psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C258	R:R:C28	7.28	No	No	0	9	9
2	R:R:K30	R:R:P171	8.36	No	No	0	3	5
3	R:R:E260	R:R:K30	4.05	Yes	No	0	5	3
4	R:R:L36	R:R:S33	6.01	No	No	3	8	6
5	R:R:S33	R:R:Y266	5.09	No	Yes	3	6	6
6	R:R:L36	R:R:Y266	12.89	No	Yes	3	8	6
7	R:R:S37	R:R:Y266	3.82	Yes	Yes	0	7	6
8	R:R:G38	R:R:S41	3.71	No	No	0	4	4
9	R:R:M39	R:R:P270	3.35	No	No	0	5	5
10	R:R:T40	R:R:Y266	6.24	No	Yes	0	7	6
11	R:R:L43	R:R:P270	3.28	No	No	0	5	5
12	R:R:C273	R:R:L43	3.17	No	No	0	4	5
13	R:R:L44	R:R:V83	4.47	No	Yes	0	7	5
14	R:R:K86	R:R:L44	4.23	Yes	No	0	9	7
15	R:R:L46	R:R:L50	4.15	No	No	0	5	5
16	R:R:L47	R:R:V83	2.98	No	Yes	0	5	5
17	R:R:C273	R:R:L47	3.17	No	No	0	4	5
18	R:R:L276	R:R:L47	5.54	No	No	0	7	5
19	R:R:L76	R:R:T51	2.95	Yes	No	0	4	6
20	R:R:L79	R:R:T51	2.95	Yes	No	0	5	6
21	R:R:L52	R:R:L80	4.15	No	No	0	5	5
22	R:R:I55	R:R:I73	4.42	No	No	5	6	1
23	R:R:I55	R:R:L76	4.28	No	Yes	0	6	4
24	R:R:I55	R:R:I77	2.94	No	No	5	6	4
25	R:R:F57	R:R:V61	7.87	No	No	6	7	7
26	R:R:F57	R:R:L293	4.87	No	No	0	7	8
27	R:R:F57	R:R:Q296	4.68	No	Yes	6	7	5
28	R:R:I58	R:R:L64	2.85	No	No	0	7	5
29	R:R:I58	R:R:I73	8.83	No	No	0	7	1
30	R:R:I59	R:R:L64	2.85	No	No	0	3	5
31	R:R:Q296	R:R:V61	2.87	Yes	No	6	5	7
32	R:R:R62	R:R:V65	5.23	Yes	No	0	7	4
33	R:R:D69	R:R:R62	19.06	No	Yes	1	8	7
34	R:R:F286	R:R:R62	3.21	Yes	Yes	1	6	7
35	R:R:H288	R:R:R62	5.64	No	Yes	1	6	7
36	R:R:D69	R:R:H66	3.78	No	No	1	8	7
37	R:R:F286	R:R:H66	16.97	Yes	No	1	6	7
38	R:R:R67	R:R:W71	3	Yes	Yes	1	4	8
39	R:R:E121	R:R:R67	10.47	No	Yes	1	7	4
40	R:R:H136	R:R:R67	3.39	No	Yes	0	3	4
41	R:R:M118	R:R:M68	2.89	Yes	Yes	1	9	7
42	R:R:M68	R:R:Y282	3.59	Yes	Yes	1	7	7
43	R:R:F286	R:R:M68	12.44	Yes	Yes	1	6	7
44	R:R:D69	R:R:F286	3.58	No	Yes	1	8	6
45	R:R:H136	R:R:V70	6.92	No	No	0	3	3
46	R:R:V139	R:R:V70	6.41	Yes	No	0	8	3
47	R:R:M118	R:R:W71	11.63	Yes	Yes	1	9	8
48	R:R:E121	R:R:W71	8.72	No	Yes	1	7	8
49	R:R:V139	R:R:W71	11.03	Yes	Yes	0	8	8
50	R:R:W71	R:R:Y142	4.82	Yes	Yes	0	8	7
51	R:R:A283	R:R:L72	3.15	No	No	0	5	9
52	R:R:I73	R:R:I77	4.42	No	No	5	1	4
53	R:R:A74	R:R:L143	4.73	No	No	0	5	5
54	R:R:L75	R:R:T114	4.42	Yes	No	0	5	5
55	R:R:H115	R:R:L75	9	Yes	Yes	1	8	5
56	R:R:L75	R:R:M118	4.24	Yes	Yes	1	5	9
57	R:R:I279	R:R:L75	4.28	No	Yes	0	9	5
58	R:R:I279	R:R:L76	5.71	No	Yes	0	9	4
59	R:R:C110	R:R:E78	7.6	No	No	0	3	5
60	R:R:E78	R:R:S111	8.62	No	No	0	5	7
61	R:R:E78	R:R:T114	9.88	No	No	0	5	5
62	R:R:L79	R:R:V83	2.98	Yes	Yes	0	5	5
63	R:R:I279	R:R:L79	2.85	No	Yes	0	9	5
64	R:R:L106	R:R:L81	5.54	Yes	No	7	7	5
65	R:R:V83	R:R:W82	3.68	Yes	Yes	0	5	7
66	R:R:K86	R:R:W82	5.8	Yes	Yes	4	9	7
67	R:R:M104	R:R:W82	10.47	No	Yes	4	7	7
68	R:R:L108	R:R:W82	6.83	No	Yes	0	6	7
69	R:R:A272	R:R:W82	3.89	No	Yes	0	6	7
70	R:R:G85	R:R:M103	5.24	No	No	0	6	5
71	R:R:K86	R:R:M104	4.32	Yes	No	4	9	7
72	R:R:K86	R:R:P268	6.69	Yes	No	0	9	3
73	R:R:I88	R:R:T100	3.04	No	No	0	5	9
74	R:R:Q89	R:R:T100	12.76	No	No	0	9	9
75	R:R:Q101	R:R:Q89	3.84	No	No	8	6	9
