psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:K13	R:R:N12	6.99	No	No	0	3	2
2	R:R:V14	R:R:Y18	11.36	No	Yes	0	8	7
3	R:R:L185	R:R:V14	4.47	Yes	No	0	3	8
4	R:R:H17	R:R:L176	6.43	No	No	0	7	3
5	R:R:C179	R:R:H17	5.9	No	No	0	9	7
6	R:R:H17	R:R:L185	6.43	No	Yes	0	7	3
7	R:R:L98	R:R:Y18	4.69	Yes	Yes	0	4	7
8	R:R:W105	R:R:Y18	8.68	Yes	Yes	0	8	7
9	R:R:P184	R:R:Y18	6.95	No	Yes	0	7	7
10	R:R:T21	R:R:Y20	4.99	No	No	0	7	5
11	R:R:L176	R:R:Y20	10.55	No	No	0	3	5
12	R:R:K269	R:R:R33	3.71	No	Yes	0	4	5
13	R:R:H271	R:R:R33	18.05	No	Yes	1	4	5
14	L:L:?1	R:R:R33	5.52	Yes	Yes	1	0	5
15	R:R:S37	R:R:T90	3.2	No	Yes	0	5	6
16	R:R:I40	R:R:T90	6.08	No	Yes	0	6	6
17	R:R:T90	R:R:V41	4.76	Yes	No	0	6	5
18	R:R:L282	R:R:L43	4.15	No	No	0	6	6
19	R:R:I47	R:R:T278	4.56	No	No	4	8	7
20	R:R:I47	R:R:S281	7.74	No	No	4	8	9
21	R:R:I47	R:R:L282	5.71	No	No	0	8	6
22	R:R:V48	R:R:V84	3.21	No	No	0	6	5
23	R:R:D79	R:R:N51	14.81	Yes	No	0	9	9
24	R:R:N51	R:R:P285	9.77	No	No	0	9	9
25	R:R:A76	R:R:V54	3.39	No	No	0	9	9
26	R:R:V58	R:R:Y69	5.05	No	No	0	7	9
27	R:R:G73	R:R:V58	5.52	No	No	0	6	7
28	R:R:N61	R:R:R60	13.26	No	No	0	7	4
29	R:R:F64	R:R:K63	6.2	No	No	0	9	6
30	R:R:H65	R:R:Y69	19.6	No	No	0	7	9
31	R:R:A67	R:R:M148	3.22	No	Yes	0	5	7
32	R:R:F71	R:R:M68	4.98	Yes	No	0	8	8
33	R:R:M68	R:R:Y140	4.79	No	Yes	0	8	8
34	R:R:L70	R:R:M148	9.9	No	Yes	0	4	7
35	R:R:F71	R:R:I126	5.02	Yes	No	0	8	9
36	R:R:E129	R:R:F71	12.83	No	Yes	0	9	8
37	R:R:F71	R:R:M148	6.22	Yes	Yes	0	8	7
38	R:R:F71	R:R:L151	4.87	Yes	No	0	8	5
39	R:R:I152	R:R:N74	14.16	No	No	0	7	9
40	R:R:N74	R:R:W156	5.65	No	Yes	0	9	9
41	R:R:L75	R:R:S122	7.51	Yes	No	0	9	8
42	R:R:L123	R:R:L75	5.54	No	Yes	2	9	9
43	R:R:L75	R:R:N284	4.12	Yes	Yes	2	9	9
44	R:R:A118	R:R:S78	3.42	No	No	5	8	8
45	R:R:S78	R:R:W156	3.71	No	Yes	5	8	9
46	R:R:D79	R:R:S281	5.89	Yes	No	0	9	9
47	R:R:L81	R:R:T115	4.42	No	No	0	7	7
48	R:R:N89	R:R:R108	4.82	No	Yes	0	5	6
49	R:R:A112	R:R:N89	4.69	No	No	0	6	5
50	L:L:?1	R:R:N89	8.32	Yes	No	0	0	5
51	R:R:L92	R:R:T97	5.9	No	No	0	4	5
52	R:R:L92	R:R:R108	4.86	No	Yes	0	4	6
53	R:R:L98	R:R:R108	3.64	Yes	Yes	0	4	6
54	L:L:?1	R:R:L98	6.29	Yes	Yes	0	0	4
55	R:R:L100	R:R:Q104	14.64	No	No	0	6	4
56	R:R:P102	R:R:T101	3.5	No	No	0	2	6
57	R:R:F106	R:R:W105	8.02	Yes	Yes	1	5	8
58	R:R:R108	R:R:W105	8	Yes	Yes	1	6	8
59	R:R:E109	R:R:W105	25.08	Yes	Yes	1	5	8
60	R:R:L185	R:R:W105	10.25	Yes	Yes	1	3	8
61	R:R:W105	R:R:Y186	3.86	Yes	Yes	1	8	5
62	R:R:F106	R:R:I167	5.02	Yes	No	0	5	4
63	R:R:F106	R:R:N171	3.62	Yes	No	0	5	6
64	R:R:F106	R:R:L185	7.31	Yes	Yes	1	5	3
65	R:R:E109	R:R:R108	13.96	Yes	Yes	1	5	6
66	R:R:E109	R:R:Y186	5.61	Yes	Yes	1	5	5
67	L:L:?1	R:R:E109	7.03	Yes	Yes	1	0	5
68	R:R:F113	R:R:L162	3.65	Yes	No	0	5	5
69	R:R:F113	R:R:Y190	10.32	Yes	Yes	0	5	6
70	R:R:F113	R:R:V194	5.24	Yes	No	0	5	6
71	L:L:?1	R:R:F113	6.46	Yes	Yes	0	0	5
72	R:R:I114	R:R:S159	4.64	No	No	0	6	8
73	R:R:L116	R:R:W246	6.83	No	Yes	0	7	8
74	R:R:S117	R:R:S159	3.26	No	No	0	5	8
75	L:L:?1	R:R:S117	5.69	Yes	No	0	0	5
76	R:R:A118	R:R:W156	6.48	No	Yes	5	8	9
77	R:R:A118	R:R:S159	3.42	No	No	0	8	8
78	R:R:F198	R:R:V120	3.93	Yes	No	1	7	7
79	R:R:V120	R:R:W246	4.9	No	Yes	1	7	8
80	R:R:F121	R:R:S155	3.96	Yes	No	0	5	7
81	R:R:F121	R:R:I158	10.05	Yes	No	0	5	4
82	R:R:F121	R:R:I201	5.02	Yes	No	0	5	7
83	L:L:?1	R:R:F121	3.69	Yes	Yes	0	0	5
84	R:R:L123	R:R:N284	5.49	No	Yes	2	9	9
85	R:R:L123	R:R:Y288	3.52	No	Yes	2	9	9
86	R:R:I201	R:R:L124	7.14	No	No	0	7	7
