Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:L402 7.48754139
2R:R:L403 5.5075478
3R:R:Q408 7.75667678
4R:R:W413 4.9475409
5R:R:T419 3.26408
6R:R:N423 5.764529
7R:R:R430 8.01857709
8R:R:Y440 6.608527
9R:R:D451 5.152529
10R:R:M454 4.55409
11R:R:Y457 7.6175409
12R:R:F468 11.335407
13R:R:W479 7.191676139
14R:R:Q486 4.785426
15R:R:V488 3.285406
16R:R:V498 4.69508
17R:R:L501 4.255407
18R:R:K510 7.026529
19R:R:Y511 7.2885145
20R:R:V515 8.90754147
21R:R:P546 11.666529
22R:R:F553 8.635428
23R:R:Y556 7.73714727
24R:R:Y557 8.226529
25R:R:F564 5.62628
26R:R:P565 6.525428
27R:R:L566 4.275629
28R:R:Y579 8.685429
29R:R:F584 4.975428
30R:R:N588 5.735429
31R:R:Y599 5.726529
32R:R:W641 7.836529
33R:R:F645 4.3575408
34R:R:I657 4.0275478
35R:R:I661 4.3825476
36R:R:W664 9.55478
37R:R:I667 4.875478
38R:R:F668 6.7325479
39R:R:L670 4.8875429
40R:R:N677 5.5375429
41R:R:Y681 5.294529
42R:R:R686 4.9025405
43A:A:Y37 6.37714
44A:A:L43 4.03647
45A:A:L44 6.865419
46A:A:L45 4.516548
47A:A:S51 2.89409
48A:A:I56 3.2525447
49A:A:V57 6.914177
50A:A:M60 3.926509
51A:A:F219 7.07333648
52A:A:M221 3.745408
53A:A:Q227 5.59519
54A:A:E230 9.95519
55A:A:K233 7.234519
56A:A:W234 4.39667619
57A:A:F238 5.145619
58A:A:I244 6.11418
59A:A:I245 5.4225447
60A:A:Y253 5.778508
61A:A:L270 4.356536
62A:A:F273 7.958539
63A:A:W277 11.915436
64A:A:W281 6.73143715
65A:A:L282 5.955419
66A:A:I288 3.91409
67A:A:L289 6.9425439
68A:A:F290 5.382549
69A:A:L291 4.8275438
70A:A:N292 4.3425449
71A:A:F315 15.235406
72A:A:Y318 9.5075406
73A:A:E327 5.0925404
74A:A:V334 3.405404
75A:A:K338 7.056535
76A:A:Y339 5.53667633
77A:A:F340 14.1407
78A:A:Y360 9.07754188
79A:A:F363 9.492535
80A:A:R373 4.302545
81A:A:F376 7.71667648
82A:A:Y391 7.3125424
83A:A:L394 3.96408
84B:B:T50 5.215463
85B:B:L51 9.3025409
86B:B:H54 8.1745119
87B:B:M61 4.0725496
88B:B:W63 7.54143797
89B:B:R68 8.205405
90B:B:V71 5.7425488
91B:B:S72 5.6454119
92B:B:Q75 9.685419
93B:B:D76 7.12519
94B:B:K78 5.73408
95B:B:L79 4.705487
96B:B:I80 5.057118
97B:B:I81 3.85587
98B:B:W82 10.5245119
99B:B:K89 6.975119
100B:B:L95 5.808588
101B:B:W99 6.60333619
102B:B:C103 3.855488
103B:B:Y105 5.345686
104B:B:L117 6.285619
105B:B:I123 4.012516
106B:B:Y124 5.195406
107B:B:H142 5.75571719
108B:B:Y145 8.05714718
109B:B:F151 7.094509
110B:B:L152 3.9725403
111B:B:V158 4.8425405
112B:B:T159 5.205419
113B:B:S161 6.675419
114B:B:D163 7.86409
115B:B:L168 5.335406
116B:B:W169 6.76618
117B:B:Q176 5.41414
118B:B:F180 8.1025107
119B:B:H183 6.7265109
120B:B:D186 8.384519
121B:B:V187 3.54109
122B:B:L190 4.915405
123B:B:V200 7.85456
124B:B:S201 3.5125109
125B:B:C204 4.892517
126B:B:K209 7.88406
127B:B:L210 3.805455
128B:B:W211 8.595108
129B:B:R219 7.425455
130B:B:Q220 4.705457
131B:B:F222 4.725458
132B:B:H225 7.92667659
133B:B:D228 9.105419
