Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:N58 6.5225119
2A:A:Y209 4.8875407
3A:A:F211 7.785478
4A:A:I213 4.1725475
5A:A:V216 4.1575474
6A:A:F218 5.066577
7A:A:R227 3.794179
8A:A:E229 7.5625439
9A:A:W233 5.66409
10A:A:F237 4.235409
11A:A:D248 10.58754118
12A:A:S250 4.51254119
13A:A:F252 5.15509
14A:A:F272 7.91469
15A:A:I275 4.03754178
16A:A:I286 4.0775467
17A:A:I287 3.1654139
18A:A:L288 3.465469
19A:A:F289 6.1325139
20A:A:L296 3.18408
21A:A:I305 4.0765186
22A:A:F309 4.68254189
23A:A:F312 4.72754185
24A:A:D315 4.38754153
25A:A:F325 6.3085186
26A:A:F330 6.328568
27A:A:K340 4.1056147
28A:A:Y343 9.85409
29A:A:F346 7.555405
30A:A:F359 6.555479
31A:A:T365 4.93254146
32A:A:M375 5.33754196
33B:B:D27 7.1225408
34B:B:I37 3.286502
35B:B:V40 4.185403
36B:B:M45 3.0175494
37B:B:H54 6.31333619
38B:B:L55 3.894516
39B:B:W63 6.3875417
40B:B:V71 2.9975408
41B:B:W82 9.29619
42B:B:S84 3.73415
43B:B:K89 5.158519
44B:B:H91 4.7845165
45B:B:I93 4.364167
46B:B:W99 4.832509
47B:B:Y105 3.33506
48B:B:Y111 6.405404
49B:B:L117 3.4875409
50B:B:D118 4.09754229
51B:B:C121 3.2825438
52B:B:I123 3.26754236
53B:B:Y124 4.327166
54B:B:V133 4.95754164
55B:B:L139 5.375409
56B:B:H142 6.29167639
57B:B:Y145 5.092538
58B:B:F151 3.335409
59B:B:L152 4.245403
60B:B:T159 5.745439
61B:B:S161 6.72439
62B:B:D163 9.42439
63B:B:W169 6.99333638
64B:B:F180 6.458547
65B:B:H183 7.16833649
66B:B:D186 4.74439
67B:B:L190 3.346545
68B:B:F199 5.898549
69B:B:V200 4.5725426
70B:B:D205 6.235449
71B:B:K209 8.595446
72B:B:W211 8.144548
73B:B:D212 6.2409
74B:B:C218 4.5025445
75B:B:F222 6.41428
76B:B:H225 5.91429729
77B:B:I232 5.0975428
78B:B:F235 6.85246
79B:B:F241 4.84667626
80B:B:T243 3.912528
81B:B:D247 7.32429
82B:B:T249 5.6675426
83B:B:R251 8.922528
84B:B:F253 6.23526
85B:B:D258 6.54427
86B:B:M262 5.654204
87B:B:Y264 5.183336205
88B:B:F278 5.28407
89B:B:R283 7.875409
90B:B:Y289 5.605717257
91B:B:D290 8.215406
92B:B:D298 8.88754219
93B:B:H311 8.056599
94B:B:M325 5.095405
95B:B:W332 12.4875409
96B:B:D333 6.68499
97B:B:L336 4.6775417
98B:B:K337 6.346596
99B:B:W339 8.656599
100B:B:N340 5.115419
101G:G:L19 2.4825409
102G:G:D48 6.654509
103G:G:L51 5.335406
104G:G:F61 4.74429718
105R:R:Y384 4.29408
106R:R:F385 5.665409
107R:R:V390 1.4475406
108R:R:H399 5.265407
109R:R:G410 4.114279
110R:R:Y425 7.785456
111R:R:Y441 9.0825455
112R:R:T442 4.9725456
113R:R:I443 4.5975456
114R:R:F454 3.8575407
115R:R:H483 6.39714789
116R:R:S485 3.71254297
117R:R:L487 5.3825489
118R:R:T488 4.83254127
119R:R:W492 8.148336129
120R:R:R502 6.812558
121R:R:L503 5.9725408
122R:R:F508 4.73571779
123R:R:Y511 7.504519
124R:R:P513 3.2175405
125R:R:Y515 9.95167658
126R:R:W524 7.5045129
127R:R:Y542 6.278589
128R:R:M561 4.6675487
129R:R:W563 7.86833689
130R:R:V569 3.4325408
131R:R:T573 3.9975487
132R:R:N574 4.148588
133R:R:F578 4.265107
134R:R:N585 6.0325409
135R:R:M592 4.05167609
136R:R:W623 6.9385109
137R:R:Y641 4.5375408
138R:R:F643 5.9885109
139R:R:T647 7.63254109
140R:R:F655 4.62754288
141R:R:W659 6.42754285
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L70 B:B:W82 97.40975.69NoYes159
2B:B:L70 B:B:S84 52.01273NoYes155
3B:B:S84 G:G:F61 51.75962.64YesYes158
4A:A:E41 B:B:K78 29.76576.75NoNo058
5A:A:E41 B:B:L55 29.84882.65NoYes056
6B:B:D76 B:B:L55 99.01396.79NoYes196
7B:B:D76 B:B:H54 98.84742.52NoYes199
8B:B:H54 B:B:S72 49.22195.58YesNo199
9B:B:S72 B:B:W82 48.90786.18NoYes199
10B:B:H54 B:B:I80 49.28799.28YesNo198
11B:B:I80 B:B:W82 48.907715.27NoYes189
12A:A:K42 B:B:L55 54.17984.23NoYes156
13A:A:K46 B:B:L55 54.17982.82NoYes146
