Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 5.8054125
2A:A:L39 4.435409
3A:A:K46 3.445209
4A:A:I184 5.725419
5A:A:L194 4.294124
6A:A:F196 8.2925127
7A:A:M198 5.3375407
8A:A:F199 8.20833615
9A:A:Q204 5.45333619
10A:A:S206 5.425418
11A:A:K210 6.11625819
12A:A:W211 6.08667619
13A:A:F215 5.84286719
14A:A:I222 5.08254187
15A:A:F223 7.365409
16A:A:C224 3.68254207
17A:A:Y230 6.10286758
18A:A:R242 8.99459
19A:A:F250 6.74857799
20A:A:C254 4.27595
21A:A:W258 8.13515
22A:A:F259 6.8654199
23A:A:I265 3.49754188
24A:A:F274 4.785459
25A:A:P282 3.8425455
26A:A:L283 5.58407
27A:A:Y287 6.558557
28A:A:Y290 7.8175407
29A:A:Y302 8.804556
30A:A:F307 6.39408
31A:A:Y320 8.85407
32A:A:C325 4.3575407
33A:A:N331 6.311676138
34A:A:K349 7.12405
35A:A:F354 7.628525
36G:G:K20 6.71254146
37G:G:Y40 6.6354156
38G:G:D48 8.6775409
39G:G:L51 5.34506
40G:G:P60 6.405449
41G:G:F61 5.15625848
42R:R:S37 2.2075407
43R:R:R62 7.156527
44R:R:M68 6.025427
45R:R:W71 9.05408
46R:R:L75 5.485425
47R:R:L76 3.6625404
48R:R:W82 6.1345237
49R:R:V83 3.13505
50R:R:K86 5.264239
51R:R:L106 4.084247
52R:R:M109 5.54667626
53R:R:H115 6.57167628
54R:R:M118 9.7425429
55R:R:V139 5.5325408
56R:R:E176 7.24288
57R:R:P178 3.854165
58R:R:H183 6.594288
59R:R:Q187 8.16754287
60R:R:I209 3.7725406
61R:R:K211 7.6354269
62R:R:F217 7.65508
63R:R:W238 7.51167628
64R:R:L245 2.73407
65R:R:F256 8.8325405
66R:R:E260 8.285405
67R:R:Y266 8.2845226
68R:R:Y282 8.292527
69R:R:F286 6.68875826
70B:B:V40 3.7685103
71B:B:H54 8.61167649
72B:B:Y59 8.624518
73B:B:W63 5.71167607
74B:B:D76 7.24449
75B:B:L79 5.1975477
76B:B:I80 8.3325448
77B:B:I81 5.09477
78B:B:W82 8.42286749
79B:B:N88 6.29407
80B:B:K89 6.97667649
81B:B:H91 5.6175405
82B:B:I93 6.1475407
83B:B:L95 4.214578
84B:B:W99 6.66857719
85B:B:Y105 4.35571776
86B:B:N110 5.4825484
87B:B:Y111 5.23684
88B:B:V112 4.215478
89B:B:C114 4.2425478
90B:B:L117 5.63519
91B:B:I123 3.61833686
92B:B:Y124 5.19667676
93B:B:L126 4.185475
94B:B:H142 7.17833619
95B:B:Y145 5.95429718
96B:B:C149 4.28408
97B:B:F151 4.54167689
98B:B:T159 5.785419
99B:B:S160 5.575436
100B:B:D163 7.948519
101B:B:C166 3.736538
102B:B:W169 8.45667618
103B:B:F180 8.19537
104B:B:H183 8.40833639
105B:B:D186 5.2325419
106B:B:V187 5.238539
107B:B:L190 5.005435
108B:B:F199 6.946539
109B:B:S201 5.225439
110B:B:C204 3.5625417
111B:B:D205 7.178539
112B:B:K209 9.728536
113B:B:L210 5.34405
114B:B:W211 8.51167638
115B:B:Q220 7.3875467
116B:B:F222 6.1675468
117B:B:H225 9.27857769
118B:B:D228 7.854519
119B:B:I229 5.8775467
120B:B:I232 5.4825468
121B:B:F234 4.516505
122B:B:F235 5.47156
123B:B:F241 8.728566
124B:B:T243 7468
125B:B:D246 8.8825419
126B:B:D247 6.8375469
127B:B:R251 7.74668
128B:B:F253 6.385666
129B:B:D258 7.898567
130B:B:M262 7.85404
131B:B:Y264 6.656505
132B:B:F278 6.9675407
133B:B:R283 7.8525109
134B:B:L285 4.79406
135B:B:Y289 6.966177
136B:B:W297 6.47254178
137B:B:D298 8.07254109
138B:B:R304 7.5985175
139B:B:H311 8.8325119
140B:B:R314 12.6375418
141B:B:V327 4.1825406
142B:B:W332 12.3719
143B:B:D333 7.434119
144B:B:L336 4.22447
145B:B:K337 7.984116
146B:B:I338 4.485445
147B:B:W339 10.3945119