76	R:R:C174	R:R:Q89	7.63	No	No	8	9	9
77	R:R:L96	R:R:S92	3	No	No	0	6	7
78	R:R:L96	R:R:T94	4.42	No	No	0	6	6
79	R:R:C97	R:R:N168	7.87	No	No	0	9	7
80	R:R:C174	R:R:C97	7.28	No	No	0	9	9
81	R:R:C174	R:R:Q101	7.63	No	No	8	9	6
82	R:R:I154	R:R:N102	16.99	No	No	0	6	7
83	R:R:F105	R:R:M109	7.46	No	Yes	0	6	6
84	R:R:F105	R:R:K190	21.09	No	No	0	6	9
85	R:R:F147	R:R:L106	6.09	No	Yes	0	3	7
86	R:R:L106	R:R:V150	2.98	Yes	No	0	7	6
87	R:R:L108	R:R:Y194	3.52	No	No	0	6	5
88	R:R:M109	R:R:V112	3.04	Yes	No	1	6	6
89	R:R:M109	R:R:W113	4.65	Yes	Yes	1	6	5
90	R:R:M109	R:R:V150	6.09	Yes	No	0	6	6
91	R:R:C193	R:R:M109	4.86	No	Yes	0	5	6
92	R:R:M109	R:R:Y194	7.18	Yes	No	0	6	5
93	R:R:C110	R:R:V146	3.42	No	No	0	3	7
94	R:R:C110	R:R:V150	3.42	No	No	0	3	6
95	R:R:V112	R:R:W113	4.9	No	Yes	1	6	5
96	R:R:V112	R:R:W238	12.26	No	Yes	1	6	8
97	R:R:L116	R:R:W113	3.42	No	Yes	0	4	5
98	R:R:W113	R:R:Y142	2.89	Yes	Yes	0	5	7
99	R:R:H115	R:R:M118	3.94	Yes	Yes	1	8	9
100	R:R:C234	R:R:H115	5.9	No	Yes	1	5	8
101	R:R:H115	R:R:W238	6.35	Yes	Yes	1	8	8
102	R:R:H115	R:R:L278	7.71	Yes	Yes	1	8	9
103	R:R:H115	R:R:Y282	6.53	Yes	Yes	1	8	7
104	R:R:G117	R:R:Y142	7.24	No	Yes	0	9	7
105	R:R:M118	R:R:Y282	19.16	Yes	Yes	1	9	7
106	R:R:A119	R:R:L204	3.15	No	No	0	7	3
107	R:R:L120	R:R:L204	4.15	No	No	0	3	3
108	R:R:L204	R:R:T123	8.84	No	No	0	3	7
109	R:R:I207	R:R:T123	3.04	No	No	0	5	7
110	R:R:I208	R:R:T123	6.08	No	No	0	7	7
111	R:R:K211	R:R:L126	8.46	Yes	No	0	9	7
112	R:R:L126	R:R:L212	4.15	No	No	0	7	8
113	R:R:F127	R:R:I207	5.02	No	No	0	3	5
114	R:R:F127	R:R:K211	14.89	No	Yes	0	3	9
115	R:R:K132	R:R:S128	3.06	No	No	0	3	7
116	R:R:P131	R:R:T130	3.5	No	No	0	2	6
117	R:R:N138	R:R:R137	3.62	No	No	0	3	2
118	R:R:L143	R:R:V139	2.98	No	Yes	0	5	8
119	R:R:V146	R:R:Y142	6.31	No	Yes	0	7	7
120	R:R:F147	R:R:L151	9.74	No	No	0	3	4
121	R:R:I154	R:R:L151	2.85	No	No	0	6	4
122	R:R:L157	R:R:V186	4.47	No	No	0	8	5
123	R:R:M161	R:R:M182	5.78	No	No	0	6	4
124	R:R:G162	R:R:P163	4.06	No	No	0	7	3
125	R:R:A165	R:R:L167	3.15	No	Yes	2	6	8
126	R:R:A165	R:R:P178	3.74	No	Yes	2	6	5
127	R:R:N166	R:R:N168	6.81	No	No	0	3	7
128	R:R:G177	R:R:L167	5.13	No	Yes	2	7	8
129	R:R:L167	R:R:P178	3.28	Yes	Yes	2	8	5
130	R:R:M173	R:R:R169	11.17	No	No	0	8	6
131	R:R:R169	R:R:R175	6.4	No	No	0	6	6
132	R:R:G255	R:R:R169	3	No	No	0	5	6
133	R:R:G170	R:R:P171	4.06	No	No	0	4	5
134	R:R:N172	R:R:R265	3.62	No	No	0	8	6
135	R:R:E260	R:R:M173	9.47	Yes	No	0	5	8
136	R:R:P178	R:R:R175	4.32	Yes	No	0	5	6
137	R:R:F256	R:R:R175	17.1	No	No	0	5	6
138	R:R:E176	R:R:H183	6.15	Yes	Yes	10	8	8
139	R:R:E176	R:R:V186	2.85	Yes	No	0	8	5
140	R:R:E176	R:R:Q187	7.65	Yes	Yes	10	8	7
141	R:R:E176	R:R:K190	12.15	Yes	No	0	8	9
142	R:R:G177	R:R:P178	4.06	No	Yes	2	7	5
143	R:R:M182	R:R:T179	3.01	No	No	0	4	8
144	R:R:E250	R:R:K180	4.05	No	No	0	5	2
145	R:R:F256	R:R:K180	19.85	No	No	0	5	2
146	R:R:H183	R:R:Q187	8.65	Yes	Yes	10	8	7
147	R:R:G255	R:R:H183	4.77	No	Yes	0	5	8
148	R:R:F256	R:R:H183	6.79	No	Yes	0	5	8
149	R:R:E250	R:R:T184	7.06	No	No	0	5	6
