Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Y384 4.29408
2R:R:F385 5.665409
3R:R:V390 1.4475406
4R:R:H399 5.265407
5R:R:G410 4.114219
6R:R:Y425 7.785446
7R:R:Y441 9.0825445
8R:R:T442 4.9725446
9R:R:I443 4.5975446
10R:R:F454 3.8575407
11R:R:H483 6.39714779
12R:R:S485 3.71254187
13R:R:L487 5.3825479
14R:R:T488 4.83254117
15R:R:W492 7.337147119
16R:R:R502 6.812548
17R:R:L503 5.9725408
18R:R:F508 4.73571799
19R:R:Y511 7.092519
20R:R:P513 3.2175405
21R:R:Y515 9.95167648
22R:R:W524 7.5045119
23R:R:Y542 6.278579
24R:R:M561 4.6675477
25R:R:W563 7.86833679
26R:R:V569 3.4325408
27R:R:T573 3.9975477
28R:R:N574 4.148578
29R:R:F578 4.26587
30R:R:F582 5.86487
31R:R:N585 6.0325409
32R:R:M592 4.05167609
33R:R:L621 3.0775487
34R:R:W623 6.938589
35R:R:Y641 4.5375408
36R:R:F643 5.988589
37R:R:T647 7.6325489
38R:R:F655 4.62754228
39R:R:W657 4.8575409
40R:R:W659 6.42754225
41A:A:N58 6.5225129
42A:A:F64 4.295407
43A:A:Y209 4.8875407
44A:A:F211 7.785498
45A:A:I213 4.1725495
46A:A:V216 4.1575494
47A:A:F218 5.066597
48A:A:R227 3.794199
49A:A:E229 7.5625439
50A:A:F237 4.235409
51A:A:L244 3.27254158
52A:A:D248 10.58754128
53A:A:S250 4.51254129
54A:A:F252 5.15509
55A:A:F272 7.91469
56A:A:I275 4.03754198
57A:A:I286 4.0775467
58A:A:I287 3.1654159
59A:A:L288 3.465469
60A:A:F289 6.1325159
61A:A:L296 3.18408
62A:A:I305 4.0765206
63A:A:F309 4.68254209
64A:A:F312 4.72754205
65A:A:D315 4.38754163
66A:A:F325 6.3085206
67A:A:F330 6.328568
68A:A:K340 4.1056147
69A:A:Y343 9.85409
70A:A:F346 7.555405
71A:A:F359 6.555499
72A:A:T365 4.93254146
73A:A:M375 5.33754136
74A:A:Q377 4.10254139
75B:B:D27 7.1225408
76B:B:I37 3.286502
77B:B:V40 4.185403
78B:B:M45 3.01754104
79B:B:H54 6.31333619
80B:B:L55 3.894516
81B:B:W63 6.3875417
82B:B:V71 2.9975408
83B:B:W82 9.29619
84B:B:S84 3.73415
85B:B:K89 5.158519
86B:B:H91 4.7845175
87B:B:I93 4.364177
88B:B:W99 4.832509
89B:B:Y105 3.33506
90B:B:Y111 6.405404
91B:B:G115 1.89254279
92B:B:L117 3.278509
93B:B:D118 4.09754279
94B:B:C121 3.2825438
95B:B:I123 3.26754286
96B:B:Y124 4.327176
97B:B:V133 4.95754174
98B:B:L139 5.375409
99B:B:H142 5.74572739
100B:B:Y145 5.092538
101B:B:F151 3.335409
102B:B:L152 4.245403
103B:B:T159 5.745439
104B:B:S161 6.72439
105B:B:D163 9.42439
106B:B:W169 6.99333638
107B:B:Q176 5.475434
108B:B:F180 6.458557
109B:B:H183 7.16833659
110B:B:D186 4.74439
111B:B:L190 3.346555
112B:B:A193 1.94404
113B:B:F199 5.898559
114B:B:V200 4.5725426
115B:B:D205 6.235459
116B:B:K209 8.595456
117B:B:W211 8.144558
118B:B:C218 4.5025455
119B:B:F222 5.616528
120B:B:H225 5.91429729
121B:B:I232 5.0975428
