7
42	R:R:E132	R:R:P70	3.14	No	Yes	6	9	5
43	R:R:P70	R:R:S147	10.69	Yes	No	6	5	6
44	R:R:P70	R:R:T151	5.25	Yes	Yes	0	5	6
45	R:R:M71	R:R:T309	7.53	No	No	0	8	7
46	R:R:I129	R:R:L74	5.71	Yes	No	0	9	8
47	R:R:L74	R:R:T151	2.95	No	Yes	0	8	6
48	R:R:L75	R:R:T79	2.95	No	No	0	8	9
49	R:R:L78	R:R:S125	7.51	Yes	No	0	9	8
50	R:R:L126	R:R:L78	2.77	Yes	Yes	2	8	9
51	R:R:I129	R:R:L78	2.85	Yes	Yes	2	9	9
52	R:R:L78	R:R:N302	2.75	Yes	Yes	2	9	9
53	R:R:A121	R:R:S81	3.42	No	No	7	7	8
54	R:R:S81	R:R:W159	3.71	No	No	7	8	9
55	R:R:D82	R:R:S299	8.83	No	No	0	9	9
56	R:R:D82	R:R:P303	3.22	No	Yes	2	9	9
57	R:R:A88	R:R:V115	3.39	No	No	0	5	5
58	R:R:I93	R:R:Y89	10.88	Yes	Yes	0	6	7
59	R:R:L292	R:R:Y89	15.24	No	Yes	0	5	7
60	R:R:N92	R:R:R111	3.62	No	Yes	0	5	5
61	L:L:?1	R:R:N92	11.82	Yes	No	0	0	5
62	R:R:L95	R:R:T100	2.95	No	No	1	4	5
63	R:R:L95	R:R:R111	14.58	No	Yes	1	4	5
64	R:R:G97	R:R:P98	4.06	No	No	0	6	3
65	R:R:L103	R:R:T100	5.9	No	No	0	5	5
66	R:R:R111	R:R:T100	6.47	Yes	No	1	5	5
67	R:R:L103	R:R:L107	5.54	No	No	0	5	4
68	R:R:P105	R:R:S104	3.56	No	No	0	2	7
69	R:R:F109	R:R:W108	3.01	Yes	Yes	1	5	9
70	R:R:R111	R:R:W108	8	Yes	Yes	1	5	9
71	R:R:E112	R:R:W108	3.27	Yes	Yes	1	5	9
72	R:R:L186	R:R:W108	4.56	No	Yes	1	7	9
73	R:R:L188	R:R:W108	6.83	No	Yes	1	4	9
74	R:R:W108	R:R:Y189	5.79	Yes	Yes	1	9	5
75	R:R:F109	R:R:P169	4.33	Yes	No	1	5	6
76	R:R:A170	R:R:F109	2.77	No	Yes	0	5	5
77	R:R:F109	R:R:L188	8.53	Yes	No	1	5	4
78	R:R:E112	R:R:L186	5.3	Yes	No	1	5	7
79	R:R:E112	R:R:Y189	12.35	Yes	Yes	1	5	5
80	L:L:?1	R:R:E112	9.65	Yes	Yes	0	0	5
81	R:R:F116	R:R:Y189	4.13	Yes	Yes	1	5	5
82	R:R:F116	R:R:Y193	9.28	Yes	Yes	1	5	7
83	L:L:?1	R:R:F116	7.26	Yes	Yes	0	0	5
84	R:R:S162	R:R:V117	3.23	No	No	0	7	5
85	R:R:L163	R:R:V117	2.98	No	No	0	5	5
86	R:R:L119	R:R:W264	6.83	No	No	0	7	9
87	L:L:?1	R:R:L119	7.33	Yes	No	0	0	7
88	R:R:S162	R:R:T120	3.2	No	No	0	7	6
89	L:L:?1	R:R:T120	10.74	Yes	No	0	0	6
90	R:R:A121	R:R:W159	3.89	No	No	7	7	9
91	R:R:A121	R:R:S162	3.42	No	No	0	7	7
92	R:R:I204	R:R:V123	3.07	No	No	0	8	8
93	L:L:?1	R:R:V123	7.89	Yes	No	0	0	8
94	R:R:A158	R:R:L124	3.15	No	No	0	7	5
95	R:R:L126	R:R:N298	2.75	Yes	Yes	2	8	9
96	R:R:L126	R:R:N302	2.75	Yes	Yes	2	8	9
97	R:R:L126	R:R:Y306	3.52	Yes	Yes	2	8	9
98	R:R:I204	R:R:L127	7.14	No	No	0	8	7
