psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E400	R:R:N473	3.94	No	No	0	7	7
2	R:R:N401	R:R:R469	3.62	No	No	0	7	7
3	R:R:D465	R:R:L402	10.86	No	Yes	0	9	9
4	R:R:L402	R:R:Y472	10.55	Yes	No	2	9	9
5	R:R:L402	R:R:W479	6.83	Yes	Yes	2	9	9
6	R:R:L403	R:R:Q408	3.99	No	Yes	0	8	8
7	R:R:D465	R:R:L403	12.21	No	No	0	9	8
8	R:R:Q408	R:R:S405	4.33	Yes	No	0	8	7
9	R:R:I406	R:R:R409	7.52	No	No	0	3	9
10	R:R:I407	R:R:Q408	6.86	No	Yes	0	5	8
11	R:R:F411	R:R:I407	6.28	No	No	0	5	5
12	R:R:Q408	R:R:W664	15.33	Yes	Yes	3	8	8
13	R:R:I667	R:R:Q408	5.49	No	Yes	3	8	8
14	R:R:F668	R:R:Q408	10.54	Yes	Yes	3	9	8
15	R:R:R409	R:R:W413	4	No	Yes	0	9	9
16	R:R:F411	R:R:V410	3.93	No	No	0	5	5
17	R:R:F411	R:R:F668	5.36	No	Yes	0	5	9
18	R:R:I667	R:R:V412	6.14	No	No	0	8	8
19	R:R:F459	R:R:W413	5.01	No	Yes	0	6	9
20	R:R:L466	R:R:W413	7.97	No	Yes	0	3	9
21	R:R:P671	R:R:V415	3.53	No	No	0	9	7
22	R:R:F459	R:R:S416	3.96	No	No	0	6	8
23	R:R:G455	R:R:T419	3.64	No	No	0	8	8
24	R:R:S674	R:R:T419	4.8	No	No	0	9	8
25	R:R:G422	R:R:P678	4.06	No	No	0	8	9
26	R:R:C448	R:R:N423	6.3	No	Yes	0	8	9
27	R:R:D451	R:R:N423	6.73	No	Yes	0	9	9
28	R:R:C452	R:R:N423	4.72	No	Yes	0	7	9
29	R:R:N423	R:R:P678	8.15	Yes	No	0	9	9
30	R:R:F425	R:R:M429	9.95	No	Yes	0	4	6
31	R:R:F425	R:R:F688	6.43	No	Yes	0	4	8
32	R:R:C448	R:R:V426	6.83	No	No	0	8	9
33	R:R:T682	R:R:V426	7.93	No	No	0	9	9
34	R:R:M429	R:R:Y432	3.59	Yes	No	4	6	3
35	R:R:M429	R:R:M691	7.22	Yes	Yes	4	6	5
36	R:R:I433	R:R:R430	10.02	No	Yes	0	4	9
37	R:R:I444	R:R:R430	20.04	No	Yes	0	9	9
38	R:R:I445	R:R:R430	3.76	No	Yes	0	7	9
39	R:R:R430	R:R:T682	6.47	Yes	No	0	9	9
40	R:R:M691	R:R:Y432	3.59	Yes	No	4	5	3
41	R:R:F695	R:R:Y432	11.35	No	No	4	1	3
42	R:R:I433	R:R:M691	5.83	No	Yes	0	4	5
43	R:R:E436	R:R:P687	4.72	No	No	0	6	5
44	R:R:L439	R:R:N437	4.12	No	No	0	7	8
45	R:R:N437	R:R:Y440	3.49	No	Yes	0	8	7
46	R:R:L439	R:R:T528	13.27	No	No	0	7	8
47	R:R:I444	R:R:Y440	3.63	No	Yes	0	9	7
48	R:R:L506	R:R:Y440	7.03	No	Yes	0	8	7
49	R:R:K510	R:R:Y440	11.94	No	Yes	0	9	7
50	R:R:F505	R:R:S443	5.28	No	No	0	6	7
51	R:R:L506	R:R:S443	7.51	No	No	0	8	7
52	R:R:L502	R:R:S446	10.51	No	No	0	7	8
53	R:R:L532	R:R:S446	7.51	No	No	0	7	8
54	R:R:L447	R:R:L503	5.54	No	No	0	9	9
55	R:R:D451	R:R:S674	8.83	No	No	0	9	9
56	R:R:D451	R:R:N677	4.04	No	Yes	0	9	9
57	R:R:L453	R:R:L491	5.54	No	No	0	7	8
58	R:R:L453	R:R:S495	6.01	No	No	0	7	9
59	R:R:M454	R:R:Y457	5.99	Yes	Yes	0	9	9
