psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T383	R:R:V387	4.76	No	No	0	9	9
2	R:R:E464	R:R:T383	4.23	No	No	0	5	9
3	R:R:L547	R:R:T383	4.42	No	No	0	6	9
4	R:R:V387	R:R:Y384	5.05	No	No	0	9	8
5	R:R:K400	R:R:Y384	3.58	No	No	0	5	8
6	R:R:L403	R:R:Y384	5.86	No	No	0	9	8
7	R:R:F385	R:R:S407	3.96	No	No	0	9	8
8	R:R:F385	R:R:F460	10.72	No	No	0	9	9
9	R:R:F385	R:R:T647	5.19	No	No	0	9	9
10	R:R:F460	R:R:L388	6.09	No	No	0	9	9
11	R:R:L388	R:R:W563	4.56	No	Yes	0	9	9
12	R:R:I626	R:R:M389	4.37	No	No	0	8	8
13	R:R:H399	R:R:V395	4.15	Yes	No	0	7	6
14	R:R:D396	R:R:H399	5.04	No	Yes	0	6	7
15	R:R:H399	R:R:L637	6.43	Yes	No	0	7	5
16	R:R:H399	R:R:Y641	5.44	Yes	Yes	0	7	8
17	R:R:K400	R:R:S404	3.06	No	No	0	5	8
18	R:R:H401	R:R:Y402	9.8	No	No	0	4	6
19	R:R:H401	R:R:L405	3.86	No	No	0	4	6
20	R:R:L403	R:R:Y641	9.38	No	Yes	0	9	8
21	R:R:L403	R:R:S644	3	No	No	0	9	8
22	R:R:L461	R:R:Y408	3.52	No	No	0	8	7
23	R:R:G410	R:R:S648	3.71	Yes	No	5	9	9
24	R:R:F649	R:R:G410	9.03	No	Yes	5	8	9
25	R:R:C411	R:R:D457	9.34	No	No	0	9	9
26	R:R:C411	R:R:L461	4.76	No	No	0	9	8
27	R:R:F652	R:R:V413	6.55	No	No	0	5	7
28	R:R:D457	R:R:S414	4.42	No	No	0	9	9
29	R:R:G651	R:R:S414	3.71	No	No	0	9	9
30	R:R:A417	R:R:F655	4.16	No	Yes	0	8	8
31	R:R:C418	R:R:L450	3.17	No	No	0	8	7
32	R:R:C418	R:R:V453	3.42	No	No	0	8	9
33	R:R:L450	R:R:T421	2.95	No	No	0	7	8
34	R:R:F655	R:R:T421	5.19	Yes	No	6	8	8
35	R:R:T421	R:R:W659	4.85	No	Yes	6	8	5
36	R:R:K437	R:R:Y425	11.94	No	Yes	0	5	6
37	R:R:I443	R:R:Y425	4.84	Yes	Yes	7	6	6
38	R:R:K444	R:R:Y425	3.58	No	Yes	0	5	6
39	R:R:M447	R:R:Y425	10.78	No	Yes	7	7	6
40	R:R:R436	R:R:S428	5.27	No	No	0	7	6
41	R:R:K437	R:R:S428	6.12	No	No	0	5	6
42	R:R:R436	R:R:R662	3.2	No	No	0	7	7
43	R:R:R439	R:R:Y441	10.29	No	Yes	0	6	5
44	R:R:R439	R:R:Y511	8.23	No	No	0	6	9
45	R:R:D440	R:R:T442	2.89	No	No	0	8	6
46	R:R:D440	R:R:I443	7	No	Yes	0	8	6
47	R:R:R502	R:R:Y441	4.12	Yes	Yes	3	8	5
48	R:R:Y441	R:R:Y515	14.89	Yes	Yes	3	5	8
49	R:R:L516	R:R:Y441	7.03	No	Yes	0	6	5
50	R:R:H446	R:R:T442	5.48	No	No	0	9	6
51	R:R:N499	R:R:T442	5.85	No	No	0	9	6
52	R:R:I443	R:R:M447	2.92	Yes	No	7	6	7
53	R:R:I443	R:R:Y658	3.63	Yes	No	0	6	7
54	R:R:K444	R:R:L516	9.87	No	No	0	5	6
55	R:R:V445	R:R:W492	3.68	No	Yes	0	9	9
56	R:R:E496	R:R:V445	5.7	No	No	0	9	9
57	R:R:E496	R:R:H446	11.08	No	No	0	9	9
58	R:R:N448	R:R:W492	16.95	No	Yes	2	8	9
59	R:R:N448	R:R:W524	6.78	No	Yes	2	8	9
60	R:R:L449	R:R:W492	3.42	No	Yes	0	9	9
61	R:R:L451	R:R:W524	5.69	No	Yes	0	4	9
62	R:R:A452	R:R:T488	3.36	No	Yes	0	9	7
63	R:R:D457	R:R:V453	2.92	No	No	0	9	9
64	R:R:F454	R:R:T458	7.78	Yes	No	0	7	4
65	R:R:L455	R:R:S485	3	No	Yes	0	7	7
66	R:R:L456	R:R:S485	3	No	Yes	0	9	7
67	R:R:C489	R:R:L456	3.17	No	No	0	8	9
68	R:R:F481	R:R:S459	5.28	No	No	8	3	6
69	R:R:L482	R:R:S459	7.51	No	No	0	9	6
70	R:R:S459	R:R:S485	4.89	No	Yes	8	6	7
71	R:R:F460	R:R:L482	3.65	No	No	0	9	9
72	R:R:M561	R:R:S463	3.07	Yes	No	0	7	8
73	R:R:E464	R:R:M561	5.41	No	Yes	0	5	7
74	R:R:S478	R:R:V466	4.85	No	No	0	7	5
75	R:R:G470	R:R:T469	3.64	No	No	0	3	4
76	R:R:G474	R:R:S471	3.71	No	No	0	4	4
77	R:R:E472	R:R:R476	11.63	No	No	0	3	4
78	R:R:C475	R:R:P544	5.65	No	No	0	9	3
79	R:R:C475	R:R:C562	7.28	No	No	0	9	9
80	R:R:A479	R:R:Y542	4	No	Yes	0	8	9
81	R:R:I480	R:R:Y542	9.67	No	Yes	0	6	9
82	R:R:F481	R:R:S485	3.96	No	Yes	8	3	7
