Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 5.8054115
2A:A:L39 4.435409
3A:A:K46 3.445189
4A:A:I184 5.725419
5A:A:L194 4.294114
6A:A:F196 8.2925117
7A:A:M198 5.3375407
8A:A:F199 8.20833615
9A:A:Q204 5.45333619
10A:A:S206 5.425418
11A:A:K210 5.96429719
12A:A:W211 6.08667619
13A:A:F215 5.84286719
14A:A:I222 5.08254167
15A:A:F223 7.365409
16A:A:C224 3.68254187
17A:A:Y230 6.10286768
18A:A:F250 6.74857799
19A:A:C254 4.27595
20A:A:W258 8.13515
21A:A:F259 6.8654179
22A:A:I265 3.49754168
23A:A:F274 4.785469
24A:A:P282 3.8425465
25A:A:L283 5.58407
26A:A:Y287 5.938507
27A:A:Y290 7.8175407
28A:A:Y302 8.13506
29A:A:F307 6.39408
30A:A:Y320 8.85407
31A:A:C325 4.3575407
32A:A:N331 6.311676128
33A:A:K349 7.12405
34A:A:F354 7.628525
35B:B:L7 4.7675408
36B:B:V40 3.7685203
37B:B:H54 8.61167649
38B:B:Y59 8.624518
39B:B:W63 5.71167607
40B:B:D76 7.24449
41B:B:L79 5.1975477
42B:B:I80 8.3325448
43B:B:I81 5.09477
44B:B:W82 8.42286749
45B:B:N88 6.29407
46B:B:K89 6.97667649
47B:B:H91 5.6175405
48B:B:I93 6.1475407
49B:B:L95 4.214578
50B:B:W99 6.66857719
51B:B:Y105 4.35571776
52B:B:N110 5.4825484
53B:B:Y111 5.23684
54B:B:V112 4.215478
55B:B:C114 4.2425478
56B:B:L117 5.63519
57B:B:I123 3.61833686
58B:B:Y124 5.19667676
59B:B:L126 4.185475
60B:B:H142 7.17833619
61B:B:Y145 5.95429718
62B:B:C149 4.28408
63B:B:F151 4.54167689
64B:B:T159 5.785419
65B:B:S160 5.575436
66B:B:D163 7.948519
67B:B:C166 3.736538
68B:B:W169 8.45667618
69B:B:F180 8.19537
70B:B:H183 8.40833639
71B:B:D186 5.2325419
72B:B:V187 5.238539
73B:B:L190 5.005435
74B:B:F199 6.946539
75B:B:S201 5.225439
76B:B:C204 3.5625417
77B:B:D205 7.178539
78B:B:K209 9.728536
79B:B:L210 5.34405
80B:B:W211 8.51167638
81B:B:Q220 7.3875457
82B:B:F222 6.1675458
83B:B:H225 9.27857759
84B:B:D228 8.09419
85B:B:I229 5.8775457
86B:B:I232 5.4825458
87B:B:F234 4.516505
88B:B:F235 5.47136
89B:B:F241 8.728556
90B:B:T243 7458
91B:B:D246 8.8825419
92B:B:D247 6.8375459
93B:B:R251 7.74658
94B:B:F253 6.385656
95B:B:D258 7.898557
96B:B:M262 7.85404
97B:B:Y264 6.656505
98B:B:F278 6.9675407
99B:B:R283 7.8525209
100B:B:L285 4.79406
101B:B:Y289 6.966147
102B:B:W297 6.47254148
103B:B:D298 8.07254209
104B:B:R304 7.5985145
105B:B:H311 8.8325109
106B:B:R314 12.6375418
107B:B:V327 4.1825406
108B:B:W332 12.3719
109B:B:D333 7.434109
110B:B:L336 4.22447
111B:B:K337 7.984106
112B:B:I338 4.485445
113B:B:W339 10.3945109
114G:G:Y40 6.6354136
115G:G:D48 8.6775409
116G:G:L51 5.34506
117G:G:P60 6.405449
118G:G:F61 5.15625848
119R:R:S37 2.2075407
120R:R:R62 7.156527
121R:R:M68 6.025427
122R:R:W71 9.05408
123R:R:L75 5.485425
124R:R:L76 3.6625404
125R:R:W82 6.1345237
126R:R:V83 3.13505
127R:R:K86 5.264239
128R:R:L106 4.084247
129R:R:M109 5.54667626
130R:R:H115 6.57167628
131R:R:M118 9.7425429
132R:R:V139 5.5325408
133R:R:L167 3.59754158
134R:R:E176 7.24278
135R:R:P178 3.854155
136R:R:H183 6.594278
137R:R:Q187 8.16754277
138R:R:I209 3.7725406
139R:R:K211 7.6354269
140R:R:F217 7.65508
141R:R:W238 7.51167628
142R:R:L245 2.73407
143R:R:E260 7.23405
144R:R:Y266 8.2845226
145R:R:Y282 8.292527
146R:R:F286 6.68875826
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:A328 B:B:W63 16.14773.89NoYes057
2B:B:A328 B:B:M61 16.22783.22NoNo056
3B:B:C317 B:B:M61 16.30948.1NoNo076
4B:B:C317 B:B:S316 16.39513.44NoNo079
5B:B:S316 B:B:W332 16.48134.94NoYes099
6B:B:W332 B:B:Y59 26.082512.54YesYes198
7B:B:Q75 B:B:Y59 15.758813.53NoYes198
8B:B:Q75 B:B:W99 15.89566.57NoYes199
9A:A:F215 B:B:W99 17.00358.02YesYes199
10A:A:F215 A:A:L37 58.81169.74YesNo099
11A:A:L37 A:A:L39 58.75855.54NoYes099
12A:A:I253 A:A:L39 1004.28NoYes089
13A:A:F223 A:A:I253 99.57026.28YesNo098
14A:A:F223 A:A:G40 75.8113.01YesNo099
15A:A:G40 A:A:K46 75.65463.49NoYes099
16A:A:C224 A:A:K46 74.13753.23YesYes1879
17A:A:C224 A:A:I49 73.85494.91YesNo077
18A:A:I49 A:A:L38 73.57144.28NoNo078