60	R:R:M454	R:R:S674	6.13	Yes	No	0	9	9
61	R:R:I461	R:R:Y457	9.67	No	Yes	0	8	9
62	R:R:A492	R:R:Y457	10.68	No	Yes	0	9	9
63	R:R:F564	R:R:Y457	4.13	Yes	Yes	0	8	9
64	R:R:L458	R:R:P671	4.93	No	No	0	9	9
65	R:R:F464	R:R:V460	6.55	No	No	0	6	6
66	R:R:V460	R:R:V488	4.81	No	No	0	6	6
67	R:R:F464	R:R:W479	9.02	No	Yes	0	6	9
68	R:R:F468	R:R:K467	14.89	No	No	0	7	4
69	R:R:F468	R:R:H475	20.36	No	No	0	7	6
70	R:R:W479	R:R:Y472	6.75	Yes	No	2	9	9
71	R:R:H475	R:R:L478	16.71	No	No	0	6	3
72	R:R:S482	R:R:W479	6.18	No	Yes	0	9	9
73	R:R:C485	R:R:W479	6.53	No	Yes	2	9	9
74	R:R:C563	R:R:W479	7.84	No	Yes	2	9	9
75	R:R:H484	R:R:S482	5.58	No	No	0	4	9
76	R:R:C485	R:R:C563	7.28	No	No	2	9	9
77	R:R:K550	R:R:Q486	4.07	No	Yes	1	4	6
78	R:R:N555	R:R:Q486	6.6	No	Yes	1	7	6
79	R:R:Q486	R:R:Y557	5.64	Yes	Yes	1	6	9
80	R:R:L547	R:R:S490	4.5	No	No	0	6	7
81	R:R:S490	R:R:Y557	11.45	No	Yes	0	7	9
82	R:R:I493	R:R:P565	5.08	No	Yes	0	8	8
83	R:R:F540	R:R:L494	7.31	No	No	0	4	7
84	R:R:A543	R:R:L494	4.73	No	No	0	8	7
85	R:R:E497	R:R:L501	3.98	No	No	0	9	7
86	R:R:E497	R:R:I587	5.47	No	No	0	9	5
87	R:R:E497	R:R:N588	3.94	No	Yes	0	9	9
88	R:R:V498	R:R:W536	12.26	Yes	No	0	8	9
89	R:R:N588	R:R:V500	7.39	Yes	No	1	9	8
90	R:R:V500	R:R:W641	4.9	No	Yes	1	8	9
91	R:R:I535	R:R:L501	7.14	No	No	0	7	7
92	R:R:I535	R:R:L502	4.28	No	No	0	7	7
93	R:R:L503	R:R:N677	5.49	No	Yes	1	9	9
94	R:R:L503	R:R:Y681	4.69	No	Yes	1	9	9
95	R:R:I595	R:R:T504	4.56	No	No	0	8	7
96	R:R:F505	R:R:V531	7.87	No	No	0	6	4
97	R:R:I595	R:R:T507	4.56	No	No	0	8	9
98	R:R:S598	R:R:T507	4.8	No	No	0	8	9
99	R:R:T507	R:R:Y599	4.99	No	Yes	0	9	9
100	R:R:I594	R:R:L508	4.28	No	No	0	5	6
101	R:R:K510	R:R:Y599	4.78	No	Yes	0	9	9
102	R:R:K510	R:R:Y681	4.78	No	Yes	0	9	9
103	R:R:V515	R:R:Y511	12.62	Yes	Yes	5	7	5
104	R:R:Y511	R:R:Y516	9.93	Yes	Yes	5	5	7
105	R:R:S598	R:R:Y511	5.09	No	Yes	0	8	5
106	R:R:S601	R:R:Y511	7.63	No	Yes	5	5	5
107	R:R:I514	R:R:M602	7.29	No	No	0	8	9
108	R:R:V515	R:R:Y516	10.09	Yes	Yes	5	7	7
109	R:R:S601	R:R:V515	6.46	No	Yes	5	5	7
110	R:R:S605	R:R:V515	6.46	No	Yes	0	7	7
111	R:R:P523	R:R:R527	4.32	No	No	0	6	6
112	R:R:P523	R:R:T528	3.5	No	No	0	6	8
113	R:R:V542	R:R:Y579	3.79	No	Yes	0	7	9
114	R:R:F544	R:R:L547	7.31	No	No	0	4	6
115	R:R:F553	R:R:P546	18.78	Yes	Yes	1	8	9
116	R:R:P546	R:R:Y556	8.34	Yes	Yes	1	9	7
117	R:R:P546	R:R:Y557	13.91	Yes	Yes	1	9	9
118	R:R:P546	R:R:Y579	13.91	Yes	Yes	1	9	9