87	R:R:I205	R:R:L124	4.28	No	No	0	8	7
88	R:R:I126	R:R:R130	5.01	No	No	2	9	9
89	R:R:I126	R:R:Y288	3.63	No	Yes	2	9	9
90	R:R:A127	R:R:L208	3.15	No	No	0	8	7
91	R:R:A127	R:R:Y209	4	No	Yes	0	8	9
92	R:R:I128	R:R:L151	4.28	No	No	0	6	5
93	R:R:I128	R:R:L208	4.28	No	No	0	6	7
94	R:R:E129	R:R:Y140	7.86	No	Yes	0	9	8
95	R:R:E129	R:R:R147	13.96	No	No	0	9	6
96	R:R:R130	R:R:Y209	8.23	No	Yes	2	9	9
97	R:R:R130	R:R:Y288	9.26	No	Yes	2	9	9
98	R:R:H131	R:R:L208	6.43	No	No	0	7	7
99	R:R:H131	R:R:R211	9.03	No	No	0	7	5
100	R:R:H131	R:R:I212	3.98	No	No	0	7	9
101	R:R:R147	R:R:V132	9.15	No	No	0	6	5
102	R:R:A133	R:R:Y140	8.01	No	Yes	0	8	8
103	R:R:I134	R:R:I212	4.42	No	No	0	9	9
104	R:R:K136	R:R:K138	11.49	No	No	0	5	6
105	R:R:D143	R:R:K144	8.3	No	No	0	4	6
106	R:R:L165	R:R:W170	4.56	No	No	0	6	5
107	R:R:L165	R:R:Y190	5.86	No	Yes	0	6	6
108	R:R:P166	R:R:Y186	8.34	Yes	Yes	1	5	5
109	R:R:P166	R:R:Y190	9.74	Yes	Yes	1	5	6
110	R:R:L173	R:R:N171	9.61	No	No	0	4	6
111	R:R:C172	R:R:C179	7.28	No	No	0	5	9
112	R:R:A187	R:R:C172	3.61	No	No	0	4	5
113	R:R:L173	R:R:L185	5.54	No	Yes	0	4	3
114	R:R:E177	R:R:H175	4.92	No	No	0	3	3
115	R:R:T181	R:R:V182	3.17	No	Yes	3	5	4
116	R:R:D256	R:R:T181	7.23	Yes	No	3	5	5
117	R:R:L267	R:R:T181	5.9	Yes	No	3	3	5
118	R:R:L183	R:R:V182	4.47	No	Yes	0	5	4
119	R:R:D256	R:R:V182	4.38	Yes	Yes	3	5	4
120	R:R:A270	R:R:V182	3.39	No	Yes	0	5	4
121	R:R:L183	R:R:Y186	11.72	No	Yes	0	5	5
122	L:L:?1	R:R:L183	4.19	Yes	No	0	0	5
123	R:R:Y186	R:R:Y190	4.96	Yes	Yes	1	5	6
124	R:R:L192	R:R:Y257	5.86	No	No	0	4	4
125	R:R:F250	R:R:V195	3.93	No	No	0	6	5
126	R:R:F198	R:R:W246	10.02	Yes	Yes	1	7	8
127	R:R:F198	R:R:F250	7.5	Yes	No	0	7	6
128	L:L:?1	R:R:F198	3.69	Yes	Yes	1	0	7
129	R:R:T236	R:R:Y209	3.75	No	Yes	0	6	9
130	R:R:L239	R:R:Y209	9.38	No	Yes	0	7	9
131	R:R:Y209	R:R:Y288	4.96	Yes	Yes	2	9	9
132	R:R:L229	R:R:Y213	3.52	No	No	0	4	6
133	R:R:L232	R:R:Y213	4.69	No	No	0	7	6
134	R:R:K233	R:R:Y213	16.72	No	No	0	7	6
135	R:R:L232	R:R:V216	4.47	No	No	0	7	8
136	R:R:L229	R:R:R217	3.64	No	No	0	4	5
137	R:R:L231	R:R:T234	4.42	No	No	0	8	9
138	R:R:L232	R:R:T236	4.42	No	No	0	7	6
139	R:R:V238	R:R:V241	3.21	No	No	2	8	7
140	R:R:I287	R:R:V238	4.61	No	No	2	8	8
141	R:R:L283	R:R:V241	4.47	No	No	0	6	7
142	R:R:I287	R:R:V241	4.61	No	No	2	8	7
143	R:R:F242	R:R:W246	6.01	No	Yes	0	9	8
144	R:R:C245	R:R:L279	4.76	No	No	0	8	5
145	R:R:C245	R:R:N280	3.15	No	No	0	8	9
146	R:R:S277	R:R:W246	7.41	No	Yes	0	7	8
147	R:R:N280	R:R:W246	7.91	No	Yes	0	9	8
148	L:L:?1	R:R:W246	6.04	Yes	Yes	1	0	8
149	R:R:L247	R:R:P248	3.28	No	No	0	5	9
150	R:R:P248	R:R:V276	10.6	No	No	0	9	7
151	R:R:F250	R:R:L254	3.65	No	No	0	6	5
152	R:R:F273	R:R:I252	15.07	No	No	0	5	5
153	R:R:F274	R:R:L253	3.65	No	No	0	6	6
154	R:R:C259	R:R:L255	3.17	No	No	0	4	5
155	R:R:L255	R:R:L267	4.15	No	Yes	0	5	3
156	R:R:D256	R:R:L267	5.43	Yes	Yes	3	5	3
157	R:R:C259	R:R:S263	3.44	No	No	6	4	1
158	R:R:C259	R:R:C264	7.28	No	No	6	4	2
159	R:R:P260	R:R:S263	8.91	No	No	0	2	1
160	R:R:H262	R:R:V261	6.92	No	No	0	4	1
161	R:R:C264	R:R:S263	3.44	No	No	6	2	1
162	R:R:K269	R:R:Y272	5.97	No	No	0	4	4
163	R:R:H271	R:R:Y272	8.71	No	No	0	4	4
164	L:L:?1	R:R:H271	3.9	Yes	No	1	0	4
165	R:R:F274	R:R:S277	3.96	No	No	0	6	7
166	L:L:?1	R:R:F274	7.38	Yes	No	0	0	6
167	R:R:S281	R:R:T278	4.8	No	No	4	9	7
168	R:R:N280	R:R:N284	6.81	No	Yes	0	9	9
169	R:R:N284	R:R:Y288	3.49	Yes	Yes	2	9	9
170	R:R:E50	R:R:P285	3.14	No	No	0	7	9
171	R:R:I200	R:R:S199	3.1	No	No	0	4	4