150	R:R:P244	R:R:Q187	11.05	No	Yes	0	5	7
151	R:R:L254	R:R:Q187	5.32	No	Yes	0	5	7
152	R:R:A191	R:R:L245	4.73	No	Yes	0	6	7
153	R:R:L241	R:R:Y194	10.55	No	No	0	6	5
154	R:R:F239	R:R:L195	4.87	No	No	0	3	6
155	R:R:L195	R:R:S242	9.01	No	No	0	6	6
156	R:R:A198	R:R:F239	5.55	No	No	0	4	3
157	R:R:C234	R:R:I201	6.55	No	No	1	5	6
158	R:R:I201	R:R:W238	8.22	No	Yes	1	6	8
159	R:R:I209	R:R:T205	3.04	Yes	No	0	6	9
160	R:R:G231	R:R:T205	5.46	No	No	0	6	9
161	R:R:I208	R:R:V227	6.14	No	No	0	7	8
162	R:R:I209	R:R:I224	4.42	Yes	No	0	6	4
163	R:R:I209	R:R:V227	3.07	Yes	No	0	6	8
164	R:R:I209	R:R:T228	4.56	Yes	No	0	6	5
165	R:R:K211	R:R:W210	3.48	Yes	No	9	9	3
166	R:R:R214	R:R:W210	8	No	No	9	5	3
167	R:R:K211	R:R:R214	3.71	Yes	No	9	9	5
168	R:R:G218	R:R:L212	3.42	No	No	0	5	8
169	R:R:L213	R:R:R219	3.64	No	No	0	7	4
170	R:R:I224	R:R:L213	4.28	No	No	0	4	7
171	R:R:F217	R:R:T215	9.08	No	No	0	8	9
172	R:R:F217	R:R:G218	4.52	No	No	0	8	5
173	R:R:L223	R:R:R222	4.86	No	No	0	8	5
174	R:R:N226	R:R:T230	2.92	No	Yes	0	8	9
175	R:R:N226	R:R:S285	11.92	No	No	0	8	8
176	R:R:L232	R:R:T228	2.95	No	No	0	5	5
177	R:R:L278	R:R:T230	2.95	Yes	Yes	1	9	9
178	R:R:L281	R:R:T230	4.42	No	Yes	0	7	9
179	R:R:T230	R:R:Y282	7.49	Yes	Yes	1	9	7
180	R:R:I233	R:R:L278	7.14	No	Yes	0	6	9
181	R:R:C234	R:R:W238	13.06	No	Yes	1	5	8
182	R:R:F236	R:R:M240	7.46	No	No	0	4	5
183	R:R:L274	R:R:S237	3	No	No	0	5	6
184	R:R:L243	R:R:P244	4.93	No	No	0	4	5
185	R:R:A251	R:R:S253	3.42	No	No	0	3	3
186	R:R:D257	R:R:T259	4.34	No	No	0	2	7
187	R:R:L262	R:R:T259	4.42	No	No	0	3	7
188	R:R:E260	R:R:R265	13.96	Yes	No	0	5	6
189	R:R:A264	R:R:L262	3.15	No	No	0	6	3
190	R:R:R265	R:R:Y266	13.38	No	Yes	0	6	6
191	R:R:P268	R:R:Y267	23.64	No	No	0	3	5
192	R:R:G269	R:R:P270	4.06	No	No	0	4	5
193	R:R:L278	R:R:Y282	4.69	Yes	Yes	1	9	7
194	R:R:M290	R:R:W284	6.98	No	No	0	5	5
195	R:R:F286	R:R:H288	6.79	Yes	No	1	6	6
196	R:R:F286	R:R:F289	3.22	Yes	No	0	6	7
197	R:R:F289	R:R:L293	7.31	No	No	0	7	8
198	R:R:D291	R:R:S292	2.94	No	No	0	4	7
199	R:R:N295	R:R:V299	2.96	No	No	0	4	5
200	R:R:Q296	R:R:V299	4.3	Yes	No	0	5	5
201	R:R:Q296	R:R:T300	4.25	Yes	No	0	5	9
202	R:R:L72	R:R:M68	2.83	No	Yes	0	9	7
203	R:R:L84	R:R:M87	2.83	No	No	0	4	6
204	R:R:L99	R:R:M103	2.83	No	No	0	4	5
205	R:R:L167	R:R:M161	2.83	Yes	No	0	8	6
206	R:R:L116	R:R:L200	2.77	No	No	0	4	6
207	R:R:L149	R:R:L153	2.77	No	No	0	4	3
208	R:R:L245	R:R:L248	2.77	Yes	No	0	7	6
209	R:R:L158	R:R:N102	2.75	No	No	0	3	7
210	R:R:R62	R:R:S292	2.64	Yes	No	0	7	7
211	R:R:A197	R:R:W238	2.59	No	Yes	0	6	8
212	R:R:A198	R:R:W238	2.59	No	Yes	0	4	8
213	R:R:F60	R:R:I59	2.51	No	No	0	2	3
214	R:R:K220	R:R:R222	2.48	No	No	0	8	5
215	R:R:F35	R:R:L36	2.44	No	No	0	3	8
216	R:R:F217	R:R:L223	2.44	No	No	0	8	8
217	R:R:F236	R:R:L274	2.44	No	No	0	4	5
218	R:R:F247	R:R:L254	2.44	No	No	0	7	5
219	R:R:C97	R:R:G95	1.96	No	No	0	9	5
220	R:R:C148	R:R:G145	1.96	No	No	0	2	4
221	R:R:A251	R:R:G252	1.95	No	No	0	3	4
222	R:R:A191	R:R:P244	1.87	No	No	0	6	5