134B:B:I229 6.27457
135B:B:I232 7.3775458
136B:B:F235 7.0745156
137B:B:F241 8.134556
138B:B:T243 8.2525458
139B:B:D247 6.6875409
140B:B:F253 7.255656
141B:B:D254 4.715409
142B:B:Y264 5.2985125
143B:B:C271 4.525415
144B:B:F278 6.4025157
145B:B:Y289 9.926507
146B:B:D290 5.662516
147B:B:C294 4.505465
148B:B:V296 4.582505
149B:B:W297 8.964128
150B:B:L308 6.2825467
151B:B:H311 11.2775469
152B:B:R314 11.136518
153B:B:L318 3.932566
154B:B:V327 3.774566
155B:B:T329 5.4825468
156B:B:W332 9.34857719
157B:B:F335 7.2125464
158B:B:K337 9.972566
159B:B:W339 6.87667669
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F564 R:R:Y457 12.13984.13YesYes089
2R:R:M454 R:R:Y457 18.27715.99YesYes099
3R:R:M454 R:R:S674 19.49936.13YesNo099
4R:R:D451 R:R:S674 20.63318.83YesNo099
5R:R:K510 R:R:Y681 51.99144.78YesYes299
6R:R:N677 R:R:Y681 51.0235.81YesYes299
7R:R:D451 R:R:N677 25.44464.04YesYes299
8A:A:L46 A:A:R231 10.06743.64NoNo089
9A:A:L272 A:A:R231 99.99969.72NoNo089
10A:A:F246 A:A:L272 1007.31NoNo098
11A:A:F246 A:A:F273 99.99889.65NoYes099
12A:A:F273 A:A:L289 98.78179.74YesYes399
13A:A:L289 A:A:L291 98.77964.15YesYes398
14A:A:L291 A:A:S250 98.25946.01YesNo386
15A:A:L297 A:A:S250 98.34984.5NoNo086
16A:A:L297 A:A:Y253 98.84683.52NoYes088
17A:A:K300 A:A:Y253 99.92259.55NoYes098
18A:A:K300 A:A:S251 99.91846.12NoNo099
19A:A:L296 A:A:S251 99.89757.51NoNo069
20A:A:K293 A:A:L296 99.893214.1NoNo096
21A:A:K293 A:A:N292 99.8572.8NoYes099
22A:A:I56 A:A:N292 25.43232.83YesYes479
23A:A:I56 A:A:L45 24.93894.28YesYes478
24A:A:I245 A:A:L45 49.12615.71YesYes478
25A:A:I245 A:A:L43 49.12577.14YesYes477
26A:A:F219 A:A:L43 72.7893.65YesYes487
27A:A:F219 A:A:F376 72.1177.5YesYes488
28A:A:F376 A:A:R380 95.88729.62YesNo087
29A:A:R380 R:R:P517 95.69442.88NoNo078
30A:A:Q384 R:R:P517 95.50166.32NoNo068
31A:A:Q384 R:R:I514 95.30884.12NoNo068
32R:R:I514 R:R:M602 89.75457.29NoNo089
33R:R:K510 R:R:M602 59.79122.88YesNo099
34A:A:N292 A:A:V247 24.97724.43YesNo497
35A:A:L45 A:A:V247 24.93832.98YesNo487
36A:A:N292 A:A:T364 49.45037.31YesNo099
37A:A:F290 A:A:T364 49.280110.38YesNo099
38A:A:F290 A:A:I375 24.60365.02YesNo499
39A:A:I375 A:A:L43 24.56432.85NoYes497
40A:A:F290 A:A:R374 24.19763.21YesNo494
41A:A:E370 A:A:R374 24.169115.12NoNo044
42A:A:E370 A:A:R373 24.12933.49NoYes045
43A:A:F376 A:A:R373 23.93773.21YesYes485
44B:B:L318 B:B:S275 10.54043YesNo068
45B:B:S275 B:B:T274 10.71773.2NoNo088
46B:B:R314 B:B:T274 10.894918.11YesNo088
47A:A:Q236 B:B:R314 14.89857.01NoYes188
48A:A:K233 A:A:Q236 26.40835.42YesNo198
49A:A:K233 B:B:M188 41.34845.76YesNo098
50B:B:M188 B:B:Y145 60.41137.18NoYes088
51A:A:W234 B:B:Y145 80.43675.79YesYes198
52A:A:R231 A:A:W234 90.0295NoYes099
53B:B:R314 B:B:W332 14.269413.99YesYes189
54R:R:I545 R:R:P546 11.5413.39NoYes059
55R:R:P565 R:R:Y556 11.760712.52YesYes287