172	R:R:A82	R:R:D79	3.09	No	Yes	0	8	9
173	R:R:M148	R:R:S145	3.07	Yes	No	0	7	3
174	R:R:L80	R:R:V48	2.98	No	No	0	6	6
175	R:R:L72	R:R:V58	2.98	No	No	0	8	7
176	R:R:L253	R:R:V191	2.98	No	No	0	6	5
177	R:R:L239	R:R:V206	2.98	No	No	0	7	5
178	R:R:L283	R:R:V286	2.98	No	No	0	6	5
179	R:R:L192	R:R:T196	2.95	No	No	0	4	4
180	R:R:D256	R:R:S180	2.94	Yes	No	0	5	5
181	R:R:F273	R:R:P248	2.89	No	No	0	5	9
182	R:R:I114	R:R:L160	2.85	No	No	0	6	4
183	R:R:I266	R:R:L267	2.85	No	Yes	0	3	3
184	R:R:K22	R:R:N19	2.8	No	No	0	6	9
185	R:R:C44	R:R:F86	2.79	No	No	0	6	7
186	R:R:L52	R:R:L80	2.77	No	No	0	4	6
187	R:R:A57	R:R:R60	2.77	No	No	0	8	4
188	R:R:A125	R:R:F71	2.77	No	Yes	0	7	8
189	R:R:D79	R:R:L75	2.71	Yes	Yes	0	9	9
190	R:R:R33	R:R:S93	2.64	Yes	No	0	5	5
191	R:R:F86	R:R:T90	2.59	No	Yes	0	7	6
192	R:R:F86	R:R:T278	2.59	No	No	0	7	7
193	R:R:A249	R:R:W246	2.59	No	Yes	0	6	8
194	R:R:S66	R:R:Y140	2.54	No	Yes	0	7	8
195	R:R:V261	R:R:Y20	2.52	No	No	0	1	5
196	R:R:F242	R:R:L202	2.44	No	No	0	9	6
197	R:R:I287	R:R:Y288	2.42	No	Yes	2	8	9
198	R:R:Q15	R:R:R99	2.34	No	No	0	2	2
199	R:R:L72	R:R:Y288	2.34	No	Yes	0	8	9
200	R:R:L81	R:R:W156	2.28	No	Yes	0	7	9
201	L:L:?1	R:R:I197	2.16	Yes	No	0	0	5
202	R:R:G163	R:R:G164	2.11	No	No	1	6	4
203	R:R:G163	R:R:P166	2.03	No	Yes	1	6	5
204	R:R:G164	R:R:P166	2.03	No	Yes	1	4	5
205	R:R:C44	R:R:G83	1.96	No	No	0	6	8
206	R:R:A76	R:R:G73	1.95	No	No	0	9	6
207	R:R:C264	R:R:P265	1.88	No	No	0	2	3
208	R:R:G141	R:R:S66	1.86	No	No	0	4	7
209	R:R:G94	R:R:T97	1.82	No	No	0	5	5
210	R:R:C146	R:R:S145	1.72	No	No	0	3	3
211	R:R:C44	R:R:V87	1.71	No	No	0	6	6
212	R:R:G73	R:R:L55	1.71	No	No	0	6	7
213	R:R:G141	R:R:L139	1.71	No	No	0	4	5
214	R:R:C214	R:R:V210	1.71	No	No	0	3	4
215	R:R:C245	R:R:V276	1.71	No	No	0	8	7
216	R:R:G169	R:R:N171	1.7	No	No	0	5	6
217	R:R:A85	R:R:T115	1.68	No	No	0	6	7
218	R:R:K13	R:R:P102	1.67	No	No	0	3	2
219	R:R:C193	R:R:I197	1.64	No	No	0	5	5
220	R:R:S119	R:R:S78	1.63	No	No	0	9	8
221	R:R:S119	R:R:S122	1.63	No	No	0	9	8
222	R:R:S32	R:R:V35	1.62	No	No	0	4	5
223	R:R:A275	R:R:I40	1.62	No	No	0	5	6
224	R:R:A107	R:R:I167	1.62	No	No	0	4	4
225	R:R:S32	R:R:T31	1.6	No	No	0	4	3
226	R:R:V48	R:R:V49	1.6	No	No	0	6	4
227	R:R:V206	R:R:V210	1.6	No	No	0	5	4
228	R:R:T101	R:R:V103	1.59	No	No	0	6	1
229	R:R:G174	R:R:H175	1.59	No	No	0	4	3
230	R:R:A46	R:R:L282	1.58	No	No	0	4	6
231	R:R:A204	R:R:L124	1.58	No	No	0	6	7
232	R:R:F113	R:R:G110	1.51	Yes	No	0	5	6
233	R:R:A178	R:R:E177	1.51	No	No	0	2	3
234	R:R:L91	R:R:V87	1.49	No	No	0	6	6
235	R:R:L157	R:R:V161	1.49	No	No	0	4	3
236	R:R:L203	R:R:V206	1.49	No	No	0	3	5
237	R:R:L231	R:R:V235	1.49	No	No	0	8	8
238	R:R:L72	R:R:T289	1.47	No	No	0	8	7
239	R:R:D143	R:R:S142	1.47	No	No	0	4	4
240	R:R:I200	R:R:I201	1.47	No	No	0	4	7
241	R:R:L231	R:R:T228	1.47	No	No	0	8	6
242	R:R:I243	R:R:L202	1.43	No	No	0	5	6
243	R:R:Q227	R:R:T228	1.42	No	No	0	5	6
244	R:R:L149	R:R:M148	1.41	No	Yes	0	1	7
245	R:R:P265	R:R:Y268	1.39	No	No	0	3	3
246	R:R:L80	R:R:L81	1.38	No	No	0	6	7
247	R:R:D256	R:R:K188	1.38	Yes	No	0	5	4
248	R:R:E16	R:R:K13	1.35	No	No	0	1	3
249	R:R:L98	R:R:Q15	1.33	Yes	No	0	4	2
250	R:R:A36	R:R:Y272	1.33	No	No	0	4	4
251	R:R:H189	R:R:K188	1.31	No	No	0	5	4
252	R:R:R211	R:R:V215	1.31	No	No	0	5	5
253	R:R:E16	R:R:Q15	1.27	No	No	0	1	2
254	R:R:V191	R:R:Y257	1.26	No	No	0	5	4
255	R:R:Q34	R:R:R33	1.17	No	Yes	0	3	5
256	R:R:N61	R:R:Y69	1.16	No	No	0	7	9
257	R:R:L100	R:R:W105	1.14	No	Yes	0	6	8