223	R:R:G38	R:R:S37	1.86	No	Yes	0	4	7
224	R:R:G95	R:R:S92	1.86	No	No	0	5	7
225	R:R:G181	R:R:T179	1.82	No	No	0	1	8
226	R:R:G85	R:R:I88	1.76	No	No	0	6	5
227	R:R:G85	R:R:M104	1.75	No	No	0	6	7
228	R:R:G162	R:R:M161	1.75	No	No	0	7	6
229	R:R:G252	R:R:K180	1.74	No	No	0	4	2
230	R:R:A34	R:R:S37	1.71	No	Yes	0	6	7
231	R:R:G54	R:R:L76	1.71	No	Yes	0	6	4
232	R:R:G107	R:R:L81	1.71	No	No	7	4	5
233	R:R:G107	R:R:L106	1.71	No	Yes	7	4	7
234	R:R:G117	R:R:L120	1.71	No	No	0	9	3
235	R:R:C140	R:R:V139	1.71	No	Yes	0	5	8
236	R:R:G188	R:R:L245	1.71	No	Yes	0	4	7
237	R:R:G192	R:R:L245	1.71	No	Yes	0	3	7
238	R:R:A235	R:R:V202	1.7	No	No	0	7	4
239	R:R:K220	R:R:P221	1.67	No	No	0	8	1
240	R:R:A235	R:R:I201	1.62	No	No	0	7	6
241	R:R:D164	R:R:P163	1.61	No	No	0	3	3
242	R:R:S93	R:R:T94	1.6	No	No	0	4	6
243	R:R:S261	R:R:T259	1.6	No	No	0	5	7
244	R:R:T298	R:R:V297	1.59	No	No	0	4	3
245	R:R:A275	R:R:L79	1.58	No	Yes	0	5	5
246	R:R:I48	R:R:V83	1.54	No	Yes	0	4	5
247	R:R:K63	R:R:V65	1.52	No	No	0	5	4
248	R:R:M182	R:R:T160	1.51	No	No	0	4	4
249	R:R:L42	R:R:S41	1.5	No	No	0	5	4
250	R:R:K132	R:R:T134	1.5	No	No	0	3	4
251	R:R:L195	R:R:V199	1.49	No	No	0	6	4
252	R:R:L80	R:R:T51	1.47	No	No	0	5	6
253	R:R:I155	R:R:I159	1.47	No	No	0	5	4
254	R:R:I48	R:R:M87	1.46	No	No	0	4	6
255	R:R:I88	R:R:M87	1.46	No	No	0	5	6
256	R:R:I208	R:R:K122	1.45	No	No	0	7	8
257	R:R:E260	R:R:S31	1.44	Yes	No	0	5	7
258	R:R:E90	R:R:S37	1.44	No	Yes	0	8	7
259	R:R:I233	R:R:L274	1.43	No	No	0	6	5
260	R:R:I233	R:R:L277	1.43	No	No	0	6	5
261	R:R:K132	R:R:L124	1.41	No	No	0	3	1
262	R:R:C225	R:R:F229	1.4	No	No	0	3	3
263	R:R:H136	R:R:S135	1.39	No	No	0	3	5
264	R:R:L196	R:R:L200	1.38	No	No	0	3	6
265	R:R:F229	R:R:T228	1.3	No	No	0	3	5
266	R:R:R67	R:R:T134	1.29	Yes	No	0	4	4
267	R:R:R129	R:R:T130	1.29	No	No	0	4	6
268	R:R:S285	R:R:W284	1.24	No	No	0	8	5
269	R:R:F60	R:R:L56	1.22	No	No	0	2	5
270	R:R:E90	R:R:F91	1.17	No	No	0	8	5
271	R:R:R302	R:R:Y303	1.03	No	No	0	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:S37	2.2075	4	0	7
2	R:R:R62	7.156	5	1	7
3	R:R:R67	4.5375	4	1	4
4	R:R:M68	5.4375	4	1	7
5	R:R:W71	7.84	5	1	8
6	R:R:L75	5.485	4	1	5
7	R:R:L76	3.6625	4	0	4
8	R:R:L79	2.59	4	0	5
9	R:R:W82	6.134	5	4	7
10	R:R:V83	3.13	5	0	5
11	R:R:K86	5.26	4	4	9
12	R:R:L106	4.08	4	7	7
13	R:R:M109	5.54667	6	1	6
14	R:R:W113	3.965	4	1	5
15	R:R:H115	6.57167	6	1	8
16	R:R:M118	8.372	5	1	9
17	R:R:V139	5.5325	4	0	8
18	R:R:Y142	5.315	4	0	7
19	R:R:L167	3.5975	4	2	8
20	R:R:E176	7.2	4	10	8
21	R:R:P178	3.85	4	2	5
22	R:R:H183	6.59	4	10	8
23	R:R:Q187	8.1675	4	10	7
24	R:R:I209	3.7725	4	0	6
25	R:R:K211	7.635	4	9	9
26	R:R:T230	4.445	4	1	9
27	R:R:W238	7.51167	6	1	8
28	R:R:L245	2.73	4	0	7
29	R:R:E260	7.23	4	0	5
30	R:R:Y266	8.284	5	3	6
31	R:R:L278	5.6225	4	1	9
32	R:R:Y282	8.292	5	1	7
33	R:R:F286	7.70167	6	1	6
34	R:R:Q296	4.025	4	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E260	R:R:R265	29.2681	13.96	Yes	No	0	5	6
2	R:R:R265	R:R:Y266	25.2774	13.38	No	Yes	0	6	6