99	R:R:I208	R:R:L127	5.71	No	No	0	8	7
100	R:R:I129	R:R:R133	3.76	Yes	No	2	9	9
101	R:R:I129	R:R:Y306	3.63	Yes	Yes	2	9	9
102	R:R:A130	R:R:Y212	5.34	No	Yes	0	8	9
103	R:R:E132	R:R:S147	4.31	No	No	6	9	6
104	R:R:R133	R:R:Y212	5.14	No	Yes	0	9	9
105	R:R:R133	R:R:Y306	6.17	No	Yes	2	9	9
106	R:R:R214	R:R:S134	6.59	No	No	0	6	8
107	R:R:R139	R:R:T136	7.76	No	No	0	5	8
108	R:R:I215	R:R:M137	5.83	No	No	0	9	8
109	R:R:P144	R:R:R139	17.29	No	No	0	4	5
110	R:R:G141	R:R:P142	4.06	No	No	0	6	3
111	R:R:L152	R:R:T151	2.95	No	Yes	0	1	6
112	R:R:M154	R:R:T151	3.01	No	Yes	0	5	6
113	R:R:L168	R:R:Y193	7.03	No	Yes	0	5	7
114	R:R:P169	R:R:Y189	5.56	No	Yes	1	6	5
115	R:R:P169	R:R:Y193	12.52	No	Yes	1	6	7
116	R:R:A192	R:R:W173	3.89	No	No	0	4	4
117	R:R:W173	R:R:Y193	6.75	No	Yes	0	4	7
118	R:R:L188	R:R:N174	5.49	No	No	0	4	6
119	R:R:A181	R:R:C175	3.61	No	No	0	4	6
120	R:R:C175	R:R:C182	5.46	No	No	4	6	9
121	R:R:K191	R:R:S183	9.18	No	No	0	4	5
122	R:R:T184	R:R:V185	3.17	No	No	3	5	4
123	R:R:D274	R:R:T184	5.78	No	No	3	4	5
124	R:R:D274	R:R:V185	2.92	No	No	3	4	4
125	R:R:L285	R:R:V185	2.98	Yes	No	3	1	4
126	R:R:L186	R:R:Y189	8.21	No	Yes	1	7	5
127	R:R:Y189	R:R:Y193	5.96	Yes	Yes	1	5	7
128	L:L:?1	R:R:C197	11.56	Yes	No	0	0	5
129	R:R:F268	R:R:V198	3.93	Yes	No	0	7	4
130	R:R:F201	R:R:F268	9.65	No	Yes	0	8	7
131	L:L:?1	R:R:F201	4.84	Yes	No	0	0	8
132	R:R:F268	R:R:V202	3.93	Yes	No	0	7	4
133	R:R:L253	R:R:Y212	8.21	No	Yes	0	8	9
134	R:R:L257	R:R:Y212	4.69	No	Yes	0	8	9
135	R:R:R220	R:R:Y216	12.35	No	No	0	5	6
136	R:R:L249	R:R:Y216	4.69	No	No	0	8	6
137	R:R:L250	R:R:Y216	14.07	No	No	0	7	6
138	R:R:N222	R:R:Q218	3.96	No	No	0	7	5
139	R:R:K243	R:R:P244	3.35	No	No	0	4	4
140	R:R:L249	R:R:L253	2.77	No	No	0	8	8
141	R:R:L250	R:R:S254	3	No	No	0	7	6
142	R:R:I305	R:R:V256	3.07	No	No	0	9	8
143	R:R:F260	R:R:W264	7.02	No	No	2	9	9
144	R:R:F260	R:R:N298	12.08	No	Yes	2	9	9
145	R:R:A297	R:R:C263	3.61	No	No	0	5	8
146	R:R:C263	R:R:N298	6.3	No	Yes	0	8	9
147	R:R:N298	R:R:W264	18.08	Yes	No	2	9	9
148	R:R:G265	R:R:P266	4.06	No	No	0	5	9
149	R:R:F291	R:R:P266	2.89	No	No	0	5	9
150	R:R:L267	R:R:L271	5.54	No	No	0	7	6
151	L:L:?1	R:R:L267	6.42	Yes	No	0	0	7
152	R:R:F268	R:R:L272	6.09	Yes	No	0	7	5
153	R:R:L269	R:R:L272	2.77	No	No	0	5	5