258	R:R:F64	R:R:H65	1.13	No	No	0	9	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y18	7.92	4	0	7
2	R:R:R33	6.218	5	1	5
3	R:R:F71	6.115	6	0	8
4	R:R:L75	4.97	4	2	9
5	R:R:D79	6.625	4	0	9
6	R:R:T90	4.1575	4	0	6
7	R:R:L98	3.9875	4	0	4
8	R:R:W105	9.29	7	1	8
9	R:R:F106	5.9925	4	1	5
10	R:R:R108	7.056	5	1	6
11	R:R:E109	12.92	4	1	5
12	R:R:F113	5.436	5	0	5
13	R:R:F121	5.68	4	0	5
14	R:R:Y140	5.8	4	0	8
15	R:R:M148	4.764	5	0	7
16	R:R:W156	4.53	4	5	9
17	R:R:P166	5.535	4	1	5
18	R:R:V182	3.8525	4	3	4
19	R:R:L185	6.8	5	1	3
20	R:R:Y186	6.898	5	1	5
21	R:R:Y190	7.72	4	1	6
22	R:R:F198	6.285	4	1	7
23	R:R:Y209	6.064	5	2	9
24	R:R:W246	6.46375	8	1	8
25	R:R:D256	4.272	5	3	5
26	R:R:L267	4.5825	4	3	3
27	R:R:N284	4.9775	4	2	9
28	R:R:Y288	4.23143	7	2	9
29	L:L:?1	5.41231	13	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E16	R:R:K13	10.5311	1.35	No	No	0	1	3
2	R:R:E16	R:R:Q15	12.5935	1.27	No	No	0	1	2
3	R:R:L98	R:R:Q15	16.673	1.33	Yes	No	0	4	2
4	R:R:L185	R:R:W105	18.7656	10.25	Yes	Yes	1	3	8
5	R:R:H17	R:R:L185	16.6805	6.43	No	Yes	0	7	3
6	L:L:?1	R:R:L98	22.981	6.29	Yes	Yes	0	0	4
7	L:L:?1	R:R:W246	93.9639	6.04	Yes	Yes	1	0	8
8	R:R:N280	R:R:W246	100	7.91	No	Yes	0	9	8
9	R:R:N280	R:R:N284	97.3408	6.81	No	Yes	0	9	9
10	R:R:L75	R:R:N284	44.2472	4.12	Yes	Yes	2	9	9
11	R:R:D79	R:R:L75	46.71	2.71	Yes	Yes	0	9	9
12	R:R:D79	R:R:S281	36.0958	5.89	Yes	No	0	9	9
13	R:R:S281	R:R:T278	24.7715	4.8	No	No	4	9	7
14	R:R:F86	R:R:T278	22.8602	2.59	No	No	0	7	7
15	R:R:F86	R:R:T90	11.8154	2.59	No	Yes	0	7	6
16	L:L:?1	R:R:S117	20.6769	5.69	Yes	No	0	0	5
17	R:R:S117	R:R:S159	19.0904	3.26	No	No	0	5	8
18	R:R:A118	R:R:S159	15.2603	3.42	No	No	0	8	8
19	R:R:A118	R:R:W156	11.7927	6.48	No	Yes	5	8	9
20	R:R:L81	R:R:W156	18.9696	2.28	No	Yes	0	7	9
21	R:R:L80	R:R:L81	11.9665	1.38	No	No	0	6	7
22	R:R:L72	R:R:V58	24.6582	2.98	No	No	0	8	7
23	R:R:L72	R:R:Y288	28.3297	2.34	No	Yes	0	8	9
24	R:R:N284	R:R:Y288	88.9099	3.49	Yes	Yes	2	9	9
25	R:R:V58	R:R:Y69	14.8523	5.05	No	No	0	7	9
26	R:R:F71	R:R:M148	13.0165	6.22	Yes	Yes	0	8	7
27	R:R:F71	R:R:I126	46.4758	5.02	Yes	No	0	8	9
28	R:R:I126	R:R:Y288	45.5768	3.63	No	Yes	2	9	9
29	R:R:F71	R:R:M68	12.3744	4.98	Yes	No	0	8	8
30	R:R:M68	R:R:Y140	10.2365	4.79	No	Yes	0	8	8
31	R:R:E129	R:R:F71	16.3783	12.83	No	Yes	0	9	8
32	R:R:E129	R:R:Y140	10.2969	7.86	No	Yes	0	9	8
33	R:R:L75	R:R:S122	20.3596	7.51	Yes	No	0	9	8
34	R:R:L92	R:R:R108	14.7163	4.86	No	Yes	0	4	6
35	R:R:L92	R:R:T97	10.0703	5.9	No	No	0	4	5
36	L:L:?1	R:R:E109	33.6783	7.03	Yes	Yes	1	0	5
37	L:L:?1	R:R:L183	40.6663	4.19	Yes	No	0	0	5
38	R:R:L183	R:R:Y186	12.0798	11.72	No	Yes	0	5	5
39	L:L:?1	R:R:F113	13.772	6.46	Yes	Yes	0	0	5
40	L:L:?1	R:R:F121	15.9628	3.69	Yes	Yes	0	0	5
41	R:R:F121	R:R:I201	10.9164	5.02	Yes	No	0	5	7
42	R:R:A127	R:R:Y209	15.6229	4	No	Yes	0	8	9
43	R:R:Y209	R:R:Y288	39.5331	4.96	Yes	Yes	2	9	9
44	R:R:A127	R:R:L208	13.8551	3.15	No	No	0	8	7
45	R:R:H131	R:R:L208	10.652	6.43	No	No	0	7	7
46	R:R:L183	R:R:V182	42.3963	4.47	No	Yes	0	5	4
47	R:R:T181	R:R:V182	17.368	3.17	No	Yes	3	5	4
48	R:R:D256	R:R:V182	22.2407	4.38	Yes	Yes	3	5	4
49	R:R:L267	R:R:T181	15.6984	5.9	Yes	No	3	3	5
50	R:R:D256	R:R:L267	15.9024	5.43	Yes	Yes	3	5	3
51	L:L:?1	R:R:F274	11.2261	7.38	Yes	No	0	0	6
52	R:R:F274	R:R:L253	12.6539	3.65	No	No	0	6	6
53	R:R:L253	R:R:V191	10.5386	2.98	No	No	0	6	5
54	R:R:T236	R:R:Y209	15.706	3.75	No	Yes	0	6	9
55	R:R:L239	R:R:Y209	11.1506	9.38	No	Yes	0	7	9