19A:A:I222 A:A:L38 66.0584.28YesNo078
20A:A:C214 B:B:Y59 10.85566.72NoYes178
21A:A:C214 B:B:L117 11.11033.17NoYes179
22A:A:I212 A:A:W211 41.74593.52NoYes089
23A:A:I212 A:A:R208 41.2695.01NoNo089
24A:A:F223 A:A:F250 35.041612.86YesYes099
25A:A:F250 A:A:L266 15.5127.31YesNo099
26A:A:L266 A:A:T321 15.30557.37NoNo095
27A:A:Q304 A:A:T321 15.09917.01NoNo1955
28A:A:F323 A:A:Q304 29.81558.2NoNo045
29A:A:F323 A:A:L268 28.97556.09NoNo048
30A:A:L227 A:A:L268 28.55524.15NoNo078
31A:A:F274 A:A:L227 18.75656.09YesNo697
32A:A:F250 A:A:I319 15.93565.02YesNo095
33A:A:E308 A:A:I319 15.34338.2NoNo035
34A:A:E308 A:A:Q304 15.13618.92NoNo1935
35A:A:Q204 B:B:L117 11.34675.32YesYes199
36A:A:Q204 B:B:N119 25.65833.96YesNo199
37A:A:S206 A:A:W211 41.67554.94YesYes189
38A:A:Q204 B:B:Y145 26.95984.51YesYes198
39A:A:S206 B:B:D186 20.47715.89YesYes189
40A:A:I222 A:A:I265 62.034.42YesYes1678
41A:A:F274 A:A:Y230 10.69976.19YesYes698
42A:A:A338 A:A:I265 61.92043.25NoYes068
43A:A:A338 A:A:Y320 61.7536.67NoYes067
44A:A:E318 A:A:Y320 61.252513.47NoYes047
45A:A:E318 R:R:F217 61.4073.5NoYes048
46A:A:K345 R:R:F217 55.563316.13NoYes058
47A:A:K345 A:A:K349 55.388410.06NoYes055
48A:A:F354 A:A:K349 54.1598.69YesYes055
49A:A:F354 R:R:F286 52.09674.29YesYes256
50R:R:F286 R:R:M68 49.050312.44YesYes267
51R:R:M68 R:R:Y282 48.52843.59YesYes277
52R:R:M118 R:R:Y282 14.186619.16YesYes297
53B:B:G144 B:B:N119 25.56113.39NoNo089
54B:B:D163 B:B:G144 25.44793.35YesNo098
55B:B:D163 B:B:H142 25.09978.82YesYes199
56B:B:H142 B:B:T159 76.64316.85YesYes199
57B:B:C121 B:B:T159 76.33663.38NoYes089
58B:B:C121 B:B:C149 76.03553.64NoYes088
59B:B:C149 B:B:T102 75.12466.76YesNo088
60B:B:C148 B:B:T102 74.68033.38NoNo068
61B:B:C148 B:B:L190 74.84343.17NoYes065
62B:B:F199 B:B:L190 63.16164.87YesYes395
63B:B:F199 B:B:W211 56.227711.02YesYes398
64B:B:K209 B:B:W211 51.69459.28YesYes368
65B:B:K209 B:B:T221 49.990213.51YesNo067
66B:B:T221 G:G:E22 49.52787.06NoNo079
67B:B:D258 G:G:E22 36.90873.9YesNo079
68B:B:D258 B:B:Q220 16.655511.75YesYes577
69B:B:L210 B:B:Q220 15.77566.65YesYes057
70B:B:G162 B:B:Y145 45.43457.24NoYes198
71B:B:G162 B:B:S161 65.14433.71NoNo199
72B:B:H142 B:B:S161 64.826812.55YesNo199
73B:B:I18 G:G:E22 12.3768.2NoNo079
74B:B:H142 B:B:W169 11.94834.23YesYes198
75B:B:D258 B:B:F222 14.75214.78YesYes578
76R:R:H115 R:R:Y282 32.39376.53YesYes287
77R:R:H115 R:R:W238 22.38676.35YesYes288
78R:R:V112 R:R:W238 20.427612.26NoYes268
79R:R:M109 R:R:V112 19.40123.04YesNo266
80R:R:F105 R:R:M109 12.43047.46NoYes066
81R:R:F105 R:R:K190 12.221121.09NoNo069
82R:R:E176 R:R:K190 12.011512.15YesNo089
83R:R:I279 R:R:L75 16.84164.28NoYes095
84R:R:I279 R:R:L76 16.43025.71NoYes094
85R:R:L76 R:R:T51 12.31032.95YesNo046
86R:R:L79 R:R:T51 11.10572.95NoNo056
87R:R:L79 R:R:V83 10.30482.98NoYes055
88A:A:L39 A:A:R208 41.21633.64YesNo099
89A:A:F215 A:A:W211 41.80394.01YesYes199
90B:B:D186 B:B:G162 20.02425.03YesNo199
91A:A:Q204 A:A:W211 41.57639.86YesYes199
92A:A:S206 B:B:Y145 21.15915.09YesYes188
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7JHJ
Class A
SubFamily Other
Type Unclassified
SubType BILF1
Species Human Gammaherpesvirus 4
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.2
Date 2021-07-07
D.O.I. 10.1016/j.immuni.2021.06.001
Net Summary
Imin 3.01
Number of Linked Nodes 831
Number of Links 986
Number of Hubs 146
Number of Links mediated by Hubs 553
Number of Communities 27
Number of Nodes involved in Communities 205
Number of Links involved in Communities 296
Path Summary
Number Of Nodes in MetaPath 93
Number Of Links MetaPath 92
Number of Shortest Paths 1516196
Length Of Smallest Path 3
Average Path Length 35.8945
Length of Longest Path 71
Minimum Path Strength 1.115
Average Path Strength 6.40043
Maximum Path Strength 25.34
Minimum Path Correlation 0.7
Average Path Correlation 0.982633