154	R:R:L270	R:R:L271	2.77	No	No	0	5	6
155	R:R:L270	R:R:L273	4.15	No	No	0	5	5
156	R:R:F291	R:R:L270	14.61	No	No	0	5	5
157	R:R:C282	R:R:L273	3.17	Yes	No	0	4	5
158	R:R:D274	R:R:L285	4.07	No	Yes	3	4	1
159	R:R:C277	R:R:C282	7.28	No	Yes	3	5	4
160	R:R:C277	R:R:L285	4.76	No	Yes	3	5	1
161	R:R:C282	R:R:L285	4.76	Yes	Yes	3	4	1
162	R:R:D289	R:R:Q287	5.22	No	Yes	5	4	4
163	R:R:P290	R:R:Q287	7.9	No	Yes	0	4	4
164	R:R:L292	R:R:M296	2.83	No	No	0	5	7
165	L:L:?1	R:R:L292	7.33	Yes	No	0	0	5
166	R:R:M296	R:R:S299	7.67	No	No	0	7	9
167	R:R:A297	R:R:L300	3.15	No	No	0	5	6
168	R:R:N298	R:R:N302	5.45	Yes	Yes	2	9	9
169	R:R:L300	R:R:L301	2.77	No	No	0	6	6
170	R:R:I304	R:R:L301	2.85	No	No	0	6	6
171	R:R:N302	R:R:P303	3.26	Yes	Yes	2	9	9
172	R:R:I305	R:R:Y306	4.84	No	Yes	0	9	9
173	R:R:L286	R:R:Q287	2.66	No	Yes	0	1	4
174	R:R:R150	R:R:S146	2.64	No	No	0	7	5
175	R:R:A190	R:R:W173	2.59	No	No	0	5	4
176	R:R:F49	R:R:I50	2.51	No	Yes	0	4	7
177	R:R:L135	R:R:R150	2.43	No	No	0	4	7
178	R:R:L152	R:R:R148	2.43	No	No	0	1	7
179	R:R:L285	R:R:R280	2.43	Yes	No	0	1	3
180	R:R:L286	R:R:R280	2.43	No	No	0	1	3
181	R:R:L84	R:R:W159	2.28	No	No	0	7	9
182	R:R:G113	R:R:G114	2.11	No	No	0	6	5
183	L:L:?1	R:R:A288	2.09	Yes	No	0	0	4
184	R:R:G141	R:R:P144	2.03	No	No	0	6	4
185	R:R:C43	R:R:G293	1.96	No	No	0	6	5
186	R:R:A85	R:R:G86	1.95	No	No	0	8	7
187	R:R:A206	R:R:G203	1.95	No	No	0	3	4
188	R:R:C277	R:R:P278	1.88	No	No	0	5	3
189	R:R:C282	R:R:P283	1.88	Yes	No	0	4	4
190	R:R:A69	R:R:P70	1.87	No	Yes	0	7	5
191	R:R:A143	R:R:P144	1.87	No	No	0	8	4
192	R:R:G86	R:R:V51	1.84	No	No	0	7	6
193	R:R:G114	R:R:V117	1.84	No	No	0	5	5
194	R:R:G203	R:R:V202	1.84	No	No	0	4	4
195	R:R:A118	R:R:A85	1.79	No	No	0	7	8
196	R:R:P278	R:R:T281	1.75	No	No	0	3	4
197	R:R:G97	R:R:L101	1.71	No	No	0	6	6
198	R:R:A106	R:R:S104	1.71	No	No	0	1	7
199	R:R:G160	R:R:L163	1.71	No	No	0	4	5
200	R:R:G172	R:R:N174	1.7	No	No	0	5	6
201	R:R:K191	R:R:P278	1.67	No	No	0	4	3
202	R:R:L99	R:R:P98	1.64	No	No	0	4	3
203	R:R:L294	R:R:P266	1.64	No	No	0	7	9
204	R:R:S125	R:R:S77	1.63	No	No	0	8	9
205	R:R:S122	R:R:S81	1.63	No	No	0	9	8
206	R:R:A40	R:R:I93	1.62	No	Yes	0	4	6
207	R:R:S183	R:R:V194	1.62	No	No	0	5	6
208	R:R:S246	R:R:V219	1.62	No	Yes	0	7	8
209	R:R:A128	R:R:M154	1.61	No	No	0	6	5