122B:B:F235 6.85296
123B:B:F241 4.50286726
124B:B:T243 3.912528
125B:B:D247 7.32429
126B:B:T249 5.6675426
127B:B:R251 8.922528
128B:B:F253 6.23526
129B:B:D258 6.54427
130B:B:M262 5.654254
131B:B:Y264 5.183336255
132B:B:F278 5.28407
133B:B:R283 7.875409
134B:B:Y289 5.605717307
135B:B:D290 8.215406
136B:B:D298 8.88754269
137B:B:H311 8.0565109
138B:B:M325 5.095405
139B:B:W332 12.4875409
140B:B:L336 4.6775417
141B:B:K337 6.3465106
142B:B:W339 8.6565109
143B:B:N340 5.115419
144G:G:L19 2.4825409
145G:G:D48 6.654509
146G:G:L51 5.335406
147G:G:F61 4.74429718
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:T488 R:R:W524 11.89997.28YesYes1179
2R:R:P527 R:R:T488 10.49183.5NoYes1197
3R:R:F526 R:R:P527 10.34682.89NoNo049
4R:R:F526 R:R:L530 10.17516.09NoNo045
5R:R:L487 R:R:L530 10.00445.54YesNo095
6R:R:Y441 R:R:Y515 11.502214.89YesYes458
7R:R:L519 R:R:Y515 14.23218.21NoYes088
8R:R:L495 R:R:L519 14.05862.77NoNo088
9R:R:L495 R:R:W492 13.88717.97NoYes089
10R:R:W492 R:R:W524 12.584114.06YesYes1199
11R:R:R439 R:R:Y441 99.959210.29NoYes065
12R:R:R439 R:R:Y511 1006.17NoYes069
13R:R:V512 R:R:Y515 11.639911.36NoYes068
14R:R:P513 R:R:V512 11.68243.53YesNo056
15R:R:P513 R:R:Y511 11.85285.56YesYes059
16R:R:H446 R:R:T442 15.2435.48NoYes496
17R:R:H446 R:R:V618 14.73552.77NoNo499
18R:R:V618 R:R:W657 14.55772.45NoYes099
19R:R:G614 R:R:W657 14.46879.85NoYes099
20R:R:G614 R:R:L613 14.2341.71NoNo097
21R:R:L613 R:R:S616 13.76751.5NoNo079
22R:R:L621 R:R:S616 13.53451.5YesNo079
23R:R:F582 R:R:L621 12.22472.44YesYes877
24R:R:F578 R:R:F582 11.75795.36YesYes877
25R:R:F578 R:R:W623 10.13164.01YesYes879
26R:R:N499 R:R:Y515 10.54625.81NoYes498
27R:R:L503 R:R:R502 42.25016.07YesYes088
28R:R:R502 R:R:T510 40.15092.59YesNo086
29A:A:N370 R:R:L503 40.74848.24NoYes088
30A:A:N370 R:R:T510 40.08474.39NoNo086
31A:A:I366 R:R:F508 80.22633.77NoYes989
32A:A:I366 A:A:N370 80.68534.25NoNo088
33A:A:V216 R:R:F508 50.05913.93YesYes949
34A:A:F359 R:R:F508 30.81768.57YesYes999
35A:A:K42 R:R:Y511 55.96197.17NoYes159
36A:A:K46 R:R:Y511 55.96215.53NoYes149
37A:A:I51 A:A:S242 16.14793.1NoNo078
38A:A:F218 A:A:I51 16.92572.51YesNo077
39A:A:F218 A:A:V216 49.02275.24YesYes974
40B:B:S84 G:G:F61 25.51862.64YesYes158
41B:B:L70 B:B:S84 25.8763NoYes155
42B:B:L70 B:B:W82 43.19785.69NoYes159
43B:B:S72 B:B:W82 21.94896.18NoYes199
44B:B:H54 B:B:S72 22.41775.58YesNo199
45B:B:D76 B:B:H54 45.55032.52NoYes199
46B:B:D76 B:B:L55 45.82986.79NoYes196
47A:A:K42 B:B:L55 55.96164.23NoYes156
48B:B:I80 B:B:W82 21.948815.27NoYes189
49B:B:H54 B:B:I80 22.51969.28YesNo198
50A:A:K46 B:B:L55 55.96162.82NoYes146