3	R:R:S37	R:R:Y266	15.0212	3.82	Yes	Yes	0	7	6
4	R:R:E260	R:R:M173	38.9656	9.47	Yes	No	0	5	8
5	R:R:M173	R:R:R169	40.8572	11.17	No	No	0	8	6
6	R:R:G255	R:R:R169	39.4844	3	No	No	0	5	6
7	R:R:G255	R:R:H183	40.9131	4.77	No	Yes	0	5	8
8	R:R:E176	R:R:H183	76.1992	6.15	Yes	Yes	10	8	8
9	R:R:E176	R:R:K190	97.4379	12.15	Yes	No	0	8	9
10	R:R:F105	R:R:K190	98.6751	21.09	No	No	0	6	9
11	R:R:F105	R:R:M109	100	7.46	No	Yes	0	6	6
12	R:R:M109	R:R:Y194	41.8709	7.18	Yes	No	0	6	5
13	R:R:L108	R:R:Y194	39.3168	3.52	No	No	0	6	5
14	R:R:L108	R:R:W82	38.2074	6.83	No	Yes	0	6	7
15	R:R:V83	R:R:W82	22.0049	3.68	Yes	Yes	0	5	7
16	R:R:L47	R:R:V83	15.9709	2.98	No	Yes	0	5	5
17	R:R:C273	R:R:L47	11.4854	3.17	No	No	0	4	5
18	R:R:M109	R:R:V112	50.0599	3.04	Yes	No	1	6	6
19	R:R:V112	R:R:W238	54.6093	12.26	No	Yes	1	6	8
20	R:R:H115	R:R:W238	52.8454	6.35	Yes	Yes	1	8	8
21	R:R:H115	R:R:L75	22.2763	9	Yes	Yes	1	8	5
22	R:R:I279	R:R:L75	51.9275	4.28	No	Yes	0	9	5
23	R:R:I279	R:R:L76	22.2444	5.71	No	Yes	0	9	4
24	R:R:L79	R:R:V83	37.4012	2.98	Yes	Yes	0	5	5
25	R:R:I55	R:R:L76	18.1898	4.28	No	Yes	0	6	4
26	R:R:I55	R:R:I73	13.6882	4.42	No	No	5	6	1
27	R:R:F57	R:R:L293	19.387	4.87	No	No	0	7	8
28	R:R:F289	R:R:L293	22.3881	7.31	No	No	0	7	8
29	R:R:F286	R:R:F289	25.5966	3.22	Yes	No	0	6	7
30	R:R:F286	R:R:M68	53.2365	12.44	Yes	Yes	1	6	7
31	R:R:M118	R:R:M68	46.1888	2.89	Yes	Yes	1	9	7
32	R:R:M118	R:R:W71	48.703	11.63	Yes	Yes	1	9	8
33	R:R:W71	R:R:Y142	50.3791	4.82	Yes	Yes	0	8	7
34	R:R:W113	R:R:Y142	56.2295	2.89	Yes	Yes	0	5	7
35	R:R:M109	R:R:W113	53.3403	4.65	Yes	Yes	1	6	5
36	R:R:H115	R:R:M118	19.4988	3.94	Yes	Yes	1	8	9
37	R:R:M68	R:R:Y282	16.0508	3.59	Yes	Yes	1	7	7
38	R:R:H115	R:R:Y282	22.3482	6.53	Yes	Yes	1	8	7
39	R:R:F57	R:R:Q296	13.1056	4.68	No	Yes	6	7	5
40	R:R:I58	R:R:I73	11.4854	8.83	No	No	0	7	1
41	R:R:F286	R:R:R62	15.8592	3.21	Yes	Yes	1	6	7
42	R:R:R67	R:R:W71	13.6244	3	Yes	Yes	1	4	8
43	R:R:V139	R:R:W71	10.0567	11.03	Yes	Yes	0	8	8
44	R:R:M109	R:R:V150	21.3345	6.09	Yes	No	0	6	6
45	R:R:C110	R:R:V150	11.637	3.42	No	No	0	3	6
46	R:R:L106	R:R:V150	23.2341	2.98	Yes	No	0	7	6
47	R:R:M104	R:R:W82	20.7119	10.47	No	Yes	4	7	7
48	R:R:G85	R:R:M104	19.4509	1.75	No	No	0	6	7
49	R:R:G85	R:R:I88	13.8718	1.76	No	No	0	6	5
50	R:R:I88	R:R:T100	24.0562	3.04	No	No	0	5	9
51	R:R:Q89	R:R:T100	22.1247	12.76	No	No	0	9	9
52	R:R:C174	R:R:Q89	18.1419	7.63	No	No	8	9	9
53	R:R:C174	R:R:C97	16.4019	7.28	No	No	0	9	9
54	R:R:C97	R:R:G95	10.3679	1.96	No	No	0	9	5
55	R:R:F147	R:R:L151	11.7408	9.74	No	No	0	3	4
56	R:R:F147	R:R:L106	14.638	6.09	No	Yes	0	3	7
57	R:R:H115	R:R:L278	18.5569	7.71	Yes	Yes	1	8	9
58	R:R:G117	R:R:Y142	58.3127	7.24	No	Yes	0	9	7
59	R:R:L120	R:R:L204	55.192	4.15	No	No	0	3	3
60	R:R:G117	R:R:L120	56.7883	1.71	No	No	0	9	3
61	R:R:L204	R:R:T123	51.9515	8.84	No	No	0	3	7
62	R:R:I207	R:R:T123	27.592	3.04	No	No	0	5	7
63	R:R:I208	R:R:T123	25.6126	6.08	No	No	0	7	7
64	R:R:F127	R:R:K211	23.8327	14.89	No	Yes	0	3	9