210	R:R:V194	R:R:V275	1.6	No	No	0	6	4
211	R:R:T79	R:R:V57	1.59	No	No	0	9	9
212	R:R:A207	R:R:L127	1.58	No	No	0	5	7
213	R:R:A259	R:R:L301	1.58	No	No	0	7	6
214	R:R:A295	R:R:L267	1.58	No	No	0	7	7
215	R:R:I93	R:R:S96	1.55	Yes	No	0	6	5
216	R:R:M137	R:R:V219	1.52	No	Yes	0	8	8
217	R:R:F116	R:R:G166	1.51	Yes	No	0	5	8
218	R:R:G62	R:R:R63	1.5	No	No	0	3	5
219	R:R:L211	R:R:S134	1.5	No	No	0	7	8
220	R:R:G149	R:R:R148	1.5	No	No	0	3	7
221	R:R:L17	R:R:V14	1.49	No	No	0	3	4
222	R:R:L52	R:R:V51	1.49	No	No	0	4	6
223	R:R:L165	R:R:V161	1.49	Yes	No	0	6	4
224	R:R:L205	R:R:V261	1.49	No	No	0	6	6
225	R:R:L249	R:R:V219	1.49	No	Yes	0	8	8
226	R:R:L273	R:R:V284	1.49	No	No	0	5	4
227	R:R:L124	R:R:T120	1.47	No	No	0	5	6
228	R:R:N310	R:R:T309	1.46	No	No	0	8	7
229	R:R:P244	R:R:R242	1.44	No	No	0	4	4
230	R:R:Q218	R:R:V219	1.43	No	Yes	0	5	8
231	R:R:L55	R:R:L83	1.38	No	No	0	4	7
232	R:R:L61	R:R:L75	1.38	Yes	No	0	7	8
233	R:R:L131	R:R:L211	1.38	No	No	0	6	7
234	R:R:A138	R:R:R214	1.38	No	No	0	6	6
235	R:R:L164	R:R:L165	1.38	No	Yes	0	3	6
236	R:R:L168	R:R:L171	1.38	No	No	0	5	5
237	R:R:A181	R:R:R178	1.38	No	No	0	4	3
238	R:R:L226	R:R:N222	1.37	No	No	0	6	7
239	R:R:C47	R:R:Y89	1.34	No	Yes	0	6	7
240	R:R:R139	R:R:V145	1.31	No	No	0	5	4
241	R:R:F260	R:R:V261	1.31	No	No	0	9	6
242	R:R:R251	R:R:T252	1.29	No	No	0	7	9
243	R:R:M154	R:R:R150	1.24	No	No	0	5	7
244	R:R:F196	R:R:L165	1.22	No	Yes	0	5	6
245	R:R:L165	R:R:Y193	1.17	Yes	Yes	0	6	7
246	R:R:F72	R:R:H68	1.13	No	No	0	8	8
247	R:R:H68	R:R:R148	1.13	No	No	0	8	7
248	L:L:?1	R:R:V115	0.99	Yes	No	0	0	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:H18	8.445	4	4	8
2	R:R:Y19	8.9825	4	1	9
3	R:R:I50	4.5975	4	0	7
4	R:R:N54	5.9425	4	2	9
5	R:R:L61	4.49	4	0	7
6	R:R:P70	5.2375	4	6	5
7	R:R:L78	3.97	4	2	9
8	R:R:Y89	8.88	4	0	7
9	R:R:I93	4.5825	4	0	6
10	R:R:W108	5.04571	7	1	9
11	R:R:F109	4.66	4	1	5
12	R:R:R111	8.1675	4	1	5
13	R:R:E112	7.6425	4	1	5
14	R:R:F116	5.545	4	1	5
15	R:R:L126	2.9475	4	2	8
16	R:R:I129	3.9875	4	2	9
17	R:R:T151	3.54	4	0	6
18	R:R:L165	1.315	4	0	6
19	R:R:Y189	7	6	1	5
20	R:R:Y193	7.11833	6	1	7
21	R:R:Y212	5.845	4	0	9
22	R:R:V219	1.515	4	0	8
23	R:R:F268	5.9	4	0	7
24	R:R:C282	4.2725	4	3	4
25	R:R:L285	3.8	5	3	1
26	R:R:Q287	5.5775	4	5	4
27	R:R:N298	8.932	5	2	9