119	R:R:F552	R:R:N549	8.46	No	No	0	5	4
120	R:R:K550	R:R:N555	8.39	No	No	1	4	7
121	R:R:F552	R:R:F553	7.5	No	Yes	0	5	8
122	R:R:F553	R:R:Y556	4.13	Yes	Yes	1	8	7
123	R:R:F553	R:R:Y579	4.13	Yes	Yes	1	8	9
124	R:R:K554	R:R:S573	6.12	No	No	0	5	5
125	R:R:Y556	R:R:Y557	5.96	Yes	Yes	1	7	9
126	R:R:P565	R:R:Y556	12.52	Yes	Yes	1	8	7
127	R:R:Y556	R:R:Y579	12.91	Yes	Yes	1	7	9
128	R:R:S580	R:R:Y556	7.63	No	Yes	0	9	7
129	R:R:P565	R:R:Y557	4.17	Yes	Yes	1	8	9
130	R:R:N560	R:R:V562	4.43	No	No	0	9	8
131	R:R:V562	R:R:V666	4.81	No	No	0	8	9
132	R:R:F564	R:R:P565	4.33	Yes	Yes	1	8	8
133	R:R:F564	R:R:L566	4.87	Yes	Yes	1	8	9
134	R:R:F564	R:R:F584	6.43	Yes	Yes	1	8	8
135	R:R:F564	R:R:V666	7.87	Yes	No	1	8	9
136	R:R:F564	R:R:L670	6.09	Yes	Yes	1	8	9
137	R:R:F584	R:R:L566	4.87	Yes	Yes	1	8	9
138	R:R:I644	R:R:L566	4.28	No	Yes	0	8	9
139	R:R:K648	R:R:L566	4.23	No	Yes	0	8	9
140	R:R:L566	R:R:T662	4.42	Yes	No	0	9	7
141	R:R:H567	R:R:S651	6.97	No	No	0	8	9
142	R:R:H567	R:R:I657	3.98	No	No	0	8	8
143	R:R:H567	R:R:T662	4.11	No	No	0	8	7
144	R:R:E572	R:R:Q577	14.02	No	No	0	5	7
145	R:R:K648	R:R:S580	4.59	No	No	0	8	9
146	R:R:L652	R:R:V581	5.96	No	No	0	7	7
147	R:R:F584	R:R:I583	3.77	Yes	No	0	8	7
148	R:R:F584	R:R:N588	4.83	Yes	Yes	1	8	9
149	R:R:N588	R:R:W641	6.78	Yes	Yes	1	9	9
150	R:R:F645	R:R:L589	6.09	Yes	No	0	8	5
151	R:R:D637	R:R:F592	10.75	No	No	0	9	8
152	R:R:D637	R:R:I595	4.2	No	No	0	9	8
153	R:R:I633	R:R:Y599	12.09	No	Yes	0	9	9
154	R:R:V634	R:R:Y599	3.79	No	Yes	0	9	9
155	R:R:F603	R:R:H607	9.05	No	No	0	7	4
156	R:R:Q608	R:R:Y604	4.51	No	No	0	5	3
157	R:R:H607	R:R:Q608	4.95	No	No	0	4	5
158	R:R:E623	R:R:M624	12.18	No	No	0	7	6
159	R:R:F630	R:R:L626	3.65	No	No	0	8	7
160	R:R:F632	R:R:K628	3.72	No	No	0	7	7
161	R:R:R629	R:R:T684	7.76	No	No	0	9	8
162	R:R:R629	R:R:T685	3.88	No	No	0	9	9
163	R:R:F631	R:R:F632	4.29	No	No	0	7	7
164	R:R:I633	R:R:L680	9.99	No	No	0	9	9
165	R:R:F635	R:R:L639	9.74	No	No	0	5	5
166	R:R:L676	R:R:T636	8.84	No	No	0	7	9
167	R:R:D637	R:R:W641	5.58	No	Yes	0	9	9
168	R:R:C640	R:R:W641	11.75	No	Yes	1	9	9
169	R:R:C640	R:R:I672	4.91	No	No	0	9	8
170	R:R:C640	R:R:N673	6.3	No	No	1	9	9
171	R:R:N673	R:R:W641	10.17	No	Yes	1	9	9
172	R:R:F645	R:R:I642	6.28	Yes	No	0	8	7
173	R:R:I644	R:R:L670	5.71	No	Yes	0	8	9
174	R:R:F649	R:R:L653	7.31	No	No	0	5	4
175	R:R:L650	R:R:V655	4.47	No	No	0	6	5
176	R:R:I657	R:R:I661	5.89	No	No	0	8	6
177	R:R:I661	R:R:P658	5.08	No	No	0	6	6