14A:A:K42 R:R:Y511 54.17147.17NoYes159
15A:A:K46 R:R:Y511 54.171515.53NoYes149
16A:A:V216 R:R:F508 51.09333.93YesYes749
17A:A:I366 R:R:F508 82.1563.77NoYes789
18A:A:I366 A:A:N370 82.62044.25NoNo088
19A:A:N370 R:R:L503 41.67028.24NoYes088
20R:R:L503 R:R:R502 45.76126.07YesYes088
21R:R:R502 R:R:Y441 85.55744.12YesYes585
22R:R:R439 R:R:Y441 99.951410.29NoYes065
23R:R:R439 R:R:Y511 1008.23NoYes069
24A:A:N370 R:R:T510 41.10494.39NoNo086
25R:R:R502 R:R:T510 41.17362.59YesNo086
26A:A:F218 A:A:V216 50.03525.24YesYes774
27B:B:K57 B:B:W332 61.304124.37NoYes099
28B:B:R314 B:B:W332 63.144114.99NoYes089
29B:B:D290 B:B:R314 63.406719.06YesNo068
30B:B:C271 B:B:D290 64.19464.67NoYes056
31B:B:C271 B:B:Y289 64.44222.69NoYes2557
32B:B:W297 B:B:Y289 66.76673.86NoYes087
33B:B:W297 B:B:Y264 68.62556.75NoYes085
34B:B:M262 B:B:Y264 80.133210.78YesYes2045
35B:B:L30 B:B:M262 81.95887.07NoYes054
36B:B:L30 B:B:T34 82.21852.95NoNo055
37B:B:I37 B:B:T34 82.73793.04YesNo025
38B:B:I37 B:B:R283 84.0036.26YesYes029
39B:B:R283 G:G:L51 85.55156.07YesYes096
40G:G:D48 G:G:L51 87.40488.14YesYes096
41G:G:D48 G:G:P49 88.43363.22YesNo097
42B:B:M325 G:G:P49 88.94796.71YesNo057
43A:A:F218 A:A:I51 17.26822.51YesNo077
44A:A:F211 A:A:F218 30.41058.57YesYes787
45A:A:F211 A:A:I213 30.39985.02YesYes785
46A:A:F359 A:A:I213 30.71196.28YesYes795
47A:A:F359 R:R:F508 31.47868.57YesYes799
48A:A:I51 A:A:S242 16.48173.1NoNo078
49B:B:Q75 B:B:W99 58.14522.19NoYes099
50B:B:Q75 B:B:Y59 58.408716.91NoNo098
51B:B:K57 B:B:Y59 58.67212.39NoNo098
52A:A:F211 A:A:I70 59.231413.82YesNo088
53A:A:I287 A:A:S242 14.91423.1YesNo098
54B:B:L117 B:B:W99 51.20844.56YesYes099
55A:A:K292 A:A:N291 66.60641.4NoNo099
56A:A:L246 A:A:N291 26.95026.87NoNo079
57A:A:F64 A:A:L246 27.88773.65NoNo077
58A:A:F64 A:A:M68 28.19246.22NoNo079
59A:A:I70 A:A:M68 56.06417.29NoNo089
60A:A:N291 A:A:T347 40.45352.92NoNo099
61A:A:N354 A:A:T347 27.24325.85NoNo1399
62A:A:M68 A:A:N354 27.56062.8NoNo099
63A:A:F289 A:A:T347 13.684410.38YesNo1399
64A:A:F289 A:A:I287 14.13632.51YesYes1399
65A:A:K292 A:A:S250 60.26456.12NoYes1199
66B:B:L117 B:B:Y145 47.50573.52YesYes098
67A:A:L288 A:A:L290 17.47042.77YesNo099
68A:A:F346 A:A:L290 18.2647.31YesNo059
69A:A:F346 A:A:Q323 23.821316.4YesNo055
70A:A:L319 A:A:Q323 24.61476.65NoNo035
71A:A:L296 A:A:L319 26.99472.77YesNo083
72A:A:L296 A:A:S250 52.3581.5YesYes089
73A:A:F330 A:A:L288 11.11923.65YesYes689
74A:A:F252 A:A:L296 23.82132.44YesYes098
75A:A:F252 A:A:I305 18.26638.79YesYes096
76B:B:K78 B:B:P94 29.59943.35NoNo085
77B:B:I93 B:B:P94 29.51623.39YesNo075
78B:B:I93 B:B:L79 14.31224.28YesNo077
79B:B:L79 B:B:V71 14.13882.98NoYes078
80B:B:V71 B:B:Y105 13.80032.52YesYes086
81B:B:H62 B:B:Y105 27.08594.36NoYes066
82B:B:H62 B:B:R150 26.908416.93NoNo066
83B:B:L190 B:B:R150 24.92752.43YesNo056
84B:B:F199 B:B:L190 22.58473.65YesYes495
85B:B:F199 B:B:W211 21.173812.03YesYes498
86B:B:S201 B:B:W211 20.11474.94NoYes098
87B:B:G202 B:B:S201 19.96031.86NoNo069
88B:B:G202 B:B:I229 19.7813.53NoNo067
89B:B:I229 B:B:T243 17.60534.56NoYes278
90B:B:I93 B:B:Y124 14.5823.63YesYes1676
91B:B:V112 B:B:Y124 13.89053.79NoYes086
92B:B:V112 B:B:Y105 13.81912.52NoYes086
93B:B:N340 G:G:F61 45.21263.62YesYes198
94B:B:D323 B:B:M325 44.53564.16NoYes075
95B:B:D323 B:B:T321 44.64347.23NoNo177
96B:B:T321 B:B:W63 45.032410.92NoYes177
97B:B:G162 B:B:Y145 41.63565.79NoYes398
98B:B:G162 B:B:S161 41.40653.71NoYes399
99B:B:H142 B:B:S161 38.728913.95YesYes399
100B:B:H142 B:B:T159 18.29555.48YesYes399
101B:B:T159 B:B:W169 11.57359.7YesYes398