65	R:R:F127	R:R:I207	25.7163	5.02	No	No	0	3	5
66	R:R:K211	R:R:L126	18.094	8.46	Yes	No	0	9	7
67	R:R:L126	R:R:L212	16.1465	4.15	No	No	0	7	8
68	R:R:P178	R:R:R175	25.2774	4.32	Yes	No	0	5	6
69	R:R:L167	R:R:P178	19.0279	3.28	Yes	Yes	2	8	5
70	R:R:L167	R:R:M161	17.1043	2.83	Yes	No	0	8	6
71	R:R:F256	R:R:R175	26.1713	17.1	No	No	0	5	6
72	R:R:F256	R:R:K180	12.922	19.85	No	No	0	5	2
73	R:R:P244	R:R:Q187	15.0212	11.05	No	Yes	0	5	7
74	R:R:A191	R:R:P244	10.8069	1.87	No	No	0	6	5
75	R:R:A198	R:R:W238	10.5276	2.59	No	Yes	0	4	8
76	R:R:I209	R:R:V227	20.0255	3.07	Yes	No	0	6	8
77	R:R:I208	R:R:V227	21.8294	6.14	No	No	0	7	8
78	R:R:G218	R:R:L212	14.1831	3.42	No	No	0	5	8
79	R:R:F217	R:R:G218	12.2037	4.52	No	No	0	8	5
80	R:R:N226	R:R:T230	14.3188	2.92	No	Yes	0	8	9
81	R:R:T230	R:R:Y282	13.6962	7.49	Yes	Yes	1	9	7
82	R:R:N226	R:R:S285	10.7431	11.92	No	No	0	8	8
83	R:R:I233	R:R:L278	13.353	7.14	No	Yes	0	6	9
84	R:R:I48	R:R:V83	18.4612	1.54	No	Yes	0	4	5
85	R:R:I48	R:R:M87	16.4179	1.46	No	No	0	4	6
86	R:R:I279	R:R:L79	35.2861	2.85	No	Yes	0	9	5
87	R:R:L75	R:R:M118	31.463	4.24	Yes	Yes	1	5	9
88	R:R:I88	R:R:M87	12.3633	1.46	No	No	0	5	6
89	R:R:F256	R:R:H183	37.2655	6.79	No	Yes	0	5	8
90	R:R:E176	R:R:Q187	17.5752	7.65	Yes	Yes	10	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7JHJ_nogp

PDB Summary
PDB	7JHJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	251
Number of Links	271
Number of Hubs	34
Number of Links mediated by Hubs	123
Number of Communities	10
Number of Nodes involved in Communities	49
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	91
Number Of Links MetaPath	90
Number of Shortest Paths	33522
Length Of Smallest Path	3
Average Path Length	13.1563
Length of Longest Path	33
Minimum Path Strength	1.305
Average Path Strength	6.36187
Maximum Path Strength	18.475
Minimum Path Correlation	0.7
Average Path Correlation	0.931165
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	50.1536
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.4186
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • protein serine/threonine kinase activity • enzyme regulator activity • catalytic activity, acting on a protein • kinase activity • protein kinase activity • transferase activity • enzyme inhibitor activity • protein kinase regulator activity • phosphotransferase activity, alcohol group as acceptor • transferase activity, transferring phosphorus-containing groups • protein kinase inhibitor activity • molecular function inhibitor activity • molecular function regulator activity • protein serine/threonine kinase inhibitor activity • kinase inhibitor activity • kinase regulator activity • symbiont-mediated perturbation of host defense response • biological process involved in interspecies interaction between organisms • symbiont-mediated perturbation of host immune response • biological process involved in interaction with host • biological process