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.32558
Average % Of Corr. Nodes 39.7007
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.5595
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • protein serine/threonine kinase activity   • enzyme regulator activity   • catalytic activity, acting on a protein   • kinase activity   • protein kinase activity   • transferase activity   • enzyme inhibitor activity   • protein kinase regulator activity   • phosphotransferase activity, alcohol group as acceptor   • transferase activity, transferring phosphorus-containing groups   • protein kinase inhibitor activity   • molecular function inhibitor activity   • molecular function regulator activity   • protein serine/threonine kinase inhibitor activity   • kinase inhibitor activity   • kinase regulator activity   • symbiont-mediated perturbation of host defense response   • biological process involved in interspecies interaction between organisms   • symbiont-mediated perturbation of host immune response   • biological process involved in interaction with host   • biological process involved in symbiotic interaction   • symbiont-mediated suppression of host immune response   • symbiont-mediated perturbation of host process   • symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I   • symbiont-mediated suppression of host antigen processing and presentation   • modulation of process of another organism   • symbiont-mediated suppression of host adaptive immune response   • symbiont-mediated perturbation of host cellular process   • response to other organism   • symbiont-mediated perturbation of host defenses   • symbiont-mediated suppression of host PKR/eIFalpha signaling   • symbiont-mediated response to host defenses   • response to external stimulus   • response to biotic stimulus   • symbiont-mediated suppression of host signal transduction pathway   • symbiont-mediated suppression of host-directed shutoff of host translation   • symbiont-mediated suppression of host defenses   • response to host   • response to external biotic stimulus   • symbiont-mediated perturbation of host signal transduction pathway   • symbiont-mediated suppression of host innate immune response   • symbiont-mediated perturbation of host innate immune response   • symbiont-mediated suppression of host interferon-mediated signaling pathway   • symbiont-mediated suppression of host type I interferon-mediated signaling pathway   • positive regulation of response to biotic stimulus   • pattern recognition receptor signaling pathway   • regulation of NLRP3 inflammasome complex assembly   • negative regulation of biological process   • regulation of signal transduction   • cellular component biogenesis   • immune response-activating signaling pathway   • cellular component assembly   • inflammasome-mediated signaling pathway   • positive regulation of immune response   • canonical inflammasome complex assembly   • regulation of immune system process   • negative regulation of NLRP3 inflammasome complex assembly   • positive regulation of immune system process   • innate immune response-activating signaling pathway   • negative regulation of cellular component organization   • immune response   • regulation of innate immune response   • regulation of inflammasome-mediated signaling pathway   • negative regulation of protein-containing complex assembly   • regulation of response to stimulus   • defense response to other organism   • regulation of pattern recognition receptor signaling pathway   • NLRP3 inflammasome complex assembly   • positive regulation of defense response   • activation of innate immune response   • regulation of immune response   • inflammatory response   • activation of immune response   • cytoplasmic pattern recognition receptor signaling pathway   • regulation of defense response   • regulation of response to biotic stimulus   • regulation of cellular component organization   • regulation of response to external stimulus   • intracellular receptor signaling pathway   • negative regulation of signaling   • negative regulation of cytoplasmic pattern recognition receptor signaling pathway   • negative regulation of intracellular signal transduction   • positive regulation of biological process   • regulation of cytoplasmic pattern recognition receptor signaling pathway   • negative regulation of cell communication   • positive regulation of response to stimulus   • cellular component organization   • regulation of protein-containing complex assembly   • positive regulation of response to external stimulus   • immune response-regulating signaling pathway   • regulation of intracellular signal transduction   • regulation of response to stress   • response to stress   • innate immune response   • negative regulation of cellular process   • protein-containing complex assembly   • cellular component organization or biogenesis   • regulation of signaling   • positive regulation of innate immune response   • defense response   • negative regulation of response to stimulus   • protein-containing complex organization   • defense response to symbiont   • regulation of cellular component biogenesis   • negative regulation of signal transduction   • negative regulation of immune system process   • immune system process   • regulation of cell communication   • negative regulation of inflammasome-mediated signaling pathway   • host cellular component   • host intracellular membrane-bounded organelle   • host intracellular part   • host cell membrane   • host cell mitochondrion   • host cell cytoplasm part   • host intracellular organelle   • host organelle outer membrane   • host cell cytoplasm   • host cell part   • host cell mitochondrial envelope   • host intracellular region   • host cell mitochondrial outer membrane   • host cell mitochondrial membrane   • host outer membrane   • mitochondrial membrane   • mitochondrion   • organelle outer membrane   • organelle envelope   • mitochondrial envelope   • mitochondrial outer membrane   • outer membrane   • host cell plasma membrane
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7JHJ_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKST 
IVKQMKITG IVETHFTFK DLHFKMFDV GGQRSERKK WIHCFEGVT 
AIIFCVALS DYDLVNRMH ESMKLFDSI CNNKWFTDT SIILFLNKK 
DLFEEKIKK SPLTICYPE YAGSNTYEE AAAYIQCQF EDLNKRKDT 
KEIYTHFTC ATDTKNVQF VFDAVTDVI IKNNLKDCG LF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7JHJ_Chain_B
DQLRQEAEQ LKNQIRDAR KACADATLS QITNNIDPV GRIQMRTRR 
TLRGHLAKI YAMHWGTDS RLLVSASQD GKLIIWDSY TTNKVHAIP 
LRSSWVMTC AYAPSGNYV ACGGLDNIC SIYNLKTRE GNVRVSREL 
AGHTGYLSC CRFLDDNQI VTSSGDTTC ALWDIETGQ QTTTFTGHT 
GDVMSLSLA PDTRLFVSG ACDASAKLW DVREGMCRQ TFTGHESDI 
NAICFFPNG NAFATGSDD ATCRLFDLR ADQELMTYS HDNIICGIT 
SVSFSKSGR LLLAGYDDF NCNVWDALK ADRAGVLAG HDNRVSCLG 
VTDDGMAVA TGSWDSFLK IWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7JHJ_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ3KSP2
Sequence
>7JHJ_Chain_R
CTKSYSAFL SGMTSLLLV LLILLTLAG ILFIIFVRK LVHRMDVWL 
IALLIELLL WVLGKMIQE FSSTGLCLL TQNMMFLGL MCSVWTHLG 
MALEKTLAL FSRTPKRTS HRNVCLYLM GVFCLVLLL IIILLITMG 
PDANLNRGP NMCREGPTK GMHTAVQGL KAGCYLLAA VLIVLLTVI 
IIWKLLRTK FGRKPRLIC NVTFTGLIC AFSWFMLSL PLLFLGEAG 
SLGFDCTES LVARYYPGP AACLALLLI ILYAWSFSH FMDSLKNQV 
TVTARYF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7JHJAOtherUnclassifiedBILF1Human gammaherpesvirus 4--Gi1/β1/γ23.22021-07-0710.1016/j.immuni.2021.06.001
7JHJ (No Gprot) AOtherUnclassifiedBILF1Human gammaherpesvirus 4--3.22021-07-0710.1016/j.immuni.2021.06.001




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