83	R:R:L482	R:R:W563	9.11	No	Yes	0	9	9
84	R:R:H483	R:R:L487	10.29	Yes	No	1	9	9
85	R:R:H483	R:R:V531	4.15	Yes	No	1	9	9
86	R:R:H483	R:R:Y542	7.62	Yes	Yes	1	9	9
87	R:R:H483	R:R:W563	4.23	Yes	Yes	1	9	9
88	R:R:H483	R:R:I564	6.63	Yes	No	1	9	8
89	R:R:H483	R:R:T573	5.48	Yes	Yes	1	9	7
90	R:R:H483	R:R:N574	6.38	Yes	No	1	9	8
91	R:R:F484	R:R:T488	5.19	No	Yes	2	6	7
92	R:R:F484	R:R:P527	5.78	No	No	2	6	9
93	R:R:F484	R:R:I528	5.02	No	No	0	6	5
94	R:R:L487	R:R:L530	5.54	No	No	0	9	5
95	R:R:L487	R:R:T573	2.95	No	Yes	1	9	7
96	R:R:T488	R:R:W524	7.28	Yes	Yes	2	7	9
97	R:R:P527	R:R:T488	3.5	No	Yes	2	9	7
98	R:R:F578	R:R:L490	4.87	Yes	No	0	7	7
99	R:R:L495	R:R:W492	7.97	No	Yes	0	8	9
100	R:R:W492	R:R:W524	14.06	Yes	Yes	2	9	9
101	R:R:G620	R:R:M493	5.24	No	No	0	9	9
102	R:R:M493	R:R:W623	3.49	No	Yes	0	9	9
103	R:R:G494	R:R:V581	3.68	No	No	0	8	7
104	R:R:G494	R:R:N585	3.39	No	Yes	0	8	9
105	R:R:E496	R:R:V618	8.56	No	No	0	9	9
106	R:R:G497	R:R:N585	3.39	No	Yes	0	8	9
107	R:R:Y498	R:R:Y515	2.98	No	Yes	0	8	8
108	R:R:N499	R:R:R502	4.82	No	Yes	3	9	8
109	R:R:N499	R:R:Y515	5.81	No	Yes	3	9	8
110	R:R:L500	R:R:M592	8.48	No	Yes	0	9	9
111	R:R:V505	R:R:Y501	13.88	No	No	0	8	9
112	R:R:E506	R:R:Y501	12.35	No	No	0	8	9
113	R:R:M588	R:R:Y501	5.99	No	No	0	8	9
114	R:R:L503	R:R:R502	6.07	No	Yes	0	8	8
115	R:R:R502	R:R:Y515	16.46	Yes	Yes	3	8	8
116	R:R:M592	R:R:V504	3.04	Yes	No	0	9	8
117	R:R:F508	R:R:V507	3.93	No	No	0	9	9
118	R:R:P513	R:R:Y511	5.56	No	No	0	5	9
119	R:R:P513	R:R:V512	3.53	No	No	0	5	6
120	R:R:V512	R:R:Y515	11.36	No	Yes	0	6	8
121	R:R:G514	R:R:K518	3.49	No	No	0	6	9
122	R:R:L519	R:R:Y515	8.21	No	Yes	0	8	8
123	R:R:S520	R:R:W524	3.71	No	Yes	0	7	9
124	R:R:G525	R:R:I528	3.53	No	No	0	9	5
125	R:R:F526	R:R:P527	2.89	No	No	0	4	9
126	R:R:F526	R:R:L530	6.09	No	No	0	4	5
127	R:R:F529	R:R:L533	14.61	No	No	0	3	5
128	R:R:V531	R:R:Y542	5.05	No	Yes	1	9	9
129	R:R:V534	R:R:Y542	5.05	No	Yes	0	6	9
130	R:R:V534	R:R:V569	3.21	No	Yes	0	6	8
131	R:R:D538	R:R:N541	5.39	No	No	9	5	6
132	R:R:D538	R:R:R565	3.57	No	No	9	5	5
133	R:R:D540	R:R:V539	4.38	No	No	0	5	4
134	R:R:N541	R:R:R565	6.03	No	No	9	6	5
135	R:R:N541	R:R:V569	4.43	No	Yes	0	6	8
136	R:R:G543	R:R:P544	4.06	No	No	0	9	3
137	R:R:I545	R:R:M561	4.37	No	Yes	1	3	7
138	R:R:I545	R:R:W563	5.87	No	Yes	1	3	9
139	R:R:M561	R:R:W563	5.82	Yes	Yes	1	7	9
140	R:R:I564	R:R:W563	17.62	No	Yes	1	8	9
141	R:R:D566	R:R:V569	2.92	No	Yes	0	6	8
142	R:R:T573	R:R:V569	3.17	Yes	Yes	0	7	8
143	R:R:N574	R:R:S570	4.47	No	No	0	8	7
144	R:R:N574	R:R:T573	4.39	No	Yes	1	8	7
145	R:R:G576	R:R:S579	3.71	No	No	0	8	6
146	R:R:F578	R:R:F582	5.36	Yes	No	0	7	7
147	R:R:F578	R:R:W623	4.01	Yes	Yes	0	7	9
148	R:R:F578	R:R:F627	4.29	Yes	No	0	7	8
149	R:R:F582	R:R:M586	8.71	No	No	0	7	4
150	R:R:A624	R:R:F582	6.93	No	No	0	6	7
151	R:R:F584	R:R:N585	3.62	No	Yes	0	6	9
152	R:R:F584	R:R:M588	9.95	No	No	0	6	8
153	R:R:L619	R:R:N585	13.73	No	Yes	0	9	9
154	R:R:H608	R:R:S607	6.97	No	No	0	8	6
155	R:R:T611	R:R:W657	3.64	No	Yes	0	8	9
156	R:R:G614	R:R:W657	9.85	No	Yes	0	9	9
157	R:R:L617	R:R:L653	4.15	No	No	0	7	7
158	R:R:L619	R:R:L621	5.54	No	No	0	9	7
159	R:R:I646	R:R:P622	3.39	No	No	0	5	9
160	R:R:F643	R:R:W623	3.01	Yes	Yes	4	9	9
161	R:R:T647	R:R:W623	12.13	No	Yes	4	9	9
162	R:R:Q650	R:R:W623	12.05	No	Yes	0	9	9