56	R:R:L232	R:R:T236	13.4472	4.42	No	No	0	7	6
57	R:R:I287	R:R:Y288	10.2062	2.42	No	Yes	2	8	9
58	R:R:C245	R:R:N280	13.4774	3.15	No	No	0	8	9
59	R:R:C259	R:R:L255	21.2057	3.17	No	No	0	4	5
60	R:R:L255	R:R:L267	24.6884	4.15	No	Yes	0	5	3
61	R:R:C259	R:R:C264	10.6217	7.28	No	No	6	4	2
62	R:R:S66	R:R:Y140	12.4575	2.54	No	Yes	0	7	8
63	R:R:S119	R:R:S78	17.9119	1.63	No	No	0	9	8
64	R:R:E109	R:R:W105	22.3389	25.08	Yes	Yes	1	5	8
65	R:R:S119	R:R:S122	18.2368	1.63	No	No	0	9	8
66	R:R:S78	R:R:W156	14.0364	3.71	No	Yes	5	8	9
67	R:R:L123	R:R:Y288	19.0451	3.52	No	Yes	2	9	9
68	R:R:L123	R:R:L75	18.9167	5.54	No	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L98	R:R:Y18	4.69	0	Yes	Yes	4	7	1	2
R:R:W105	R:R:Y18	8.68	1	Yes	Yes	8	7	2	2
R:R:K269	R:R:R33	3.71	0	No	Yes	4	5	2	1
R:R:H271	R:R:R33	18.05	1	No	Yes	4	5	1	1
L:L:?1	R:R:R33	5.52	1	Yes	Yes	0	5	0	1
R:R:N89	R:R:R108	4.82	0	No	Yes	5	6	1	2
R:R:A112	R:R:N89	4.69	0	No	No	6	5	2	1
L:L:?1	R:R:N89	8.32	1	Yes	No	0	5	0	1
R:R:L98	R:R:R108	3.64	0	Yes	Yes	4	6	1	2
L:L:?1	R:R:L98	6.29	1	Yes	Yes	0	4	0	1
R:R:R108	R:R:W105	8	1	Yes	Yes	6	8	2	2
R:R:E109	R:R:W105	25.08	1	Yes	Yes	5	8	1	2
R:R:W105	R:R:Y186	3.86	1	Yes	Yes	8	5	2	2
R:R:E109	R:R:R108	13.96	1	Yes	Yes	5	6	1	2
R:R:E109	R:R:Y186	5.61	1	Yes	Yes	5	5	1	2
L:L:?1	R:R:E109	7.03	1	Yes	Yes	0	5	0	1
R:R:F113	R:R:L162	3.65	0	Yes	No	5	5	1	2
R:R:F113	R:R:Y190	10.32	0	Yes	Yes	5	6	1	2
R:R:F113	R:R:V194	5.24	0	Yes	No	5	6	1	2
L:L:?1	R:R:F113	6.46	1	Yes	Yes	0	5	0	1
R:R:L116	R:R:W246	6.83	0	No	Yes	7	8	2	1
R:R:S117	R:R:S159	3.26	0	No	No	5	8	1	2
L:L:?1	R:R:S117	5.69	1	Yes	No	0	5	0	1
R:R:F198	R:R:V120	3.93	1	Yes	No	7	7	1	2
R:R:V120	R:R:W246	4.9	1	No	Yes	7	8	2	1
R:R:F121	R:R:S155	3.96	0	Yes	No	5	7	1	2
R:R:F121	R:R:I158	10.05	0	Yes	No	5	4	1	2
R:R:F121	R:R:I201	5.02	0	Yes	No	5	7	1	2
L:L:?1	R:R:F121	3.69	1	Yes	Yes	0	5	0	1
R:R:L183	R:R:V182	4.47	0	No	Yes	5	4	1	2
R:R:L183	R:R:Y186	11.72	0	No	Yes	5	5	1	2
L:L:?1	R:R:L183	4.19	1	Yes	No	0	5	0	1
R:R:Y186	R:R:Y190	4.96	1	Yes	Yes	5	6	2	2
R:R:F198	R:R:W246	10.02	1	Yes	Yes	7	8	1	1
R:R:F198	R:R:F250	7.5	1	Yes	No	7	6	1	2
L:L:?1	R:R:F198	3.69	1	Yes	Yes	0	7	0	1
R:R:F242	R:R:W246	6.01	0	No	Yes	9	8	2	1
R:R:S277	R:R:W246	7.41	0	No	Yes	7	8	2	1
R:R:N280	R:R:W246	7.91	0	No	Yes	9	8	2	1
L:L:?1	R:R:W246	6.04	1	Yes	Yes	0	8	0	1
R:R:F274	R:R:L253	3.65	0	No	No	6	6	1	2
R:R:K269	R:R:Y272	5.97	0	No	No	4	4	2	2
R:R:H271	R:R:Y272	8.71	1	No	No	4	4	1	2
L:L:?1	R:R:H271	3.9	1	Yes	No	0	4	0	1
R:R:F274	R:R:S277	3.96	0	No	No	6	7	1	2
L:L:?1	R:R:F274	7.38	1	Yes	No	0	6	0	1
R:R:R33	R:R:S93	2.64	1	Yes	No	5	5	1	2
R:R:A249	R:R:W246	2.59	0	No	Yes	6	8	2	1
L:L:?1	R:R:I197	2.16	1	Yes	No	0	5	0	1
R:R:C193	R:R:I197	1.64	0	No	No	5	5	2	1
R:R:F113	R:R:G110	1.51	0	Yes	No	5	6	1	2
R:R:L98	R:R:Q15	1.33	0	Yes	No	4	2	1	2
R:R:Q34	R:R:R33	1.17	0	No	Yes	3	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7T6B_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	236
Number of Links	258
Number of Hubs	29
Number of Links mediated by Hubs	115
Number of Communities	6
Number of Nodes involved in Communities	39
Number of Links involved in Communities	51

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	32170
Length Of Smallest Path	3
Average Path Length	10.3136
Length of Longest Path	21
Minimum Path Strength	1.3
Average Path Strength	5.26413
Maximum Path Strength	16.55
Minimum Path Correlation	0.7