178	R:R:T660	R:R:W664	13.34	No	Yes	0	6	8
179	R:R:I661	R:R:W664	3.52	No	Yes	0	6	8
180	R:R:F668	R:R:W664	6.01	Yes	Yes	3	9	8
181	R:R:I669	R:R:V665	7.68	No	No	0	7	7
182	R:R:L670	R:R:V666	4.47	Yes	No	1	9	9
183	R:R:F668	R:R:I667	5.02	Yes	No	3	9	8
184	R:R:I672	R:R:L676	4.28	No	No	0	8	7
185	R:R:N673	R:R:N677	6.81	No	Yes	1	9	9
186	R:R:N677	R:R:Y681	5.81	Yes	Yes	1	9	9
187	R:R:L680	R:R:Y681	8.21	No	Yes	0	9	9
188	R:R:P687	R:R:T685	10.49	No	No	0	5	9
189	R:R:F688	R:R:M691	6.22	Yes	Yes	0	8	5
190	R:R:F688	R:R:I692	5.02	Yes	No	0	8	5
191	R:R:F695	R:R:M691	4.98	No	Yes	4	1	5
192	R:R:L532	R:R:W536	3.42	No	No	0	7	9
193	R:R:G470	R:R:N401	3.39	No	No	0	7	7
194	R:R:A450	R:R:V498	3.39	No	Yes	0	8	8
195	R:R:I545	R:R:P546	3.39	No	Yes	0	5	9
196	R:R:I642	R:R:P643	3.39	No	No	0	7	9
197	R:R:I669	R:R:P643	3.39	No	No	0	7	9
198	R:R:L670	R:R:P671	3.28	Yes	No	0	9	9
199	R:R:C448	R:R:I427	3.27	No	No	0	8	8
200	R:R:C428	R:R:M429	3.24	No	Yes	0	4	6
201	R:R:S663	R:R:V562	3.23	No	No	0	8	8
202	R:R:F631	R:R:F635	3.22	No	No	0	7	5
203	R:R:V596	R:R:V634	3.21	No	No	0	5	9
204	R:R:F468	R:R:Y472	3.09	No	No	0	7	9
205	R:R:M454	R:R:S495	3.07	Yes	No	0	9	9
206	R:R:M602	R:R:S598	3.07	No	No	0	9	8
207	R:R:A576	R:R:E572	3.02	No	No	0	8	5
208	R:R:M454	R:R:T496	3.01	Yes	No	0	9	9
209	R:R:L458	R:R:S416	3	No	No	0	9	8
210	R:R:L447	R:R:S499	3	No	No	0	9	9
211	R:R:L494	R:R:V498	2.98	No	Yes	0	7	8
212	R:R:L566	R:R:V647	2.98	Yes	No	0	9	7
213	R:R:L650	R:R:V646	2.98	No	No	0	6	5
214	R:R:L501	R:R:T538	2.95	No	No	0	7	3
215	R:R:I537	R:R:I541	2.94	No	No	0	3	3
216	R:R:I541	R:R:I545	2.94	No	No	0	3	5
217	R:R:I529	R:R:M442	2.92	No	No	0	2	5
218	R:R:N560	R:R:T559	2.92	No	No	0	9	6
219	R:R:I529	R:R:K525	2.91	No	No	0	2	4
220	R:R:I657	R:R:L650	2.85	No	No	0	8	6
221	R:R:Q486	R:R:T483	2.83	Yes	No	0	6	1
222	R:R:G462	R:R:W413	2.81	No	Yes	0	8	9
223	R:R:A441	R:R:R430	2.77	No	Yes	0	7	9
224	R:R:A638	R:R:F592	2.77	No	No	0	8	8
225	R:R:A627	R:R:F603	2.77	No	No	0	8	7
226	R:R:A576	R:R:Y556	2.67	No	Yes	0	8	7
227	R:R:H607	R:R:M624	2.63	No	No	0	4	6
228	R:R:F645	R:R:V646	2.62	Yes	No	0	8	5
229	R:R:H693	R:R:K689	2.62	No	No	0	4	7
230	R:R:C449	R:R:W536	2.61	No	No	0	5	9
231	R:R:F630	R:R:M602	2.49	No	No	0	8	9
232	R:R:K689	R:R:R686	2.48	No	No	0	7	5
233	R:R:F645	R:R:L585	2.44	Yes	No	0	8	7
234	R:R:F688	R:R:L683	2.44	Yes	No	0	8	7
235	R:R:I512	R:R:Y516	2.42	No	Yes	0	5	7
236	R:R:N698	R:R:R694	2.41	No	No	0	6	5