involved in symbiotic interaction • symbiont-mediated suppression of host immune response • symbiont-mediated perturbation of host process • symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I • symbiont-mediated suppression of host antigen processing and presentation • modulation of process of another organism • symbiont-mediated suppression of host adaptive immune response • symbiont-mediated perturbation of host cellular process • response to other organism • symbiont-mediated perturbation of host defenses • symbiont-mediated suppression of host PKR/eIFalpha signaling • symbiont-mediated response to host defenses • response to external stimulus • response to biotic stimulus • symbiont-mediated suppression of host signal transduction pathway • symbiont-mediated suppression of host-directed shutoff of host translation • symbiont-mediated suppression of host defenses • response to host • response to external biotic stimulus • symbiont-mediated perturbation of host signal transduction pathway • symbiont-mediated suppression of host innate immune response • symbiont-mediated perturbation of host innate immune response • symbiont-mediated suppression of host interferon-mediated signaling pathway • symbiont-mediated suppression of host type I interferon-mediated signaling pathway • positive regulation of response to biotic stimulus • pattern recognition receptor signaling pathway • regulation of NLRP3 inflammasome complex assembly • negative regulation of biological process • regulation of signal transduction • cellular component biogenesis • immune response-activating signaling pathway • cellular component assembly • inflammasome-mediated signaling pathway • positive regulation of immune response • canonical inflammasome complex assembly • regulation of immune system process • negative regulation of NLRP3 inflammasome complex assembly • positive regulation of immune system process • innate immune response-activating signaling pathway • negative regulation of cellular component organization • immune response • regulation of innate immune response • regulation of inflammasome-mediated signaling pathway • negative regulation of protein-containing complex assembly • regulation of response to stimulus • defense response to other organism • regulation of pattern recognition receptor signaling pathway • NLRP3 inflammasome complex assembly • positive regulation of defense response • activation of innate immune response • regulation of immune response • inflammatory response • activation of immune response • cytoplasmic pattern recognition receptor signaling pathway • regulation of defense response • regulation of response to biotic stimulus • regulation of cellular component organization • regulation of response to external stimulus • intracellular receptor signaling pathway • negative regulation of signaling • negative