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:A328 B:B:W63 15.79053.89NoYes057
2B:B:A328 B:B:M61 15.873.22NoNo056
3B:B:C317 B:B:M61 15.95098.1NoNo076
4B:B:C317 B:B:S316 16.03593.44NoNo079
5B:B:S316 B:B:W332 16.12154.94NoYes099
6B:B:W332 B:B:Y59 25.727112.54YesYes198
7B:B:Q75 B:B:Y59 15.194713.53NoYes198
8B:B:Q75 B:B:W99 15.32996.57NoYes199
9A:A:F215 B:B:W99 16.38128.02YesYes199
10A:A:F215 A:A:L37 58.49829.74YesNo099
11A:A:L37 A:A:L39 58.44235.54NoYes099
12A:A:I253 A:A:L39 1004.28NoYes089
13A:A:F223 A:A:I253 99.55846.28YesNo098
14A:A:F223 A:A:G40 74.12083.01YesNo099
15A:A:G40 A:A:K46 73.95933.49NoYes099
16A:A:C224 A:A:K46 72.40323.23YesYes2079
17A:A:C224 A:A:I49 72.10874.91YesNo077
18A:A:I49 A:A:L38 71.81354.28NoNo078
19A:A:I222 A:A:L38 63.99764.28YesNo078
20A:A:C214 B:B:Y59 11.05926.72NoYes178
21A:A:C214 B:B:L117 11.30943.17NoYes179
22A:A:I212 A:A:W211 42.08213.52NoYes089
23A:A:I212 A:A:R208 41.59825.01NoNo089
24A:A:F223 A:A:F250 36.464112.86YesYes099
25A:A:F250 A:A:L266 16.21647.31YesNo099
26A:A:L266 A:A:T321 16.00917.37NoNo095
27A:A:Q304 A:A:T321 15.801917.01NoNo2155
28A:A:F323 A:A:Q304 31.22068.2NoNo045
29A:A:F323 A:A:L268 30.37746.09NoNo048
30A:A:L227 A:A:L268 29.95554.15NoNo078
31A:A:F274 A:A:L227 20.1176.09YesNo597
32A:A:F250 A:A:I319 16.64185.02YesNo095
33A:A:E308 A:A:I319 16.04788.2NoNo035
34A:A:E308 A:A:Q304 15.83998.92NoNo2135
35A:A:Q204 B:B:L117 11.57335.32YesYes199
36A:A:Q204 B:B:N119 25.97123.96YesNo199
37A:A:S206 A:A:W211 42.02334.94YesYes189
38A:A:Q204 B:B:Y145 27.23394.51YesYes198
39A:A:S206 B:B:D186 20.66515.89YesYes189
40A:A:I222 A:A:I265 59.91514.42YesYes1878
41A:A:F274 A:A:Y230 12.03166.19YesYes598
42A:A:A338 A:A:I265 59.78023.25NoYes068
43A:A:A338 A:A:Y320 59.60786.67NoYes067
44A:A:E318 A:A:Y320 59.092113.47NoYes047
45A:A:E318 R:R:F217 59.20313.5NoYes048
46A:A:K345 R:R:F217 53.190616.13NoYes058
47A:A:K345 A:A:K349 53.010710.06NoYes055
48A:A:F354 A:A:K349 51.74718.69YesYes055
49A:A:F354 R:R:F286 49.64014.29YesYes256
50R:R:F286 R:R:M68 45.768412.44YesYes267
51R:R:M68 R:R:Y282 45.2283.59YesYes277
52R:R:M118 R:R:Y282 12.159519.16YesYes297
53B:B:G144 B:B:N119 25.8793.39NoNo089
54B:B:D163 B:B:G144 25.77033.35YesNo098
55B:B:D163 B:B:H142 25.43498.82YesYes199
56B:B:H142 B:B:T159 78.17096.85YesYes199
57B:B:C121 B:B:T159 77.88253.38NoYes089
58B:B:C121 B:B:C149 77.60023.64NoYes088
59B:B:C149 B:B:T102 76.74516.76YesNo088
60B:B:C148 B:B:T102 76.3163.38NoNo068
61B:B:C148 B:B:L190 76.52873.17NoYes065
62B:B:F199 B:B:L190 65.22094.87YesYes395
63B:B:F199 B:B:W211 58.515811.02YesYes398
64B:B:K209 B:B:W211 54.14169.28YesYes368
65B:B:K209 B:B:T221 52.955313.51YesNo067
66B:B:T221 G:G:E22 52.50867.06NoNo079
67B:B:I18 G:G:E22 21.66098.2NoNo079
68B:B:I18 G:G:A23 17.76683.25NoNo078
69B:B:L14 G:G:L19 14.96972.77NoNo089
70B:B:K15 G:G:L19 14.03537.05NoNo069
71B:B:A11 B:B:K15 13.10091.61NoNo056
72B:B:A11 G:G:V16 12.16621.7NoNo057
73B:B:E10 G:G:V16 11.23131.43NoNo087
74B:B:G162 B:B:Y145 45.96897.24NoYes198
75B:B:G162 B:B:S161 65.8963.71NoNo199
76B:B:H142 B:B:S161 65.589812.55YesNo199
77B:B:D258 G:G:E22 30.79453.9YesNo079
78B:B:D258 B:B:Q220 10.678411.75YesYes677