237	R:R:I692	R:R:W696	2.35	No	No	0	5	4
238	R:R:F603	R:R:F630	2.14	No	No	0	7	8
239	R:R:G462	R:R:G463	2.11	No	No	0	8	5
240	R:R:C485	R:R:G558	1.96	No	No	0	9	7
241	R:R:G489	R:R:V488	1.84	No	No	0	9	6
242	R:R:G539	R:R:V498	1.84	No	Yes	0	7	8
243	R:R:G659	R:R:T662	1.82	No	No	0	5	7
244	R:R:G575	R:R:K554	1.74	No	No	0	6	5
245	R:R:C420	R:R:S416	1.72	No	No	0	5	8
246	R:R:G561	R:R:L402	1.71	No	Yes	0	7	9
247	R:R:G524	R:R:L439	1.71	No	No	0	6	7
248	R:R:A675	R:R:V418	1.7	No	No	0	9	5
249	R:R:A591	R:R:V500	1.7	No	No	0	8	8
250	R:R:C526	R:R:T530	1.69	No	No	0	5	2
251	R:R:A675	R:R:T419	1.68	No	No	0	9	8
252	R:R:A576	R:R:K554	1.61	No	No	0	8	5
253	R:R:V414	R:R:V418	1.6	No	No	0	6	5
254	R:R:E509	R:R:P523	1.57	No	No	0	9	6
255	R:R:A404	R:R:N401	1.56	No	No	0	7	7
256	R:R:K648	R:R:V581	1.52	No	No	0	8	7
257	R:R:F421	R:R:G422	1.51	No	No	0	4	8
258	R:R:L626	R:R:V606	1.49	No	No	0	7	7
259	R:R:L653	R:R:V655	1.49	No	No	0	4	5
260	R:R:I529	R:R:I533	1.47	No	No	0	2	3
261	R:R:I533	R:R:I537	1.47	No	No	0	3	3
262	R:R:L534	R:R:T538	1.47	No	No	0	1	3
263	R:R:I574	R:R:I578	1.47	No	No	0	4	2
264	R:R:L683	R:R:T684	1.47	No	No	0	7	8
265	R:R:P431	R:R:R430	1.44	No	Yes	0	5	9
266	R:R:P687	R:R:R686	1.44	No	No	0	5	5
267	R:R:I456	R:R:L453	1.43	No	No	0	6	7
268	R:R:I672	R:R:L639	1.43	No	No	0	8	5
269	R:R:I679	R:R:L683	1.43	No	No	0	7	7
270	R:R:P517	R:R:Y516	1.39	No	Yes	0	8	7
271	R:R:L487	R:R:L547	1.38	No	No	0	4	6
272	R:R:M480	R:R:Q477	1.36	No	No	0	8	5
273	R:R:E481	R:R:L478	1.33	No	No	0	6	3
274	R:R:F544	R:R:S548	1.32	No	No	0	4	4
275	R:R:E551	R:R:N549	1.31	No	No	0	3	4
276	R:R:L508	R:R:Y511	1.17	No	Yes	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L402	7.4875	4	2	9
2	R:R:Q408	7.75667	6	3	8
3	R:R:W413	4.9475	4	0	9
4	R:R:N423	6.475	4	0	9
5	R:R:M429	6	4	4	6
6	R:R:R430	7.41667	6	0	9
7	R:R:Y440	6.5225	4	0	7
8	R:R:M454	4.55	4	0	9
9	R:R:Y457	7.6175	4	0	9
10	R:R:W479	7.19167	6	2	9
11	R:R:Q486	4.785	4	1	6
12	R:R:V498	5.1175	4	0	8
13	R:R:Y511	7.288	5	5	5
14	R:R:V515	8.9075	4	5	7
15	R:R:Y516	5.9575	4	5	7
16	R:R:P546	11.666	5	1	9
17	R:R:F553	8.635	4	1	8
18	R:R:Y556	7.73714	7	1	7
19	R:R:Y557	8.226	5	1	9
20	R:R:F564	5.62	6	1	8
21	R:R:P565	6.525	4	1	8
22	R:R:L566	4.275	6	1	9
23	R:R:Y579	8.685	4	1	9
24	R:R:F584	4.975	4	1	8
25	R:R:N588	5.735	4	1	9
26	R:R:Y599	6.4125	4	0	9
27	R:R:W641	7.836	5	1	9
28	R:R:F645	4.3575	4	0	8
29	R:R:W664	9.55	4	3	8
30	R:R:F668	6.7325	4	3	9