Average Path Correlation	0.914363
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	6.25
Average % Of Corr. Nodes	52.6118
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.4101
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • D5 dopamine receptor binding • nucleoside-triphosphatase regulator activity • GTPase regulator activity • guanyl-nucleotide exchange factor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal process • system process • circulatory system process • regulation of blood pressure • blood circulation • developmental process • cellular developmental process • cell differentiation • regulation of vascular associated smooth muscle cell migration • negative regulation of locomotion • vascular associated smooth muscle cell migration • regulation of cell motility • negative regulation of vascular associated smooth muscle cell migration • regulation of smooth muscle cell migration • negative regulation of biological process • smooth muscle cell migration • muscle cell migration • negative regulation of smooth muscle cell migration • regulation of locomotion • regulation of cell migration • negative regulation of cellular process • negative regulation of cell motility • locomotion • negative regulation of cell migration • regulation of fibroblast migration • fibroblast migration • ameboidal-type cell migration • multicellular organism development • embryo development ending in birth or egg hatching • chordate embryonic development • anatomical structure development • embryo development • in utero embryonic development • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of developmental process • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • regulation of anatomical structure morphogenesis • regulation of body fluid levels • wound healing • cell activation • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • platelet activation • branching morphogenesis of an epithelial tube • angiogenesis • tube morphogenesis • epithelial tube morphogenesis • blood vessel development • system development • epithelium development • blood vessel morphogenesis • tube development • morphogenesis of an epithelium • tissue development • vasculature development • circulatory system development • branching involved in blood vessel morphogenesis • tissue morphogenesis • morphogenesis of a branching structure • anatomical structure formation involved in morphogenesis • morphogenesis of a branching epithelium • cellular component biogenesis • cellular component assembly • regulation of postsynapse assembly • cell junction assembly • regulation of synapse structure or activity • synapse organization • regulation of synapse assembly • postsynapse organization • postsynapse assembly • regulation of postsynapse organization • nervous system development • regulation of cellular component biogenesis • regulation of cell junction assembly • regulation of synapse organization • cell junction organization • synapse assembly • Rho-activating G protein-coupled receptor signaling pathway • regulation of signaling • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • regulation of signal transduction • intracellular signal transduction • regulation of intracellular signal transduction • regulation of response to stimulus • intracellular signaling cassette • regulation