163	R:R:I626	R:R:S629	4.64	No	No	0	8	8
164	R:R:F643	R:R:I626	12.56	Yes	No	0	9	8
165	R:R:G633	R:R:T634	3.64	No	No	0	8	6
166	R:R:F643	R:R:T647	10.38	Yes	No	4	9	9
167	R:R:F649	R:R:S648	5.28	No	No	5	8	9
168	R:R:F652	R:R:I656	5.02	No	No	0	5	7
169	R:R:F655	R:R:W659	7.02	Yes	Yes	6	8	5
170	R:R:M661	R:R:W657	3.49	No	Yes	0	7	9
171	R:R:W659	R:R:Y658	12.54	Yes	No	0	5	7
172	R:R:Q636	R:R:V393	2.87	No	No	0	5	4
173	R:R:Q595	R:R:V504	2.87	No	No	0	5	8
174	R:R:I645	R:R:L406	2.85	No	No	0	9	8
175	R:R:I422	R:R:L426	2.85	No	No	0	6	4
176	R:R:I422	R:R:L451	2.85	No	No	0	6	4
177	R:R:I654	R:R:L450	2.85	No	No	0	8	7
178	R:R:I654	R:R:L617	2.85	No	No	0	8	7
179	R:R:L621	R:R:M586	2.83	No	No	0	7	4
180	R:R:L615	R:R:M592	2.83	No	Yes	0	9	9
181	R:R:G523	R:R:W492	2.81	No	Yes	0	9	9
182	R:R:A386	R:R:F643	2.77	No	Yes	0	9	9
183	R:R:A415	R:R:F454	2.77	No	Yes	0	8	7
184	R:R:L456	R:R:L486	2.77	No	No	0	9	8
185	R:R:L490	R:R:L577	2.77	No	No	0	7	8
186	R:R:L589	R:R:L619	2.77	No	No	0	9	9
187	R:R:L640	R:R:Q636	2.66	No	No	0	5	5
188	R:R:F627	R:R:S579	2.64	No	No	0	8	6
189	R:R:F635	R:R:V639	2.62	No	No	0	6	7
190	R:R:R502	R:R:T510	2.59	Yes	No	0	8	6
191	R:R:V412	R:R:Y408	2.52	No	No	0	7	7
192	R:R:V609	R:R:W606	2.45	No	No	0	5	5
193	R:R:V618	R:R:W657	2.45	No	Yes	0	9	9
194	R:R:F454	R:R:L419	2.44	Yes	No	0	7	6
195	R:R:F454	R:R:L455	2.44	Yes	No	0	7	7
196	R:R:F627	R:R:L575	2.44	No	No	0	8	7
197	R:R:L406	R:R:Y641	2.34	No	Yes	0	8	8
198	R:R:F652	R:R:F655	2.14	No	Yes	0	5	8
199	R:R:G514	R:R:P513	2.03	No	No	0	6	5
200	R:R:G620	R:R:P622	2.03	No	No	0	9	9
201	R:R:A477	R:R:G474	1.95	No	No	0	5	4
202	R:R:G410	R:R:S414	1.86	Yes	No	0	9	9
203	R:R:G523	R:R:S491	1.86	No	No	0	9	8
204	R:R:G633	R:R:S632	1.86	No	No	0	8	9
205	R:R:G410	R:R:V409	1.84	Yes	No	0	9	7
206	R:R:A467	R:R:C562	1.81	No	No	0	8	9
207	R:R:G523	R:R:M522	1.75	No	No	0	9	5
208	R:R:C562	R:R:S478	1.72	No	No	0	9	7
209	R:R:A467	R:R:S560	1.71	No	No	0	8	6
210	R:R:A473	R:R:S471	1.71	No	No	0	4	4
211	R:R:G497	R:R:L500	1.71	No	No	0	8	9
212	R:R:G614	R:R:L613	1.71	No	No	0	9	7
213	R:R:S463	R:R:S478	1.63	No	No	0	8	7
214	R:R:S629	R:R:V390	1.62	No	Yes	0	8	6
215	R:R:S629	R:R:V639	1.62	No	No	0	8	7
216	R:R:A587	R:R:M588	1.61	No	No	0	6	8
217	R:R:V390	R:R:V393	1.6	Yes	No	0	6	4
218	R:R:S471	R:R:T469	1.6	No	No	0	4	4
219	R:R:T591	R:R:V504	1.59	No	No	0	6	8
220	R:R:T591	R:R:V505	1.59	No	No	0	6	8
221	R:R:A535	R:R:L536	1.58	No	No	0	5	5
222	R:R:E464	R:R:P465	1.57	No	No	0	5	4
223	R:R:I528	R:R:T532	1.52	No	No	0	5	4
224	R:R:F508	R:R:G509	1.51	No	No	0	9	9
225	R:R:L613	R:R:S616	1.5	No	No	0	7	9
226	R:R:L621	R:R:S616	1.5	No	No	0	7	9
227	R:R:L416	R:R:V412	1.49	No	No	0	7	7
228	R:R:L589	R:R:V593	1.49	No	No	0	9	6
229	R:R:L612	R:R:V593	1.49	No	No	0	8	6
230	R:R:L613	R:R:V609	1.49	No	No	0	7	5
231	R:R:L642	R:R:V638	1.49	No	No	0	7	6
232	R:R:L462	R:R:T458	1.47	No	No	0	6	4
233	R:R:D566	R:R:S567	1.47	No	No	0	6	4
234	R:R:D396	R:R:V398	1.46	No	No	0	6	2
235	R:R:I596	R:R:M592	1.46	No	Yes	0	8	9
236	R:R:A631	R:R:F635	1.39	No	No	0	8	6
237	R:R:L625	R:R:L642	1.38	No	No	0	8	7
238	R:R:H608	R:R:T611	1.37	No	No	0	8	8
239	R:R:D566	R:R:L568	1.36	No	No	0	6	3
240	R:R:D538	R:R:D540	1.33	No	No	0	5	5
241	R:R:F630	R:R:V390	1.31	No	Yes	0	8	6
242	R:R:F628	R:R:V639	1.31	No	No	0	7	7