51A:A:E41 B:B:K78 73.25816.75NoNo058
52A:A:E41 B:B:L55 73.32342.65NoYes056
53B:B:L117 B:B:W99 14.36064.56YesYes099
54B:B:L117 B:B:Y145 20.78763.52YesYes098
55B:B:G162 B:B:Y145 27.58585.79NoYes398
56B:B:G162 B:B:S161 35.10693.71NoYes399
57B:B:H142 B:B:S161 36.376513.95YesYes399
58B:B:H142 B:B:L146 19.31962.57YesNo397
59B:B:C121 B:B:L146 19.48183.17YesNo387
60B:B:C121 B:B:C149 46.98091.82YesNo088
61B:B:C149 B:B:T102 47.2995.07NoNo088
62B:B:G115 B:B:T102 47.45961.82YesNo098
63B:B:C114 B:B:G115 48.74691.96NoYes089
64B:B:C114 B:B:L79 24.40733.17NoNo087
65B:B:I93 B:B:L79 36.12254.28YesNo077
66B:B:I93 B:B:P94 73.0663.39YesNo075
67B:B:K78 B:B:P94 73.12843.35NoNo085
68B:B:H142 B:B:T159 19.5395.48YesYes399
69B:B:C121 B:B:T159 21.48253.38YesYes389
70B:B:C114 B:B:Y124 24.5025.38NoYes086
71B:B:I93 B:B:Y124 36.36963.63YesYes1776
72A:A:F211 A:A:F218 29.76858.57YesYes987
73A:A:F211 A:A:I213 29.75655.02YesYes985
74A:A:F359 A:A:I213 30.06446.28YesYes995
75A:A:F211 A:A:I70 57.963713.82YesNo088
76A:A:I287 A:A:S242 14.60293.1YesNo098
77A:A:K292 A:A:N291 65.12781.4NoNo099
78A:A:L246 A:A:N291 26.35446.87NoNo079
79A:A:F64 A:A:L246 27.28533.65YesNo077
80A:A:F64 A:A:M68 27.57496.22YesNo079
81A:A:I70 A:A:M68 54.83217.29NoNo089
82A:A:N291 A:A:T347 39.55732.92NoNo099
83A:A:N354 A:A:T347 26.63625.85NoNo1599
84A:A:M68 A:A:N354 26.94962.8NoNo099
85A:A:F289 A:A:T347 13.389910.38YesNo1599
86A:A:F289 A:A:I287 13.83262.51YesYes1599
87A:A:K292 A:A:S250 58.85236.12NoYes1299
88A:A:L288 A:A:L290 17.29332.77YesNo099
89A:A:F346 A:A:L290 18.07887.31YesNo059
90A:A:F346 A:A:Q323 23.579516.4YesNo055
91A:A:L319 A:A:Q323 25.14996.65NoNo035
92A:A:L296 A:A:L319 27.50512.77YesNo083
93A:A:L296 A:A:S250 51.03261.5YesYes089
94A:A:F330 A:A:L288 11.00693.65YesYes689
95A:A:F252 A:A:L296 22.00892.44YesYes098
96A:A:F252 A:A:I305 16.51038.79YesYes096
97B:B:F199 B:B:W211 22.826212.03YesYes598
98B:B:F199 B:B:L190 24.2773.65YesYes595
99B:B:L190 B:B:R150 26.6972.43YesNo056
100B:B:H62 B:B:R150 28.74316.93NoNo066
101B:B:H62 B:B:Y105 28.92584.36NoYes066
102B:B:V71 B:B:Y105 14.72592.52YesYes086
103B:B:L79 B:B:V71 15.07122.98NoYes078
104B:B:V112 B:B:Y105 14.74942.52NoYes086
105B:B:V112 B:B:Y124 14.82973.79NoYes086
106B:B:I229 B:B:T243 17.47974.56NoYes278
107B:B:G202 B:B:I229 19.73263.53NoNo067
108B:B:G202 B:B:S201 19.91791.86NoNo069
109B:B:S201 B:B:W211 20.07454.94NoYes098
110B:B:M262 B:B:Y264 20.431410.78YesYes2545
111B:B:L30 B:B:M262 22.73577.07NoYes054
112B:B:L30 B:B:T34 23.06372.95NoNo055
113B:B:I37 B:B:T34 23.72343.04YesNo025
114B:B:I37 B:B:R283 25.346.26YesYes029