of cell communication • Rho protein signal transduction • regulation of vascular associated smooth muscle cell proliferation • negative regulation of cell population proliferation • cell population proliferation • regulation of smooth muscle cell proliferation • negative regulation of vascular associated smooth muscle cell proliferation • smooth muscle cell proliferation • negative regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • anchoring junction • cell junction • focal adhesion • cell-substrate junction • pigment granule • intracellular vesicle • melanosome • cytoplasmic vesicle • brush border membrane • cluster of actin-based cell projections • brush border • plasma membrane region • cell projection membrane • postsynapse • synapse • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • bioactive lipid receptor activity • sphingosine-1-phosphate receptor activity • cell adhesion molecule binding • integrin binding • signaling receptor binding • lipid binding • peptide receptor activity • G protein-coupled peptide receptor activity • G protein-coupled receptor binding • positive regulation of phosphorylation • regulation of protein modification process • regulation of protein phosphorylation • positive regulation of protein metabolic process • positive regulation of biological process • regulation of peptidyl-threonine phosphorylation • positive regulation of phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • positive regulation of protein modification process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • peptidyl-amino acid modification • positive regulation of macromolecule metabolic process • protein metabolic process • peptidyl-threonine modification • positive regulation of protein phosphorylation • phosphorus metabolic process • protein modification process • positive regulation of cellular process • protein phosphorylation • positive regulation of phosphorus metabolic process • positive regulation of peptidyl-threonine phosphorylation • phosphorylation • regulation of protein metabolic process • primary metabolic process • regulation of macromolecule metabolic process • macromolecule modification • regulation of phosphorus metabolic process • metabolic process • regulation of phosphorylation • macromolecule metabolic process • regulation of metabolic process • peptidyl-threonine phosphorylation • cellular component organization • organelle organization • actin cytoskeleton organization • actin filament-based process • cellular component organization or biogenesis • cytoskeleton organization • positive regulation of cell population proliferation • regulation of cell population proliferation • regulation of postsynaptic membrane potential • chemical synaptic transmission, postsynaptic • regulation of biological quality • trans-synaptic signaling • cell surface receptor signaling pathway • chemical synaptic transmission • anterograde trans-synaptic signaling • excitatory postsynaptic potential • regulation of membrane potential • regulation of cellular component organization • cellular component biogenesis • cellular component assembly • regulation of postsynapse assembly • cell junction assembly • regulation of synapse structure or activity • synapse organization • regulation of synapse assembly • postsynapse