56R:R:F564 R:R:P565 24.13174.33YesYes288
57R:R:P565 R:R:Y557 11.13554.17YesYes289
58R:R:F584 R:R:N588 45.15234.83YesYes289
59R:R:F564 R:R:F584 23.81836.43YesYes288
60R:R:N588 R:R:W641 45.5096.78YesYes299
61R:R:D637 R:R:I595 23.92914.2NoNo098
62R:R:D637 R:R:W641 23.32595.58NoYes099
63R:R:I595 R:R:T507 27.82834.56NoNo089
64R:R:M602 R:R:S598 29.81463.07NoNo098
65R:R:S598 R:R:T507 28.00694.8NoNo089
66R:R:L566 R:R:T662 12.03624.42YesNo097
67R:R:H567 R:R:I657 10.37983.98NoYes088
68R:R:N673 R:R:N677 25.44756.81NoYes299
69R:R:N673 R:R:W641 23.389410.17NoYes299
70B:B:R68 B:B:Y85 18.561611.32YesNo054
71B:B:S84 B:B:Y85 19.23755.09NoNo054
72B:B:S84 B:B:W63 19.57694.94NoYes957
73B:B:M61 B:B:W63 22.31683.49YesYes967
74B:B:L336 B:B:M61 23.34382.83NoYes076
75B:B:L336 B:B:S72 23.6756.01NoYes079
76B:B:H54 B:B:S72 11.99919.76YesYes1199
77B:B:H54 B:B:S74 12.676911.16YesNo099
78B:B:D76 B:B:S74 12.8468.83YesNo099
79A:A:Y37 B:B:D76 28.74375.75YesYes149
80A:A:F238 A:A:V241 10.00665.24YesNo099
81A:A:F238 A:A:W234 10.31054.01YesYes199
82B:B:I80 B:B:S72 12.01033.1YesYes1189
83B:B:I80 B:B:K78 14.74244.36YesYes088
84B:B:D76 B:B:K78 15.75775.53YesYes098
85A:A:Y37 B:B:Q75 14.63794.51YesYes149
86B:B:D186 B:B:Y145 19.42114.94YesYes198
87B:B:C204 B:B:D186 19.48133.11YesYes179
88B:B:C204 B:B:M188 19.10413.24YesNo078
89A:A:K233 B:B:D228 30.518.3YesYes199
90B:B:C204 B:B:D228 38.37210.89YesYes179
91A:A:K233 B:B:D246 30.43048.3YesNo199
92B:B:K57 B:B:W332 14.745225.53NoYes199
93B:B:L152 B:B:V158 22.37937.45YesYes035
94B:B:L152 B:B:V213 30.85832.98YesNo034
95B:B:R214 B:B:V213 77.91527.85NoNo094
96B:B:R197 B:B:R214 78.68437.46NoNo059
97B:B:D195 B:B:R197 79.453417.87NoNo055
98B:B:A193 B:B:D195 80.22243.09NoNo045
99B:B:A193 B:B:F234 82.52936.93NoNo045
100B:B:F234 B:B:V200 84.83576.55NoYes056
101B:B:I232 B:B:V200 58.01396.14YesYes586
102B:B:I232 B:B:T243 59.036412.16YesYes588
103B:B:H225 B:B:T243 29.77319.58YesYes598
104B:B:H225 B:B:S245 66.977312.55YesNo599
105B:B:D247 B:B:S245 97.5065.89YesNo099
106B:B:D247 B:B:S227 98.76232.94YesNo096
107B:B:D228 B:B:S227 68.64232.94YesNo096
108B:B:L168 B:B:V158 22.37914.47YesYes065
109B:B:L168 B:B:V213 46.28832.98YesNo064
110B:B:F241 B:B:V200 29.110915.73YesYes566
111B:B:F241 B:B:F253 29.57511.79YesYes566
112B:B:F253 B:B:H225 36.44779.05YesYes569
113B:B:I229 B:B:T243 29.77426.08YesYes578
114B:B:I229 B:B:S245 30.28086.19YesNo579
115B:B:D246 B:B:S227 30.36822.94NoNo096
116B:B:L69 B:B:R68 16.16313.64NoYes055
117B:B:L190 B:B:V158 38.5892.98YesYes055
118B:B:D153 B:B:N155 10.81464.04NoNo053
119B:B:D153 B:B:Q156 12.359311.75NoNo055
120B:B:L190 B:B:S160 10.806110.51YesNo056
121B:B:L190 B:B:S201 23.15673YesYes059
122B:B:F180 B:B:T178 14.66476.49YesNo074
123B:B:L168 B:B:T178 16.20775.9YesNo064