102B:B:I157 B:B:W169 11.30783.52NoYes078
103B:B:F151 B:B:I157 10.76912.51YesNo097
104B:B:A167 B:B:H142 12.37622.93NoYes349
105B:B:A167 B:B:W169 11.56973.89NoYes348
106B:B:C121 B:B:L139 10.23684.76YesYes089
107B:B:L139 B:B:R137 18.30653.64YesNo095
108B:B:I123 B:B:R137 16.15342.51YesNo2365
109B:B:I123 B:B:Y111 22.6123.63YesYes064
110B:B:L139 B:B:W169 10.230611.39YesYes098
111B:B:N125 B:B:Y111 12.92218.14NoYes044
112R:R:L519 R:R:Y515 16.25558.21NoYes088
113R:R:L495 R:R:L519 16.08342.77NoNo088
114R:R:L495 R:R:W492 15.91217.97NoYes089
115R:R:W492 R:R:W524 14.757114.06YesYes1299
116R:R:T488 R:R:W524 13.90467.28YesYes1279
117R:R:P527 R:R:T488 12.86173.5NoYes1297
118R:R:F526 R:R:P527 12.70822.89NoNo049
119R:R:F526 R:R:L530 12.53776.09NoNo045
120R:R:L487 R:R:L530 12.36795.54YesNo095
121B:B:L70 B:B:W63 45.28024.56NoYes157
122B:B:M325 B:B:N340 44.60382.8YesYes059
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7SF8
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRG1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi2-G13)/Beta1/Gamma2
PDB Resolution 2.7
Date 2022-04-27
D.O.I. doi.org/10.1038/s41586-022-04575-7
Net Summary
Imin 2.48
Number of Linked Nodes 814
Number of Links 955
Number of Hubs 141
Number of Links mediated by Hubs 524
Number of Communities 30
Number of Nodes involved in Communities 204
Number of Links involved in Communities 269
Path Summary
Number Of Nodes in MetaPath 123
Number Of Links MetaPath 122
Number of Shortest Paths 6103075
Length Of Smallest Path 3
Average Path Length 47.8959
Length of Longest Path 77
Minimum Path Strength 1.235
Average Path Strength 6.10524
Maximum Path Strength 19.68
Minimum Path Correlation 0.7
Average Path Correlation 0.993913
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.81818
Average % Of Corr. Nodes 31.6187
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.2563
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • signaling receptor binding   • G protein-coupled receptor binding   • D5 dopamine receptor binding   • dopamine receptor binding   • GTPase regulator activity   • enzyme regulator activity   • guanyl-nucleotide exchange factor activity   • nucleoside-triphosphatase regulator activity   • molecular function regulator activity   • G-protein beta/gamma-subunit complex binding   • G protein activity   • cation binding   • metal ion binding   • circulatory system process   • regulation of blood pressure   • regulation of biological quality   • blood circulation   • cellular developmental process   • cell differentiation   • regulation of cell motility   • regulation of fibroblast migration   • fibroblast migration   • regulation of locomotion   • ameboidal-type cell migration   • regulation of cell migration   • cell migration   • cell motility   • locomotion   • embryo development ending in birth or egg hatching   • chordate embryonic development   • embryo development   • in utero embryonic development   • regulation of developmental process   • regulation of cell shape   • cell morphogenesis   • regulation of cell morphogenesis   • anatomical structure morphogenesis   • regulation of anatomical structure morphogenesis   • regulation of body fluid levels   • wound healing   • cell activation   • hemostasis   • blood coagulation   • response to stress   • coagulation   • response to wounding   • platelet activation   • branching morphogenesis of an epithelial tube   • angiogenesis   • tube morphogenesis   • epithelial tube morphogenesis   • blood vessel development   • epithelium development   • blood vessel morphogenesis   • tube development   • morphogenesis of an epithelium   • tissue development   • vasculature development   • circulatory system development   • branching involved in blood vessel morphogenesis   • tissue morphogenesis   • morphogenesis of a branching structure   • anatomical structure formation involved in morphogenesis   • morphogenesis of a branching epithelium   • regulation of cellular component organization   • cellular component organization   • cellular component biogenesis   • cellular component assembly   • regulation of postsynapse assembly   • cell junction assembly   • regulation of synapse structure or activity   • synapse organization   • cellular component organization or biogenesis   • regulation of synapse assembly   • postsynapse organization   • postsynapse assembly   • regulation of postsynapse organization   • nervous system development   • regulation of cellular component biogenesis   • regulation of cell junction assembly   • regulation of synapse organization   • cell junction organization   • synapse assembly   • Rho-activating G protein-coupled receptor signaling pathway   • regulation of signaling   • regulation of small GTPase mediated signal transduction   • regulation of signal transduction   • regulation of intracellular signal transduction   • regulation of response to stimulus   • regulation of cell communication   • Rho protein signal transduction   • anchoring junction   • focal adhesion   • cell-substrate junction   • pigment granule   • intracellular vesicle   • melanosome   • cytoplasmic vesicle   • brush border membrane   • cluster of actin-based cell projections   • brush border   • apical part of cell   • plasma membrane region   • apical plasma membrane   • cell projection membrane   • postsynapse   • nucleus   • extracellular matrix binding   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • collagen binding   • heparin binding   • glycosaminoglycan binding   • sulfur compound binding   • reproductive system development   • gonad development   • reproductive process   • sex differentiation   • developmental process involved in reproduction   • male gonad development   • male sex differentiation   • development of primary male sexual characteristics   • development of primary sexual characteristics   • seminiferous tubule development   • reproductive structure development   • positive regulation of cell population proliferation   • positive regulation of biological process   • positive regulation of neural precursor cell proliferation   • regulation of cell population proliferation   • neural precursor cell proliferation   • positive regulation of cellular process   • regulation of neural precursor cell proliferation   • head development   • central nervous system development   • brain development   • forebrain development   • glial cell migration   • telencephalon glial cell migration   • cerebral cortex development   • neurogenesis   • telencephalon cell migration   • forebrain cell migration   • gliogenesis   • layer formation in cerebral cortex   • cerebral cortex cell migration   • cerebral cortex radially oriented cell migration   • pallium development   • cerebral cortex radial glia-guided migration   • telencephalon development   • positive regulation of cell communication   • positive regulation of signal transduction   • positive regulation of response to stimulus   • positive regulation of intracellular signal