organization • postsynapse assembly • regulation of postsynapse organization • nervous system development • regulation of cellular component biogenesis • regulation of cell junction assembly • regulation of synapse organization • cell junction organization • synapse assembly • filopodium assembly • plasma membrane bounded cell projection organization • cell projection organization • plasma membrane bounded cell projection assembly • cell projection assembly • modulation of chemical synaptic transmission • regulation of system process • negative regulation of biological process • regulation of signal transduction • modulation of excitatory postsynaptic potential • regulation of multicellular organismal process • regulation of signaling • regulation of nervous system process • regulation of trans-synaptic signaling • regulation of response to stimulus • negative regulation of excitatory postsynaptic potential • regulation of cell communication • regulation of establishment of endothelial barrier • cellular developmental process • regulation of developmental process • positive regulation of endothelial cell development • endothelium development • cell development • regulation of cell differentiation • epithelial cell differentiation • regulation of cell development • regulation of epithelial cell differentiation • endothelial cell development • positive regulation of developmental process • positive regulation of cell differentiation • cell differentiation • regulation of endothelial cell development • epithelium development • regulation of multicellular organismal development • endothelial cell differentiation • regulation of endothelial cell differentiation • positive regulation of cell development • positive regulation of establishment of endothelial barrier • tissue development • epithelial cell development • establishment of endothelial barrier • sphingolipid mediated signaling pathway • sphingosine-1-phosphate receptor signaling pathway • presynapse • glutamatergic synapse
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	S1P
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	S1P
Name	(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate
Synonyms	sphingosine 1-phosphate
Identifier
Formula	C18 H38 N O5 P
Molecular Weight	379.472
SMILES
PubChem	10883396
Formal Charge	0
Total Atoms	63
Total Chiral Atoms	2
Total Bonds	62
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O95136
Sequence	>7T6B_nogp_Chain_R N K V Q E H Y N Y T K T S R Q V A S A F I V I L C C A I V V E N L L V L I A V A R N S K F H S A M Y L F L G N L A A S D L L A G V A F V A N T L L S G S V T L R L T P V Q W F A R E G S A F I T L S A S V F S L L A I A I E R H V A I A K V K L Y G S D K S C R M L L L I G A S W L I S L V L G G L P I L G W N C L G H L E A C S T V L P L Y A K H Y V L C V V T I F S I I L L A I V A L Y V R I Y C V V R S S Q T L A L L K T V T I V L G V F I V C W L P A F S I L L L D Y A C P V H S C P I L Y K A H Y F F A V S T L N S L L N P V I Y T W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7T6B	A	Lipid	Lysophospholipid	S1P₂	Homo sapiens	S1P	-	chim(NtGi1L-G13)/β1/γ2	3.19	2022-04-06	10.1126/sciadv.abn0067
	7T6B (No Gprot)	A	Lipid	Lysophospholipid	S1P₂	Homo sapiens	S1P	-		3.19	2022-04-06	10.1126/sciadv.abn0067

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