124B:B:F180 B:B:W211 11.578215.03YesYes1078
125B:B:H183 B:B:S201 13.89334.18YesYes1099
126B:B:A203 B:B:V187 12.34963.39NoYes1089
127B:B:D205 B:B:G185 10.80641.68NoNo095
128B:B:A203 B:B:G185 16.20951.95NoNo085
129R:R:H567 R:R:T662 11.20754.11NoNo087
130R:R:F584 R:R:L566 14.78224.87YesYes289
131A:A:W281 B:B:W332 10.90712.81YesYes159
132A:A:Q236 A:A:W281 11.47186.57NoYes185
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7TMW
Class A
SubFamily Peptide
Type Relaxin
SubType RXFP1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.2
Date 2023-02-15 
D.O.I. 10.1101/2022.01.22.477343
Net Summary
Imin 2.8
Number of Linked Nodes 768
Number of Links 948
Number of Hubs 159
Number of Links mediated by Hubs 584
Number of Communities 21
Number of Nodes involved in Communities 234
Number of Links involved in Communities 343
Path Summary
Number Of Nodes in MetaPath 133
Number Of Links MetaPath 132
Number of Shortest Paths 5884719
Length Of Smallest Path 3
Average Path Length 46.9376
Length of Longest Path 70
Minimum Path Strength 1.375
Average Path Strength 6.64556
Maximum Path Strength 24.62
Minimum Path Correlation 0.7
Average Path Correlation 0.993807
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.75439
Average % Of Corr. Nodes 32.5615
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.6118
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ9HBX9
Sequence
>7TMW_Chain_R
ENLLASIIQ RVFVWVVSA VTCFGNIFV ICMRPYIEN KLYAMSIIS 
LCCADCLMG IYLFVIGGF DLKFRGEYN KHAQLWMES THCQLVGSL 
AILSTEVSV LLLTFLTLE KYICIVYPP GKCRTITVL ILIWITGFI 
VAFIPLSNK EFFKNYYGT NGVCFPLHE SIGAQIYSV AIFLGINLA 
AFIIIVFSY GSMFYSVHQ EMILAKRFF FIVFTDALC WIPIFVVKF 
LSLLQVEIP GTITSWVVI FILPINSAL NPILYTLTT RPFKEMIHR 
FWYNY


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7TMW_Chain_A
QRNEEKAQR EANKKIEKQ LQKDKQVYR ATHRLLLLG ADNSGKSTI 
VKQMRIYFE TKFQVDKVN FHMFDVGGQ RDERRKWIQ CFNDVTAII 
FVVDSSDYN RLQEALNLF KSIWNNRWL RTISVILFL NKQDLLAEK 
VLAGKSKIE DYFPEFARY TTPEDATPE PGEDPRVTR AKYFIRDEF 
LRISTAHYC YPHFTCAVD TENARRIFN DCRDIIQRM HLRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7TMW_Chain_B
GRIQMRTRR TLRGHLAKI YAMHWGTDS RLLVSASQD GKLIIWDSY 
TTNKVHAIP LRSSWVMTC AYAPSGNYV ACGGLDNIC SIYNLKTRE 
GNVRVSREL AGHTGYLSC CRFLDDNQI VTSSGDTTC ALWDIETGQ 
QTTTFTGHT GDVMSLSLA PDTRLFVSG ACDASAKLW DVREGMCRQ 
TFTGHESDI NAICFFPNG NAFATGSDD ATCRLFDLR AELMTYSHD 
NIICGITSV SFSKSGRLL LAGYDDFNC NVWDALKAD RAGVLAGHD 
NRVSCLGVT DDGMAVATG SWDSFLKIW N


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7TMW_Chain_G
EDPLLTP


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7TMWAPeptideRelaxinRXFP1Homo sapiens--Gs/&β;1/&γ;23.22023-02-1510.1101/2022.01.22.477343




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7TMW.zip



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