243	R:R:A424	R:R:W659	1.3	No	Yes	0	5	5
244	R:R:S392	R:R:Y571	1.27	No	No	0	6	6
245	R:R:V390	R:R:Y571	1.26	Yes	No	0	6	6
246	R:R:F643	R:R:L625	1.22	Yes	No	0	9	8
247	R:R:L663	R:R:R662	1.21	No	No	0	4	7
248	R:R:D540	R:R:R476	1.19	No	No	0	5	4
249	R:R:Y402	R:R:Y641	0.99	No	Yes	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V390	1.4475	4	0	6
2	R:R:H399	5.265	4	0	7
3	R:R:G410	4.11	4	5	9
4	R:R:Y425	7.785	4	7	6
5	R:R:Y441	9.0825	4	3	5
6	R:R:I443	4.5975	4	7	6
7	R:R:F454	3.8575	4	0	7
8	R:R:H483	6.39714	7	1	9
9	R:R:S485	3.7125	4	8	7
10	R:R:T488	4.8325	4	2	7
11	R:R:W492	8.14833	6	2	9
12	R:R:R502	6.812	5	3	8
13	R:R:Y515	9.95167	6	3	8
14	R:R:W524	7.504	5	2	9
15	R:R:Y542	6.278	5	1	9
16	R:R:M561	4.6675	4	1	7
17	R:R:W563	7.86833	6	1	9
18	R:R:V569	3.4325	4	0	8
19	R:R:T573	3.9975	4	1	7
20	R:R:F578	4.6325	4	0	7
21	R:R:N585	6.0325	4	0	9
22	R:R:M592	3.9525	4	0	9
23	R:R:W623	6.938	5	4	9
24	R:R:Y641	4.5375	4	0	8
25	R:R:F643	5.988	5	4	9
26	R:R:F655	4.6275	4	6	8
27	R:R:W657	4.8575	4	0	9
28	R:R:W659	6.4275	4	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:V387	R:R:Y384	44.812	5.05	No	No	0	9	8
2	R:R:T383	R:R:V387	47.2468	4.76	No	No	0	9	9
3	R:R:L403	R:R:Y384	36.7475	5.86	No	No	0	9	8
4	R:R:F385	R:R:F460	97.1543	10.72	No	No	0	9	9
5	R:R:F460	R:R:L388	45.3359	6.09	No	No	0	9	9
6	R:R:L388	R:R:W563	45.8496	4.56	No	Yes	0	9	9
7	R:R:M561	R:R:W563	81.4978	5.82	Yes	Yes	1	7	9
8	R:R:E464	R:R:M561	57.2632	5.41	No	Yes	0	5	7
9	R:R:E464	R:R:T383	52.0855	4.23	No	No	0	5	9
10	R:R:F460	R:R:L482	53.986	3.65	No	No	0	9	9
11	R:R:L482	R:R:W563	62.8827	9.11	No	Yes	0	9	9
12	R:R:F643	R:R:I626	41.0931	12.56	Yes	No	0	9	8
13	R:R:F643	R:R:T647	32.8128	10.38	Yes	No	4	9	9
14	R:R:F385	R:R:T647	96.24	5.19	No	No	0	9	9
15	R:R:H399	R:R:Y641	14.6394	5.44	Yes	Yes	0	7	8
16	R:R:L403	R:R:Y641	31.2307	9.38	No	Yes	0	9	8
17	R:R:C411	R:R:D457	11.1876	9.34	No	No	0	9	9
18	R:R:D457	R:R:V453	26.0016	2.92	No	No	0	9	9
19	R:R:C418	R:R:V453	28.0358	3.42	No	No	0	8	9
20	R:R:C418	R:R:L450	30.0493	3.17	No	No	0	8	7
21	R:R:L450	R:R:T421	37.8159	2.95	No	No	0	7	8
22	R:R:T421	R:R:W659	38.4323	4.85	No	Yes	6	8	5
23	R:R:W659	R:R:Y658	51.9211	12.54	Yes	No	0	5	7
24	R:R:I443	R:R:Y658	53.4621	3.63	Yes	No	0	6	7
25	R:R:D440	R:R:I443	65.8106	7	No	Yes	0	8	6
26	R:R:D440	R:R:T442	67.3721	2.89	No	No	0	8	6
27	R:R:H446	R:R:T442	99.024	5.48	No	No	0	9	6
28	R:R:E496	R:R:H446	100	11.08	No	No	0	9	9
29	R:R:E496	R:R:V445	72.9813	5.7	No	No	0	9	9
30	R:R:V445	R:R:W492	72.8169	3.68	No	Yes	0	9	9
31	R:R:W492	R:R:W524	71.7999	14.06	Yes	Yes	2	9	9
32	R:R:T488	R:R:W524	74.7072	7.28	Yes	Yes	2	7	9
33	R:R:P527	R:R:T488	70.9472	3.5	No	Yes	2	9	7
34	R:R:F526	R:R:P527	77.5221	2.89	No	No	0	4	9
35	R:R:F526	R:R:L530	77.9022	6.09	No	No	0	4	5
36	R:R:L487	R:R:L530	78.9706	5.54	No	No	0	9	5
37	R:R:H483	R:R:L487	65.8106	10.29	Yes	No	1	9	9
38	R:R:H483	R:R:W563	93.7333	4.23	Yes	Yes	1	9	9
39	R:R:D457	R:R:S414	13.3655	4.42	No	No	0	9	9
40	R:R:F655	R:R:W659	10.2116	7.02	Yes	Yes	6	8	5
41	R:R:K437	R:R:Y425	11.0335	11.94	No	Yes	0	5	6
42	R:R:I443	R:R:Y425	15.0606	4.84	Yes	Yes	7	6	6
43	R:R:N499	R:R:R502	12.821	4.82	No	Yes	3	9	8
44	R:R:N499	R:R:T442	37.2509	5.85	No	No	0	9	6
45	R:R:N499	R:R:Y515	22.8067	5.81	No	Yes	3	9	8
46	R:R:V512	R:R:Y515	10.7664	11.36	No	Yes	0	6	8