31	R:R:L670	4.8875	4	1	9
32	R:R:N677	5.5375	4	1	9
33	R:R:Y681	5.8725	4	1	9
34	R:R:F688	5.0275	4	0	8
35	R:R:M691	5.568	5	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D465	R:R:L402	39.351	10.86	No	Yes	0	9	9
2	R:R:L402	R:R:Y472	13.4081	10.55	Yes	No	2	9	9
3	R:R:L402	R:R:W479	21.8399	6.83	Yes	Yes	2	9	9
4	R:R:D465	R:R:L403	41.4289	12.21	No	No	0	9	8
5	R:R:L403	R:R:Q408	43.4917	3.99	No	Yes	0	8	8
6	R:R:Q408	R:R:W664	52.6688	15.33	Yes	Yes	3	8	8
7	R:R:I661	R:R:W664	67.1008	3.52	No	Yes	0	6	8
8	R:R:I657	R:R:I661	70.8198	5.89	No	No	0	8	6
9	R:R:H567	R:R:I657	93.5256	3.98	No	No	0	8	8
10	R:R:H567	R:R:T662	96.7929	4.11	No	No	0	8	7
11	R:R:L566	R:R:T662	100	4.42	Yes	No	0	9	7
12	R:R:F564	R:R:L566	46.2998	4.87	Yes	Yes	1	8	9
13	R:R:F564	R:R:L670	25.5439	6.09	Yes	Yes	1	8	9
14	R:R:L670	R:R:P671	28.7811	3.28	Yes	No	0	9	9
15	R:R:L458	R:R:P671	24.0985	4.93	No	No	0	9	9
16	R:R:L458	R:R:S416	21.7345	3	No	No	0	9	8
17	R:R:F459	R:R:S416	16.9615	3.96	No	No	0	6	8
18	R:R:F459	R:R:W413	14.5524	5.01	No	Yes	0	6	9
19	R:R:F564	R:R:Y457	57.6828	4.13	Yes	Yes	0	8	9
20	R:R:M454	R:R:Y457	55.364	5.99	Yes	Yes	0	9	9
21	R:R:M454	R:R:S674	53.241	6.13	Yes	No	0	9	9
22	R:R:S674	R:R:T419	10.0806	4.8	No	No	0	9	8
23	R:R:D451	R:R:S674	51.8407	8.83	No	No	0	9	9
24	R:R:D451	R:R:N423	39.6221	6.73	No	Yes	0	9	9
25	R:R:C448	R:R:N423	32.3948	6.3	No	Yes	0	8	9
26	R:R:C448	R:R:V426	29.7598	6.83	No	No	0	8	9
27	R:R:T682	R:R:V426	28.8489	7.93	No	No	0	9	9
28	R:R:R430	R:R:T682	28.0208	6.47	Yes	No	0	9	9
29	R:R:I433	R:R:R430	45.5921	10.02	No	Yes	0	4	9
30	R:R:I433	R:R:M691	43.5143	5.83	No	Yes	0	4	5
31	R:R:F584	R:R:L566	48.1442	4.87	Yes	Yes	1	8	9
32	R:R:F584	R:R:N588	89.7312	4.83	Yes	Yes	1	8	9
33	R:R:N588	R:R:W641	83.7236	6.78	Yes	Yes	1	9	9
34	R:R:N673	R:R:W641	42.0387	10.17	No	Yes	1	9	9
35	R:R:N673	R:R:N677	46.1116	6.81	No	Yes	1	9	9
36	R:R:N677	R:R:Y681	50.7867	5.81	Yes	Yes	1	9	9
37	R:R:K510	R:R:Y681	47.7754	4.78	No	Yes	0	9	9
38	R:R:K510	R:R:Y440	50.463	11.94	No	Yes	0	9	7
39	R:R:I444	R:R:Y440	29.2554	3.63	No	Yes	0	9	7
40	R:R:I444	R:R:R430	27.3884	20.04	No	Yes	0	9	9
41	R:R:F688	R:R:M691	30.9945	6.22	Yes	Yes	0	8	5
42	R:R:F688	R:R:L683	22.5777	2.44	Yes	No	0	8	7
43	R:R:L683	R:R:T684	18.1209	1.47	No	No	0	7	8
44	R:R:R629	R:R:T684	15.8624	7.76	No	No	0	9	8
45	R:R:R629	R:R:T685	13.8598	3.88	No	No	0	9	9
46	R:R:P687	R:R:T685	11.5862	10.49	No	No	0	5	9