79R:R:H115 R:R:Y282 31.08126.53YesYes287
80R:R:H115 R:R:W238 23.6236.35YesYes288
81R:R:V112 R:R:W238 21.63112.26NoYes268
82R:R:M109 R:R:V112 20.58743.04YesNo266
83R:R:F105 R:R:M109 13.29217.46NoYes066
84R:R:F105 R:R:K190 13.079321.09NoNo069
85R:R:E176 R:R:K190 12.866312.15YesNo089
86R:R:I279 R:R:L75 11.76634.28NoYes095
87R:R:I279 R:R:L76 11.34785.71NoYes094
88B:B:H142 B:B:W169 11.56384.23YesYes198
89B:B:D258 B:B:F222 14.39314.78YesYes678
90A:A:L39 A:A:R208 41.54283.64YesNo099
91A:A:F215 A:A:W211 42.14884.01YesYes199
92B:B:D186 B:B:G162 20.23025.03YesNo199
93A:A:Q204 A:A:W211 41.92619.86YesYes199
94A:A:S206 B:B:Y145 21.32265.09YesYes188
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7JHJ
Class A
SubFamily Other
Type Unclassified
SubType BILF1
Species Human Gammaherpesvirus 4
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.2
Date 2021-07-07
D.O.I. 10.1016/j.immuni.2021.06.001
Net Summary
Imin 3.01
Number of Linked Nodes 830
Number of Links 992
Number of Hubs 147
Number of Links mediated by Hubs 559
Number of Communities 29
Number of Nodes involved in Communities 219
Number of Links involved in Communities 314
Path Summary
Number Of Nodes in MetaPath 95
Number Of Links MetaPath 94
Number of Shortest Paths 1547257
Length Of Smallest Path 3
Average Path Length 35.7597
Length of Longest Path 73
Minimum Path Strength 1.115
Average Path Strength 6.4041
Maximum Path Strength 25.34
Minimum Path Correlation 0.7
Average Path Correlation 0.983047
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.43902
Average % Of Corr. Nodes 40.5913
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.0808
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7JHJ_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKST 
IVKQMKITG IVETHFTFK DLHFKMFDV GGQRSERKK WIHCFEGVT 
AIIFCVALS DYDLVNRMH ESMKLFDSI CNNKWFTDT SIILFLNKK 
DLFEEKIKK SPLTICYPE YAGSNTYEE AAAYIQCQF EDLNKRKDT 
KEIYTHFTC ATDTKNVQF VFDAVTDVI IKNNLKDCG LF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7JHJ_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ3KSP2
Sequence
>7JHJ_Chain_R
CTKSYSAFL SGMTSLLLV LLILLTLAG ILFIIFVRK LVHRMDVWL 
IALLIELLL WVLGKMIQE FSSTGLCLL TQNMMFLGL MCSVWTHLG 
MALEKTLAL FSRTPKRTS HRNVCLYLM GVFCLVLLL IIILLITMG 
PDANLNRGP NMCREGPTK GMHTAVQGL KAGCYLLAA VLIVLLTVI 
IIWKLLRTK FGRKPRLIC NVTFTGLIC AFSWFMLSL PLLFLGEAG 
SLGFDCTES LVARYYPGP AACLALLLI ILYAWSFSH FMDSLKNQV 
TVTARYF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7JHJ_Chain_B
DQLRQEAEQ LKNQIRDAR KACADATLS QITNNIDPV GRIQMRTRR 
TLRGHLAKI YAMHWGTDS RLLVSASQD GKLIIWDSY TTNKVHAIP 
LRSSWVMTC AYAPSGNYV ACGGLDNIC SIYNLKTRE GNVRVSREL 
AGHTGYLSC CRFLDDNQI VTSSGDTTC ALWDIETGQ QTTTFTGHT 
GDVMSLSLA PDTRLFVSG ACDASAKLW DVREGMCRQ TFTGHESDI 
NAICFFPNG NAFATGSDD ATCRLFDLR ADQELMTYS HDNIICGIT 
SVSFSKSGR LLLAGYDDF NCNVWDALK ADRAGVLAG HDNRVSCLG 
VTDDGMAVA TGSWDSFLK IWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7JHJAOtherUnclassifiedBILF1Human gammaherpesvirus 4--Gi1/&β;1/&γ;23.22021-07-0710.1016/j.immuni.2021.06.001




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Download 7JHJ.zip



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