47	R:R:F454	R:R:L455	11.28	2.44	Yes	No	0	7	7
48	R:R:L455	R:R:S485	13.4785	3	No	Yes	0	7	7
49	R:R:S459	R:R:S485	21.9745	4.89	No	Yes	8	6	7
50	R:R:L482	R:R:S459	26.2482	7.51	No	No	0	9	6
51	R:R:M561	R:R:S463	26.0633	3.07	Yes	No	0	7	8
52	R:R:S463	R:R:S478	23.2484	1.63	No	No	0	8	7
53	R:R:D538	R:R:D540	11.9067	1.33	No	No	0	5	5
54	R:R:D538	R:R:N541	14.7832	5.39	No	No	9	5	6
55	R:R:N541	R:R:V569	20.6287	4.43	No	Yes	0	6	8
56	R:R:T573	R:R:V569	32.3608	3.17	Yes	Yes	0	7	8
57	R:R:H483	R:R:T573	22.1697	5.48	Yes	Yes	1	9	7
58	R:R:C562	R:R:S478	17.557	1.72	No	No	0	9	7
59	R:R:H483	R:R:Y542	10.7767	7.62	Yes	Yes	1	9	9
60	R:R:F578	R:R:W623	81.1588	4.01	Yes	Yes	0	7	9
61	R:R:T647	R:R:W623	63.1703	12.13	No	Yes	4	9	9
62	R:R:M493	R:R:W623	11.9478	3.49	No	Yes	0	9	9
63	R:R:L619	R:R:N585	47.3187	13.73	No	Yes	0	9	9
64	R:R:L619	R:R:L621	56.8934	5.54	No	No	0	9	7
65	R:R:L621	R:R:M586	74.8613	2.83	No	No	0	7	4
66	R:R:F582	R:R:M586	75.5291	8.71	No	No	0	7	4
67	R:R:F578	R:R:F582	76.7619	5.36	Yes	No	0	7	7
68	R:R:E496	R:R:V618	57.9207	8.56	No	No	0	9	9
69	R:R:G497	R:R:N585	21.1629	3.39	No	Yes	0	8	9
70	R:R:F584	R:R:N585	18.9645	3.62	No	Yes	0	6	9
71	R:R:F584	R:R:M588	16.242	9.95	No	No	0	6	8
72	R:R:M588	R:R:Y501	10.8486	5.99	No	No	0	8	9
73	R:R:G497	R:R:L500	18.4405	1.71	No	No	0	8	9
74	R:R:L500	R:R:M592	16.0366	8.48	No	Yes	0	9	9
75	R:R:F578	R:R:F627	11.3006	4.29	Yes	No	0	7	8
76	R:R:V618	R:R:W657	57.0577	2.45	No	Yes	0	9	9
77	R:R:G614	R:R:L613	54.6949	1.71	No	No	0	9	7
78	R:R:L613	R:R:S616	57.2529	1.5	No	No	0	7	9
79	R:R:L621	R:R:S616	58.2186	1.5	No	No	0	7	9
80	R:R:I626	R:R:S629	35.6072	4.64	No	No	0	8	8
81	R:R:S629	R:R:V390	20.8342	1.62	No	Yes	0	8	6
82	R:R:S629	R:R:V639	12.3998	1.62	No	No	0	8	7
83	R:R:G614	R:R:W657	54.1812	9.85	No	Yes	0	9	9
84	R:R:F643	R:R:W623	21.9437	3.01	Yes	Yes	4	9	9
85	R:R:L487	R:R:T573	14.2285	2.95	No	Yes	1	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7SF8_nogp

PDB Summary
PDB	7SF8_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.89
Number of Linked Nodes	234
Number of Links	249
Number of Hubs	28
Number of Links mediated by Hubs	111
Number of Communities	9
Number of Nodes involved in Communities	38
Number of Links involved in Communities	44

Path Summary
Number Of Nodes in MetaPath	86
Number Of Links MetaPath	85
Number of Shortest Paths	28752
Length Of Smallest Path	3
Average Path Length	15.3504
Length of Longest Path	37
Minimum Path Strength	1.26
Average Path Strength	5.7036
Maximum Path Strength	13.91
Minimum Path Correlation	0.7
Average Path Correlation	0.91447
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	40.1527
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	29.5543
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • reproductive system development • gonad development • tube development • reproductive process • sex differentiation • animal organ development • developmental process involved in reproduction • male gonad development • male sex differentiation • multicellular organism development • development of primary male sexual characteristics • development of primary sexual characteristics • seminiferous tubule development • anatomical structure development • reproductive structure development • system development • regulation of biological process • cell population proliferation • regulation of cellular process • positive regulation of cell population proliferation • biological regulation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • cellular process • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • head development • central nervous system development • brain development • nervous system development • cellular developmental process • forebrain development • glial cell migration • telencephalon glial cell migration • cerebral cortex development • neurogenesis • telencephalon cell migration • forebrain cell migration • gliogenesis • cell differentiation • cell migration • cell motility • layer formation in cerebral cortex • cerebral cortex cell migration • cerebral cortex radially oriented cell migration • pallium development • anatomical structure morphogenesis • anatomical structure formation involved in morphogenesis • cerebral cortex radial glia-guided migration • telencephalon development • blood vessel morphogenesis • angiogenesis • vasculature development • circulatory system development • tube morphogenesis • blood vessel development • cellular response to stimulus • positive regulation of cell communication • small GTPase-mediated signal transduction • positive regulation of signal transduction • response to stimulus • signaling • regulation of small GTPase mediated signal transduction • regulation of signal transduction • intracellular signal transduction • Rho protein signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • regulation of signaling • positive regulation of intracellular signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • regulation of response to stimulus • regulation of cell communication • positive regulation of small GTPase mediated signal transduction • positive regulation of signaling • cell-cell signaling • cellular response to growth factor stimulus • cell surface receptor protein tyrosine kinase signaling pathway • cellular response to endogenous stimulus • regulation of vascular endothelial growth factor signaling pathway • enzyme-linked receptor protein signaling pathway • regulation of cellular response to vascular endothelial growth factor stimulus • cell surface receptor signaling pathway • response to endogenous stimulus • regulation of cellular response to growth factor stimulus • positive regulation of vascular endothelial growth factor signaling pathway • vascular endothelial growth factor signaling pathway • cellular response to vascular endothelial growth factor stimulus • response to growth factor • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cell adhesion • positive regulation of cell adhesion • regulation of cell adhesion • negative regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • phospholipase C-activating G protein-coupled receptor signaling pathway • multicellular organismal-level homeostasis • homeostatic process • hematopoietic stem cell homeostasis • homeostasis of number of cells • telencephalon regionalization • pattern specification process • cerebral cortex regionalization • regionalization • forebrain regionalization • negative regulation of locomotion • regulation of cell motility • negative regulation of neuron migration • regulation of neuron migration • regulation of cell migration • locomotion • negative regulation of cell migration • neuron migration • generation of neurons • regulation of locomotion • negative regulation of cell motility • cellular anatomical structure • membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • cell periphery • plasma membrane • membrane microdomain
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • cell periphery • plasma membrane • membrane microdomain • membrane raft • glial cell projection • cell projection • glial limiting end-foot • plasma membrane bounded cell projection • astrocyte end-foot • astrocyte projection • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • D5 dopamine receptor binding • dopamine receptor binding • enzyme regulator activity • hydrolase activity • GDP binding • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides • catalytic activity • pyrophosphatase activity • GTPase activity • nucleoside-triphosphatase regulator activity • GTPase regulator activity • guanyl-nucleotide exchange factor activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • G protein activity • cation binding • metal ion binding • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • circulatory system process • regulation of blood pressure • blood circulation • developmental process • cellular developmental process • cell differentiation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of vascular associated smooth muscle cell migration • negative regulation of locomotion • vascular associated smooth muscle cell migration • regulation of cell motility • negative regulation of vascular associated smooth muscle cell migration • regulation of smooth muscle cell migration • negative regulation of biological process • smooth muscle cell migration • muscle cell migration • negative regulation of smooth muscle cell migration • regulation of locomotion • regulation of cell migration • negative regulation of cellular process • negative regulation of cell motility • cell migration • cell motility • locomotion • negative regulation of cell migration • regulation of fibroblast migration • fibroblast migration • ameboidal-type cell migration • multicellular organism development • embryo development ending in birth or egg hatching • chordate embryonic development • anatomical structure development • embryo development • in utero embryonic development • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of developmental process • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • regulation of anatomical structure morphogenesis • regulation of body fluid levels • wound healing • cell activation • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • platelet activation • branching morphogenesis of an epithelial tube • angiogenesis • tube morphogenesis • epithelial tube morphogenesis • blood vessel development • system development • epithelium development • blood vessel morphogenesis • tube development • morphogenesis of an epithelium • tissue development • vasculature development • circulatory system development • branching involved in blood vessel morphogenesis • tissue morphogenesis • morphogenesis of a branching structure • anatomical structure formation involved in morphogenesis • morphogenesis of a branching epithelium • regulation of cellular component organization • cellular component organization • cellular component biogenesis • cellular component assembly • regulation of postsynapse assembly • cell junction assembly • regulation of synapse structure or activity • synapse organization • cellular component organization or biogenesis • regulation of synapse assembly • postsynapse organization • postsynapse assembly • regulation of postsynapse organization • nervous system development • regulation of cellular component biogenesis • regulation of cell junction assembly • regulation of synapse organization • cell junction organization • synapse assembly • Rho-activating G protein-coupled receptor signaling pathway • regulation of signaling • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • regulation of signal transduction • intracellular signal transduction • regulation of intracellular signal transduction • regulation of response to stimulus • intracellular signaling cassette • regulation of cell communication • Rho protein signal transduction • regulation of vascular associated smooth muscle cell proliferation • negative regulation of cell population proliferation • cell population proliferation • regulation of smooth muscle cell proliferation • negative regulation of vascular associated smooth muscle cell proliferation • smooth muscle cell proliferation • negative regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • anchoring junction • cell junction • focal adhesion • cell-substrate junction • intracellular anatomical structure • pigment granule • intracellular vesicle • intracellular membrane-bounded organelle • intracellular organelle • melanosome • cytoplasmic vesicle • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • cytosol • brush border membrane • cluster of actin-based cell projections • brush border • plasma membrane region • cell projection membrane • postsynapse • synapse • nucleus • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9Y653
Sequence	>7SF8_nogp_Chain_R T Y F A V L M V S S V E V D A V H K H Y L S L L S Y V G C V V S A L A C L V T I A A Y L C S R R K P R D Y T I K V H M N L L L A V F L L D T S F L L S E P V A L T G S E A G C R A S A I F L H F S L L T C L S W M G L E G Y N L Y R L V V E V F G T Y V P G Y L L K L S A M G W G F P I F L V T L V A L V D V D N Y G P I I L A S M C W I R D S L V S Y I T N L G L F S L V F L F N M A M L A T M V V Q I L R W S H V L T L L G L S L V L G L P W A L I F F S F A S G T F Q L V V L Y L F S I I T S F Q G F L I F I W Y W S M R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7SF8	B2	Adhesion	Adhesion	ADGRG1	Homo sapiens	-	-	chim(NtGi2-G13)/β1/γ2	2.7	2022-04-27	10.1038/s41586-022-04575-7
	7SF8 (No Gprot)	B2	Adhesion	Adhesion	ADGRG1	Homo sapiens	-	-		2.7	2022-04-27	10.1038/s41586-022-04575-7

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7SF8_nogp.zip

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