28	R:R:N302	3.5525	4	2	9
29	R:R:P303	3.636	5	2	9
30	R:R:Y306	4.54	4	2	9
31	L:L:?1	7.12231	13	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H18	R:R:L17	13.846	11.57	Yes	No	0	8	3
2	R:R:H18	R:R:P187	23.0794	3.05	Yes	No	0	8	4
3	R:R:P187	R:R:Y19	24.9132	25.03	No	Yes	0	4	9
4	R:R:W108	R:R:Y19	35.5037	3.86	Yes	Yes	1	9	9
5	L:L:?1	R:R:E112	46.9505	9.65	Yes	Yes	0	0	5
6	R:R:E112	R:R:W108	40.8434	3.27	Yes	Yes	1	5	9
7	R:R:L285	R:R:R280	11.6568	2.43	Yes	No	0	1	3
8	R:R:C282	R:R:L285	20.6075	4.76	Yes	Yes	3	4	1
9	R:R:C282	R:R:L273	37.4424	3.17	Yes	No	0	4	5
10	R:R:L270	R:R:L273	40.8676	4.15	No	No	0	5	5
11	R:R:L270	R:R:L271	49.1478	2.77	No	No	0	5	6
12	R:R:L267	R:R:L271	50.7553	5.54	No	No	0	7	6
13	L:L:?1	R:R:L267	53.922	6.42	Yes	No	0	0	7
14	R:R:L292	R:R:Y89	18.1679	15.24	No	Yes	0	5	7
15	L:L:?1	R:R:L292	41.2877	7.33	Yes	No	0	0	5
16	R:R:D82	R:R:N54	11.8992	10.77	No	Yes	2	9	9
17	R:R:D82	R:R:S299	28.9684	8.83	No	No	0	9	9
18	R:R:M296	R:R:S299	29.2431	7.67	No	No	0	7	9
19	R:R:L292	R:R:M296	29.5743	2.83	No	No	0	5	7
20	L:L:?1	R:R:L119	100	7.33	Yes	No	0	0	7
21	R:R:L119	R:R:W264	99.8869	6.83	No	No	0	7	9
22	R:R:N298	R:R:W264	96.6476	18.08	Yes	No	2	9	9
23	R:R:C263	R:R:N298	10.1058	6.3	No	Yes	0	8	9
24	R:R:L83	R:R:N54	12.3193	5.49	No	Yes	0	7	9
25	R:R:D82	R:R:P303	16.7865	3.22	No	Yes	2	9	9
26	R:R:N302	R:R:P303	26.7792	3.26	Yes	Yes	2	9	9
27	R:R:N298	R:R:N302	35.7056	5.45	Yes	Yes	2	9	9
28	R:R:P303	R:R:V57	27.999	5.3	Yes	No	2	9	9
29	R:R:T79	R:R:V57	25.5675	1.59	No	No	0	9	9
30	R:R:L61	R:R:L75	15.7202	1.38	Yes	No	0	7	8
31	R:R:L75	R:R:T79	18.1517	2.95	No	No	0	8	9
32	R:R:P70	R:R:T151	15.9625	5.25	Yes	Yes	0	5	6
33	R:R:L74	R:R:T151	53.5504	2.95	No	Yes	0	8	6
34	R:R:I129	R:R:L74	57.234	5.71	Yes	No	0	9	8
35	R:R:I129	R:R:L78	43.8565	2.85	Yes	Yes	2	9	9
36	R:R:L126	R:R:L78	21.181	2.77	Yes	Yes	2	8	9
37	R:R:L126	R:R:N298	61.0712	2.75	Yes	Yes	2	8	9
38	R:R:I129	R:R:Y306	18.1679	3.63	Yes	Yes	2	9	9
39	R:R:L126	R:R:Y306	43.4849	3.52	Yes	Yes	2	8	9
40	R:R:L78	R:R:N302	29.6066	2.75	Yes	Yes	2	9	9
41	R:R:A121	R:R:S162	10.0493	3.42	No	No	0	7	7
42	R:R:S162	R:R:T120	21.5849	3.2	No	No	0	7	6
43	L:L:?1	R:R:T120	27.1347	10.74	Yes	No	0	0	6
44	R:R:S162	R:R:V117	10.0493	3.23	No	No	0	7	5
45	L:L:?1	R:R:V123	10.0493	7.89	Yes	No	0	0	8