47	R:R:N437	R:R:Y440	15.6365	3.49	No	Yes	0	8	7
48	R:R:L439	R:R:N437	13.378	4.12	No	No	0	7	8
49	R:R:E497	R:R:N588	31.0924	3.94	No	Yes	0	9	9
50	R:R:E497	R:R:L501	27.6594	3.98	No	No	0	9	7
51	R:R:I535	R:R:L501	22.397	7.14	No	No	0	7	7
52	R:R:I535	R:R:L502	20.6053	4.28	No	No	0	7	7
53	R:R:L502	R:R:S446	18.806	10.51	No	No	0	7	8
54	R:R:L532	R:R:S446	16.9841	7.51	No	No	0	7	8
55	R:R:F468	R:R:Y472	11.5862	3.09	No	No	0	7	9
56	R:R:F564	R:R:P565	70.8274	4.33	Yes	Yes	1	8	8
57	R:R:P565	R:R:Y557	31.1827	4.17	Yes	Yes	1	8	9
58	R:R:L532	R:R:W536	15.1622	3.42	No	No	0	7	9
59	R:R:V498	R:R:W536	11.4658	12.26	Yes	No	0	8	9
60	R:R:D637	R:R:W641	37.7475	5.58	No	Yes	0	9	9
61	R:R:D637	R:R:I595	34.9921	4.2	No	No	0	9	8
62	R:R:I595	R:R:T507	33.3434	4.56	No	No	0	8	9
63	R:R:S598	R:R:T507	37.9056	4.8	No	No	0	8	9
64	R:R:T507	R:R:Y599	18.2865	4.99	No	Yes	0	9	9
65	R:R:S598	R:R:Y511	16.5249	5.09	No	Yes	0	8	5
66	R:R:M602	R:R:S598	21.4334	3.07	No	No	0	9	8
67	R:R:P565	R:R:Y556	36.829	12.52	Yes	Yes	1	8	7
68	R:R:K648	R:R:L566	15.9226	4.23	No	Yes	0	8	9
69	R:R:K648	R:R:S580	11.0668	4.59	No	No	0	8	9
70	R:R:P546	R:R:Y556	17.737	8.34	Yes	Yes	1	9	7
71	R:R:P546	R:R:Y557	14.9138	13.91	Yes	Yes	1	9	9
72	R:R:A576	R:R:Y556	14.2664	2.67	No	Yes	0	8	7
73	R:R:I657	R:R:L650	27.1851	2.85	No	No	0	8	6
74	R:R:L650	R:R:V646	18.3618	2.98	No	No	0	6	5
75	R:R:F645	R:R:V646	16.1183	2.62	Yes	No	0	8	5
76	R:R:F630	R:R:M602	18.0682	2.49	No	No	0	8	9
77	R:R:F603	R:R:F630	12.9263	2.14	No	No	0	7	8
78	R:R:C640	R:R:W641	11.8497	11.75	No	Yes	1	9	9
79	R:R:C640	R:R:I672	14.9289	4.91	No	No	0	9	8
80	R:R:I545	R:R:P546	28.4951	3.39	No	Yes	0	5	9
81	R:R:I541	R:R:I545	24.4147	2.94	No	No	0	3	5
82	R:R:I537	R:R:I541	20.3192	2.94	No	No	0	3	3
83	R:R:I533	R:R:I537	16.2087	1.47	No	No	0	3	3
84	R:R:I529	R:R:I533	12.0831	1.47	No	No	0	2	3
85	R:R:F668	R:R:W664	10.6452	6.01	Yes	Yes	3	9	8
86	R:R:D451	R:R:N677	21.8475	4.04	No	Yes	0	9	9
87	R:R:F564	R:R:F584	41.843	6.43	Yes	Yes	1	8	8
88	R:R:K510	R:R:Y599	14.7331	4.78	No	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7TMW_nogp

PDB Summary
PDB	7TMW_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.49
Number of Linked Nodes	256
Number of Links	276
Number of Hubs	35
Number of Links mediated by Hubs	128
Number of Communities	5
Number of Nodes involved in Communities	39
Number of Links involved in Communities	53

Path Summary
Number Of Nodes in MetaPath	89