transduction   • regulation of Rho protein signal transduction   • positive regulation of Rho protein signal transduction   • positive regulation of small GTPase mediated signal transduction   • positive regulation of signaling   • cellular response to growth factor stimulus   • cell surface receptor protein tyrosine kinase signaling pathway   • regulation of vascular endothelial growth factor signaling pathway   • enzyme-linked receptor protein signaling pathway   • regulation of cellular response to vascular endothelial growth factor stimulus   • cell surface receptor signaling pathway   • regulation of cellular response to growth factor stimulus   • positive regulation of vascular endothelial growth factor signaling pathway   • vascular endothelial growth factor signaling pathway   • cellular response to vascular endothelial growth factor stimulus   • response to growth factor   • negative regulation of ferroptosis   • negative regulation of programmed cell death   • negative regulation of biological process   • regulation of programmed cell death   • cell death   • negative regulation of cellular process   • regulation of ferroptosis   • ferroptosis   • programmed cell death   • cell adhesion   • positive regulation of cell adhesion   • regulation of cell adhesion   • negative regulation of cell population proliferation   • multicellular organismal-level homeostasis   • homeostatic process   • hematopoietic stem cell homeostasis   • homeostasis of number of cells   • homotypic cell-cell adhesion   • regulation of cell activation   • cell-cell adhesion   • regulation of cell-cell adhesion   • regulation of multicellular organismal process   • regulation of homotypic cell-cell adhesion   • platelet aggregation   • regulation of platelet activation   • regulation of platelet aggregation   • telencephalon regionalization   • pattern specification process   • cerebral cortex regionalization   • regionalization   • forebrain regionalization   • negative regulation of locomotion   • negative regulation of neuron migration   • regulation of neuron migration   • negative regulation of cell migration   • neuron migration   • generation of neurons   • negative regulation of cell motility   • membrane microdomain   • membrane raft   • glial cell projection   • glial limiting end-foot   • astrocyte end-foot   • astrocyte projection
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtQ14344
Sequence
>7SF8_Chain_A
EDKAAAERS KEIDKCLSR EKTYVKRLV KILLLGADN SGKSTFLKQ 
MRIKGIHEY DFEIKNVPF KMVDVGGQR SERKRWFEC FDSVTSILF 
LVDSSDFNR LTESLNDFE TIVNNRVFS NVSIILFLN KTDLLEEKV 
QIVSIKDYF LEFEGDPHC LRDVQKFLV ECFRNKRRD QQQKPLYHH 
FTTAINTEN ARLIFRDVK DTILHDNLK QLMLQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7SF8_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7SF8_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ9Y653
Sequence
>7SF8_Chain_R
TYFAVLMVS SVEVDAVHK HYLSLLSYV GCVVSALAC LVTIAAYLC 
SRRKPRDYT IKVHMNLLL AVFLLDTSF LLSEPVALT GSEAGCRAS 
AIFLHFSLL TCLSWMGLE GYNLYRLVV EVFGTYVPG YLLKLSAMG 
WGFPIFLVT LVALVDVDN YGPIILASM CWIRDSLVS YITNLGLFS 
LVFLFNMAM LATMVVQIL RWSHVLTLL GLSLVLGLP WALIFFSFA 
SGTFQLVVL YLFSIITSF QGFLIFIWY WSMRL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7SF8B2AdhesionAdhesionADGRG1Homo sapiens--chim(NtGi2-G13)/β1/γ22.72022-04-27doi.org/10.1038/s41586-022-04575-7
7SF8 (No Gprot) B2AdhesionAdhesionADGRG1Homo sapiens--2.72022-04-27doi.org/10.1038/s41586-022-04575-7




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