regulation of cytoplasmic pattern recognition receptor signaling pathway • negative regulation of intracellular signal transduction • positive regulation of biological process • regulation of cytoplasmic pattern recognition receptor signaling pathway • negative regulation of cell communication • positive regulation of response to stimulus • cellular component organization • regulation of protein-containing complex assembly • positive regulation of response to external stimulus • immune response-regulating signaling pathway • regulation of intracellular signal transduction • regulation of response to stress • response to stress • innate immune response • negative regulation of cellular process • protein-containing complex assembly • cellular component organization or biogenesis • regulation of signaling • positive regulation of innate immune response • defense response • negative regulation of response to stimulus • protein-containing complex organization • defense response to symbiont • regulation of cellular component biogenesis • negative regulation of signal transduction • negative regulation of immune system process • immune system process • regulation of cell communication • negative regulation of inflammasome-mediated signaling pathway • host cellular component • host intracellular membrane-bounded organelle • host intracellular part • host cell membrane • host cell mitochondrion • host cell cytoplasm part • host intracellular organelle • host organelle outer membrane • host cell cytoplasm • host cell part • host cell mitochondrial envelope • host intracellular region • host cell mitochondrial outer membrane • host cell mitochondrial membrane • host outer membrane • mitochondrial membrane • mitochondrion • organelle outer membrane • organelle envelope • mitochondrial envelope • mitochondrial outer membrane • outer membrane • host cell plasma membrane
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q3KSP2
Sequence	>7JHJ_nogp_Chain_R C T K S Y S A F L S G M T S L L L V L L I L L T L A G I L F I I F V R K L V H R M D V W L I A L L I E L L L W V L G K M I Q E F S S T G L C L L T Q N M M F L G L M C S V W T H L G M A L E K T L A L F S R T P K R T S H R N V C L Y L M G V F C L V L L L I I I L L I T M G P D A N L N R G P N M C R E G P T K G M H T A V Q G L K A G C Y L L A A V L I V L L T V I I I W K L L R T K F G R K P R L I C N V T F T G L I C A F S W F M L S L P L L F L G E A G S L G F D C T E S L V A R Y Y P G P A A C L A L L L I I L Y A W S F S H F M D S L K N Q V T V T A R Y F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7JHJ	A	Other	Unclassified	BILF1	Human gammaherpesvirus 4	-	-	Gi1/β1/γ2	3.2	2021-07-07	10.1016/j.immuni.2021.06.001
	7JHJ (No Gprot)	A	Other	Unclassified	BILF1	Human gammaherpesvirus 4	-	-		3.2	2021-07-07	10.1016/j.immuni.2021.06.001

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