46	R:R:R133	R:R:Y306	22.2635	6.17	No	Yes	2	9	9
47	R:R:R133	R:R:Y212	27.5063	5.14	No	Yes	0	9	9
48	R:R:L249	R:R:V219	12.6666	1.49	No	Yes	0	8	8
49	R:R:L249	R:R:L253	21.2376	2.77	No	No	0	8	8
50	R:R:L253	R:R:Y212	22.7886	8.21	No	Yes	0	8	9
51	R:R:L152	R:R:T151	16.4634	2.95	No	Yes	0	1	6
52	R:R:M154	R:R:T151	19.5735	3.01	No	Yes	0	5	6
53	R:R:C277	R:R:P278	12.0123	1.88	No	No	0	5	3
54	R:R:C277	R:R:C282	13.3371	7.28	No	Yes	3	5	4
55	R:R:F201	R:R:F268	13.9591	9.65	No	Yes	0	8	7
56	L:L:?1	R:R:F201	15.8898	4.84	Yes	No	0	0	8
57	R:R:M154	R:R:R150	11.6488	1.24	No	No	0	5	7
58	R:R:L152	R:R:R148	12.6666	2.43	No	No	0	1	7
59	L:L:?1	R:R:F116	24.6547	7.26	Yes	Yes	0	0	5
60	R:R:F116	R:R:Y193	18.2648	9.28	Yes	Yes	1	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K24	R:R:T22	3	0	No	No	6	8	1	2
L:L:?1	R:R:K24	4.67	0	Yes	No	0	6	0	1
R:R:A88	R:R:V115	3.39	0	No	No	5	5	2	1
R:R:L292	R:R:Y89	15.24	0	No	Yes	5	7	1	2
R:R:N92	R:R:R111	3.62	0	No	Yes	5	5	1	2
L:L:?1	R:R:N92	11.82	0	Yes	No	0	5	0	1
R:R:R111	R:R:W108	8	1	Yes	Yes	5	9	2	2
R:R:E112	R:R:W108	3.27	1	Yes	Yes	5	9	1	2
R:R:L186	R:R:W108	4.56	1	No	Yes	7	9	2	2
R:R:W108	R:R:Y189	5.79	1	Yes	Yes	9	5	2	2
R:R:E112	R:R:L186	5.3	1	Yes	No	5	7	1	2
R:R:E112	R:R:Y189	12.35	1	Yes	Yes	5	5	1	2
L:L:?1	R:R:E112	9.65	0	Yes	Yes	0	5	0	1
R:R:F116	R:R:Y189	4.13	1	Yes	Yes	5	5	1	2
R:R:F116	R:R:Y193	9.28	1	Yes	Yes	5	7	1	2
L:L:?1	R:R:F116	7.26	0	Yes	Yes	0	5	0	1
R:R:L119	R:R:W264	6.83	0	No	No	7	9	1	2
L:L:?1	R:R:L119	7.33	0	Yes	No	0	7	0	1
R:R:S162	R:R:T120	3.2	0	No	No	7	6	2	1
L:L:?1	R:R:T120	10.74	0	Yes	No	0	6	0	1
R:R:I204	R:R:V123	3.07	0	No	No	8	8	2	1
L:L:?1	R:R:V123	7.89	0	Yes	No	0	8	0	1
R:R:L186	R:R:Y189	8.21	1	No	Yes	7	5	2	2
R:R:Y189	R:R:Y193	5.96	1	Yes	Yes	5	7	2	2
L:L:?1	R:R:C197	11.56	0	Yes	No	0	5	0	1
R:R:F201	R:R:F268	9.65	0	No	Yes	8	7	1	2
L:L:?1	R:R:F201	4.84	0	Yes	No	0	8	0	1
R:R:L267	R:R:L271	5.54	0	No	No	7	6	1	2
L:L:?1	R:R:L267	6.42	0	Yes	No	0	7	0	1
R:R:L292	R:R:M296	2.83	0	No	No	5	7	1	2
L:L:?1	R:R:L292	7.33	0	Yes	No	0	5	0	1
L:L:?1	R:R:A288	2.09	0	Yes	No	0	4	0	1
R:R:A295	R:R:L267	1.58	0	No	No	7	7	2	1
R:R:F116	R:R:G166	1.51	1	Yes	No	5	8	1	2
R:R:L124	R:R:T120	1.47	0	No	No	5	6	2	1