115B:B:R283 G:G:L51 27.32146.07YesYes096
116G:G:D48 G:G:L51 29.84568.14YesYes096
117G:G:D48 G:G:P49 31.20883.22YesNo097
118B:B:M325 G:G:P49 31.90026.71YesNo057
119B:B:D323 B:B:M325 16.08334.16NoYes075
120B:B:D323 B:B:T321 16.24257.23NoNo177
121B:B:T321 B:B:W63 16.780810.92NoYes177
122B:B:L70 B:B:W63 17.13684.56NoYes157
123B:B:M325 B:B:N340 16.12032.8YesYes059
124B:B:N340 G:G:F61 16.96923.62YesYes198
125R:R:N499 R:R:T442 15.59335.85NoYes496
126R:R:R502 R:R:Y441 85.4444.12YesYes485
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7SF8
Class B2
SubFamily Adhesion
Type Adhesion
SubType ADGRG1
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi2-G13)/Beta1/Gamma2
PDB Resolution 2.7
Date 2022-04-27
D.O.I. 10.1038/s41586-022-04575-7
Net Summary
Imin 2.44
Number of Linked Nodes 815
Number of Links 969
Number of Hubs 147
Number of Links mediated by Hubs 545
Number of Communities 31
Number of Nodes involved in Communities 214
Number of Links involved in Communities 286
Path Summary
Number Of Nodes in MetaPath 127
Number Of Links MetaPath 126
Number of Shortest Paths 5149771
Length Of Smallest Path 3
Average Path Length 37.6389
Length of Longest Path 61
Minimum Path Strength 1.235
Average Path Strength 5.52966
Maximum Path Strength 19.68
Minimum Path Correlation 0.7
Average Path Correlation 0.991343
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.7037
Average % Of Corr. Nodes 36.764
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.083
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ9Y653
Sequence
>7SF8_Chain_R
TYFAVLMVS SVEVDAVHK HYLSLLSYV GCVVSALAC LVTIAAYLC 
SRRKPRDYT IKVHMNLLL AVFLLDTSF LLSEPVALT GSEAGCRAS 
AIFLHFSLL TCLSWMGLE GYNLYRLVV EVFGTYVPG YLLKLSAMG 
WGFPIFLVT LVALVDVDN YGPIILASM CWIRDSLVS YITNLGLFS 
LVFLFNMAM LATMVVQIL RWSHVLTLL GLSLVLGLP WALIFFSFA 
SGTFQLVVL YLFSIITSF QGFLIFIWY WSMRL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtQ14344
Sequence
>7SF8_Chain_A
EDKAAAERS KEIDKCLSR EKTYVKRLV KILLLGADN SGKSTFLKQ 
MRIKGIHEY DFEIKNVPF KMVDVGGQR SERKRWFEC FDSVTSILF 
LVDSSDFNR LTESLNDFE TIVNNRVFS NVSIILFLN KTDLLEEKV 
QIVSIKDYF LEFEGDPHC LRDVQKFLV ECFRNKRRD QQQKPLYHH 
FTTAINTEN ARLIFRDVK DTILHDNLK QLMLQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7SF8_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7SF8_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7SF8B2AdhesionAdhesionADGRG1Homo sapiens--chim(NtGi2-G13)/&β;1/&γ;22.72022-04-2710.1038/s41586-022-04575-7




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7SF8.zip



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