Number Of Links MetaPath	88
Number of Shortest Paths	35996
Length Of Smallest Path	3
Average Path Length	13.8259
Length of Longest Path	36
Minimum Path Strength	1.45
Average Path Strength	5.85405
Maximum Path Strength	18.535
Minimum Path Correlation	0.7
Average Path Correlation	0.923184
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	44.1365
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.6531
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • hormone binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • connective tissue development • tube development • respiratory tube development • lung development • respiratory system development • lung connective tissue development • hormone-mediated signaling pathway • cellular component organization • extracellular matrix organization • cellular component organization or biogenesis • extracellular structure organization • external encapsulating structure organization • myofibroblast differentiation • cellular developmental process • cell differentiation • nipple development • mammary gland morphogenesis • mammary gland development • gland development • gland morphogenesis • animal organ morphogenesis • nipple morphogenesis • multi-multicellular organism process • reproductive process • parturition • multi-organism reproductive process • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9HBX9
Sequence	>7TMW_nogp_Chain_R E N L L A S I I Q R V F V W V V S A V T C F G N I F V I C M R P Y I E N K L Y A M S I I S L C C A D C L M G I Y L F V I G G F D L K F R G E Y N K H A Q L W M E S T H C Q L V G S L A I L S T E V S V L L L T F L T L E K Y I C I V Y P P G K C R T I T V L I L I W I T G F I V A F I P L S N K E F F K N Y Y G T N G V C F P L H E S I G A Q I Y S V A I F L G I N L A A F I I I V F S Y G S M F Y S V H Q E M I L A K R F F F I V F T D A L C W I P I F V V K F L S L L Q V E I P G T I T S W V V I F I L P I N S A L N P I L Y T L T T R P F K E M I H R F W Y N Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7TMW	A	Peptide	Relaxin	RXFP1	Homo sapiens	-	-	Gs/β1/γ2	3.2	2023-02-15	doi.org/10.1101/2022.01.22.477343
	7TMW (No Gprot)	A	Peptide	Relaxin	RXFP1	Homo sapiens	-	-		3.2	2023-02-15	doi.org/10.1101/2022.01.22.477343

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7TMW_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.