L:L:?1	R:R:V115	0.99	0	Yes	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EW1_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.75
Number of Linked Nodes	228
Number of Links	248
Number of Hubs	31
Number of Links mediated by Hubs	117
Number of Communities	7
Number of Nodes involved in Communities	47
Number of Links involved in Communities	63

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	27693
Length Of Smallest Path	3
Average Path Length	11.5815
Length of Longest Path	25
Minimum Path Strength	1.13
Average Path Strength	5.7908
Maximum Path Strength	14.445
Minimum Path Correlation	0.7
Average Path Correlation	0.923707
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	54.4434
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.1871
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	J8C
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	J8C
Name	Siponimod
Synonyms	Siponimod fumarate Siponimod
Identifier
Formula	C29 H35 F3 N2 O3
Molecular Weight	516.595
SMILES
PubChem	72959169
Formal Charge	0
Total Atoms	72
Total Chiral Atoms	0
Total Bonds	75
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9H228
Sequence	>7EW1_nogp_Chain_R V I V L H Y N Y T G K L R G R A D A V V C L A V C A F I V L E N L A V L L V L G R H A P M F L L L G S L T L S D L L A G A A Y A A N I L L S G P L T L K L S P A L W F A R E G G V F V A L T A S V L S L L A I A L E R S L T M A R R G P A P V S S R G R T L A M A A A A W G V S L L L G L L P A L G W N C L G R L D A C S T V L P L Y A K A Y V L F C V L A F V G I L A A I C A L Y A R I Y C Q V R A N A R R L R K P R S L A L L R T L S V V L L A F V A C W G P L F L L L L L D V A C P A R T C P V L L Q A D P F L G L A M A N S L L N P I I Y T L T N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7EW1	A	Lipid	Lysophospholipid	S1P₅	Homo sapiens	Siponimod	-	Gi1/β1/γ2	3.4	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7EW1 (No Gprot)	A	Lipid	Lysophospholipid	S1P₅	Homo sapiens	Siponimod	-		3.4	2021-09-29	doi.org/10.1038/s41422-021-00566-x
	7YXA	A	Lipid	Lysophospholipid	S1P₅	Homo sapiens	ONO-5430608	-	-	2.2	2022-08-10	doi.org/10.1038/s41467-022-32447-1

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7EW1_nogp.zip

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